Anna Rising

Anna Rising

Forskare
E-postadress: anna.rising@ki.se
Besöksadress: Blickagången 16, 14152 Flemingsberg
Postadress: H7 Medicin, Huddinge, H7 CeRM Rising, 171 77 Stockholm
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Om mig

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Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2025 - 31 December 2028
    This project addresses unmet needs within orthopedic care, focusing specifically on non-union fractures and anterior cruciate ligament (ACL) rupture, through the development of novel treatment strategies. This will be done by using a novel biomaterial - spider silk - reknown for its biocompatibility and impressive mechanical properties. Specifically, we will build on our ability to produce artificial spider silk fibers using only water-based solutions and ambient temperatures to engineer a novel type of ligament replacements that optionally can harbor growth factors. In another line of research, we have invented a method for making hydrogels from soluble spider silk proteins. Human mesenchymal stem cells can be encapsulated in these hydrogels that form spontaneously and within minutes when the temperature is increased to 37°C. This groundbreaking achievement offers a promising avenue for the creation of injectable, optionally bioactive, scaffolds. Our research extends beyond scaffold development to explore the rejuvenation of MSCs sourced from elderly individuals, who often exhibit diminished regenerative capacity. This multidisciplinary approach, which integrates advanced biomaterials, tissue engineering techniques, and targeted cellular therapies, holds promise for transforming the management of fractures, ACL injuries, and critical bone defects.
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2024 - 31 December 2026
    The overall objective of this proposal is to increase our knowledge of how nature designs and produces high-performance sustainable fibers, and to invent bioinspired processes with the aim of making truly biomimetic spider silk fibers. Our research is focused on spider silk, the toughest fiber known to man, and the gland in which it is produced. We know that there are several cell types in the gland that secrete specific combinations of proteins, and these are added sequentially to the spinning feedstock, without mixing. This means that the spider silk fiber likely contains several layers, but the number of layers and their protein composition remain largely unknown. By using state of the art sequencing technologies we will determine the anatomical localization of the different cell types, and proteomics of silk fibers that are gradually dissolved will be used to fortify our findings. Finally, we will produce recombinant silk proteins and design spinning devices that allow us to recapitulate architecture and composition of the native silk fiber, and produce truly biomimetic artificial silk fibers.
  • VINNOVA
    22 December 2023 - 28 March 2024
  • ArtSilkTex
    Europeiska Forskningsrådet
    1 September 2022 - 29 February 2024
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2020 - 31 December 2022
  • Swedish Research Council
    1 January 2020 - 31 December 2023
  • European Research Council
    1 May 2019 - 31 October 2024
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2019 - 14 February 2019
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2016 - 31 December 2018
  • Swedish Research Council
    1 January 2015 - 31 December 2018
  • Swedish Research Council
    1 January 2012 - 31 December 2012
  • Swedish Research Council
    1 January 2011 - 31 December 2013

Anställningar

  • Forskare, Medicin, Huddinge, Karolinska Institutet, 2024-

Examina och utbildning

  • Docent, Sveriges Lantbruksuniversitet (SLU), 2013

Nyheter från KI

Kalenderhändelser från KI