Helena Erlandsson Harris

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About me

Helena Erlandsson Harris is a Professor of Rheumatological Inflammation Research and is conducting research into the chemical signals in the body that initiate and increase an inflammation. Above all she is interested in the protein HMGB1, a substance which the body uses as a chemical alarm signal. The goal is to contribute to the development of new drugs that can help people with chronic or acute inflammation and give them better life quality.

Articles

Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(1):e2350658
The cellular microenvironment regulates CX3CR1 expression on CD8⁺ T cells and the maintenance of CX3CR1⁺ CD8⁺ T cells
Pokharel J; Shryki I; Zwijnenburg AJ; Sandu I; Krumm L; Bekiari C; Avramov V; Heinback R; Lysell J; Eidsmo L; Harris HE; Gerlach C
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2023;34(3):394-411
Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery.
Zhao ZB; Marschner JA; Iwakura T; Li C; Motrapu M; Kuang M; Popper B; Linkermann A; Klocke J; Enghard P; Muto Y; Humphreys BD; Harris HE; Romagnani P; Anders H-J
Article: OSTEOARTHRITIS AND CARTILAGE. 2022;30(9):1198-1209
The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury
Aulin C; Larsson S; Vogl T; Roth J; Akesson A; Sward P; Heinback R; Harris HE; Struglics A
Article: BIOMOLECULES. 2022;12(6):779
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
Qu H; Heinback R; Salo H; Ewing E; Espinosa A; Aulin C; Erlandsson Harris H
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:911744
The Neuroimmune Response to Surgery - An Exploratory Study of Trauma-Induced Changes in Innate Immunity and Heart Rate Variability
Hildenborg M; Kahlin J; Granath F; Schening A; Granstrom A; Ebberyd A; Klevenvall L; Zetterberg H; Han J; Schlegel TT; Harris R; Harris HE; Eriksson LI
Article: PEDIATRIC RHEUMATOLOGY. 2021;19(1):173
Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study
Qu H; Sundberg E; Aulin C; Neog M; Palmblad K; Horne AC; Granath F; Ek A; Melen E; Olsson M; Harris HE
Article: MOLECULAR MEDICINE. 2021;27(1):58
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ
Article: BIOMOLECULES. 2021;11(6):800
Disulfide and Fully Reduced HMGB1 Induce Different Macrophage Polarization and Migration Patterns
Salo H; Qu H; Mitsiou D; Aucott H; Han J; Zhang X; Aulin C; Erlandsson Harris H
Article: MOLECULAR MEDICINE. 2021;27(1):48
Therapeutic administration of etoposide coincides with reduced systemic HMGB1 levels in macrophage activation syndrome
Palmblad K; Schierbeck H; Sundberg E; Horne A-C; Harris HE; Henter J-I; Andersson U
Article: BRITISH JOURNAL OF ANAESTHESIA. 2021;126(2):467-476
Association between cerebrospinal fluid biomarkers of neuronal injury or amyloidosis and cognitive decline after major surgery
Danielson M; Wiklund A; Granath F; Blennow K; Mkrtchian S; Nellgard B; Oras J; Fagerlund MJ; Granstrom A; Schening A; Rasmussen LS; Harris HE; Zetterberg H; Ricksten S-E; Eriksson LI
Article: PAIN. 2021;162(2):446-458
Sex-dependent role of microglia in disulfide high mobility group box 1 protein-mediated mechanical hypersensitivity
Agalave NM; Rudjito R; Farinotti AB; Khoonsari PE; Sandor K; Nomura Y; Szabo-Pardi TA; Urbina CM; Palada V; Price TJ; Harris HE; Burton MD; Kultima K; Svensson CI
Article: PAIN. 2021;162(2):459-470
Sex- and cell-dependent contribution of peripheral high mobility group box 1 and TLR4 in arthritis-induced pain
Rudjito R; Agalave NM; Farinotti AB; Lundback P; Szabo-Pardi TA; Price TJ; Harris HE; Burton MD; Svensson CI
Article: EXPERIMENTAL PHYSIOLOGY. 2020;105(9):1634-1647
The impact of damage-associated molecular patterns on the neurotransmitter release and gene expression in theex vivorat carotid body
Mkrtchian S; Kahlin J; Gomez-Galan M; Ebberyd A; Yoshitake T; Schmidt S; Kehr J; Hildenborg M; Fagerlund MJ; Harris HE; Eriksson LI
Article: OSTEOARTHRITIS AND CARTILAGE. 2020;28(5):698-707
Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA
Aulin C; Lassacher T; Palmblad K; Harris HE
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2020;38(2):355-365
Juvenile idiopathic arthritis patients have a distinct cartilage and bone biomarker profile that differs from healthy and knee-injured children
Struglics A; Saleh R; Sundberg E; Olsson M; Harris HE; Aulin C
Article: ANNALS OF NEUROLOGY. 2020;87(3):370-382
Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study
Danielson M; Wiklund A; Granath F; Blennow K; Mkrtchian S; Nellgard B; Oras J; Fagerlund MJ; Granstrom A; Schening A; Rasmussen LS; Harris HE; Zetterberg H; Ricksten S-E; Eriksson LI
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:448262
Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions
Sowinska A; Rensing M; Klevenvall L; Neog M; Lundback P; Harris HE
Article: MOLECULAR MEDICINE. 2019;25(1):13
Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation
Yang H; Liu H; Zeng Q; Imperato GH; Addorisio ME; Li J; He M; Cheng KF; Al-Abed Y; Harris HE; Chavan SS; Andersson U; Tracey KJ
Article: JOURNAL OF NEUROINFLAMMATION. 2019;16(1):45
Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1^G93A mouse model of amyotrophic lateral sclerosis
Lee JD; Liu N; Levin SC; Ottosson L; Andersson U; Harris HE; Woodruff TM
Article: MOLECULAR MEDICINE. 2018;24(1):19
Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.
Aucott H; Sowinska A; Harris HE; Lundback P
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(432):eaao1313
Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke
Roth S; Singh V; Tiedt S; Schindler L; Huber G; Geerlof A; Antoine DJ; Anfray A; Orset C; Gauberti M; Fournier A; Holdt LM; Harris HE; Engelhardt B; Bianchi ME; Vivien D; Haffner C; Bernhagen J; Dichgans M; Liesz A
Article: INNATE IMMUNITY. 2018;24(2):131-141
Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures
Olsson M; Bremer L; Aulin C; Harris HE
Article: JOURNAL OF INNATE IMMUNITY. 2018;10(3):215-227
Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms
Aucott H; Lundberg J; Salo H; Klevenvall L; Damberg P; Ottosson L; Andersson U; Holmin S; Harris HE
Article: ANNALS OF NEUROLOGY. 2017;81(4):572-582
The Immune Response of the Human Brain to Abdominal Surgery
Forsberg A; Cervenka S; Fagerlund MJ; Rasmussen LS; Zetterberg H; Harris HE; Stridh P; Christensson E; Granstrom A; Schening A; Dymmel K; Knave N; Terrando N; Maze M; Borg J; Varrone A; Halldin C; Blennow K; Farde L; Eriksson LI
Article: OSTEOARTHRITIS AND CARTILAGE. 2017;25(1):157-165
An in vivo cross-linkable hyaluronan gel with inherent anti-inflammatory properties reduces OA cartilage destruction in female mice subjected to cruciate ligament transection
Aulin C; Lundback P; Palmblad K; Klareskog L; Harris HE
Article: GERONTOLOGY. 2017;63(4):337-349
Expression of High Mobility Group Protein B1 in Cardiac Tissue of Elderly Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease
Bruton M; Hollan I; Xiao J; Lindroos E; Mikkelsen K; Rynning SE; Saatvedt K; Almdahl SM; Harris HE; Lundberg IE; Wick C
Article: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES. 2017;20(1):25-32
Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis
Ahmed AS; Ahmed M; Li J; Gu HF; Bakalkin G; Stark A; Harris HE
Article: HEPATOLOGY. 2016;64(5):1699-1710
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice
Lundback P; Lea JD; Sowinska A; Ottosson L; Furst CM; Steen J; Aulin C; Clarke JI; Kipar A; Klevenvall L; Yang H; Palmblad K; Park BK; Tracey KJ; Blom AM; Andersson U; Antoine DJ; Harris HE
Article: GENES AND IMMUNITY. 2016;17(4):261-264
LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis
Assadi G; Saleh R; Hadizadeh F; Vesterlund L; Bonfiglio F; Halfvarson J; Torkvist L; Eriksson AS; Harris HE; Sundberg E; D'Amato M
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2016;24(12):605-619
Characterization of the Inflammatory Properties of Actively Released HMGB1 in Juvenile Idiopathic Arthritis
Lundback P; Stridh P; Klevenvall L; Jenkins RE; Fischer M; Sundberg E; Andersson U; Antoine DJ; Harris HE
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:441
Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats
Terrando N; Yang T; Wang X; Fang J; Cao M; Andersson U; Harris HE; Ouyang W; Tong J
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17:338
Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease activity in systemic lupus erythematosus
Wirestam L; Schierbeck H; Skogh T; Gunnarsson I; Ottosson L; Erlandsson-Harris H; Wettero J; Sjowall C
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2015;212(1):5-14
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling
Yang H; Wang H; Ju Z; Ragab AA; Lundback P; Long W; Valdes-Ferrer SI; He M; Pribis JP; Li J; Lu B; Gero D; Szabo C; Antoine DJ; Harris HE; Golenbock DT; Meng J; Roth J; Chavan SS; Andersson U; Billiar TR; Tracey KJ; Al-Abed Y
Article: PAIN. 2014;155(9):1802-1813
Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis
Agalave NM; Larsson M; Abdelmoaty S; Su J; Baharpoor A; Lundback P; Palmblad K; Andersson U; Harris H; Svensson CI
Article: MOLECULAR MEDICINE. 2014;20(1):135-137
A Systematic Nomenclature for the Redox States of High Mobility Group Box (HMGB) Proteins
Antoine DJ; Harris HE; Andersson U; Tracey KJ; Bianchi ME
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(8):3068-3073
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation
Lu B; Antoine DJ; Kwan K; Lundback P; Wahamaa H; Schierbeck H; Robinson M; Van Zoelen MAD; Yang H; Li J; Erlandsson-Harris H; Chavan SS; Wang H; Andersson U; Tracey KJ
Article: JOURNAL OF RHEUMATOLOGY. 2013;40(9):1604-1613
HMGB1 Levels Are Increased in Patients with Juvenile Idiopathic Arthritis, Correlate with Early Onset of Disease, and Are Independent of Disease Duration
Schierbeck H; Pullerits R; Pruunsild C; Fischer M; Holzinger D; Laestadius A; Sundberg E; Harris HE
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(8):1390-1399
TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis
Zong M; Bruton JD; Grundtman C; Yang H; Li JH; Alexanderson H; Palmblad K; Andersson U; Harris HE; Lundberg IE; Westerblad H
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(5):350-360
IL-1 β/HMGB1 Complexes Promote The PGE₂ Biosynthesis Pathway in Synovial Fibroblasts
Leclerc P; Wahamaa H; Idborg H; Jakobsson PJ; Harris HE; Korotkova M
Article: EMBO JOURNAL. 2013;32(1):86-99
TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis
Nystrom S; Antoine DJ; Lundback P; Lock JG; Nita AF; Hogstrand K; Grandien A; Erlandsson-Harris H; Andersson U; Applequist SE
Article: NATURE. 2012;488(7413):670-674
Novel role of PKR in inflammasome activation and HMGB1 release
Lu B; Nakamura T; Inouye K; Li J; Tang Y; Lundback P; Valdes-Ferrer SI; Olofsson PS; Kalb T; Roth J; Zou Y; Erlandsson-Harris H; Yang H; Ting JP-Y; Wang H; Andersson U; Antoine DJ; Chavan SS; Hotamisligil GS; Tracey KJ
Journal article: MOLECULAR MEDICINE. 2012;18(2):250-259
Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1) (Publication with Expression of Concern. See vol. 26, 2020) (Retracted article. See vol. 26, 2020)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Article: MOLECULAR MEDICINE. 2012;18(2):224-230
High Mobility Group Box Protein 1 (HMGB1)-Partner Molecule Complexes Enhance Cytokine Production by Signaling Through the Partner Molecule Receptor
Hreggvidsdottir HS; Lundberg AM; Aveberger A-C; Klevenvall L; Andersson U; Harris HE
Journal article: MOLECULAR MEDICINE. 2012;18(3):545
Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1) (vol 18, pg 250, 2012)
Yang H; Lundbaeck P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Article: PAIN. 2012;153(1):18-26
Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis
Ahmed AS; Li J; Erlandsson-Harris H; Stark A; Bakalkin G; Ahmed M
Article: MOLECULAR MEDICINE. 2011;17(9-10):1039-1044
Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models
Schierbeck H; Lundback P; Palmblad K; Klevenvall L; Erlandsson-Harris H; Andersson U; Ottosson L
Article: ARTHRITIS RESEARCH & THERAPY. 2011;13(4):R136
High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts
Wahamaa H; Schierbeck H; Hreggvidsdottir HS; Palmblad K; Aveberger A-C; Andersson U; Harris HE
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(10):2963-2972
Protective Targeting of High Mobility Group Box Chromosomal Protein 1 in a Spontaneous Arthritis Model
Ostberg T; Kawane K; Nagata S; Yang H; Chavan S; Klevenvall L; Bianchi ME; Harris HE; Andersson U; Palmblad K
Article: MOLECULAR MEDICINE. 2010;16(9-10):343-351
Immunomodulatory Drugs Regulate HMGB1 Release from Activated Human Monocytes
Schierbeck H; Wahamaa H; Andersson U; Harris HE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(26):11942-11947
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
Yang H; Hreggvidsdottir HS; Palmblad K; Wang H; Ochani M; Li J; Lu B; Chavan S; Rosas-Ballina M; Al-Abed Y; Akira S; Bierhaus A; Erlandsson-Harris H; Andersson U; Tracey KJ
Article: THE FASEB JOURNAL. 2010;24(2):570-578
Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
Grundtman C; Bruton J; Yamada T; Ostberg T; Pisetsky DS; Harris HE; Andersson U; Lundberg IE; Westerblad H
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(11):3280-3289
Impaired Myofibrillar Function in the Soleus Muscle of Mice With Collagen-Induced Arthritis
Yamada T; Place N; Kosterina N; Ostberg T; Zhang S-J; Grundtman C; Erlandsson-Harris H; Lundberg IE; Glenmark B; Bruton JD; Westerblad H
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2009;86(3):655-662
The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
Hreggvidsdottir HS; Ostberg T; Wahamaa H; Schierbeck H; Aveberger A-C; Klevenvall L; Palmblad K; Ottosson L; Andersson U; Harris HE
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2009;613(1-3):155-162
Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice
Svelander L; Erlandsson-Harris H; Astner L; Grabowska U; Klareskog L; Lindstrom E; Hewitt E
Article: JOURNAL OF IMMUNOLOGY. 2009;182(11):6889-6895
TLR Activation Induces TNF-α Production from Adult Neural Stem/Progenitor Cells
Covacu R; Arvidsson L; Andersson A; Khademi M; Erlandsson-Harris H; Harris RA; Svensson MA; Olsson T; Brundin L
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;69(3):188-193
Highly Arthritis-susceptible DA Rats Express IL-1β in Articular Cartilage
Weiss RJ; Harris HE; Palmblad K
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;69(2):110-118
A Novel Anti-inflammatory Compound, Artonkin-4'-O-glucoside, from the Leaves of Artocarpus tonkinensis Suppresses Experimentally Induced Arthritis
Dang DTN; Eriste E; Liepinsh E; Trinh TT; Erlandsson-Harris H; Sillard R; Larsson P
Article: IMMUNOBIOLOGY. 2009;214(4):303-309
High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes
Sundberg E; Fasth AER; Palmblad K; Harris HE; Andersson U
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;152(1):192-199
Suppressive effects of a quinoxaline-analogue (Rob 803) on pathogenic immune mechanisms in collagen-induced arthritis
Westman E; Ngoc DDT; Klareskog L; Harris HE
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):31-38
Pivotal Advance:: Inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate
Zetterstrom CK; Jiang W; Wahamaa H; Ostberg T; Aveberger A-C; Schierbeck H; Lotze MT; Andersson U; Pisetsky DS; Harris HE
Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(1):R1
Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
Ostberg T; Wahamaa H; Palmblad K; Ito N; Stridh P; Shoshan M; Lotze MT; Harris HE; Andersson U
Article: ARTHRITIS RESEARCH & THERAPY. 2008;10(2):R33
Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients - a prospective clinical study
Sundberg E; Grundtman C; Klint EAF; Lindberg J; Ernestam S; Ulfgren A-K; Harris HE; Andersson U
Article: LUPUS. 2007;16(10):794-802
Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cutaneous lupus erythematosus
Barkauskaite V; Ek M; Popovic K; Harris HE; Wahren-Herlenius M; Nyberg F
Article: ARTHRITIS RESEARCH & THERAPY. 2007;9(2):R35
Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis
Palmblad K; Sundberg E; Diez M; Soederling R; Aveberger A-C; Andersson U; Harris HE
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(7):2289-2294
Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjogren's syndrome
Ek M; Popovic K; Harris HE; Naucler CS; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2006;145(2):339-345
Arthritogenicity of collagen type II is increased by chlorination
Westman E; Lundberg K; Harris HE
Article: CYTOKINE. 2006;34(1-2):17-23
HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages
Nowak P; Barqasho B; Treutiger CJ; Harris HE; Tracey KJ; Andersson J; Sönnerborg A
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(1):38-46
A new model for an etiology of rheumatoid arthritis
Klareskog L; Stolt P; Lundberg K; Källberg H; Bengtsson C; Grunewald J; Rönnelid J; Harris HE; Ulfgren AK; Rantapää-Dahlqvist S; Eklund A; Padyukov L; Alfredsson L
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3639-3645
Increased-expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
Popovic K; Ek M; Espinosa A; Padyukov L; Harris HE; Wahren-Herlenius M; Nyberg F
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;62(1):55-62
Morphological characterization of receptor activator of NFκB ligand (RANKL) and IL-1β expression in rodent collagen-induced arthritis
Weiss RJ; Harris HE; Wick MC; Wretenberg P; Stark A; Palmblad K
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(3):234-241
Inhibition by Artocarpus tonkinensis of the development of collagen-induced arthritis in rats
Ngoc DDT; Catrina AI; Lundberg K; Harris HE; Ha NT; Anh PT; Larsson P
Article: ANNALS OF THE RHEUMATIC DISEASES. 2005;64(3):494-496
CNI-1493, an inhibitor of proinflammatory cytokines, retards cartilage destruction in rats with collagen induced arthritis
Larsson E; Harris HE; Palmblad K; Månsson B; Saxne T; Klareskog L
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(1):1-9
RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages
Kokkola R; Andersson Å; Mullins G; Östberg T; Treutiger CJ; Arnold B; Nawroth P; Andersson U; Harris RA; Harris HE
Article: ARTHRITIS RESEARCH & THERAPY. 2005;7(3):R458-R467
Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
Lundberg K; Nijenhuis S; Vossenaar ER; Palmblad K; van Venrooij WJ; Klareskog L; Zendman AJW; Harris HE
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;60(6):566-573
Activation of human umbilical vein endothelial cells leads to relocation and release of high-mobility group box chromosomal protein 1
Mullins GE; Sunden-Cullberg J; Johansson AS; Rouhiainen A; Erlandsson-Harris H; Yang H; Tracey KJ; Rauvala H; Palmblad J; Andersson J; Treutiger CJ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2004;76(6):1118-1124
Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility
Andersson Å; Kokkola R; Wefer J; Erlandsson-Harris H; Harris RA
Article: JOURNAL OF AUTOIMMUNITY. 2004;23(2):95-102
A pH-induced modification of CII increases its arthritogenic properties
Lundberg K; Ottosson L; Westman E; Sunnerhagen M; Hultenby K; Harris HE
Article: CALCIFIED TISSUE INTERNATIONAL. 2004;75(1):50-59
Differential bone turnover in an angulated fracture model in the rat
Li J; Ahmad T; Bergström J; Samnegård E; Erlandsson-Harris H; Ahmed M; Kreicbergs A
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(5):1586-1594
Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids
Ulfgren AK; Grundtman C; Borg K; Alexanderson H; Andersson U; Harris HE; Lundberg IE
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(5):458-463
Alteration of an autoantigen by chlorination, a process occurring during inflammation, can overcome adaptive immune tolerance
Westman E; Harris HE
Article: RHEUMATOLOGY. 2004;43(4):428-434
Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP
Larsson E; Harris HE; Larsson A; Månsson B; Saxne T; Klareskog L
Article: JOURNAL OF INTERNAL MEDICINE. 2004;255(3):344-350
HMGB1 is a potent trigger of arthritis
Andersson U; Erlandsson-Harris H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(1):296-301
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
Yang H; Ochani M; Li JH; Qiang XL; Tanovic M; Harris HE; Susarla SM; Ulloa L; Wang H; DiRaimo R; Czura CJ; Wang HC; Roth J; Warren HS; Fink MP; Fenton MJ; Andersson U; Tracey KJ
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(1):297-304
Oligodeoxynucleotides containing CpG motifs can induce T cell-dependent arthritis in rats
Svelander L; Harris HE; Lorentzen JC; Trollmo C; Klareskog L; Bucht A
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;107(3):480-484
Characteristics of synovial fluid effusion in collagen-induced arthritis (CIA) in the DA rat; A comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis (RA)
Harris HE; Liljestrom M; Klareskog L
Article: JOURNAL OF INTERNAL MEDICINE. 2003;254(4):375-385
High mobility group 1 B-box mediates activation of human endothelium
Treutiger CJ; Mullins GE; Johansson ASM; Rouhiainen A; Rauvala HME; Erlandsson-Harris H; Andersson U; Yang H; Tracey KJ; Andersson J; Palmblad JEW
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(7):2052-2058
Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
Kokkola R; Li J; Sundberg E; Aveberger AC; Palmblad K; Yang H; Tracey KJ; Andersson U; Harris HE
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(6):1693-1700
High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis
Pullerits R; Jonsson IM; Verdrengh M; Bokarewa M; Anderson U; Erlandsson-Harris H; Tarkowski A
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2003;131(2):241-247
Antigen inhibition of collagen-induced arthritis is associated with up-regulation of IL-4 mRNA and induction of Ox40 on T cells in draining lymph nodes
Mattsson L; Lundberg K; Müssener E; Jansson A; Harris HE; Larsson P
Article: MOLECULAR MEDICINE. 2003;9(1-2):37-45
Structural basis for the proinflammatory cytokine activity of high mobility group box 1
Li JH; Kokkola R; Tabibzadeh S; Yang RK; Ochani M; Qiang XL; Harris HE; Czura CJ; Wang HC; Ulloa L; Wang H; Warren HS; Moldawer LL; Fink MP; Andersson U; Tracey KJ; Yang H
Article: ARTHRITIS & RHEUMATOLOGY. 2002;46(10):2598-2603
High mobility group box chromosomal protein 1 - A novel proinflammatory mediator in synovitis
Kokkola R; Sundberg E; Ulfgren AK; Palmblad K; Li J; Wang H; Ulloa L; Yang H; Yan XJ; Furie R; Chiorazzi N; Tracey KJ; Andersson U; Harris HE
Article: RHEUMATOLOGY. 2002;41(9):996-1000
Serum concentrations of cartilage oligomeric matrix protein, fibrinogen and hyaluronan distinguish inflammation and cartilage destruction in experimental arthritis in rats
Larsson E; Harris HE; Lorentzen JC; Larsson A; Månsson B; Klareskog L; Saxne T
Article: PEDIATRIC RESEARCH. 2002;52(2):148-154
High mobility group box chromosomal protein I (HMGB1) is an antibacterial factor produced by the human adenoid
Zetterström CK; Bergman T; Rynnel-Dagöö B; Harris HE; Söder O; Andersson U; Boman HG
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(1):32-41
Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-α) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats
Åkerlund K; Harris HE; Tracey KJ; Wang H; Fehniger T; Klareskog L; Andersson J; Andersson U
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;122(3):477-483
Parasite-mediated down-regulation of collagen-induced arthritis (CIA) in DA rats
Mattsson L; Larsson P; Erlandsson-Harris H; Klareskog L; Harris RA
Article: LIFE SCIENCES. 2001;69(15):1775-1782
Binding, pharmacological and immunological profiles of the δ-selective opioid receptor antagonist HS 378
Spetea M; Harris HE; Berzetei-Gurske IP; Klareskog L; Schmidhammer H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2001;158(2):491-500
Dynamics of early synovial cytokine expression in rodent collagen-induced arthritis -: A therapeutic study using a macrophage-deactivating compound
Palmblad K; Erlandsson-Harris H; Tracey KJ; Andersson U
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2000;192(4):565-570
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
Andersson U; Wang HC; Palmblad K; Aveberger AC; Bloom O; Erlandsson-Harris H; Janson A; Kokkola R; Zhang MH; Yang H; Tracey KJ
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(6):1606-1613
Role of selectins in experimental Staphylococcus aureus-induced arthritis
Verdrengh M; Erlandsson-Harris H; Tarkowski A
Article: CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY. 1997;85(1):40-46
Characterization of adhesion molecule expression in the pathogenesis of homologous collagen-induced arthritis in the DA rat
Harris HE; Liljestrom M; Lindroos E; Kleinau S
Article: IMMUNOLOGY. 1997;91(2):260-265
Polyclonal Th1 cells transfer oil-induced arthritis
Svelander L; Mussener A; ErlandssonHarris H; Kleinau S
Journal article: IMMUNOLOGY LETTERS. 1997;56(1-3):317
Adhesion molecule expression in the pathogenesis of collagen-induced arthritis
Erlandsson-Harris H
Journal article: IMMUNOLOGY LETTERS. 1997;56:317
Adhesion molecule expression in the pathogenesis of collagen-induced arthritis
Erlandsson-Harris H; Liljeström M; Kleinau S
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Conference publication: OSTEOARTHRITIS AND CARTILAGE. 2023;31:S26
ANTI-INFLAMMATORY POLYMERS AS POTENTIAL THERAPEUTICS IN KNEE OSTEOARTHRITIS
Aulin C; Melander-Bowden T; Erlandsson-Harris H; Engstrand T
Conference publication: OSTEOARTHRITIS AND CARTILAGE. 2022;30:S171-S172
INCREASED LEVELS OF HMGB1 AND S100A8/A9 IN SYNOVIAL FLUID AFTER KNEE INJURY MAY CONTRIBUTE TO OA PROGRESSION AND DISPLAY POTENTIAL THERAPEUTIC POSSIBILITIES
Aulin C; Larsson S; Vogl T; Roth J; Akesson A; Sward P; Heinback R; Erlandsson-Harris H; Struglics A
Other: MOLECULAR MEDICINE. 2020;26(1):131
High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome (Retraction of Vol 20, Pg 538, 2014)
Palmblad K; Schierbeck H; Sundberg E; Horne A-C; Harris HE; Henter J-I; Antoine DJ; Andersson U
Other: MOLECULAR MEDICINE. 2020;26(1):133
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) (Retraction of Vol 18, Pg 250, 2012)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Other: MOLECULAR MEDICINE. 2020;26(1):18
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) (Expression of Concern of Vol 18, Pg 250, 2012)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Other: MOLECULAR MEDICINE. 2020;26(1):17
High systematic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome (Expression of Concern of Vol 20, Pg 538, 2014)
Palmblad K; Schierbeck H; Sundberg E; Horne A-C; Harris HE; Henter J-I; Antoine DJ; Andersson U
Review: SEMINARS IN IMMUNOLOGY. 2018;38(C):40-48
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells
Andersson U; Yang H; Harris H
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2018;22(3):263-277
Extracellular HMGB1 as a therapeutic target in inflammatory diseases
Andersson U; Yang H; Harris H
Conference publication: OSTEOARTHRITIS AND CARTILAGE. 2016;24:S161
INTRAARTICULAR DRUG DELIVERY OF ANTI-HMGB1 IN HYALURONAN GELS FOR CARTILAGE REPAIR
Aulin C; Erlandsson-Harris H; Palmblad K; Klareskog L
Corrigendum: EMBO JOURNAL. 2013;32(1):172
TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis (vol 32, pg 86, 2013)
Nystrom S; Antoine DJ; Lundback P; Lock JG; Nita AF; Hogstrand K; Grandien A; Erlandsson-Harris H; Andersson U; Applequist SE
Conference publication: JOURNAL OF IMMUNOLOGY. 2012;188:114.7
PKR is required for NLRP3 inflammasome activation and HMGB1 release
Lu B; Nakamura T; Inouye K; Valdes-Ferrer S; Olofsson P; Li J; Wang H; Erlandsson-Harris H; Kalb T; Andersson U; Yang H; Chavan S; Hotamisligil G; Tracey K
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a81-A82
THE PRO-INFLAMMATORY EFFECT OF HMGB1, A MEDIATOR OF INFLAMMATION IN ARTHRITIS, IS DEPENDENT ON THE REDOX STATUS OF THE PROTEIN
Ottosson L; Lundback P; Hreggvidsdottir H; Yang H; Tracey KJ; Antoine DJ; Erlandsson-Harris H; Andersson U
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a43-A44
CROSSTALK BETWEEN NITROSATIVE STRESS AND ALTERED CA2⁺ HANDLING IN ARTHRITIS-INDUCED SKELETAL MUSCLE DYSFUNCTION
Bruton J; Yamada T; Ivarsson N; Grundtman C; Zhang S-J; Erlandsson-Harris H; Lundberg IE; Lanner JT; Cheng AJ; Westerblad H
Review: NATURE REVIEWS. RHEUMATOLOGY. 2012;8(4):195-202
HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
Harris HE; Andersson U; Pisetsky DS
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a77-A78
SUCCESSFUL THERAPY WITH ANTI-HMGB1 MONOCLONAL ANTIBODIES IN TWO SEPARATE EXPERIMENTAL ARTHRITIS MODELS
Schierbeck H; Lundback P; Palmblad K; Klevenvall L; Li JH; Chavan S; Yang H; Harris HE; Andersson U; Ottosson L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:A38
INTERLEUKIN 1β AND TLR LIGANDS GIVE ENHANCED CYTOKINE PRODUCTION BY THEIR INTERACTION WITH HMGB1
Hreggvidsdottir HS; Wahamaa H; Ostberg T; Schierbeck H; Aveberger A; Klevenvall L; Andersson U; Harris HE
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:36-A37
IMMUNOMODULATORY DRUGS CAN INHIBIT THE EXTRACELLULAR RELEASE OF HMGB1 FROM CULTURED HUMAN MONOCYTES
Schierbeck H; Wahamaa H; Ostberg T; Andersson U; Harris HE
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1799(1-2):141-148
The role of HMGB1 in the pathogenesis of rheumatic disease
Andersson U; Harris HE
Review: ARTHRITIS RESEARCH & THERAPY. 2008;10(3):209
High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
Pisetsky DS; Erlandsson-Harris H; Andersson U
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2008;67:A20
High mobility group box chromosomal protein-1 (HMGB-1) is expressed in idiopathic inflammatory myopathies and mediates muscle weakness
Grundtman C; Bruton J; Oestberg T; Erlandsson-Harris H; Andersson U; Westerblad H; Lundberg IE
Published conference paper: JOURNAL OF LEUKOCYTE BIOLOGY. 2007;81(1):129-136
HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay
Wahamaa H; Vallerskog T; Qin S; Lunderius C; LaRosa G; Andersson U; Harris HE
Editorial comment: EMBO REPORTS. 2006;7(8):774-778
Alarmin(g) news about danger: workshop on innate danger signals and HMGB1.
Harris HE; Raucci A
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S128
Stimulation induced secretion of the proinflammatory mediator HMGB1 by macrophages detected by ELISPOT.
Wahamaa H; Wallerskog T; Ostberg T; LaRosa G; Qin S; Andersson U; Erlandsson-Harris H
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S48-S49
Anti-rheumatic and HMGB1 blocking effects of oxaliplatin.
Ostberg T; Palmblad K; Wahamaa H; Shoshan M; Lotze M; Andersson U; Harris HE
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1503-1512
The nuclear protein HMGB1 as a proinflammatory mediator
Harris HE; Andersson U
Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2004;6:S7
Citrullinated proteins in arthritis: presence in joints and effects on immunogenicity
Lundberg K; Nijenhuis S; Vossenaar E; Klareskog L; van Venrooij WJ; Harris HE
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2003;6(10):949-950
Scandinavian Society for Immunology - 34th Annual Meeting and 19th Summer School - 24-27 August 2003, Reykjavik, Iceland
Erlandsson-Harris H; Harris R
Review: JOURNAL OF LEUKOCYTE BIOLOGY. 2002;72(6):1084-1091
HMGB1 as a DNA-binding cytokine
Andersson U; Erlandsson-Harris H; Yang H; Tracey KJ
Conference publication: BLOOD. 2002;100(11):460A
Endothelial cell release of high mobility group box (HMGB) protein-1 contributes to an autocrine loop for delayed activation.
Treutiger CJ; Mullins G; Johansson AS; Rouhiainen A; Rauvala H; Erlandsson-Harris H; Andersson U; Huan Y; Tracey K; Andersson J; Palmblad J
Conference publication: ARTHRITIS RESEARCH & THERAPY. 2001;3:p025
Dynamics of early synovial cytokine expression in rodent collagen-induced arthritis: a therapeutic study
Palmblad K; Harris HE; Tracey KJ; Andersson U
Conference publication: 2001;:a209.1-a2a209
THU0013 Biological and immunological profiles of the delta-selective opioid receptor antagonist hs 378
Spetea M; Erlandsson-Harris H; Berzetei-Gurske I; Klareskog L; Schmidhammer H
Thesis / dissertation: 1997
Studies of the immunopathogenesis in three arthritis models in rats
Erlandsson Harris, Helena
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