Anna Krook
Om mig
Jag är professor i integrativ cellfysiologi vid institutionen för fysiologi och farmakologi, och ordförande för det strategiska forskningsprogrammet i diabetes. Min forskning syftar till att förstå hur insulinkänslighet regleras, speciellt i skelettmuskeln.
Forskningsbeskrivning
Jag är intresserad av hur insulinsignalen fungerar på molekylär nivå. Min forskning fokuserar för närvarande på tre breda områden, alla centrerade kring skelettmuskelmetabolism. Dessa inkluderar studier kring hur icke-kodande RNA styr muskelmetabolism och insulinkänslighet, transkriptionell reglering av skelettmuskelmetabolism och effekterna av metaboliter, hormoner och andra cirkulerande faktorer. Vi är intresserade av hur insulinkänslighet och glukosmetabolism påverkas av typ 2 diabetes och av träning, både på cellnivå och genom att studera personer med eller utan typ 2 diabetes efter olika träningsinterventioner.
Jag är kandidat som lärarrepresentant i konsistoriet. Som sådan anser jag att det är viktigt att KIs forskare och lärare har en röst, och att vi strävar efter att upprätthålla akademisk frihet och ett kollegialt universitet för att fortsätta vara ett världsledande forskningsinstitut.
Min vision för Karolinska Institutet
Som forskare på Karolinska Insitutet tycker jag att det är viktigt att vi som är forskare och lärare har så goda förutsättningar som möjligt, att våra röster hörs och att vi värnar om det kollegiala styret. Dessa faktorer är viktiga för är att stärka Karolinska Institutets position som en världsledande institution inom medicinsk forskning och utbildning. Jag är särskilt intresserad avforskarrollen och att vidareutveckla tvärvetenskapliga forskningsinitiativ som kan adressera dagens globala hälsoutmaningar. Genom att föra samman expertis från olika discipliner och sektorer vill jag bidra till att skapa innovativa lösningar som förbättrar förståelsen av patologiska mekanismer och som i förlängningen leder till viktiga medicinska insikter.
- Jag ser fram emot möjligheten att bidra med mina kunskaper och erfarenheter för att stärka Karolinska Institutets strategiska mål och framtid
Artiklar
- Article: MOLECULAR METABOLISM. 2024;86:101968
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347
- Article: NATURE METABOLISM. 2024;6(6):1024-1035
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2024;155:155834
- Article: CELL REPORTS MEDICINE. 2024;5(1):101348
- Journal article: DIABETES. 2023;72(Supplement_1)
- Article: NATURE REVIEWS ENDOCRINOLOGY. 2023;19(5):250-251
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2023;324(4):E289-E298
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120
- Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2022;135:155268
- Article: SCIENCE ADVANCES. 2022;8(36):eabo3192
- Article: NATURE GENETICS. 2022;54(9):1332-1344
- Article: DIABETES. 2022;71(4):624-636
- Article: NATURE METABOLISM. 2022;4(2):190-202
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;321(5):C770-C778
- Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
- Article: NATURE COMMUNICATIONS. 2021;12(1):5948
- Article: DIABETOLOGIA. 2021;64(9):2077-2091
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2021;321(2):E203-E216
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;118:154726
- Article: SCIENCE ADVANCES. 2021;7(11):eabc2931
- Article: CELL METABOLISM. 2020;32(5):844-859.e5
- Article: OBESITY. 2020;28(Suppl 1):S38-S45
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(6):dgaa165-2041
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2020;318(3):C615-C626
- Article: CELL METABOLISM. 2020;31(2):375-390.e11
- Article: NATURE COMMUNICATIONS. 2020;11(1):470
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2020;318(1):E1-E10
- Article: THE FASEB JOURNAL. 2019;33(9):10551-10562
- Article: DIABETES. 2019;68(7):1403-1414
- Article: THE FASEB JOURNAL. 2019;33(5):6269-6280
- Article: JOURNAL OF NUTRITION AND METABOLISM. 2019;2019:1840374-8
- Article: DIABETES. 2019;68(3):515-526
- Article: MOLECULAR METABOLISM. 2019;20:79-88
- Article: DIABETOLOGIA. 2019;62(2):233-237
- Article: ANALYTICA CHIMICA ACTA. 2018;1037:338-350
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(12):4465-4477
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2018;315(5):E995-E1004
- Article: MOLECULAR METABOLISM. 2018;16:12-23
- Article: JOURNAL OF OBESITY. 2018;2018:7461903-8
- Article: ACTA PHYSIOLOGICA. 2018;223(3):e13051
- Article: PHYSIOLOGICAL REPORTS. 2018;6(12):e13739
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(9):E2048-E2057
- Article: DIABETOLOGIA. 2018;61(2):424-432
- Article: EXPERIMENTAL CELL RESEARCH. 2017;360(1):47-54
- Article: MOLECULAR METABOLISM. 2017;6(7):621-630
- Article: DIABETES. 2017;66(7):1807-1818
- Article: DIABETES. 2017;66(3):651-662
- Article: PLOS ONE. 2017;12(4):e0175441
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1861(12):2130-2138
- Article: PLOS MEDICINE. 2016;13(11):e1002179
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761
- Article: MOLECULAR METABOLISM. 2016;5(3):171-183
- Article: MOLECULAR METABOLISM. 2016;5(3):184-197
- Article: BIOCHEMICAL JOURNAL. 2015;472(2):147-156
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(6):643-655
- Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2015;12(5):315-324
- Article: DIABETES CARE. 2015;38(6):1154-1160
- Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2015;11(3):592-601
- Article: PHYSIOLOGICAL GENOMICS. 2015;47(3):45-57
- Article: JOURNAL OF ENDOCRINOLOGY. 2015;224(3):303-313
- Article: CELL. 2014;159(1):33-45
- Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2014;10(4):671-678
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1359-E1366
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(9):E1071-E1080
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;712(1-3):16-21
- Article: CELL REPORTS. 2013;3(4):1020-1027
- Article: DIABETES. 2013;62(2):355-361
- Article: DIABETES. 2013;62(2):457-465
- Article: PLOS ONE. 2013;8(4):e61903
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2013;29(1):25-32
- Article: CELL METABOLISM. 2012;15(3):405-411
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2012;61(2):175-185
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(40):34567-34574
- Article: MEDICAL CLINICS OF NORTH AMERICA. 2011;95(5):953-969
- Article: DIABETES. 2011;60(8):2061-2067
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2011;110(5):1204-1210
- Article: DIABETES. 2011;60(3):925-935
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2011;27(3):286-297
- Article: THROMBOSIS AND HAEMOSTASIS. 2011;105(1):122-130
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2010;95(5):2359-2366
- Article: CELL METABOLISM. 2009;10(3):189-198
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2009;25(3):250-258
- Article: DIABETES. 2008;57(8):2066-2073
- Article: DIABETES. 2008;57(6):1508-1516
- Article: CELL. 2008;132(3):375-386
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(27):19313-19320
- Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2007;2(4):477-485
- Article: DIABETES. 2007;56(6):1630-1637
- Article: PLOS MEDICINE. 2007;4(5):e158-879
- Article: MOLECULAR ENDOCRINOLOGY. 2006;20(12):3364-3375
- Article: ACTA PHYSIOLOGICA. 2006;188(3-4):207-216
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2006;22(6):492-498
- Article: CELL METABOLISM. 2006;4(1):89-96
- Article: CYTOTECHNOLOGY. 2005;48(1-3):89-95
- Article: DIABETES. 2005;54(6):1692-1697
- Article: DIABETES. 2005;54(4):1157-1163
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(3):E553-E557
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(24):25211-25218
- Article: DIABETES. 2004;53(6):1424-1428
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2004;286(6):C1410-C1416
- Article: ACTA PHYSIOLOGICA. 2004;180(4):395-403
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;286(2):E194-E200
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(1):127-132
- Article: JOURNAL OF PHYSIOLOGY. 2003;550(1):305-315
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(5):991-998
- Article: JOURNAL OF PHYSIOLOGY. 2003;546(2):327-335
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2003;23(1):21-30
- Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259
- Article: JOURNAL OF PHYSIOLOGY. 2001;536(1):273-282
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34
- Article: BIOCHEMICAL JOURNAL. 2000;351(Pt 3):805-810
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721
- Article: DIABETES. 2000;49(2):284-292
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;277(6):R1690-R1696
- Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330
- Article: DIABETOLOGIA. 1999;42(7):826-830
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142
- Article: DIABETES. 1999;48(3):664-670
- Article: THE FASEB JOURNAL. 1998;12(13):1379-1389
- Article: DIABETES. 1998;47(9):1528-1531
- Article: DIABETES. 1998;47(8):1281-1286
- Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160
- Article: DIABETES. 1997;46(12):2110-2114
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(48):30208-30214
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(43):26833-26840
- Article: DIABETIC MEDICINE. 1997;14(3):228-234
- Journal article: APMIS. 1997;105(3):213-220
- Article: THE LANCET. 1996;347(9015):1586-1590
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 1996;81(5):1979-1983
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(12):7134-7140
- Journal article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES. 1995;14(4):297-304
- Journal article: DIABETES. 1994;43(3):357-368
- Journal article: THE LANCET. 1993;342(8866):277-278
- Journal article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES. 1993;12(4):289-293
- Journal article: DIABETOLOGIA. 1992;35(5):486-489
- Journal article: JOURNAL OF VIROLOGY. 1991;65(10):5203-5210
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Alla övriga publikationer
- Preprint: BIORXIV. 2024
- Preprint: BIORXIV. 2024
- Editorial comment: DIABETOLOGIA. 2023;66(10):1762-1764
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839.1-83839
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S79-S80
- Editorial comment: DIABETOLOGIA. 2022;65(11):1755-1757
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S84-S85
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S42-S43
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S121-S122
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S121
- Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(1):37-49
- Conference publication: FASEB JOURNAL. 2017;31
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:7
- Conference publication: DIABETOLOGIA. 2016;59:S325
- Conference publication: DIABETOLOGIA. 2016;59:S170
- Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2016;12(1):7-8
- Editorial comment: DIABETOLOGIA. 2016;59(1):5-8
- Corrigendum: JOURNAL OF ENDOCRINOLOGY. 2015;226(3):X1
- Conference publication: DIABETOLOGIA. 2015;58:S300
- Editorial comment: DIABETES. 2014;63(4):1169-1170
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:33
- Corrigendum: CELL REPORTS. 2013;3(5):1755
- Review: TRENDS IN CELL BIOLOGY. 2013;23(5):203-209
- Editorial comment: DIABETES. 2013;62(4):1024-1025
- Editorial comment: DIABETOLOGIA. 2012;55(10):2562-2564
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A32
- Editorial comment: JOURNAL OF ENDOCRINOLOGY. 2011;211(1):1-2
- Corrigendum: JOURNAL OF APPLIED PHYSIOLOGY. 2011;111(2):622
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:331
- Review: LAKARTIDNINGEN. 2010;107(45):2802-2805
- Conference publication: DIABETOLOGIA. 2010;53
- Conference publication: DIABETOLOGIA. 2010;53:S43
- Conference publication: DIABETOLOGIA. 2010;53
- Conference publication: DIABETOLOGIA. 2010;53:S80
- Review: PHARMACOLOGICAL REVIEWS. 2009;61(3):373-393
- Review: DIABETOLOGIA. 2009;52(7):1231-1239
- Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2009;10(2)
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:80
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:647
- Review: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA. 2008;37(4):887-903
- Editorial comment: DIABETOLOGIA. 2008;51(7):1097-1099
- Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2008;70:11
- Published conference paper: ACTA PHYSIOLOGICA. 2008;192(1):37-48
- Corrigendum: ACTA PHYSIOLOGICA. 2007;189(1):101
- Editorial comment: DIABETOLOGIA. 2006;49(5):819-821
- Conference publication: DIABETOLOGIA. 2006;49:22
- Conference publication: DIABETOLOGIA. 2006;49:21-22
- Conference publication: DIABETOLOGIA. 2006;49:411
- Review: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES. 2003;111(4):191-197
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;986:449-452
- Conference publication: DIABETOLOGIA. 2002;45:A271
- Conference publication: DIABETOLOGIA. 2002;45:A189-A190
- Conference publication: DIABETOLOGIA. 2002;45:A22
- Review: DIABETOLOGIA. 2000;43(7):821-835
- Conference publication: INTERNATIONAL JOURNAL OF PSYCHOLOGY. 2000;35(3-4):13
- Conference publication: DIABETOLOGIA. 2000;43:A87
- Conference publication: DIABETOLOGIA. 1999;42:A178
- Conference publication: DIABETES. 1999;48:A22
- Conference publication: DIABETOLOGIA. 1999;42:A178
- Conference publication: DIABETOLOGIA. 1999;42:A178
- Conference publication: DIABETOLOGIA. 1999;42:A171
- Conference publication: DIABETOLOGIA. 1998;41:A189
- Conference publication: DIABETOLOGIA. 1998;41:A11
- Conference publication: DIABETES. 1998;47:A237
- Conference publication: DIABETOLOGIA. 1998;41:A263
- Conference publication: DIABETES. 1998;47:A4
- Review: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. 1997;90(9):557-562
- Conference publication: DIABETOLOGIA. 1997;40:148
- Editorial comment: CLINICAL ENDOCRINOLOGY. 1996;45(2):237-238
- Conference publication: DIABETES. 1996;45:1284
- Published conference paper: QUARTERLY JOURNAL OF MEDICINE. 1996;89(11):874
- Review: BAILLIERE'S CLINICAL ENDOCRINOLOGY AND METABOLISM. 1996;10(1):97-122
- Other: NEW ENGLAND JOURNAL OF MEDICINE. 1995;333(21):1386-1390
- Other: PRENATAL DIAGNOSIS. 1995;15(7):669-671
- Conference publication: DIABETOLOGIA. 1995;38:A69
- Conference publication: DIABETOLOGIA. 1995;38:A65
- Conference publication: DIABETES. 1995;44:A244
- Conference publication: DIABETES. 1995;44:A142
- Conference publication: DIABETES. 1995;44:A84
- Conference publication: JOURNAL OF MEDICAL GENETICS. 1994;31(2):170
- Conference publication: DIABETOLOGIA. 1993;36:A52
- Conference publication: DIABETOLOGIA. 1993;36:A4
- Conference publication: DIABETES. 1993;42:A95
- Conference publication: JOURNAL OF ENDOCRINOLOGY. 1992;135:O37
- Conference publication: DIABETOLOGIA. 1992;35:A71
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Forskningsbidrag
- Genomic plasticity and metabolic memory of skeletal muscle insulin resistanceWenner-Gren Foundation15 March 2024
- Swedish Research Council1 January 2023 - 31 December 2026
- Swedish Research Council1 January 2019 - 31 December 2022
- Knut and Alice Wallenberg Foundation1 January 2018 - 1 January 2021
- Swedish Research Council1 January 2013 - 31 December 2017
- Swedish Research Council1 January 2009 - 31 December 2013
Anställningar
- Professor, Fysiologi och farmakologi, Karolinska Institutet, 2010-
Examina och utbildning
- Docent, Cellfysiologi, Karolinska Institutet, 2002
Priser och utmärkelser
- The DPLU/LUDC Nordic Prize, DPLU/LUDC, 2013