Fredrik Lanner

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE METHODS. 2024;:1-14
A comprehensive human embryo reference tool using single-cell RNA-sequencing data.
Zhao C; Plaza Reyes A; Schell JP; Weltner J; Ortega NM; Zheng Y; Björklund ÅK; Baqué-Vidal L; Sokka J; Torokovic R; Cox B; Rossant J; Fu J; Petropoulos S; Lanner F
Article: CYTOTHERAPY. 2024;26(4):340-350
Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells
Baque-Vidal L; Main H; Petrus-Reurer S; Lederer AR; Beri N-E; Bar F; Metzger H; Zhao C; Efstathopoulos P; Saietz S; Wrona A; Jaberi E; Willenbrock H; Reilly H; Hedenskog M; Moussaud-Lamodiere E; Kvanta A; Villaescusa JC; La Manno G; Lanner F
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2024;12:1341373
Sex-biased gene expression during neural differentiation of human embryonic stem cells
Pottmeier P; Nikolantonaki D; Lanner F; Peuckert C; Jazin E
Article: NATURE. 2023;622(7983):562-573
Complete human day 14 post-implantation embryo models from naive ES cells
Oldak B; Wildschutz E; Bondarenko V; Comar M-Y; Zhao C; Aguilera-Castrejon A; Tarazi S; Viukov S; Pham TXA; Ashouokhi S; Lokshtanov D; Roncato F; Ariel E; Rose M; Livnat N; Shani T; Joubran C; Cohen R; Addadi Y; Chemla M; Kedmi M; Keren-Shaul H; Pasque V; Petropoulos S; Lanner F; Novershtern N; Hanna JH
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):969
Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome
Chan C-H; Lam Y-Y; Wong N; Geng L; Zhang J; Ahola V; Zare A; Li RA; Lanner F; Keung W; Cheung Y-F
Article: HUMAN REPRODUCTION OPEN. 2022;2022(4):hoac043
Human endometrial cell-type-specific RNA sequencing provides new insights into the embryo-endometrium interplay
Koel M; Krjutskov K; Saare M; Samuel K; Lubenets D; Katayama S; Einarsdottir E; Vargas E; Sola-Leyva A; Lalitkumar PG; Gemzell-Danielsson K; Blesa D; Simon C; Lanner F; Kere J; Salumets A; Altmae S
Article: STEM CELL REPORTS. 2022;17(6):1458-1475
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation
Petrus-Reurer S; Lederer AR; Baque-Vidal L; Douagi I; Pannagel B; Khven I; Aronsson M; Bartuma H; Wagner M; Wrona A; Efstathopoulos P; Jaberi E; Willenbrock H; Shimizu Y; Villaescusa JC; Andre H; Sundstrom E; Bhaduri A; Kriegstein A; Kvanta A; La Manno G; Lanner F
Article: NATURE CELL BIOLOGY. 2022;24(6):845-857
Polycomb repressive complex 2 shields naive human pluripotent cells from trophectoderm differentiation
Kumar B; Navarro C; Winblad N; Schell JP; Zhao C; Weltner J; Baque-Vidal L; Salazar Mantero A; Petropoulos S; Lanner F; Elsasser SJ
Article: NATURE COMMUNICATIONS. 2021;12(1):5126
Amnion signals are essential for mesoderm formation in primates
Yang R; Goedel A; Kang Y; Si C; Chu C; Zheng Y; Chen Z; Gruber PJ; Xiao Y; Zhou C; Witman N; Leung C-Y; Chen Y; Fu J; Ji W; Lanner F; Niu Y; Chien K
Article: NATURE CELL BIOLOGY. 2021;23(1):49-60
Evaluating totipotency using criteria of increasing stringency
Posfai E; Schell JP; Janiszewski A; Rovic I; Murray A; Bradshaw B; Yamakawa T; Pardon T; El Bakkali M; Talon I; De Geest N; Kumar P; To SK; Petropoulos S; Jurisicova A; Pasque V; Lanner F; Rossant J
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2020;9(8):936-953
Preclinical safety studies of human embryonic stem cell-derived retinal pigment epithelial cells for the treatment of age-related macular degeneration
Petrus-Reurer S; Kumar P; Sanchez SP; Aronsson M; Andre H; Bartuma H; Reyes AP; Nandrot EF; Kvanta A; Lanner F
Article: STEM CELL RESEARCH. 2020;45:101810
Karolinska Institutet Human Embryonic Stem Cell Bank
Main H; Hedenskog M; Acharya G; Hovatta O; Lanner F
Article: STEM CELL REPORTS. 2020;14(4):648-662
Generation of Retinal Pigment Epithelial Cells Derived from Human Embryonic Stem Cells Lacking Human Leukocyte Antigen Class I and II
Petrus-Reurer S; Winblad N; Kumar P; Gorchs L; Chrobok M; KathleenWagner A; Bartuma H; Lardner E; Aronsson M; Reyes AP; Andre H; Alici E; Kaipe H; Kvanta A; Lanner F
Article: NATURE COMMUNICATIONS. 2020;11(1):1609
Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells
Reyes AP; Petrus-Reurer S; Sanchez SP; Kumar P; Douagi I; Bartuma H; Aronsson M; Westman S; Lardner E; Andre H; Falk A; Nandrot EF; Kvanta A; Lanner F
Article: NATURE COMMUNICATIONS. 2020;11(1):1357
Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation
Fernandez-Alonso R; Bustos F; Budzyk M; Kumar P; Helbig AO; Hukelmann J; Lamond AI; Lanner F; Zhou H; Petsalaki E; Findlay GM
Article: NATURE COMMUNICATIONS. 2020;11(1):1147
Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
Wagner M; Yoshihara M; Douagi I; Damdimopoulos A; Panula S; Petropoulos S; Lu H; Pettersson K; Palm K; Katayama S; Hovatta O; Kere J; Lanner F; Damdimopoulou P
Article: HUMAN REPRODUCTION. 2019;34(11):2297-2310
Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells
Panula S; Kurek M; Kumar P; Albalushi H; Padrell Sanchez S; Damdimopoulou P; Olofsson JI; Hovatta O; Lanner F; Stukenborg J-B
Article: NATURE COMMUNICATIONS. 2019;10(1):1636
iFISH is a publically available resource enabling versatile DNA FISH to study genome architecture
Gelali E; Girelli G; Matsumoto M; Wernersson E; Custodio J; Mota A; Schweitzer M; Ferenc K; Li X; Mirzazadeh R; Agostini F; Schell JP; Lanner F; Crosetto N; Bienko M
Article: DEVELOPMENTAL BIOLOGY. 2019;447(1):3-13
A speculative outlook on embryonic aneuploidy: Can molecular pathways be involved?
Tguiko O; Jatsenko T; Grace LKP; Kurg A; Vermeesch JR; Lanner F; Altmae S; Salumets A
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(131)
Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
Petrus-Reurer S; Bartuma H; Aronsson M; Westman S; Lanner F; Kvanta A
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(131)
Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
Petrus-Reurer S; Bartuma H; Aronsson M; Westman S; Lanner F; Kvanta A
Article: SCIENTIFIC REPORTS. 2017;7(1):9540
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching
Hildebrand S; Hultin S; Subramani A; Petropoulos S; Zhang Y; Cao X; Mpindi J; Kalloniemi O; Johansson S; Majumdar A; Lanner F; Holmgren L
Article: CELL STEM CELL. 2017;20(6):874-890.e7
Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States
Collier AJ; Panula SP; Schell JP; Chovanec P; Reyes AP; Petropoulos S; Corcoran AE; Walker R; Douagi I; Lanner F; Rugg-Gunn PJ
Article: CELL REPORTS. 2017;19(6):1101-1109
Overexpression of Trophoblast Stem Cell-Enriched MicroRNAs Promotes Trophoblast Fate in Embryonic Stem Cells
Nosi U; Lanner F; Huang T; Cox B
Article: ELIFE. 2017;6:e22906
Position-and Hippo signaling -dependent plasticity during lineage segregation in the early mouse embryo
Posfai E; Petropoulos S; de Barrosl FRO; Schell JP; Jurisica I; Sandberg R; Lanner F; Rossant J
Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2017;58(2):1314-1322
Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy
Petrus-Reurer S; Bartuma H; Aronsson M; Westman S; Lanner F; Andre H; Kvanta A
Article: NATURE BIOTECHNOLOGY. 2016;34(12):1264-1266
Single-cell sequencing of the small-RNA transcriptome
Faridani OR; Abdullayev I; Hagemann-Jensen M; Schell JP; Lanner F; Sandberg R
Article: DEVELOPMENT. 2016;143(19):3459-3469
The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation
Jouhilahti E-M; Madissoon E; Vesterlund L; Tohonen V; Krjutskov K; Reyes AP; Petropoulos S; Mansson R; Linnarsson S; Burglin T; Lanner F; Hovatta O; Katayama S; Kere J
Article: GENOME RESEARCH. 2016;26(10):1342-1354
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
Article: SCIENTIFIC REPORTS. 2016;6:28995
Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos
Madissoon E; Jouhilahti E-M; Vesterlund L; Tohonen V; Krjutskov K; Petropoulous S; Einarsdottir E; Linnarssons S; Lanner F; Mansson R; Hovatta O; Burglin TR; Katayama S; Kere J
Article: CELL. 2016;165(4):1012-1026
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Article: STEM CELL REPORTS. 2016;6(1):9-17
Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model
Reyes AP; Petrus-Reurer S; Antonsson L; Stenfelt S; Bartuma H; Panula S; Mader T; Douagi I; Andre H; Hovatta O; Lanner F; Kvanta A
Article: DEVELOPMENT. 2013;140(22):4533-4543
Location of transient ectodermal progenitor potential in mouse development
Li L; Liu C; Biechele S; Zhu Q; Song L; Lanner F; Jing N; Rossant J
Article: DEVELOPMENT. 2013;140(14):2961-2971
Porcn-dependent Wnt signaling is not required prior to mouse gastrulation
Biechele S; Cockburn K; Lanner F; Cox BJ; Rossant J
Article: STEM CELLS AND DEVELOPMENT. 2013;22(9):1360-1369
Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Lanner F; Lee KL; Ortega GC; Sohl M; Li X; Jin S; Hansson EM; Claesson-Welsh L; Poellinger L; Lendahl U; Farnebo F
Article: CELL. 2013;152(5):1008-1020
Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate
Findlay GM; Smith MJ; Lanner F; Hsiung MS; Gish GD; Petsalaki E; Cockburn K; Kaneko T; Huang H; Bagshaw RD; Ketela T; Tucholska M; Taylor L; Bowtell DD; Moffat J; Ikura M; Li SSC; Sidhu SS; Rossant J; Pawson T
Article: DEVELOPMENTAL CELL. 2012;22(4):887-901
Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells
Rugg-Gunn PJ; Cox BJ; Lanner F; Sharma P; Ignatchenko V; McDonald ACH; Garner J; Gramolini AO; Rossant J; Kislinger T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;413(3):426-431
Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling
Liu L; Lanner F; Lendahl U; Das D
Article: EMBO JOURNAL. 2011;30(9):1778-1789
Constitutive heterochromatin reorganization during somatic cell reprogramming
Fussner E; Djuric U; Strauss M; Hotta A; Perez-Iratxeta C; Lanner F; Dilworth FJ; Ellis J; Bazett-Jones DP
Article: DEVELOPMENTAL BIOLOGY. 2010;348(2):153-166
Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells
Das D; Lanner F; Main H; Andersson ER; Bergmann O; Sahlgren C; Heldring N; Hermanson O; Hansson EM; Lendahl U
Journal article: DEVELOPMENT. 2010;137(18):e1
Control of Notch-ligand endocytosis by ligand-receptor interaction
Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942
Control of Notch-ligand endocytosis by ligand-receptor interaction
Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
Article: DEVELOPMENT. 2010;137(5):715-724
FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst
Yamanaka Y; Lanner F; Rossant J
Article: STEM CELLS. 2010;28(2):191-200
Heparan Sulfation-Dependent Fibroblast Growth Factor Signaling Maintains Embryonic Stem Cells Primed for Differentiation in a Heterogeneous State
Lanner F; Lee KL; Sohl M; Holmborn K; Yang H; Wilbertz J; Poellinger L; Rossant J; Farnebo F
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;391(1):24-27
Sp1 mediate hypoxia induced ephrinB2 expression via a hypoxia-inducible factor independent mechanism
Sohl M; Lanner F; Farnebo F
Article: GENE. 2009;437(1-2):54-59
Characterization of the murine Ephrin-B2 promoter
Sohl M; Lanner F; Farnebo F
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):389-394
Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma
Geli J; Kogner P; Lanner F; Natalishvili N; Juhlin C; Kiss N; Clark GJ; Ekstrom TJ; Farnebo F; Larsson C
Article: CIRCULATION RESEARCH. 2008;102(12):1483-1491
Notch signaling regulates platelet-derived growth factor receptor-β expression in vascular smooth muscle cells
Jin S; Hansson EM; Tikka S; Lanner F; Sahlgren C; Farnebo F; Baumann M; Kalimo H; Lendahl U
Article: STEM CELLS. 2007;25(12):2987-2995
Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in Flk1-/- embryonic stem cells shows early priming of endothelial precursors
Li X; Edholm D; Lanner F; Breier G; Farnebo F; Dimberg A; Claesson-Welsh L
Article: ENDOCRINE-RELATED CANCER. 2007;14(1):125-134
The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma
Geli J; Kiss N; Lanner F; Foukakis T; Natalishvili N; Larsson O; Kogner P; Hoog A; Clark GJ; Ekstrom TJ; Backdahl M; Farnebo F; Larsson C
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2007;27(3):487-493
Functional arterial and venous fate is determined by graded VEGF signaling and notch status during embryonic stem cell differentiation
Lanner F; Sohl M; Farnebo F
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Editorial comment: STEM CELLS. 2023;41(2):105-110
The Continued Absence of Functional Germline Stem Cells in Adult Ovaries
Yoshihara M; Wagner M; Damdimopoulos A; Zhao C; Petropoulos S; Katayama S; Kere J; Lanner F; Damdimopoulou P
Letter: STEM CELLS. 2023;41(2):205-206
Reply: Revisiting Claims of the Continued Absence of Functional Germline Stem Cells in Adult Ovaries
Yoshihara M; Wagner M; Damdimopoulos A; Zhao C; Petropoulos S; Katayama S; Kere J; Lanner F; Damdimopoulou P
Editorial comment: NATURE. 2021;600(7888):223-224
A peek into the black box of human embryology
Goedel A; Lanner F
Editorial comment: CELL STEM CELL. 2021;28(9):1503-1504
Refined transcriptional blueprint of human preimplantation embryos
Weltner J; Lanner F
Review: STEM CELL REPORTS. 2021;16(5):1117-1141
All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models
Posfai E; Lanner F; Mulas C; Leitch HG
Preprint: BIORXIV. 2021
A Comprehensive Human Embryogenesis Reference Tool using Single-Cell RNA-Sequencing Data
Zhao C; Plaza Reyes A; Schell JP; Weltner J; Ortega N; Zheng Y; Björklund Å; Baqué-Vidal L; Sokka J; Torokovic R; Cox B; Rossant J; Fu J; Petropoulos S; Lanner F
Editorial comment: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2020;75(6):354-355
Single-Cell Analysis of Human Ovarian Cortex Identifies Distinct Cell Populations But No Oogonial Stem Cells
Wagner M; Yoshihara M; Douagi I; Damdimopoulos A; Panula S; Petropoulos S; Lu H; Pettersson K; Palm K; Katayama S; Hovatta O; Kere J; Lanner F; Damdimopoulou P
Review: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2018;52:1-6
Functional genetics of early human development
Ortega NM; Winblad N; Reyes AP; Lanner F
Editorial comment: CELL STEM CELL. 2018;23(2):155-157
Time Matters: Gene Editing at the Mouse 2-Cell Embryo Stage Boosts Knockin Efficiency
Reyes AP; Lanner F
Editorial comment: NATURE. 2017;548(7668):398-400
BIOTECHNOLOGY At the heart of gene edits in human embryos
Winblad N; Lanner F
Review: DEVELOPMENT. 2017;144(1):3-7
Towards a CRISPR view of early human development: applications, limitations and ethical concerns of genome editing in human embryos
Reyes AP; Lanner F
Corrigendum: CELL. 2016;167(1):285
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos (vol 165, pg 1012, 2016)
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Corrigendum: SCIENTIFIC REPORTS. 2016;6:32053
Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos (vol 6, 28995, 2016)
Madissoon E; Jouhilahti E-M; Vesterlund L; Tohonen V; Krjutskov K; Petropoulos S; Einarsdottir E; Linnarsson S; Lanner F; Mansson R; Hovatta O; Burglin TR; Katayama S; Kere J
Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(3):252-264
Single-cell RNA sequencing: revealing human pre-implantation development, pluripotency and germline development
Petropoulos S; Panula SP; Schell JP; Lanner F
Editorial comment: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2016;71(1):29-30
Adult Human and Mouse Ovaries Lack DDX4-Expressing Functional Oogonial Stem Cells EDITORIAL COMMENT
Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
Letter: NATURE MEDICINE. 2015;21(10):1116-1118
Adult human and mouse ovaries lack DDX4-expressing functional oogonial stem cells
Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
Review: EXPERIMENTAL CELL RESEARCH. 2014;321(1):32-39
Lineage specification in the early mouse embryo
Lanner F
Review: DEVELOPMENT. 2010;137(20):3351-3360
The role of FGF/Erk signaling in pluripotent cells
Lanner F; Rossant J
Thesis / dissertation: 2008
Vascular development : from embryonic stem cells to arteries and veins
Lanner, Fredrik

Forskningsbidrag

Non-invasive analysis of cellular compositions during manufacturing of stem cell products via extracellular vesicle profiling
Ming Wai Lau Centre for Reparative Medicine (MWLC)
1 January 2024 - 31 December 2026
Building the early human embryo
Swedish Research Council
1 December 2023 - 30 November 2028
Molecular mechanisms of early development
Knut and Alice Wallenberg Foundation
1 January 2015 - 1 January 2020
Mammalian preimplantation development and pluripotency –Man is not a mouse
Ragnar Söderberg Foundation
1 January 2014 - 31 December 2018
Exploring mammalian preimplantation development and pluripotency -Man is not a mouse
Swedish Research Council
1 January 2014 - 31 December 2018
Uncovering early mammalian development and pluripotency
Swedish Foundation for Strategic Research
1 September 2013 - 31 August 2016
Notification of the use of return grants for granted postdoctoral grants
Swedish Research Council
1 July 2012 - 30 June 2013
Studies on how pluripotent stem cells are regulated in the early embryo
Swedish Research Council
1 July 2009 - 30 June 2011

Anställningar

Senior Forskare, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2022-

Examina och utbildning

Medicine Doktorsexamen, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2008

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