Federico Iovino | Karolinska Institutet

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: MOLECULAR MEDICINE. 2025;31(1):170
Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections
Vander Elst N; Farmen K; Knorr L; Merlijn L; Iovino F
Article: JAMA NETWORK OPEN. 2024;7(12):e2445497
Adult Work Ability Following Diagnosis of Bacterial Meningitis in Childhood
Mohanty S; Johansson Kostenniemi U; Silfverdal SA; Salomonsson S; Iovino F; Bencina G; Tsoumani E; Bruze G
Article: NEUROBIOLOGY OF DISEASE. 2024;195:106484
Spatio-temporal brain invasion pattern of Streptococcus pneumoniae and dynamic changes in the cellular environment in bacteremia-derived meningitis.
Farmen K; Tofiño-Vian M; Wellfelt K; Olsson L; Iovino F
Article: ISCIENCE. 2024;27(4):109583
The single D380 amino acid substitution increases pneumolysin cytotoxicity towards neuronal cells
Serra S; Iannotti V; Ferrante M; Tofiño-Vian M; Baxendale J; Silberberg G; Kohler TP; Hammerschmidt S; Ulijasz AT; Iovino F
Article: JAMA NETWORK OPEN. 2024;7(1):e2352402
Increased Risk of Long-Term Disabilities Following Childhood Bacterial Meningitis in Sweden.
Mohanty S; Johansson Kostenniemi U; Silfverdal SA; Salomonsson S; Iovino F; Sarpong EM; Bencina G; Bruze G
Article: MBIO. 2022;13(5):e0188622-e01822
Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis
Generoso JS; Thorsdottir S; Collodel A; Dominguini D; Santo RRE; Petronilho F; Barichello T; Iovino F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(23):e2122386119
Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA
Narciso AR; Iovino F; Thorsdottir S; Mellroth P; Codemo M; Spoerry C; Righetti F; Muschiol S; Normark S; Nannapaneni P; Henriques-Normark B
Article: PLOS PATHOGENS. 2021;17(3):e1009432
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin
Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Srambickal CV; Widengren J; Henriques-Normark B; Iovino F
Article: EMBO MOLECULAR MEDICINE. 2020;12(11):e12695
Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease
Subramanian K; Iovino F; Tsikourkitoudi V; Merkl P; Ahmed S; Berry SB; Aschtgen M-S; Svensson M; Bergman P; Sotiriou GA; Henriques-Normark B
Article: CHEMICAL COMMUNICATIONS. 2020;56(51):6989-6992
Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions
Iovino F; Merkl P; Spyrogianni A; Henriques-Normark B; Sotiriou GA
Article: BIOSENSORS & BIOELECTRONICS. 2019;132:286-293
Luminescent CeO₂:Eu³⁺ nanocrystals for robust in situ H₂O₂ real-time detection in bacterial cell cultures
Henning DF; Merkl P; Yun C; Iovino F; Xie L; Mouzourakis E; Moularas C; Deligiannakis Y; Henriques-Normark B; Leifer K; Sotiriou GA
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:195-202
IVIS Spectrum CT to Image the Progression of Pneumococcal Infections In Vivo.
Sierakowiak A; Henriques-Normark B; Iovino F
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:173-181
In Vivo Mouse Models to Study Pneumococcal Host Interaction and Invasive Pneumococcal Disease.
Iovino F; Sender V; Henriques-Normark B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:53-59
High-Resolution and Super-Resolution Immunofluorescent Microscopy Ex Vivo to Study Pneumococcal Interactions with the Host.
Iovino F; Henriques-Normark B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:35-39
Immunofluorescent Staining and High-Resolution Microscopy to Study the Pneumococcal Cell.
Iovino F; Henriques-Normark B
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):476-484
Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion
Iovino F; Thorsdottir S; Henriques-Normark B
Article: MBIO. 2018;9(2):e00559-e00518
Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses
Codemo M; Muschiol S; Iovino F; Nannapaneni P; Plant L; Wai SN; Henriques-Normark B
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(6):1619-1630
pIgR and PEC AM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion
Iovino F; Engelen-Lee J-Y; Brouwer M; van de Beek D; van der Ende A; Seron MV; Mellroth P; Muschiol S; Bergstrand J; Widengren J; Henriques-Normark B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(8):2821-2826
Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA
Iovino F; Hammarlof DL; Garriss G; Brovall S; Nannapaneni P; Henriques-Normark B
Article: INFECTION AND IMMUNITY. 2014;82(9):3555-3566
Platelet Endothelial Cell Adhesion Molecule-1, a Putative Receptor for the Adhesion of Streptococcus pneumoniae to the Vascular Endothelium of the Blood-Brain Barrier
Iovino F; Molema G; Bijlsma JJE
Article: MBIO. 2014;5(4):e00984-e00914
The Proteasome-Ubiquitin System Is Required for Efficient Killing of Intracellular Streptococcus pneumoniae by Brain Endothelial Cells
Iovino F; Gradstedt H; Bijlsma JJ
Article: PLOS ONE. 2014;9(5):e97914
Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor
Iovino F; Molema G; Bijlsma JJE
Article: PLOS ONE. 2013;8(7):e68408
Interactions between Blood-Borne Streptococcus pneumoniae and the Blood-Brain Barrier Preceding Meningitis
Iovino F; Orihuela CJ; Moorlag HE; Molema G; Bijlsma JJE
Article: PLOS ONE. 2013;8(6):e65626
Streptococcus pneumoniae Invades Endothelial Host Cells via Multiple Pathways and Is Killed in a Lysosome Dependent Manner
Gradstedt H; Iovino F; Bijlsma JJE
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Alla övriga publikationer

Preprint: BIORXIV. 2023
Spatio-temporal brain invasion pattern of Streptococcus pneumoniae and dynamic changes of the cellular environment in meningitis pathogenesis
Farmen K; Tofiño-Vian M; Wellfelt K; Olson L; Iovino F
Review: FRONTIERS IN NEUROLOGY. 2023;14:822575
Bacterial meningitis in Africa.
Barichello T; Rocha Catalão CH; Rohlwink UK; van der Kuip M; Zaharie D; Solomons RS; van Toorn R; Tutu van Furth M; Hasbun R; Iovino F; Namale VS
Book: 2022
Encyclopedia of Infection and Immunity
Preprint: BIORXIV. 2022
Dysfunctional glymphatic system with disrupted aquaporin-4 expression pattern on astrocytes causes bacterial product accumulation in the CSF during pneumococcal meningitis
Generoso JS; Thorsdottir S; Collodel A; Dominguini D; Santo RRE; Petronilho F; Barichello T; Iovino F
Editorial comment: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:790761
Editorial: Host-Pathogen Interaction in the Central Nervous System
Barichello T; Iovino F
Review: FRONTIERS IN CELLULAR NEUROSCIENCE. 2021;15:680858
Neuronal Damage and Neuroinflammation, a Bridge Between Bacterial Meningitis and Neurodegenerative Diseases
Farmen K; Tofino-Vian M; Iovino F
Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(5):539-540
Experimental Model for Studies of Pneumococcal Colonization in Older Adults
Iovino F; Henriques-Normark B
Preprint: BIORXIV. 2020
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and pilus-1 interactions with β-actin
Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Henriques-Normark B; Iovino F
Review: MOLECULAR MICROBIOLOGY. 2020;113(3):650-658
The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease
Iovino F; Nannapaneni P; Henriques-Normark B; Normark S
Book: 2019
Streptococcus pneumoniae Methods and Protocols
Iovino F
Review: FRONTIERS IN MICROBIOLOGY. 2019;10:576
The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies
Thorsdottir S; Henriques-Normark B; Iovino F
Review: TRENDS IN MICROBIOLOGY. 2016;24(4):307-315
How Does Streptococcus pneumoniae Invade the Brain?
Iovino F; Seinen J; Henriques-Normark B; van Diji JM
Review: CELLULAR MICROBIOLOGY. 2013;15(6):870-881
Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease
Iovino F; Brouwer MC; van de Beek D; Molema G; Bijlsma JJEY

Forskningsbidrag

Medicin 2025, projektmedel
ALF (Region Stockholm)
1 January 2025 - 31 December 2024
Åhlén Foundation
Åhlén-stiftelsen
1 January 2025
Engineered endolysins to fight antibiotic-resistant streptococcal infections and neutralize toxins
Vetenskapsrådet
1 January 2025 - 31 December 2026
Project Grant
Gun & Bertil Stohnes Stiftelse
1 January 2025
Etablering av en ny neuroprotektiv terapi för att förhindra hörselnedsättning orsakad av hjärninfektioner
Etablering av en ny neuroprotektiv terapi för att förhindra hörselnedsättning orsakad av hjärninfektioner
1 June 2024
Supporting innovators to fight drug-resistant infections
INCATE
1 May 2024
Blockering av bakteriell interaktion med neuroner: en ny terapeutisk strategi för att förhindra permanent neurologisk skada orsakad av hjärninfektioner
Magnus Bergvall Foundation
1 February 2024
The bacteria-neuron blockade, the FIRST therapeutic approach to prevent permanent neurological damage caused by infections
Gun & Bertil Stohnes Stiftelse
1 January 2024
Förebyggande av neurologiska funktionshinder orsakade av perinatala hjärninfektioner
Åhlén-stiftelsen
1 January 2024
Novel fusion proteins with bacteriocidic, anti-neurotoxic and antibiotic synergistic properties to improve pneumococcal meningitis treatment
H.K.H. Kronprinsessan Lovisas förening för barnasjukvård
1 November 2023 - 1 November 2024
Förhindra permanent allvarlig hörselnedsättning orsakad av hjärninfektioner
Stiftelsen Tysta Skolan
1 May 2023
En ny terapeutisk metod för att förhindra permanent neurologisk funktionsnedsättning hos spädbarn och barn som drabbats av hjärninfektioner
Wera Ekströms stiftelse för pediatrisk forskning
1 February 2023
Bakteriell interaktion med neuroner: ett nytt terapeutiskt mål mot hjärninfektioner
Magnus Bergvalls Stiftelse
1 February 2023
Blockade of pneumococcal‐neuron interaction to prevent neuronal damage in bacterial meningitis
European Society of Clinical Microbiology and Infectious Diseases
1 January 2023 - 1 January 2024
Establishment of the first therapeutic approach to prevent permanent neurological disabilities caused by brain bacterial infections
Bjarne Alhströms Minnesfond
1 January 2023
Förebyggande av neurologiska funktionshinder orsakade av perinatala hjärninfektioner
Åhlén-stiftelsen
1 January 2023
Bakteriell interaktion med neuroner: ett nytt terapeutiskt mål mot hjärninfektioner
Magnus Bergvalls Stiftelse
1 January 2022
Förhindra irreparabel neurologisk skada efter bakteriell meningit genom att blockera patogeninteraktion med neuroner
Tore Nilsons Stiftelse
1 January 2022
Förhindra neuronal förlust som leder till Parkinsons och Alzheimers sjukdomar
Stiftelsen för Gamla Tjänarinnor
1 May 2021
Bacterial meningitis: Understanding bacterial interactions with neurons and microglia to develop new approaches to prevent neuronal damage and reinforce the brain´s immune system.
Swedish Research Council
1 January 2021 - 31 December 2024
Förhindra irreparabel neurologisk skada efter bakteriell meningit genom att blockera patogeninteraktion med neuroner
Magnus Bergvalls Stiftelse
1 January 2021
Bakteriell meningit: Förstå bakteriella interaktioner med mikroglia och nervceller för att utveckla nya metoder för att öka hjärnans immunsystem och förhindra neuronal skada
Tore Nilsons Stiftelse
1 January 2021
Understanding bacterial invasion of the brain: Interactions of Streptococcus pneumoniae with microglia and neurons.
Åke Wiberg Foundation
1 January 2020
Understanding bacterial invasion of the brain
Loo & Hans Osterman Foundation
1 November 2019
Start-up Grant
StratNeuro
1 June 2019
Bakteriell meningit: Förstå bakteriella interaktioner med mikroglia och nervceller för att utveckla nya metoder för att öka hjärnans immunsystem och förhindra neuronal skada
Petrus and Augusta Hedlund Foundation
1 June 2019
Block pneumococcal-neuron interaction to protect neurons from bacterial infections
Clas Groschinskys Minnesfond
1 June 2019
Förbättra antimikrobiella behandlingar hos cancerpatienter.
Jeanssons Stiftelser
1 January 2019
New therapeutic and prophylactic strategies to cure and prevent bacterial meningitis
HKH Kronprinsessan Lovisas förening för barnasjukvård
1 January 2019
New therapeutic strategies to cure and prevent bacterial meningitis State
Karolinska Institutet Research Foundations
1 January 2019
Brain cancer and bacterial meningitis: how to prevent bacterial penetration of the blood-brain barrier in patients with brain cancer.
Åke Wibergs Stiftelse
1 January 2019
Faculty-funded Assistant Professor position
Karolinska Institutet
3 December 2018
Bakteriell meningit: Molekylära mekanismer för bakteriell inträde i hjärnan över blod-hjärnbarriären och nya terapeutiska metoder för att blockera det.
Petrus och Augusta Hedlunds Stiftelse
1 June 2018
Bacterial meningitis: Understanding bacterial invasion of the brain
Fredrik och Ingrid Thurings Stiftelse
1 January 2018
New therapeutic strategies to cure and prevent bacterial meningitis
Jeanssons Stiftelser
1 January 2018
New therapeutic strategies to cure and prevent bacterial meningitis
Åke Wibergs Stiftelse
1 January 2018
Etablering av en ny neuroprotektiv terapi för att förhindra hörselnedsättning orsakad av hjärninfektioner
Stiftelsen Tysta Skolan
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Anställningar

Senior Forskare, Neurovetenskap, Karolinska Institutet, 2023-
Postdoctoral researcher, Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 2013-2015

Examina och utbildning

Docent, Medicinsk mikrobiologi, Karolinska Institutet, 2021
PhD degree, Medical Microbiology, Medical Microbiology, University of Groningen, 2013

Uppdrag

Sektionsansvarig, Principal Investigator representative, Neuroscience, Karolinska Institutet, 2022-
Sektionsansvarig, Safety representative, Neuroscience, Karolinska Institutet, 2022-

Priser och utmärkelser

World Expert Recognition, Expertscape, https://nyheter.ki.se/federico-iovino-utsedd-till-world-expert-av-expertscape, 2021
Prize for research in Clinical Neurology, Bjarne Ahlström Memorial Fund, https://news.ki.se/federico-iovino-awarded-the-bjarne-ahlstrom-minnesfonds-pris-2020-for-research-in-clinical, 2020

Handledning

Handledning till doktorsexamen
- Simona Serra, 2023-
- Kristine Farmen, 2021-
Handledning av postdoktorala forskare
- Niels Vander Elst, 2023-
- Miguel Tofiño-Vian, 2021-

Redaktör för vetenskaplig tidskrift

"In vitro and In vivo models for CNS infections", part of the “Methods in Molecular Biology” series, Chefredaktör, 2022
Frontiers in Cellular and Infection Microbiology, Medlem i redaktionskommittén, 2021
Section Clinical Infectious Diseases, Encyclopedia of Infection and Immunity (Elsevier), Biträdande redaktör, https://www.sciencedirect.com/referencework/9780323903035/encyclopedia-of-infection-and-immunity, 2020
"Streptococcus pneumoniae", part of the “Methods in Molecular Biology” series, Chefredaktör, https://www.springer.com/gp/book/9781493991983, 2018

Sakkunniggranskning för vetenskaplig tidskrift

Nature Communications, Cell Systems, PNAS, eBioMedicine (The Lancet), Scientific Reports (Nature publishing group), BMC Journal of Biomedical Science, PLOS One, Journal of Neuroinflammation, Molecular Neurobiology, Brain Research, Cellular and Molecular Neurobiology, Journal of Neuroimmunology, Neurotoxicology and Teratology, Neuroscience Letters, Journal of Innate Immunity, Journal of Immunology, mBio (American Society of Microbiology), PLOS Pathogens, Infection & Immunity, Molecular Microbiology, Journal of Bacteriology, The International Journal of Medical Microbiology, Microbiology (Microbiology Society), Microbial Pathogenesis, Pathogens and Disease (FEMS), Virulence, Frontiers in Cellular and Infection Microbiology, Frontiers in Immunology, Frontiers in Pediatrics, Frontiers in Bioengineering and Biotechnology, Current Research in Microbial Sciences, Infection and Drug Resistance, Heliyon (Cell Press), Experimental and Molecular Pathology, Annals of Medicine, BMJ (British Medical Journal) Case Reports, Journal of Pediatric Infectious Disease Society., Anonymous peer review, 2018

Expert

Evaluator of research applications in international competition, Grant reviewer / Evaluation panel member, European Society of Clinical Microbiology and Infectious Diseases, 2021

Nyheter från KI

Kalenderhändelser från KI