Cecilia Williams

Cecilia Williams

Principal Researcher
Visiting address: Blickagången 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 GUT Williams, 171 77 Stockholm

About me

  • Hormone signalling and non-coding RNAs in cancer

    Cecilia Williams leads a group at KI that is shared with her lab at KTH and SciLifeLab. She received her PhD training in DNA sequencing technologies and the p53 tumor suppressor gene at KTH, postdoc training in gene expression profiling techniques and stem cells, and was later a researcher at Karolinska Institutet where she studied the role of estrogen receptor beta. In 2009, she joined the Center of Nuclear Receptors and Cell Signaling at University of Houston as Assistant Professor and received a tenured Associate Professorship in 2015. Her main activities at BioNut are focused at understanding hormonal signalling and the role of non-coding RNAs in cancer, and include supervision of doctoral students.


    Education
    1994 M.S. (Civ. Ing.) in Chemical Engineering with specialization in Biotechnology, KTH Royal Institute of Technology, Stockholm
    2002 Ph.D. Biotechnology, KTH Royal Institute of Technology. /Molecular Archaeology of Cancer - Analysis of the Human p53 Tumor Suppressor Gene.

Research

  • Hormone signalling and non-coding RNAs in cancer

    The Williams’ group focuses on understanding key molecular mechanisms in cancer, applying a combination of large-scale genomic approaches, focused mechanistic experiments and animal studies. The goal is to understand critical pathways so that we can define biomarkers of their activity and suggest better cancer treatments and preventive approaches. The hormone estrogen increases the risk of breast cancer, but can simultaneously protect against colorectal cancer. It is not understood exactly how, but if we can achieve a detailed knowledge of this mechanism, we could design approaches that can protect against colon cancer while not promoting breast cancer.

    Estrogenic signaling is mediated by the estrogen receptors, ERalpha, ERbeta and GPER1. ERalpha and ERbeta are ligand-activated nuclear receptors and as such excellent therapeutic targets. Our research focuses on understanding estrogen-induced pathways in breast and colon cancer, and the impact that environmental or dietary estrogenic exposure may have. Related to this, is the identification of molecular mechanisms involving microRNAs and long non-coding RNAs, molecules with great potential as novel biomarkers and therapeutic targets. These molecules are likely to contribute to the estrogenic effects, but this area remains to be explored. Our previous work include identification of the estrogen-regulated transcriptome, the roles of specific microRNAs in cell migration, and expression and regulations of lncRNAs, with a focus on cancer.

Teaching

  • Course responsible, teacher, and examiner for Clinical Applications of Biotechnology (6.0 credits, 2019-2023), Master's programme in Molecular Techniques in 
    Life Science (SciLifeLab)

Selected publications

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2023 - 31 December 2026
    Colorectal cancer is a leading cause of cancer mortality. The disease exhibits distinct sex differences in incidence, tumor location, tumor characteristics, and survival, and estrogen reduces the incidence and mortality. Emerging data support that estrogen receptor beta (ERβ) mediates this effect. We have demonstrated that intestinal ERβ is protective in both sexes. Our preliminary data show that ERβ in the tumor microenvironment reduces the number of tumor-infiltrating macrophages, stemness markers, and stabilizes circadian clock regulation, in part by modifying inflammatory NFkB signaling. We will test our specific hypotheses using intestinal-specific knockout mice, tumor models, engineered cell lines, organotypic patient-derived cultures, and advanced technologies. Technologies includes high-throughput hyperplex immunofluorescence COMET for spatial proteomics to characterize the immune cell landscape in situ, multiplex plasma cytokine analysis, and capture Hi-C and RIME to deduce and characterize the related molecular mechanisms. The overarching goal is to understand the critical mechanistic background needed to develop useful strategies for chemoprevention and precision medicine, for example, co-administration of receptor-selective ligands and immune checkpoint inhibitors. In addition, we will provide an in-depth understanding of colitis, colon carcinogenesis, peripheral circadian rhythmicity, stemness, and related sex differences.
  • Swedish Cancer Society
    1 January 2022
    Colon and rectal cancer is the third most common cause of cancer death for both men and women in Sweden. There is a great need to develop better prevention, treatments and prognostic biomarkers. The female sex hormone estrogen is protective, but estrogen has side effects that make it unsuitable as a contraceptive. We have shown that a special estrogen receptor, ERbeta, in the intestinal epithelial cells is the protein that mediates the protective effect of estrogen. Our hypothesis is that activation of the ERbeta receptor can be used for a safe preventive treatment with few or no side effects. Our new results show that the receptor has a cancer-protective effect in both sexes. In addition, we see a strong anti-inflammatory effect in the intestine and signs that the receptor also seems to be able to regulate the biological circadian rhythm of the intestine. Both inflammation and the intestinal circadian rhythm are associated with cancer development. A partial hypothesis is that the intestinal microflora is also affected by ERbeta activation. Our aim here is to explore exactly how this works and clarify how the receptor protects against the onset of cancer. Our goal is to be able to develop a new safe preventive treatment that protects both men and women. Such treatment may be suitable for people in risk groups who have hereditary syndromes that increase the risk of rectal and colon cancer, as well as for the elderly.
  • Swedish Research Council
    1 January 2018 - 31 December 2021
  • National Cancer Institute
    1 August 2013 - 31 May 2019
  • Epigenetic regulation in mammary stem/progenitor cells and its contribution to malignant transformation
    Fundação para a Ciência e Tecnologia
    15 March 2012 - 14 July 2015

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