Anna Krook
About me
I am a Professor of Integrative Physiology at the Department of Physiology and Pharmacology. I currently serve as teacher representative in Konsistoriet. I am Deputy Editor-in-Chief of Diabetologia and Associate Editor of American Journal of Physiology, Endocrinology and Metabolism. (Photo credit Fredrik Persson)
Education
Bachelor of Science (Class I, Hons), Biological Sciences, University of East Anglia, United Kingdom;Master of Science, Department of Pathology, Queens University, Canada;
Doctor of Philosophy, School of Clinical Medicine, University of Cambridge, United Kingdom
Research
I completed my doctoral studies at the University of Cambridge, UK, focusing on insulin receptor mutations in patients with severe syndromes of insulin resistance. Since then my research interest is focused on understanding insulin action at the molecular level. Work in my research group is currently focused on three broad areas, all centred around skeletal muscle metabolism. These include understanding the role non-coding RNA directs muscle metabolism and insulin sensitivity, transcriptional regulation of skeletal muscle metabolism and the effects of metabolites, hormones and other circulatory factors. We are interested in how insulin sensitivity and glucose metabolism are affected by type 2 diabetes and by exercise, both at the cellular level and by studying people with or without type 2 diabetes after various exercise interventions.
Link to the research group home page is here: https://ki.se/en/fyfa/integrative-physiology
Teaching
I am course director for the 15 credit course in the Master's Programme in Translational Physiology and Pharmacology, given in the spring every year. Please find link below: https://education.ki.se/student/physiological-and-pharmacological-mechanisms-and-experimental-approaches-15-credits/4ff002
Articles
- Article: DIABETOLOGIA. 2026;69(6):1643-1658Abdelmoez AM; Jollet M; Yu X; Rizo-Roca D; Marica AA; De Zevallos JO; Dollet L; Borg ML; Bjornholm M; Checa A; Olsson T; Otten J; Zierath JR; Krook A; Schwartz TW; Chibalin AV; Pillon NJ
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2026;111(2):366-374Bjornsdotter-Oberg S; Koman A; Skorpil M; Ryden H; Lanner JT; Krook A; Nilsson I-L; Pillon NJ; Nylen C
- Article: JOURNAL OF SPORT AND HEALTH SCIENCE. 2025;15:101091Katayama M; Caria E; Van Simaeys D; Sanz AY; Barres R; Caidahl K; Wiklander OPB; El Andaloussi S; Berggren P-O; Zierath JR; Krook A
- Article: DIABETOLOGIA. 2025;68(9):2023-2035Keller MJ; Brady AJ; Smith JAB; Savikj M; MacGregor K; Jollet M; Oberg SB; Nylen C; Bjornholm M; Rickenlund A; Carlsson M; Caidahl K; Krook A; Pillon NJ; Zierath JR; Wallberg-Henriksson H
- Article: MOLECULAR METABOLISM. 2025;99:102200Smith JAB; Gabriel BM; Brady AJ; Abdelmoez AM; Savikj M; Wright SC; Koutsilieri S; Barres R; Lauschke VM; Krook A; Zierath JR; Pillon NJ
- Article: MOLECULAR METABOLISM. 2025;98:102173Pinto-Hernandez P; Fernandez-Sanjurjo M; Paget D; Caravia XM; Roiz-Valle D; Castilla-Silgado J; Diez-Robles S; Coto-Vilcapoma A; Fernandez-Vivero D; Gama-Perez P; Garcia-Roves PM; Lopez-Otin C; Zierath JR; Krook A; Fernandez-Garcia B; Tomas-Zapico C; Iglesias-Gutierrez E
- Article: CELL. 2025;188(15):4106-4122.e16Kjaergaard J; Stocks B; Henderson J; Freemantle JB; Rizo-Roca D; Puglia M; Montoya MM; Andersson D; Backdahl J; Eriksson-Hogling D; Stidsen JV; Wierer M; Rasmussen S; Sakamoto K; Hojlund K; Ryden M; Zierath JR; Krook A; Deshmukh AS
- Article: SCIENCE ADVANCES. 2025;11(28):eads4371Sen I; Smith JAB; Caria E; Orlov I; Savikj M; Brady AJ; Lian K; Ellefsen S; Zierath JR; Krook A
- Article: MOLECULAR METABOLISM. 2025;92:102081Katayama M; Nomura K; Mudry JM; Chibalin AV; Krook A; Zierath JR
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(768):eado3022Rizo-Roca D; Guimaraes DSPSF; Pendergrast LA; Di Leo N; Chibalin AV; Maqdasy S; Ryden M; Naslund E; Zierath JR; Krook A
- Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347Guimaraes DSPSF; Barrios NMF; de Oliveira AG; Rizo-Roca D; Jollet M; Smith JAB; Araujo TR; da Cruz MV; Marconato E; Hirabara SM; Vieira AS; Krook A; Zierath JR; Silveira LR
- Article: MOLECULAR METABOLISM. 2024;86:101968Nomura K; Kinoshita S; Mizusaki N; Senga Y; Sasaki T; Kitamura T; Sakaue H; Emi A; Hosooka T; Matsuo M; Okamura H; Amo T; Wolf AM; Kamimura N; Ohta S; Itoh T; Hayashi Y; Kiyonari H; Krook A; Zierath JR; Kasuga M; Ogawa W
- Article: NATURE METABOLISM. 2024;6(7):1329-1346Lecoutre S; Maqdasy S; Rizo-Roca D; Renzi G; Vlassakev I; Alaeddine LM; Higos R; Jalkanen J; Zhong J; Zareifi DS; Frendo-Cumbo S; Massier L; Hodek O; Juvany M; Moritz T; de Castro Barbosa T; Omar-Hmeadi M; Lopez-Yus M; Merabtene F; Abatan JB; Marcelin G; El Hachem E-J; Rouault C; Bergo MO; Petrus P; Zierath JR; Clement K; Krook A; Mejhert N; Ryden M
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2024;155:155834Pendergrast LA; Ashcroft SP; Ehrlich AM; Treebak JT; Krook A; Dollet L; Zierath JR
- Article: NATURE METABOLISM. 2024;6(6):1024-1035Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
- Article: CELL REPORTS MEDICINE. 2024;5(1):101348Dollet L; Lundell LS; Chibalin AV; Pendergrast LA; Pillon NJ; Lansbury EL; Elmastas M; Frendo-Cumbo S; Jalkanen J; Barbosa TDC; Cervone DT; Caidahl K; Dmytriyeva O; Deshmukh AS; Barres R; Ryden M; Wallberg-Henriksson H; Zierath JR; Krook A
- Journal article: DIABETES. 2023;72Gattu A; Krook A; Zierath JR; Mann M; Kahn CR
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2023;324(4):E289-E298Abdelmoez AM; Dmytriyeva O; Zurke Y-X; Trauelsen M; Marica AA; Savikj M; Smith JAB; Monaco C; Schwartz TW; Krook A; Pillon NJ
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120Pendergrast LA; Lundell LS; Ehrlich AM; Ashcroft SP; Schoenke M; Basse AL; Krook A; Treebak JT; Dollet L; Zierath JR
- Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598Pillon NJ; Puig LS; Altintas A; Kamble PG; Casani-Galdon S; Gabriel BM; Barres R; Conesa A; Chibalin AV; Naslund E; Krook A; Zierath JR
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All other publications
- Editorial: DIABETOLOGIA. 2026;69(3):537-540Pritlove C; Herder C; Krook A; Mulder H; Sargent JL
- Preprint: BIORXIV. 2025;BIORXIVOlsen L; Botella J; Barrows D; Romero E; Baird K; Katayama M; Kilic E; Peralta C; Sanford H; Farrell L; Axelrod CL; Plucińska K; Walker J; Yan L; Fredrickson K; Pourquie O; Robbins JM; Vinogradova EV; Kirwan JP; Zierath JR; Krook A; Gerszten RE; Bishop DJ; Cohen P
- Conference publication: DIABETOLOGIA. 2025;68:S333-S334Jollet M; Santiago Guimaraes D; Ortiz de Zevallos J; Rizo-Roca D; Bjornholm M; Krook A; Zicrath JR
- Conference publication: DIABETOLOGIA. 2025;68:S118de Zevallos JO; Jollet M; Marica AA; Lehtonen L; Jude B; Lanner JT; Krook A; Zierath JR; Pillon N
- Conference publication: DIABETOLOGIA. 2025;68:S119Stocks B; Ashcroft S; Kjaergaard J; Hansen SSK; Savikj M; Roca DR; Otten J; Olsson T; Rasmussen S; Caidahl K; Wallberg-Henriksson H; Krook A; Deshmukh A; Zierath J
- Conference publication: DIABETOLOGIA. 2025;68:S157Pinto-Hernandez P; Sen I; Pillon N; Zierath JR; Krook A
- Conference publication: DIABETOLOGIA. 2025;68:S339-S340Paget D; Checa A; MacGregor K; Wallberg-Henriksson H; Zierath J; Krook A
- Conference publication: DIABETOLOGIA. 2025;68:S159-S160MacGregor KA; Zierath J; Krook A
- Review: NATURE REVIEWS ENDOCRINOLOGY. 2025;21(3):166-179Macgregor K; Ellefsen S; Pillon NJ; Hammarstroem D; Krook A
- Editorial: DIABETOLOGIA. 2024;67(10):2019-2026Mallik R; Kar P; Mulder H; Krook A
- Conference publication: DIABETOLOGIA. 2024;67:S311Paget D; Checa A; MacGregor K; Wallberg-Henriksson H; Zierath JR; Krook A
- Conference publication: DIABETOLOGIA. 2024;67:S76MacGregor K; Zierath J; Krook A
- Conference publication: DIABETOLOGIA. 2024;67:S252Yu X; Krook A; Zierath JR; Pillon NJ
- Preprint: BIORXIV. 2024Pinto-Hernandez P; Fernandez-Sanjurjo M; Paget D; Caravia X; Roiz-Valle D; Castilla-Silgado J; Diez-Robles S; Coto-Vilcapoma A; Gama P; Garcia-Roves P; Lopez-Otin C; Zierath J; Krook A; Fernandez-Garcia B; Tomas-Zapico C; Iglesias-Gutierrez E
- Preprint: BIORXIV. 2024Smith JAB; Gabriel B; Abdelmoez A; Savikj M; Wright S; Koutsilieri S; Barrès R; Lauschke V; Krook A; Zierath J; Pillon N
- Preprint: BIORXIV. 2024Larsen JK; Stocks B; Henderson J; Andersson D; Bäckdahl J; Eriksson-Hogling D; Stidsen JV; Sakamoto K; Højlund K; Rydén M; Zierath JR; Krook A; Deshmukh AS
- Preprint: BIORXIV. 2024Rizo-Roca D; Guimarães DSPSF; Pendergrast L; Di Leo N; Chibalin A; Maqdasy S; Rydén M; Näslund E; Zierath J; Krook A
- Editorial: DIABETOLOGIA. 2023;66(10):1762-1764Krook A; Mulder H
- Preprint: BIORXIV. 2023Jiang S; Yuan T; Kremer LS; Rosenberger FA; Hansen FM; Borg M; Rubalcava-Gracia D; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
- Conference publication: ACTA PHYSIOLOGICA. 2023;239Jude B; Tagadirt L; Santos-Alves E; Mader T; Chibalin AV; Ducommun S; Zierath JR; Von Walden F; Krook A; Ruas JL; Lanner JT
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Grants
- Novo Nordisk Foundation1 August 2024 - 31 July 2029
- Genomic plasticity and metabolic memory of skeletal muscle insulin resistanceWenner-Gren Foundation15 March 2024 - 31 August 2025
- Swedish Research Council1 January 2023 - 31 December 2026The dysregulated glucose control distinctive of type 2 diabetes is a result of relative insulin deficiency, where insulin producing beta cells are unable to compensate insulin resistance evident in peripheral tissues such as skeletal muscle. Increased prevalence is partly driven by changes in lifestyle, however, there is a strong genetic component to type 2 diabetes. The overarching aim of my research is to understand the molecular regulation of the impaired insulin response and altered metabolism in skeletal muscle from people with type 2 diabetes. I hypothesize that dysregulation of non-coding RNA plays a key role in the regulation of skeletal muscle health with respect to metabolism and insulin sensitivity. Although all cells in a mammal share the same genome, ~80% of DNA is transcribed in a cell-specific manner, and this is particularly true for regions not coding for protein transcripts. Several different classes of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), play key roles in skeletal muscle myogenesis including satellite cell activation, proliferation, and differentiation, however only a few transcripts have been studied, particularly in the context of metabolic disease. Thus, to understand the role of non-coding RNA in regulation of metabolism, and the role played in metabolic disease is the aim of this research programme.
- Swedish Research Council1 January 2019 - 31 December 2022
- Knut and Alice Wallenberg Foundation1 January 2018 - 1 January 2021
- Swedish Research Council1 January 2013 - 31 December 2017
- Swedish Research Council1 January 2009 - 31 December 2013
Employments
- Professor, Integrative Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, 2010-
Degrees and Education
- Docent, Karolinska Institutet, 2002
Distinction and awards
- The DPLU/LUDC Nordic Prize, DPLU/LUDC, 2013