Hans Grönlund
Senior Forskare | Docent
E-postadress: hans.gronlund@ki.se
Besöksadress: , Stockholm
Postadress: K8 Klinisk neurovetenskap, K8 Neuro Grönlund, 171 77 Stockholm
Om mig
- Jag är docent i immunologi på Karolinska Institutet och leder sedan 2010
Enheten Terapeutisk immundesign (TID) på Institutionen för klinisk
neurovetenskap. Att sprida och fördjupa kunskap motiverar mig, i
synnerhet i multidisciplinära projekt som syftar till att omvandla basal
kunskap om vårt immunsystem, via molekylärbiologiskt framtagna molekyler
till diagnostik och botande behandling av patienter. Denna forskning har
stor betydelse för att bota multipel skleros, allergi och cancer.
Jag disputerade 2005 på Karolinska Institutet med avhandlingen ”Diagnosis
and treatment of IgE-mediated allergy: new approches using recombiant
allergens”.
Under åren 1996 - 2020 har jag publicerat 93 refereegranskade artiklar i
internationella vetenskapliga tidskrifter. Jag har även erfarenhet från
industrin och är grundare av företagen NEOGAP AB och Medi-tec AB.
Forskningsbeskrivning
- Vi designar, producerar och renar proteiner och peptider för diagnostik
och behandling inom sjukdomsområdena cancer, allergi, multipel skleros och
SARSCoV2. Inom cancer har vi utvecklat en metod för att skräddarsy
personlig behandling baserat på sekvensering, immunogen ranking
samt produktion av neoepitoper för vaccinutveckling och transfusion av
tumör-specifika autologa T-celler. Vi siktar på en klinisk prövning av
patienter med kolon eller rektalcancer under 2022.
Inom multipel skleros (MS) utnyttjar vi vår T-cellsplattform för att
identifiera nya autoantigen. Syftet är att förbättra diagnostik och
ytterst skapa botande behandling. Här samarbetar vi med renomerade forskare
inom och utom Sverige
Vi har under de senaste 20 åren forskat på förbättrad diagnostik och
behandling av pälsdjursallergi vilket resulterat i vaccinkandidater och
förbättrad diagnostik. Vi är inom alla våra projekt beroende av
fungerande samarbeten med vuxen och barnkliniker,
patientorganisationer, små och medelstora företag och forskande kolleger
runt om i världen.
Artiklar
- Journal article: CYTOTHERAPY. 2024;26(6):e26-e27
- Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1334720
- Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(12):3789-3798
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(23):16729
- Article: SCIENCE ADVANCES. 2023;9(20):eadg3032
- Article: ALLERGY. 2022;77(10):2987-3001
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(13):6984
- Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2022;12(5):e12149
- Article: SCIENCE ADVANCES. 2022;8(17):eabn1823
- Article: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY. 2022;32(2):133-140
- Article: FRONTIERS IN ONCOLOGY. 2022;12:866763
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2022;183(11):1166-1177
- Article: ISCIENCE. 2021;24(9):103078
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):207
- Article: ALLERGY. 2020;75(5):1269-1272
- Article: ALLERGY. 2019;74(12):2461-2478
- Article: JOURNAL OF AUTOIMMUNITY. 2019;102:38-49
- Article: ALLERGY. 2019;74(8):1472-1479
- Article: METHODSX. 2019;6:1635-1641
- Article: PLOS ONE. 2019;14(5):e0217208
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;142(4):1113-1120.e9
- Article: CELL. 2018;175(1):85-100.e23
- Article: ALLERGY. 2017;72(4):590-597
- Article: ALLERGY. 2016;71(10):1490-1495
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068
- Article: ALLERGY. 2016;71(9):1366-1370
- Article: RESPIRATORY RESEARCH. 2016;17(1):69
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(8):2188-2193
- Article: ALLERGY. 2015;70(12):1651-1655
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2015;191(5):574-583
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2014;25(6):558-564
- Article: RESPIRATORY MEDICINE. 2014;108(8):1234-1237
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(6):882-894
- Article: ALLERGY. 2014;69(6):708-718
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2014;25(2):187-192
- Article: METHODS. 2014;66(1):86-95
- Article: PLOS ONE. 2014;9(10):e111041
- Journal article: ALLERGY. 2013;68(11):1484-1486
- Article: JOURNAL OF IMMUNOLOGY. 2013;191(4):1529-1535
- Article: ALLERGY. 2013;68(4):549-552
- Article: ALLERGY. 2013;68(5):585-592
- Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2012;56(12):1894-1905
- Journal article: PNEUMOLOGIE. 2012;66(11)
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2012;23(4):376-384
- Article: ALLERGY. 2012;67(6):751-757
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(5):1290-1296
- Article: ALLERGY. 2012;67(5):661-669
- Article: VACCINE. 2011;29(48):8965-8973
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;127(6):1562-U375
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;127(4):1024-1028
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2011;22(1):9-18
- Article: ALLERGY. 2011;66(2):255-263
- Article: PLOS ONE. 2011;6(9):e24558
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2011;155(2):111-118
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;401(1):68-83
- Article: JOURNAL OF AUTOIMMUNITY. 2010;34(2):73-79
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2010;21(2):277-283
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2009;39(8):1199-1208
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2009;206(7):1535-1547
- Article: JOURNAL OF CARDIOVASCULAR RISK. 2009;16(3):382-386
- Article: ALLERGY. 2009;64(6):905-912
- Article: ALLERGY. 2009;64(6):919-926
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 5):467-471
- Article: ATHEROSCLEROSIS. 2009;203(2):528-532
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2008;38(12):959-965
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2008;38(8):1275-1281
- Article: LAKARTIDNINGEN. 2008;105(26-27):1942-1945
- Article: ALLERGY. 2008;63(5):518-526
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2008;146(1):1-10
- Journal article: WORLD ALLERGY ORGANIZATION JOURNAL. 2007;&NA;(&NA;):s136
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;370(4):714-727
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(3):640-645
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(2):351-358
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(1):116-124
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2006;310(1-2):117-125
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2005;138(1):59-66
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(5):657-663
- Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 2):232-234
- Article: ALLERGY. 2005;60(2):185-191
- Article: IMMUNOLOGY. 2004;113(2):253-259
- Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(6):622-623
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(2):s94-s95
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(41):40144-40151
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(39):37730-37735
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2003;132(1):25-26
- Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2003;59(Pt 6):1103-1105
- Article: IMMUNOLOGY. 2002;107(4):523-529
- Article: FEBS JOURNAL. 2002;269(11):2647-2655
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2001;108(3):409-416
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):918-928
- Article: HORMONE AND METABOLIC RESEARCH. 2000;32(4):133-138
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1999;104(5):969-977
- Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 1999;65(9):4134-4140
- Article: JOURNAL OF CLINICAL INVESTIGATION. 1999;103(11):1571-1578
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1998;102(4):579-591
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1998;213(1):87-97
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;239(1):197-204
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1996;26(12):1411-1419
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;98(3):652-658
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;97(1):385
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Alla övriga publikationer
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:482-483
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:36-37
- Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10:A685
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):234-235
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):103-104
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):233-234
- Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(9):1221-1224
- Letter: ALLERGY ASTHMA & IMMUNOLOGY RESEARCH. 2021;13(4):668-670
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):348
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):344-345
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2021;27(2_SUPPL):50-51
- Letter: ALLERGY. 2020;75(10):2668-2670
- Review: WORLD ALLERGY ORGANIZATION JOURNAL. 2020;13(5):100118
- Review: EXPERT OPINION ON BIOLOGICAL THERAPY. 2019;19(8):811-827
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(4):1658-1659
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49:746-747
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:221
- Conference publication: ALLERGY. 2019;74:223
- Conference publication: ALLERGY. 2019;74:174-175
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):340
- Conference publication: ALLERGY. 2017;72:340
- Conference publication: ALLERGY. 2016;71:190
- Conference publication: ALLERGY. 2016;71:612
- Conference publication: ALLERGY. 2016;71:397
- Conference publication: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;135(2):AB180
- Conference publication: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;135(2):AB84
- Conference publication: ALLERGY. 2015;70:517
- Conference publication: ALLERGY. 2015;70:173
- Book chapter: MOLECULAR VACCINES. 2014;p. 623-631
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):477
- Letter: ALLERGY. 2013;68(11):1485-1486
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2013;42
- Conference publication: ALLERGY. 2013;68:135-136
- Conference publication: ALLERGY. 2013;68:35
- Conference publication: ALLERGY. 2013;68:535
- Conference publication: 2012;:a1415
- Conference publication: IMMUNOLOGY. 2012;137:443
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2012;40
- Conference publication: ALLERGY. 2011;66:291-292
- Review: HUMAN VACCINES. 2010;6(12):970-977
- Review: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;151(4):265-274
- Conference publication: ALLERGY. 2010;65:105
- Conference publication: ALLERGY. 2010;65:668
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;123(5):1189-1191
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:773
- Conference publication: CLINICAL CHEMISTRY. 2009;55(6):A57
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:774
- Conference publication: CLINICAL CHEMISTRY. 2009;55(6):A58
- Conference publication: ALLERGY. 2009;64:149-150
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):78
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):78
- Conference publication: EUROPEAN HEART JOURNAL. 2008;29:628
- Conference publication: CLINICAL CHEMISTRY. 2008;54(6):A153
- Conference publication: PLACENTA. 2008;29(8):A49
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):230
- Conference publication: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2008;51(10):A343
- Conference publication: ALLERGY. 2008;63:232
- Conference publication: ALLERGY. 2008;63:223
- Conference publication: ALLERGY. 2007;62:251-252
- Conference publication: ALLERGY. 2007;62:250
- Conference publication: ALLERGY. 2007;62:249
- Conference publication: ALLERGY. 2007;62:149-150
- Conference publication: ALLERGY. 2007;62:76-77
- Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):S327
- Thesis / dissertation: 2005
- Published conference paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(Suppl 2):14677-14682
- Conference publication: ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2004;60:S174
- Conference publication: ALLERGY. 2002;57:187
- Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2000;105(1):s52
- Review: CLINICAL AND EXPERIMENTAL ALLERGY. 1999;29(7):896-904
- Published conference paper: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1999;118(2-4):116-118
- Review: BIOLOGICAL CHEMISTRY. 1999;380(7-8):815-824
- Book chapter: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1996;p. 111-116
- Book chapter: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1996;p. 185-196
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Forskningsbidrag
- Swedish Research Council1 June 2012 - 31 May 2016
Anställningar
- Senior Forskare, Klinisk neurovetenskap, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Immunologi, Karolinska Institutet, 2011
- MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2005