Eric Herlenius
About me
To Breathe or not to Breathe, that is the question!
Focus on perinatal development of Inspiration and autonomic control & how novel deep machine learning of vital parameter data better the diagnostics and treatment of newborn, children and adult patients
Eric Herlenius studied medicine at Karolinska Institutet where he also defended his PhD thesis in developmental neuroscience 1998. He subsequently joined Profs Iku Homma and Evan Snyder for postdoc at Showa University, Tokyo and Children’s Hospital, Harvard medical school, Boston respectively, to study activity dependent development and plasticity of functional neural networks. He then specialized in Pediatrics and continued investigations regarding perinatal development of autonomic control. He is a Physician-scientist focused on translational medicine, combining basic mechanistic and patient research to develop novel methods to screen, detect and protect against inflammation related breathing disorders.
Current positions and commitments
- Professor of Pediatrics, Karolinska Institutet
- Senior Consultant in Pediatrics, Astrid Lindgren´s Children´s Hospital
- Chair Research - Development and education for Pediatric Emergency and Infectious disease, Karolinska University Hospital
- Head, Perinatology course Medical Students, KI
- Head DeepNEWS - Deep machine learning based Novel Early Warning System. KI-K-KTH
Research
- Immature respiratory control in infants born may result in apneas, sudden unexpected postnatal collapse (SUPC), secondary hypoxic brain damage, and SIDS. We have shown that prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response. This has led us to focus on the role of inflammation and brainstem modulation in both clinical and mechanistic studies. These are used to define mechanisms for factors disturbing the physiological and neural pathways that control breathing. Main goals are:
1) Develop better clinical guidelines and best practices to prevent sudden cardiorespiratory failure in newborns, Sudden Unexpected Postnatal Collapse (SUPC).
2) Deep-NEWS! To clinically characterize how dysregulation of respiratory control induces life-threatening events and if subtle alterations in cardiorespiratory parameters may act as early warning scores for infection, inflammation and a need for therapeutic intervention. We use Deep Machine Learning based analysis of individual patients real time vital parameters to develop rapid semiautomatic Novel Early Warning Systems.
3) To define the pathophysiological mechanism of apneas and involvement of inflammation in the development and activity of brainstem respiration-related neural circuits. In vivo and novel in vitro experimental mouse models and single cell transcriptomics and patch-seq techniques are used.
By complimenting a thorough understanding of the ways in which inflammation impacts breathing and understanding cues that precede respiratory failure, we will enable earlier and novel therapeutic interventions before life-threatening events occur.
Teaching
Head and Organizer of Elective course MD-program Perinatology (7.5 p) 2009-2023
Head and Organizer of PhD-course in Perinatology (7.5 p) 2016-2018
Head and Organizer of Pediatric-resident-course in Perinatology (1.5 p) 2016-2018
Co-organizer course MD-program Pediatric Emergency Medicine (7.5 p) 2019-
Articles
- Article: FRONTIERS IN MEDICINE. 2025;12:1602129Murzabekov M; Lidstromer N; Borg N; Runold M; Herlenius E; Rautiainen S
- Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025;26(12):5591Tran NT; Stojanovska V; Kelly SB; Vidinopoulos K; Atta J; Matthews-Staindl E; Zahra VA; Pham Y; Herlenius EAP; Hooper SB; Allison BJ; Galinsky R; Polglase GR
- Journal article: BIOETHICS OPEN RESEARCH. 2025;2:3Lidströmer N; Kanters JJ; Herlenius E
- Journal article: BIOETHICS OPEN RESEARCH. 2024;2:3Lidströmer N; Herlenius E
- Journal article: BIOETHICS OPEN RESEARCH. 2024;2:3Lidströmer N; Herlenius E
- Journal article: BMC DIGITAL HEALTH. 2024;2(1):76Lidstromer N; Davids J; Elsharkawy M; Ashrafian H; Herlenius E
- Journal article: BMC DIGITAL HEALTH. 2024;2(1):75Davids J; ElSharkawy M; Ashrafian H; Herlenius E; Lidstromer N
- Journal article: BMC DIGITAL HEALTH. 2024;2(1):51Lidstromer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1408607Reising JP; Gonzalez-Sanchez AC; Samara A; Herlenius E
- Article: STAR PROTOCOLS. 2024;5(1):102908Phillips WS; Ramadan N; Samara A; Herlenius E
- Article: NATURE COMMUNICATIONS. 2024;15(1):2186Lidströmer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
- Article: FRONTIERS IN PEDIATRICS. 2023;11:1225294Vidinopoulos K; Azman Z; Somers A; Zahra VA; Thiel A; Lu H; Pham Y; Tran NT; Allison BJ; Herlenius E; Hooper S; Galinsky R; Polglase GR
- Article: ACTA PAEDIATRICA. 2023;112(7):1443-1452Stalhammar AM; Honore A; Adolphson K; Forsberg D; Herlenius E; Jost K
- Article: ACTA PAEDIATRICA. 2023;112(4):686-696Honore A; Forsberg D; Adolphson K; Chatterjee S; Jost K; Herlenius E
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
- Article: FRONTIERS IN PEDIATRICS. 2022;10:921444Leifsdottir K; Jost K; Siljehav V; Thelin EP; Lassaren P; Nilsson P; Haraldsson A; Eksborg S; Herlenius E
- Article: FRONTIERS IN NEURAL CIRCUITS. 2022;16:826497Reising JP; Phillips WS; Ramadan N; Herlenius E
- Article: ACTA PAEDIATRICA. 2022;111(5):961-970Leifsdottir K; Thelin EP; Lassaren P; Siljehav V; Nilsson P; Eksborg S; Herlenius E
- Article: FRONTIERS IN PHYSIOLOGY. 2022;13:841229Stojanovska V; Atta J; Kelly SB; Zahra VA; Matthews-Staindl E; Nitsos I; Moxham A; Pham Y; Hooper SB; Herlenius E; Galinsky R; Polglase GR
- Article: ACTA PAEDIATRICA. 2021;110(10):2802-2804Rhedin SA; Rinder MR; Hildenwall H; Herlenius E; Hertting O; Luthander J; Melen E; Nijman R; Olsson-Akefeldt S; Alfven T
- Article: FRONTIERS IN PHYSIOLOGY. 2021;11:624625Samara A; Herlenius E
- Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):312Becker M; Mastropasqua F; Reising JP; Maier S; Ho M-L; Rabkina I; Li D; Neufeld J; Ballenberger L; Myers L; Moritz V; Kele M; Wincent J; Willfors C; Sitnikov R; Herlenius E; Anderlid B-M; Falk A; Bolte S; Tammimies K
- Article: ACTA PAEDIATRICA. 2019;108(10):1879-1886Hamrin J; Perez-Manzo M; Idborg H; Jakobsson P-J; Bjork L; Eriksson M; Nilsson A; Herlenius E
- Article: FRONTIERS IN PHYSIOLOGY. 2019;10:307Stalnacke SR; Tessma M; Bohm B; Herlenius E
- Article: JOURNAL OF NEUROINFLAMMATION. 2018;15(1):223Leifsdottir K; Mehmet H; Eksborg S; Herlenius E
- Article: PEDIATRICS. 2018;141(5):e20174047Muerner-Lavanchy IM; Doyle LW; Schmidt B; Roberts RS; Asztalos EV; Costantini L; Davis PG; Dewey D; D'Ilario J; Grunau RE; Moddemann D; Nelson H; Ohlsson A; Solimano A; Tin W; Anderson PJ
- Article: ELIFE. 2017;6:e29566Forsberg D; Ringstedt T; Herlenius E
- Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2017;42:2D.13.1-2D.13.30Forsberg D; Thonabulsombat C; Jäderstad J; Jäderstad LM; Olivius P; Herlenius E
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(32):E6603-E6612Dyberg C; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Olsen TK; Forsberg D; Herlenius E; Martinsson T; Brodin B; Kogner P; Johnsen JI; Wickstrom M
- Article: JAMA PEDIATRICS. 2017;171(6):564-572Schmidt B; Roberts RS; Anderson PJ; Asztalos EV; Costantini L; Davis PG; Dewey D; D'Ilario J; Doyle LW; Grunau RE; Moddemann D; Nelson H; Ohlsson A; Solimano A; Tin W
- Article: ELIFE. 2016;5:e14170Forsberg D; Horn Z; Tserga E; Smedler E; Silberberg G; Shvarev Y; Kaila K; Uhlen P; Herlenius E
- Article: ARCHIVES DE PEDIATRIE. 2016;23(3):234-240Boubred F; Herlenius E; Andres V; des Robert C; Marchini G
- Article: JOURNAL OF PEDIATRICS. 2015;167(6):1207-13.e3Siljehav V; Hofstetter AM; Leifsdottir K; Herlenius E
- Article: JOURNAL OF PEDIATRICS. 2015;167(5):982-6.e2Schmidt B; Roberts RS; Davis PG; Doyle LW; Asztalos EV; Opie G; Bairam A; Solimano A; Arnon S; Sauve RS
- Article: ACTA PAEDIATRICA. 2015;104(11):1077-1083Boubred F; Herlenius E; Bartocci M; Jonsson B; Vanpee M
- Article: NEUROREPORT. 2015;26(15):928-936Ravella A; Ringstedt T; Brion J-P; Pandolfo M; Herlenius E
- Article: ARCHIVES OF DISEASE IN CHILDHOOD. 2015;100(8):748-753Synnes A; Anderson PJ; Grunau RE; Dewey D; Moddemann D; Tin W; Davis PG; Doyle LW; Foster G; Khairy M; Nwaesei C; Schmidt B
- Article: JOURNAL OF PEDIATRICS. 2015;166(4):870-6.e1-2-U158Manley BJ; Roberts RS; Doyle LW; Schmidt B; Anderson PJ; Barrington KJ; Bohm B; Golan A; van Wassenaer-Leemhuis AG; Davis PG
- Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275Idborg H; Pawelzik S-C; Perez-Manso M; Bjork L; Hamrin J; Herlenius E; Jakobsson P-J
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2014;117(9):1027-1036Siljehav V; Shvarev Y; Herlenius E
- Article: JOURNAL OF PEDIATRICS. 2014;165(2):356-359.e2Doyle LW; Schmidt B; Anderson PJ; Davis PG; Moddemann D; Grunau RE; O'Brien K; Sankaran K; Herlenius E; Roberts R
- Article: ACTA PAEDIATRICA. 2013;102(11):1041-1047Bjork L; Leifsdottir K; Saha S; Herlenius E
- Article: ACTA PAEDIATRICA. 2013;102(7):680-688Pejovic NJ; Herlenius E
- Article: TRANSLATIONAL STROKE RESEARCH. 2013;4(2):236-247Herlenius E; Kuhn P
- Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2012;Chapter 2:Unit-2D.13Herlenius E; Thonabulsombat C; Forsberg D; Jäderstad J; Jäderstad LM; Björk L; Olivius P
- Article: PEDIATRIC RESEARCH. 2012;72(5):460-467Siljehav V; Hofstetter AO; Jakobsson P-J; Herlenius E
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):448-454Ambrosi A; Dzikaite V; Park J; Strandberg L; Kuchroo VK; Herlenius E; Wahren-Herlenius M
- Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2012;307(3):275-282Schmidt B; Anderson PJ; Doyle LW; Dewey D; Grunau RE; Asztalos EV; Davis PG; Tin W; Moddemann D; Solimano A; Ohlsson A; Barrington KJ; Roberts RS
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;90(1):152-160Heron SE; Grinton BE; Kivity S; Afawi Z; Zuberi SM; Hughes JN; Pridmore C; Hodgson BL; Iona X; Sadleir LG; Pelekanos J; Herlenius E; Goldberg-Stern H; Bassan H; Haan E; Korczyn AD; Gardner AE; Corbett MA; Gecz J; Thomas PQ; Mulley JC; Berkovic SF; Scheffer IE; Dibbens LM
- Article: JOURNAL OF PEDIATRICS. 2011;159(4):546-50.e1DeMauro SB; Roberts RS; Davis P; Alvaro R; Bairam A; Schmidt B
- Article: PEDIATRICS. 2011;127(1):e146-e155Dukhovny D; Lorch SA; Schmidt B; Doyle LW; Kok JH; Roberts RS; Kamholz KL; Wang N; Mao W; Zupancic JAF
- Article: EXPERIMENTAL CELL RESEARCH. 2011;317(1):70-81Dynamic changes in connexin expression following engraftment of neural stem cells to striatal tissueJaderstad J; Jaderstad LM; Herlenius E
- Article: NEUROREPORT. 2010;21(17):1126-1132Jaderstad J; Brismar H; Herlenius E
- Article: REGENERATIVE MEDICINE. 2010;5(6):901-917Jaderstad LM; Jaderstad J; Herlenius E
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(11):5184-5189Jaderstad J; Jaderstad LM; Li J; Chintawar S; Salto C; Pandolfo M; Ourednik V; Teng YD; Sidman RL; Arenas E; Snyder EY; Herlenius E
- Article: JOURNAL OF PEDIATRICS. 2010;156(3):382-U73Davis PG; Schmidt B; Roberts RS; Doyle LW; Asztalos E; Haslam R; Sinha S; Tin W
- Article: ACTA PAEDIATRICA. 2008;97(3):285-292Hofstetter AO; Legnevall L; Herlenius E; Katz-Salamon M
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2007;357(19):1893-1902Schmidt B; Roberts RS; Davis P; Doyle LW; Barrington KJ; Ohlsson A; Solimano A; Tin W
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(23):9894-9899Hofstetter AO; Saha S; Siljehav V; Jakobsson P-J; Herlenius E
- Article: EPILEPSIA. 2007;48(6):1138-1142Herlenius E; Heron SE; Grinton BE; Keay D; Scheffer IE; Mulley JC; Berkovic SF
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(20):2112-2121Schmidt B; Roberts RS; Davis P; Doyle LW; Barrington KJ; Ohlsson A; Solimano A; Tin W
- Article: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2005;146(2-3):135-146Hofstetter AO; Herlenius E
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(1):11-17Salomonsson S; Sonesson SE; Ottosson L; Muhallab S; Olsson T; Sunnerhagen M; Kuchroo VK; Thorén P; Herlenius E; Wahren-Herlenius M
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2004;556(1):43-59Nsegbe E; Wallen-Mackenzie Å; Dauger S; Roux JC; Shvarev Y; Lagercrantz H; Perlmann T; Herlenius E
- Article: PEDIATRIC RESEARCH. 2003;54(3):326-331Olsson A; Kayhan G; Lagercrantz H; Herlenius E
- Article: PEDIATRIC RESEARCH. 2002;51(1):4-12Herlenius E; Ådén U; Tang LQ; Lagercrantz H
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(16):9407-9412Johansson B; Halldner L; Dunwiddie TV; Masino SA; Poelchen W; Giménez-Llort L; Escorihuela RM; Fernández-Teruel A; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Betsholtz C; Herlenius E; Fredholm BB
- Article: BRAIN RESEARCH. 2000;884(1-2):201-205Takita K; Herlenius E; Yamamoto Y; Lindahl SGE
- Article: PEDIATRIC RESEARCH. 2000;48(2):177-183Ådén U; Herlenius E; Tang LQ; Fredholm BB
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 1999;518(1):159-172Herlenius E; Lagercrantz H
- Journal article: ANESTHESIOLOGY. 1998;89(Supplement):1358aTHE INTERACTION BETWEEN MORPHINE AND SOME NEUROACTIVE SUBSTANCES IN THE MEDULLARY RESPIRATION CENTERTakita K; Herlenius E; Lindahl SGE; Yamamoto Y
- Journal article: PEDIATRIC RESEARCH. 1998;44(3):456Herlenius E; Lagercrantz H
- Journal article: PEDIATRIC RESEARCH. 1998;44(3):456Herlenius E; Kayhan G; Lagercrantz H
- Article: BRAIN RESEARCH. 1998;800(2):308-311Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
- Journal article: ANESTHESIA AND ANALGESIA. 1998;86(2S):513s.-513STakita K; Herlenius E; Lindahl SGE; Yamamoto Y
- Article: BRAIN RESEARCH. 1997;778(1):233-241Takita K; Herlenius EAP; Lindahl SGE; Yamamoto Y
- Article: PEDIATRIC RESEARCH. 1997;42(1):46-53Herlenius E; Lagercrantz H; Yamamoto Y
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All other publications
- Preprint: HTTPS://BIOETHICSOPENRESEARCH.ORG/ARTICLES/2-3/V1. 2024Herlenius E; Lidströmer N
- Preprint: RESEARCH SQUARE. 2024Lidströmer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
- Preprint: RESEARCH SQUARE PLATFORM LLC. 2024Davids J; ElSharkawy M; Ashrafian H; Herlenius E; Lidströmer N
- Preprint: RESEARCH SQUARE. 2024Davids J; ElSharkawy M; Ashrafian H; Herlenius E; Lidströmer N
- Preprint: RESEARCH SQUARE. 2024Lidströmer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
- Preprint: RESEARCH SQUARE. 2024Lidströmer N; Davids J; ElSharkawy M; Herlenius E; Ashrafian H
- Book chapter: MACHINE LEARNING APPLICATIONS IN MEDICINE AND BIOLOGY. 2024;p. 115-149Honoré A; Siren H; Vinuesa R; Chatterjee S; Herlenius E
- Review: JOURNAL OF PHYSIOLOGY-LONDON. 2023;601(21):4667-4689Ahmadzadeh E; Polglase GR; Stojanovska V; Herlenius E; Walker DW; Miller SL; Allison BJ
- Preprint: RESEARCH SQUARE. 2023Lidströmer N; Davids J; ElSharkawy M; Herlenius E; Ashrafian H
- Preprint: RESEARCH SQUARE. 2023Lidströmer N; Davids J; ElSharkawy M; Herlenius E; Ashrafian H
- Conference publication: 2022;00:1-6Honoré A; Siren H; Vinuesa R; Chatterjee S; Herlenius E
- Review: ISCIENCE. 2022;25(5):104295Samara A; Khalil A; O'Brien P; Herlenius E
- Preprint: INSTITUTE OF ELECTRICAL AND ELECTRONICS ENGINEERS (IEEE). 2022Honoré A; Forsberg D; jost K; Adolphson K; Stålhammar A; Herlenius E; Chatterjee S
- Preprint: INSTITUTE OF ELECTRICAL AND ELECTRONICS ENGINEERS (IEEE). 2022Honoré A; Forsberg D; jost K; Adolphson K; Stålhammar A; Herlenius E; Chatterjee S
- Editorial comment: CELL REPORTS MEDICINE. 2022;3(1):100490Samara A; Herlenius E; Brien PO; Khalil A
- Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2022;p. 1047-1056Forsberg D; Honoré A; Jost K; Persad E; Coste K; Chatterjee S; Rautiainen S; Herlenius E
- Book chapter: ARTIFICIAL INTELLIGENCE IN COVID-19. 2022;p. 257-277Danker C; Murzabekov M; Forsberg D; Lidströmer N; Honoré A; Rautiainen S; Herlenius E
- Review: ACTA PAEDIATRICA. 2021;110(12):3201-3226Persad E; Jost K; Honore A; Forsberg D; Coste K; Olsson H; Rautiainen S; Herlenius E
- Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):22Stalhammar AM; Adolphson K; Honore A; Forsberg D; Herlenius E; Jost K
- Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):22Adolphson K; Honore A; Forsberg D; Stalhammar AM; Jost K; Herlenius E
- Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):13-14Clareus A; Honore A; Koch G; Herlenius E; Jost K
- Editorial comment: ACTA PAEDIATRICA. 2021;110(9):2578-2580Sterky E; Olsson-Akefeldt S; Hertting O; Herlenius E; Alfven T; Ryd Rinder M; Rhedin S; Hildenwall H
- Conference publication: FASEB JOURNAL. 2021;35Reising J; Phillips W; Herlenius E
- Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2021;p. 1-10Forsberg D; Honoré A; Jost K; Persad E; Coste K; Chatterjee S; Rautiainen S; Herlenius E
- Letter: ACTA PAEDIATRICA. 2020;109(10):2152-2154Hildenwall H; Luthander J; Rhedin S; Hertting O; Olsson-Akefeldt S; Erik M; Alfven T; Herlenius E; Ryd Rinder M
- Conference publication: 2020;00:1130-1134Honoré A; Liu D; Forsberg D; Coste K; Herlenius E; Chatterjee S; Skoglund M
- Preprint: BIORXIV. 2019Becker M; Mastropasqua F; Reising JP; Maier S; Ho M-L; Rabkina I; Li D; Neufeld J; Ballenberger L; Myers L; Moritz V; Kele M; Wincent J; Willfors C; Sitnikov R; Herlenius E; Anderlid B-M; Falk A; Bölte S; Tammimies K
- Preprint: ARXIV. 2019Honore A; Liu D; Forsberg D; Coste K; Herlenius E; Chatterjee S; Skoglund M
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1423Becker M; Mastropasqua F; Reising JP; Rabkina I; Ballenberger L; Kele M; Willfors C; Herlenius E; Bolte S; Anderlid BM; Falk A; Tammimies K
- Published conference paper: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2019;265:3-8Forsberg D; Herlenius E
- Letter: JAMA PEDIATRICS. 2019;173(5):487-489Schmidt B; Anderson PJ; Asztalos EV; Doyle L; Grunau RE; Moddemann D; Roberts RS
- Preprint: ARXIV. 2017Honoré A; Siljehav V; Chatterjee S; Herlenius E
- Conference publication: CANCER RESEARCH. 2017;77:5832Dyberg CH; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Forsberg D; Herlenius E; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
- Preprint: BIORXIV. 2017Forsberg D; Ringstedt T; Herlenius E
- Review: CANCER CAUSES & CONTROL. 2017;28(6):599-624Karalexi MA; Dessypris N; Skalkidou A; Biniaris-Georgallis S-I; Kalogirou EI; Thomopoulos TP; Herlenius E; Spector LG; Loutradis D; Chrousos GP; Petridou ET
- Editorial comment: ACTA PAEDIATRICA. 2017;106(2):191-193Herlenius E
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Dzikaite-Ottosson V; Ding B; Strandberg L; Biavati L; Ramskold D; Forsberg D; Bergin L; Ruhrmann S; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
- Meeting abstract: PEDIATRIC RESEARCH. 2011;70:24Schmidt B; Anderson P; Doyle L; Dewey D; Grunau R; Asztalos E; Davis P; Tin W; Moddemann D; Solimano A; Ohlsson A; Barrington K; Roberts R
- Review: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2011;178(3):449-457Herlenius E
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):349-350Dzikaite V; Ambrosi A; Park J; Ottosson L; Sonesson S-E; Kuchroo VK; Herlenius E; Wahren-Herlenius M
- Conference publication: ACTA PAEDIATRICA. 2010;99:19Herlenius E
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):274Herlenius E; Park J; Ambrosi A; Dzikate V; Strandberg L; Kuchroo V; Wahren-Herlenius M
- Published conference paper: EUROPEAN JOURNAL OF NEUROSCIENCE. 2010;31(12):2142-2155Horn Z; Ringstedt T; Blaesse P; Kaila K; Herlenius E
- Book chapter: THE NEWBORN BRAIN. 2010;p. 99-120Herlenius E; Lagercrantz H
- Conference publication: CELL TRANSPLANTATION. 2010;19(3):344Jaderstad J; Jaderstad LM; Li J; Chintawar S; Salto C; Pandolfo M; Ourednik V; Teng YD; Sidman RL; Arenas E; Snyder EY; Herlenius E
- Conference publication: EPILEPSIA. 2007;48:127Heron S; Grinton B; Herlenius E; Keay D; Kron K; Mulley J; Scheffer I; Berkovic S
- Meeting abstract: EXPERIMENTAL NEUROLOGY. 2006;198(2):572Jäderstad J; Danielsson LM; Ourednik V; Snyder EY; Herlenius E
- Conference publication: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2006;79(1-2):156Saha S; Engström L; Mackerlova L; Hofstetter AO; Hebert H; Herlenius E; Blomqvist A; Jakobsson PJ
- Review: EXPERIMENTAL NEUROLOGY. 2004;190:S8-21Herlenius E; Lagercrantz H
- Meeting abstract: PEDIATRIC RESEARCH. 2004;56(3):482Hofstetter AO; Saha S; Lagercrantz H; Jakobsson PJ; Herlenius E
- Conference publication: PEDIATRIC RESEARCH. 2004;55(4):511AHofstetter AO; Saba S; Lagercrantz H; Jakobsson PJ; Herlenius E
- Conference publication: PEDIATRIC RESEARCH. 2003;54(4):594Jäderstad J; Ourednik V; Snyder EY; Herlenius E
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S64Salomonsson S; Ottosson L; RAats J; Herlenius E; Wahren-Herlenius M
- Published conference paper: DRUG DEVELOPMENT RESEARCH. 2003;58(4):350-353Fredholm BB; Halldner L; Johansson C; Schulte G; Lövdahl C; Thorén P; Dunwiddie TV; Masino SA; Poelchen W; Diao LH; Illes P; Zahniser NR; Valen G; Tokuno S; Sommerschild H; Giménez-Llort L; Fernández-Teruel A; Escorihuela RM; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Herlenius E; Pekny S; Gebré-Medhin S; Brown R; Ollerstam A; Persson AEG; Skott O; Johansson B
- Conference publication: EXPERIMENTAL NEUROLOGY. 2002;175(2):418Ourednik V; Ourednik J; Herlenius E; Zou Z; Snyder EY
- Review: EARLY HUMAN DEVELOPMENT. 2001;65(1):21-37Herlenius E; Lagercrantz H
- Conference publication: JOURNAL OF PHYSIOLOGY-LONDON. 2001;533:10SHerlenius E
- Conference publication: PEDIATRIC RESEARCH. 2000;47(4):70AHerlenius E; Aden U; Tang LO; Lagercrantz H
- Doctoral thesis: 1998Herlenius E
- Conference publication: ANESTHESIOLOGY. 1998;89(3A):U1037Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
- Conference publication: ANESTHESIA AND ANALGESIA. 1998;86(2S)Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
- Meeting abstract: ANESTHESIOLOGY. 1997;87(3):A1074Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
- Preprint: SSRN ELECTRONIC JOURNAL.Reising J; Sanchez ACG; Samara A; Herlenius E
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Grants
- Swedish Research Council1 January 2024 - 31 December 2027Immature cardiorespiratory control in infants may result in apneas, sudden unexpected postnatal collapse (SUPC), secondary hypoxic brain damage and SIDS. We have shown that prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response. This has led us to focus on the role of inflammation and brainstem modulation in both clinical and mechanistic studies. These are used to define mechanisms for factors disturbing the physiological and neural pathways that control breathing. main goals are:1) Develop better clinical guidelines and best practices for respiratory failures in newborns e.g. Sudden Unexpected Postnatal Collapse (SUPC).2) To clinically characterize how dysregulation of respiratory control induces life-threatening apneas and if subtle alterations in cardiorespiratory parameters may act as early warning scores for infection, inflammation and a need for increased intervention. Patients recruited at the Pediatric wards and with the help of KTH expertise we use Deep Machine Learning based analysis to develop rapid semiautomatic Novel Early Warning Systems3) To define the pathophysiological mechanism of apneas and involvement of inflammation in the development and activity of brainstem respiration-related neural circuits. In vivo and novel in vitro experimental mouse models and single cell transcriptomics techniques are used.The overall aim is to develop diagnostics and therapeutic approaches against life threatening apneas and collapse.
- Swedish Research Council1 January 2023 - 31 December 2026The primary aim of this research is to determine whether supplementation with probiotics during the first weeks of life reduces the risk of necrotizing enterocolitis (NEC) and neonatal mortality and is safe to use among extremely preterm (EPT) infants born before gestational week 28.P: The study population include EPT infants (n= 1620) born at six tertiary neonatal units in Sweden and four units in Denmark.I: This is a double-blinded multicenter randomized controlled trial where infants in the intervention group will as soon as they tolerate 3 mL breastmilk per feed receive a probiotic combination of Bifidobacterium infantis, Bifidobacterium lactis, and Streptococcus thermophilus diluted in 3 mL breastmilk and given daily until gestational week 34.C: The control group will receive 3 mL breastmilk without probiotic supplementation (blinded) daily.O: Primary outcome variables is a composite endpoint of incidence of NEC and mortality. Secondary outcomes include incidence of sepsis, duration of hospital stay, use of antibiotics, feeding tolerance, growth, and body composition after hospital discharge.Patient benefit: To provide evidence on the usage of probiotics among EPT infants that are not currently covered by clinical recommendations. As EPT infants have the highest risk for NEC and mortality our results have the potential to change current recommendations and improve patient outcomes, decrease mortality, shorten hospitalization, and decrease overall health-care costs.
- Swedish Research Council1 January 2020 - 31 December 2023
- APNEA and INSPIRATIONSCREEN, DETECT AND PROTECT AGAINST INFLAMMATION INDUCED LIFE-THREATENING EVENTSSwedish Heart-Lung Foundation1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2017 - 31 December 2019
- VINNOVA6 December 2010 - 30 November 2014
- Swedish Research Council1 January 2010 - 31 December 2012
- Swedish Research Council1 January 2009 - 31 December 2014
- Swedish Research Council1 January 2009 - 31 December 2014
- Swedish Research Council1 January 2009 - 31 December 2014
Employments
- Professor/Senior Physician, Department of Women's and Children's Health, Karolinska Institutet, 2013-
Degrees and Education
- Docent, Karolinska institutet, 2008
- Captain, Officer in the Swedish Marines, Sjökrigskolan, Swedish Armed Forces, 2004
- Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 1998
- University Medical Degree, Karolinska Institutet, 1994
Leadership and responsibility assignments
- Head of division, Clinical pediatrics, Department of Women's and Children's Health, Karolinska Institutet, 2024-