Carl Jorns

Carl Jorns

Anknuten till Forskning | Docent
E-postadress: carl.jorns@ki.se
Besöksadress: Hälsovägen, Enheten för transplantationskirurgi F82, 14186 Stockholm
Postadress: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Transplantation, 141 52 Huddinge

Om mig

  • Carl studied medicine at Albert-Ludwigs-Universität Freiburg, Germany and
    obtained a doctoral degree at the department of Virology with a thesis on
    interferon stimulated genes. He received clinical surgical training in
    general and transplantation surgery at Karolinska University Hospital. Carl
    obtained his PhD at Karolinska Institutet in 2015 on clinical and
    experimental hepatocyte transplantation. Carl is currently the head
    of liver transplantation at the Department of Transplantation Surgery,
    Karolinska University Hospital.

Forskningsbeskrivning

  • Carl´s research involves translational research in organ donation and
    transplantation as well as regenerative medicine. His research includes organ
    donation from neonatal donors, clinical and experimental hepatocyte
    transplantation.

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2023 - 31 December 2025
    The covid-19 pandemic has created tremendous damage to the world´s economy and society, but it has also highlighted the importance of science and innovations as tools to survive and respond to life treatening challenges. Vaccines based on mRNA technology have been massively manufactured and administered, dissipating any doubg about the feasibility of this approach. This technology has been initially developed to target cancer antigens and had shown promising results in small clinical trials. Vaccination is one of the most succesfull form of immunotherapy and can be directed towards multiple antigens, the challenge in the filed of cancer immunotherapy is to identify the right target to achieve tumor eradication. In 2020 our team started a project focused on the identification of immunogeneic neoantigens in patients affected by HCC. At today we collected and sequenced tumors from 16 individulas and we identified several neoantigens that can raise a T cell response in the patients. With the present project we aim at complementing the screening of T cell immunogeic neoantigens with the design of specifc mRNA vaccines that can elicit immune response as support/integration of adoptive cell therapy.

Anställningar

  • Anknuten till Forskning, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2025-2028

Examina och utbildning

  • Docent, transplantation, Karolinska Institutet, 2022
  • Medicine Doktorsexamen, Institutionen för klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2015

Nyheter från KI

Kalenderhändelser från KI