Göran Engberg

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Professor i farmakologi vid institutionen för fysiologi och farmakologi.

Göran Engberg är född i Ulricehamn 1952. I Uppsala läste han kurser i medicin 1975-77 och flyttade sedan till Göteborg där han började forska vid den institution som sedermera nobelpristagaren Arvid Carlsson var verksam vid. 1981 disputerade Göran Engberg vid Göteborgs universitet på en avhandling om noradrenalin i hjärnan. 1984 blev han docent i farmakologi och var under åren 1986-1995 anställd som universitetslektor i farmakologi vid Göteborgs universitet.

Göran Engberg flyttade därefter över sin forskning till Karolinska Institutet, institutionen för fysiologi och farmakologi, där han varit universitetslektor i farmakologi sedan 1995. Från 1998 är han studierektor vid KI i samma ämne.

Göran Engberg utnämndes den 1 juni 2002 till professor i farmakologi vid Karolinska Institutet.

Forskningsbeskrivning

Kynurensyra förekommer normalt i låga koncentrationer i hjärnan. Den antas bland annat ha till uppgift att reglera funktionen av den viktiga signalsubstansen glutamat genom sin förmåga att blockera glutamatreceptorerna i hjärnan. Tidigare har det visats att ämnen med denna egenskap kan framkalla samma symtom som är utmärkande vid schizofreni. En nyligen framlagd hypotes går ut på att kynurensyra som bildas efter aktivering av hjärnans immunsystem spelar en viktig roll för att utveckla sjukdomen.

Artiklar

Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2024;171:306-315
Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis
Haroon H; Ho AM-C; Gupta VK; Dasari S; Sellgren CM; Cervenka S; Engberg G; Eren F; Erhardt S; Sung J; Choi D-S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2024;17:11786469241245323
Kynurenine Metabolites in CSF and Plasma in Healthy Males
Orhan F; Schwieler L; Engberg G; Samuelsson M
Article: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2023;77(12):665-671
Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis
Pils M; Rutsch J; Eren F; Engberg G; Piehl F; Cervenka S; Sellgren C; Trossbach S; Willbold D; Erhardt S; Bannach O; Korth C
Article: ACTA NEUROPSYCHIATRICA. 2023;:1-13
Dual administration of lipopolysaccharide induces behavioural changes in rats relevant to psychotic disorders
Zheng Y-R; Tufvesson-Alm M; Trepci A; Imbeault S; Li X-Q; Schwieler L; Engberg G; Erhardt S
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2023;111:376-385
Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity
Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40
CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance
Orhan F; Goiny M; Becklen M; Mathe L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
Article: NATURE COMMUNICATIONS. 2022;13(1):6427
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia
Gracias J; Orhan F; Horbeck E; Holmen-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel IS; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yanez VAC; Gopfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Article: MOLECULAR PSYCHIATRY. 2022;27(8):3247-3261
Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
Matlik K; Garton DR; Montano-Rodriguez AR; Olfat S; Eren F; Casserly L; Damdimopoulos A; Panhelainen A; Porokuokka LL; Kopra JJ; Turconi G; Schweizer N; Bereczki E; Piehl F; Engberg G; Cervenka S; Piepponen TP; Zhang F-P; Sipila P; Jakobsson J; Sellgren CM; Erhardt S; Andressoo J-O
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):229
Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients
Shang P; Ho AM-C; Tufvesson-Alm M; Lindberg DR; Grant CW; Orhan F; Eren F; Bhat M; Engberg G; Schwieler L; Fatouros-Bergman H; Imbeault S; Iverson RM; Dasari S; Piehl F; Cervenka S; Sellgren CM; Erhardt S; Choi D-S
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6820-6832
GRK3 deficiency elicits brain immune activation and psychosis
Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schullman A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2021;14:11786469211041368
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice
Imbeault S; Gubert Olive M; Jungholm O; Erhardt S; Wigstrom H; Engberg G; Jardemark K
Article: JOURNAL OF NEUROIMMUNOLOGY. 2020;349:577401
Repeated administration of LPS exaggerates amphetamine-induced locomotor response and causes learning deficits in mice
Tufvesson-Alm M; Imbeault S; Liu X-C; Zheng Y; Faka A; Choi D-S; Schwieler L; Engberg G; Erhardt S
Article: MATERIALS CHARACTERIZATION. 2020;170:110726
Study of the alternative mechanism behind the constant strain hardening rate in high-nitrogen steels
Molnar D; Lu S; Hertzman S; Engberg G; Vitos L
Article: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE. 2020;270(7):933-938
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
Johansson V; Erhardt S; Engberg G; Kegel M; Bhat M; Schwieler L; Blennow K; Zetterberg H; Cannon TD; Wetterberg L; Hultman CM; Landen M
Article: NATURE COMMUNICATIONS. 2020;11(1):4016
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Elvsashagen T; Bahrami S; van der Meer D; Agartz I; Alnaes D; Barch DM; Baur-Streubel R; Bertolino A; Beyer MK; Blasi G; Borgwardt S; Boye B; Buitelaar J; Boen E; Celius EG; Cervenka S; Conzelmann A; Coynel D; Di Carlo P; Djurovic S; Eisenacher S; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Gelao B; Harbo HF; Hartman CA; Haberg A; Heslenfeld D; Hoekstra PJ; Hogestol EA; Jonassen R; Jonsson EG; Kirsch P; Kloszewska I; Lagerberg TV; Landro NI; Le Hellard S; Lesch K-P; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Nordvik JE; Nyberg L; O'Connell KS; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; de Quervain D; Reif A; Rokicki J; van Rooij D; Shadrin AA; Schmidt A; Schwarz E; Selbaek G; Soininen H; Sowa P; Steen VM; Tsolaki M; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Kaufmann T; Farde L; Flyckt L; Engberg G; Erhardt SS; Fatouros-Bergman H; Cervenka S; Schwieler L; Piehl F; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F; Sellgren CM
Article: IBRO REPORTS. 2020;8:136-142
CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects
Xu C; Sellgren CM; Fatouros-Bergman H; Piehl F; Blennow K; Zetterberg H; Brinkmalm A; Santillo AF; Lundgren S; Cervenka S; Engberg G; Erhardt S
Article: NATURE NEUROSCIENCE. 2019;22(10):1617-1623
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Kaufmann T; van der Meer D; Nhat TD; Schwarz E; Lund MJ; Agartz I; Alnaes D; Barch DM; Baur-Streubel R; Bertolino A; Bettella F; Beyer MK; Boen E; Borgwardt S; Brandt CL; Buitelaar J; Celius EG; Cervenka S; Conzelmann A; Cordova-Palomera A; Dale AM; de Quervain DJF; Carlo P; Djurovic S; Dorum ES; Eisenacher S; Elvsashagen T; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Haatveit B; Haberg AK; Harbo HF; Hartman CA; Heslenfeld D; Hoekstra PJ; Hogestol EA; Jernigan TL; Jonassen R; Jonsson EG; Kirsch P; Ktoszewska I; Kolskar KK; Landro NI; Hellard S; Lesch K-P; Lovestone S; Lundervold A; Lundervold AJ; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Norbom LB; Nordvik JE; Nyberg L; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; Richard G; Rokicki J; Sanders A-M; Selbaek G; Shadrin AA; Smeland OB; Soininen H; Sowa P; Steen VM; Tsolaki M; Ulrichsen KM; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Farde L; Flyckts L; Engberg G; Erhardt S; Fatouros-Bergmann H; Schwieler L; Piehl F; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: SCHIZOPHRENIA RESEARCH. 2019;210:221-227
Increased peripheral levels of TARC/CCL17 in first episode psychosis patients
Malmqvist A; Schwieler L; Orhan F; Fatouros-Bergman H; Bauer M; Flyckt L; Cervenka S; Engberg G; Piehl F; Erhardt S; Farde L; Flyckt L; Engberg G; Erhardt S; Fatouros-Bergman H; Cervenka S; Schwieler L; Piehl F; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: JAMA PSYCHIATRY. 2019;76(7):739-748
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Alnaes D; Kaufmann T; van der Meer D; Cordova-Palomera A; Rokicki J; Moberget T; Bettella F; Agartz I; Barch DM; Bertolino A; Brandt CL; Cervenka S; Djurovic S; Nhat TD; Eisenacher S; Fatouros-Bergman H; Flyckt L; Di Giorgio A; Haatveit B; Jonsson EG; Kirsch P; Lund MJ; Meyer-Lindenberg A; Pergola G; Schwarz E; Smeland OB; Quarto T; Zink M; Andreassen OA; Westlye LT; Farde L; Collste K; Victorsson P; Engberg G; Erhardt S; Malmqvist A; Hedberg M; Orhan F; Sellgren CM; Schwieler L; Piehl F
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):37
Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
Sellgren CM; Gracias J; Jungholm O; Perlis RH; Engberg G; Schwieler L; Landen M; Erhardt S
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):12
Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
Schwarz E; Nhat TD; Pergola G; Westlye LT; Kaufmann T; Wolfers T; Brecheisen R; Quarto T; Ing AJ; Di Carlo P; Gurholt TP; Harms RL; Noirhomme Q; Moberget T; Agartz I; Andreassen OA; Bellani M; Bertolino A; Blasi G; Brambilla P; Buitelaar JK; Cervenka S; Flyckt L; Frangou S; Franke B; Hall J; Heslenfeld DJ; Kirsch P; McIntosh AM; Noethen MM; Papassotiropoulos A; de Quervain DJ-F; Rietschel M; Schumann G; Tost H; Witt SH; Zink M; Meyer-Lindenberg A; Bettella F; Brandt CL; Clarke T-K; Coynel D; Degenhardt F; Djurovic S; Eisenacher S; Fastenrath M; Fatouros-Bergman H; Forstner AJ; Frank J; Gambi F; Gelao B; Geschwind L; Di Giannantonio M; Di Giorgio A; Hartman CA; Heilmann-Heimbach S; Herms S; Hoekstra PJ; Hoffmann P; Hoogman M; Jonsson EG; Loos E; Maggioni E; Oosterlaan J; Papalino M; Rampino A; Romaniuk L; Selvaggi P; Sepede G; Sonderby IE; Spalek K; Sussmann JE; Thompson PM; Vasquez AA; Vogler C; Whalley H; Farde L; Flyckt L; Engberg G; Erhardt S; Fatouros-Bergman H; Cervenka S; Schwieler L; Agartz I; Collste K; Victorsson P; Malmqvist A; Hedberg M; Orhan F
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2019;12:1178646919891169
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
Peyton L; Oliveros A; Tufvesson-Alm M; Schwieler L; Starski P; Engberg G; Erhardt S; Choi D-S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(9):644-654
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Bustillo JR; Clark VP; Agartz I; Mueller BA; Cahn W; de Zwarte SMC; Pol HEH; Kahn RS; Ophoff RA; van Haren NEM; Andreassen OA; Dale AM; Nhat TD; Gurholt TP; Hartberg CB; Haukvik UK; Jorgensen KN; Lagerberg TV; Melle I; Westlye LT; Gruber O; Kraemer B; Richter A; Zilles D; Calhoun VD; Crespo-Facorro B; Roiz-Santianez R; Tordesillas-Gutierrez D; Loughland C; Carr VJ; Catts S; Cropley VL; Fullerton JM; Green MJ; Henskens FA; Jablensky A; Lenroot RK; Mowry BJ; Michie PT; Pantelis C; Quide Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Weickert CS; Weickert TW; Morris DW; Hong E; Kochunov P; Beard LM; Gur RE; Gur RC; Satterthwaite TD; Wolf DH; Belger A; Brown GG; Ford JM; Macciardi F; Mathalon DH; O'Leary DS; Potkin SG; Preda A; Voyvodic J; Lim KO; McEwen S; Yang F; Tan Y; Tan S; Wang Z; Fan F; Chen J; Xiang H; Tang S; Guo H; Wan P; Wei D; Bockholt HJ; Ehrlich S; Wolthusen RPF; King MD; Shoemaker JM; Sponheim SR; De Haan L; Koenders L; Machielsen MW; van Amelsvoort T; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; McKenna PJ; Pomarol-Clotet E; Salvador R; Corvin A; Donohoe G; Kelly S; Whelan CD; Dickie EW; Rotenberg D; Voineskos AN; Ciufolini S; Radua J; Dazzan P; Murray R; Marques TR; Simmons A; Borgwardt S; Egloff L; Harrisberger F; Riecher-Roessler A; Smieskova R; Alpert KI; Wang L; Jonsson EG; Koops S; Sommer IEC; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Stephen JM; Kwon JS; Yun J-Y; Cannon DM; McDonald C; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Busatto GF; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; Hagenaars SP; McIntosh AM; Whalley HC; Lawrie SM; Knoechel C; Oertel-Knoechel V; Staeblein M; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; McMahon A; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2018;138(5):432-440
Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis
Orhan F; Schwieler L; Fatouros-Bergman H; Malmqvist A; Cervenka S; Collste K; Flyckt L; Farde L; Sellgren CM; Piehl F; Engberg G; Erhardt S
Article: NEUROPHARMACOLOGY. 2018;138:130-139
Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: L Check for Relevance for schizophrenia
Tufvesson-Alm M; Schwieler L; Schwarcz R; Goiny M; Erhardt S; Engberg G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(22):E5154-E5163
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Kong X-Z; Mathias SR; Guadalupe T; Glahn DC; Franke B; Crivello F; Tzourio-Mazoyer N; Fisher SE; Thompson PM; Francks C
Article: MOLECULAR PSYCHIATRY. 2018;23(5):1244-1250
CSF GABA is reduced in first-episode psychosis and associates to symptom severity
Orhan F; Fatouros-Bergman H; Goiny M; Malmqvist A; Piehl F; Cervenka S; Collste K; Victorsson P; Sellgren CM; Flyckt L; Erhardt S; Engberg G
Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;313:1-9
LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning
Oliveros A; Wininger K; Sens J; Larsson MK; Liu XC; Choi S; Faka A; Schwieler L; Engberg G; Erhardt S; Choi DS
Article: MALARIA JOURNAL. 2017;16(1):303
Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria
Holmberg D; Franzen-Rohl E; Idro R; Opoka RO; Bangirana P; Sellgren CM; Wickstrom R; Farnert A; Schwieler L; Engberg G; John CC
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2017;135(5):439-447
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium
Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santianez R; Crespo-Facorro B; Suarez-Pinilla P; Van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jorgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Jonsson EG; Hashimoto R; Yamamori H; Fukunaga M; Preda A; De Rossi P; Piras F; Banaj N; Ciullo V; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Kraemer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: ACTA NEUROPSYCHIATRICA. 2017;29(1):54-58
Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression
Liu X-C; Erhardt S; Goiny M; Engberg G; Mathe AA
Article: PSYCHIATRY RESEARCH. 2017;247:105-112
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity
Kegel ME; Johansson V; Wetterberg L; Bhat M; Schwieler L; Cannon TD; Schuppe-Koistinen I; Engberg G; Landen M; Hultman CM; Erhardt S
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;84(5):262-271
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes
Orhan F; Bhat M; Sandberg K; Stahl S; Piehl F; Svensson C; Erhardt S; Schwieler L
Article: MOLECULAR PSYCHIATRY. 2016;21(10):1342-1350
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
Sellgren CM; Kegel ME; Bergen SE; Ekman CJ; Olsson S; Larsson M; Vawter MP; Backlund L; Sullivan PF; Sklar P; Smoller JW; Magnusson PKE; Hultman CM; Walther-Jallow L; Svensson CI; Lichtenstein P; Schalling M; Engberg G; Erhardt S; Landen M
Article: NEUROCHEMICAL RESEARCH. 2016;41(9):2243-2255
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice
Larsson MK; Faka A; Bhat M; Imbeault S; Goiny M; Orhan F; Oliveros A; Stahl S; Liu XC; Choi DS; Sandberg K; Engberg G; Schwieler L; Erhardt S
Article: NEUROPHARMACOLOGY. 2016;102:42-47
Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons
Linderholm KR; Alm MT; Larsson MK; Olsson SK; Goiny M; Hajos M; Erhardt S; Engberg G
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2016;51:47-55
Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms
Aeinehband S; Brenner P; Stahl S; Bhat M; Fidock MD; Khademi M; Olsson T; Engberg G; Jokinen J; Erhardt S; Piehl F
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(2):126-133
Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia - significance for activation of the kynurenine pathway
Schwieler L; Larsson MK; Skogh E; Kegel ME; Orhan F; Abdelmoaty S; Finn A; Bhat M; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schuppe-Koistinen I; Svensson CI; Erhardt S; Engberg G
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2015;8:49-52
Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid.
Larsson MK; Schwieler L; Goiny M; Erhardt S; Engberg G
Article: MOLECULAR PSYCHIATRY. 2014;19(3):334-341
The KMO allele encoding Arg⁴⁵² is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
Lavebratt C; Olsson S; Backlund L; Frisen L; Sellgren C; Priebe L; Nikamo P; Traskman-Bendz L; Cichon S; Vawter MP; Osby U; Engberg G; Landen M; Erhardt S; Schalling M
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2014;36:80-89
Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment - Role of brain kynurenic acid
Liu X-C; Holtze M; Powell SB; Terrando N; Larsson MK; Persson A; Olsson SK; Orhan F; Kegel M; Asp L; Goiny M; Schwieler L; Engberg G; Karlsson H; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:15-22
Imbalanced kynurenine pathway in schizophrenia.
Kegel ME; Bhat M; Skogh E; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schwieler L; Engberg G; Schuppe-Koistinen I; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2013;6:89-96
Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis.
Atlas A; Franzen-Röhl E; Söderlund J; Jönsson EG; Samuelsson M; Schwieler L; Sköldenberg B; Engberg G
Article: BIPOLAR DISORDERS. 2012;14(7):719-726
Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients with bipolar I disorder
Olsson SK; Sellgren C; Engberg G; Landen M; Erhardt S
Article: SCHIZOPHRENIA BULLETIN. 2012;38(3):426-432
Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
Linderholm KR; Skogh E; Olsson SK; Dahl M-L; Holtze M; Engberg G; Samuelsson M; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2012;37(1):53-57
Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
Holtze M; Saetre P; Engberg G; Schwieler L; Werge T; Andreassen OA; Hall H; Terenius L; Agartz I; Jonsson EG; Schalling M; Erhardt S
Article: JOURNAL OF INFLAMMATION. 2011;8:25
Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts
Asp L; Johansson A-S; Mann A; Owe-Larsson B; Urbanska EM; Kocki T; Kegel M; Engberg G; Lundkvist GBS; Karlsson H
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2011;36(2):114-118
Elevation of cerebrospinal fluid interleukin-1β in bipolar disorder
Soderlund J; Olsson SK; Samuelsson M; Walther-Jallow L; Johansson C; Erhardt S; Landen M; Engberg G
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2010;35(3):195-199
Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder
Olsson SK; Samuelsson M; Saetre P; Lindstrom L; Jonsson EG; Nordin C; Engberg G; Erhardt S; Landen M
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(4):501-512
Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia
Olsson SK; Andersson AS; Linderholm KR; Holtze M; Nilsson-Todd LK; Schwieler L; Olsson E; Larsson K; Engberg G; Erhardt S
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2008;86(16):3674-3683
Induction of the Kynurenine Pathway by Neurotropic Influenza A Virus Infection
Holtze M; Asp L; Schwieler L; Engberg G; Karlsson H
Article: LIFE SCIENCES. 2008;83(5-6):170-175
Clozapine interacts with the glycine site of the NMDA receptor: Electrophysiological studies of dopamine neurons in the rat ventral tegmental area
Schwieler L; Linderholm KR; Nilsson-Todd LK; Erhardt S; Engberg G
Article: NEUROPHARMACOLOGY. 2007;53(8):918-924
Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: A pharmacological analysis
Linderholm KR; Andersson A; Olsson S; Olsson E; Snodgrass R; Engberg G; Erhardt S
Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):203-209
The kynurenic acid hypothesis of schizophrenia
Erhardt S; Schwieler L; Nilsson L; Linderholm K; Engberg G
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2007;41(1-2):144-151
Cerebrospinal fluid kynurenic acid in male and female controls -: Correlation with monoamine metabolites and influences of confounding factors
Nilsson LK; Nordin C; Jonsson EG; Engberg G; Linderholm KR; Erhardt S
Article: SYNAPSE. 2006;59(5):290-298
Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons - Possible involvement of endogenous kynurenic acid
Schwieler L; Erhardt S; Nilsson L; Linderholm K; Engberg G
Article: SCHIZOPHRENIA RESEARCH. 2005;80(2-3):315-322
Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia
Nilsson LK; Linderholm KR; Engberg G; Paulson L; Blennow K; Lindström LH; Nordin C; Karanti A; Persson P; Erhardt S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):329-339
Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms
Nilsson LK; Schwieler L; Engberg G; Linderholm KR; Erhardt S
Article: JOURNAL OF NEURAL TRANSMISSION. 2005;112(7):863-872
Prostaglandin-mediated control of rat brain kynurenic acid synthesis - opposite actions by COX-1 and COX-2 isoforms
Schwieler L; Erhardt S; Erhardt C; Engberg G
Article: BMC PSYCHIATRY. 2005;5:6
Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
Hashimoto K; Engberg G; Shimizu E; Nordin C; Lindstrom LH; Iyo M
Article: SYNAPSE. 2004;52(2):114-122
Clozapine modulates midbrain dopamine neuron firing via interaction with the NMDA receptor complex
Schwieler L; Engberg G; Erhardt S
Article: LIFE SCIENCES. 2003;72(24):2793-2801
The anaesthetic agent propofol interacts with GABA_B-receptors:: an electrophysiological study in rat
Schwieler L; Delbro DS; Engberg G; Erhardt S
Article: ACTA PHYSIOLOGICA. 2002;175(1):45-53
Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid
Erhardt S; Engberg G
Article: SYNAPSE. 2002;43(4):227-237
Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine
Erhardt S; Schwieler L; Engberg L
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2002;365(3):173-180
GABA_B receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo
Erhardt S; Mathé JM; Chergui K; Engberg G; Svensson TH
Article: NEUROSCIENCE LETTERS. 2001;313(1-2):96-98
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
Erhardt S; Blennow K; Nordin C; Skogh E; Lindström LH; Engberg G
Article: AMINO ACIDS. 2001;20(4):353-362
Pharmacological elevation of endogenous kynurenic acid levels activates nigral dopamine neurons
Erhardt S; Öberg H; Mathé JM; Engberg G
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2001;363(1):21-27
Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons
Erhardt S; Öberg H; Engberg G
Article: LIFE SCIENCES. 2000;67(15):1901-1911
Excitation of nigral dopamine neurons by the GABA_A receptor agonist muscimol is mediated via release of glutamate
Erhardt S; Engberg G
Article: SYNAPSE. 2000;37(2):104-108
Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid
Erhardt S; Hajos M; Lindberg A; Engberg G
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2000;362(1):41-45
Nicotine inhibits firing activity of dorsal raphe 5-HT neurones in vivo
Engberg G; Erhardt S; Sharp T; Hajós M
Article: JOURNAL OF NEURAL TRANSMISSION. 1999;106(5-6):383-394
Activation of nigral dopamine neurons by the selective GABA_B-receptor antagonist SCH 50911
Erhardt S; Nissbrandt H; Engberg G
Article: NEUROPSYCHOPHARMACOLOGY. 1999;20(3):287-296
Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain.
Eriksson E; Engberg G; Bing O; Nissbrandt H
Article: NEUROSCIENCE LETTERS. 1998;255(2):115-118
Oxytocin increases locus coeruleus alpha 2-adrenoreceptor responsiveness in rats
Petersson M; Uvnäs-Moberg K; Erhardt S; Engberg G
Article: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 1998;357(6):611-619
Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA_B receptors
Erhardt S; Andersson B; Nissbrandt H; Engberg G
Article: SYNAPSE. 1997;25(2):215-226
Inhibition of dopamine re-uptake: Significance for nigral dopamine neuron activity
Engberg G; Elverfors A; Jonason J; Nissbrandt H
Article: JOURNAL OF NEURAL TRANSMISSION. 1996;103(11):1255-1263
The GABA(B)-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice
Nissbrandt H; Engberg G
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Letter: BRAIN, BEHAVIOR, AND IMMUNITY. 2023;114:163-164
Preanalytic handling of clinical blood samples in assessing immunological proteins - Role of storage duration
Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855
GRK3 deficiency elicits brain immune activation and psychosis (May, 10.1038/s41380-021-01106-0, 2021)
Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hokfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landen M; Engberg G; Erhardt S
Other: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2020;23(8):543-544
OBITUARY Torgny Svensson, a superb mind and an inspiring colleague
Kasper S; Moeller H-J; Engberg G; Eriksson E; Hokfelt T
Letter: SCHIZOPHRENIA RESEARCH. 2019;208:490-492
Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis
Santillo AF; Lundgren S; Xu C; Orhan F; Fatouros-Bergman H; Blennow K; Zetterberg H; Portelius E; Cervenka S; Jonsson EG; Erhardt S; Engberg G
Letter: BIOLOGICAL PSYCHIATRY. 2019;85(7):e35-e39
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?
van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Clark VP; Mueller BA; de Zwarte SMC; Ophoff RA; van Haren NEM; Andreassen OA; Gurholt TP; Gruber O; Kraemer B; Richter A; Calhoun VD; Crespo-Facorro B; Roiz-Santianez R; Tordesillas-Gutierrez D; Loughland C; Catts S; Fullerton JM; Green MJ; Henskens F; Jablensky A; Mowry BJ; Pantelis C; Quide Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Weickert CS; Weickert TW; Hong E; Kochunov P; Gur RE; Gur RC; Ford JM; Macciardi F; Mathalon DH; Potkin SG; Preda A; Fan F; Ehrlich S; King MD; De Haan L; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; Pomarol-Clotet E; Kelly S; Ciufolini S; Radua J; Murray R; Marques TR; Simmons A; Borgwardt S; Schoenborn-Harrisberger F; Riecher-Roessler A; Smieskova R; Alpert KI; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Yun J-Y; Cannon DM; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; McIntosh AM; Whalley HC; Knoechel C; Oertel-Knoechel V; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA; Farde L; Flyckt L; Fatouros-Bergman H; Cervenka S; Collste K; Victorsson P; Engberg G; Erhardt S; Schwieler L; Malmqvist A; Hedberg M; Orhan F; Piehl F; Agartz I
Review: FRONTIERS IN PSYCHIATRY. 2019;10:963
Pharmacological Treatment in Forensic Psychiatry-A Systematic Review
Howner K; Andine P; Engberg G; Ekstrom EH; Lindstrom E; Nilsson M; Radovic S; Hultcrantz M
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441
Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients
Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Erhardt S; Wheelock CE
Letter: SCHIZOPHRENIA RESEARCH. 2018;195:406-408
First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction
Orhan F; Fatouros-Bergman H; Schwieler L; Cervenka S; Flyckt L; Sellgren CM; Engberg G; Erhardt S
Review: NEUROPHARMACOLOGY. 2017;112(Pt B):297-306
The kynurenine pathway in schizophrenia and bipolar disorder
Erhardt S; Schwieler L; Imbeault S; Engberg G
Review: LAKARTIDNINGEN. 2015;112:DH34
[New findings about schizophrenia can provide new diagnostics and treatment].
Schalling M; Engberg G; Andreassen O; Erhardt S; Cunningham J; Agartz I; Petrovic P; Cervenka S; Fatouros-Bergman H
Letter: SCHIZOPHRENIA RESEARCH. 2011;127(1-3):270-272
Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study
Holtze M; Saetre P; Erhardt S; Schwieler L; Werge T; Hansen T; Nielsen J; Djurovic S; Melle I; Andreassen OA; Hall H; Terenius L; Agartz I; Engberg G; Jonsson EG; Schalling M
Letter: MOLECULAR PSYCHIATRY. 2009;14(12):1069-1071
Activation of brain interleukin-1β in schizophrenia
Soderlund J; Schroeder J; Nordin C; Samuelsson M; Walther-Jallow L; Karlsson H; Erhardt S; Engberg G
Review: CNS DRUGS. 2009;23(2):91-101
Pharmacological Manipulation of Kynurenic Acid Potential in the Treatment of Psychiatric Disorders
Erhardt S; Olsson SK; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S2-S3
The effect of influenza A/WSN/33 virus infections on the kynurenine pathway
Asp L; Holtze M; Schwieler L; Engberg G; Karlsson H
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S422-S423
Enhanced amphetamine-induced dopamine release in rat nucleus accumbens following subchronic elevation of kynurenic acid
Andersson LA; Nilsson LK; Schwieler L; Holtze M; Olsson SK; Olsson E; Linderholm K; Engberg G; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S420-S421
Kynurenine pathway enzymes and levels of brain kynurenic acid following Influenza virus infection
Holtze M; Asp L; Engberg G; Karlsson H; Schwieler L
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S419-S420
Subchronic elevation of endogenous levels of kynurenic acid increase dopamine release in rat nucleus accumbens
Nilsson-Todd LK; Andersson LA; Schwieler L; Engberg G; Holtze M; Linderholm KR; Olsson E; Olsson SK; Erhardt S
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S219
Endogenous kynurenate regulates dopaminergic activity: implications for schizophrenia research
Erhardt S; Schwieler L; Nilsson LK; Andersson LA; Linderholm KR; Holtze M; Olsson E; Olsson SK; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S264-S265
Increased midbrain dopaminergic firing by the competitive N-methyl-D-aspartate receptor antagonist SDZ 220-581
Olsson SK; Linderholm K; Erhardt S; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S536-S537
Increased levels of kynurenic acid may account for neuropsychiatric symptoms in patients with tick-borne encephalitis
Schwieler L; Mickiene A; Holtze M; Atlas A; Engberg G
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S435-S436
The response of clozapine on midbrain dopamine neurons depends on endogenous concentration of kynurenic acid
Schwieler L; Linderholm KR; Nilsson LK; Engberg G; Erhardt S
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY AND BIOLOGICAL PSYCHIATRY. 2005;29(5):767-769
Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients
Hashimoto K; Engberg G; Shimizu E; Nordin C; Lindström LH; Iyo M
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2003;527:155-165
Kynurenic acid and schizophrenia
Erhardt S; Schwieler L; Engberg G
Published conference paper: SYNAPSE. 2001;40(4):294-301
Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: A new metabolic pathway?
Nissbrandt H; Bergquist F; Jonason J; Engberg G
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Professor, Senior, Fysiologi och farmakologi, Karolinska Institutet, 2025-2025
Professor, Fysiologi och farmakologi, Karolinska Institutet, 2002-2024

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