David Rizo Roca
Assistant Professor
E-mail: david.rizo.roca@ki.se
Telephone: +46852482933
Visiting address: Solnavägen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Integrativ Fysiologi, 171 77 Stockholm
About me
- Assistant professor in the Department of Physiology and Pharmacology, David Rizo-Roca’s research is focused on the role of altered metabolites in systemic and skeletal muscle metabolism and mitochondrial function, particularly in the context of Type 2 diabetes.
David studied Biology at the University of Barcelona, where he also did his PhD in the Laboratory of Adaptive Physiology. In 2016, he joined the Laboratory of Metabolism and Exercise of the University of Porto, where he studied the use of exercise as a non-pharmacological tool to counteract mitochondrial dysfunction associated with metabolic disorders. David joined the Karolinska Institutet in 2019 as a Novo Nordisk Postdoctoral Fellow and has been an assistant professor since 2022.
Research
- Recent advances in -omics technologies have allowed us to identify alterations in thousands of molecules in people with Type 2 diabetes. However, whether these molecules (such as metabolites and proteins) are reflecting or driving metabolic impairments remain often unexplored. Thus, it is essential to understand the role of these altered molecules in the development of insulin resistance to develop new therapeutic avenues against Type 2 diabetes. In this context, skeletal muscle and, particularly, mitochondria, play a pivotal role in the systemic metabolic impairments that characterize Type 2 diabetes, such as hyperglycemia. David Rizo-Roca’s research aims at identifying metabolites and proteins involved in the development or exacerbation of systemic and skeletal muscle metabolic impairments in the Type 2 diabetes.
Teaching
- - Lecturer. Karolinska Institutet, Sweden (2023-present). Physiology course in the Bachelor's Programme in Biomedicine.
- Lecturer. Karolinska Institutet, Sweden (2022-present). Physiological experimental approaches course in the Master's Programme in Translational Physiology and Pharmacology .
- Adjunct Lecturer. Universitat de Barcelona, Spain (2014-2016). Physiology-related seminars and courses in the Bachelor's Programmes in Biology, Biochemistry, Biotechnology, Biomedicine, and Environmental Sciences - and in the Master's Programmes in Integrative Physiology and Biomedical Engineering.
Articles
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(768):eado3022
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347
- Article: NATURE METABOLISM. 2024;6(7):1329-1346
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023;53(11):e14069
- Article: DIABETES. 2022;71(4):624-636
- Article: NATURE METABOLISM. 2022;4(2):190-202
- Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2022;19(1):498
- Article: DIABETOLOGIA. 2021;64(9):2077-2091
- Article: CIRCULATION: HEART FAILURE. 2020;13(11):e006170
- Article: BEHAVIOURAL BRAIN RESEARCH. 2020;379:112358
- Article: MITOCHONDRION. 2019;47:103-113
- Article: AQUACULTURE. 2019;501:397-403
- Article: PLOS ONE. 2019;14(7):e0219167
- Article: FRONTIERS IN PHYSIOLOGY. 2019;10:593
- Article: HIGH ALTITUDE MEDICINE AND BIOLOGY. 2018;19(3):278-285
- Article: FRONTIERS IN PHYSIOLOGY. 2018;9:481
- Article: AMERICAN JOURNAL OF SPORTS MEDICINE. 2017;45(9):2131-2141
- Article: APPLIED PHYSIOLOGY, NUTRITION AND METABOLISM. 2017;42(7):683-693
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2017;122(3):580-592
- Article: CURRENT STEM CELL RESEARCH AND THERAPY. 2016;11(1):66-71
- Journal article: EUROPEAN JOURNAL OF HISTOCHEMISTRY. 2015;59(4):2544
- Article: NEUROSCIENCE. 2015;301:480-495
- Article: LIFE SCIENCES. 2015;135:124-130
- Article: CLINICAL NUTRITION. 2015;34(2):241-247
- Article: CURRENT STEM CELL RESEARCH AND THERAPY. 2015;10(2):132-139
- Article: EUROPEAN JOURNAL OF HISTOCHEMISTRY. 2015;59(4):310-316
- Article: MITOCHONDRION. 2015;20:22-33
- Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2014;54:163-173
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2014;44(7):668-677
- Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;173(1):40-45
- Article: MITOCHONDRION. 2014;15:40-51
- Article: RESPIRATORY PHYSIOLOGY AND NEUROBIOLOGY. 2014;192:112-117
- Show more
All other publications
- Book chapter: MITOCHONDRIAL BIOLOGY AND EXPERIMENTAL THERAPEUTICS. 2018;p. 379-406
Grants
- Role of creatine on skeletal muscle metabolism, insulin sensitivity and whole-body energy homeostasisEFSD/Lilly Young Investigator Research Award Programme1 October 2022 - 30 September 2024