Christopher Barker

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: BIOMOLECULES. 2023;13(6):885

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Yu J; Leibiger B; Yang S-N; Shears SBB; Leibiger IBB; Berggren P-O; Barker CJJ
Article: DIABETES. 2021;70(1):111-118

XPR1 Mediates the Pancreatic β-Cell Phosphate Flush

Barker CJ; Tessaro FHG; Ferreira SDS; Simas R; Ayala TS; Kohler M; Rajasekaran SS; Martins JO; Dare E; Berggren P-O
Article: CELLULAR SIGNALLING. 2019;58:131-136

Inositol pyrophosphates and Akt/PKB: Is the pancreatic β-cell the exception to the rule?

Kim J; Dare E; Rajasekaran SS; Ryu SH; Berggren P-O; Barker CJ
Article: CELLULAR SIGNALLING. 2018;46:120-128

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells

Rajasekaran SS; Kim J; Gaboardi G-C; Gromada J; Shears SB; dos Santos KT; Nolasco EL; Ferreira SDS; Illies C; Kohler M; Gu C; Ryu SH; Martins JO; Dare E; Barker CJ; Berggren P-O
Article: CELLULAR SIGNALLING. 2018;42:127-133

Protein kinase- and lipase inhibitors of inositide metabolism deplete IP₇ indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity

Rajasekaran SS; Illies C; Shears SB; Wang H; Ayala TS; Martins JO; Dare E; Berggren P-O; Barker CJ
Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2010;8(12):2850-2858

Conformational analysis of the natural iron chelator myo-inositol 1,2,3-trisphosphate using a pyrene-based fluorescent mimic

Mansell D; Rattray N; Etchells LL; Schwalbe CH; Blake AJ; Torres J; Kremer C; Bichenkova EV; Barker CJ; Freeman S
Article: FASEB JOURNAL. 2010;24(6):1824-1837

Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion

Leibiger B; Moede T; Uhles S; Barker CJ; Creveaux M; Domin J; Berggren P-O; Leibiger IB
Article: METHODS IN MOLECULAR BIOLOGY. 2010;645:123-131

Diphosphosinositol polyphosphates and energy metabolism: assay for ATP/ADP ratio.

Nagel A; Barker CJ; Berggren P-O; Illies C
Article: METHODS IN MOLECULAR BIOLOGY. 2010;645:21-46

HPLC separation of inositol polyphosphates.

Barker CJ; Illies C; Berggren P-O
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2009;14(1):51-59

"Chelatable iron pool": inositol 1,2,3-trisphosphate fulfils the conditions required to be a safe cellular iron ligand

Veiga N; Torres J; Mansell D; Freeman S; Dominguez S; Barker CJ; Diaz A; Kremer C
Article: CHEMICAL COMMUNICATIONS. 2008;(41):5161-5163

Fluorescent probe: complexation of Fe³⁺ with the myo-inositol 1,2,3-trisphosphate motif

Mansell D; Rattray N; Etchells LL; Schwalbe CH; Blake AJ; Bichenkova EV; Bryce RA; Barker CJ; Diaz A; Kremer C; Freeman S
Article: SCIENCE. 2007;318(5854):1299-1302

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic β cells

Illies C; Gromada J; Fiume R; Leibiger B; Yu J; Juhl K; Yang S-N; Barma DK; Falck JR; Saiardi A; Barker CJ; Berggren P-O
Article: MOLECULAR ENDOCRINOLOGY. 2007;21(11):2775-2784

An autocrine insulin feedback loop maintains pancreatic β-cell 3-phosphorylated inositol lipids

Yu J; Berggren P-O; Barker CJ
Article: CELL. 2004;119(2):273-284

Removal of Ca²⁺ channel β₃ Subunit enhances Ca²⁺ oscillation frequency and insulin exocytosis

Berggren PO; Yang SN; Murakami M; Efanov AM; Uhles S; Köhler M; Moede T; Fernström A; Appelskog LB; Aspinwall CA; Zaitsev SV; Larsson O; de Vargas LM; Fecher-Trost C; Weissgerber P; Ludwig A; Leibiger B; Juntti-Berggren L; Barker CJ; Gromada J; Freichel M; Leibiger IB; Flockerzi V
Article: BIOCHEMICAL JOURNAL. 2004;380(Pt 2):465-473

Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle.

Barker CJ; Wright J; Hughes PJ; Kirk CJ; Michell RH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(47):46210-46218

Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca²⁺ concentration

Yu J; Leibiger B; Yang SN; Caffery JJ; Shears SB; Leibiger IB; Barker CJ; Berggren PO
Article: DIABETES. 2000;49(9):1409-1412

Phosphatidylinositol 4,5-bisphosphate and ATP-sensitive potassium channel regulation - A word of caution

Larsson O; Barker CJ; Berggren PO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3242-3247

G protein-coupled receptors regulate Na⁺,K⁺-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin

Ogimoto G; Yudowski GA; Barker CJ; Köhler M; Katz AI; Féraille E; Pedemonte CH; Berggren PO; Bertorello AM
Article: SCIENCE. 1997;278(5337):471-474

Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate

Larsson O; Barker CJ; Sjoholm A; Carlqvist H; Michell RH; Bertorello A; Nilsson T; Honkanen RE; Mayr GW; Zwiller J; Berggren PO
Article: CARBOHYDRATE RESEARCH. 1996;282(1):81-99

Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and (+/-)-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates.

Spiers ID; Barker CJ; Chung SK; Chang YT; Freeman S; Gardiner JM; Hirst PH; Lambert PA; Michell RH; Poyner DR; Schwalbe CH; Smith AW; Solomons KR
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1995;23(2):169S

Inositol 1,2,3-trisphosphate is a product of InsP6 dephosphorylation in WRK-1 rat mammary epithelial cells and exhibits transient concentration changes during the cell cycle.

Barker CJ; Wright J; Kirk CJ; Michell RH
Article: BIOCHEMICAL JOURNAL. 1995;306(Pt 2):557-564

INOSITOL 1,2,3-TRISPHOSPHATE AND INOSITOL 1,2-BISPHOSPHATE AND/OR 2,3-BISPHOSPHATE ARE NORMAL CONSTITUENTS OF MAMMALIAN-CELLS

BARKER CJ; FRENCH PJ; MOORE AJ; NILSSON T; BERGGREN PO; BUNCE CM; KIRK CJ; MICHELL RH
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Review: ADVANCES IN BIOLOGICAL REGULATION. 2023;87:100919

Novel aspects of intra-islet communication: Primary cilia and filopodia

Moruzzi N; Leibiger B; Barker CJ; Leibiger IB; Berggren P-O
Corrigendum: CELLULAR SIGNALLING. 2019;53:415

Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells (vol 46, pg 120, 2018)

Rajasekaran SS; Kim J; Gaboardi G-C; Gromada J; Shears SB; dos Santos KT; Nolasco EL; Ferreira SDS; Illies C; Kohler M; Gu C; Ryu SH; Martins JO; Dare E; Barker CJ; Berggren P-O
Review: ADVANCES IN BIOLOGICAL REGULATION. 2015;57:112-119

β-Cell Ca(2+) dynamics and function are compromised in aging.

Barker CJ; Li L; Köhler M; Berggren P-O
Review: PHARMACOLOGICAL REVIEWS. 2013;65(2):641-669

New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β-Cell

Barker CJ; Berggren P-O
Review: ADVANCES IN BIOLOGICAL REGULATION. 2013;53(1):156-163

The pancreatic islet as a signaling hub.

Barker CJ; Leibiger IB; Berggren P-O
Review: ADVANCES IN BIOLOGICAL REGULATION. 2012;52(3):361-368

The pancreatic beta cell as a paradigm for advances in inositide research.

Barker CJ; Berggren P-O
Review: METHODS IN MOLECULAR BIOLOGY. 2010;645:1-19

The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells.

Barker CJ; Berggren P-O
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(24):3851-3871

Inositol pyrophosphates: structure, enzymology and function

Barker CJ; Illies C; Gaboardi GC; Berggren P-O
Review: ADVANCES IN ENZYME REGULATION. 2009;49(1):168-173

Diphosphoinositol pentakisphosphate as a novel mediator of insulin exocytosis.

Barker CJ; Illies C; Fiume R; Gaboardi GC; Yu J; Berggren P-O
Review: ADVANCES IN ENZYME REGULATION. 2008;48:276-294

A key role for phosphorylated inositol compounds in pancreatic beta-cell stimulus-secretion coupling.

Berggren P-O; Barker CJ
Review: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2002;283(6):E1113-E1122

Phosphorylated inositol compounds in β-cell stimulus-response coupling

Barker CJ; Leibiger IB; Leibiger B; Berggren PO
Published conference paper: ANTICANCER RESEARCH. 1999;19(5A):3737-3741

Inositol hexakisphosphate and β-cell stimulus-secretion coupling

Barker CJ; Berggren PO

Anställningar

Senior Forskningsspecialist, Molekylär medicin och kirurgi, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Cellbiologi, Karolinska Institutet, 2004

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