Helge Gad

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: CANCER RESEARCH. 2023;83(7_Supplement):1569
Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1
Berglund UW; Gad H; Sanjiv K; Jemth A-S; Mortusewics O; Brautigam L; Rantala J; Helleday T
Article: CANCER RESEARCH. 2021;81(22):5733-5744
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv K; Calderon-Montano JM; Pham TM; Erkers T; Tsuber V; Almlof I; Hoglund A; Heshmati Y; Seashore-Ludlow B; Danda AN; Gad H; Wiita E; Gokturk C; Rasti A; Friedrich S; Centio A; Estruch M; Vatsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Monch K; Garnett MJ; Ostling P; Walfridsson J; Helleday T; Berglund UW
Article: CANCER RESEARCH. 2021;81(15):4079-4093
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
Zhao Z; Gad H; Benitez-Buelga C; Sanjiv K; Hua X; Kang H; Feng M; Zhao Z; Berglund UW; Xia Q; Helleday T
Article: SCIENTIFIC REPORTS. 2021;11(1):6317
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Oksvold MP; Berglund UW; Gad H; Bai B; Stokke T; Rein ID; Pham T; Sanjiv K; Oy GF; Norum JH; Smeland EB; Myklebust JH; Helleday T; Vatsveen TK
Article: SCIENTIFIC REPORTS. 2021;11(1):3490
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Miguel Baquero J; Benitez-Buelga C; Rajagopal V; Zhao Z; Torres-Ruiz R; Mueller S; Hanna BMF; Loseva O; Wallner O; Michel M; Rodriguez-Perales S; Gad H; Visnes T; Helleday T; Benitez J; Osorio A
Article: NUCLEIC ACIDS RESEARCH (NAR). 2020;48(21):12234-12251
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Visnes T; Benitez-Buelga C; Cazares-Korner A; Sanjiv K; Hanna BMF; Mortusewicz O; Rajagopal V; Albers JJ; Hagey DW; Bekkhus T; Eshtad S; Baquero JM; Masuyer G; Wallner O; Muller S; Pham T; Gokturk C; Rasti A; Suman S; Torres-Ruiz R; Sarno A; Wiita E; Homan EJ; Karsten S; Marimuthu K; Michel M; Koolmeister T; Scobie M; Loseva O; Almlof I; Unterlass JE; Pettke A; Bostrom J; Pandey M; Gad H; Herr P; Jemth A-S; El Andaloussi S; Kalderen C; Rodriguez-Perales S; Benitez J; Krokan HE; Altun M; Stenmark P; Berglund UW; Helleday T
Article: CANCER RESEARCH. 2020;80(17):3530-3541
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
Article: CELL DEATH AND DIFFERENTIATION. 2020;27(7):2081-2098
AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma
Das I; Gad H; Braeutigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Rajagopal V; Hansson J; Helleday T; Brage SE; Berglund UW
Journal article: CANCER RESEARCH. 2019;79(13_Supplement):105
Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Sanjiv K; gad H; Rudd SG; Mortusewicz O; Stolz A; Amaral N; Brautigham L; Pudelko L; Kaldéren C; Jemth A-S; Almlöf I; Visnes T; Schultz N; Boström J; Montano1 JMC; Hagenkort A; Groth P; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Altun M; Ström C; Scobie M; Bastians H; Berglund UW; Helleday T
Article: THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY. 2019;11:1758835919866960
Karonudib is a promising anticancer therapy in hepatocellular carcinoma
Hua X; Sanjiv K; Gad H; Pham T; Gokturk C; Rasti A; Zhao Z; He K; Feng M; Zang Y; Zhang J; Xia Q; Helleday T; Berglund UW
Article: ONCOTARGET. 2017;8(49):84671-84684
Glioblastoma and glioblastoma stem cells are dependent on functional MTH1
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderen C; Hoglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hagerstrand D; Berglund UW; Helleday T; Brautigam L
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: CELL DEATH AND DISEASE. 2016;7(6):e2267
Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks
Rassoolzadeh H; Bohm S; Hedstrom E; Gad H; Helleday T; Henriksson S; Farnebo M
Article: CANCER RESEARCH. 2016;76(8):2366-2375
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Brautigam L; Pudelko L; Jemth A-S; Gad H; Narwal M; Gustafsson R; Karsten S; Puigvert JC; Homan E; Berndt C; Berglund UW; Stenmark P; Helleday T
Article: NATURE COMMUNICATIONS. 2015;6:7871
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter M; Jemth A-S; Hagenkort A; Page BDG; Gustafsson R; Griese JJ; Gad H; Valerie NCK; Desroses M; Bostrom J; Berglund UW; Helleday T; Stenmark P
Journal article: EUROPEAN JOURNAL OF CANCER. 2014;50:s203
835: Inhibiting MTH1 kills cancer cells by preventing sanitisation of oxidised dNTP pool
Berglund UW; Gad H; Jemth AS; Koolmeister T; Gokturk C; Pham T; Nilsson J; Eshtad S; Scobie M; Helleday T
Article: NATURE. 2014;508(7495):215-221
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Article: NATURE CELL BIOLOGY. 2011;13(5):559-567
ARFGAP1 promotes AP-2-dependent endocytosis.
Bai M; Gad H; Turacchio G; Cocucci E; Yang J-S; Li J; Beznoussenko GV; Nie Z; Luo R; Fu L; Collawn JF; Kirchhausen T; Luini A; Hsu VW
Article: NATURE CELL BIOLOGY. 2008;10(10):1146-1153
A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance.
Yang J-S; Gad H; Lee SY; Mironov A; Zhang L; Beznoussenko GV; Valente C; Turacchio G; Bonsra AN; Du G; Baldanzi G; Graziani A; Bourgoin S; Frohman MA; Luini A; Hsu VW
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(17):6445-6450
Role of epsin 1 in synaptic vesicle endocytosis
Jakobsson J; Gad H; Andersson F; Low P; Shupliakov O; Brodin L
Article: JOURNAL OF NEUROSCIENCE. 2007;27(2):379-390
Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse
Evergren E; Gad H; Walther K; Sundborger A; Tomilin N; Shupliakov O
Article: NATURE CELL BIOLOGY. 2006;8(12):1376-1382
Key components of the fission machinery are interchangeable.
Yang J-S; Zhang L; Lee SY; Gad H; Luini A; Hsu VW
Article: EMBO JOURNAL. 2005;24(23):4133-4143
A role for BARS at the fission step of COPI vesicle formation from Golgi membrane.
Yang J-S; Lee SY; Spanò S; Gad H; Zhang L; Nie Z; Bonazzi M; Corda D; Luini A; Hsu VW
Article: TRAFFIC. 2004;5(7):514-528
Amphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapse
Evergren E; Marcucci M; Tomilin N; Löw P; Slepnev V; Andersson F; Gad H; Brodin L; De Camilli P; Shupliakov O
Article: JOURNAL OF NEUROSCIENCE METHODS. 2004;135(1-2):169-174
A pre-embedding immunogold approach for detection of synaptic endocytic proteins in situ
Evergren E; Tomilin N; Vasylieva E; Sergeeva V; Bloom O; Gad H; Capani F; Shupliakov O
Article: NEURON. 2000;27(2):301-312
Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin
Gad H; Ringstad N; Löw P; Kjaerulff O; Gustafsson J; Wenk M; Di Paolo G; Nemoto Y; Crum J; Ellisman MH; De Camilli P; Shupliakov O; Brodin L
Article: NEURON. 1999;24(1):143-154
Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis
Ringstad N; Gad H; Löw P; Di Paolo G; Brodin L; Shupliakov O; De Camilli P
Article: NEURON. 1998;21(3):607-616
Dissociation between Ca²⁺-triggered synaptic vesicle exocytosis and clathrin-mediated endocytosis at a central synapse
Gad H; Low P; Zotova E; Brodin L; Shupliakov O
Article: SCIENCE. 1997;276(5310):259-263
Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions
Shupliakov O; Low P; Grabs D; Gad H; Chen H; David C; Takei K; DeCamilli P; Brodin L
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Meeting abstract: CANCER RESEARCH. 2023;83(7):6204
DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101
Danda AN; Gad H; Scobie M; Martinez-Lopez L; Carrillo NP; Orta ML; Helleday T; Berglund UW; Sanjiv K
Conference publication: 2021;:9227
NEIL3-mediated mitotic base excision repair of oxidative lesions at telomeres prevents senescence in hepatocellular carcinoma
Gad H; Zhenjun Z; Benitez-Buelga C; Sanjiv K; Xiangwei H; Kang H; Mingxuan F; Zhicong Z; Warpman Berglund U; Qiang X; Helleday T
Meeting abstract: BLOOD. 2020;136:18-19
Karonudib Has Potent Anti-Tumor Effects in Preclinical Models of B-Cell Lymphoma
Oksvold MP; Berglund UW; Gad H; Bai B; Stokke T; Rein ID; Pham T; Sanjiv K; Oy GF; Norum JH; Smeland EB; Myklebust JH; Helleday T; Vatsveen TK
Preprint: RESEARCH SQUARE. 2020
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates Methotrexate anticancer effects
Baquero JM; Benítez-Buelga C; Rajagopal V; Zhenjun Z; Torres-Ruiz R; Mueller S; Hanna BMF; Loseva O; Wallner O; Michel M; Rodríguez-Perales S; Gad H; Visnes T; Helleday T; Benítez J; Osorio A
Preprint: RESEARCH SQUARE. 2020
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates Methotrexate anticancer effects
Baquero JM; Benítez-Buelga C; Rajagopal V; Zhenjun Z; Torres-Ruiz R; Mueller S; Hanna BMF; Loseva O; Wallner O; Michel M; Rodríguez-Perales S; Gad H; Visnes T; Helleday T; Benítez J; Osorio A
Corrigendum: ONCOTARGET. 2020;11(8):827
Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.
Pudelko L; Rouhi P; Sanjiv K; Gad H; Kalderén C; Höglund A; Squatrito M; Schuhmacher AJ; Edwards S; Hägerstrand D; Berglund UW; Helleday T; Bräutigam L
Meeting abstract: ANNALS OF ONCOLOGY. 2019;30:vii8
Therapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma
Das I; Gad H; Brautigam L; Pudelko L; Tuominen R; Hoiom V; Almlof I; Hansson J; Helleday T; Brage SE; Berglund UW
Meeting abstract: CANCER RESEARCH. 2019;79(13):105
MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Sanjiv K; Gad H; Rudd SG; Mortusewicz O; Stolz A; Amaral N; Brautigham L; Pudelko L; Kalderen C; Jemth A-S; Almlof I; Visnes T; Schultz N; Bostrom J; Montano JMC; Hagenkort A; Groth P; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Altun M; Strom C; Scobie M; Bastians H; Berglund UW; Helleday T
Preprint: BIORXIV. 2019
MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Gad H; Mortusewicz O; Rudd S; Stolz A; Amaral N; Brautigham L; Pudelko L; Sanjiv K; Kaldéren C; Jemth A-S; Almlöf I; Visnes T; Schultz N; Boström J; Calderon Montano JM; Hagenkort A; Groth P; Loseva O; Gokturk C; Koolmeister T; Wakchaure P; Homan E; Ström C; Scobie M; Bastians H; Berglund UW; Helleday T
Preprint: BIORXIV. 2019
MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression
Rudd S; Gad H; Amaral N; Hagenkort A; Groth P; Ström C; Mortusewicz O; Berglund UW; Helleday T
Meeting abstract: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(5):S200
Effects of MTH1 inhibitor TH1579 on cutaneous melanoma
Das I; Gad H; Pudelko L; Brautigam L; Tuominen R; Helleday T; Hansson J; Brage S; Berglund U
Corrigendum: NATURE. 2017;544(7651):508
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014)
Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Strom CE; Svensson LM; Schultz N; Lundback T; Einarsdottir BO; Saleh A; Gokturk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Stromberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Brautigam L; Johansson L; Hoglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarstrom LGJ; Wiita E; Almlof I; Kalderen C; Axelsson H; Djureinovic T; Puigvert JC; Haggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T
Meeting abstract: CANCER RESEARCH. 2016;76:1260
Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell
Sanjiv K; Gad H; Rudd S; Hurley R; Herr P; Montano JMC; Mortusewicz O; Koolmeister T; Jaques S; Moron EB; Hoglund A; Lee T-C; Scobie M; Kaufmann S; Weroha J; Berglund UW; Hendrickson AW; Helleday T
Conference publication: EUROPEAN JOURNAL OF CANCER. 2014;50:S203
Inhibiting MTH1 kills cancer cells by preventing sanitisation of oxidised dNTP pool
Berglund UW; Gad H; Jemth AS; Koolmeister T; Gokturk C; Pham T; Nilsson J; Eshtad S; Scobie M; Helleday T
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2004;15:79A-80A
Localization of SH3 domain-containing proteins in the dynamin fission complex formed in situ
Sundborger A; Gad H; Tomilin N; Evergren E; Andersson F; Löw P; Brodin L; Shupliakov O
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2004;15:77A-78A
A role of intersectin in synaptic vesicle recycling in a vertebrated synapse
Evergren E; Gad H; Sundborger A; Walther K; Shupliakov O
Thesis / dissertation: 2000
Synaptic vesicle endocytosis studied in a living synapse
Gad, Helge
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2000;11:218A
Dynamin plays a role in early stages of clathrin-mediated synaptic vesicle endocytosis
Gad H; Bloom O; Löw P; De Camilli P; Slepnev V; Shupliakov O; Brodin L
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1999;10:308A
Critical role of the interaction between endophilin and synaptojanin at late stages in clathrin-mediated synaptic vesicle endocytosis
Gad H; Shupliakov O; Löw P; Ringstad N; Di Paulo G; Kjaerulff O; Wenk M; Nemoto Y; DeCamili P; Brodin L
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1999;10:308A
Endophilin/SH3p4 is required for early stages in clathrin-mediated endocytosis
Ringstad N; Gad H; Löw P; Brodin L; Di Paulo G; Shupliakov O; De Camilli P
Review: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(12):2503-2511
Sustained neurotransmitter release:: New molecular clues
Brodin L; Löw P; Gad H; Gustafsson J; Pieribone VA; Shupliakov O
Published conference paper: ACTA PHYSIOLOGICA. 1996;157(3):369-379
Presynaptic mechanisms in central synaptic transmission: 'Biochemistry' of an intact glutamatergic synapse
Shupliakov O; Pieribone VA; Gad H; Brodin L
Other: EUROPEAN JOURNAL OF NEUROSCIENCE. 1995;7(5):1111-1116
SYNAPTIC VESICLE DEPLETION IN RETICULOSPINAL AXONS IS REDUCED BY 5-HYDROXYTRYPTAMINE - DIRECT EVIDENCE FOR PRESYNAPTIC MODULATION OF GLUTAMATERGIC TRANSMISSION
SHUPLIAKOV O; PIERIBONE VA; GAD H; BRODIN L
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Senior Forskare, Onkologi-Patologi, Karolinska Institutet, 2022-

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Institutionen för neurovetenskap, Karolinska Institutet, 2000

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