David Rizo Roca

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Artiklar

Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2025;1871(1):167539
Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy.
Tocantins C; Martins JD; Rodrigues ÓM; Grilo LF; Diniz MS; Stevanovic-Silva J; Beleza J; Coxito P; Rizo-Roca D; Santos-Alves E; Moreno AJ; Ascensão A; Magalhães J; Oliveira PJ; Pereira SP
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(768):eado3022
Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes
Rizo-Roca D; Guimaraes DSPSF; Pendergrast LA; Di Leo N; Chibalin AV; Maqdasy S; Ryden M; Naslund E; Zierath JR; Krook A
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347
Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6
Guimaraes DSPSF; Barrios NMF; de Oliveira AG; Rizo-Roca D; Jollet M; Smith JAB; Araujo TR; da Cruz MV; Marconato E; Hirabara SM; Vieira AS; Krook A; Zierath JR; Silveira LR
Article: NATURE METABOLISM. 2024;6(7):1329-1346
Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Lecoutre S; Maqdasy S; Rizo-Roca D; Renzi G; Vlassakev I; Alaeddine LM; Higos R; Jalkanen J; Zhong J; Zareifi DS; Frendo-Cumbo S; Massier L; Hodek O; Juvany M; Moritz T; de Castro Barbosa T; Omar-Hmeadi M; Lopez-Yus M; Merabtene F; Abatan JB; Marcelin G; El Hachem E-J; Rouault C; Bergo MO; Petrus P; Zierath JR; Clement K; Krook A; Mejhert N; Ryden M
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023;53(11):e14069
Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation
Tocantins C; Martins JD; Rodrigues OM; Grilo LF; Diniz MS; Stevanovic-Silva J; Beleza J; Coxito P; Rizo-Roca D; Santos-Alves E; Rios M; Carvalho L; Moreno AJ; Ascensao A; Magalhaes J; Oliveira PJ; Pereira SP
Article: DIABETES. 2022;71(4):624-636
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Dollet L; Kuefner M; Caria E; Rizo-Roca D; Pendergrast L; Abdelmoez AM; Karlsson HKR; Bjornholm M; Dalbram E; Treebak JT; Harada J; Naslund E; Ryden M; Zierath JR; Pillon NJ; Krook A
Article: NATURE METABOLISM. 2022;4(2):190-202
Impaired phosphocreatine metabolism in white adipocytes promotes inflammation
Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Ryden M
Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022;19(1):498
Benefits on Hematological and Biochemical Parameters of a High-Intensity Interval Training Program for a Half-Marathon in Recreational Middle-Aged Women Runners
Bonet JB; Javierre C; Guimaraes JT; Martins S; Rizo-Roca D; Beleza J; Viscor G; Pages T; Magalhaes J; Torrella JR
Article: DIABETOLOGIA. 2021;64(9):2077-2091
Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes
Sjogren RJO; Rizo-Roca D; Chibalin AV; Chorell E; Furrer R; Katayama S; Harada J; Karlsson HKR; Handschin C; Moritz T; Krook A; Naslund E; Zierath JR
Article: CIRCULATION-HEART FAILURE. 2020;13(11):e006170
Mitochondrial Reversible Changes Determine Diastolic Function Adaptations During Myocardial (Reverse) Remodeling
Miranda-Silva D; Rodrigues PG; Alves E; Rizo D; Fonseca ACRG; Lima T; Baganha F; Conceicao G; Sousa C; Goncalves A; Miranda I; Vasques-Novoa F; Magalhaes J; Leite-Moreira A; Falcao-Pires I
Article: BEHAVIOURAL BRAIN RESEARCH. 2020;379:112358
Physical exercise mitigates behavioral impairments in a rat model of sporadic Alzheimer's disease
Bernardo TC; Beleza J; Rizo-Roca D; Santos-Alves E; Leal C; Martins MJ; Ascensao A; Magalhaes J
Article: MITOCHONDRION. 2019;47:103-113
Physical exercise positively modulates DOX-induced hepatic oxidative stress, mitochondrial dysfunction and quality control signaling
Estela S-A; David R-R; Ines M-A; Pedro C; Sandra M; Joao G; Oliveira Paulo J; Torrella Joan R; Magalhaes Jose A; Antonio A
Article: AQUACULTURE. 2019;501:397-403
Sustained swimming enhances white muscle capillarisation and growth by hyperplasia in gilthead sea bream (Sparus aurata) fingerlings
Moya A; Torrella JR; Fernandez-Borras J; Rizo-Roca D; Millan-Cubillo A; Velez EJ; Arcas A; Gutierrez J; Blasco J
Article: PLOS ONE. 2019;14(7):e0219167
A three-criteria performance score for rats exercising on a running treadmill
Gabriel Rios-Kristjansson J; Rizo-Roca D; Mist Kristjansdottir K; Andres Nunez-Espinosa C; Ramon Torrella J; Pages T; Viscor G
Article: FRONTIERS IN PHYSIOLOGY. 2019;10:593
Self-Paced Free-Running Wheel Mimics High-Intensity Interval Training Impact on Rats' Functional, Physiological, Biochemical, and Morphological Features
Beleza J; Albuquerque J; Santos-Alves E; Fonseca P; Santocildes G; Stevanovic J; Rocha-Rodrigues S; Rizo-Roca D; Ascensao A; Torrella JR; Magalhaes J
Article: HIGH ALTITUDE MEDICINE & BIOLOGY. 2018;19(3):278-285
Additive Effects of Intermittent Hypobaric Hypoxia and Endurance Training on Bodyweight, Food Intake, and Oxygen Consumption in Rats
Cabrera-Aguilera I; Rizo-Roca D; Marques EA; Santocildes G; Pages T; Viscor G; Ascensao AA; Magalhaes J; Torrella JR
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:481
Contractile Activity Is Necessary to Trigger Intermittent Hypobaric Hypoxia-Induced Fiber Size and Vascular Adaptations in Skeletal Muscle
Rizo-Roca D; Bonet JB; Inal B; Rios-Kristjansson JG; Pages T; Viscor G; Torrella JR
Article: AMERICAN JOURNAL OF SPORTS MEDICINE. 2017;45(9):2131-2141
Postinjury Exercise and Platelet-Rich Plasma Therapies Improve Skeletal Muscle Healing in Rats But Are Not Synergistic When Combined
Contreras-Munoz P; Ramon Torrella J; Serres X; Rizo-Roca D; De la Varga M; Viscor G; Martinez-Ibanez V; Luis Peiro J; Jarvinen TAH; Rodas G; Marotta M
Article: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM. 2017;42(7):683-693
Modulation of mitochondrial biomarkers by intermittent hypobaric hypoxia and aerobic exercise after eccentric exercise in trained rats
Rizo-Roca D; Gabriel Rios-Kristjansson J; Nunez-Espinosa C; Santos-Alves E; Magalhaes J; Ascensao A; Pages T; Viscor G; Ramon Torrella J
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2017;122(3):580-592
Intermittent hypobaric hypoxia combined with aerobic exercise improves muscle morphofunctional recovery after eccentric exercise to exhaustion in trained rats
Rizo-Roca D; Rios-Kristjansson JG; Nunez-Espinosa C; Santos-Alves E; Goncalves IO; Magalhaes J; Ascensao A; Pages T; Viscor G; Torrella JR
Article: CURRENT STEM CELL RESEARCH & THERAPY. 2016;11(1):66-71
Vybrant DyeCycle Violet Stain Discriminates Two Different Subsets of CD34+Cells
Nunez-Espinosa C; Garcia-Godoy MD; Ferreira I; Rios-Kristjansson JG; Rizo-Roca D; Rico LG; Rubi-Sans G; Palacio C; Torrella JR; Pages T; Ward MD; Viscor G; Petriz J
Journal article: EUROPEAN JOURNAL OF HISTOCHEMISTRY. 2015;59(4):2544
A semiquantitative scoring tool to evaluate eccentric exercise-induced muscle damage in trained rats.
Rizo-Roca D; Ríos-Kristjánsson JG; Núñez-Espinosa C; Ascensão A; Magalhães J; Torrella JR; Pagès T; Viscor G
Article: NEUROSCIENCE. 2015;301:480-495
PHYSICAL EXERCISE IMPROVES BRAIN CORTEX AND CEREBELLUM MITOCHONDRIAL BIOENERGETICS AND ALTERS APOPTOTIC, DYNAMIC AND AUTO(MITO)PHAGY MARKERS
Marques-Aleixo I; Santos-Alves E; Balca MM; Rizo-Roca D; Moreira PI; Oliveira PJ; Magalhaes J; Ascensao A
Article: LIFE SCIENCES. 2015;135:124-130
Exercise modulates liver cellular and mitochondrial proteins related to quality control signaling
Santos-Alves E; Marques-Aleixo I; Rizo-Roca D; Torrella JR; Oliveira PJ; Magalhaes J; Ascensao A
Article: CLINICAL NUTRITION. 2015;34(2):241-247
Physical exercise antagonizes clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders
Goncalves IO; Passos E; Rocha-Rodrigues S; Torrella JR; Rizo D; Santos-Alves E; Portincasa P; Martins MJ; Ascensao A; Magalhaes J
Article: CURRENT STEM CELL RESEARCH & THERAPY. 2015;10(2):132-139
Effects of Intermittent Hypoxia and Light Aerobic Exercise on Circulating Stem Cells and Side Population, after Strenuous Eccentric Exercise in Trained Rats
Nunez-Espinosa C; Ferreira I; Gabriel Rios-Kristjansson J; Rizo-Roca D; Garcia Godoy MD; Rico LG; Rubi-Sans G; Ramon Torrella J; Pages T; Petriz J; Viscor G
Article: EUROPEAN JOURNAL OF HISTOCHEMISTRY. 2015;59(4):310-316
A semiquantitative scoring tool to evaluate eccentric exercise-induced muscle damage in trained rats
Rizo-Roca D; Rios-Kristajnsson JG; Nunez-Espinosa C; Ascensao A; Magalhaes J; Torrella JR; Pages T; Viscor G
Article: MITOCHONDRION. 2015;20:22-33
Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress
Marques-Aleixo I; La Santos-Alves E; Mariani D; Rizo-Roca D; Padrao AI; Rocha-Rodrigues S; Viscor G; Torrella JR; Ferreira R; Oliveira PJ; Magalhaes J; Ascensao A
Article: BMC GENOMICS. 2014;15(1):1136
Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish
Palstra AP; Rovira M; Rizo-Roca D; Ramon Torrella J; Spaink HP; Planas JV
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2014;54:163-173
Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis
Goncalves IO; Maciel E; Passos E; Torrella JR; Rizo D; Viscor G; Rocha-Rodrigues S; Santos-Alves E; Domingues MR; Oliveira PJ; Ascensao A; Magalhaes J
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2014;44(7):668-677
Exercise mitigates diclofenac-induced liver mitochondrial dysfunction
Santos-Alves E; Marques-Aleixo I; Coxito P; Balca MM; Rizo-Roca D; Rocha-Rodrigues S; Martins S; Torrella JR; Oliveira PJ; Moreno AJ; Magalhaes J; Ascensao A
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;173(1):40-45
Modulation of cardiac mitochondrial permeability transition and apoptotic signaling by endurance training and intermittent hypobaric hypoxia
Magalhaes J; Goncalves IO; Lumini-Oliveira J; Marques-Aleixo I; Passos E; Rocha-Rodrigues S; Machado NG; Moreira AC; Rizo D; Viscor G; Oliveira PJ; Torrella JR; Ascensao A
Article: MITOCHONDRION. 2014;15:40-51
Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments
Goncalves IO; Passos E; Rocha-Rodrigues S; Diogo CV; Torrella JR; Rizo D; Viscor G; Santos-Alves E; Marques-Aleixo I; Oliveira PJ; Ascensao A; Magalhaes J
Article: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2014;192:112-117
Effect of intermittent hypoxia and exercise on blood rheology and oxygen transport in trained rats
Nunez-Espinosa C; Douziech A; Gabriel Rios-Kristjansson J; Rizo D; Ramon Torrella J; Pages T; Viscor G
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Preprint: BIORXIV. 2024
Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes
Rizo-Roca D; Guimarães DS; Pendergrast LA; Di Leo N; Chibalin AV; Maqdasy S; Rydén M; Näslund E; Zierath JR; Krook A
Preprint: BIORXIV. 2023
Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6
Guimarães DSPSF; Barrios NMF; de Oliveira AG; Rizo-Roca D; Jollet M; Smith JAB; Araujo T; da Cruz MV; Junior EM; Hirabara S; Vieira A; Krook A; Zierath J; Silveira L
Conference publication: ACTA PHYSIOLOGICA. 2023;239
Sarcomeric mitochondrial creatine kinase 2 modulates mitochondrial homeostasis and is downregulated in men with type 2 diabetes
Rizo-Roca D; Guimaraes DS; Pendergrast L; Di Leo N; Naslund E; Zierath JR; Krook A
Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S233
Skeletal muscle creatine metabolism is altered in type 2 diabetes
Rizo-Roca D; Pendergrast LA; Chibalin AV; Karlsson HKR; Ryden M; Naslund E; Zierath JR; Krook A
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2021;51:43
Beating cardiovascular disease: Physical exercise performed during obesogenic pregnancy to improve offspring mitochondrial cardiac function
Pereira SP; Diniz MS; Martins JD; Rodrigues OM; Tocantins C; Grilo LF; Stevanovic--Silva J; Beleza J; Coxito P; Rizo-Roca D; Santos--Alves E; Rios M; Moreno AJ; Ascensao A; Magalhaes J; Oliveira PJ
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2021;51:42
The metabolic challenge of pregnancy: A toll on the maternal heart aggravated by Gestational Diabetes Mellitus
Tocantins C; Rodrigues OM; Martins JD; Grilo LF; Diniz MS; Stevanovic-Silva J; Beleza J; Coxito P; Rizo-Roca D; Santos-Alves E; Rios M; Moreno AJ; Ascensao A; Magalhaes A; Oliveira PJ; Pereira SP
Preprint: BIORXIV. 2020
Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes
Sjögren RJO; Rizo-Roca D; Chibalin A; Chorell E; Furrer R; Katayama S; Harada J; Karlsson HKR; Handschin C; Moritz T; Krook A; Näslund E; Zierath J
Book chapter: MITOCHONDRIAL BIOLOGY AND EXPERIMENTAL THERAPEUTICS. 2018;p. 379-406
Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity
Beleza J; Rizo-Roca D; Ascensão A; Magalhães J
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2014;44:86
Effects of intermittent hypobaric hypoxia and light exercise on eccentric exercise-induced muscle damage in trained rats
Rizo-Roca D; Rios-Kristjansson JG; Nunez-Espoinosa C; Ascensao AA; Magalhaes J; Torrella JR; Pages T; Viscor G

Forskningsbidrag

Role of creatine on skeletal muscle metabolism, insulin sensitivity and whole-body energy homeostasis
EFSD/Lilly Young Investigator Research Award Programme
1 October 2022 - 30 September 2024

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