Eleni Aklillu

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2024;90(11):2823-2836
CYP2B6 and ABCB1 genotypes predict methadone plasma exposure among patients on maintenance therapy against opioid addictions in Tanzania
Mugusi S; Mnkugwe RH; Sanga AA; Salahuddin A; Barclay V; Shayo G; Dahl M-L; Aklillu E
Article: BMC INFECTIOUS DISEASES. 2024;24(1):901
The safety of a dolutegravir (DTG)-based antiretroviral treatment (ART) regimen for pregnancy and birth outcomes in Ethiopia: evidence from multicenter cohort study
Gedefaw A; Tadesse BT; Berhan Y; Makonnen E; Vella S; Aklillu E
Article: DRUG SAFETY. 2024;47(12):1193-1202
Short-Term Training, a Useful Approach for Sustainable Pharmacovigilance Knowledge Development in Tanzania, Kenya, Ethiopia and Rwanda
van Puijenbroek E; Barry A; Khaemba C; Ntirenganya L; Gebreyesus TD; Fimbo A; Minzi O; Makonnen E; Oluka M; Guantai A; Aklillu E
Article: BMC PHARMACOLOGY AND TOXICOLOGY. 2024;25(1):38
Pharmacokinetics of piperaquine and its association with intermittent malaria preventive therapy outcomes during pregnancy
Mlugu EM; Minzi OMS; Johansson M; Kamuhabwa AAR; Aklillu E
Article: INFECTIOUS DISEASES OF POVERTY. 2024;13(1):44
Efficacy of ivermectin and albendazole combination in suppressing transmission of lymphatic filariasis following mass administration in Tanzania: a prospective cohort study
Fimbo AM; Mnkugwe RH; Mlugu EM; Kunambi PP; Malishee A; Minzi OMS; Kamuhabwa AAR; Aklillu E
Article: SCIENTIFIC REPORTS. 2024;14(1):11730
CYP2C19 and CYP2J2 genotypes predict praziquantel plasma exposure among Ethiopian school-aged children
Gebreyesus TD; Makonnen E; Telele NF; Barry A; Mnkugwe RH; Gerba H; Dahl M-L; Aklillu E
Article: INFECTIOUS DISEASES. 2024;56(4):308-319
Variability in plasma rifampicin concentrations and role of SLCO1B1, ABCB1, AADAC2 and CES2 genotypes in Ethiopian patients with tuberculosis
Sileshi T; Makonnen E; Telele NF; Barclay V; Zumla A; Aklillu E
Article: INFECTIOUS DISEASES OF POVERTY. 2024;13(1):8
Reduced efficacy of single-dose albendazole against Ascaris lumbricoides, and Trichuris trichiura, and high reinfection rate after cure among school children in southern Ethiopia: a prospective cohort study
Gebreyesus TD; Makonnen E; Tadele T; Mekete K; Gashaw H; Gerba H; Aklillu E
Article: TROPICAL MEDICINE AND HEALTH. 2023;51(1):72
Efficacy and safety of praziquantel treatment against Schistosoma mansoni infection among pre-school age children in southern Ethiopia
Tadele T; Astatkie A; Tadesse BT; Makonnen E; Aklillu E; Abay SM
Article: CPT: PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY. 2023;12(12):1884-1896
Population pharmacokinetics of ivermectin after mass drug administration in lymphatic filariasis endemic communities of Tanzania
Fimbo AM; Mlugu EM; Kitabi EN; Kulwa GS; Iwodyah MA; Mnkugwe RH; Kunambi PP; Malishee A; Kamuhabwa AAR; Minzi OM; Aklillu E
Article: DRUG SAFETY. 2023;46(10):961-974
Comparative Safety Surveillance of Triple (IDA) Versus Dual Therapy (DA) in Mass Drug Administration for Elimination of Lymphatic Filariasis in Kenya: A Cohort Event Monitoring Study
Khaemba C; Barry A; Omondi WP; Kirui E; Oluka M; Parthasarathi G; Njenga SM; Guantai A; Aklillu E
Article: PATHOGENS. 2023;12(9):1170
Efficacy of Single-Dose Praziquantel for the Treatment of Schistosoma mansoni Infections among School Children in Rwanda
Kabatende J; Ntirenganya L; Mugisha M; Barry A; Ruberanziza E; Bienvenu E; Bergman U; Aklillu E
Article: SCIENTIFIC REPORTS. 2023;13(1):11438
Correlation of N-acetyltransferase 2 genotype and acetylation status with plasma isoniazid concentration and its metabolic ratio in ethiopian tuberculosis patients
Sileshi T; Telele NF; Burkley V; Makonnen E; Aklillu E
Article: PATHOGENS. 2023;12(7):858
Prevalence and Determinants of Schistosoma mansoni Infection among Pre-School Age Children in Southern Ethiopia
Tadele T; Astatkie A; Abay SM; Tadesse BT; Makonnen E; Aklillu E
Article: CPT: PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY. 2023;12(6):783-794
Genetic and non-genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus-1-infected children in Ethiopia
Chala A; Kitabi EN; Ahmed JH; Tadesse BT; Chaka TE; Makonnen E; Aklillu E
Article: SCIENTIFIC REPORTS. 2023;13(1):1446
Effect of pharmacogenetic variations on praziquantel plasma concentration and safety outcomes among school children in Rwanda
Barry A; Kabatende J; Telele NF; Mnkugwe RH; Mugisha M; Ntirenganya L; Bienvenu E; Aklillu E
Article: PHARMACEUTICALS. 2023;16(2):139
Efficacy of Single-Dose Albendazole for the Treatment of Soil-Transmitted Helminthic Infections among School Children in Rwanda-A Prospective Cohort Study
Kabatende J; Barry A; Mugisha M; Ntirenganya L; Bergman U; Bienvenu E; Aklillu E
Article: ETHIOPIAN JOURNAL OF HEALTH DEVELOPMENT. 2023;37(1)
Methicillin Resistant Staphylococcus aureus contamination of Health care worker gowns and Uniforms: A cross-sectional Study from the biggest teaching hospital in Ethiopia
Desta K; Aklillu E; Gebrehiwot Y; Enquoselassie F; Cantillon D; Al-Hassan L; Price JR; Newport MJ; Davey G; Woldeamanuel Y
Article: FRONTIERS IN PHARMACOLOGY. 2023;14:968106
Efficacy and safety of praziquantel preventive chemotherapy in Schistosoma mansoni infected school children in Southern Ethiopia: A prospective cohort study
Gebreyesus TD; Makonnen E; Tadele T; Mekete K; Gashaw H; Gerba H; Aklillu E
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(23):15168
Pregnancy Increases CYP3A Enzymes Activity as Measured by the 4β-Hydroxycholesterol/Cholesterol Ratio
Mlugu EM; Minzi OM; Kamuhabwa AAR; Diczfalusy U; Aklillu E
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2022;124:S69-S74
Blue Skies research is essential for ending the Tuberculosis pandemic and advancing a personalized medicine approach for holistic management of Respiratory Tract infections
Ntoumi F; Petersen E; Mwaba P; Aklillu E; Mfinanga S; Yeboah-Manu D; Maeurer M; Zumla A
Article: JOURNAL OF CLINICAL MEDICINE. 2022;11(21):6300
Safety Surveillance of Mass Praziquantel and Albendazole Co-Administration in School Children from Southern Ethiopia: An Active Cohort Event Monitoring
Gebreyesus TD; Makonnen E; Tadele T; Gashaw H; Degefe W; Gerba H; Tadesse BT; Gurumurthy P; Aklillu E
Article: DRUG SAFETY. 2022;45(8):909-922
Safety of Praziquantel and Albendazole Coadministration for the Control and Elimination of Schistosomiasis and Soil-Transmitted Helminths Among Children in Rwanda: An Active Surveillance Study
Kabatende J; Barry A; Mugisha M; Ntirenganya L; Bergman U; Bienvenu E; Aklillu E
Article: JOURNAL OF PERSONALIZED MEDICINE. 2022;12(7):1087
CYP3A and CYP2B6 Genotype Predicts Glucose Metabolism Disorder among HIV Patients on Long-Term Efavirenz-Based ART: A Case-Control Study
Tadesse WT; Mlugu EM; Shibeshi W; Degu WA; Engidawork E; Aklillu E
Article: SCIENTIFIC REPORTS. 2022;12(1):9698
Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity
Petros Z; Habtewold A; Makonnen E; Aklillu E
Article: PHARMACEUTICALS. 2022;15(5):594
Safety and Tolerability of Ivermectin and Albendazole Mass Drug Administration in Lymphatic Filariasis Endemic Communities of Tanzania: A Cohort Event Monitoring Study
Fimbo AM; Minzi OM; Mmbando BP; Gurumurthy P; Kamuhabwa AAR; Aklillu E
Article: INFECTION AND DRUG RESISTANCE. 2022;15:6839-6852
Population Pharmacokinetics of Levofloxacin and Moxifloxacin, and the Probability of Target Attainment in Ethiopian Patients with Multidrug-Resistant Tuberculosis
Sidamo T; Rao PS; Aklillu E; Shibeshi W; Park Y; Cho Y-S; Shin J-G; Heysell SK; Mpagama SG; Engidawork E
Article: PLOS ONE. 2022;17(1):e0262604
Prevalence and predictors of glucose metabolism disorders among People Living with HIV on combination antiretroviral therapy
Tadesse WT; Adankie BT; Shibeshi W; Amogne W; Aklillu E; Engidawork E
Article: INFECTION AND DRUG RESISTANCE. 2022;15:3135-3147
High Levels of Methicillin-Resistant Staphylococcus aureus Carriage Among Healthcare Workers at a Teaching Hospital in Addis Ababa Ethiopia: First Evidence Using mecA Detection
Desta K; Aklillu E; Gebrehiwot Y; Enquselassie F; Cantillon D; Al-Hassan L; Price JR; Newport MJ; Davey G; Woldeamanuel Y
Article: JOURNAL OF PERSONALIZED MEDICINE. 2021;11(12):1303
Predictors of Efavirenz Plasma Exposure, Auto-Induction Profile, and Effect of Pharmacogenetic Variations among HIV-Infected Children in Ethiopia: A Prospective Cohort Study
Chala A; Tadesse BT; Chaka TE; Mukonzo J; Kitabi EN; Tadesse S; Pohanka A; Makonnen E; Aklillu E
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2021;113(Suppl 1):S7-S12
Global Tuberculosis Report 2020-Reflections on the Global TB burden, treatment and prevention efforts
Chakaya J; Khan M; Ntoumi F; Aklillu E; Fatima R; Mwaba P; Kapata N; Mfinanga S; Hasnain SE; Katoto PDMC; Bulabula ANH; Sam-Agudu NA; Nachega JB; Tiberi S; McHugh TD; Abubakar I; Zumla A
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2021;110(6):1478-1489
Effectiveness of Intermittent Preventive Treatment With Dihydroartemisinin-Piperaqunine Against Malaria in Pregnancy in Tanzania: A Randomized Controlled Trial
Mlugu EM; Minzi O; Kamuhabwa AAR; Aklillu E
Article: SCIENTIFIC REPORTS. 2021;11(1):17955
Optimal single sampling time-point for monitoring of praziquantel exposure in children
Mnkugwe RH; Ngaimisi Kitabi E; Kinung'hi S; Kamuhabwa AAR; Minzi OM; Aklillu E
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3294-3308
Early or deferred initiation of efavirenz during rifampicin-based TB therapy has no significant effect on CYP3A induction in TB-HIV infected patients
Aklillu E; Zumla A; Habtewold A; Amogne W; Makonnen E; Yimer G; Burhenne J; Diczfalusy U
Article: PHARMACEUTICALS. 2021;14(5):400
Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of Schistosoma mansoni Infection
Minzi OM; Mnkugwe RH; Ngaimisi E; Kinung'hi S; Hansson A; Pohanka A; Kamuhabwa A; Aklillu E
Article: PHARMACEUTICALS. 2021;14(3):264
Safety and Tolerability of Mass Diethylcarbamazine and Albendazole Administration for the Elimination of Lymphatic Filariasis in Kenya: An Active Surveillance Study
Khaemba C; Barry A; Omondi WP; Bota K; Matendechero S; Wandera C; Siyoi F; Kirui E; Oluka M; Nambwa P; Gurumurthy P; Njenga SM; Guantai A; Aklillu E
Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2021;18(4):1941
Comparative Assessment of the Pharmacovigilance Systems within the Neglected Tropical Diseases Programs in East Africa-Ethiopia, Kenya, Rwanda, and Tanzania
Barry A; Olsson S; Khaemba C; Kabatende J; Dires T; Fimbo A; Minzi O; Bienvenu E; Makonnen E; Kamuhabwa A; Oluka M; Guantai A; van Puijenbroek E; Bergman U; Nkayamba A; Mugisha M; Gurumurthy P; Aklillu E
Article: BMC MEDICAL EDUCATION. 2021;21(1):36
Understanding the key processes of excellence as a prerequisite to establishing academic centres of excellence in Africa
Fekadu A; Oppenheim C; Manyazewal T; Nislow C; Woldeamanuel Y; Hailu A; Belete A; Wondimagegn D; Hanlon C; Gebremariam T; Collins A; Larson CJ; Gebreyes W; Aklilu E; Muula AS; Mugus S; Caffery C; Giday M; Yimer G; Davey G; Medhin G; Makonnen E
Article: INFECTION AND DRUG RESISTANCE. 2021;14:5473-5489
Explorative Analysis of Treatment Outcomes of Levofloxacin- and Moxifloxacin-Based Regimens and Outcome Predictors in Ethiopian MDR-TB Patients: A Prospective Observational Cohort Study
Sidamo T; Shibeshi W; Yimer G; Aklillu E; Engidawork E
Article: CLINICAL PHARMACOLOGY: ADVANCES AND APPLICATIONS. 2021;13:1-12
The Impact of First-Line Anti-Tubercular Drugs' Pharmacokinetics on Treatment Outcome: A Systematic Review
Sileshi T; Tadesse E; Makonnen E; Aklillu E
Article: FRONTIERS IN PHARMACOLOGY. 2021;12:712084
Effect of Pharmacogenetics Variations on Praziquantel Plasma Concentrations and Schistosomiasis Treatment Outcomes Among Infected School-Aged Children in Tanzania
Mnkugwe RH; Minzi O; Kinung'hi S; Kamuhabwa A; Aklillu E
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2021;40(1):60-65
Predictors of Virologic Failure Among a Cohort of HIV-infected Children in Southern Ethiopia
Tadesse BT; Foster BA; Latour E; Lim JY; Jerene D; Ruff A; Aklillu E
Article: PATHOGENS. 2020;9(12):1076
Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda
Kabatende J; Mugisha M; Ntirenganya L; Barry A; Ruberanziza E; Mbonigaba JB; Bergman U; Bienvenu E; Aklillu E
Article: PATHOGENS. 2020;9(11):E920-920
Prevalence, Intensity, and Correlates of Schistosomiasis and Soil-Transmitted Helminth Infections after Five Rounds of Preventive Chemotherapy among School Children in Southern Ethiopia
Gebreyesus TD; Tadele T; Mekete K; Barry A; Gashaw H; Degefe W; Tadesse BT; Gerba H; Gurumurthy P; Makonnen E; Aklillu E
Article: PLOS NEGLECTED TROPICAL DISEASES. 2020;14(9):e0008619
Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial
Mnkugwe RH; Minzi O; Kinung'hi S; Kamuhabwa A; Aklillu E
Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(5):1550
Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania
Fimbo AM; Minzi OMS; Mmbando BP; Barry A; Nkayamba AF; Mwamwitwa KW; Malishee A; Seth MD; Makunde WH; Gurumurthy P; Lusingu JPA; Kamuhabwa AAR; Aklillu E
Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2020;17(9):E3123-3123
Prevalence and Correlates of Asymptomatic Malaria and Anemia on First Antenatal Care Visit among Pregnant Women in Southeast, Tanzania
Mlugu EM; Minzi O; Kamuhabwa AAR; Aklillu E
Article: MALARIA JOURNAL. 2020;19(1):160
Effect of sulfadoxine-pyrimethamine doses for prevention of malaria during pregnancy in hypoendemic area in Tanzania
Mikomangwa WP; Minzi O; Mutagonda R; Baraka V; Mlugu EM; Aklillu E; Kamuhabwa AAR
Article: DRUG SAFETY. 2020;43(4):339-350
Comparative Assessment of the National Pharmacovigilance Systems in East Africa: Ethiopia, Kenya, Rwanda and Tanzania
Barry A; Olsson S; Minzi O; Bienvenu E; Makonnen E; Kamuhabwa A; Oluka M; Guantai A; Bergman U; van Puijenbroek E; Gurumurthy P; Aklillu E
Article: PATHOGENS. 2020;9(3):E207-207
Effectiveness of Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria and Adverse Birth Outcomes in Pregnant Women
Mlugu EM; Minzi O; Asghar M; Farnert A; Kamuhabwa AAR; Aklillu E
Article: EXPERT REVIEW OF CARDIOVASCULAR THERAPY. 2020;18(3):165-173
Profiles of patients on warfarin anticoagulation therapy in a leading tertiary referral hospital in Kenya; findings and implications for Kenya
Nyamu DG; Guantai AN; Osanjo GO; Godman B; Aklillu E
Article: MALARIA JOURNAL. 2020;19(1):66
Usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with artemether-lumefantrine in Tanzania
Kilonzi M; Minzi O; Mutagonda R; Baraka V; Sasi P; Aklillu E; Kamuhabwa A
Article: TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE. 2020;114(2):107-114
Role of pharmacogenetics in rifampicin pharmacokinetics and the potential effect on TB-rifampicin sensitivity among Ugandan patients
Mukonzo JK; Kengo A; Kutesa B; Nanzigu S; Pohanka A; McHugh TD; Zumla A; Aklillu E
Article: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY. 2020;21(1):29-52
Cigarette smoking and heavy coffee consumption affecting response to olanzapine: The role of genetic polymorphism
Djordjevic N; Radmanovic B; Cukic J; Baskic D; Djukic-Dejanovic S; Milovanovic D; Aklillu E
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:406
Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients
Ahmed JH; Makonnen E; Bisaso RK; Mukonzo JK; Fotoohi A; Aseffa A; Howe R; Hassan M; Aklillu E
Article: PLOS ONE. 2020;15(2):e0228770
Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania
Mnkugwe RH; Minzi OS; Kinung'hi SM; Kamuhabwa AA; Aklillu E
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:26
Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations
Mugusi S; Habtewold A; Ngaimisi E; Amogne W; Yimer G; Minzi O; Makonnen E; Sudfeld C; Burhenne J; Aklillu E
Article: PATHOGENS. 2019;9(1):E28-28
Efficacy and Safety of Praziquantel for Treatment of Schistosoma mansoni Infection among School Children in Tanzania
Mnkugwe RH; Minzi OS; Kinung'hi SM; Kamuhabwa AA; Aklillu E
Article: DRUG METABOLISM AND DISPOSITION. 2019;47(12):1415-1424
Pregnancy and CYP3A5 Genotype Affect Day 7 Plasma Lumefantrine Concentrations
Mutagonda RF; Minzi OMS; Massawe SN; Asghar M; Farnert A; Kamuhabwa AAR; Aklillu E
Journal article: PHARMACOGENETICS AND GENOMICS. 2019;29(9):224
PharmGKB summary: very important pharmacogene information for CYP1A2 (vol 22, pg 73, 2012)
Thorn CF; Aklillu E; Klein TE; Altman RB
Article: PATHOGENS. 2019;8(4):E161-161
Rates and Correlates of Short Term Virologic Response among Treatment-Naive HIV-Infected Children Initiating Antiretroviral Therapy in Ethiopia: A Multi-Center Prospective Cohort Study
Tadesse BT; Chala A; Mukonzo J; Chaka TE; Tadesse S; Makonnen E; Brumme ZL; Brumme CJ; Aklillu E
Article: VIRUSES. 2019;11(9):E877-877
Prevalence and Correlates of Pre-Treatment HIV Drug Resistance among HIV-Infected Children in Ethiopia
Tadesse BT; Tsai O; Chala A; Chaka TE; Eromo T; Lapointe HR; Baraki B; Shahid A; Tadesse S; Makonnen E; Brumme ZL; Aklillu E; Brumme CJ
Article: CANCERS. 2019;11(9):E1353-1353
CYP2D6 Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients
Ahmed JH; Makonnen E; Fotoohi A; Aseffa A; Howe R; Aklillu E
Article: BMC PREGNANCY AND CHILDBIRTH. 2019;19(1):236
Adverse birth outcomes among mothers who received intermittent preventive treatment with Sulphadoxine-Pyrimethamine in the low malaria transmission region
Mikomangwa WP; Minzi OMS; Aklillu E; Kamuhabwa AAR
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2019;83:98-101
Potential drug-drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
Mukonzo J; Aklillu E; Marconi V; Schinazi RF
Article: MALARIA JOURNAL. 2019;18(1):133
Comparison of malaria treatment outcome of generic and innovator's anti-malarial drugs containing artemether-lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children
Kilonzi M; Minzi O; Mutagonda R; Sasi P; Kamuhabwa A; Aklillu E
Article: JOURNAL OF CLINICAL MEDICINE. 2019;8(4):E430-430
HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
Tadesse BT; Foster BA; Chala A; Chaka TE; Bizuayehu T; Ayalew F; Meskel GH; Tadesse S; Jerene D; Makonnen E; Aklillu E
Article: HIV MEDICINE. 2019;20(2):147-156
Hepatic and renal toxicity and associated factors among HIV-infected children on antiretroviral therapy: a prospective cohort study
Tadesse BT; Foster BA; Kabeta A; Ayalew F; Meskel GH; Jerene D; Makonnen E; Aklillu E
Article: NUTRIENTS. 2019;11(2):E289-289
Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia
Ahmed JH; Makonnen E; Fotoohi A; Yimer G; Seifu D; Assefa M; Tigeneh W; Aseffa A; Howe R; Aklillu E
Article: AAS OPEN RESEARCH. 2019;2:19
African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa.
Dandara C; Masimirembwa C; Haffani YZ; Ogutu B; Mabuka J; Aklillu E; Bolaji O; H3Africa
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:481
CYP2J2*7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients
Ahmed JH; Makonnen E; Yimer G; Seifu D; Bekele A; Assefa M; Aseffa A; Howes R; Fotoohi A; Hassan M; Aklillu E
Journal article: 2018
Rifampicin-Efavirenz Drug Interactions and Cytochrome P450 3A (CYP3A) Enzyme Induction in Patients with Tuberculosis and HIV Co-Infection - A Prospective Cohort Study
Aklillu E; Zumla A; Habtewold A; Amogne W; Makonnen E; Yimer G; Nylé n H; Bertilsson L; Burhenne JUR; Diczfalusy U
Article: SCIENTIFIC REPORTS. 2018;8(1):16316
Long-term efavirenz pharmacokinetics is comparable between Tanzanian HIV and HIV/Tuberculosis patients with the same CYP2B6*6 genotype
Kitabi EN; Minzi OMS; Mugusi S; Sasi P; Janabi M; Mugusi F; Bertilsson L; Burhenne J; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2018;74(11):1405-1415
Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin
Mugusi S; Ngaimisi E; Janabi M; Mugusi F; Minzi O; Aris E; Bakari M; Bertilsson L; Burhenne J; Sandstrom E; Aklillu E
Article: SCIENTIFIC REPORTS. 2018;8(1):12726
Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations
Bedada W; de Andres F; Engidawork E; Hussein J; LLerena A; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2018;74(7):903-911
N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians
Aklillu E; Antonio Carrillo J; Makonnen E; Bertilsson L; Djordjevic N
Article: VIRUSES. 2018;10(2):E60-60
High Levels of Dual-Class Drug Resistance in HIV-Infected Children Failing First-Line Antiretroviral Therapy in Southern Ethiopia
Tadesse BT; Kinloch NN; Baraki B; Lapointe HR; Cobarrubias KD; Brockman MA; Brumme CJ; Foster BA; Jerene D; Makonnen E; Aklillu E; Brumme ZL
Journal article: PROCEEDINGS FOR ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY. 2018;WCP2018(0):sy48-sy42
African Pharmacogenomics Research Consortium: Focus on HIV, Tuberculosis and Malaria treatment
Aklillu E
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2017;61(8):e00207-e00217
Population Pharmacokinetic Model Linking Plasma and Peripheral Blood Mononuclear Cell Concentrations of Efavirenz and Its Metabolite, 8-Hydroxy-Efavirenz, in HIV Patients
Habtewold A; Aklillu E; Makonnen E; Yimer G; Bertilsson L; Burhenne J; Owen JS
Article: MALARIA JOURNAL. 2017;16(1):267
Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women
Mutagonda RF; Kamuhabwa AAR; Minzi OMS; Massawe SN; Asghar M; Homann MV; Farnert A; Aklillu E
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2017;21(4):207-216
Genome-Wide Association and Replication Study of Hepatotoxicity Induced by Antiretrovirals Alone or with Concomitant Anti-Tuberculosis Drugs
Petros Z; Lee MTM; Takahashi A; Zhang Y; Yimer G; Habtewold A; Schuppe-Koistinen I; Mushiroda T; Makonnen E; Kubo M; Aklillu E
Journal article: BMJ GLOBAL HEALTH. 2017;2(Suppl 2):a39
CYP2B6 GENOTYPE BASED EFAVIRENZ DOSE RECOMMENDATIONS DURING RIFAMPICIN-BASED ANTITUBERCULOSIS CO-TREATMENT FOR A SUB-SAHARAN AFRICA POPULATION
Mukonzo J; Kuteesa R; Ogwal-Okeng J; Gustafsson LL; Owen J; Aklillu E
Journal article: BMJ GLOBAL HEALTH. 2017;2(Suppl 2):a11
PREVALENCE AND RISK FACTORS FOR EFAVIRENZ-BASED ANTIRETROVIRAL TREATMENT-ASSOCIATED SEVERE VITAMIN D DEFICIENCY: A PROSPECTIVE COHORT STUDY
Nylén H; Habtewold A; Makonnen E; Yimer G; Burhenne J; Diczfalusy U; Aklillu E
Journal article: BMJ GLOBAL HEALTH. 2017;2(Suppl 2):a1-a72
Abstracts of the Eighth EDCTP Forum, 6-9 November 2016.
Article: FRONTIERS IN PHARMACOLOGY. 2017;8:90
HLA-B*57 Allele Is Associated with Concomitant Anti-tuberculosis and Antiretroviral Drugs Induced Liver Toxicity in Ethiopians
Petros Z; Kishikawa J; Makonnen E; Yimer G; Habtewold A; Aklillu E
Article: LIVER INTERNATIONAL. 2017;37(1):132-140
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury
Mikus M; Drobin K; Gry M; Bachmann J; Lindberg J; Yimer G; Aklillu E; Makonnen E; Aderaye G; Roach J; Fier I; Kampf C; Goepfert J; Perazzo H; Poynard T; Stephens C; Andrade RJ; Isabel Lucena M; Arber N; Uhlen M; Watkins PB; Schwenk JM; Nilsson P; Schuppe-Koistinen I
Article: JOURNAL OF CLINICAL PHARMACOLOGY. 2016;56(12):1538-1549
Long-Term Effect of Rifampicin-Based Anti-TB Regimen Coadministration on the Pharmacokinetic Parameters of Efavirenz and 8-Hydroxy-Efavirenz in Ethiopian Patients
Habtewold A; Aklillu E; Makonnen E; Amogne W; Yimer G; Aderaye G; Bertilsson L; Owen JS; Burhenne J
Article: BMC GENOMICS. 2016;17(1):755
Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity
Petros Z; Lee M-TM; Takahashi A; Zhang Y; Yimer G; Habtewold A; Amogne W; Aderaye G; Schuppe-Koistinen I; Mushiroda T; Makonnen E; Kubo M; Aklillu E
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2016;20(9):538-545
SLCO1B1 Gene Variations Among Tanzanians, Ethiopians, and Europeans: Relevance for African and Worldwide Precision Medicine
Aklillu E; Habtewold A; Ngaimisi E; Yimer G; Mugusi S; Amogne W; Reuter T; Meid A; Hoffmann MM; Weiss J
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2016;20(9):496-497
Conference Report: First Pharmacogenetics and Precision Medicine Conference in Africa (April 7-9, 2016, Cape Town, South Africa)
Dandara C; Suarez-Kurtz G; Aklillu E
Article: MEDICINE (UNITED KINGDOM). 2016;95(34):e4631
Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study
Nylen H; Habtewold A; Makonnen E; Yimer G; Bertilsson L; Burhenne J; Diczfalusy U; Aklillu E
Article: MALARIA JOURNAL. 2016;15(1):278
Malaria prevalence, severity and treatment outcome in relation to day 7 lumefantrine plasma concentration in pregnant women
Mutagonda RF; Kamuhabwa AAR; Minzi OMS; Massawe SN; Maganda BA; Aklillu E
Article: PHARMACOGENOMICS. 2016;17(6):603-613
CYP2B6 genotype-based efavirenz dose recommendations during rifampicin-based antituberculosis cotreatment for a sub-Saharan Africa population
Mukonzo JK; Bisaso RK; Ogwal-Okeng J; Gustafsson LL; Owen JS; Aklillu E
Article: PHARMACOGENOMICS JOURNAL. 2016;16(1):88-95
CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients
Maganda BA; Minzi OMS; Ngaimisi E; Kamuhabwa AAR; Aklillu E
Article: PLOS ONE. 2016;11(8):e0161685
High Gastrointestinal Colonization Rate with Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Hospitalized Patients: Emergence of Carbapenemase-Producing K. pneumoniae in Ethiopia
Desta K; Woldeamanuel Y; Azazh A; Mohammod H; Desalegn D; Shimelis D; Gulilat D; Lamisso B; Makonnen E; Worku A; Mannerqvist K; Struwe J; Aspevall O; Aklillu E
Article: PHARMACOLOGY RESEARCH & PERSPECTIVES. 2015;3(6):e00192
miRNA-27b levels are associated with CYP3A activity in vitro and in vivo.
Ekström L; Skilving I; Ovesjö M-L; Aklillu E; Nylén H; Rane A; Diczfalusy U; Björkhem-Bergman L
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2015;35(6):694-699
The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans
Bedada W; de Andres F; Engidawork E; Pohanka A; Beck O; Bertilsson L; Llerena A; Aklillu E
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2015;19(12):777-781
P450 (Cytochrome) Oxidoreductase Gene (POR) Common Variant (POR*28) Significantly Alters CYP2C9 Activity in Swedish, But Not in Korean Healthy Subjects
Hatta FHM; Aklillu E
Article: DRUG METABOLISM AND DISPOSITION. 2015;43(8):1226-1235
The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19^☆35 and CYP2C19^☆2 Alleles
Chaudhry AS; Prasad B; Shirasaka Y; Fohner A; Finkelstein D; Fan Y; Wang S; Wu G; Aklillu E; Sim SC; Thummel KE; Schuetz EG
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2015;19(6):346-353
Differences in CYP2C9 Genotype and Enzyme Activity Between Swedes and Koreans of Relevance for Personalized Medicine: Role of Ethnicity, Genotype, Smoking, Age, and Sex
Hatta FHM; Lundblad M; Ramsjo M; Kang J-H; Roh H-K; Bertilsson L; Eliasson E; Aklillu E
Article: MALARIA JOURNAL. 2015;14:179
The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment
Maganda BA; Ngaimisi E; Kamuhabwa AAR; Aklillu E; Minzi OMS
Article: PLOS ONE. 2015;10(5):e0122587
Efficacy and Safety of Antiretroviral Therapy Initiated One Week after Tuberculosis Therapy in Patients with CD4 Counts < 200 Cells/μL: TB-HAART Study, a Randomized Clinical Trial
Amogne W; Aderaye G; Habtewold A; Yimer G; Makonnen E; Worku A; Sonnerborg A; Aklillu E; Lindquist L
Article: PHARMACOGENOMICS. 2015;16(10):1047-1064
Is there a need to increase the dose of efavirenz during concomitant rifampicin-based antituberculosis therapy in sub-Saharan Africa? The HIV-TB pharmagene study
Habtewold A; Makonnen E; Amogne W; Yimer G; Aderaye G; Bertilsson L; Burhenne J; Aklillu E
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2014;69(12):3311-3319
Pharmacokinetic and pharmacogenomic modelling of the CYP3A activity marker 4β-hydroxycholesterol during efavirenz treatment and efavirenz/rifampicin co-treatment
Ngaimisi E; Minzi O; Mugusi S; Sasi P; Riedel K-D; Suda A; Ueda N; Bakari M; Janabi M; Mugusi F; Bertilsson L; Burhenne J; Aklillu E; Diczfalusy U
Article: PHARMACOGENOMICS. 2014;15(11):1423-1435
CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efavirenz plasma exposure
Mukonzo JK; Nanzigu S; Waako P; Ogwal-Okeng J; Gustafson LL; Aklillu E
Article: PHARMACOGENETICS AND GENOMICS. 2014;24(8):409-425
PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2
McDonagh EM; Boukouvala S; Aklillu E; Hein DW; Altman RB; Klein TE
Article: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2014;18(7):446-453
High CYP2A6 Enzyme Activity as Measured by a Caffeine Test and Unique Distribution of CYP2A6 Variant Alleles in Ethiopian Population
Aklillu E; Djordjevic N; Carrillo JA; Makonnen E; Bertilsson L; Ingelman-Sundberg M
Article: JOURNAL OF APPLIED GENETICS. 2014;55(2):163-171
The VKORC1 Asp36Tyr variant and VKORC1 haplotype diversity in Ashkenazi and Ethiopian populations
Sominsky S; Korostishevsky M; Kurnik D; Aklillu E; Cohen Y; Ken-Dror G; Loebstein R; Halkin H; Gak E
Article: LIVER INTERNATIONAL. 2014;34(3):367-378
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts
Thulin P; Nordahl G; Gry M; Yimer G; Aklillu E; Makonnen E; Aderaye G; Lindquist L; Mattsson CM; Ekblom B; Antoine DJ; Park BK; Linder S; Harrill AH; Watkins PB; Glinghammar B; Schuppe-Koistinen I
Article: PLOS ONE. 2014;9(4):e94271
Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients
Yimer G; Gry M; Amogne W; Makonnen E; Habtewold A; Petros Z; Aderaye G; Schuppe-Koistinen I; Lindquist L; Aklillu E
Article: PLOS ONE. 2014;9(1):e86919
Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes
Mukonzo JK; Owen JS; Ogwal-Okeng J; Kuteesa RB; Nanzigu S; Sewankambo N; Thabane L; Gustafsson LL; Ross C; Aklillu E
Article: PHARMACOGENOMICS JOURNAL. 2013;13(6):484-489
Pharmacogenetic and pharmacokinetic aspects of CYP3A induction by efavirenz in HIV patients
Habtewold A; Amogne W; Makonnen E; Yimer G; Nylen H; Riedel K-D; Aderaye G; Bertilsson L; Burhenne J; Diczfalusy U; Aklillu E
Article: BMC INFECTIOUS DISEASES. 2013;13:536
CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans
Aklillu E; Odenthal-Hesse L; Bowdrey J; Habtewold A; Ngaimisi E; Yimer G; Amogne W; Mugusi S; Minzi O; Makonnen E; Janabi M; Mugusi F; Aderaye G; Hardwick R; Fu B; Viskaduraki M; Yang F; Hollox EJ
Article: BMC INFECTIOUS DISEASES. 2013;13:261
Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study
Mukonzo JK; Okwera A; Nakasujja N; Luzze H; Sebuwufu D; Ogwal-Okeng J; Waako P; Gustafsson LL; Aklillu E
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2013;54(2):124-132
Haplotypes in the 5′-untranslated region of the CYP1A2gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism
Gervasini G; Ghotbi R; Aklillu E; San Jose C; Cabanillas A; Kishikawa J; Benitez J; Antonio Carrillo J
Article: PLOS ONE. 2013;8(11):e78165
Copy Number Variation of Fc Gamma Receptor Genes in HIV-Infected and HIV-Tuberculosis Co-Infected Individuals in Sub-Saharan Africa
Machado LR; Bowdrey J; Ngaimisi E; Habtewold A; Minzi O; Makonnen E; Yimer G; Amogne W; Mugusi S; Janabi M; Aderaye G; Mugusi F; Viskaduraki M; Aklillu E; Hollox EJ
Article: DRUG METABOLISM AND PHARMACOKINETICS. 2013;28(2):93-97
Comparisons of CYP2A6 Genotype and Enzyme Activity between Swedes and Koreans
Djordjevic N; Antonio Carrillo J; van den Broek MPJ; Kishikawa J; Roh H-K; Bertilsson L; Aklillu E
Article: PLOS ONE. 2013;8(7):e67946
Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations
Ngaimisi E; Habtewold A; Minzi O; Makonnen E; Mugusi S; Amogne W; Yimer G; Riedel K-D; Janabi M; Aderaye G; Mugusi F; Bertilsson L; Aklillu E; Burhenne J
Article: PHARMACOGENOMICS JOURNAL. 2012;12(6):499-506
High plasma efavirenz level and CYP2B6^*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naive HIV patients from Ethiopia: a prospective cohort study
Yimer G; Amogne W; Habtewold A; Makonnen E; Ueda N; Suda A; Worku A; Haefeli WE; Burhenne J; Aderaye G; Lindquist L; Aklillu E
Article: JOURNAL OF CLINICAL PHARMACOLOGY. 2012;52(10):1527-1534
Comparison of N-Acetyltransferase-2 Enzyme Genotype-Phenotype and Xanthine Oxidase Enzyme Activity Between Swedes and Koreans
Djordjevic N; Carrillo JA; Roh H-K; Karlsson S; Ueda N; Bertilsson L; Aklillu E
Article: JOURNAL OF INFECTIOUS DISEASES. 2012;206(7):1012-1019
β-defensin Genomic Copy Number Is Associated With HIV Load and Immune Reconstitution in Sub-Saharan Africans
Hardwick RJ; Amogne W; Mugusi S; Yimer G; Ngaimisi E; Habtewold A; Minzi O; Makonnen E; Janabi M; Machado LR; Viskaduraki M; Mugusi F; Aderaye G; Lindquist L; Hollox EJ; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012;68(7):1033-1042
Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes
Hatta FHM; Teh LK; Hellden A; Hellgren KE; Roh H-K; Salleh MZ; Aklillu E; Bertilsson L
Article: PHARMACOGENETICS AND GENOMICS. 2012;22(5):389-395
PharmGKB summary: caffeine pathway
Thorn CF; Aklillu E; McDonagh EM; Klein TE; Altman RB
Article: ANTIVIRAL THERAPY. 2012;17(2):265-274
Risk factors for mortality among HIV-positive patients with and without active tuberculosis in Dar es Salaam, Tanzania
Mugusi SF; Ngaimisi E; Janabi MY; Mugusi FM; Minzi OMS; Sasi PG; Bakari M; Lindquist L; Aklillu E; Sandstrom EG
Article: PHARMACOGENETICS AND GENOMICS. 2012;22(1):73-77
PharmGKB summary: very important pharmacogene information for CYP1A2
Thorn CF; Aklillu E; Klein TE; Altman RB
Article: PLOS ONE. 2012;7(7):e40180
Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania
Mugusi S; Ngaimisi E; Janabi M; Minzi O; Bakari M; Riedel K-D; Burhenne J; Lindquist L; Mugusi F; Sandstrom E; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2011;67(11):1139-1145
Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method
Aklillu E; Mugusi S; Ngaimisi E; Hoffmann MM; Koenig S; Ziesenitz V; Mikus G; Haefeli WE; Weiss J
Article: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2011;66(10):2350-2361
Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients
Habtewold A; Amogne W; Makonnen E; Yimer G; Riedel K-D; Ueda N; Worku A; Haefeli WE; Lindquist L; Aderaye G; Burhenne J; Aklillu E
Journal article: CLINICAL PHARMACOKINETICS. 2011;50(9):624
Erratum to: HIV/AIDS patients display lower relative bioavailability of efavirenz than healthy subjects
Mukonzo JK; Nanzigu S; Rekić D; Waako P; Röshammar D; Ashto M; Ogwal-Okeng J; Gustafsson LL; Aklillu E
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2011;90(3):406-413
Effect of Rifampicin and CYP2B6 Genotype on Long-Term Efavirenz Autoinduction and Plasma Exposure in HIV Patients With or Without Tuberculosis
Ngaimisi E; Mugusi S; Minzi O; Sasi P; Riedel K-D; Suda A; Ueda N; Janabi M; Mugusi F; Haefeli WE; Bertilsson L; Burhenne J; Aklillu E
Article: CLINICAL PHARMACOKINETICS. 2011;50(8):531-540
HIV/AIDS Patients Display Lower Relative Bioavailability of Efavirenz than Healthy Subjects
Mukonzo JK; Nanzigu S; Rekic D; Waako P; Roshammar D; Ashton M; Ogwal-Okeng J; Gustafsson LL; Aklillu E
Article: JOURNAL OF CLINICAL PHARMACOLOGY. 2011;51(7):994-1003
N-acetyltransferase-2 (NAT2) Gene Polymorphisms and Enzyme Activity in Serbs: Unprecedented High Prevalence of Rapid Acetylators in a White Population
Djordjevic N; Antonio Carrillo J; Ueda N; Gervasini G; Fukasawa T; Suda A; Jankovic S; Aklillu E
Article: PHARMACOGENOMICS JOURNAL. 2011;11(2):130-137
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians
Gebeyehu E; Engidawork E; Bijnsdorp A; Aminy A; Diczfalusy U; Aklillu E
Article: PLOS ONE. 2011;6(12):e27810
Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients
Yimer G; Ueda N; Habtewold A; Amogne W; Suda A; Riedel K-D; Burhenne J; Aderaye G; Lindquist L; Makonnen E; Aklillu E
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2010;88(5):676-684
Long-Term Efavirenz Autoinduction and Its Effect on Plasma Exposure in HIV Patients
Ngaimisi E; Mugusi S; Minzi OM; Sasi P; Riedel K-D; Suda A; Ueda N; Janabi M; Mugusi F; Haefeli WE; Burhenne J; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2010;66(9):871-877
CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking
Ramsjo M; Aklillu E; Bohman L; Ingelman-Sundberg M; Roh H-K; Bertilsson L
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2010;66(7):697-703
Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2-163C>A polymorphism
Djordjevic N; Ghotbi R; Jankovic S; Aklillu E
Article: THERAPEUTIC DRUG MONITORING. 2010;32(3):346-352
Genetic Variations in ABCB1 and CYP3A5 as well as Sex Influence Quinine Disposition Among Ugandans
Mukonzo JK; Waako P; Ogwal-Okeng J; Gustafsson LL; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2010;66(6):571-578
In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population
Djordjevic N; Carrillo JA; Gervasini G; Jankovic S; Aklillu E
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2010;66(5):465-474
Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure-an impact similar to male gender or smoking in schizophrenic patients
Ghotbi R; Mannheimer B; Aklillu E; Suda A; Bertilsson L; Eliasson E; Osby U
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2009;68(5):690-699
A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans
Mukonzo JK; Roshammar D; Waako P; Andersson M; Fukasawa T; Milani L; Svensson JO; Ogwal-Okeng J; Gustafsson LL; Aklillu E
Article: PHARMACOGENOMICS JOURNAL. 2009;9(3):208-217
Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers
Ghotbi R; Gomez A; Milani L; Tybring G; Syvanen A-C; Bertilsson L; Ingelman-Sundberg M; Aklillu E
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19(5):363-370
MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs
Hilli J; Heikkinen T; Rontu R; Lehtimaki T; Kishida I; Aklillu E; Bertilsson L; Vahlberg T; Laine K
Article: PHARMACOGENETICS AND GENOMICS. 2009;19(4):267-275
Association of MAOA gene functional promoter polymorphism with CSF dopamine turnover and atypical depression
Aklillu E; Karlsson S; Zachrisson OO; Ozdemir V; Agren H
Article: HUMAN MUTATION. 2008;29(9):1147-1153
Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme
Chavarria-Soley G; Sticht H; Aklillu E; Ingelman-Sundberg M; Pasutto F; Reis A; Rautenstrauss B
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2008;64(4):381-385
Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes
Djordjevic N; Ghotbi R; Bertilsson L; Jankovic S; Aklillu E
Article: PLOS ONE. 2008;3(3):e1809
Anti-Tuberculosis Therapy-Induced Hepatotoxicity among Ethiopian HIV-Positive and Negative Patients
Yimer G; Aderaye G; Amogne W; Makonnen E; Aklillu E; Lindquist L; Yamuah L; Feleke B; Aseffa A
Article: PHARMACOGENETICS AND GENOMICS. 2008;18(3):201-208
4β-Hydroxycholesterol is a new endogenous CYP3A marker:: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
Diczfalusy U; Miura J; Roh H-K; Mirghani RA; Sayi J; Larsson H; Bodin KG; Allqvist A; Jande M; Kim J-W; Aklillu E; Gustafsson LL; Bertilsson L
Article: PHARMACOGENETICS AND GENOMICS. 2007;17(11):989-993
CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine
Aklillu E; Kalow W; Endrenyi L; Harper P; Miura J; Ozdemir V
Article: NEUROPSYCHOPHARMACOLOGY. 2007;32(10):2143-2151
Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression
Kishida I; Aklillu E; Kawanishi C; Bertilsson L; Agren H
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2007;81(5):708-712
CYP3A5 genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir
Josephson F; Allqvist A; Janabi M; Sayi J; Aklillu E; Jande M; Mahindi M; Burhenne J; Bottiger Y; Gustafsson LL; Haefeli WE; Bertilsson L
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2007;63(6):537-546
Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans
Ghotbi R; Christensen M; Roh H-K; Ingelman-Sundberg M; Aklillu E; Bertilsson L
Article: PHARMACOGENETICS AND GENOMICS. 2006;16(9):637-645
CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population
Mirghani RA; Sayi J; Aklillu E; Allqvist A; Jande M; Wennerholm A; Eriksen J; Herben VMM; Jones BC; Gustafsson LL; Bertilsson L
Article: PHARMACOGENETICS AND GENOMICS. 2006;16(5):359-367
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype
Jiang Z; Dragin N; Jorge-Nebert LF; Martin MV; Guengerich FP; Aklillu E; Ingelman-Sundberg M; Hammons GJ; Lyn-Cook BD; Kadlubar FF; Saldana SN; Sorter M; Vinks AA; Nassr N; von Richter O; Jin L; Nebert DW
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2006;79(1):103-113
A common novel CTP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
Sim SC; Risinger C; Dahl ML; Aklillu E; Christensen M; Bertilsson L; Ingelman-Sundberg M
Article: CANCER RESEARCH. 2005;65(12):5105-5111
Characterization of common CYP1B1 variants with different capacity for benzo[a] pyrene-7,8-dihydrodiol epoxide formation from benzo[a]pyrene
Aklillu E; Ovrebo S; Botnen IV; Otter C; Ingelman-Sundberg M
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2003;59(7):533-536
Xanthine oxidase activity is influenced by environmental factors in Ethiopians
Aklillu E; Carrillo JA; Makonnen E; Bertilsson L; Ingelman-Sundberg M
Article: MOLECULAR PHARMACOLOGY. 2003;64(3):659-669
Genetic polymorphism of CYP1A2 in ethiopians affecting induction and expression: Characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1
Aklillu E; Carrillo JA; Makonnen E; Hellman K; Pitarque M; Bertilsson L; Ingelman-Sundberg M
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2002;58(8):555-558
Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations
Yasar Ü; Aklillu E; Canaparo R; Sandberg M; Sayi J; Roh HK; Wennerholm A
Journal article: DRUG NEWS AND PERSPECTIVES. 2002;15(8):528-534
Recent Progress in Drug Metabolism Research.
Aklillu E; Hidestrand M; Ingelman-Sundberg M; Malmebo S; Westlind A
Article: PHARMACOGENETICS AND GENOMICS. 2002;12(5):375-383
Evidence for environmental influence on CYP2D6-catalysed debrisoquine hydroxylation as demonstrated by phenotyping and genotyping of Ethiopians living in Ethiopia or in Sweden
Aklillu E; Herrlin K; Gustafsson LL; Bertilsson L; Ingelman-Sundberg M
Article: MOLECULAR PHARMACOLOGY. 2002;61(3):586-594
Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population
Aklillu E; Oscarson M; Hidestrand M; Leidvik B; Otter C; Ingelman-Sundberg M
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2001;52(4):447-450
Genetic polymorphism of cytochrome P4502C9 in a Caucasian and a black African population
Scordo MG; Aklillu E; Yasar U; Dahl ML; Spina E; Ingelman-Sundberg M
Article: PHARMACOGENETICS AND GENOMICS. 1996;6(6):521-526
S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among ethiopians
Persson I; Aklillu E; Rodrigues F; Bertilsson L; IngelmanSundberg M
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1996;278(1):441-446
Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
Aklillu E; Persson I; Bertilsson L; Johansson I; Rodrigues F; IngelmanSundberg M
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Alla övriga publikationer

Letter: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2024;80(7):1111-1112
"Always look at the outliers": in memoriam Leif Bertilsson
Stingl J; Aklillu E; Masimirembwa C; Kek TL
Review: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2024;141:107002
Screening for latent tuberculosis in migrants-status quo and future challenges
Petersen E; Al-Abri S; Al-Jardani A; Memish ZA; Aklillu E; Ntoumi F; Mwaba P; Wejse C; Zumla A; Al-Yaquobi F
Conference publication: 2023;:a37.3-a3a38
PA-118 Safety monitoring during mass drug administration: adverse events following the use of Ivermectin, Diethylcarbamazine and Albendazole for the control of lymphatic filariasis in Kenya
Khaemba C; Barry A; Omondi W; Kirui E; Mandale M; Oluka M; Gurumurthy P; Njenga S; Guantai A; Aklillu E
Conference publication: 2023;:a35.2-a3a35
PA-96 Surveillance of hematological and biochemical changes following mass Ivermectin and Albendazole administration for the control of lymphatic filariasis in endemic communities of Tanzania
Fimbo AM; Minzi O; Aklillu E
Conference publication: 2023;:a32.1-a3a32
PA-74 Efficacy of single dose albendazole for the treatment of soil-transmitted infections among school children in Southern Ethiopia
Gebreyesus TD; Makonnen E; Tadele T; Mekete K; Gashaw H; Gerba H; Aklillu E
Editorial comment: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2023;131:180-182
End of the Bedaquiline patent - a crucial development for moving forward affordable drugs, diagnostics, and vaccines for infectious diseases in low- and middle-income countries
Petersen E; Hui DS; Nachega JB; Ntoumi F; Goletti D; Aklillu E; Sharma A; Nyirenda T; Yeboah-Manu D; Satta G; da Costa C; Azhar EI; Bockarie M; Al-Abri S; Mchugh TD; Rodriguez-Morales AJ; Varghese G; Zumla A
Editorial comment: THE LANCET RESPIRATORY MEDICINE. 2022;10(6):533-536
Optimising tuberculosis care for refugees affected by armed conflicts Comment
Castro KG; Ditiu L; Sahu S; Ntoumi F; Tiberi S; O'Kane CM; Akkerman O; Manika K; Mwaba P; Forsman LD; Petersen E; Aklillu E; Azhar EI; Cirillo DM; Migliori G-B; Abbara A; Zumla A
Editorial comment: THE LANCET INFECTIOUS DISEASES. 2022;22(4):442-444
World Tuberculosis Day 2022: aligning COVID-19 and tuberculosis innovations to save lives and to end tuberculosis
Ntoumi F; Nachega JB; Aklillu E; Chakaya J; Felker I; Amanullah F; Yeboah-Manu D; Castro KG; Zumla A
Editorial comment: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2022;114:268-272
Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529)-highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts
Petersen E; Ntoumi F; Hui D; Abubakar A; Kramer LD; Obiero C; Tambyah PA; Blumberg L; Yapi R; Al-Abri S; Pinto TDCA; Yeboah-Manu D; Haider N; Asogun D; Velavan TP; Kapata N; Bates M; Ansumana R; Montaldo C; Mucheleng'anga L; Tembo J; Mwaba P; Himwaze C; Hamid MMA; Mfinanga S; Mboera L; Raj T; Aklillu E; Veas F; Edwards S; Kaleebu P; McHugh TD; Chakaya J; Nyirenda T; Bockarie M; Nyasulu PS; Wejse C; Muyembe-Tamfum J-J; Azhar EI; Maeurer M; Nachega JB; Kock R; Ippolito G; Zumla A
Review: PHARMACOGENOMICS AND PERSONALIZED MEDICINE. 2022;15:561-571
Effect of Genetic Variations in Drug-Metabolizing Enzymes and Drug Transporters on the Pharmacokinetics of Rifamycins: A Systematic Review
Sileshi T; Mekonen G; Makonnen E; Aklillu E
Review: EXPERT OPINION ON DRUG METABOLISM AND TOXICOLOGY. 2021;17(9):1125-1138
The impact of catha edulis (vahl) forssk. ex endl. (celestraceae) (khat) on pharmacokinetics of clinically used drugs
Aklillu E; Engidawork E
Preprint: RESEARCH SQUARE. 2020
Effect of Sulfadoxine-Pyrimethamine doses for prevention of malaria during pregnancy in hypoendemic area in Tanzania
Mikomangwa WP; Minzi O; Mutagonda R; Baraka V; Mlugu E; Aklillu E; Kamuhabwa AAR
Preprint: RESEARCH SQUARE. 2019
Effect of Sulfadoxine-Pyrimethamine doses for prevention of malaria during pregnancy in hypoendemic area in Tanzania
Mikomangwa WP; Minzi O; Mutagonda R; Baraka V; Mlugu EM; Aklillu E; Kamuhabwa AAR
Letter: HIV MEDICINE. 2019;20(7):e13-e14
Rebuttal: Response to the comments by Buck et al. on our published article: Hepatic and renal toxicity and associated factors among HIV-infected children on antiretroviral therapy: a prospective cohort study; HIV Medicine (2019), 20, 147-156
Tadesse BT; Foster A; Aklillu E
Review: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2019;85(3):467-475
Conference report: pharmacogenomics in special populations at WCP2018
Suarez-Kurtz G; Aklillu E; Saito Y; Somogyi AA
Conference publication: TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE. 2019;113:S270-S271
HIV AND CART ASSOCIATED DYSLIPIDEMIA AMONG HIV INFECTED CHILDREN
Tadesse BT; Foster BA; Bizuayehu T; Ayalew F; Meskel GH; Jerene D; Makonnen E; Aklillu E
Conference publication: HIV MEDICINE. 2019;20:285
Rifampicin pharmacokinetics and pharmacogenetics in Ugandan patients with multi-drug resistant tuberculosis
Mukonzo JK; Kengo A; Kutesa R; Nanzigu S; Pohanka A; Hugh M; Zumla A; Aklillu E
Preprint: AAS OPEN RES. 2019
African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa
Dandara C; Masimirembwa C; Haffani Y; Ogutu B; Mabuka J; Aklillu E; Bolaji O; H3Africa
Conference publication: DRUG SAFETY. 2018;41(11):1107-1108
The Proforma Project Presentation
Aklillu E
Conference publication: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY. 2018;21:122
Efavirenz plasma exposure and immunologic outcome during anti-tuberculosis co-therapy: role of ethnicity and pharmacogenetic variations
Mugusi S; Amogne W; Habtewold A; Ngaimisi E; Yimer G; Minzi O; Makonnene E; Mugusi F; Sudfeld C; Janabi M; Burhenne J; Aklillu E
Review: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2017;21(3):123-131
Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation
Petros Z; Makonnen E; Aklillu E
Conference publication: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2017;101(S1):S66-S67
POPULATION PHARMACOKINETICS OF A MAJOR METABOLITE OF EFAVIRENZ, 8-HYDROXY-EFAVIRENZ, IN PLASMA AND PERIPHERAL BLOOD MONONUCLEAR CELLS
Habtewold A; Aklillu E; Makonnen E; Yimer G; Bertilsson L; Burhenne J; Owen J
Editorial comment: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2016;20(9):493-495
Precision Medicine 2.0: The Rise of Glocal Innovation, Superconnectors, and Design Thinking
Dandara C; Endrenyi L; Kolker E; Hekim N; Steuten LMG; Gungor K; Aklillu E; Ozdemir V
Letter: OMICS A JOURNAL OF INTEGRATIVE BIOLOGY. 2016;20(4):259-262
An Open Letter in Support of Transformative Biotechnology and Social Innovation: SANKO University Innovation Summit in Medicine and Integrative Biology, Gaziantep, Turkey, May 5-7, 2016
Saygili EI; Abou-Zeid AH; Akkin SM; Aklillu E; Barlas IO; Borda-Rodriguez A; Boschele FA; Cetin Z; Coskun E; Coskun Y; Dagli G; Dai TU; Dandara C; Dereli T; Elbeyli L; Endrenyi L; Eyigun CP; Georgakilas A; Gunbulut B; Gungor K; Guzelbey A; Hekim C; Huzair F; Kimyon S; Karakas U; Lin B; LLerena A; Masimirembwa C; McNally R; Mete A; Sancar P; Srivastava S; Steuten LM; Tanriover O; Tyfield D; Tore VI; Vuruskan D; Wang W; Warnich L; Wonkam A; Yildirim YZ; Yilmaz I; Sinav A; Hekim N
Editorial comment: CLINICAL INFECTIOUS DISEASES. 2015;61(9):1432-1438
Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates
Zumla A; Maeurer M; Chakaya J; Hoelscher M; Ntoumi F; Rustomjee R; Vilaplana C; Yeboah-Manu D; Rasolofo V; Munderi P; Singh N; Aklillu E; Padayatchi N; Macete E; Kapata N; Mulenga M; Kibiki G; Mfinanga S; Nyirenda T; Mboko L; Garcia-Basteiro AL; Rakotosamimanana N; Bates M; Mwaba P; Reither K; Gagneux S; Edwards S; Mfinanga E; Abdulla S; Cardona P-J; Russell JBW; Gant V; Noursadeghi M; Elkington P; Bonnet M; Menendez C; Dieye TN; Diarra B; Maiga A; Aseffa A; Parida S; Wejse C; Petersen E; Kaleebu P; Oliver M; Craig G; Corrah T; Tientcheu L; Antonio M; McHugh TD; Sheikh A; Ippolito G; Ramjee G; Kaufmann SHE; Churchyard G; Steyn AJC; Grobusch MP; Sanne I; Martinson N; Mandansein R; Wilkinson RJ; Wallis RS; Mayosi B; Schito M
Editorial comment: NATURE REVIEWS DRUG DISCOVERY. 2015;14(8):511-512
Towards host-directed therapies for tuberculosis
Zumla A; Maeurer M; Chakaya J; Hoelscher M; Ntoumi F; Rustomjee R; Vilaplana C; Yeboah-Manu D; Rasolofo V; Munderi P; Singh N; Aklillu E; Padayatchi N; Macete E; Kapata N; Mulenga M; Kibiki G; Mfinanga S; Nyirenda T; Maboko L; Garcia-Basteiro A; Rakotosamimanana N; Bates M; Mwaba P; Reither K; Gagneux S; Edwards S; Mfinanga E; Abdulla S; Cardona P-J; Russell JBW; Gant V; Noursadeghi M; Elkington P; Bonnet M; Menendez C; Dieye TN; Diarra B; Maiga A; Aseffa A; Parida S; Wejse C; Petersen E; Kaleebu P; Oliver M; Craig G; Corrah T; Tientcheu L; Antonio M; Rao M; McHugh TD; Sheikh A; Ippolito G; Ramjee G; Kaufmann SHE; Churchyard G; Steyn A; Grobusch M; Sanne I; Martinson N; Madansein R; Wilkinson RJ; Mayosi B; Schito M; Wallis RS
Conference publication: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. 2015;42:S25
Pharmacogenetic-Based Pharmacokinetic Modeling of Plasma and Intracellular Concentrations of Efavirenz on Adult Ethiopian HIV and TB/HIV Patients
Habtewold A; Aklillu E; Makonnen E; Amogne W; Yimer G; Aderaye G; Bertilsson L; Burhenne J; Owen JS
Editorial comment: THE LANCET INFECTIOUS DISEASES. 2015;15(1):11-13
Genesis of EDCTP2
Zumla A; Makanga M; Nyirenda T; Beattie P; Olesen OF; Breugelmans JG; Aklillu E; Corrah T; Mgone C
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;115:232-233
TB-HIV CO-INFECTION AND CONCOMITANT ANTI-TB THERAPY AND HAART INCREASES THE RISK FOR DRUG INDUCED LIVER INJURY: A PROSPECTIVE FOUR-ARM COHORT STUDY
Ali G; Gry M; Amogne W; Makonnen E; Habtewold A; Petros Z; Aderaye G; Schuppe-Koistinen I; Lindquist L; Aklillu E
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;115:166
INVESTIGATING THE DETERMINANTS OF EFAVIRENZ PHARMACOKINETIC PARAMETERS AFTER LONG TERM TREATMENT WITH AND WITHOUT RIFAMPICIN AMONG TANZANIAN HIV/TB AND HIV PATIENTS
Ngaimisi E; Minzi O; Mugusi S; Janabi M; Sasi P; Mugusi F; Bertilsson L; Aklillu E; Burhenne J
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2014;115:73
IS THERE A NEED FOR EFAVIRENZ DOSAGE ADJUSTMENT DURING CONCOMITANT RIFAMPICIN BASED ANTITUBERCULOSIS THERAPY? FINDINGS FROM THE HIV-TB PHARMAGENE STUDY
Habtewold A; Makonnen E; Amogne W; Ali G; Aderaye G; Bertilsson L; Burhenne J; Aklillu E
Conference publication: TOXICOLOGY LETTERS. 2012;211:S48
Qualification of new biomarkers for drug-induced liver injury in a human cohort
Thulin P; Gry M; Nordahl G; Yimer G; Linder S; Aklillu E; Glinghammar B; Schuppe-Koistinen I
Conference publication: TOXICOLOGY LETTERS. 2012;211:S9
Pharmacogenomic biomarkers for drug induced liver injury
Aklillu E
Conference publication: TROPICAL MEDICINE AND INTERNATIONAL HEALTH. 2012;17:22-23
Optimization of TB and HIV co-treatment: pharmacokinetic and pharmacogenetic aspects of interaction between rifampicin and efavirenz (EFV)
Aklillu E
Conference publication: IMMUNOLOGY. 2011;135:141
β-Defensin genomic copy number is associated with HIV viral load and immune reconstitution in sub-Saharan Africans
Hardwick R; Amogne W; Mugusi S; Yimer G; Ngaimisi E; Habtewold A; Minzi O; Makonnen E; Janabi M; Machado L; Mugusi F; Aderaye G; Lindquist L; Hollox E; Aklillu E
Corrigendum: CLINICAL PHARMACOKINETICS. 2011;50(9):624
HIV/AIDS patients display lower relative bioavailability of efavirenz than healthy subjects (vol 50, pg 531, 2011)
Mukonzo JK; Nanzigu S; Rekic D; Waako P; Roeshammar D; Ashton M; Ogwal-Okeng J; Gustafsson LL; Aklillu E
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2011;109:23
XANTHINE OXIDASE AND N-ACETYLTRANSFERASE-2 ENZYME ACTIVITIES IN SWEDES AND KOREANS: AN INTER-ETHNIC COMPARISON
Djordjevic N; Carrillo JA; Gervasini G; Ueda N; Roh H-K; Aklillu E
Conference publication: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2009;68:7
THE AUTO INDUCTION OF EFAVIRENZ METABOLISM AND THE RESULTING EFFECT ON THE EFAVIRENZ STEADY STATE LEVELS IN TANZANIAN PATIENTS
Ngaimisi E; Mugusi S; Minzi O; Sasi P; Janabi M; Mugusi F; Bakari M; Aris E; Sandstrom E; Bertilsson L; Burhenne J; Aklillu E
Conference publication: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2009;68:6
STEADY STATE EFAVIRENZ PHARMACOKINETICS PROFILE AMONG HIV PATIENTS IN ETHIOPIA
Eyakem A; Amogne W; Yimer G; Makonnen E; Aderaye G; Bertilsson L; Burhenne J; Aklillu E
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2009;105:81
N-ACETYLTRANSFERASE-2 (NAT2) GENE POLYMORPHISMS AND ENZYME ACTIVITY IN SERBS: UNPRECEDENTED HIGH PREVALENCE OF RAPID ACETYLATORS IN A WHITE POPULATION
Djordjevic N; Carrillo JA; Gervasini G; Jankovic S; Aklillu E
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2009;105:21-22
CORRELATION OF CYP2A6 ENZYME ACTIVITY WITH GENOTYPE AND CIGARETTE SMOKING IN SERBS
Djordjevic N; Carrillo JA; Gervasini G; Jankovic S; Aklillu E
Letter: BLOOD. 2008;111(7):3903-3904
VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals
Aklillu E; Leong C; Loebstein R; Halkin H; Gak E
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S328
Monoamine metabolites level in CSF are related to the 5-HTT gene polymorphism in treatment-resistant depression
Kishida I; Aklillu E; Kawanishi C; Bertilsson L; Agren H
Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S98
Distribution and concordance of phenotypically and genotypically determined acetylation status on patients taking anti-tuberculosis drugs in Ethiopia
Yimer G; Golka K; Aseffa A; Aklillu E; Makonnen E; Amogne W; Bobosha K; Rane A; LindquiSt L; Aderaye G
Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S92
Anti-tubercular drug-induced hepatotoxicity in HIV-positive and negative patients
Yimer G; Aseffa A; Aklillu E; Makonnen E; Amogne W; Bobosha K; Golka K; Rane A; Lindquist L; Aderaye G
Meeting abstract: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 2006;21(4):A33
CYP3A4 and 3A5 catalysed alprazolam metabolism in vitro and in vivo
Miura J; Aklillu E; Allqvist A; Gustafsson LL; Jande M; Mirghani RA; Sayi J; Wennerholm A; Widen J; Bertilsson L
Review: EXPERT OPINION ON PHARMACOTHERAPY. 2006;7(2):119-133
Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines
Ozdemir V; Aklillu E; Mee S; Bertilsson L; Albers LJ; Graham JE; Caligiuri M; Lohr JB; Reist C
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):413
Monoamine metabolites in CSF are related to serotonin transporter promoter gene polymorphism in treatment-resistant major depression.
Kishida I; Aklillu E; Bertilsson L; Ågren H; Kawanishi C
Conference publication: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 2004;31(11):A220
Genetic polymorphisms of CYP1A2 and xanthine oxidase in ethiopians affecting expression: Characterization of novel CYP1A2 haplotypes
Aklillu E; Carrillo JA; Mekonen E; Bertilsson L; Ingelman-Sundberg M
Thesis / dissertation: 2003
Pharmacogenetics of drug metabolizing enzymes with special emphasis on Ethiopians
Aklillu, Eleni
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Forskningsbidrag

Building resilient research ethics, Diagnostics and medicines regulatory capacity during routine and public health emergency periods (BREEDIME)
Global Health EDCTP3 Joint Undertaking
1 June 2024 - 31 May 2026
Safety and efficacy of Dolutegravir and EFV400 for pregnant and breast feeding women: a randomized non-inferiority clinical trial (PREGART)
EDCTP
1 June 2018 - 31 December 2025
Pharmacovigilance infrastructure and post-marketing surveillance system capacity building for regional medicine regulatory harmonization in East Africa
European & Developing Countries Clinical Trials Partnership
1 March 2018 - 31 August 2024
Randomized clinical trial to identify optimal pediatric efavirenz dosage to treat HIV infected infant and children in Africa
Swedish Research Council
1 January 2016 - 31 December 2019
Healthcare associated infections, antimicrobial use and resistance in Ethiopia: an intervention study for rational antimicrobials use, prevention of resistance and limit their spread.
Swedish Research Council
1 January 2012 - 31 December 2014
Vårdrelaterade infektioner, antimikrobiella användningen och multiresistenta bakterier-en interventionsstudie för rationell antibiotika användning, förebyggande av infektion utbrott
Swedish Research Council
1 January 2012 - 31 December 2014
Metabolism, transport and effects of drugs - Pharmacogenetic, interethnic, and clinical aspects
Swedish Research Council
1 January 2010 - 31 December 2012

Anställningar

Professor, Global folkhälsa, Karolinska Institutet, 2023-

Examina och utbildning

Docent, Farmakologi, Karolinska Institutet, 2009
MEDICINE DOKTORSEXAMEN, Institutet för miljömedicin, Karolinska Institutet, 2003

Uppdrag

Forskargruppsledare, Global Health Pharmacology and Therapeutics (GH-Pharma) – Eleni Aklillu's research group, Department of Global Public Health, Karolinska Institutet, 2023-

Handledare

Joseph Kabatende, Pharmacovigilance of mass drug administration for the control of schistosomiasis and soil transmitted helminths in Rwanda., https://openarchive.ki.se/xmlui/handle/10616/48601

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