Cecilia Williams
Principal Researcher
E-mail: cecilia.williams@ki.se
Visiting address: Blickagången 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 GUT Williams, 171 77 Stockholm
About me
- Hormone signalling and non-coding RNAs in cancer
Cecilia Williams leads a group at KI that is shared with her lab at KTH and SciLifeLab. She received her PhD training in DNA sequencing technologies and the p53 tumor suppressor gene at KTH, postdoc training in gene expression profiling techniques and stem cells, and was later a researcher at Karolinska Institutet where she studied the role of estrogen receptor beta. In 2009, she joined the Center of Nuclear Receptors and Cell Signaling at University of Houston as Assistant Professor and received a tenured Associate Professorship in 2015. Her main activities at BioNut are focused at understanding hormonal signalling and the role of non-coding RNAs in cancer, and include supervision of doctoral students.
Education
1994 M.S. (Civ. Ing.) in Chemical Engineering with specialization in Biotechnology, KTH Royal Institute of Technology, Stockholm
2002 Ph.D. Biotechnology, KTH Royal Institute of Technology. /Molecular Archaeology of Cancer - Analysis of the Human p53 Tumor Suppressor Gene.
Research
- Hormone signalling and non-coding RNAs in cancer
The Williams’ group focuses on understanding key molecular mechanisms in cancer, applying a combination of large-scale genomic approaches, focused mechanistic experiments and animal studies. The goal is to understand critical pathways so that we can define biomarkers of their activity and suggest better cancer treatments and preventive approaches. The hormone estrogen increases the risk of breast cancer, but can simultaneously protect against colorectal cancer. It is not understood exactly how, but if we can achieve a detailed knowledge of this mechanism, we could design approaches that can protect against colon cancer while not promoting breast cancer.
Estrogenic signaling is mediated by the estrogen receptors, ERalpha, ERbeta and GPER1. ERalpha and ERbeta are ligand-activated nuclear receptors and as such excellent therapeutic targets. Our research focuses on understanding estrogen-induced pathways in breast and colon cancer, and the impact that environmental or dietary estrogenic exposure may have. Related to this, is the identification of molecular mechanisms involving microRNAs and long non-coding RNAs, molecules with great potential as novel biomarkers and therapeutic targets. These molecules are likely to contribute to the estrogenic effects, but this area remains to be explored. Our previous work include identification of the estrogen-regulated transcriptome, the roles of specific microRNAs in cell migration, and expression and regulations of lncRNAs, with a focus on cancer.
Teaching
Course responsible, teacher, and examiner for Clinical Applications of Biotechnology (6.0 credits, 2019-2023), Master's programme in Molecular Techniques in
Life Science (SciLifeLab)
Selected publications
- Journal article: NATURE PROTOCOLS. 2025;20(6):1389-1390Monteiro FL; Voskuil JLA; Williams C
- Article: COMMUNICATIONS BIOLOGY. 2024;7(1):1595Holm M; Stepanauskaite L; Backstrom A; Birgersson M; Socciarelli F; Archer A; Stadler C; Williams C
- Article: BMC BIOLOGY. 2023;21(1):277Birgersson M; Indukuri R; Lindquist L; Stepanauskaite L; Luo Q; Deng Q; Archer A; Williams C
- Article: COMMUNICATIONS BIOLOGY. 2023;6(1):20Hases L; Stepanauskaite L; Birgersson M; Brusselaers N; Schuppe-Koistinen I; Archer A; Engstrand L; Williams C
- Journal article: ESSAYS IN BIOCHEMISTRY. 2021;65(6):847-856Frigo DE; Bondesson M; Williams C
- Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(3):692-706Indukuri R; Jafferali MH; Song D; Damdimopoulos A; Hases L; Zhao C; Archer A; Williams C
- Article: CANCER CELL. 2018;33(4):690-705.e9Berger AC; Korkut A; Kanchi RS; Hegde AM; Lenoir W; Liu W; Liu Y; Fan H; Shen H; Ravikumar V; Rao A; Schultz A; Li X; Sumazin P; Williams C; Mestdagh P; Gunaratne PH; Yau C; Bowlby R; Robertson AG; Tiezzi DG; Wang C; Cherniack AD; Godwin AK; Kuderer NM; Rader JS; Zuna RE; Sood AK; Lazar AJ; Ojesina AI; Adebamowo C; Adebamowo SN; Baggerly KA; Chen T-W; Chiu H-S; Lefever S; Liu L; MacKenzie K; Orsulic S; Roszik J; Shelley CS; Song Q; Vellano CP; Wentzensen N; Weinstein JN; Mills GB; Levine DA; Akbani R
- Article: NATURE COMMUNICATIONS. 2017;8:15840Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramstrom M; Soderberg O; Williams C; Asplund A
Articles
- Article: CANCER LETTERS. 2025;622:217661Birgersson M; Holm M; Gallardo-Dodd CJ; Chen B; Stepanauskaite L; Hases L; Kutter C; Archer A; Williams C
- Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2024;242:106526Monteiro FL; Stepanauskaite L; Archer A; Williams C
- Article: ENVIRONMENT INTERNATIONAL. 2024;190:108937Perez-Zabaleta M; Williams C; Cetecioglu Z
- Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Sondergaard JN; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-Andre M; Petersson C; Hagstrom H; Lauschke VM; Archer A; Williams C; Kutter C
- Article: TOXICOLOGICAL SCIENCES. 2023;193(2):119-130Thrikawala S; Mesmar F; Bhattacharya B; Muhsen M; Mukhopadhyay S; Flores S; Upadhyay S; Vergara L; Gustafsson J-A; Williams C; Bondesson M
- Article: PROTEIN & CELL. 2023;14(2):123-136Cheng Y; Lu X; Li F; Chen Z; Zhang Y; Han Q; Zeng Q; Wu T; Li Z; Lu S; Williams C; Xia W
- Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2023;20(5):4181Chekkala A; Atasoy M; Williams C; Cetecioglu Z
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2023;858(Pt 3):160023Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
- Article: CANCERS. 2022;14(24):6029Monteiro FL; Stepanauskaite L; Williams C; Helguero LAA
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(18):10408Hases L; Birgersson M; Indukuri R; Archer A; Williams C
- Journal article: ANNALS OF ONCOLOGY. 2022;33:s640Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
- Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:930227Song D; He H; Indukuri R; Huang Z; Stepanauskaite L; Sinha I; Haldosen L-A; Zhao C; Williams C
- Article: CANCERS. 2022;14(13):3098Huang D; Huang Z; Indukuri R; Revanna CB; Berglund M; Guan J; Yakimchuk K; Damdimopoulos A; Williams C; Okret S
- Journal article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:883229Giovannelli P; Ramaraj P; Williams C
- Article: CANCERS. 2022;14(6):1414Monteiro FL; Williams C; Helguero LA
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:203-221Indukuri R; Damdimopoulos A; Williams C
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:313-343Archer A; Kutter C; Williams C
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:1-23Birgersson M; Katona B; Lindskog C; Pontén F; Williams C
- Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2022;1390:213-225Hases L; Archer A; Williams C
- Article: ACTA ONCOLOGICA. 2021;60(7):881-887Simin J; Liu Q; Wang X; Fall K; Williams C; Callens S; Engstrand L; Brusselaers N
- Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2021;53(11):1216-1225Liu Q; Simin J; Debelius J; Fall K; Sadr-Azodi O; Engstrand L; Williams C; Brusselaers N
- Article: CANCER LETTERS. 2021;506:23-34Song D; He H; Sinha I; Hases L; Yan F; Archer A; Haldosen L-A; Zhao C; Williams C
- Article: FRONTIERS IN ENDOCRINOLOGY. 2021;12:650625Indukuri R; Hases L; Archer A; Williams C
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2021;755(Pt 1):142939Jafferali MH; Khatami K; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
- Article: CANCER LETTERS. 2020;492:54-62Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
- Article: SCIENTIFIC REPORTS. 2020;10(1):16160Hases L; Archer A; Indukuri R; Birgersson M; Savva C; Korach-Andr M; Williams C
- Article: PEERJ. 2020;8:e9434Cheng Y; Qu X; Dong Z; Zeng Q; Ma X; Jia Y; Li R; Jiang X; Williams C; Wang T; Xia W
- Article: MABS. 2020;12(1):1794421Voskuil JLA; Bandrowski A; Begley CG; Bradbury ARM; Chalmers AD; Gomes AV; Hardcastle T; Lund-Johansen F; Pluckthun A; Roncador G; Solache A; Taussig MJ; Trimmer JS; Williams C; Goodman SL
- Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2019;234(12):22220-22233Wang J; Aydogdu E; Mukhopadhyay S; Helguero LA; Williams C
- Article: CANCER MEDICINE. 2019;8(18):7705-7719Mesmar F; Dai B; Ibrahim A; Hases L; Jafferali MH; Augustine JJ; DiLorenzo S; Kang Y; Zhao Y; Wang J; Kim M; Lin C-Y; Berkenstam A; Fleming J; Williams C
- Article: BMC CANCER. 2019;19(1):684Zheng D; Trynda J; Williams C; Vold JA; Nguyen JH; Harnois DM; Bagaria SP; McLaughlin SA; Li Z
- Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(12):3086-3098Ibrahim A; Hugerth LW; Hases L; Saxena A; Seifert M; Thomas Q; Gustafsson J-A; Engstrand L; Williams C
- Journal article: ONCOGENE. 2019;38(2):299-300Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Stromblad S; Treuter E; Dahlman-Wright K
- Article: METHODS IN MOLECULAR BIOLOGY. 2019;1966:79-99Katona B; Ibrahim A; Sundberg M; Williams C
- Journal article: CELL SYSTEMS. 2018;7(4):422-437.e7Korkut A; Zaidi S; Kanchi RS; Rao S; Gough NR; Schultz A; Li X; Lorenzi PL; Berger AC; Robertson G; Kwong LN; Datto M; Roszik J; Ling S; Ravikumar V; Manyam G; Rao A; Shelley S; Liu Y; Ju Z; Hansel D; de Velasco G; Pennathur A; Andersen JB; O'Rourke CJ; Ohshiro K; Jogunoori W; Bao-Ngoc N; Li S; Osmanbeyoglu HU; Ajani JA; Mani SA; Houseman A; Wiznerowicz M; Chen J; Gu S; Ma W; Zhang J; Tong P; Cherniack AD; Deng C; Resar L; Weinstein JN; Mishra L; Akbani R
- Article: ONCOTARGET. 2018;9(28):19730-19744Danielsson F; Fasterius E; Sullivan D; Hases L; Sanli K; Zhang C; Mardinoglu A; Al-Khalili C; Huss M; Uhlén M; Williams C; Lundberg E
- Journal article: NATURE COMMUNICATIONS. 2017;8:16164Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramstrom M; Soderberg O; Williams C; Asplund A
- Journal article: CANCER RESEARCH. 2017;77:4401Archer A; Pettersson L; Gonzalez-Granillo M; Savva C; Korach-Andre M; Williams C
- Journal article: CANCER RESEARCH. 2017;77:2819Pettersson L; Saxena A; Vu T; Gustafsson J-A; Archer A; Williams C
- Article: CANCER LETTERS. 2017;396:42-52Monteiro FL; Vitorino R; Wang J; Cardoso H; Laranjeira H; Simoes J; Caldas M; Henrique R; Amado F; Williams C; Jeronimo C; Helguero LA
- Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):1-14Ma R; Karthik G-M; Lovrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
- Article: PLOS ONE. 2017;12(2):e0172832Simon M; Mesmar F; Helguero L; Williams C
- Article: ONCOTARGET. 2016;7(27):42159-42171Trang N-V; Wang J; Mesmar F; Mukhopadhyay S; Saxena A; McCollum CW; Gustafsson J-A; Bondesson M; Williams C
- Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(6):2689-2698Reins RY; Mesmar F; Williams C; McDermott AM
- Article: ONCOGENE. 2016;35(15):1955-1964Zhu J; Zhao C; Zhuang T; Jonsson P; Sinha I; Williams C; Stromblad S; Dahlman-Wright K
- Article: METHODS IN MOLECULAR BIOLOGY. 2016;1366:373-393Katchy A; Williams C
- Article: MOLECULAR ENDOCRINOLOGY. 2015;29(11):1634-1645Jonsson P; Coarfa C; Mesmar F; Raz T; Rajapakshe K; Thompson JF; Gunaratne PH; Williams C
- Article: CARCINOGENESIS. 2015;36(9):1051-1060Tsouko E; Wang J; Frigo DE; Aydogdu E; Williams C
- Journal article: PLOS ONE. 2015;10(6):e0132085Dey P; Velazquez-Villegas LA; Faria M; Turner A; Jonsson P; Webb P; Williams C; Gustafsson J-A; Stroem AM
- Article: PLOS ONE. 2015;10(5):e0128239Dey P; Velazquez-Villegas LA; Faria M; Turner A; Jonsson P; Webb P; Williams C; Gustafsson J-A; Stroem AM
- Article: MOLECULAR ONCOLOGY. 2014;8(8):1690-1702Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
- Article: FASEB JOURNAL. 2014;28(10):4247-4264Doria ML; Ribeiro AS; Wang J; Cotrim CZ; Domingues P; Williams C; Domingues MR; Helguero LA
- Article: ONCOGENE. 2014;33(34):4340-4351Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Stroemblad S; Treuter E; Dahlman-Wright K
- Article: CANCER RESEARCH. 2014;74(14):3983-3994Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
- Article: ENDOCRINE-RELATED CANCER. 2014;21(2):143-160Jonsson P; Katchy A; Williams C
- Article: TOXICOLOGICAL SCIENCES. 2014;138(1):21-35Katchy A; Pinto C; Jonsson P; Trang N-V; Pandelova M; Riu A; Schramm K-W; Samarov D; Gustafsson J-A; Bondesson M; Williams C
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(84):e51285Katchy A; Williams C
- Article: ENDOCR DISRUPTORS (AUSTIN). 2014;2(1):e29088Williams C; Bondesson M; Krementsov DN; Teuscher C
- Article: TOXICOLOGICAL SCIENCES. 2013;135(1):91-102Krementsov DN; Katchy A; Case LK; Carr FE; Davis B; Williams C; Teuscher C
- Article: CARCINOGENESIS. 2013;34(7):1431-1441Edvardsson K; Trang N-V; Kalasekar SM; Ponten F; Gustafsson J-A; Williams C
- Article: BREAST CANCER RESEARCH. 2013;15(3):R51Trang N-V; Vedin L-L; Liu K; Jonsson P; Lin JZ; Candelaria NR; Candelaria LP; Addanki S; Williams C; Gustafsson J-A; Steffensen KR; Lin C-Y
- Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1991-2003Dey P; Jonsson P; Hartman J; Williams C; Stroem A; Gustafsson J-A
- Article: CARCINOGENESIS. 2012;33(9):1684-1691Dahlman-Wright K; Qiao Y; Jonsson P; Gustafsson J-A; Williams C; Zhao C
- Article: CARCINOGENESIS. 2012;33(8):1502-1511Aydogdu E; Katchy A; Tsouko E; Lin C-Y; Haldosen L-A; Helguero L; Williams C
- Journal article: CANCER RESEARCH. 2012;72(8_Supplement):547Katchy AC; Pinto C; Bondesson M; Williams C
- Article: PLOS ONE. 2012;7(3):e32080Ehrlund A; Jonsson P; Vedin L-L; Williams C; Gustafsson J-A; Treuter E
- Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2012;128(3-5):145-153Katchy A; Edvardsson K; Aydogdu E; Williams C
- Journal article: CANCER RESEARCH. 2011;71(24_Supplement):p1-02-04-p1-02-04P1-02-04: Estrogen Receptor beta Inhibits Breast Cancer EMT by Regulating the Expression of miR-200.Thomas C; Gayani R; Nikolos F; Hao R; Katchy A; McCollum C; Williams C; Bondesson M; Krishnamurthy S; Esteva F; Gustafsson J-A
- Article: MOLECULAR ENDOCRINOLOGY. 2011;25(8):1326-1336Alvarez-Baron CP; Jonsson P; Thomas C; Dryer SE; Williams C
- Article: MOLECULAR ENDOCRINOLOGY. 2011;25(6):969-979Edvardsson K; Stroem A; Jonsson P; Gustafsson J-A; Williams C
- Journal article: CANCER RESEARCH. 2011;71(8_Supplement):271Alvarez-Baron CP; Jonsson P; Dryer S; Williams C
- Journal article: CANCER RESEARCH. 2009;69(24_Supplement):1162Williams C; Helguero L; Edvardsson K; Haldosén L; Gustafsson J
- Article: CANCER RESEARCH. 2009;69(15):6100-6106Hartman J; Edvardsson K; Lindberg K; Zhao C; Williams C; Strom A; Gustafsson J-A
- Article: BREAST CANCER RESEARCH. 2009;11(3):R26Williams C; Helguero L; Edvardsson K; Haldosen L-A; Gustafsson J-A
- Article: ONCOGENE. 2008;27(7):1019-1032Williams C; Edvardsson K; Lewandowski SA; Stroem A; Gustafsson J-A
- Article: BMC DEVELOPMENTAL BIOLOGY. 2007;7:129Svensson P; Williams C; Lundeberg J; Ryden P; Bergqvist I; Edlund H
- Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812Williams C; Wirta V; Meletis K; Wikstrom L; Carlsson L; Frisen J; Lundeberg J
- Article: BMC GENOMICS. 2006;7:75Richter K; Wirta V; Dahl L; Bruce S; Lundeberg J; Carlsson L; Williams C
- Article: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE. 2002;18(6):287-293Persson Å; Edström DW; Bäckvall H; Lundeberg J; Pontén F; Ros AM; Williams C
- Article: ONCOGENE. 2001;20(53):7770-7778Ling G; Ahmadian A; Persson Å; Undén AB; Afink G; Williams C; Uhlén M; Toftgård R; Lundeberg J; Pontén F
- Article: ANALYTICAL BIOCHEMISTRY. 2000;287(1):25-31Persson Å; Ling G; Williams C; Bäckvall H; Pontén J; Pontén F; Lundeberg J
- Article: AMERICAN JOURNAL OF PATHOLOGY. 1999;155(5):1467-1471Williams C; Pontén F; Moberg C; Söderkvist P; Uhlén M; Pontén J; Sitbon G; Lundeberg J
- Article: GENE. 1999;235(1-2):103-109Odeberg J; Ahmadian A; Williams C; Uhlén M; Pontén F; Lundeberg J
- Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 1999;8(5):433-438Yngveson A; Williams C; Hjerpe A; Lundeberg J; Söderkvist P; Pershagen G
- Article: ONCOGENE. 1998;17(14):1837-1843Ahmadian A; Ren ZP; Williams C; Pontén F; Odeberg J; Pontén J; Uhlén M; Lundeberg J
- Article: CANCER RESEARCH. 1998;58(11):2449-2455Williams C; Pontén F; Ahmadian A; Ren ZP; Ling G; Rollman O; Ljung A; Jaspers NGJ; Uhlén M; Lundeberg J; Pontén J
- Article: GENOMICS. 1998;50(2):213-221Odeberg J; Rosok O; Gudmundsson GH; Ahmadian A; Roshani L; Williams C; Larsson C; Pontén F; Uhlén M; Åsheim HC; Lundeberg J
- Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s145Gao L; Ponten F; Williams C; Lundeberg J; Ponten J; Uhlen M
- Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s48Pontén F; Williams C; Ahmadian A; Ling G; Uhlén M; Lundeberg J; Pontén J
- Article: CLINICAL CHEMISTRY. 1998;44(3):455-462Williams C; Norberg T; Ahmadian A; Pontén F; Bergh J; Inganäs M; Lundeberg J; Uhlén M
- Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1997;382(1-2):45-55Ponten F; Williams C; Ling G; Ahmadian A; Nister M; Lundeberg J; Ponten J; Uhlen M
- Article: ONCOGENE. 1997;15(9):1059-1067Ponten F; Berg C; Ahmadian A; Ren ZP; Nister M; Lundeberg J; Uhlen M; Ponten J
- Article: AMERICAN JOURNAL OF PATHOLOGY. 1997;150(5):1791-1803Ren ZP; Ahmadian A; Ponten F; Nister M; Berg C; Lundeberg J; Uhlen M; Ponten J
- Journal article: MELANOMA RESEARCH. 1996;6(SUPPLEMENT 1):s53Pontén F; Berg C; Uhlén M; Pontén J
- Article: CLINICAL CHEMISTRY. 1995;41(10):1461-1466BERG C; HEDRUM A; HOLMBERG A; PONTEN F; UHLEN M; LUNDEBERG J
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All other publications
- Preprint: BIORXIV. 2023Sommerauer C; Gallardo-Dodd C; Savva C; Hases L; Birgersson M; Indukuri R; Shen J; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke V; Archer A; Williams C; Kutter C
- Review: ENDOCRINOLOGY. 2023;164(6):bqad063Birgersson M; Indukuri R; Antonson P; Nalvarte I; Archer A; Williams C
- Conference publication: BIOPHYSICAL JOURNAL. 2023;122(3):289AJain S; Birgersson M; Kipen J; Jalden J; Stemme G; Niklaus F; Raja SN; Williams C; Herland A
- Preprint: MEDRXIV. 2022Perez-Zabaleta M; Williams C; Cetecioglu Z
- Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):S640Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
- Conference publication: CANCER RESEARCH. 2022;82(4):p1-07-07-p1-07-07Schagerholm C; Robertson S; Holm B; Lindberg K; Sifakis E; Hases L; Williams C; Hartman J
- Preprint: SSRN ELECTRONIC JOURNAL. 2022Perez-Zabaleta M; Archer A; Khatami K; Jafferali MH; Nandy P; Atasoy M; Birgersson M; Williams C; Cetecioglu Z
- Conference publication: CANCER RESEARCH. 2020;80(16):2081Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
- Conference publication: CANCER RESEARCH. 2020;80(16):4085Song D; He H; Sinha I; Pettersson L; Yan F; Haldosen L-A; Zhao C; Williams C
- Preprint: BIORXIV. 2020Hases L; Archer A; Indukuri R; Birgersson M; Savva C; Korach-André M; Williams C
- Preprint: RESEARCH SQUARE. 2019Cheng Y; Qu X; Dong Z; Zeng Q; Ma X; Jia Y; Li R; Jiang X; Williams C; Wang T; Xia W
- Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2018;29(26)Gnann C; Casals AM; Xu H; Kheder S; Archer A; Mulder J; Mitsios N; Williams C; Lundberg E; Ayoglu B
- Review: CANCER LETTERS. 2018;438:24-31Zheng D; Williams C; Vold JA; Nguyen JH; Harnois DM; Bagaria SP; McLaughlin SA; Li Z
- Conference publication: CANCER RESEARCH. 2017;77:3614Andersson S; Sundberg M; Pristovsek N; Ibrahim A; Jonsson P; Katona B; Clausson C-M; Zieba A; Ramstrom M; Soderberg O; Williams C; Asplund A
- Conference publication: CANCER RESEARCH. 2017;77:5493Indukuri R; Wang J; Mesmar F; Williams C
- Conference publication: CANCER RESEARCH. 2017;77:4920Ibrahim AF; Thomas Q; Saxena A; Williams C
- Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(12)Reins RY; Mesmar F; Williams C; McDermott AM
- Review: CANCER LETTERS. 2016;372(1):48-56Williams C; DiLeo A; Niv Y; Gustafsson J-A
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1849(2):142-151Bondesson M; Hao R; Lin C-Y; Williams C; Gustafsson J-A
- Conference publication: CANCER RESEARCH. 2013;73:p4-07-12-p4-07-12Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
- Review: ECANCERMEDICALSCIENCE. 2013;7:370Williams C; Lin C-Y
- Conference publication: CANCER RESEARCH. 2013;73(8):4915Ma R; Govindasamy KM; Rosin G; Gustafsson J; Katchy A; Lindstrom L; Hilliges C; Viberg L; Blomqvist L; Frisell J; Williams C; Fredriksson I; Bergh J; Hartman J
- Conference publication: CANCER RESEARCH. 2012;72:1207Dey P; Jonsson P; Hartman J; Williams C; Gustafsson J-A; Strom A
- Conference publication: CANCER RESEARCH. 2011;71:p3-03-08-p3-03-08Williams C; Aydogdu E; Katchy A; Lin C-Y; Baldosen L-A; Helguero L
- Conference publication: CANCER RESEARCH. 2010;70:2076Aydogdu E; Helguero L; Haldosen L-A; Williams CM
- Conference publication: CANCER RESEARCH. 2010;70:2921Edvardsson K; Strom A; Gustafsson J-A; Williams C
- Conference publication: CANCER RESEARCH. 2009;69(24):589S-590SWilliams C; Helguero L; Edvardsson K; Haldosen L-A; Gustafsson J-A
- Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2006;5(10):S233Schwend T; Imamov O; Williams C; Gustafsson J-A
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2001;117(3):815Edström DW; Persson Å; Bäckvall H; Lundeberg J; Pontén F; Ros AM; Williams C
- Conference publication: EPIDEMIOLOGY. 1999;10(4):S83Yngveson A; Williams C; Hjerpe A; Lundeberg J; Söderkvist P; Pershagen G
- Book chapter: SKIN CANCER AND UV RADIATION. 1997;p. 709-714Ponten F; Berg C; Uhlen M; Ponten J
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Grants
- Swedish Research Council1 January 2023 - 31 December 2026Colorectal cancer is a leading cause of cancer mortality. The disease exhibits distinct sex differences in incidence, tumor location, tumor characteristics, and survival, and estrogen reduces the incidence and mortality. Emerging data support that estrogen receptor beta (ERβ) mediates this effect. We have demonstrated that intestinal ERβ is protective in both sexes. Our preliminary data show that ERβ in the tumor microenvironment reduces the number of tumor-infiltrating macrophages, stemness markers, and stabilizes circadian clock regulation, in part by modifying inflammatory NFkB signaling. We will test our specific hypotheses using intestinal-specific knockout mice, tumor models, engineered cell lines, organotypic patient-derived cultures, and advanced technologies. Technologies includes high-throughput hyperplex immunofluorescence COMET for spatial proteomics to characterize the immune cell landscape in situ, multiplex plasma cytokine analysis, and capture Hi-C and RIME to deduce and characterize the related molecular mechanisms. The overarching goal is to understand the critical mechanistic background needed to develop useful strategies for chemoprevention and precision medicine, for example, co-administration of receptor-selective ligands and immune checkpoint inhibitors. In addition, we will provide an in-depth understanding of colitis, colon carcinogenesis, peripheral circadian rhythmicity, stemness, and related sex differences.
- Swedish Cancer Society1 January 2022Colon and rectal cancer is the third most common cause of cancer death for both men and women in Sweden. There is a great need to develop better prevention, treatments and prognostic biomarkers. The female sex hormone estrogen is protective, but estrogen has side effects that make it unsuitable as a contraceptive. We have shown that a special estrogen receptor, ERbeta, in the intestinal epithelial cells is the protein that mediates the protective effect of estrogen. Our hypothesis is that activation of the ERbeta receptor can be used for a safe preventive treatment with few or no side effects. Our new results show that the receptor has a cancer-protective effect in both sexes. In addition, we see a strong anti-inflammatory effect in the intestine and signs that the receptor also seems to be able to regulate the biological circadian rhythm of the intestine. Both inflammation and the intestinal circadian rhythm are associated with cancer development. A partial hypothesis is that the intestinal microflora is also affected by ERbeta activation. Our aim here is to explore exactly how this works and clarify how the receptor protects against the onset of cancer. Our goal is to be able to develop a new safe preventive treatment that protects both men and women. Such treatment may be suitable for people in risk groups who have hereditary syndromes that increase the risk of rectal and colon cancer, as well as for the elderly.
- QuantumSense - Quantum Tunneling Sensing of Biomolecules for High-Throughput Decoding of DNA and RNASwedish Research Council1 December 2018 - 30 November 2024
- Swedish Research Council1 January 2018 - 31 December 2021
- VINNOVA1 June 2014 - 28 February 2018
- National Cancer Institute1 August 2013 - 31 May 2019
- Epigenetic regulation in mammary stem/progenitor cells and its contribution to malignant transformationFundação para a Ciência e Tecnologia15 March 2012 - 14 July 2015