Fredrik Lanner

Fredrik Lanner

Professor
E-postadress: fredrik.lanner@ki.se
Telefon: +46852483671
Besöksadress: Hälsovägen, Enheten för obstetrik och gynekologi C1:77, 14181 Stockholm
Postadress: H9 Klinisk vetenskap, intervention och teknik, H9 CLT Obstetrik o gynekologi Lanner, 141 52 Huddinge

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Ming Wai Lau Centre for Reparative Medicine (MWLC)
    1 January 2024 - 31 December 2026
  • Swedish Research Council
    1 December 2023 - 30 November 2028
    Understanding fundamental principles that regulate the early human embryo has clinical value for reproductive technologies, congenital disease, and regenerative medicine. My lab and others have begun to uncover the molecular mechanisms controlling the first week of development but following implantation, we have very poor understanding beyond historic histological characterisations. We have learned a lot from the mouse, but human post-implantation development is very distinct from mouse. One example, following implantation a primate specific cell type fills the blastocoel cavity prior to gastrulation, the extra embryonic mesenchyme. This cell type is completely lacking in the mouse.New opportunities to study post-implantation development has emerged through extended blastocyst cultures and stem cell-based embryo models. In this project we will build a comprehensive spatial single cell transcriptional atlas of implantation, describing the cell types and the genes that control them. This resource will be critical to validate blastoids and post-implantation embryo models. Functionally we will use the transcriptional information and validated embryo models, together with genome editing to dissect regulators of the implantation event and lineage specification of the extra embryonic mesenchyme and amnion. Lastly, we will extend our recent studies of the epigenetic control through Polycomb Repressive Complex 2, histone deacetylation and X-chromosome inactivation in female embryos.
  • Knut and Alice Wallenberg Foundation
    1 January 2015 - 1 January 2020
  • Swedish Research Council
    1 January 2014 - 31 December 2018
  • Mammalian preimplantation development and pluripotency –Man is not a mouse
    Ragnar Söderberg Foundation
    1 January 2014 - 31 December 2018
  • Uncovering early mammalian development and pluripotency
    Swedish Foundation for Strategic Research
    1 September 2013 - 31 August 2016
  • Swedish Research Council
    1 July 2012 - 30 June 2013
  • Studies on how pluripotent stem cells are regulated in the early embryo
    Swedish Research Council
    1 July 2009 - 30 June 2011

Anställningar

  • Professor, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2025-
  • Senior Forskare, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2022-2025

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2008

Nyheter från KI

Kalenderhändelser från KI