Hanna Dahlstrand

Ovarian cancer is the gynecological cancer that is the highest mortality. A majority of women with ovarian cancer are treated with surgery followed by chemotherapy and, in specific cases, with an anti-vascular antibody, a so-called. angiogenesis inhibitors. Preventing relapse and reducing tumor resistance to cancer treatment is necessary to improve survival in ovarian cancer. Cancer cells are highly dependent on factors in their environment. The tumor microenvironment is the cells and tissue that surround the cancer cells, such as vessels, connective tissue and immunological cells, which are important for the development of the cancer, prognosis and treatment responses. We are researching factors in the tumor microenvironment that can predict responses to angiogenesis inhibitors, or affect the resistance to chemotherapy and survival. This is to avoid giving non-effective treatment. We know today that some immune cells provide better survival in ovarian cancer. The research aims to investigate how the tumor microenvironment interacts with the immune system's cells in tumors to see if there are factors that can strengthen the immune system's work against the cancer. Our studies are conducted both in national and international collaborations. The high mortality and difficulty getting a long-term treatment response in women with spread ovarian cancer means that it is of the utmost importance to clarify markers for prognosis and treatment responses. The goal is to increase survival in the future and extend the tumor-free time for this patient group.

Ovarian cancer is the gynecological cancer that is the highest mortality. A majority of women with ovarian cancer are treated with surgery followed by chemotherapy and, in specific cases, with an anti-vascular antibody, a so-called. angiogenesis inhibitors. Preventing relapse and reducing tumor resistance to cancer treatment is necessary to improve survival in ovarian cancer. Cancer cells are highly dependent on factors in their environment. The tumor microenvironment is the cells and tissue that surround the cancer cells, such as vessels, connective tissue and immunological cells, which are important for the development of the cancer, prognosis and treatment responses. We are researching factors in the tumor microenvironment that can predict responses to angiogenesis inhibitors, or affect the resistance to chemotherapy and survival. This is to avoid giving non-effective treatment. We know today that some immune cells provide better survival in ovarian cancer. The research aims to investigate how the tumor microenvironment interacts with the immune system's cells in tumors to see if there are factors that can strengthen the immune system's work against the cancer. Our studies are conducted both in national and international collaborations. The high mortality and difficulty getting a long-term treatment response in women with spread ovarian cancer means that it is of the utmost importance to clarify markers for prognosis and treatment responses. The goal is to increase survival in the future and extend the tumor-free time for this patient group.