Indranil Sinha

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: EXPERIMENTAL HEMATOLOGY. 2025;:104712
A distinct alternative mRNA splicing profile identifies the oncogenic CD44 transcript variant 3 in KMT2A-rearranged pediatric T-cell acute lymphoblastic leukemia cells.
Ramilo Amor A; Enlund S; Sinha I; Jiang Q; Hermanson O; Nilsson A; Shirazi Fard S; Holm F
Article: EXPERIMENTAL CELL RESEARCH. 2024;437(2):114015
The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia
Enlund S; Sinha I; Neofytou C; Amor AR; Papadakis K; Nilsson A; Jiang Q; Hermanson O; Holm F
Article: NATURE COMMUNICATIONS. 2024;15(1):1752
Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
Kvedaraite E; Lourda M; Mouratidou N; Duking T; Padhi A; Moll K; Czarnewski P; Sinha I; Xagoraris I; Kokkinou E; Damdimopoulos A; Weigel W; Hartwig O; Santos TE; Soini T; Van Acker A; Rahkonen N; Tullberg MF; Ringqvist E; Buggert M; Jorns C; Lindforss U; Nordenvall C; Stamper CT; Unnersjoe-Jess D; Akber M; Nadisauskaite R; Jansson J; Vandamme N; Sorini C; Grundeken ME; Rolandsdotter H; Rassidakis G; Villablanca EJ; Idestroem M; Eulitz S; Arnell H; Mjoesberg J; Henter J-I; Svensson M
Article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae172
Genomic tumor evolution dictates human medulloblastoma progression.
Ruchiy Y; Tsea I; Preka E; Verhoeven BM; Olsen TK; Mei S; Sinha I; Blomgren K; Carlson L-M; Dyberg C; Johnsen JI; Baryawno N
Article: CHILDREN-BASEL. 2023;10(6):966
The Applicability of a 2-Transcript Signature to Identify Bacterial Infections in Children with Febrile Neutropenia
Aasa J; Tiselius E; Sinha I; Edman G; Wahlund M; Hedengren SS; Nilsson A; Berggren A
Article: EJHAEM. 2023;4(1):115-124
Malignant DFFB isoform switching promotes leukemia survival in relapse pediatric T-cell acute lymphoblastic leukemia
Enlund S; Sinha I; Amor AR; Fard SS; Tamm EP; Jiang Q; Lundin V; Nilsson A; Holm F
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023;11:1060537
Molecular and epigenetic alterations in normal and malignant myelopoiesis in human leukemia 60 (HL60) promyelocytic cell line model
Basu J; Madhulika S; Murmu KC; Mohanty S; Samal P; Das A; Mahapatra S; Saha S; Sinha I; Prasad P
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:930227
ERα and ERβ Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions
Song D; He H; Indukuri R; Huang Z; Stepanauskaite L; Sinha I; Haldosen L-A; Zhao C; Williams C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: ANTIOXIDANTS. 2021;10(7):1070
Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice
Dallner G; Bentinger M; Hussain S; Sinha I; Yang J; Schwank-Xu C; Zheng X; Swiezewska E; Brismar K; Valladolid-Acebes I; Tekle M
Article: CANCER LETTERS. 2021;506:23-34
Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor
Song D; He H; Sinha I; Hases L; Yan F; Archer A; Haldosen L-A; Zhao C; Williams C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity
Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(15):5305
The Feasibility of Host Transcriptome Profiling as a Diagnostic Tool for Microbial Etiology in Childhood Cancer Patients with Febrile Neutropenia
Wahlund M; Sinha I; Broliden K; Saghafian-Hedengren S; Nilsson A; Berggren A
Article: CELL REPORTS. 2020;31(5):107601
Srebf1 Controls Midbrain Dopaminergic Neurogenesis
Toledo EM; Yang S; Gyllborg D; van Wijk KE; Sinha I; Varas-Godoy M; Grigsby CL; Lonnerberg P; Islam S; Steffensen KR; Linnarsson S; Arenas E
Article: MOLECULAR METABOLISM. 2019;25:159-167
Epigenetic regulation of diabetogenic adipose morphology
Kerr AG; Sinha I; Dadvar S; Arner P; Dahlman I
Article: ONCOGENE. 2019;38(28):5725-5738
Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1
He H; Song D; Sinha I; Hessling B; Li X; Haldosen L-A; Zhao C
Article: ONCOGENE. 2018;37(19):2586-2600
c-Jun/AP-1 overexpression reprograms ERα signaling related to tamoxifen response in ERα-positive breast cancer
He H; Sinha I; Fan R; Haldosen L-A; Yan F; Zhao C; Dahlman-Wright K
Article: SCIENTIFIC REPORTS. 2017;7(1):10152
Epigenetic Regulation of PLIN1 in Obese Women and its Relation to Lipolysis
Bialesova L; Kulyte A; Petrus P; Sinha I; Laurencikiene J; Zhao C; Wright KD; Arner P; Dahlman I
Article: DIABETOLOGIA. 2016;59(11):2393-2405
The epigenetic signature of systemic insulin resistance in obese women
Arner P; Sahlqvist A-S; Sinha I; Xu H; Yao X; Waterworth D; Rajpal D; Loomis AK; Freudenberg JM; Johnson T; Thorell A; Naslund E; Ryden M; Dahlman I
Article: CANCER RESEARCH. 2016;76(19):5634-5646
Estrogen Receptor a Promotes Breast Cancer by Reprogramming Choline Metabolism
Jia M; Andreassen T; Jensen L; Bathen TF; Sinha I; Gao H; Zhao C; Haldosen L-A; Cao Y; Girnita L; Moestue SA; Dahlman-Wright K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184
Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes
Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
Article: ONCOGENE. 2016;35(15):1955-1964
RING finger protein 31 promotes p53 degradation in breast cancer cells
Zhu J; Zhao C; Zhuang T; Jonsson P; Sinha I; Williams C; Stromblad S; Dahlman-Wright K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(10):5068-5079
AP-1 Is a Key Regulator of Proinflammatory Cytokine TNF α-mediated Triple-negative Breast Cancer Progression
Qiao Y; He H; Jonsson P; Sinha I; Zhao C; Dahlman-Wright K
Article: MOLECULAR METABOLISM. 2016;5(3):171-183
Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
Kirchner H; Sinha I; Gao H; Ruby MA; Schonke M; Lindvall JM; Barres R; Krook A; Naslund E; Dahlman-Wright K; Zierath JR
Article: SCIENTIFIC REPORTS. 2016;6:18617
Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone
Wang Y; Fisahn A; Sinha I; Nguyen DP; Sterzenbach U; Lallemend F; Hadjab S
Article: OBESITY. 2016;24(1):250-261
Differential methylation in inflammation and type 2 diabetes genes in siblings born before and after maternal bariatric surgery
Berglind D; Muller P; Willmer M; Sinha I; Tynelius P; Naslund E; Dahlman-Wright K; Rasmussen F
Article: MOLECULAR METABOLISM. 2015;4(12):891-902
Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(6):910-919
The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Dahlman I; Sinha I; Gao H; Brodin D; Thorell A; Ryden M; Andersson DP; Henriksson J; Perfilyev A; Ling C; Dahlman-Wright K; Arner P
Article: GENOME RESEARCH. 2015;25(6):872-883
A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin
Svensson JP; Shukla M; Menendez-Benito V; Norman-Axelsson U; Audergon P; Sinha I; Tanny JC; Allshire RC; Ekwall K
Article: CLINICAL EPIGENETICS. 2015;7(1):93
The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Arner P; Sinha I; Thorell A; Ryden M; Dahlman-Wright K; Dahlman I
Article: CANCER RESEARCH. 2014;74(14):3983-3994
Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
Article: PLOS ONE. 2013;8(8):e72409
Erg Channel Is Critical in Controlling Cell Volume during Cell Cycle in Embryonic Stem Cells
Abdelhady S; Kitambi SS; Lundin V; Aufschnaiter R; Sekyrova P; Sinha I; Lundgren KT; Castelo-Branco G; Linnarsson S; Wedlich-Soeldner R; Teixeira A; Andang M
Article: EMBO JOURNAL. 2012;31(18):3718-3729
Positional differences of axon growth rates between sensory neurons encoded by runx3
Lallemend F; Sterzenbach U; Hadjab-Lallemend S; Aquino JB; Castelo-Branco G; Sinha I; Villaescusa JC; Levanon D; Wang Y; Franck MCM; Kharchenko O; Adameyko I; Linnarsson S; Groner Y; Turner E; Ernfors P
Article: EPIGENOMICS. 2010;2(3):377-393
Genome-wide mapping of histone modifications and mass spectrometry reveal H4 acetylation bias and H3K36 methylation at gene promoters in fission yeast
Sinha I; Buchanan L; Roennerblad M; Bonilla C; Durand-Dubief M; Shevchenko A; Grunstein M; Stewart AF; Ekwall K
Article: EMBO JOURNAL. 2007;26(10):2477-2488
Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing
Durand-Dubief M; Sinha I; Fagerstroem-Billai F; Bonilla C; Wright A; Grunstein M; Ekwall K
Article: MOLECULAR CELL. 2006;22(2):169-178
Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions
Zhu XF; Wirén M; Sinha I; Rasmussen NN; Linder T; Holmberg S; Ekwall K; Gustafsson CM
Article: CHROMOSOME RESEARCH. 2006;14(1):95-105
Genome-wide patterns of histone modifications in fission yeast
Sinha I; Wirén M; Ekwall K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;334(4):1149-1158
Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro
Singh V; Sinha I; Sadhale PP
Article: EMBO JOURNAL. 2005;24(16):2906-2918
Genome wide analysis of nucleosome density histone acetylation and HDAC function in fission yeast
Wirén M; Silverstein RA; Sinha I; Walfridsson J; Lee HM; Laurenson P; Pillus L; Robyr D; Grunstein M; Ekwall K
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Preprint: BIORXIV. 2024
A Distinct Alternative mRNA Splicing Profile Identifies the Oncogenic CD44 Transcript Variant 3 in KMT2A-Rearranged Pediatric T-cell Acute Lymphoblastic Leukemia Cells
Amor AR; Enlund S; Sinha I; Jiang Q; Hermanson O; Nilsson A; Shirazi Fard S; Holm F
Conference publication: NEURO-ONCOLOGY. 2023;25:i62
SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA
Ruchiy Y; Tsea I; Verhoeven BM; Sinha I; Preka E; Olsen TK; Mei S; Blomgren K; Johnsen JI; Carlson L-M; Dyberg C; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)
Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling
Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Conference publication: CANCER RESEARCH. 2020;80(16):4085
Blocking Fra-1 sensitises triple-negative breast cancer to olaparib
Song D; He H; Sinha I; Pettersson L; Yan F; Haldosen L-A; Zhao C; Williams C
Published conference paper: BRITISH JOURNAL OF SURGERY. 2019;106(5):563-573
Autologous fat transplantation alters gene expression patterns related to inflammation and hypoxia in the irradiated human breast
Lindegren A; Schultz I; Sinha I; Cheung L; Khan AA; Tekle M; Wickman M; Halle M
Corrigendum: DIABETOLOGIA. 2016;59(12):2728
The epigenetic signature of systemic insulin resistance in obese women (vol 59, pg 2393, 2016)
Arner P; Sahlqvist A-S; Sinha I; Xu H; Yao X; Waterworth D; Rajpal D; Loomis AK; Freudenberg JM; Johnson T; Thorell A; Naslund E; Ryden M; Dahlman I
Doctoral thesis: 2010
Genome-wide patterns of histone modifications in fission yeast
Sinha I

Anställningar

Forskningsspecialist, Laboratoriemedicin, Karolinska Institutet, 2025-
Bioinformatiker, Kvinnors och barns hälsa, Karolinska Institutet, 2020-2024

Examina och utbildning

Filosofie Doktorsexamen, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2010

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