Anna Krook
About me
I am a Professor of Integrative Physiology at the Department of Physiology and Pharmacology and chair of the Strategic Research Programme in Diabetes at Karolinska Institutet. (Photo credit Yanan Li)
Link to https://ki.se/en/srp-diabetes/strategic-research-programme-in-diabetes-srp-diabetes
Education
Bachelor of Science (Class I, Hons), Biological Sciences, University of East Anglia, United KingdomMaster of Science, Department of Pathology, Queens University, Canada
Doctor of Philosophy, School of Clinical Medicine, University of Cambridge, United Kingdom
Research
I completed my doctoral studies at the University of Cambridge, UK, focusing on insulin receptor mutations in patients with severe syndromes of insulin resistance. Since then my research interest is focused on understanding insulin action at the molecular level. Work in my research group is currently focused on three broad areas, all centred around skeletal muscle metabolism. These include understanding the role non-coding RNA directs muscle metabolism and insulin sensitivity, transcriptional regulation of skeletal muscle metabolism and the effects of metabolites, hormones and other circulatory factors. We are interested in how insulin sensitivity and glucose metabolism are affected by type 2 diabetes and by exercise, both at the cellular level and by studying people with or without type 2 diabetes after various exercise interventions.
Link to the research group home page is here: https://ki.se/en/fyfa/integrative-physiology
Teaching
I am course director for the 15 credit course in the Master's Programme in Translational Physiology and Pharmacology, given in the spring every year. Please find link below: https://education.ki.se/student/physiological-and-pharmacological-mechanisms-and-experimental-approaches-15-credits/4ff002
Articles
- Article: MOLECULAR METABOLISM. 2024;86:101968
- Article: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE. 2024;15(4):1335-1347
- Article: NATURE METABOLISM. 2024;6(6):1024-1035
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2024;155:155834
- Article: CELL REPORTS MEDICINE. 2024;5(1):101348
- Journal article: DIABETES. 2023;72(Supplement_1)
- Article: NATURE REVIEWS ENDOCRINOLOGY. 2023;19(5):250-251
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2023;324(4):E289-E298
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120
- Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598
- Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2022;135:155268
- Article: SCIENCE ADVANCES. 2022;8(36):eabo3192
- Article: NATURE GENETICS. 2022;54(9):1332-1344
- Article: DIABETES. 2022;71(4):624-636
- Article: NATURE METABOLISM. 2022;4(2):190-202
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;321(5):C770-C778
- Article: SCIENCE ADVANCES. 2021;7(43):eabi9654
- Article: NATURE COMMUNICATIONS. 2021;12(1):5948
- Article: DIABETOLOGIA. 2021;64(9):2077-2091
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2021;321(2):E203-E216
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2021;118:154726
- Article: SCIENCE ADVANCES. 2021;7(11):eabc2931
- Article: CELL METABOLISM. 2020;32(5):844-859.e5
- Article: OBESITY. 2020;28(Suppl 1):S38-S45
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2020;105(6):dgaa165-2041
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2020;318(3):C615-C626
- Article: CELL METABOLISM. 2020;31(2):375-390.e11
- Article: NATURE COMMUNICATIONS. 2020;11(1):470
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2020;318(1):E1-E10
- Article: THE FASEB JOURNAL. 2019;33(9):10551-10562
- Article: DIABETES. 2019;68(7):1403-1414
- Article: THE FASEB JOURNAL. 2019;33(5):6269-6280
- Article: JOURNAL OF NUTRITION AND METABOLISM. 2019;2019:1840374-8
- Article: DIABETES. 2019;68(3):515-526
- Article: MOLECULAR METABOLISM. 2019;20:79-88
- Article: DIABETOLOGIA. 2019;62(2):233-237
- Article: ANALYTICA CHIMICA ACTA. 2018;1037:338-350
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2018;103(12):4465-4477
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2018;315(5):E995-E1004
- Article: MOLECULAR METABOLISM. 2018;16:12-23
- Article: JOURNAL OF OBESITY. 2018;2018:7461903-8
- Article: ACTA PHYSIOLOGICA. 2018;223(3):e13051
- Article: PHYSIOLOGICAL REPORTS. 2018;6(12):e13739
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(9):E2048-E2057
- Article: DIABETOLOGIA. 2018;61(2):424-432
- Article: EXPERIMENTAL CELL RESEARCH. 2017;360(1):47-54
- Article: MOLECULAR METABOLISM. 2017;6(7):621-630
- Article: DIABETES. 2017;66(7):1807-1818
- Article: DIABETES. 2017;66(3):651-662
- Article: PLOS ONE. 2017;12(4):e0175441
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1861(12):2130-2138
- Article: PLOS MEDICINE. 2016;13(11):e1002179
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761
- Article: MOLECULAR METABOLISM. 2016;5(3):171-183
- Article: MOLECULAR METABOLISM. 2016;5(3):184-197
- Article: BIOCHEMICAL JOURNAL. 2015;472(2):147-156
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(6):643-655
- Article: DIABETES AND VASCULAR DISEASE RESEARCH. 2015;12(5):315-324
- Article: DIABETES CARE. 2015;38(6):1154-1160
- Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2015;11(3):592-601
- Article: PHYSIOLOGICAL GENOMICS. 2015;47(3):45-57
- Article: JOURNAL OF ENDOCRINOLOGY. 2015;224(3):303-313
- Article: CELL. 2014;159(1):33-45
- Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2014;10(4):671-678
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1359-E1366
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2013;305(9):E1071-E1080
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2013;712(1-3):16-21
- Article: CELL REPORTS. 2013;3(4):1020-1027
- Article: DIABETES. 2013;62(2):355-361
- Article: DIABETES. 2013;62(2):457-465
- Article: PLOS ONE. 2013;8(4):e61903
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2013;29(1):25-32
- Article: CELL METABOLISM. 2012;15(3):405-411
- Article: METABOLISM: CLINICAL AND EXPERIMENTAL. 2012;61(2):175-185
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(40):34567-34574
- Article: MEDICAL CLINICS OF NORTH AMERICA. 2011;95(5):953-969
- Article: DIABETES. 2011;60(8):2061-2067
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2011;110(5):1204-1210
- Article: DIABETES. 2011;60(3):925-935
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2011;27(3):286-297
- Article: THROMBOSIS AND HAEMOSTASIS. 2011;105(1):122-130
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2010;95(5):2359-2366
- Article: CELL METABOLISM. 2009;10(3):189-198
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2009;25(3):250-258
- Article: DIABETES. 2008;57(8):2066-2073
- Article: DIABETES. 2008;57(6):1508-1516
- Article: CELL. 2008;132(3):375-386
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(27):19313-19320
- Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2007;2(4):477-485
- Article: DIABETES. 2007;56(6):1630-1637
- Article: PLOS MEDICINE. 2007;4(5):e158-879
- Article: MOLECULAR ENDOCRINOLOGY. 2006;20(12):3364-3375
- Article: ACTA PHYSIOLOGICA. 2006;188(3-4):207-216
- Article: DIABETES/METABOLISM RESEARCH AND REVIEWS. 2006;22(6):492-498
- Article: CELL METABOLISM. 2006;4(1):89-96
- Article: CYTOTECHNOLOGY. 2005;48(1-3):89-95
- Article: DIABETES. 2005;54(6):1692-1697
- Article: DIABETES. 2005;54(4):1157-1163
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;287(3):E553-E557
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(24):25211-25218
- Article: DIABETES. 2004;53(6):1424-1428
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2004;286(6):C1410-C1416
- Article: ACTA PHYSIOLOGICA. 2004;180(4):395-403
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2004;286(2):E194-E200
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(1):127-132
- Article: JOURNAL OF PHYSIOLOGY. 2003;550(1):305-315
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(5):991-998
- Article: JOURNAL OF PHYSIOLOGY. 2003;546(2):327-335
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2003;23(1):21-30
- Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259
- Article: JOURNAL OF PHYSIOLOGY. 2001;536(1):273-282
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34
- Article: BIOCHEMICAL JOURNAL. 2000;351(Pt 3):805-810
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721
- Article: DIABETES. 2000;49(2):284-292
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43
- Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;277(6):R1690-R1696
- Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330
- Article: DIABETOLOGIA. 1999;42(7):826-830
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142
- Article: DIABETES. 1999;48(3):664-670
- Article: THE FASEB JOURNAL. 1998;12(13):1379-1389
- Article: DIABETES. 1998;47(9):1528-1531
- Article: DIABETES. 1998;47(8):1281-1286
- Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160
- Article: DIABETES. 1997;46(12):2110-2114
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(48):30208-30214
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(43):26833-26840
- Article: DIABETIC MEDICINE. 1997;14(3):228-234
- Journal article: APMIS. 1997;105(3):213-220
- Article: THE LANCET. 1996;347(9015):1586-1590
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 1996;81(5):1979-1983
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(12):7134-7140
- Journal article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES. 1995;14(4):297-304
- Journal article: DIABETES. 1994;43(3):357-368
- Journal article: THE LANCET. 1993;342(8866):277-278
- Journal article: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES. 1993;12(4):289-293
- Journal article: DIABETOLOGIA. 1992;35(5):486-489
- Journal article: JOURNAL OF VIROLOGY. 1991;65(10):5203-5210
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All other publications
- Preprint: BIORXIV. 2024
- Preprint: BIORXIV. 2024
- Editorial comment: DIABETOLOGIA. 2023;66(10):1762-1764
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839.1-83839
- Conference publication: ACTA PHYSIOLOGICA. 2023;239
- Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S79-S80
- Editorial comment: DIABETOLOGIA. 2022;65(11):1755-1757
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S84-S85
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S42-S43
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S121-S122
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S121
- Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(1):37-49
- Conference publication: FASEB JOURNAL. 2017;31
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:7
- Conference publication: DIABETOLOGIA. 2016;59:S325
- Conference publication: DIABETOLOGIA. 2016;59:S170
- Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2016;12(1):7-8
- Editorial comment: DIABETOLOGIA. 2016;59(1):5-8
- Corrigendum: JOURNAL OF ENDOCRINOLOGY. 2015;226(3):X1
- Conference publication: DIABETOLOGIA. 2015;58:S300
- Editorial comment: DIABETES. 2014;63(4):1169-1170
- Conference publication: ACTA PHYSIOLOGICA. 2014;211:33
- Corrigendum: CELL REPORTS. 2013;3(5):1755
- Review: TRENDS IN CELL BIOLOGY. 2013;23(5):203-209
- Editorial comment: DIABETES. 2013;62(4):1024-1025
- Editorial comment: DIABETOLOGIA. 2012;55(10):2562-2564
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A32
- Editorial comment: JOURNAL OF ENDOCRINOLOGY. 2011;211(1):1-2
- Corrigendum: JOURNAL OF APPLIED PHYSIOLOGY. 2011;111(2):622
- Conference publication: EUROPEAN HEART JOURNAL. 2011;32:331
- Review: LAKARTIDNINGEN. 2010;107(45):2802-2805
- Conference publication: DIABETOLOGIA. 2010;53
- Conference publication: DIABETOLOGIA. 2010;53:S43
- Conference publication: DIABETOLOGIA. 2010;53
- Conference publication: DIABETOLOGIA. 2010;53:S80
- Review: PHARMACOLOGICAL REVIEWS. 2009;61(3):373-393
- Review: DIABETOLOGIA. 2009;52(7):1231-1239
- Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2009;10(2)
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:80
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:647
- Review: ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA. 2008;37(4):887-903
- Editorial comment: DIABETOLOGIA. 2008;51(7):1097-1099
- Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2008;70:11
- Published conference paper: ACTA PHYSIOLOGICA. 2008;192(1):37-48
- Corrigendum: ACTA PHYSIOLOGICA. 2007;189(1):101
- Editorial comment: DIABETOLOGIA. 2006;49(5):819-821
- Conference publication: DIABETOLOGIA. 2006;49:22
- Conference publication: DIABETOLOGIA. 2006;49:21-22
- Conference publication: DIABETOLOGIA. 2006;49:411
- Review: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES. 2003;111(4):191-197
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;986:449-452
- Conference publication: DIABETOLOGIA. 2002;45:A271
- Conference publication: DIABETOLOGIA. 2002;45:A189-A190
- Conference publication: DIABETOLOGIA. 2002;45:A22
- Review: DIABETOLOGIA. 2000;43(7):821-835
- Conference publication: INTERNATIONAL JOURNAL OF PSYCHOLOGY. 2000;35(3-4):13
- Conference publication: DIABETOLOGIA. 2000;43:A87
- Conference publication: DIABETOLOGIA. 1999;42:A178
- Conference publication: DIABETES. 1999;48:A22
- Conference publication: DIABETOLOGIA. 1999;42:A178
- Conference publication: DIABETOLOGIA. 1999;42:A178
- Conference publication: DIABETOLOGIA. 1999;42:A171
- Conference publication: DIABETOLOGIA. 1998;41:A189
- Conference publication: DIABETOLOGIA. 1998;41:A11
- Conference publication: DIABETES. 1998;47:A237
- Conference publication: DIABETOLOGIA. 1998;41:A263
- Conference publication: DIABETES. 1998;47:A4
- Review: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. 1997;90(9):557-562
- Conference publication: DIABETOLOGIA. 1997;40:148
- Editorial comment: CLINICAL ENDOCRINOLOGY. 1996;45(2):237-238
- Conference publication: DIABETES. 1996;45:1284
- Published conference paper: QUARTERLY JOURNAL OF MEDICINE. 1996;89(11):874
- Review: BAILLIERE'S CLINICAL ENDOCRINOLOGY AND METABOLISM. 1996;10(1):97-122
- Other: NEW ENGLAND JOURNAL OF MEDICINE. 1995;333(21):1386-1390
- Other: PRENATAL DIAGNOSIS. 1995;15(7):669-671
- Conference publication: DIABETOLOGIA. 1995;38:A69
- Conference publication: DIABETOLOGIA. 1995;38:A65
- Conference publication: DIABETES. 1995;44:A244
- Conference publication: DIABETES. 1995;44:A142
- Conference publication: DIABETES. 1995;44:A84
- Conference publication: JOURNAL OF MEDICAL GENETICS. 1994;31(2):170
- Conference publication: DIABETOLOGIA. 1993;36:A52
- Conference publication: DIABETOLOGIA. 1993;36:A4
- Conference publication: DIABETES. 1993;42:A95
- Conference publication: JOURNAL OF ENDOCRINOLOGY. 1992;135:O37
- Conference publication: DIABETOLOGIA. 1992;35:A71
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Grants
- Genomic plasticity and metabolic memory of skeletal muscle insulin resistanceWenner-Gren Foundation15 March 2024
- Swedish Research Council1 January 2023 - 31 December 2026
- Swedish Research Council1 January 2019 - 31 December 2022
- Knut and Alice Wallenberg Foundation1 January 2018 - 1 January 2021
- Swedish Research Council1 January 2013 - 31 December 2017
- Swedish Research Council1 January 2009 - 31 December 2013
Employments
- Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2010-
Degrees and Education
- Docent, Karolinska Institutet, 2002
Distinction and awards
- The DPLU/LUDC Nordic Prize, DPLU/LUDC, 2013