Cecilia Williams

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Hormonsignalering och icke-kodande RNA i cancer
Cecilia Williams leder en grupp på KI som delas med hennes labb på KTH och SciLifeLab. Hon doktorerade inom applicering av DNA-sekvenseringsteknologier för cancer vid KTH, gjorde postdoc inom transkriptom och stamceller, och kom som forskare till Karolinska Institutet 2005. 2009 började hon på Center of Nuclear Receptors and Cell Signaling vid University of Houston som biträdande lektor och fick tjänst som lektor där 2015. Hennes huvudsakliga verksamhet på BioNut är inriktad på att förstå hormonell signalering och rollen av icke-kodande RNA i cancer (fokus östrogenreceptorer), och innefattar handledning av doktorander.

Utbildning
1994 M.S. (Civ. Ing.) i kemiteknik med inriktning bioteknik, Kungliga Tekniska Högskolan, Stockholm
2002 Ph.D. Bioteknik, Kungliga Tekniska Högskolan. /Molecular Archaeology of Cancer - Analys av den mänskliga p53-tumörsuppressorgenen.

Utvalda publikationer

Article: BMC BIOLOGY. 2023;21(1):277
Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
Birgersson M; Indukuri R; Lindquist L; Stepanauskaite L; Luo Q; Deng Q; Archer A; Williams C
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):20
High-fat diet and estrogen modulate the gut microbiota in a sex-dependent manner in mice
Hases L; Stepanauskaite L; Birgersson M; Brusselaers N; Schuppe-Koistinen I; Archer A; Engstrand L; Williams C
Editorial comment: FRONTIERS IN ENDOCRINOLOGY. 2022;13:883229
Editorial: Role of Sex Steroids and Their Receptor in Cancers
Giovannelli P; Ramaraj P; Williams C
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2022;1390:213-225
ERβ and Inflammation.
Hases L; Archer A; Williams C
Editorial comment: ESSAYS IN BIOCHEMISTRY. 2021;65(6):847-856
Nuclear receptors: from molecular mechanisms to therapeutics
Frigo DE; Bondesson M; Williams C
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(3):692-706
Genome-wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity
Indukuri R; Jafferali MH; Song D; Damdimopoulos A; Hases L; Zhao C; Archer A; Williams C
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2021;53(11):1216-1225
Menopausal hormone therapies and risk of colorectal cancer: a Swedish matched-cohort study
Liu Q; Simin J; Debelius J; Fall K; Sadr-Azodi O; Engstrand L; Williams C; Brusselaers N
Article: CANCER CELL. 2018;33(4):690-705.e9
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
Berger AC; Korkut A; Kanchi RS; Hegde AM; Lenoir W; Liu W; Liu Y; Fan H; Shen H; Ravikumar V; Rao A; Schultz A; Li X; Sumazin P; Williams C; Mestdagh P; Gunaratne PH; Yau C; Bowlby R; Robertson AG; Tiezzi DG; Wang C; Cherniack AD; Godwin AK; Kuderer NM; Rader JS; Zuna RE; Sood AK; Lazar AJ; Ojesina AI; Adebamowo C; Adebamowo SN; Baggerly KA; Chen T-W; Chiu H-S; Lefever S; Liu L; MacKenzie K; Orsulic S; Roszik J; Shelley CS; Song Q; Vellano CP; Wentzensen N; Weinstein JN; Mills GB; Levine DA; Akbani R
Article: NATURE COMMUNICATIONS. 2017;8:15840
Insufficient antibody validation challenges oestrogen receptor beta research
Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramstrom M; Soderberg O; Williams C; Asplund A

Artiklar

Journal article: NATURE PROTOCOLS. 2024;:1-2
YCharOS protocol for antibody validation.
Monteiro FL; Voskuil JLA; Williams C
Article: COMMUNICATIONS BIOLOGY. 2024;7(1):1595
Spatial profiling of the mouse colonic immune landscape associated with colitis and sex
Holm M; Stepanauskaite L; Backstrom A; Birgersson M; Socciarelli F; Archer A; Stadler C; Williams C
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2024;242:106526
Estrogen receptor beta expression and role in cancers
Monteiro FL; Stepanauskaite L; Archer A; Williams C
Article: ENVIRONMENT INTERNATIONAL. 2024;190:108937
Development and implementation of assays to monitor human adenovirus F40/41 in wastewater: Trends preceding, during, and following the non-A-to-E hepatitis outbreak in Stockholm
Perez-Zabaleta M; Williams C; Cetecioglu Z
Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis
Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Sondergaard JN; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-Andre M; Petersson C; Hagstrom H; Lauschke VM; Archer A; Williams C; Kutter C
Article: TOXICOLOGICAL SCIENCES. 2023;193(2):119-130
Triazole fungicides induce adipogenesis and repress osteoblastogenesis in zebrafish
Thrikawala S; Mesmar F; Bhattacharya B; Muhsen M; Mukhopadhyay S; Flores S; Upadhyay S; Vergara L; Gustafsson J-A; Williams C; Bondesson M
Article: PROTEIN & CELL. 2023;14(2):123-136
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation
Cheng Y; Lu X; Li F; Chen Z; Zhang Y; Han Q; Zeng Q; Wu T; Li Z; Lu S; Williams C; Xia W
Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2023;20(5):4181
Statistical Analysis of SARS-CoV-2 Using Wastewater-Based Data of Stockholm, Sweden.
Chekkala A; Atasoy M; Williams C; Cetecioglu Z
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2023;858(Pt 3):160023
Long-term SARS-CoV-2 surveillance in the wastewater of Stockholm: What lessons can be learned from the Swedish perspective?
Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
Article: CANCERS. 2022;14(24):6029
SETD7 Expression Is Associated with Breast Cancer Survival Outcomes for Specific Molecular Subtypes: A Systematic Analysis of Publicly Available Datasets
Monteiro FL; Stepanauskaite L; Williams C; Helguero LAA
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(18):10408
Colitis Induces Sex-Specific Intestinal Transcriptomic Responses in Mice
Hases L; Birgersson M; Indukuri R; Archer A; Williams C
Journal article: ANNALS OF ONCOLOGY. 2022;33:s640
223P Gene expression profiles in endocrine-resistant breast cancer
Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
Article: CANCERS. 2022;14(13):3098
Estrogen Receptor β (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens
Huang D; Huang Z; Indukuri R; Revanna CB; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
Article: CANCERS. 2022;14(6):1414
A Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer
Monteiro FL; Williams C; Helguero LA
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:203-221
An Optimized ChIP-Seq Protocol to Determine Chromatin Binding of Estrogen Receptor Beta.
Indukuri R; Damdimopoulos A; Williams C
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:1-23
Antibody Validation for Estrogen Receptor Beta.
Birgersson M; Katona B; Lindskog C; Pontén F; Williams C
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:930227
ERα and ERβ Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions
Song D; He H; Indukuri R; Huang Z; Stepanauskaite L; Sinha I; Haldosen L-A; Zhao C; Williams C
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:313-343
Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells.
Archer A; Kutter C; Williams C
Article: ACTA ONCOLOGICA. 2021;60(7):881-887
Prediagnostic use of estrogen-only therapy is associated with improved colorectal cancer survival in menopausal women: a Swedish population-based cohort study
Simin J; Liu Q; Wang X; Fall K; Williams C; Callens S; Engstrand L; Brusselaers N
Article: CANCER LETTERS. 2021;506:23-34
Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor
Song D; He H; Sinha I; Hases L; Yan F; Archer A; Haldosen L-A; Zhao C; Williams C
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2021;755(Pt 1):142939
Benchmarking virus concentration methods for quantification of SARS-CoV-2 in raw wastewater
Jafferali MH; Khatami K; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354
The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers
Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
Article: FRONTIERS IN ENDOCRINOLOGY. 2021;12:650625
Estrogen Receptor Beta Influences the Inflammatory p65 Cistrome in Colon Cancer Cells
Indukuri R; Hases L; Archer A; Williams C
Article: CANCER LETTERS. 2020;492:54-62
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Article: SCIENTIFIC REPORTS. 2020;10(1):16160
High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner
Hases L; Archer A; Indukuri R; Birgersson M; Savva C; Korach-Andr M; Williams C
Article: PEERJ. 2020;8:e9434
Comparison of serum exosome isolation methods on co-precipitated free microRNAs
Cheng Y; Qu X; Dong Z; Zeng Q; Ma X; Jia Y; Li R; Jiang X; Williams C; Wang T; Xia W
Article: MABS. 2020;12(1):1794421
The Antibody Society's antibody validation webinar series
Voskuil JLA; Bandrowski A; Begley CG; Bradbury ARM; Chalmers AD; Gomes AV; Hardcastle T; Lund-Johansen F; Plueckthun A; Roncador G; Solache A; Taussig MJ; Trimmer JS; Williams C; Goodman SL
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(12):22220-22233
A miR-206 regulated gene landscape enhances mammary epithelial differentiation
Wang J; Aydogdu E; Mukhopadhyay S; Helguero LA; Williams C
Article: CANCER MEDICINE. 2019;8(18):7705-7719
Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling
Mesmar F; Dai B; Ibrahim A; Hases L; Jafferali MH; Augustine JJ; DiLorenzo S; Kang Y; Zhao Y; Wang J; Kim M; Lin C-Y; Berkenstam A; Fleming J; Williams C
Article: BMC CANCER. 2019;19(1):684
Sexual dimorphism in the incidence of human cancers
Zheng D; Trynda J; Williams C; Vold JA; Nguyen JH; Harnois DM; Bagaria SP; McLaughlin SA; Li Z
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(12):3086-3098
Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity
Ibrahim A; Hugerth LW; Hases L; Saxena A; Seifert M; Thomas Q; Gustafsson J-A; Engstrand L; Williams C
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1966:79-99
Antibody Validation Strategy for Nuclear Receptors.
Katona B; Ibrahim A; Sundberg M; Williams C
Journal article: CELL SYSTEMS. 2018;7(4):422-437.e7
A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Korkut A; Zaidi S; Kanchi RS; Rao S; Gough NR; Schultz A; Li X; Lorenzi PL; Berger AC; Robertson G; Kwong LN; Datto M; Roszik J; Ling S; Ravikumar V; Manyam G; Rao A; Shelley S; Liu Y; Ju Z; Hansel D; de Velasco G; Pennathur A; Andersen JB; O'Rourke CJ; Ohshiro K; Jogunoori W; Bao-Ngoc N; Li S; Osmanbeyoglu HU; Ajani JA; Mani SA; Houseman A; Wiznerowicz M; Chen J; Gu S; Ma W; Zhang J; Tong P; Cherniack AD; Deng C; Resar L; Weinstein JN; Mishra L; Akbani R
Article: ONCOTARGET. 2018;9(28):19730-19744
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.
Danielsson F; Fasterius E; Sullivan D; Hases L; Sanli K; Zhang C; Mardinoglu A; Al-Khalili C; Huss M; Uhlén M; Williams C; Lundberg E
Journal article: CANCER RESEARCH. 2017;77:4401
Role of estrogen signaling in colon microenvironment during obesity
Archer A; Pettersson L; Gonzalez-Granillo M; Savva C; Korach-Andre M; Williams C
Journal article: CANCER RESEARCH. 2017;77:2819
Intestinal estrogen receptor beta attenuates colon cancer signaling pathways in vivo
Pettersson L; Saxena A; Vu T; Gustafsson J-A; Archer A; Williams C
Article: CANCER LETTERS. 2017;396:42-52
The histone H2A isoform Hist2h2ac is a novel regulator of proliferation and epithelial-mesenchymal transition in mammary epithelial and in breast cancer cells
Monteiro FL; Vitorino R; Wang J; Cardoso H; Laranjeira H; Simoes J; Caldas M; Henrique R; Amado F; Williams C; Jeronimo C; Helguero LA
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):djw236-14
Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells
Ma R; Karthik G-M; Lovrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
Article: PLOS ONE. 2017;12(2):e0172832
Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant
Simon M; Mesmar F; Helguero L; Williams C
Article: ONCOTARGET. 2016;7(27):42159-42171
Estrogen receptor beta reduces colon cancer metastasis through a novel miR-205-PROX1 mechanism
Trang N-V; Wang J; Mesmar F; Mukhopadhyay S; Saxena A; McCollum CW; Gustafsson J-A; Bondesson M; Williams C
Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2016;57(6):2689-2698
Vitamin D Induces Global Gene Transcription in Human Corneal Epithelial Cells: Implications for Corneal Inflammation
Reins RY; Mesmar F; Williams C; McDermott AM
Article: ONCOGENE. 2016;35(15):1955-1964
RING finger protein 31 promotes p53 degradation in breast cancer cells
Zhu J; Zhao C; Zhuang T; Jonsson P; Sinha I; Williams C; Stromblad S; Dahlman-Wright K
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1366:373-393
Expression Profiles of Estrogen-Regulated MicroRNAs in Breast Cancer Cells.
Katchy A; Williams C
Article: MOLECULAR ENDOCRINOLOGY. 2015;29(11):1634-1645
Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer
Jonsson P; Coarfa C; Mesmar F; Raz T; Rajapakshe K; Thompson JF; Gunaratne PH; Williams C
Article: CARCINOGENESIS. 2015;36(9):1051-1060
miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene
Tsouko E; Wang J; Frigo DE; Aydogdu E; Williams C
Article: PLOS ONE. 2015;10(5):e0128239
Estrogen Receptor β2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1α in Prostate Cancer
Dey P; Velazquez-Villegas LA; Faria M; Turner A; Jonsson P; Webb P; Williams C; Gustafsson J-A; Stroem AM
Article: MOLECULAR ONCOLOGY. 2014;8(8):1690-1702
miR-206 inhibits cell migration through direct targeting of the actin-binding protein Coronin 1C in triple-negative breast cancer
Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Article: THE FASEB JOURNAL. 2014;28(10):4247-4264
Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival
Doria ML; Ribeiro AS; Wang J; Cotrim CZ; Domingues P; Williams C; Domingues MR; Helguero LA
Article: ONCOGENE. 2014;33(34):4340-4351
The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation
Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Stroemblad S; Treuter E; Dahlman-Wright K
Article: CANCER RESEARCH. 2014;74(14):3983-3994
Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
Article: ENDOCRINE-RELATED CANCER. 2014;21(2):143-160
Support of a bi-faceted role of estrogen receptor β (ERβ) in ERα-positive breast cancer cells
Jonsson P; Katchy A; Williams C
Article: TOXICOLOGICAL SCIENCES. 2014;138(1):21-35
Coexposure to Phytoestrogens and Bisphenol A Mimics Estrogenic Effects in an Additive Manner
Katchy A; Pinto C; Jonsson P; Trang N-V; Pandelova M; Riu A; Schramm K-W; Samarov D; Gustafsson J-A; Bondesson M; Williams C
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(84):e51285
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Katchy A; Williams C
Article: ENDOCR DISRUPTORS (AUSTIN). 2014;2(1):e29088
Gestational bisphenol A exposure and testis development.
Williams C; Bondesson M; Krementsov DN; Teuscher C
Article: TOXICOLOGICAL SCIENCES. 2013;135(1):91-102
Studies in Experimental Autoimmune Encephalomyelitis Do Not Support Developmental Bisphenol A Exposure as an Environmental Factor in Increasing Multiple Sclerosis Risk
Krementsov DN; Katchy A; Case LK; Carr FE; Davis B; Williams C; Teuscher C
Article: CARCINOGENESIS. 2013;34(7):1431-1441
Estrogen receptor expression induces changes in the microRNA pool in human colon cancer cells
Edvardsson K; Trang N-V; Kalasekar SM; Ponten F; Gustafsson J-A; Williams C
Article: BREAST CANCER RESEARCH. 2013;15(3):R51
Liver x receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
Trang N-V; Vedin L-L; Liu K; Jonsson P; Lin JZ; Candelaria NR; Candelaria LP; Addanki S; Williams C; Gustafsson J-A; Steffensen KR; Lin C-Y
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1991-2003
Estrogen Receptors β1 and β2 Have Opposing Roles in Regulating Proliferation and Bone Metastasis Genes in the Prostate Cancer Cell Line PC3
Dey P; Jonsson P; Hartman J; Williams C; Stroem A; Gustafsson J-A
Article: CARCINOGENESIS. 2012;33(9):1684-1691
Interplay between AP-1 and estrogen receptor in regulating gene expression and proliferation networks in breast cancer cells
Dahlman-Wright K; Qiao Y; Jonsson P; Gustafsson J-A; Williams C; Zhao C
Article: CARCINOGENESIS. 2012;33(8):1502-1511
MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer
Aydogdu E; Katchy A; Tsouko E; Lin C-Y; Haldosen L-A; Helguero L; Williams C
Journal article: CANCER RESEARCH. 2012;72(8_Supplement):547
Abstract 547: Mapping of estrogen receptor-dependent and independent signaling pathways for xeno- and phytoestrogens
Katchy AC; Pinto C; Bondesson M; Williams C
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2012;128(3-5):145-153
Estradiol-activated estrogen receptor α does not regulate mature microRNAs in T47D breast cancer cells
Katchy A; Edvardsson K; Aydogdu E; Williams C
Article: PLOS ONE. 2012;7(3):e32080
Knockdown of SF-1 and RNF31 Affects Components of Steroidogenesis, TGFβ, and Wnt/β-catenin Signaling in Adrenocortical Carcinoma Cells
Ehrlund A; Jonsson P; Vedin L-L; Williams C; Gustafsson J-A; Treuter E
Journal article: CANCER RESEARCH. 2011;71(24_Supplement):p1-02-04-p1-02-04
P1-02-04: Estrogen Receptor beta Inhibits Breast Cancer EMT by Regulating the Expression of miR-200.
Thomas C; Gayani R; Nikolos F; Hao R; Katchy A; McCollum C; Williams C; Bondesson M; Krishnamurthy S; Esteva F; Gustafsson J-A
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(8):1326-1336
The Two-Pore Domain Potassium Channel KCNK5: Induction by Estrogen Receptor α and Role in Proliferation of Breast Cancer Cells
Alvarez-Baron CP; Jonsson P; Thomas C; Dryer SE; Williams C
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(6):969-979
Estrogen Receptor β Induces Antiinflammatory and Antitumorigenic Networks in Colon Cancer Cells
Edvardsson K; Stroem A; Jonsson P; Gustafsson J-A; Williams C
Journal article: CANCER RESEARCH. 2011;71(8_Supplement):271
Abstract 271: Rapid regulation of ion channel KCNK5 by ERα in breast cancer cell lines MCF-7 and T47D promotes cell proliferation
Alvarez-Baron CP; Jonsson P; Dryer S; Williams C
Journal article: CANCER RESEARCH. 2009;69(24_Supplement):1162
Mammary Stem Cell-Like Gene Expression and Relation to Cancer.
Williams C; Helguero L; Edvardsson K; Haldosén L; Gustafsson J
Article: CANCER RESEARCH. 2009;69(15):6100-6106
Tumor Repressive Functions of Estrogen Receptor β in SW480 Colon Cancer Cells
Hartman J; Edvardsson K; Lindberg K; Zhao C; Williams C; Strom A; Gustafsson J-A
Article: BREAST CANCER RESEARCH. 2009;11(3):R26
Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression
Williams C; Helguero L; Edvardsson K; Haldosen L-A; Gustafsson J-A
Article: ONCOGENE. 2008;27(7):1019-1032
A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells
Williams C; Edvardsson K; Lewandowski SA; Stroem A; Gustafsson J-A
Article: BMC DEVELOPMENTAL BIOLOGY. 2007;7:129
Gene array identification of Ipf1/Pdx1^-/- regulated genes in pancreatic progenitor cells
Svensson P; Williams C; Lundeberg J; Ryden P; Bergqvist I; Edlund H
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812
Catalog of gene expression in adult neural stem cells and their in vivo microenvironment
Williams C; Wirta V; Meletis K; Wikstrom L; Carlsson L; Frisen J; Lundeberg J
Article: BMC GENOMICS. 2006;7:75
Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression
Richter K; Wirta V; Dahl L; Bruce S; Lundeberg J; Carlsson L; Williams C
Article: PHOTODERMATOLOGY PHOTOIMMUNOLOGY AND PHOTOMEDICINE. 2002;18(6):287-293
The mutagenic effect of ultraviolet-A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes
Persson Å; Edström DW; Bäckvall H; Lundeberg J; Pontén F; Ros AM; Williams C
Article: ONCOGENE. 2001;20(53):7770-7778
PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer
Ling G; Ahmadian A; Persson Å; Undén AB; Afink G; Williams C; Uhlén M; Toftgård R; Lundeberg J; Pontén F
Article: ANALYTICAL BIOCHEMISTRY. 2000;287(1):25-31
Analysis of p53 mutations in single cells obtained from histological tissue sections
Persson Å; Ling G; Williams C; Bäckvall H; Pontén J; Pontén F; Lundeberg J
Article: AMERICAN JOURNAL OF PATHOLOGY. 1999;155(5):1467-1471
A high frequency of sequence alterations is due to formalin fixation of archival specimens
Williams C; Pontén F; Moberg C; Söderkvist P; Uhlén M; Pontén J; Sitbon G; Lundeberg J
Article: GENE. 1999;235(1-2):103-109
Context-dependent Taq-polymerase-mediated nucleotide alterations, as revealed by direct sequencing of the ZNF189 gene:: implications for mutation detections
Odeberg J; Ahmadian A; Williams C; Uhlén M; Pontén F; Lundeberg J
Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 1999;8(5):433-438
p53 mutations in lung cancer associated with residential radon exposure
Yngveson A; Williams C; Hjerpe A; Lundeberg J; Söderkvist P; Pershagen G
Article: ONCOGENE. 1998;17(14):1837-1843
Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma
Ahmadian A; Ren ZP; Williams C; Pontén F; Odeberg J; Pontén J; Uhlén M; Lundeberg J
Article: GENOMICS. 1998;50(2):213-221
Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31
Odeberg J; Rosok O; Gudmundsson GH; Ahmadian A; Roshani L; Williams C; Larsson C; Pontén F; Uhlén M; Åsheim HC; Lundeberg J
Article: CANCER RESEARCH. 1998;58(11):2449-2455
Clones of normal keratinocytes and a variety of simultaneously present epidermal neoplastic lesions contain a multitude of p53 gene mutations in a xeroderma pigmentosum patient
Williams C; Pontén F; Ahmadian A; Ren ZP; Ling G; Rollman O; Ljung A; Jaspers NGJ; Uhlén M; Lundeberg J; Pontén J
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s145
Single-cell genetic analysis of the p%3 gene in human basal cell carcinoma(BCC)
Gao L; Ponten F; Williams C; Lundeberg J; Ponten J; Uhlen M
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s48
p53 gene mutations are common in clones of morphologically normal keratinocytes as well as in neoplastic lesions in xeroderma pigmentosum (XP)
Pontén F; Williams C; Ahmadian A; Ling G; Uhlén M; Lundeberg J; Pontén J
Article: CLINICAL CHEMISTRY. 1998;44(3):455-462
Assessment of sequence-based p53 gene analysis in human breast cancer:: messenger RNA in comparison with genomic DNA targets
Williams C; Norberg T; Ahmadian A; Pontén F; Bergh J; Inganäs M; Lundeberg J; Uhlén M
Article: MUTATION RESEARCH - FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1997;382(1-2):45-55
Genomic analysis of single cells from human basal cell cancer using laser-assisted capture microscopy
Ponten F; Williams C; Ling G; Ahmadian A; Nister M; Lundeberg J; Ponten J; Uhlen M
Article: ONCOGENE. 1997;15(9):1059-1067
Molecular pathology in basal cell cancer with p53 as a genetic marker
Ponten F; Berg C; Ahmadian A; Ren ZP; Nister M; Lundeberg J; Uhlen M; Ponten J
Article: AMERICAN JOURNAL OF PATHOLOGY. 1997;150(5):1791-1803
Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin
Ren ZP; Ahmadian A; Ponten F; Nister M; Berg C; Lundeberg J; Uhlen M; Ponten J
Journal article: MELANOMA RESEARCH. 1996;6(SUPPLEMENT 1):s53
Multiple p53 mutations are common in basal cell carcinoma
Pontén F; Berg C; Uhlén M; Pontén J
Article: CLINICAL CHEMISTRY. 1995;41(10):1461-1466
DIRECT SOLID-PHASE SEQUENCE-ANALYSIS OF THE HUMAN P53 GENE BY USE OF MULTIPLEX POLYMERASE CHAIN-REACTION AND ALPHA-THIOTRIPHOSPHATE NUCLEOTIDES
BERG C; HEDRUM A; HOLMBERG A; PONTEN F; UHLEN M; LUNDEBERG J
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Preprint: BIORXIV. 2023
Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease
Sommerauer C; Gallardo-Dodd C; Savva C; Hases L; Birgersson M; Indukuri R; Shen J; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke V; Archer A; Williams C; Kutter C
Review: ENDOCRINOLOGY. 2023;164(6):bqad063
ERβ in Granulosa Cell Tumors and Its Clinical Potential
Birgersson M; Indukuri R; Antonson P; Nalvarte I; Archer A; Williams C
Conference publication: BIOPHYSICAL JOURNAL. 2023;122(3):289A
Sensing of protein and DNA complexes using solid-state nanopores
Jain S; Birgersson M; Kipen J; Jalden J; Stemme G; Niklaus F; Raja SN; Williams C; Herland A
Preprint: MEDRXIV. 2022
New primer sets to detect recent human adenovirus F41 variants in wastewater: Is it linked to the new acute hepatitis?
Perez-Zabaleta M; Williams C; Cetecioglu Z
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S640
Gene expression profiles in endocrine-resistant breast cancer
Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-07-07-p1-07-07
Endoresist: Prognostic and predictive gene profiles in endocrine-resistant breast cancers
Schagerholm C; Robertson S; Holm B; Lindberg K; Sifakis E; Hases L; Williams C; Hartman J
Preprint: SSRN ELECTRONIC JOURNAL. 2022
Long-Term SARS-CoV-2 Surveillance in the Wastewater of Stockholm: What Lessons Can Be Learned from the Swedish Perspective?
Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
Conference publication: CANCER RESEARCH. 2020;80(16):4085
Blocking Fra-1 sensitises triple-negative breast cancer to olaparib
Song D; He H; Sinha I; Pettersson L; Yan F; Haldosen L-A; Zhao C; Williams C
Conference publication: CANCER RESEARCH. 2020;80(16):2081
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Preprint: BIORXIV. 2020
High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogens
Hases L; Archer A; Indukuri R; Birgersson M; Savva C; Korach-André M; Williams C
Preprint: RESEARCH SQUARE. 2019
Comparison of Serum Exosome Isolation Methods on Co-precipitated Free MicroRNAs
Cheng Y; Qu X; Dong Z; Zeng Q; Ma X; Jia Y; Li R; Jiang X; Williams C; Wang T; Xia W
Corrigendum: ONCOGENE. 2019;38(2):299-300
The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation (vol 33, pg 4340, 2018)
Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Stromblad S; Treuter E; Dahlman-Wright K
Review: CANCER LETTERS. 2018;438:24-31
Regulation of sex hormone receptors in sexual dimorphism of human cancers
Zheng D; Williams C; Vold JA; Nguyen JH; Harnois DM; Bagaria SP; McLaughlin SA; Li Z
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2018;29(26)
Deep immunological profiling of the murine brain and spleen after high fat diet by CODEX multiplexed imaging.
Gnann C; Casals AM; Xu H; Kheder S; Archer A; Mulder J; Mitsios N; Williams C; Lundberg E; Ayoglu B
Conference publication: CANCER RESEARCH. 2017;77:3614
Antibody validation revises estrogen receptor beta research
Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramstrom M; Soderberg O; Williams C; Asplund A
Conference publication: CANCER RESEARCH. 2017;77:5493
The cistrome of estrogen receptor beta in colorectal cancer cells
Indukuri R; Wang J; Mesmar F; Williams C
Conference publication: CANCER RESEARCH. 2017;77:4920
Inflammation and estrogen receptor beta modulate bacterial diversity of the gut
Ibrahim AF; Thomas Q; Saxena A; Williams C
Review: CANCER LETTERS. 2016;372(1):48-56
Estrogen receptor beta as target for colorectal cancer prevention
Williams C; DiLeo A; Niv Y; Gustafsson J-A
Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2016;57(12)
Microarray Analysis of Vitamin D Treated Human Corneal Epithelial Cells
Reins RY; Mesmar F; Williams C; McDermott AM
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1849(2):142-151
Estrogen receptor signaling during vertebrate development
Bondesson M; Hao R; Lin C-Y; Williams C; Gustafsson J-A
Conference publication: CANCER RESEARCH. 2013;73:p4-07-12-p4-07-12
miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer
Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Review: ECANCERMEDICALSCIENCE. 2013;7:370
Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.
Williams C; Lin C-Y
Conference publication: CANCER RESEARCH. 2013;73(8):4915
Estrogen receptor β is expressed within breast cancer cells with stem cell like capacity and confers endocrine sensitivity
Ma R; Govindasamy KM; Rosin G; Gustafsson J; Katchy A; Lindstrom L; Hilliges C; Viberg L; Blomqvist L; Frisell J; Williams C; Fredriksson I; Bergh J; Hartman J
Conference publication: CANCER RESEARCH. 2012;72:1207
Opposite effects on proliferation and bone metastasis genes by Estrogen Receptor B1 and Estrogen Receptor B2 in the prostate cancer cell line PC3
Dey P; Jonsson P; Hartman J; Williams C; Gustafsson J-A; Strom A
Conference publication: CANCER RESEARCH. 2011;71:p3-03-08-p3-03-08
microRNAs in Mammary Stem-Like Cells and Triple-Negative Breast Cancer; Conserved Functions and Treatment Potential.
Williams C; Aydogdu E; Katchy A; Lin C-Y; Baldosen L-A; Helguero L
Conference publication: CANCER RESEARCH. 2010;70:2076
Mammary stem cell-like miRNA expression and relation to cancer
Aydogdu E; Helguero L; Haldosen L-A; Williams CM
Conference publication: CANCER RESEARCH. 2010;70:2921
Antitumorigenic effects by ERβ in three different human colorectal cancer cell lines
Edvardsson K; Strom A; Gustafsson J-A; Williams C
Conference publication: CANCER RESEARCH. 2009;69(24):589S-590S
Mammary Stem Cell-Like Gene Expression and Relation to Cancer
Williams C; Helguero L; Edvardsson K; Haldosen L-A; Gustafsson J-A
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S233
Estrogen receptors in seminal vesicle and prostate;: Do they play a role in male fertility?
Schwend T; Imamov O; Williams C; Gustafsson J-A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(3):815
The mutagenic effects of long-wave ultraviolet A in human skin;: Studied by analysing the p53 gene in single cells
Edström DW; Persson Å; Bäckvall H; Lundeberg J; Pontén F; Ros AM; Williams C
Conference publication: EPIDEMIOLOGY. 1999;10(4):S83
Radon and p53 mutations in lung cancer.
Yngveson A; Williams C; Hjerpe A; Lundeberg J; Söderkvist P; Pershagen G
Book chapter: SKIN CANCER AND UV RADIATION. 1997;p. 709-714
Multiple p53 Mutations are Common in Basal Cell Carcinoma
Ponten F; Berg C; Uhlen M; Ponten J
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Forskningsbidrag

How estrogen receptors of the colon create a microenvironment that suppress carcinogenesis - for cancer prevention and treatment
Swedish Research Council
1 January 2023 - 31 December 2026
QuantumSense - Quantum Tunneling Sensing of Biomolecules for High-Throughput Decoding of DNA and RNA
Swedish Research Council
1 December 2018 - 30 November 2024
Estrogen-regulated lncRNAs as mediators of tumor-repressive functions in colon
Swedish Research Council
1 January 2018 - 31 December 2021
Utilizing large-scale genomic techniques to decipher nuclear receptor and microRNA mechanisms in cancer
VINNOVA
1 June 2014 - 28 February 2018
Elucidating the mechanism of ERbeta in colon carcinogenesis
National Cancer Institute
1 August 2013 - 31 May 2019
Epigenetic regulation in mammary stem/progenitor cells and its contribution to malignant transformation
Fundação para a Ciência e Tecnologia
15 March 2012 - 14 July 2015

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