Helena Harris

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Helena Erlandsson Harris är professor i reumatologisk inflammationsforskning och forskar om de kemiska signaler i kroppen som sätter i gång och förstärker en inflammation. Framför allt intresserar hon sig för proteinet HMGB1, ett ämne som kroppen använder som kemisk larmsignal. Målet är att bidra till utvecklingen av nya läkemedel som hjälper människor med kronisk eller akut inflammation till ett bättre liv.

Artiklar

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2025;301(12):110866
Mapping the intracellular HMGB1 interactome and alterations induced by Toll-like receptor 4 activation
Heinback R; van der Zijde M; Tsang CH; Trselic T; Espinosa A; Aulin C; Harris HE
Article: PEDIATRIC RHEUMATOLOGY. 2025;23(1):129
Presence and reactivities of antibodies directed to citrullinated peptides in a Swedish JIA cohort
Saleh R; Sundberg E; Hansson M; Mathsson-Alm L; Skriner K; Serre G; Lundberg K; Padyukov L; Harris HE
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2025;102(4):e70055
Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma
Qu H; Neog M; Palmblad K; Sundberg E; Lovquist A; Melen E; Aulin C; Harris HE
Article: FRONTIERS IN IMMUNOLOGY. 2025;16:1599747
Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular juvenile idiopathic arthritis
Wen X; Aulin C; Sundberg E; Qu H; Struglics A; Merritt A-S; Melen E; Altman M; Harris HE
Article: OSTEOARTHRITIS AND CARTILAGE OPEN. 2025;7(1):100543
Proteomic analysis reveals biomarkers associated with performance-based joint function and patient-reported outcomes in knee osteoarthritis
Naili JE; Ahmed AS; Hedstrom M; Simonsen MB; Brostrom EW; Harris HE; Vegvari A; Aulin C
Article: PEDIATRIC RHEUMATOLOGY. 2024;22(1):79
Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study
Saleh R; Sundberg E; Olsson M; Tengvall K; Alfredsson L; Kockum I; Padyukov L; Harris HE
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(1):e2350658
The cellular microenvironment regulates CX3CR1 expression on CD8⁺ T cells and the maintenance of CX3CR1⁺ CD8⁺ T cells
Pokharel J; Shryki I; Zwijnenburg AJ; Sandu I; Krumm L; Bekiari C; Avramov V; Heinback R; Lysell J; Eidsmo L; Harris HE; Gerlach C
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(3):394-411
Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery.
Zhao ZB; Marschner JA; Iwakura T; Li C; Motrapu M; Kuang M; Popper B; Linkermann A; Klocke J; Enghard P; Muto Y; Humphreys BD; Harris HE; Romagnani P; Anders H-J
Article: OSTEOARTHRITIS AND CARTILAGE. 2022;30(9):1198-1209
The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury
Aulin C; Larsson S; Vogl T; Roth J; Akesson A; Sward P; Heinback R; Harris HE; Struglics A
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:911744
The Neuroimmune Response to Surgery - An Exploratory Study of Trauma-Induced Changes in Innate Immunity and Heart Rate Variability
Hildenborg M; Kahlin J; Granath F; Schening A; Granstrom A; Ebberyd A; Klevenvall L; Zetterberg H; Han J; Schlegel TT; Harris R; Harris HE; Eriksson LI
Article: BIOMOLECULES. 2022;12(6):779
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
Qu H; Heinback R; Salo H; Ewing E; Espinosa A; Aulin C; Erlandsson Harris H
Article: PEDIATRIC RHEUMATOLOGY. 2021;19(1):173
Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study.
Qu H; Sundberg E; Aulin C; Neog M; Palmblad K; Horne AC; Granath F; Ek A; Melén E; Olsson M; Harris HE
Article: MOLECULAR MEDICINE. 2021;27(1):58
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ
Article: BIOMOLECULES. 2021;11(6):800
Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns
Salo H; Qu H; Mitsiou D; Aucott H; Han J; Zhang X; Aulin C; Erlandsson Harris H
Article: MOLECULAR MEDICINE. 2021;27(1):48
Therapeutic administration of etoposide coincides with reduced systemic HMGB1 levels in macrophage activation syndrome.
Palmblad K; Schierbeck H; Sundberg E; Horne A-C; Erlandsson Harris H; Henter J-I; Andersson U
Article: BRITISH JOURNAL OF ANAESTHESIA. 2021;126(2):467-476
Association between cerebrospinal fluid biomarkers of neuronal injury or amyloidosis and cognitive decline after major surgery
Danielson M; Wiklund A; Granath F; Blennow K; Mkrtchian S; Nellgard B; Oras J; Fagerlund MJ; Granstrom A; Schening A; Rasmussen LS; Harris HE; Zetterberg H; Ricksten S-E; Eriksson LI
Article: PAIN. 2021;162(2):459-470
Sex- and cell-dependent contribution of peripheral high mobility group box 1 and TLR4 in arthritis-induced pain
Rudjito R; Agalave NM; Farinotti AB; Lundback P; Szabo-Pardi TA; Price TJ; Harris HE; Burton MD; Svensson CI
Article: PAIN. 2021;162(2):446-458
Sex-dependent role of microglia in disulfide high mobility group box 1 protein-mediated mechanical hypersensitivity
Agalave NM; Rudjito R; Farinotti AB; Khoonsari PE; Sandor K; Nomura Y; Szabo-Pardi TA; Urbina CM; Palada V; Price TJ; Harris HE; Burton MD; Kultima K; Svensson CI
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:448262
Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
Sowinska A; Rensing M; Klevenvall L; Neog M; Lundback P; Harris HE
Article: EXPERIMENTAL PHYSIOLOGY. 2020;105(9):1634-1647
The impact of damage-associated molecular patterns on the neurotransmitter release and gene expression in theex vivorat carotid body
Mkrtchian S; Kahlin J; Gomez-Galan M; Ebberyd A; Yoshitake T; Schmidt S; Kehr J; Hildenborg M; Fagerlund MJ; Harris HE; Eriksson LI
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Alla övriga publikationer

Conference publication: OSTEOARTHRITIS AND CARTILAGE. 2023;31:S26
ANTI-INFLAMMATORY POLYMERS AS POTENTIAL THERAPEUTICS IN KNEE OSTEOARTHRITIS
Aulin C; Melander-Bowden T; Erlandsson-Harris H; Engstrand T
Conference publication: OSTEOARTHRITIS AND CARTILAGE. 2022;30:S171-S172
INCREASED LEVELS OF HMGB1 AND S100A8/A9 IN SYNOVIAL FLUID AFTER KNEE INJURY MAY CONTRIBUTE TO OA PROGRESSION AND DISPLAY POTENTIAL THERAPEUTIC POSSIBILITIES
Aulin C; Larsson S; Vogl T; Roth J; Akesson A; Sward P; Heinback R; Erlandsson-Harris H; Struglics A
Other: MOLECULAR MEDICINE. 2020;26(1):131
High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome (Retraction of Vol 20, Pg 538, 2014)
Palmblad K; Schierbeck H; Sundberg E; Horne A-C; Harris HE; Henter J-I; Antoine DJ; Andersson U
Other: MOLECULAR MEDICINE. 2020;26(1):133
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) (Retraction of Vol 18, Pg 250, 2012)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Other: MOLECULAR MEDICINE. 2020;26(1):18
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) (Expression of Concern of Vol 18, Pg 250, 2012)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Other: MOLECULAR MEDICINE. 2020;26(1):17
High systematic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome (Expression of Concern of Vol 20, Pg 538, 2014)
Palmblad K; Schierbeck H; Sundberg E; Horne A-C; Harris HE; Henter J-I; Antoine DJ; Andersson U
Review: SEMINARS IN IMMUNOLOGY. 2018;38(C):40-48
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells
Andersson U; Yang H; Harris H
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2018;22(3):263-277
Extracellular HMGB1 as a therapeutic target in inflammatory diseases
Andersson U; Yang H; Harris H
Conference publication: OSTEOARTHRITIS AND CARTILAGE. 2016;24:S161
INTRAARTICULAR DRUG DELIVERY OF ANTI-HMGB1 IN HYALURONAN GELS FOR CARTILAGE REPAIR
Aulin C; Erlandsson-Harris H; Palmblad K; Klareskog L
Corrigendum: EMBO JOURNAL. 2013;32(1):172
TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis (vol 32, pg 86, 2013)
Nystrom S; Antoine DJ; Lundback P; Lock JG; Nita AF; Hogstrand K; Grandien A; Erlandsson-Harris H; Andersson U; Applequist SE
Conference publication: JOURNAL OF IMMUNOLOGY. 2012;188:114.7
PKR is required for NLRP3 inflammasome activation and HMGB1 release
Lu B; Nakamura T; Inouye K; Valdes-Ferrer S; Olofsson P; Li J; Wang H; Erlandsson-Harris H; Kalb T; Andersson U; Yang H; Chavan S; Hotamisligil G; Tracey K
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a81-a82
THE PRO-INFLAMMATORY EFFECT OF HMGB1, A MEDIATOR OF INFLAMMATION IN ARTHRITIS, IS DEPENDENT ON THE REDOX STATUS OF THE PROTEIN
Ottosson L; Lundback P; Hreggvidsdottir H; Yang H; Tracey KJ; Antoine DJ; Erlandsson-Harris H; Andersson U
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a43-a44
CROSSTALK BETWEEN NITROSATIVE STRESS AND ALTERED CA2⁺ HANDLING IN ARTHRITIS-INDUCED SKELETAL MUSCLE DYSFUNCTION
Bruton J; Yamada T; Ivarsson N; Grundtman C; Zhang S-J; Erlandsson-Harris H; Lundberg IE; Lanner JT; Cheng AJ; Westerblad H
Review: NATURE REVIEWS RHEUMATOLOGY. 2012;8(4):195-202
HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
Harris HE; Andersson U; Pisetsky DS
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a77-a78
SUCCESSFUL THERAPY WITH ANTI-HMGB1 MONOCLONAL ANTIBODIES IN TWO SEPARATE EXPERIMENTAL ARTHRITIS MODELS
Schierbeck H; Lundback P; Palmblad K; Klevenvall L; Li JH; Chavan S; Yang H; Harris HE; Andersson U; Ottosson L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:A38
INTERLEUKIN 1β AND TLR LIGANDS GIVE ENHANCED CYTOKINE PRODUCTION BY THEIR INTERACTION WITH HMGB1
Hreggvidsdottir HS; Wahamaa H; Ostberg T; Schierbeck H; Aveberger A; Klevenvall L; Andersson U; Harris HE
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:a36-a37
IMMUNOMODULATORY DRUGS CAN INHIBIT THE EXTRACELLULAR RELEASE OF HMGB1 FROM CULTURED HUMAN MONOCYTES
Schierbeck H; Wahamaa H; Ostberg T; Andersson U; Harris HE
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1799(1-2):141-148
The role of HMGB1 in the pathogenesis of rheumatic disease
Andersson U; Harris HE
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2008;67:A20
High mobility group box chromosomal protein-1 (HMGB-1) is expressed in idiopathic inflammatory myopathies and mediates muscle weakness
Grundtman C; Bruton J; Oestberg T; Erlandsson-Harris H; Andersson U; Westerblad H; Lundberg IE
Review: ARTHRITIS RESEARCH & THERAPY. 2008;10(3):209
High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
Pisetsky DS; Erlandsson-Harris H; Andersson U
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Anställningar

Professor, Reumatologisk inflammationsforskning, Medicin, Solna, Karolinska Institutet, 2014-

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