Andrea Varrone

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Professor i i molekylär positronemissionstomografi vid institutionen för klinisk neurovetenskap, Karolinska Institutet sedan 4 september 2023.

För mer information om Andrea Varrones karriär och forskning se
den engelska profilsidan.

Artiklar

Article: ACS CHEMICAL NEUROSCIENCE. 2024;15(10):2018-2027

Exploring the Interactions between two Ligands, UCB-J and UCB-F, and Synaptic Vesicle Glycoprotein 2 Isoforms

Li J; Zou R; Varrone A; Nag S; Halldin C; Agren H
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(20):3732-3736

Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [¹⁸F]FE-PE2I-OH for Translational Dopamine Transporter Imaging

Schou M; Amini N; Takano A; Arakawa R; Dahl K; Toth M; Svedberg M; Varrone A; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(7):1206-1215

Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [¹¹C]PE2I, [¹⁸F]FE-PE2I and [¹¹C]raclopride PET in healthy individuals

Jonasson M; Frick A; Fazio P; Hjorth O; Danfors T; Axelsson J; Appel L; Furmark T; Varrone A; Lubberink M
Article: MOVEMENT DISORDERS. 2023;38(7):1209-1222

Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial

Huttunen HJJ; Booms S; Sjogren M; Kerstens V; Johansson J; Holmnas R; Koskinen J; Kulesskaya N; Fazio P; Woolley M; Brady A; Williams J; Johnson D; Dailami N; Gray W; Levo R; Saarma M; Halldin C; Marjamaa J; Resendiz-Nieves J; Grubor I; Lind G; Eerola-Rautio J; Mertsalmi T; Andreasson M; Paul G; Rinne J; Kivisaari R; Bjartmarz H; Almqvist P; Varrone A; Scheperjans F; Widner H; Svenningsson P
Article: CTS-CLINICAL AND TRANSLATIONAL SCIENCE. 2023;16(6):955-965

Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non-small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study

Ekman S; Cselenyi Z; Varrone A; Jucaite A; Martin H; Schou M; Johnstrom P; Laus G; Lewensohn R; Brown AP; van der Aart J; Vishwanathan K; Farde L
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248

Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [¹¹C]AZ10419369 Positron Emission Tomography Study

Tangen A; Veldman ER; Svensson J; Tiger M; Nord M; Sorjonen K; Andersson M; Plaven-Sigray P; Varrone A; Halldin C; Varnas K; Borg J; Lundberg J
Article: EJNMMI RESEARCH. 2023;13(1):29

[¹⁸F]FE-PE2I DAT correlates with Parkinson's disease duration, stage, and rigidity/bradykinesia scores: a PET radioligand validation study

Kerstens VS; Fazio P; Sundgren M; Halldin C; Svenningsson P; Varrone A
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(2):258-268

Quantification of the purinergic P2X₇ receptor with [¹¹C]SMW139 improves through correction for brain-penetrating radiometabolites

Brumberg J; Aarnio R; Forsberg A; Marjamaki P; Kerstens V; Moein MM; Nag S; Wahlroos S; Kassiou M; Windhorst AD; Halldin C; Haaparanta-Solin M; Fazio P; Oikonen V; Rinne JO; Varrone A
Journal article: ACS CHEMICAL NEUROSCIENCE. 2023;14(1):111-118

Characterization of the Novel P2X7 Receptor Radioligand [3H]JNJ-64413739 in Human Brain Tissue

Mikkelsen JD; Aripaka SS; Kaad S; Pazarlar BA; Pinborg L; Finsen B; Varrone A; Bang-Andersen B; Bastlund JF
Article: NEUROIMAGE-CLINICAL. 2023;37:103347

Longitudinal DAT changes measured with [18F]FE-PE2I PET in patients with Parkinson?s disease; a validation study

Kerstens VS; Fazio P; Sundgren M; Brumberg J; Halldin C; Svenningsson P; Varrone A
Article: JOURNAL OF NUCLEAR MEDICINE. 2022;63(12):1919-1924

First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B

Wakabayashi Y; Stenkrona P; Arakawa R; Yan X; Van Buskirk MG; Jenkins MD; Santamaria JAM; Maresca KP; Takano A; Liow J-S; Chappie TA; Varrone A; Nag S; Zhang L; Hughes ZA; Schmidt CJ; Doran SD; Mannes A; Zanotti-Fregonara P; Ooms M; Morse CL; Zoghbi SS; Halldin C; Pike VW; Innis RB
Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2022;108:s26

O-37 Synthesis and biological evaluation of a novel radioligand [11C] BIO-1790735 for detection of O-GlcNAcase (OGA) enzyme activity

Nag S; Arakawa R; Datta P; Morén A; Varrone A; Moein MM; Bolin M; Lin E; Genung N; Martarello L; Kaliszczak M; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022;42(4):630-641

Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography

Veldman ER; Varrone A; Varnas K; Svedberg MM; Cselenyi Z; Tiger M; Gulyas B; Halldin C; Lundberg J
Journal article: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2022;111(4):774-785

PET as a Translational Tool in Drug Development for Neuroscience Compounds

Varrone A; Bundgaard C; Bang-Andersen B
Article: NUCLEAR MEDICINE COMMUNICATIONS. 2022;43(3):247-255

VNTR polymorphism in the SLC6A3 gene does not influence dopamine transporter availability measured by [¹⁸F]FE-PE2I PET or [¹²³I]FP-Cit SPECT

Mo SJ; Axelsson J; Stiernman LJ; Larsson A; Af Bjerken S; Backstrom D; Kellgren TG; Varrone A; Riklund K
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;49(2):632-651

EANM procedure guidelines for brain PET imaging using [¹⁸F]FDG, version 3

Guedj E; Varrone A; Boellaard R; Albert NL; Barthel H; van Berckel B; Brendel M; Cecchin D; Ekmekcioglu O; Garibotto V; Lammertsma AA; Law I; Penuelas I; Semah F; Traub-Weidinger T; van de Giessen E; Van Weehaeghe D; Morbelli S
Article: MOVEMENT DISORDERS. 2022;37(1):119-129

Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [¹¹C]PBR28 and Machine Learning Analysis

Jucaite A; Cselenyi Z; Kreisl WC; Rabiner EA; Varrone A; Carson RE; Rinne JO; Savage A; Schou M; Johnstrom P; Svenningsson P; Rascol O; Meissner WG; Barone P; Seppi K; Kaufmann H; Wenning GK; Poewe W; Farde L
Article: ACS CHEMICAL NEUROSCIENCE. 2021;12(24):4580-4586

PET Imaging of VMAT2 with the Novel Radioligand [¹⁸F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [¹¹C]DTBZ and [¹⁸F]FE-DTBZ

Nag S; Jahan M; Toth M; Nakao R; Varrone A; Halldin C
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2021;64(16):12003-12021

[¹¹C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Liu L; Johnson PD; Prime ME; Khetarpal V; Lee MR; Brown CJ; Chen X; Clark-Frew D; Coe S; Conlon M; Davis R; Ensor S; Esposito S; Moren AF; Gai X; Green S; Greenaway C; Haber J; Halldin C; Hayes S; Herbst T; Herrmann F; He-mann M; Hsai MM; Kotey A; Mangette JE; Mills MR; Monteagudo E; Nag S; Nibbio M; Orsatti L; Schaertl S; Scheich C; Sproston J; Stepanov V; Varnas K; Varrone A; Wityak J; Mrzljak L; Munoz-Sanjuan I; Bard JA; Dominguez C
Article: EJNMMI RESEARCH. 2021;11(1):82

Sex correction improves the accuracy of clinical dopamine transporter imaging

Honkanen EA; Noponen T; Hirvilammi R; Lindholm K; Parkkola R; Joutsa J; Varrone A; Kaasinen V
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(6):1291-1300

Simplified quantification of [¹⁸F]FE-PE2I PET in Parkinson's disease: Discriminative power, test-retest reliability and longitudinal validity during early peak and late pseudo-equilibrium

Brumberg J; Kerstens V; Cselenyi Z; Svenningsson P; Sundgren M; Fazio P; Varrone A
Article: NEURO-ONCOLOGY. 2021;23(4):687-696

Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study

Jucaite A; Stenkrona P; Cselenyi Z; De Vita S; Buil-Bruna N; Varnas K; Savage A; Varrone A; Johnstrom P; Schou M; Davison C; Sykes A; Reddy VP; Hoch M; Vazquez-Romero A; Moein MM; Halldin C; Merchant MS; Pass M; Farde L
Journal article: JOURNAL OF THORACIC ONCOLOGY. 2021;16(3):s620

P76.72 A PET and MRI Study Exploring Osimertinib Brain Exposure and Efficacy in EGFRm NSCLC CNS Metastases

Ekman S; Cselényi Z; Varrone A; Jucaite A; Martin H; Schou M; Johnström P; Laus G; Lewensohn R; Brown A; Van Der Aart J; Vishwanathan K; Farde L
Article: JOURNAL OF NUCLEAR MEDICINE. 2021;62(3):412-417

Nondisplaceable Binding Is a Potential Confounding Factor in ¹¹C-PBR28 Translocator Protein PET Studies

Laurell GL; Plaven-Sigray P; Jucaite A; Varrone A; Cosgrove KP; Svarer C; Knudsen GM; Ogden RT; Zanderigo F; Cervenka S; Hillmer AT; Schain M
Article: NEUROIMAGE-CLINICAL. 2021;32:102807

Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials

Honkanen EA; Eklund M; Nuuttila S; Noponen T; Jaakkola E; Makinen E; Hirvilammi R; Seppanen M; Lindholm K; Scheperjans F; Parkkola R; Joutsa J; Varrone A; Kaasinen V
Article: BRAIN RESEARCH. 2020;1749:147131

Identification and in vitro characterization of C05-01, a PBB3 derivative with improved affinity for alpha-synuclein

Miranda-Azpiazu P; Svedberg M; Higuchi M; Ono M; Jia Z; Sunnemark D; Elmore CS; Schou M; Varrone A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(10):2407-2416

High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson's disease cohort

Fazio P; Ferreira D; Svenningsson P; Halldin C; Farde L; Westman E; Varrone A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(10):2429-2439

PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [¹⁸F]PF-06684511

Arakawa R; Takano A; Stenkrona P; Stepanov V; Nag S; Jahan M; Gryback P; Bolin M; Chen L; Zhang L; He P; Villalobos A; McCarthy TJ; Halldin C; Varrone A
Article: EJNMMI RESEARCH. 2020;10(1):95

Reliability of dopamine transporter PET measurements with [¹⁸F]FE-PE2I in patients with Parkinson's disease

Kerstens VS; Fazio P; Sundgren M; Matheson GJ; Franzen E; Halldin C; Cervenka S; Svenningsson P; Varrone A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(8):1885-1912

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

Morbelli S; Esposito G; Arbizu J; Barthel H; Boellaard R; Bohnen NI; Brooks DJ; Darcourt J; Dickson JC; Douglas D; Drzezga A; Dubroff J; Ekmekcioglu O; Garibotto V; Herscovitch P; Kuo P; Lammertsma A; Pappata S; Penuelas I; Seibyl J; Semah F; Tossici-Bolt L; Van de Giessen E; Van Laere K; Varrone A; Wanner M; Zubal G; Law I
Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(8):1787-1790

Proven validity and management impact of amyloid imaging in Alzheimer's disease-repetita juvant

Barthel H; Arbizu J; Drzezga A; Garibotto V; Lammertsma AA; Morbelli S; Albert N; Albert N; Boellaard R; Cecchin D; Ekmekcioglu O; Guedj E; Law I; Penuelas I; Semah F; Traub-Weidinger T; van de Giessen E; Varrone A
Article: EJNMMI RESEARCH. 2020;10(1):59

Quantification and reliability of [¹¹C]VC-002 binding to muscarinic acetylcholine receptors in the human lung - a test-retest PET study in control subjects

Cselenyi Z; Jucaite A; Kristensson C; Stenkrona P; Ewing P; Varrone A; Johnstrom P; Schou M; Vazquez-Romero A; Moein MM; Bolin M; Siikanen J; Gryback P; Larsson B; Halldin C; Grime K; Eriksson UG; Farde L
Article: MOVEMENT DISORDERS. 2020;35(4):606-615

PET molecular imaging of phosphodiesterase 10A: An early biomarker of Huntington's disease progression

Fazio P; Fitzer-Attas CJ; Mrzljak L; Bronzova J; Nag S; Warner JH; Landwehrmeyer B; Al-Tawil N; Halldin C; Forsberg A; Ware J; Dilda V; Wood A; Sampaio C; Varrone A; Svenningsson P; Paucar M; Sundblom J; Nyholm D; Widner H; Heiberg A; Frich J; Nielsen J; Hjermind L; Roos R
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2020;40(4):799-807

A PET study in healthy subjects of brain exposure of ¹¹C-labelled osimertinib - A drug intended for treatment of brain metastases in non-small cell lung cancer

Varrone A; Varnas K; Jucaite A; Cselenyi Z; Johnstrom P; Schou M; Vazquez-Romero A; Moein MM; Halldin C; Brown AP; Vishwanathan K; Farde L
Article: TALANTA. 2020;208:120449

New approach in radiometabolite analysis of positron emission tomography (PET) radioligands; lead-shielded microextraction by packed sorbent as a tool for in vivo radiometabolite analysis of [¹¹C]SMW139 in rat plasma

Moein MM; Toth M; Tari L; Varrone A; Abdel-Rehim M; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2019;60(12):1818-1824

Performance Evaluation of a High-Resolution Nonhuman Primate PET/CT System

Sarnyai Z; Nagy K; Patay G; Molnar M; Rosenqvist G; Toth M; Takano A; Gulyas B; Major P; Halldin C; Varrone A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338

Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [¹¹C]PBR28 HRRT PET study

Tuisku J; Plaven-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Bruck A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamaki P; Rissanen E; Sucksdorff M; Varrone A; Collste K; Gallezot J-D; Hillmer A; Huang Y; Hoglund CO; Johansson J; Jucaite A; Lampa J; Nabulsi N; Pittman B; Sandiego CM; Stenkrona P; Rinne J; Matuskey D; Cervenka S
Article: ALZHEIMERS & DEMENTIA. 2019;15(8):1081-1103

A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies

Perani D; Iaccarino L; Lammertsma AA; Windhorst AD; Edison P; Boellaard R; Hansson O; Nordberg A; Jacobs AH
Article: NATURE MEDICINE. 2019;25(7):1131-1142

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease

Zeitler B; Froelich S; Marlen K; Shivak DA; Yu Q; Li D; Pearl JR; Miller JC; Zhang L; Paschon DE; Hinkley SJ; Ankoudinova I; Lam S; Guschin D; Kopan L; Cherone JM; Nguyen H-OB; Qiao G; Ataei Y; Mendel MC; Amora R; Surosky R; Laganiere J; Vu BJ; Narayanan A; Sedaghat Y; Tillack K; Thiede C; Gaertner A; Kwak S; Bard J; Mrzljak L; Park L; Heikkinen T; Lehtimaki KK; Svedberg MM; Haggkvist J; Tari L; Toth M; Varrone A; Halldin C; Kudwa AE; Ramboz S; Day M; Kondapalli J; Surmeier DJ; Urnov FD; Gregory PD; Rebar EJ; Munoz-Sanjuan I; Zhang HS
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2019;62(6):265-279

Synthesis, ³H-labelling and in vitro evaluation of a substituted dipiperidine alcohol as a potential ligand for chemokine receptor 2

Artelsmair M; Miranda-Azpiazu P; Kingston L; Bergare J; Schou M; Varrone A; Elmore CS
Article: BRAIN RESEARCH. 2019;1711:140-145

In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [¹⁸F]MNI-659

Svedberg MM; Varnas K; Varrone A; Mitsios N; Mulder J; Gulyas B; Beaumont V; Munoz-Sanjuan I; Zaleska MM; Schmidt CJ; Halldin C; Mrzljak L
Article: NEUROIMAGE. 2019;188:102-110

Accuracy and reliability of [¹¹C]PBR28 specific binding estimated without the use of a reference region

Plaven-Sigray P; Schain M; Zanderigo F; Farde L; Halldin C; Forsberg A; Varrone A; Jucaite A; Cervenka S; Stenkrona P; Collste K; Kander M; Kosek E; Lampa J; Hoglund CO; Rabiner EA; Gunn RN; Ogden RT; Cervenk S
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(2):367-375

PET imaging of [¹¹C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

Varnas K; Cselenyi Z; Jucaite A; Halldin C; Svenningsson P; Farde L; Varrone A
Article: ACS CHEMICAL NEUROSCIENCE. 2018;9(11):2542-2547

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy

Cairns AG; Vazquez-Romero A; Moein MM; Aden J; Elmore CS; Takano A; Arakawa R; Varrone A; Almqvist F; Schou M
Article: EJNMMI RESEARCH. 2018;8(1):100

Dopamine transporter imaging with [¹⁸F]FE-PE2I PET and [¹²³I]FP-CIT SPECTa clinical comparison

Mo SJ; Axelsson J; Jonasson L; Larsson A; Ogren MJ; Ogren M; Varrone A; Eriksson L; Backstrom D; af Bjerken S; Linder J; Riklund K
Article: JOURNAL OF NUCLEAR MEDICINE. 2018;59(8):1275-1280

Whole-Body Biodistribution and Dosimetry of the Dopamine Transporter Radioligand ¹⁸F-FE-PE2I in Human Subjects

Lizana H; Johansson L; Axelsson J; Larsson A; Ogren M; Linder J; Halldin C; Varrone A; Mo SJ
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45(9):1605-1617

Dual tracer tau PET imaging reveals different molecular targets for ¹¹C-THK5351 and ¹¹C-PBB3 in the Alzheimer brain

Chiotis K; Stenkrona P; Almkvist O; Stepanov V; Ferreira D; Arakawa R; Takano A; Westman E; Varrone A; Okamura N; Shimada H; Higuchi M; Halldin C; Nordberg A
Article: MOVEMENT DISORDERS. 2018;33(4):592-599

Nigrostriatal dopamine transporter availability in early Parkinson's disease

Fazio P; Svenningsson P; Cselenyi Z; Halldin C; Farde L; Varrone A
Article: EJNMMI RESEARCH. 2017;7(1):58

Assessment of simplified ratio-based approaches for quantification of PET [¹¹C] PBR28 data

Matheson GJ; Plaven-Sigray P; Forsberg A; Varrone A; Farde L; Cervenka S
Article: EJNMMI PHYSICS. 2017;4(1):8

[¹²³I] FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods

Tossici-Bolt L; Dickson JC; Sera T; Booij J; Asenbaun-Nan S; Bagnara MC; Borght TV; Jonsson C; de Nijs R; Hesse S; Koulibaly PM; Akdemir UO; Koole M; Tatsch K; Varrone A
Article: EJNMMI RESEARCH. 2017;7(1):10

The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [¹²³I]FP-CIT SPECT imaging

Dickson JC; Tossici-Bolt L; Sera T; Booij J; Ziebell M; Morbelli S; Assenbaum-Nan S; Vander Borght T; Pagani M; Kapucu OL; Hesse S; Van Laere K; Darcourt J; Varrone A; Tatsch K
Article: EJNMMI RESEARCH. 2017;7(1):66

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue

Schain M; Fazio P; Mrzljak L; Amini N; Al-Tawil N; Fitzer-Attas C; Bronzova J; Landwehrmeyer B; Sampaio C; Halldin C; Varrone A
Journal article: ALZHEIMERS & DEMENTIA. 2017;13(7S_Part_15):p765

[P2–366]: HEAD‐TO‐HEAD IN VIVO COMPARISON OF TAU‐SPECIFIC PET TRACERS IN ALZHEIMER's DISEASE: [11C]THK5351 VERSUS [11C]PBB3 PET IMAGING

Chiotis K; Stenkrona P; Almkvist O; Arakawa R; Takano A; Stepanov V; Varrone A; Higuchi M; Halldin C; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2017;13(7S_Part_2):p133

[IC‐P‐178]: HEAD‐TO‐HEAD IN VIVO COMPARISON OF TAU‐SPECIFIC PET TRACERS IN ALZHEIMER's DISEASE: [11C]THK5351 VERSUS [11C]PBB3 PET IMAGING

Chiotis K; Stenkrona P; Almkvist O; Arakawa R; Takano A; Stepanov V; Varrone A; Higuchi M; Halldin C; Nordberg A
Article: NEUROIMAGE. 2017;152:330-339

Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D_2/3 receptors and sub-cortical volumes in the human basal ganglia: A PET study with ¹⁸F-MNI-659 and ¹¹C-raelopride with correction for partial volume effect

Fazio P; Schain M; Mrzljak L; Amini N; Nag S; Al-Tawil N; Fitzer-Attas CJ; Bronzova J; Landwehrmeyer B; Sampaio C; Halldin C; Varrone A
Article: NEUROPHARMACOLOGY. 2017;117:171-181

In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects

Delnomdedieu M; Forsberg A; Ogden A; Fazio P; Yu C-R; Stenkrona P; Duvvuri S; David W; Al-Tawil N; Vitolo OV; Amini N; Nag S; Halldin C; Varrone A
Article: JOURNAL OF NUCLEAR MEDICINE. 2017;58(4):617-622

Longitudinal Small-Animal PET Imaging of the zQ175 Mouse Model of Huntington Disease Shows In Vivo Changes of Molecular Targets in the Striatum and Cerebral Cortex

Haggkvist J; Toth M; Tari L; Varnas K; Svedberg M; Forsberg A; Nag S; Dominguez C; Munoz-Sanjuan I; Bard J; Wityak J; Varrone A; Halldin C; Mrzljak L
Article: ANNALS OF NEUROLOGY. 2017;81(4):572-582

The Immune Response of the Human Brain to Abdominal Surgery

Forsberg A; Cervenka S; Fagerlund MJ; Rasmussen LS; Zetterberg H; Harris HE; Stridh P; Christensson E; Granstrom A; Schening A; Dymmel K; Knave N; Terrando N; Maze M; Borg J; Varrone A; Halldin C; Blennow K; Farde L; Eriksson LI
Article: NEUROBIOLOGY OF AGING. 2017;52:228-242

Clinical validity of presynaptic dopaminergic imaging with ¹²³I- ioflupane and noradrenergic imaging with ¹²³I- MIBG in the differential diagnosis between Alzheimer's disease and dementia with Lewy bodies in the context of a structured 5-phase development framework

Sonni I; Ratib O; Boccardi M; Picco A; Herholz K; Nobili F; Varrone A
Article: NEUROBIOLOGY OF AGING. 2017;52:214-227

Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

Chiotis K; Saint-Aubert L; Boccardi M; Gietl A; Picco A; Varrone A; Garibotto V; Herholz K; Nobili F; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2017;52:183-195

Clinical validity of brain fluorodeoxyglucose positron emission tomography as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

Garibotto V; Herholz K; Boccardi M; Picco A; Varrone A; Nordberg A; Nobili F; Ratib O
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44(3):382-391

Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer's disease and elderly controls after oral administration of sembragiline

Sturm S; Forsberg A; Nave S; Stenkrona P; Seneca N; Varrone A; Comley RA; Fazio P; Jamois C; Nakao R; Ejduk Z; Al-Tawil N; Akenine U; Halldin C; Andreasen N; Ricci B
Article: AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;7(6):246-254

Simplified estimation of binding parameters based on image-derived reference tissue models for dopamine transporter bindings in non-human primates using [18F]FE-PE2I and PET.

Odano I; Varrone A; Hosoya T; Sakaguchi K; Gulyás B; Padmanabhan P; Ghosh KK; Yang C-T; Guenther I; Wang Z; Serrano R; Chimon NG; Halldin C
Article: NEURON. 2016;92(6):1220-1237

Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models

Beaumont V; Zhong S; Lin H; Xu W; Bradaia A; Steidl E; Gleyzes M; Wadel K; Buisson B; Padovan-Neto FE; Chakroborty S; Ward KM; Harms JF; Beltran J; Kwan M; Ghavami A; Haggkvist J; Toth M; Halldin C; Varrone A; Schaab C; Dybowski JN; Elschenbroich S; Lehtimaki K; Heikkinen T; Park L; Rosinski J; Mrzljak L; Lavery D; West AR; Schmidt CJ; Zaleska MM; Munoz-Sanjuan I
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43(12):2255-2262

Guidelines to PET measurements of the target occupancy in the brain for drug development

Takano A; Varrone A; Gulyas B; Salvadori P; Gee A; Windhorst A; Vercouillie J; Bormans G; Lammertsma AA; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2016;57(10):1529-1534

Optimal Acquisition Time Window and Simplified Quantification of Dopamine Transporter Availability Using ¹⁸F-FE-PE2I in Healthy Controls and Parkinson Disease Patients

Sonni I; Fazio P; Sehain M; Halldin C; Svenningsson P; Farde L; Varrone A
Article: PSYCHIATRY RESEARCH-NEUROIMAGING. 2016;253:36-42

Low serotonin_1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder

Tiger M; Farde L; Ruck C; Varrone A; Forsberg A; Lindefors N; Halldin C; Lundberg J
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43(7):1323-1336

Reduction in camera-specific variability in [¹²³I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

Buchert R; Kluge A; Tossici-Bolt L; Dickson J; Bronzel M; Lange C; Asenbaum S; Booij J; Kapucu LOA; Svarer C; Koulibaly P-M; Nobili F; Pagani M; Sabri O; Sera T; Tatsch K; Vander Borght T; Van Laere K; Varrone A; Iida H
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43(7):1315-1322

Implementation of the European multicentre database of healthy controls for [¹²³I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes

Albert NL; Unterrainer M; Diemling M; Xiong G; Bartenstein P; Koch W; Varrone A; Dickson JC; Tossici-Bolt L; Sera T; Asenbaum S; Booij J; Kapucu LOA; Kluge A; Ziebell M; Darcourt J; Nobili F; Pagani M; Sabri O; Hesse S; Vander Borght T; Van Laere K; Tatsch K; la Fougere C
Article: NEUROIMAGE. 2016;133:313-320

Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data

Fazio P; Schain M; Varnas K; Halldin C; Farde L; Varrone A
Article: BRAIN BEHAVIOR AND IMMUNITY. 2016;54:149-157

In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects

Kanegawa N; Collste K; Forsberg A; Schain M; Arakawa R; Jucaite A; Lekander M; Hoglund CO; Kosek E; Lampa J; Halldin C; Farde L; Varrone A; Cervenka S
Article: JOURNAL OF NUCLEAR MEDICINE. 2016;57(2):315-320

In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, ¹⁸F-Labeled Deuterated Fluorodeprenyl

Nag S; Fazio P; Lehmann L; Kettschau G; Heinrich T; Thiele A; Svedberg M; Amini N; Leesch S; Catafau AM; Hannestad J; Varrone A; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43(1):173-183

Test-retest reproducibility of [¹¹C]PBR28 binding to TSPO in healthy control subjects

Collste K; Forsberg A; Varrone A; Amini N; Aeinehband S; Yakushev I; Halldin C; Farde L; Cervenka S
Journal article: CLINICAL AND TRANSLATIONAL IMAGING. 2015;3(6):389-390

Imaging of neuroinflammation: TSPO and beyond

Varrone A; Lammertsma AA
Journal article: CLINICAL AND TRANSLATIONAL IMAGING. 2015;3(6):437-447

Molecular imaging of neuroinflammation in Alzheimer’s disease

Varrone A; Nordberg A
Article: BRAIN. 2015;138(Pt 9):2687-2700

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease

Jucaite A; Svenningsson P; Rinne JO; Cselenyi Z; Varnas K; Johnstrom P; Amini N; Kirjavainen A; Helin S; Minkwitz M; Kugler AR; Posener JA; Budd S; Halldin C; Varrone A; Farde L
Article: SYNAPSE. 2015;69(7):365-374

5-HT_1B receptor imaging and cognition: A positron emission tomography study in control subjects and parkinson's disease patients

Varrone A; Svenningsson P; Marklund P; Fatouros-Bergman H; Forsberg A; Halldin C; Nilsson L-G; Farde L
Article: NEUROIMAGE. 2015;112:225-231

Diurnal and seasonal variation of the brain serotonin system in healthy male subjects

Matheson GJ; Schain M; Almeida R; Lundberg J; Cselenyi Z; Borg J; Varrone A; Farde L; Cervenka S
Article: JOURNAL OF NUCLEAR MEDICINE. 2015;56(5):714-720

Quantitative Analysis of ¹⁸F-(E)-N-(3-Iodoprop-2-Enyl)-2β-Carbofluoroethoxy-3β-(4′-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease

Fazio P; Svenningsson P; Forsberg A; Jonsson EG; Amini N; Nakao R; Nag S; Halldin C; Farde L; Varrone A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(3):1339-1346

Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients

Paul G; Zachrisson O; Varrone A; Almqvist P; Jerling M; Lind G; Rehncrona S; Linderoth B; Bjartmarz H; Shafer LL; Coffey R; Svensson M; Mercer KJ; Forsberg A; Halldin C; Svenningsson P; Widner H; Frisen J; Palhagen S; Haegerstrand A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42(3):438-446

Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [¹⁸F]FEMPA in Alzheimer's disease patients and control subjects

Varrone A; Oikonen V; Forsberg A; Joutsa J; Takano A; Solin O; Haaparanta-Solin M; Nag S; Nakao R; Al-Tawil N; Wells LA; Rabiner EA; Valencia R; Schultze-Mosgau M; Thiele A; Vollmer S; Dyrks T; Lehmann L; Heinrich T; Hoffmann A; Nordberg A; Halldin C; Rinne JO
Article: PLOS ONE. 2015;10(5):e0125917

Positron Emission Tomography studies with [¹¹C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation

Toth M; Doorduin J; Haggkvist J; Varrone A; Amini N; Halldin C; Gulyas B
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu081

Amphetamine Decreases α_2C-Adrenoceptor Binding of [¹¹C]ORM-13070: A PET Study in the Primate Brain

Finnema SJ; Hughes ZA; Haaparanta-Solin M; Stepanov V; Nakao R; Vamas K; Varrone A; Arponen E; Marjamaki P; Pohjanoksa K; Vuorilehto L; Babalola PA; Solin O; Grimwood S; Sallinen J; Farde L; Scheinin M; Halldin C
Article: EJNMMI RESEARCH. 2014;4(1):64

ABC transporter-dependent brain uptake of the 5-HT_1B receptor radioligand [¹¹C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig

Toth M; Haggkvist J; Varrone A; Finnema SJ; Doorduin J; Tokunaga M; Higuchi M; Gulyas B; Halldin C
Article: NEUROIMAGE. 2014;103:303-308

Distinct regional age effects on [¹¹C]AZ10419369 binding to 5-HT_1B receptors in the human brain

Nord M; Cselenyi Z; Forsberg A; Rosenqvist G; Tiger M; Lundberg J; Varrone A; Farde L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2014;41(10):1938-1946

Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

Koch W; Unterrainer M; Xiong G; Bartenstein P; Diemling M; Varrone A; Dickson JC; Tossici-Bolt L; Sera T; Asenbaum S; Booij J; Kapucu OL; Kluge A; Ziebell M; Darcourt J; Nobili F; Pagani M; Hesse S; Borght TV; Van Laere K; Tatsch K; la Fougere C
Article: NEUROINFORMATICS. 2014;12(4):551-562

Evaluation of Two Automated Methods for PET Region of Interest Analysis

Schain M; Varnas K; Cselenyi Z; Halldin C; Farde L; Varrone A
Article: PSYCHIATRY RESEARCH. 2014;223(2):164-170

Reduced 5-HT_1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder

Tiger M; Ruck C; Forsberg A; Varrone A; Lindefors N; Halldin C; Farde L; Lundberg J
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24(8):1240-1247

Association of central serotonin transporter availability and body mass index in healthy Europeans

Hesse S; van de Giessen E; Zientek F; Petroff D; Winter K; Dickson JC; Tossici-Bolt L; Sera T; Asenbaum S; Darcourt J; Akdemir UO; Knudsen GM; Nobili F; Pagani M; Vander Borght T; Van Laere K; Varrone A; Tatsch K; Sabri O; Booij J
Journal article: MOVEMENT DISORDERS. 2014;29(6):780-786

Supratentorial and Infratentorial Damage in Spinocerebellar Ataxia 2: A Diffusion-Weighted MRI Study

Salvatore E; Tedeschi E; Mollica C; Vicidomini C; Varrone A; Coda ARD; Brunetti A; Salvatore M; De Michele G; Filla A; Pappata S
Article: NEUROBIOLOGY OF AGING. 2014;35(4):867-875

Positron emission tomography imaging of 5-hydroxytryptamine_1B receptors in Parkinson's disease

Varrone A; Svenningsson P; Forsberg A; Varnas K; Tiger M; Nakao R; Halldin C; Nilsson L-G; Farde L
Article: NUCLEAR MEDICINE COMMUNICATIONS. 2014;35(3):231-237

Reproducibility of PET measurement for presynaptic dopaminergic functions using L-[β-¹¹C]DOPA and [¹⁸F]FE-PE2I in humans

Suzuki M; Ito H; Kodaka F; Takano H; Kimura Y; Fujiwara H; Sasaki T; Takahata K; Nogami T; Nagashima T; Nengaki N; Kawamura K; Zhang M-R; Varrone A; Halldin C; Okubo Y; Suhara T
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2013;21(21):6634-6641

Development of a novel fluorine-18 labeled deuterated fluororasagiline ([¹⁸F]fluororasagiline-D₂) radioligand for PET studies of monoamino oxidase B (MAO-B)

Nag S; Lehmann L; Kettschau G; Toth M; Heinrich T; Thiele A; Varrone A; Halldin C
Journal article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2013;333:e137

Safety and efficacy of recombinant human platelet derived growth factor (Rhpdgf) in Parkinson's disease

Paul G; Zachrisson O; Varrone A; Almqvist P; Jerling M; Lindh G; Rehncrona S; Linderoth B; Bjartmarz H; Svensson M; Mercer KJ; Forsberg A; Shafer LL; Lang AMJ; Halldin C; Svenningsson P; Widner H; Frisen J; Pålhagen S; Haegerstrand A
Article: JOURNAL OF NUCLEAR MEDICINE. 2013;54(10):1825-1832

Performance Evaluation of the Small-Animal nanoScan PET/MRI System

Nagy K; Toth M; Major P; Patay G; Egri G; Haggkvist J; Varrone A; Farde L; Halldin C; Gulyas B
Journal article: BRAIN BEHAVIOR AND IMMUNITY. 2013;32:e42

145. Translocator protein (TSPO) as a biomarker of microglia activation: PET imaging using [11C]PBR28 in Parkinson’s disease

Jucaite A; Cselényi Z; Varrone A; Varnäs K; Johnström P; Halldin C; Salter H; McLoughlin MJ; Rinne J; Svenningsson P; Alexander R; Kugler A; Farde L
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2013;33(7):1058-1065

Arterial input function derived from pairwise correlations between PET-image voxels

Schain M; Benjaminsson S; Varnas K; Forsberg A; Halldin C; Lansner A; Farde L; Varrone A
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(6):921-931

In vivo imaging of the ¹⁸-kDa translocator protein (TSPO) with [¹⁸F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients

Varrone A; Mattsson P; Forsberg A; Takano A; Nag S; Gulyas B; Borg J; Boellaard R; Al-Tawil N; Eriksdotter M; Zimmermann T; Schultze-Mosgau M; Thiele A; Hoffmann A; Lammertsma AA; Halldin C
Article: EJNMMI RESEARCH. 2013;3(1):39

No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [¹²³I]FP-CIT (DaTSCAN) and SPECT

Thomsen G; Knudsen GM; Jensen PS; Ziebell M; Holst KK; Asenbaum S; Booij J; Darcourt J; Dickson JC; Kapucu OL; Nobili F; Sabri O; Sera T; Tatsch K; Tossici-Bolt L; Van Laere K; Borght TV; Varrone A; Pagani M; Pinborg LH
Article: SYNAPSE. 2013;67(5):258-264

Brain uptake and distribution of the dopamine D3/D2 receptor partial agonist [11C]cariprazine: An in vivo positron emission tomography study in nonhuman primates

Toth M; Varrone A; Steiger C; Laszlovszky I; Horvath A; Kiss B; Gyertyan I; Adham N; Halldin C; Gulyas B
Article: EJNMMI RESEARCH. 2013;3(1):30

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [¹⁸F]FEDAA1106

Takano A; Piehl F; Hillert J; Varrone A; Nag S; Gulyas B; Stenkrona P; Villemagne VL; Rowe CC; Macdonell R; Al Tawil N; Kucinski T; Zimmermann T; Schultze-Mosgau M; Thiele A; Hoffmann A; Halldin C
Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):640-641

Erratum to: Automatic semi-quantification of [123I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database

Nobili F; Naseri M; De Carli F; Asenbaum S; Booij J; Darcourt J; Ell P; Kapucu Ö; Kemp P; Svarer C; Morbelli S; Pagani M; Sabri O; Tatsch K; Tossici-Bolt L; Sera T; Borght TV; Van Laere K; Varrone A
Article: NEUROIMAGE. 2013;69:78-86

Graphic plot analysis for estimating binding potential of translocator protein (TSPO) in positron emission tomography studies with [¹⁸F]FEDAA1106

Ikoma Y; Takano A; Varrone A; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(4):565-573

Automatic semi-quantification of [¹²³I]FP-CIT SPECT scans in healthy volunteers using BasGan version 2: results from the ENC-DAT database

Nobili F; Naseri M; De Carli F; Asenbaum S; Booij J; Darcourt J; Ell P; Kapucu O; Kemp P; Varer C; Morbelli S; Pagani M; Sabri O; Tatsch K; Tossici-Bolt L; Sera T; Vander Borght T; Van Laere K; Varrone A
Article: PLOS ONE. 2013;8(7):e69190

Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis

McNeill A; Wu R-M; Tzen K-Y; Aguiar PC; Arbelo JM; Barone P; Bhatia K; Barsottini O; Bonifati V; Bostantjopoulou S; Bressan R; Cossu G; Cortelli P; Felicio A; Ferraz HB; Herrera J; Houlden H; Hoexter M; Isla C; Lees A; Lorenzo-Betancor O; Mencacci NE; Pastor P; Pappata S; Pellecchia MT; Silveria-Moriyama L; Varrone A; Foltynie T; Schapira AHV
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2013;21(1):186-195

Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity

Nag S; Kettschau G; Heinrich T; Varrone A; Lehmann L; Gulyas B; Thiele A; Keller E; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(2):213-227

European multicentre database of healthy controls for [¹²³I]FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis

Varrone A; Dickson JC; Tossici-Bolt L; Sera T; Asenbaum S; Booij J; Kapucu OL; Kluge A; Knudsen GM; Koulibaly PM; Nobili F; Pagani M; Sabri O; Vander Borght T; Van Laere K; Tatsch K
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40(2):228-237

Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT

Schain M; Toth M; Cselenyi Z; Arakawa R; Halldin C; Farde L; Varrone A
Article: NEUROIMAGE. 2013;64:61-67

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

van de Giessen E; Hesse S; Caan MWA; Zientek F; Dickson JC; Tossici-Bolt L; Sera T; Asenbaum S; Guignard R; Akdemir UO; Knudsen GM; Nobili F; Pagani M; Borght TV; Van Laere K; Varrone A; Tatsch K; Booij J; Sabri O
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(11):1794-1801

Preclinical Characterization of a Novel Class of ¹⁸F-Labeled PET Tracers for Amyloid-β

Brockschnieder D; Schmitt-Willich H; Heinrich T; Varrone A; Gulyas B; Toth M; Andersson J; Boemer U; Krause S; Friebe M; Dinkelborg L; Halldin C; Dyrks T
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(7):1065-1073

Quantification of Dopamine Transporter in Human Brain Using PET with ¹⁸F-FE-PE2I

Sasaki T; Ito H; Kimura Y; Arakawa R; Takano H; Seki C; Kodaka F; Fujie S; Takahata K; Nogami T; Suzuki M; Fujiwara H; Takahashi H; Nakao R; Fukumura T; Varrone A; Halldin C; Nishikawa T; Suhara T
Article: BRAIN RESEARCH. 2012;1453:56-63

Signal transduction pathway activity compensates dopamine D₂/D₃ receptor density changes in Parkinson's disease: a preliminary comparative human brain receptor autoradiography study with [³H]raclopride and [³⁵S]GTPγS

Szabolcs F; Katalin N; Jia Z; Tibor H; Varrone A; Halldin C; Laszlo C; Gulyas B
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2012;20(9):3065-3071

Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)

Nag S; Lehmann L; Kettschau G; Heinrich T; Thiele A; Varrone A; Gulyas B; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32(4):685-695

Confirmation of fenfluramine effect on 5-HT_1B receptor binding of [¹¹C]AZ10419369 using an equilibrium approach

Finnema SJ; Varrone A; Hwang T-J; Halldin C; Farde L
Article: SYNAPSE. 2012;66(4):323-330

In vivo evaluation in cynomolgus monkey brain and metabolism of [18F]fluorodeprenyl: A new MAO-B pet radioligand

Nag S; Varrone A; Toth M; Thiele A; Kettschau G; Heinrich T; Lehmann L; Halldin C
Article: QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012

New developments of dopaminergic imaging in Parkinson's disease.

Varrone A; Halldin C
Article: QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012;56(1):68-82

New developments of dopaminergic imaging in Parkinson's disease

Varrone A; Halldin C
Article: NEUROIMAGE. 2012;60(1):800-807

Quantification of serotonin transporter availability with [¹¹C]MADAM - A comparison between the ECAT HRRT and HR systems

Schain M; Toth M; Cselenyi Z; Stenkrona P; Halldin C; Farde L; Varrone A
Article: NEUROIMAGE. 2012;59(4):3582-3593

Quantitative PET analyses of regional [¹¹C]PE2I binding to the dopamine transporter - Application to juvenile myoclonic epilepsy

Odano I; Varrone A; Savic I; Ciumas C; Karlsson P; Jucaite A; Halldin C; Farde L
Article: NUCLEAR MEDICINE AND BIOLOGY. 2012;39(2):295-303

Simplified quantification and whole-body distribution of [¹⁸F]FE-PE2I in nonhuman primates: prediction for human studies

Varrone A; Gulyas B; Takano A; Stabin MG; Jonsson C; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38(11):2058-2065

Biodistribution and radiation dosimetry of the 18 kDa translocator protein (TSPO) radioligand [¹⁸F]FEDAA1106: a human whole-body PET study

Takano A; Gulyas B; Varrone A; Karlsson P; Sjoholm N; Larsson S; Jonsson C; Odh R; Sparks R; Al Tawil N; Hoffmann A; Zimmermann T; Thiele A; Halldin C
Article: HUMAN BRAIN MAPPING. 2011;32(10):1626-1636

Extrastriatal Dopamine D₂ Receptor Binding in Huntington's Disease

Esmaeilzadeh M; Farde L; Karlsson P; Varrone A; Halldin C; Waters S; Tedroff J
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(8):1313-1321

Imaging of the Striatal and Extrastriatal Dopamine Transporter with ¹⁸F-LBT-999: Quantification, Biodistribution, and Radiation Dosimetry in Nonhuman Primates

Varrone A; Stepanov V; Nakao R; Toth M; Gulyas B; Emond P; Deloye JB; Vercouillie J; Stabin MG; Jonsson C; Guilloteau D; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38(8):1529-1540

Calibration of gamma camera systems for a multicentre European ¹²³I-FP-CIT SPECT normal database

Tossici-Bolt L; Dickson JC; Sera T; de Nijs R; Bagnara MC; Jonsson C; Scheepers E; Zito F; Seese A; Koulibaly PM; Kapucu OL; Koole M; Raith M; George J; Lonsdale MN; Muenzing W; Tatsch K; Varrone A
Article: NEUROIMAGE. 2011;56(3):1111-1121

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [¹¹C]vinpocetine

Gulyas B; Vas A; Toth M; Takano A; Varrone A; Cselenyi Z; Schain M; Mattsson P; Halldin C
Article: JOURNAL OF NUCLEAR MEDICINE. 2011;52(1):132-139

Kinetic Analysis and Quantification of the Dopamine Transporter in the Nonhuman Primate Brain with ¹¹C-PE2I and ¹⁸F-FE-PE2I

Varrone A; Toth M; Steiger C; Takano A; Guilloteau D; Ichise M; Gulyas B; Halldin C
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2011;31(1):113-123

Quantitative analysis of [¹¹C]AZ10419369 binding to 5-HT_1B receptors in human brain

Varnas K; Nyberg S; Halldin C; Varrone A; Takano A; Karlsson P; Andersson J; McCarthy D; Smith M; Pierson ME; Soderstrom J; Farde L
Article: SYNAPSE. 2010;64(7):573-577

Fenfluramine-Induced Serotonin Release Decreases [¹¹C]AZ10419369 Binding to 5-HT_1B-Receptors in the Primate Brain

Finnema SJ; Varrone A; Hwang TJ; Gulyas B; Pierson ME; Halldin C; Farde L
Article: SYNAPSE. 2010;64(6):478-485

PET Studies of D2-Receptor Binding in Striatal and Extrastriatal Brain Regions: Biochemical Support In Vivo for Separate Dopaminergic Systems in Humans

Cervenka S; Varrone A; Fransen E; Halldin C; Farde L
Journal article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(6):1156-1163

SPECT imaging of GABA_A/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment

Pappata S; Varrone A; Vicidomini C; Milan G; De Falco C; Sansone V; Iavarone A; Comerci M; Lore E; Panico MR; Quarantelli M; Postiglione A; Salvatore M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(1):23-35

The impact of reconstruction method on the quantification of DaTSCAN images

Dickson JC; Tossici-Bolt L; Sera T; Erlandsson K; Varrone A; Tatsch K; Hutton BF
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(12):2103-2110

EANM procedure guidelines for PET brain imaging using [¹⁸F]FDG, version 2

Varrone A; Asenbaum S; Vander Borght T; Booij J; Nobili F; Nagren K; Darcourt J; Kapucu OL; Tatsch K; Bartenstein P; Van Laere K
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(12):2093-2102

EANM procedure guideline for brain perfusion SPECT using ^99mTc-labelled radiopharmaceuticals, version 2

Kapucu OL; Nobili F; Varrone A; Booij J; Vander Borght T; Nagren K; Darcourt J; Tatsch K; Van Laere KJ
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(11):1885-1891

Comparative evaluations of norepinephrine transporter radioligands with reference tissue models in rhesus monkeys: (S,S)-[¹⁸F]FMeNER-D₂ and (S,S)-[¹¹C]MeNER

Takano A; Gulyas B; Varrone A; Halldin C
Article: SYNAPSE. 2009;63(10):871-880

In Vitro Autoradiography and In Vivo Evaluation in Cynomolgus Monkey of [¹⁸F]FE-PE2I, a New Dopamine Transporter PET Radioligand

Varrone A; Steiger C; Schou M; Takano A; Finnema SJ; Guilloteau D; Gulyas B; Halldin C
Article: BEHAVIORAL AND BRAIN FUNCTIONS. 2009;5:37

Differences at brain SPECT between depressed females with and without adult ADHD and healthy controls: etiological considerations

Gardner A; Salmaso D; Varrone A; Sanchez-Crespo A; Bejerot S; Jacobsson H; Larsson SA; Pagani M
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2009;19(16):4843-4845

Synthesis, radiolabeling and preliminary in vivo evaluation of [¹⁸F]FE-PE2I, a new probe for the dopamine transporter

Schou M; Steiger C; Varrone A; Guilloteau D; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(8):1308-1314

Saturated norepinephrine transporter occupancy by atomoxetine relevant to clinical doses: a rhesus monkey study with (S,S)-[¹⁸F]FMeNER-D₂

Takano A; Gulyas B; Varrone A; Maguire RP; Halldin C
Journal article: NEUROIMAGE. 2009;47:s77

Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

McNab F; Varrone A; Farde L; Jucaite A; Bystritsky P; Forssberg H; Klingberg T
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_12):p366

P3‐081: Reduction of cortical acetylcholine esterase in mild cognitive impairment: Consistency across centers and PET methods

Herholz K; Hohmann C; Florea I; Varrone A; Haense C; Krais R; Garibotto V; Kalbe E; Bertoldo A; Perani D; Vollmar S; Heiss W
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_1):p22

IC‐P‐043: Reduction of cortical acetylcholine esterase in mild cognitive impairment: Consistency across centers and PET methods

Herholz K; Hohmann C; Florea I; Varrone A; Haense C; Krais R; Garibotto V; Kalbe E; Bertoldo A; Perani D; Vollmar S; Heiss W
Article: NEUROIMAGE. 2009;45(3):891-902

[¹⁸F]Flumazenil binding to central benzodiazepine receptor studies by PET - Quantitative analysis and comparisons with [¹¹C]flumazenil

Odano I; Halldin C; Karlsson P; Varrone A; Airaksinen AJ; Krasikova RN; Farde L
Journal article: MOVEMENT DISORDERS. 2009;24(5):689-696

Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes

Pellecchia MT; Barone P; Mollica C; Salvatore E; Ianniciello M; Longo K; Varrone A; Vicidomini C; Picillo M; De Michele G; Filla A; Salvatore M; Pappata S
Article: SCIENCE. 2009;323(5915):800-802

Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

McNab F; Varrone A; Farde L; Jucaite A; Bystritsky P; Forssberg H; Klingberg T
Journal article: MOVEMENT DISORDERS. 2009;24(2):303-305

Cerebellar and Pyramidal Dysfunctions, Palpebral Ptosis and Weakness As Presenting Symptoms of PARK-2

Amboni M; Pellecchia MT; Cozzolino A; Pieillo M; Vitale C; Barone P; Varrone A; Garavaglia B; Gambelli S; Federico A
Article: NEUROIMAGE. 2008;42(2):474-482

Mapping of the norepinephrine transporter in the human brain using PET with (S,S)-[¹⁸F]FMeNER-D₂

Takano A; Varrone A; Gulyas B; Karlsson P; Tauscher J; Halldin C
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(7):1343-1349

Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [¹²³I]FP-CIT

Varrone A; Sansone V; Pellecchia MT; Amboni M; Salvatore E; De Michele G; Filla A; Barone P; Pappata S; Salvatore M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(3):630-636

Biodistribution and radiation dosimetry of the norepinephrine transporter radioligand (S,S)-[¹⁸F]FMeNER-D₂:: a human whole-body PET study

Takano A; Halldin C; Varrone A; Karlsson P; Sjoeholm N; Stubbs JB; Schou M; Airaksinen AJ; Tauscher J; Gulyas B
Article: NEUROIMAGE. 2008;39(3):1408-1419

Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET

Jovanovic H; Lundberg J; Karlsson P; Cerin A; Saijo T; Varrone A; Halldin C; Nordstrom A-L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35(1):153-157

Imaging the norepinephrine transporter with positron emission tomography:: initial human studies with (S,S)-[¹⁸F]FMeNER-D₂

Takano A; Gulyas B; Varrone A; Karlsson P; Schou M; Airaksinen AJ; Vandenhende F; Tauscher J; Halldin C
Journal article: JOURNAL OF NEUROLOGY. 2008;255(1):45-48

Nigrostriatal involvement in ataxia with oculomotor apraxia type 1

Salvatore E; Varrone A; Criscuolo C; Mancini P; Sansone V; Strisciuglio C; Cicala D; Scarano V; Salvatore M; Pappata S; De Michele G; Filla A
Article: MOVEMENT DISORDERS. 2007;22(14):2117-2121

Neuroimaging follow-up in a case of Rasmussen's encephalitis with dyskinesias

de Leva MF; Varrone A; Filla A; Quarantelli M; Bilo L; Piscitelli V; Salvatore E; Ammendola S; Striano S; De Michele G; Bonavita V; Pappata S
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34(7):1071-1081

Identification by [⁹⁹Tc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease

Varrone A; Pagani M; Salvatore E; Salmaso D; Sansone V; Amboni M; Nobili F; De Michele G; Filla A; Barone P; Pappata S; Salvatore M
Article: MOVEMENT DISORDERS. 2007;22(4):559-563

Parkinsonism and essential tremor in a family with pseudodominant inheritance of PARK2:: An FP-CIT SPECT study

Pellecchia MT; Varrone A; Annesi G; Amboni M; Cicarelli G; Sansone V; Annesi F; Rocca FE; Vitale C; Pappata S; Quattrone A; Barone P
Article: EPILEPTIC DISORDERS. 2006;8(4):289-293

Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?

Del Giudce E; Bianchi MC; Tosetti M; Varrone A; Romano A; Crisanti AF; Titomanilo L; Imperati F
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33(11):1374-1380

EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues

Borght TV; Asenbaum S; Bartenstein P; Halldin C; Kapucu O; Van Laere K; Varrone A; Tatsch K
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2006;49(11):1007-1019

Synthesis and PET evaluation of (R)-[S-methyl-¹¹C]thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters

Schou M; Pike VW; Varrone A; Gulyas B; Farde L; Halldin C
Article: PSYCHOPHARMACOLOGY. 2006;188(1):119-127

Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion:: a PET study in nonhuman primate brain using (S,S)-[¹⁸F]FMeNER-D₂

Seneca N; Gulyas B; Varrone A; Schou M; Airaksinen A; Tauscher J; Vandenhende F; Kielbasa W; Farde L; Innis RB; Halldin C
Article: MOVEMENT DISORDERS. 2006;21(8):1265-1267

PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of Parkinsonism

Criscuolo C; Volpe G; De Rosa A; Varrone A; Marongiu R; Mancini P; Salvatore E; Dallapiccola B; Filla A; Valente EM; De Michele G
Article: MOVEMENT DISORDERS. 2006;21(6):872-875

Characterization of nigrostriatal dysfunction in spinocerebellar ataxia 17

Salvatore E; Varrone A; Sansone V; Nolano M; Bruni AC; De Rosa A; Santoro L; Pappata S; Filla A; De Michele G
Article: NEUROLOGY. 2004;63(11):2097-2103

Imaging of dopaminergic dysfunction with [¹²³I]FP-CIT SPECT in early-onset parkin disease

Varrone A; Pellecchia MT; Amboni M; Sansone V; Salvatore E; Ghezzi D; Garavaglia B; Brice A; Brunetti A; Bonavita V; De Michele G; Salvatore M; Pappatà S; Barone P
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2004;31(5):644-654

Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D₂ receptors using [¹²³I]epidepride SPET

Fujita M; Varrone A; Kim KM; Watabe H; Zoghbi SS; Seneca N; Tipre D; Seibyl JP; Innis RB; Iida H
Article: ANNALS OF NEUROLOGY. 2004;55(3):426-430

Reduced striatal [¹²³I]FP-CIT binding in SCA2 patients without Parkinsonism

Varrone A; Salvatore E; De Michele G; Barone P; Sansone V; Pellecchia MT; Castaldo I; Coppola G; Brunetti A; Salvatore M; Pappatà S; Filla A
Article: JOURNAL OF NUCLEAR MEDICINE. 2003;44(4):512-519

Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities

Kim KM; Varrone A; Watabe H; Shidahara M; Fujita M; Innis RB; Iida H
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2002;29(11):1447-1454

Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks

Varrone A; Pappatà S; Caracò C; Soricelli A; Milan G; Quarantelli M; Alfano B; Postiglione A; Salvatore M
Article: MOVEMENT DISORDERS. 2001;16(6):1023-1032

[¹²³I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy

Varrone A; Marek KL; Jennings D; Innis RB; Seibyl JP
Article: JOURNAL OF NUCLEAR MEDICINE. 2000;41(8):1343-1351

Test-retest reproducibility of extrastriatal dopamine D₂ receptor imaging with [¹²³I]epidepride SPECT in humans

Varrone A; Fujita M; Verhoeff NPLG; Zoghbi SS; Baldwin RM; Rajeevan N; Charney DS; Seibyl JP; Innis RB
Journal article: EJSO. 2000;26(4):381-386

Significance of duplex/colour Doppler sonography in hepatic arterial chemotherapy for patients with liver metastases from colorectal carcinoma

Guadagni S; Pizzutilli A; Mancini E; Varrone A; Palumbo G; Amicucci G; Perri S; Deraco M; Fiorentini G
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2000;387(2):179-188

Imaging extrastriatal dopamine D₂ receptor occupancy by endogenous dopamine in healthy humans

Fujita M; Verhoeff NPLG; Varrone A; Zoghbi SS; Baldwin RM; Jatlow PA; Anderson GM; Seibyl JP; Innis RB
Article: CLINICAL NUCLEAR MEDICINE. 1999;24(9):660-665

Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT

Varrone A; Soricelli A; Postiglione A; Salvatore M
Article: JOURNAL OF NUCLEAR CARDIOLOGY. 1999;6(3):270-277

Excercise-rest Tc-99m tetrofosmin SPECT in patients with chronic ischemic left ventricular dysfunction: Direct comparison with Tl-201 reinjection

Nicolai E; Cuocolo A; Acampa W; Varrone A; Pace L; Salvatore M
Article: JOURNAL OF NUCLEAR MEDICINE. 1998;39(11):1869-1874

Identification of viable myocardium in patients with chronic coronary artery disease using rest-redistribution thallium-201 tomography: Optimal image analysis

Pace L; Perrone-Filardi P; Mainenti P; Cuocolo A; Vezzuto P; Prastaro M; Varrone A; De Luca G; Soricelli A; Betocchi S; Chiariello M; Salvatore M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1998;25(7):744-750

Combined evaluation of rest-redistribution thallium-201 tomography and low-dose dobutamine echocardiography enhances the identification of viable myocardium in patients with chronic coronary artery disease

Pace L; Perrone-Filardi P; Mainenti P; Prastaro M; Vezzuto P; Varrone A; Crisci T; Cuocolo A; Dellegrottaglie S; Piscione F; Chiariello M; Salvatore M
Article: JOURNAL OF NUCLEAR CARDIOLOGY. 1998;5(3):265-274

Direct comparison of technetium 99m sestamibi and technetium 99m tetrofosmin cardiac single photon emission computed tomography in patients with coronary artery disease

Acampa W; Cuocolo A; Sullo P; Varrone A; Nicolai E; Pace L; Petretta M; Salvatore M
Article: JOURNAL OF NUCLEAR MEDICINE. 1998;39(5):802-806

Technetium-99m-tetrofosmin uptake in brain tumors by SPECT: Comparison with thallium-201 imaging

Soricelli A; Cuocolo A; Varrone A; Discepolo A; Tedeschi E; Mainenti PP; Grivet-Fojaja MR; Covelli EM; Postiglione A; Salvatore M
Article: JOURNAL OF NUCLEAR CARDIOLOGY. 1998;5(2):153-160

Effects of myocardial revascularization on regional thallium-201 uptake and systolic function in regions with reverse redistribution on tomographic thallium-201 imaging at rest in patients with chronic coronary artery disease

Pace L; Perrone-Filardi P; Mainenti PP; Prastaro M; Cuocolo A; Varrone A; Vezzuto P; Crisci T; Soricelli A; Piscione F; Chiariello M; Salvatore M
Article: JOURNAL OF NUCLEAR MEDICINE. 1997;38(6):948-953

Ambulatory monitoring of left ventricular function: Walk and bicycle exercise in congestive heart failure

Nappi A; Cuocolo A; Imbriaco M; Nicolai E; Varrone A; Morisco C; Romano M; Trimarco B; Salvatore M
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1996;23(10):1323-1328

Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses

Soricelli A; Postiglione A; GrivetFojaja MR; Mainenti PP; Discepolo A; Varrone A; Salvatore M; Lassen NA
Article: MOLECULAR CANCER RESEARCH. 1995;6(1):91-95

KI-RAS ONCOGENE INTERFERES WITH THE EXPRESSION OF CYCLIC-AMP-DEPENDENT PROMOTERS

GALLO A; FELICIELLO A; VARRONE A; CERILLO R; GOTTESMAN ME; AVVEDIMENTO VE
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Preprint: MEDRXIV. 2023

Spinocerebellar ataxia type 4 is caused by a GGC expansion in theZFHX3gene and is associated with prominent dysautonomia and motor neuron signs

Paucar M; Nilsson D; Engvall M; Laffita-Mesa J; Söderhäll C; Skorpil M; Halldin C; Fazio P; Lagerstedt-Robinson K; Solders G; Angeria M; Varrone A; Risling M; Jiao H; Nennesmo I; Wedell A; Svenningsson P
Conference publication: MOVEMENT DISORDERS. 2023;38:S5-S6

Baseline Characteristics for Patients with Multiple System Atrophy Entering a Randomized, Controlled Study of the Anti-a-synuclein Monoclonal Antibody Lu AF82422

Singer W; Takeda A; Kjaersgaard L; Wiedemann J; Berger A; Varrone A; Bidani A; Meulien D
Corrigendum: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;49(6):2100-2101

EANM procedure guidelines for brain PET imaging using [¹⁸F]FDG, version 3 (vol 49, pg 632, 2022)

Guedj E; Varrone A; Boellaard R; Albert NL; Barthel H; van Berckel B; Brendel M; Cecchin D; Ekmekcioglu O; Garibotto V; Lammertsma AA; Law I; Penuelas I; Semah F; Traub-Weidinger T; van de Giessen E; Van Weehaeghe D; Morbelli S
Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2022;108:S26

Synthesis and biological evaluation of a novel radioligand [¹¹C]BIO-1790735 for detection of O-GlcNAcase (OGA) enzyme activity

Nag S; Arakawa R; Datta P; Moren A; Varrone A; Moein MM; Bolin M; Lin E; Genung N; Martarello L; Kaliszczak M; Halldin C
Book chapter: NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;p. 83-98

New PET radiopharmaceuticals for imaging CNS diseases

Brumberg J; Varrone A
Conference publication: MOVEMENT DISORDERS. 2022;37:S482

Tracking longitudinal changes in MSA: TALISMAN study protocol

Meissner W; Varrone A; Sahib A; Astrom D; Clarimon J; Andreasen A; Berger AK; Wiedemann J; Sgarbi S; Meulien D
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):205-206

Non-displacable binding is a potential confounding factor in [¹¹C]PBR28 PET studies

Laurell GL; Plaven-Sigray P; Jucaite A; Varrone A; Cosgrove KP; Svarer C; Knudsen GM; Ogden RT; Zanderigo F; Cervenka S; Hillmer AT; Schain M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021;48(SUPPL 1):S208-S209

Imaging With [¹⁸F]FE-PE2I Suggests a Non-Linear Relationship Between Dopamine Transporter Availability and Motor Symptom Severity in Patients With Non-Advanced Parkinson′s Disease

Kerstens V; Fazio P; Sundgren M; Halldin C; Svenningsson P; Varrone A
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2021;16(3):S620

A PET and MRI Study Exploring Osimertinib Brain Exposure and Efficacy in EGFRm NSCLC CNS Metastases

Ekman S; Cselenyi Z; Varrone A; Jucaite A; Martin H; Schou M; Johnstrom P; Laus G; Lewensohn R; Brown A; Van der Aart J; Vishwanathan K; Farde L
Preprint: SSRN ELECTRONIC JOURNAL. 2021

Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Pet Study Using [ ¹¹C ] PBR28 and Machine Learning Enhanced Analysis

Jucaite A; Cselényi Z; Kreisl WC; Rabiner EA; Varrone A; Carson RE; Rinne JO; Savage A; Schou M; Johnström P; Svenningsson P; Rascol O; Meissner WG; Barone P; Seppi K; Kaufmann H; Wenning GK; Poewe W; Farde L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):105-106

Evaluation in rat, monkey, and humans of [¹⁸F]PF-06445974, a PET radioligand for phosphodiesterase 4B

Wakabayashi Y; Stenkrona P; Liow J-S; Maresca KP; Chappie TA; Zhang L; Hughes ZEA; Schmidt CJ; Doran SD; Arakawa R; Varrone A; Takano A; Fregonara PZ; Zoghbi SS; Ooms M; Morse C; Pike VW; Halldin C; Innis RB
Conference publication: MOVEMENT DISORDERS. 2021;36:S177

First-in-man clinical trial of intraputamenal CDNF in Parkinson's disease finds a consorted biomarker response in a subgroup of subjects

Huttunen H; Booms S; Sjogren M; Cryar A; Harris J; Sirka E; Dove M; Majbour N; Abdesselem H; El-Agnaf O; Koskinen J; Holmnas R; Kerstens V; Johansson J; Rinne J; Varrone A; Woolley M; Murphy B; Fielder P; Baker J; Skinner P; Andreasson M; Paul-Visse G; Kivisaari R; Bjartmarz H; Lind G; Almqvist P; Scheperjans F; Widner H; Svenningsson P
Corrigendum: MOVEMENT DISORDERS. 2020;35(12):2363-2364

PET Molecular Imaging of Phosphodiesterase 10A: An Early Biomarker of Huntington's Disease Progression (vol 35, pg 606, 2020)

Fazio P; Fitzer-Attas CJ; Mrzljak L; Bronzova J; Nag S; Warner JH; Landwehrmeyer B; Al-Tawil N; Halldin C; Forsberg A; Ware J; Dilda V; Wood A; Sampaio C; Varrone A
Review: CLINICAL AND TRANSLATIONAL IMAGING. 2020;8(5):349-356

Dopamine transporter imaging in neurodegenerative movement disorders: PET vs. SPECT

Kerstens VS; Varrone A
Editorial comment: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(11):2487-2492

COVID-19 and the brain: impact on nuclear medicine in neurology

Morbelli S; Ekmekcioglu O; Barthel H; Albert NL; Boellaard R; Cecchin D; Guedj E; Lammertsma AA; Law I; Penuelas I; Semah F; Traub-Weidinger T; van de Giessen E; Varrone A; Garibotto V
Editorial comment: BRAIN. 2020;143(9):2634-2636

Timing is everything: tau imaging across stages of Alzheimer's disease

Moren AF; Varrone A
Preprint: RESEARCH SQUARE. 2020

Reliability of Dopamine Transporter PET Measurements with [18F]FE-PE2I in patients with Parkinson´s Disease

Kerstens V; Fazio P; Sundgren M; Matheson G; Franzén E; Halldin C; Cervenka S; Svenningsson P; Varrone A
Preprint: RESEARCH SQUARE. 2020

Reliability of Dopamine Transporter PET Measurements with [18F]FE-PE2I in patients with Parkinson's Disease

Kerstens VS; Fazio P; Sundgren M; Matheson GJ; Franzén E; Halldin C; Cervenka S; Svenningsson P; Varrone A
Conference publication: MOVEMENT DISORDERS. 2020;35:S403

Phase I-II first-in-human clinical study of intraputamenal CDNF in Parkinson's disease: Exploratory PET imaging endpoints of the 12-month treatment period

Kerstens V; Fazio P; Johansson J; Granberg T; Booms S; Huttunen H; Sjogren M; Woolley M; Murphy B; Fielder P; Baker J; Skinner P; Andreasson M; Paul-Visse G; Kivisaari R; Bjartmarz H; Lind G; Almqvist P; Scheperjans F; Widner H; Svenningsson P; Rinne J; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(SUPPL 1):S493-S494

A Positron Emission Tomography (PET) Study to Examine the Brain Binding of[¹¹C]-PXT012253 in Healthy Subjects

Stenkrona P; Arakawa R; Holst H; Nag S; Moein MM; Jia Z; Halldin C; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(SUPPL 1):S117

Identification and in vitrocharacterization of C05-01, a PPB3 derivative with improved affinity for α-synuclein

Azpiazu PM; Svedberg M; Higuchi M; Ono M; Jia Z; Sunnemark D; Elmore C; Schou M; Varrone A
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2020;61

Early peak equilibrium is superior to late pseudo-equilibrium for simplified quantification of ¹⁸F-FE-PE2I PET

Brumberg J; Kerstens V; Cselenyi Z; Svenningsson P; Mathias S; Fazio P; Varrone A
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2020;63(7):358-359

Synthesis, ³H-labelling, and in vitro evaluation of a potential ligand for chemokine receptor 2

Artelsmair M; Azpiazu PM; Kingston L; Bergare J; Schou M; Varrone A; Elmore CS
Conference publication: MOVEMENT DISORDERS. 2020;35:S390

Phase I-II first-in-human clinical trial of intraputamenal CDNF in Parkinson's disease: Topline results of the six-month double-blind placebo-controlled main study and the six-month active treatment extension study

Booms S; Huttunen H; Koskinen J; Sjogren M; Saarma M; Woolley M; Murphy B; Fielder P; Baker J; Skinner P; Rinne J; Varrone A; Andreasson M; Paul-Visse G; Kivisaari R; Bjartmarz H; Lind G; Almqvist P; Scheperjans F; Widner H; Svenningsson P
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2019;14(10):S842

An Open-Label PET-MRI Study to Determine Brain Exposure of Osimertinib in Patients with EGFR Mutant NSCLC and CNS Metastases

Ekman S; Varrone A; Jucaite A; Vishwanathan K; Brown A; Cselenyi Z; Martin H; Lewensohn R; Schou M; Laus G; Van Der Aart J; Johnstrom P; Singh N; Farde L
Preprint: BIORXIV. 2019

Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [11C]PBR28 HRRT PET study

Tuisku J; Plavén-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Brück A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamäki P; Rissanen E; Sucksdorff M; Varrone A; Rinne J; Matuskey D; Cervenka S
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2019;39:544

Striatal dopamine transporter availability and D2 receptor density correlate to relative blood flow measured with [¹¹C]PE2I, [¹⁸F]FE-PE2I and [¹¹C]raclopride PET

Jonasson M; Fazio P; Frick A; Appel L; Laurell GL; Danfors T; Fredrikson M; Furmark T; Varrone A; Lubberink M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(SUPPL 1):S392-S393

Reliability of Dopamine Transporter PET Measurements with [¹⁸F]FE-PE2I in Early Stage Parkinson's Disease: A Preliminary Test-Retest Evaluation

Kerstens V; Fazio P; Sundgren M; Matheson GJ; Franzen E; Halldin C; Cervenka S; Svenningsson P; Varrone A
Book chapter: PET/CT IN BRAIN DISORDERS: CLINICIANS’ GUIDES TO RADIONUCLIDE HYBRID IMAGING. 2019;p. 49-64

[18F]FDG-PET/CT in Movement Disorders

Fazio P; Varrone A
Review: CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS. 2018;18(12):85

Novel Imaging Biomarkers for Huntington's Disease and Other Hereditary Choreas

Fazio P; Paucar M; Svenningsson P; Varrone A
Conference publication: CANCER RESEARCH. 2018;78(13):ct013

Osimertinib displays high brain exposure in healthy subjects with intact blood-brain barrier: a microdose positron emission tomography (PET) study with ¹¹C-labelled osimertinib

Vishwanathan K; Varrone A; Varnas K; Jucaite A; Cselenyi Z; Johnstrom P; Schou M; Vasquez-Romero A; Moein MM; Halldin C; Brown AP; Farde L
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S648-S649

Brain exposure of ATM inhibitor AZD1390: positron emission tomography (PET) study in healthy human subjects

Varnas K; Jucaite A; Stenkrona P; De Vita S; Savage A; Varrone A; Johnstrom P; Cselenyi Z; Schou M; Davison C; Sykes A; Hoch M; Vazquez-Romero A; Moein MM; Halldin C; Merchant MS; Pass M; Farde L
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S719-S720

Quantitative evaluation of the Mediso high resolution PET/CT system LFER150 using non-human primate brain imaging

Arakawa R; Toth M; Sarnyai Z; Nagy K; Rosenqvist G; Nemeth G; Halldin C; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S268-S269

Molecular Mapping of Serotoninergic and Dopaminergic Projections from Brainstem to Striatal Areas in Early Parkinson's disease Patients

Fazio P; Svenningsson P; Cselenyi Z; Halldin C; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S646-S647

Testing The Feasibility of a Dihidro Thiazolo Ring-fused 2-pyridone Derivative As a Possible PET Ligand to Target Alpha-synuclein in Neurogenerative Disorders

Azpiazu PM; Schou M; Eriksson A; Elmore C; Almqvist F; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S303-S304

Blood Flow Dependence of Early [¹¹C]PE2I and [¹⁸F]FE-PE2I PET SUVR Measurements Used In the Differential Diagnosis of Parkinsonian Disorders

Jonasson M; Langaas G; Appel L; Danfors T; Fazio P; Lubberink M; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S213

PET Imaging of Beta-secretase 1 in The Human Brain: Quantification and Test-Retest Examination with [¹⁸F]PF-06684511

Varrone A; Arakawa R; Takano A; Stenkrona P; Nag S; Stepanov V; Jahan M; Chen L; He P; Villalobos A; McCarthy T; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2018;45:S622

Whole blood sampling utilizing microextraction by packed sorbents (MEPS) technique for [¹¹C] SMW139 radiometabolite analysis in micro-PET

Moein M; Toth M; Tari L; Varrone A; Halldin C
Review: INTERNATIONAL REVIEW OF NEUROBIOLOGY. 2018;142:225-260

SPECT Molecular Imaging in Familial Parkinson's Disease

Varrone A; Pellecchia MT
Review: LANCET NEUROLOGY. 2017;16(8):661-676

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

Frisoni GB; Boccardi M; Barkhof F; Blennow K; Cappa S; Chiotis K; Demonet J-F; Garibotto V; Giannakopoulos P; Gietl A; Hansson O; Herholz K; Jack CRJ; Nobili F; Nordberg A; Snyder HM; Ten Kate M; Varrone A; Albanese E; Becker S; Bossuyt P; Carrillo MC; Cerami C; Dubois B; Gallo V; Giacobini E; Gold G; Hurst S; Loenneborg A; Lovblad K-O; Mattsson N; Molinuevo J-L; Monsch AU; Mosimann U; Padovani A; Picco A; Porteri C; Ratib O; Saint-Aubert L; Scerri C; Scheltens P; Schott JM; Sonni I; Teipel S; Vineis P; Visser PJ; Yasui Y; Winblad B
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44:S364-S365

Injected Mass is a Limiting Factor for Small Animal PET Studies Using High-Affinity Radioligands: Evidence from a Study Using [11C]- and [18F]Fallypride

Toth M; Nag S; Jia Z; Haggkvist J; Mukherjee J; Varrone A; Halldin C
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37:165-166

Assessment of the reliability and validity of simplified ratio-based quantification approaches for [¹¹C]PBR28

Matheson GJ; Sigray PP; Forsberg A; Collste K; Varrone A; Halldin C; Farde L; Cervenka S
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44:S432

Performance Evaluation of a New High Resolution Non-human Primate (NHP) PET/CT System (LFER 150 PET/CT)

Sarnyai Z; Nagy K; Patay G; Molnar M; Rosenqvist G; Toth M; Takano A; Gulyas B; Halldin C; Major P; Varrone A
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37:90-91

PET imaging of [¹¹C]PBR28 in patients with Parkinson's disease does not indicate increased binding to TSPO

Varnas K; Cselenyi Z; Jucaite A; Halldin C; Svenningsson P; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2017;44:S172

Human Whole-body Biodistribution and Radiation Dosimetry of [¹⁸F]PF-06684511, a Novel Radioligand for Brain Imaging of Beta-secretase

Varrone A; Arakawa R; Takano A; Nag S; Stepanov V; Stenkrona P; Gryback P; Bolin M; Chen L; Zhang L; He P; Villalobos A; McCarthy T; Halldin C
Conference publication: MOVEMENT DISORDERS. 2017;32

In vivo mapping of nigro-striatal dopamine transporter (DAT) availability in early Parkinson's disease patients using [18F]FE-PE2I and high-resolution positron emission tomography.

Fazio P; Svenningsson P; Cselenyi Z; Halldin C; Farde L; Varrone A
Conference publication: MOVEMENT DISORDERS. 2017;32

Imaging of phosphodiesterase 10 A (PDE10A) enzyme levels in the living human brain of Huntington's disease gene expansion carriers and healthy controls with positron emission tomography.

Fazio P; Fittzer-Attas C; Bronzova J; Nag S; Warner J; Landwehrmeyer B; Al-Tawil N; Halldin C; Mrzljak L; Sampaio C; Varrone A
Conference publication: BRAIN BEHAVIOR AND IMMUNITY. 2016;57:E38

Cross-sectional and longitudinal associations between immune cells in blood and brain - A TSPO PET study in healthy control subjects

Kanegawa N; Collste K; Forsberg A; Schain M; Arakawa R; Jucaite A; Lekander M; Hoglund CO; Kosek E; Lampa J; Halldin C; Farde L; Varrone A; Cervenka S
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:614-615

MAPPING MAO-B WITH FLUORINE-18 LABELED DEUTERATED FLUORODEPRENYL (18F-FLUORODEPRENYL-D2). DEVELOPMENT, IN VITRO AUTORADIOGRAPHY AND IN VIVO EVALUATION IN NON-HUMAN PRIMATES.

Nag S; Fazio P; Svedberg M; Amini N; Lehmann L; Kettschau G; Heinrich T; Leesch S; Catafau A; Varrone A; Halldin C
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:676

PET STUDY OF THALAMIC DOPAMINE D2-RECEPTORS IN DRUG-NAIVE PATIENTS WITH SCHIZOPHRENIA

Ikonen P; Cervenka S; Collste K; Fatouros-Bergman H; Matheson G; Sigray PP; Varrone A; Halldin C; Flyckt L; Farde L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:639-640

TOWARDS LESS-INVASIVE QUANTIFICATION OF [11C]PBR28: IMAGE-DERIVED AND POPULATION-BASED INPUT FUNCTIONS

Kanegawa N; Schain M; Collste K; Amini N; Takano A; Halldin C; Cervenka S; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43:S511

Initial Evaluation of a New High Resolution Non-human Primate (NHP) PET System (LFER 150)

Sarnyai Z; Nagy K; Rosenqvist G; Takano A; Maior R; Toth M; Gulyas B; Halldin C; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43:S615

Astrocyte Involvement in TSPO Signal After Microglia Depletion in mice

Toth M; Harald L; Haggkvist J; Forsberg A; Varrone A; Halldin C; Harris R; Farde L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:640-641

VALIDATION OF PARTIAL VOLUME EFFECT CORRECTION BASED ON FREESURFER AND AAL SEGMENTATION

Schain M; Cselenyi Z; Arakawa R; Rosenqvist G; Halldin C; Farde L; Varrone A
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:641-642

IMPROVED ACCURACY IN THE ESTIMATION OF THE DISTRIBUTION VOLUME OF [18F]MNI-659 IN CEREBELLUM

Schain M; Fazio P; Mrzljak L; Amini N; Al-Tawil N; Fitzer-Attas C; Bronzova J; Landwehrmeyer B; Sampaio C; Halldin C; Varrone A
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:396-397

MOLECULAR AND STRUCTURAL AGE-RELATED CHANGES IN THE BASAL GANGLIA. A HIGH RESOLUTION PET STUDY WITH 11C-RACLOPRIDE AND 18F-MNI-659.

Fazio P; Schain M; Mrzljak L; Amini N; Al-Tawil N; Fitzer-Attas C; Bronzova J; Landwehrmeyer B; Sampaio C; Halldin C; Varrone A
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:675-676

DIURNAL AND SEASONAL VARIATION OF THE BRAIN SEROTONIN SYSTEM IN HEALTHY MALE SUBJECTS

Matheson GJ; Schain M; Almeida R; Lundberg J; Cselenyi Z; Borg J; Varrone A; Farde L; Cervenka S
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2016;43:S533

Dosimetry and whole body distribution of [¹⁸F]PE2I in healthy volunteers

Lizana H; Johansson L; Larsson A; Axelsson J; Linder J; Ogren M; Varrone A; Halldin C; Mo SJ
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:655

LONGITUDINAL PET IMAGING OF ZQ175, A MOUSE MODEL OF HUNTINGTONS DISEASE

Haggkvist J; Toth M; Tari L; Varnas K; Dominguez C; Munoz-Sanjuan I; Varrone A; Halldin C; Mrzljak L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:734

LONGITUDINAL [11C]PBR28 IMAGING OF ACUTE NEUROINFLAMMATION IN A CLINICALLY RELEVANT ISCHEMIC STROKE RAT MODEL

Toth M; Little P; Arnberg F; Haggkvist J; Mulder J; Varrone A; Halldin C; Gulyas B; Holmin S
Book chapter: PET-CT AND PET-MRI IN NEUROLOGY. 2016;p. 103-125

Movement Disorders: Focus on Parkinson’s Disease and Related Disorders

Varrone A; Pappatà S; Quarantelli M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42:S578-S579

Distribution of the Dopamine Transporter (DAT) in the nigro-striatal pathway examined in vivo with [18F] FE-PE2I and high-resolution PET

Fazio P; Cselenyi Z; Halldin C; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42:S235-S236

Simplified quantification of the dopamine transporter using [18F]FE-PE2I in PD patients and control subjects

Sonni I; Fazio P; Schain M; Halldin C; Svenningsson P; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42:S235

Maps of serotonin transporter distribution in the human brainstem obtained using high-resolution PET correlates with post-mortem autoradiography data (ARG)

Fazio P; Schain M; Varnas K; Halldin C; Farde L; Varrone A
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2015;56(3)

Optimal acquisition time window for quantification of dopamine transporter availability with [¹⁸F]FE-PE2I in controls and PD patients

Sonni I; Fazio P; Schain M; Halldin C; Svenningsson P; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42:S558

Imaging Mutant Huntingtin Aggregates: Development of Potential PET Ligands

Brown CJ; Prime M; Clark-Frew D; Schaertl S; Haeggkvist J; Halldin C; Stepanov V; Varrone A; Varnaes K; Svedberg M; Munoz-Sanjuan I; Khetarpal V; Bard J; Wityak J; Dominguez C
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2015;58:S239

Using Biotransformations for Radioligand Discovery and Validation - Preparative Liver Microsome Incubations Shed Further Light on the Impact of Radiometabolites on In Vivo Imaging

Schou M; Amini N; Westermark A; Jacobson-Ingemyr H; Takano A; Svedberg M; Toth M; Tari L; Haggkvist J; Varrone A; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42:S22

Longitudinal Imaging of Acute Neuroinflammation with [11C]PBR28 in an Ischemic Stroke Rat Model

Toth M; Little P; Arnberg F; Haggkvist J; Mulder J; Varrone A; Halldin C; Gulyas B; Holmin S
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2015;40:S142-S143

Low Serotonin 1B Receptor Binding Potential in the Anterior Cingulate Cortex in Drug-Free Patients with Recurrent Major Depressive Disorder

Tiger M; Farde L; Ruck C; Varrone A; Forsberg A; Lindefors N; Halldin C; Lundberg J
Conference publication: MOVEMENT DISORDERS. 2015;30:S539

Dopamine D2 receptor and phosphodiesterase 10A loss in Huntingtons disease measured with high-resolution PET and partial volume effect correction

Fitzer-Attas C; Varrone A; Fazio P; Schain M; Mrzljak L; Bronzova J; Landwehrmeyer B; Al-Tawil N; Martinsson S; Halldin C; Sampaio C
Conference publication: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2014;85:A47

POSITRON EMISSION TOMOGRAPHY IMAGING OF PHOSPHODIESTERASE 10 A ENZYME AND DOPAMINE D2 RECEPTOR IN HUNTINGTON'S DISEASE GENE EXPANSION CARRIERS

Fazio P; Fitzer-Attas C; Mrzljak L; Martinsson S; Landwehrmeyer GB; Bronzova J; Al-Tawil N; Halldin C; Sampaio C; Varrone A
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2014;55

The automated receptor imaging system (ARIS) for quantitative image processing to estimate binding parameters for dopamine transporter [18F]FE-PE2I studies in non-human primate (NHP)

Odano I; Guenther I; Wang Z; Serrano R; Gsell W; Chang YQ; Nag S; Chimon G; Varrone A; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2014;55

The automated receptor imaging system (ARIS) for quantitative image processing to estimate binding parameters for dopamine transporter [18F]FE-PE2I studies in non-human primate (NHP)

Odano I; Guenther I; Wang Z; Serrano R; Gsell W; Chang YQ; Nag S; Chimon G; Varrone A; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2014;41:S275-S276

Quantification of Dopamine Transporter Availability in Striatum and Substantia Nigra of Parkinson's Disease Patients with [18F]FE-PE2I and High-Resolution PET

Fazio P; Svenningsson P; Forsberg A; Jonsson EG; Amini N; Nakao R; Halldin C; Farde L; Varrone A
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2014;55

Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: A template-based analysis

Fazio P; Schain M; Varnas K; Halldin C; Farde L; Varrone A
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2014;55

Quantitative analysis of [¹⁸F]FE-PE2I binding to the dopamine transporter in Parkinson's disease

Fazio P; Svenningsson P; Forsberg A; Jonsson E; Amini N; Nakao R; Halldin C; Farde L; Varrone A
Book chapter: IMAGING OF THE HUMAN BRAIN IN HEALTH AND DISEASE. 2014;p. 203-240

Chapter Nine Human Brain Imaging of Dopamine Transporters

Varrone A; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2014;41:S184-S185

In vivo microPET imaging of striatal and cortical molecular targets in the Q175 mouse model of Huntington's disease

Haggkvist J; Toth M; Tari L; Varnas K; Dominguez C; Munoz-Sanjuan I; Varrone A; Halldin C; Mrzljak L
Conference publication: MOVEMENT DISORDERS. 2014;29(14):1843

Imaging of phosphodiesterase 10A (PDE10A) enzyme and D2 receptor levels in the living brain of Huntington's disease gene expansion carriers and healthy controls

Fitzer-Attas C; Fazio P; Mrzljak L; Martinsson S; Landwehrmeyer B; Bronzova J; Al-Tawil N; Halldin C; Sampaio C; Varrone A
Conference publication: MOVEMENT DISORDERS. 2014;29:S246

Effect of the myeloperoxidase inhibitor AZD3241 on translocator protein binding in brain - A positron emission tomography study in patients with Parkinson's disease

Jucaite A; Svennigsson P; Rinne J; Cselenyi Z; Varrone A; Karlsson P; Varnas K; Johnstrom P; McLoughlin MJ; Halldin C; Posener J; Salter H; Kugler A; Budd S; Farde L
Conference publication: MOVEMENT DISORDERS. 2014;29:S207-S208

Imaging of phosphodiesterase 10A (PDE10A) enzyme and D₂ receptor levels in the living brain of Huntington's disease gene expansion carriers and healthy controls

Fitzer-Attas C; Fazio P; Mrzljak L; Martinsson S; Landwehr-Meyer B; Bronzova J; Al-Tawil N; Halldin C; Sampaio C; Varrone A
Conference publication: MOVEMENT DISORDERS. 2014;29:S71-S72

Examination of the dopamine transporter in striatum and substantia nigra in Parkinson's disease with [¹⁸F]FE-PE2I and high-resolution PET

Fazio P; Svenningsson P; Forsberg A; Jonsson EG; Amini N; Halldin C; Farde L; Varrone A
Review: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. 2013;40(3):267-279

Modeling of PET data in CNS drug discovery and development

Varnas K; Varrone A; Farde L
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2013;56:S310

Synthesis and evaluation of novel F-18 labeled deuterated fluororasagilineby PET to study MAO-B activity

Nag S; Lehmann L; Kettschau G; Thiele A; Varrone A; Toth M; Gulyas B; Dinkelborg L; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013;40:S302

Evaluation of Two Automated Methods for PET Region of Interest Analysis

Schain M; Varnas K; Cselenyi Z; Halldin C; Farde L; Varrone A
Conference publication: MOVEMENT DISORDERS. 2013;28:S173

Safety and efficacy of recombinant human platelet derived growth factor BB (rhPDGF-BB) in Parkinson's disease

Paul-Visse G; Zachrisson O; Varrone A; Almqvist P; Jerling M; Lind G; Rehncrona S; Linderoth B; Bjartmarz H; Svensson M; Mercer KJ; Forsberg A; Shafer LL; Lang AMJ; Halldin C; Svenningsson P; Widner H; Frisen J; Palhagen S; Haegerstrand A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012;39:S361

Test-retest of [11C]raclopride in rat: a PET/MRI study

Haggkvist J; Toth M; Doorduin J; Nagy K; Mathe D; Varrone A; Farde L; Halldin C; Gulyas B
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S63-S64

Visualizing the central 5-HT1B receptor with PET in rats: effects of cyclosporin A on [¹¹C]AZ10419369 uptake

Toth M; Haggkvist J; Doorduin J; Nagy K; Varrone A; Mathe D; Farde L; Gulyas B; Halldin C
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S61-S62

Test-retest variability of [¹¹C]raclopride in rat using PET/MRI

Haggkvist J; Toth M; Doorduin J; Nagy K; Mathe D; Varrone A; Farde L; Halldin C; Gulyas B
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S20-S21

Validation of SUV as an outcome measure of [¹¹C]PBR28 in rat using PET/MRI

Doorduin J; Haggkvist J; Toth M; Nagy K; Varrone A; Mathe D; Halldin C; Gulyas B
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S151

Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT

Schain M; Toth M; Cselenyi Z; Arakawa R; Halldin C; Farde L; Varrone A
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S113-S114

PET Imaging of VMAT2 with the novel radioligand [¹⁸F]FE-DTBZ-d4 in non-human primates: comparison with [¹¹C]DTBZ and [¹⁸F]FE-DTBZ

Varrone A; Jahan M; Toth M; Amini N; Nakao R; Halldin C
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S149-S151

Image derived input function using a multivariate analysis method based on pair-wise correlation between PET-image voxels

Schain M; Benjaminsson S; Varnas K; Forsberg A; Halldin C; Lansner A; Farde L; Varrone A
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S135-S136

Evaluation of two methods for automated PET region of interest analysis

Varnas K; Schain M; Cselenyi Z; Halldin C; Farde L; Varrone A
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2012;53

5-HT_1B receptor imaging in Parkinson's disease with ¹¹C-AZ10419369 and positron emission tomography

Varrone A; Svenningsson P; Forsberg A; Tiger M; Varnas K; Nilsson L-G; Halldin C; Farde L
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2012;53

Striatal dopamine transporter availability and body mass index in a large European sample of healthy subjects

van de Giessen E; Booij J; Caan M; Varrone A; Tatsch K; Hesse S; Sabri O
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2012;53

Association of serotonin transporter (SERT) availability and body mass index (BMI) in healthy Europeans

Hesse S; van de Giessen E; Zientek F; Varrone A; Tatsch K; Sabri O; Booij J
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S64

Characterization of [¹¹C]CIMBI-36 as a 5-HT_2A receptor agonist PET radioligand in the non-human primate brain

Finnema S; Ettrup A; Stepanov V; Nakao R; Amini N; Varrone A; Knudsen G; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2012;53

Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy studied by [11C] PE2I and PET using parent and metabolite combined arterial plasma input - A new approach

Odano I; Varrone A; Nakao R; Karlsson P; Savic I; Ciumas C; Halldin C; Farde L
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012;39:S182

Initial Evaluation of the Novel Dopamine Transporter Radioligand [18F]FE-PE2I in Healthy Controls and Parkinson's Disease Patients

Varrone A; Forsberg A; Nakao R; Amini N; Nag S; Svenningsson P; Halldin C; Farde L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2012;32:S101-S102

Synthesis and PET evaluation of a novel F-18 labeled deuterated fluorodeprenyl ([¹⁸F]fluorodeprenyl-D2) radioligand to study MAO-B activity

Nag S; Lehmann L; Kettschau G; Heinrich T; Thiele A; Varrone A; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2012;39:S267

Synthesis and Biological Evaluation of Novel F-18 Labeled Radioligands for Detection of MAO-B Activity

Nag S; Lehmann L; Kettschau G; Thiele A; Heinrich T; Varrone A; Gulyas B; Halldin C
Review: CLINICAL NEUROPHARMACOLOGY. 2011;34(3):95-100

Regional Cerebral Glucose Metabolism After Pridopidine (ACR16) Treatment in Patients With Huntington Disease

Esmaeilzadeh M; Kullingsjo J; Ullman H; Varrone A; Tedroff J
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2011;54:S269

Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel PET radioligand for MAO-B

Nag S; Lehmann L; Kettschau G; Thiele A; Varrone A; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38:S123

In Vivo Imaging of the 18-kDa Translocator Protein (TSPO) with [18F]FEDAA1106 and PET Does Not Show Increased Binding In Alzheimer's Disease Patients

Varrone A; Mattsson P; Forsberg A; Takano A; Nag S; Boellaard R; Al Tawil N; Joenhagen ME; Hoffmann A; Zimmermann T; Schultze-Mosgau M; Thiele A; Lammertsma AA; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38:S107

In vivo TSPO imaging in patients with Multiple Sclerosis: A PET study with [18F]FEDAA1106

Takano A; Piehl F; Hillert J; Varrone A; Nag S; Villemagne V; Rowe CC; Macdonell R; Al Tawil N; Kucunski T; Hoffmann A; Zimmermann T; Schultze-Mosgau M; Thiele A; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38:S188

Preliminary In Vivo Imaging of VMAT2 with The Novel PET Radioligand [18F]FE-DTBZ-d4 In Non-Human Primates: Comparison with [11C]DTBZ

Varrone A; Jahan M; Toth M; Nakao R; Halldin C
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2011;54:S311

D-Amphetamine decreases [¹¹C]AZ10419369 receptor binding in the monkey brain

Finnema SJ; Varrone A; Farde L; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2011;52

D-Amphetamine decreases 5-HT_1Breceptor binding of [¹¹C]AZ10419369 in the monkey brain

Finnema S; Varrone A; Farde L; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38:S256

ENCDAT Database of I123 FP-CIT Healthy Controls: Options for Implementation

Dickson JC; Soederlund TA; Tossici-Bolt L; Sera T; Booij J; Darcourt J; Jonsson C; Svarer C; Nobili F; Sabri O; Akdemir O; Koole M; George J; Tatsch K; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38:S257

Automatic semi-quantification of [123I] FP-CIT SPECT scans by means of BasGan -Version 2 in healthy volunteers. Results from the ENC-DAT database

Shoustari MN; Asenbaum S; Booij J; Ell P; Kapucu O; Kemp P; Knudsen GM; Pagani M; Sabri O; Tatsch K; Tossici-Bolt L; Borght TV; Van Laere K; Varrone A; Nobili F
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2011;54:S308

Quantitative measurement of [¹¹C]ORM-13070 receptor binding in the monkey brain using a bolus-infusion protocol

Finnema SJ; Nakao R; Haaparanta-Solin M; Varrone A; Stepanov V; Solin O; Ingman K; Sallinen J; Scheinin M; Farde L; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011;38:S147

D-Amphetamine decreases [¹¹C]ORM-13070 receptor binding in the monkey brain using a bolus-infusion protocol

Finnema SJ; Stepanov V; Varrone A; Nakao R; Haaparanta-Solin M; Solin O; Ingman K; Sallinen J; Scheinin M; Farde L; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2011;52

Pilot study on receptor binding and serotonin sensitivity of [¹¹C]CIMBI-36 in monkey brain

Finnema S; Ettrup A; Stepanov V; Nakao R; Yamamoto S; Varrone A; Knudsen G; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2011;52

A new quantitative approach for dopamine transporter binding using [11C]PE2I and PET allowing BBB-penetrating radiolabeled metabolite

Odano I; Varrone A; Nakao R; Karlsson P; Savic I; Ciumas C; Jucaite A; Halldin C; Farde L
Book chapter: METHODS OF CANCER DIAGNOSIS, THERAPY, AND PROGNOSIS: METHODS OF CANCER DIAGNOSIS, THERAPY AND PROGNOSIS. 2011;p. 9-19

Brain Tumor Imaging: European Association of Nuclear Medicine Procedure Guidelines

Borght TV; Asenbaum S; Bartenstein P; Halldin C; Kapucu Ö; Van Laere K; Varrone A; Tatsch K
Editorial comment: JOURNAL OF NUCLEAR MEDICINE. 2010;51(9):1331-1334

Molecular Imaging of the Dopamine Transporter

Varrone A; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S55

Confirmation of fenfluramine effect on 5-HT1B binding of [11C]AZ10419369 using an equilibrium approach

Finnema SJ; Varrone A; Hwang TJ; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S164-S165

Quantification of serotonin transporter availability with [11C]MADAM - A comparison between the ECAT HRRT and HR systems

Nilsson MS; Toth M; Cseleny Z; Karlsson P; Halldin C; Farde L; Varrone A
Meeting abstract: NEUROIMAGE. 2010;52:s118-s119

Quantification of [18F]LBT-999 binding to the dopamine transporter in the rhesus monkey brain with the HRRT system

Varrone A; Toth M; Stepanov V; Nakao R; Gulyas B; Emond P; Deloye JB; Vercouillie J; Halldin C; Guilloteau D
Meeting abstract: NEUROIMAGE. 2010;52:S61-S62

Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain

Finnema SJ; Varnas K; Stepanov V; Varrone A; Gulyas B; Arponen E; Helin S; Solin O; Haaparanta M; Sallinen J; Ingman K; Scheinin M; Farde L; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S168

Kinetic analysis and quantification of the dopamine transporter in the non-human primate brain with [11C]PE2I and [18F]FE-PE2I

Varrone A; Toth M; Steiger C; Takano A; Guilloteau D; Ichise M; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S121

Synthesis of three F-18 labeled analogues of 1-deprenyl for PET Studies of monoamine oxidase B

Nag S; Lehmann L; Kettschau G; Heinrich T; Brumby T; Thiele A; Varrone A; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2010;52:S100

PET studies in cynomolgous monkeys and whole hemisphere post mortem autoradiographic studies in human brain slices with the dopamine D2/D3 receptor ligand 11C-cariprazine

Toth M; Varrone A; Jia Z; Horvath A; Laszlovszky I; Kiss B; Halldin C; Gulyas B
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S299-S300

In vivo assessment of changes in serotonin release in the non-human primate brain using PET and [11C]AZ10419369

Finnema SJ; Varrone A; Hwang TJ; Farde L; Halldin C
Meeting abstract: SCHIZOPHRENIA RESEARCH. 2010;117(2-3):258-259

BRAIN DISTRIBUTION AND BINDING OF [¹¹C]CARIPRAZINE: IN VIVO PET STUDIES IN NON-HUMAN PRIMATES AND WHOLE HEMISPHERE POSTMORTEM AUTORADIOGRAPHIC STUDIES IN HUMAN BRAIN SLICES

Gulyas B; Toth M; Varrone A; Horvath A; Laszlovszky I; Kiss B; Halldin C
Editorial comment: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(2):434-442

EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2

Van Laere K; Varrone A; Booij J; Borght TV; Nobili F; Kapucu OL; Walker Z; Nagren K; Tatsch K; Darcourt J
Editorial comment: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37(2):443-450

EANM procedure guidelines for brain neurotransmission SPECT using ¹²³I-labelled dopamine transporter ligands, version 2

Darcourt J; Booij J; Tatsch K; Varrone A; Borght TV; Kapucu OL; Nagren K; Nobili F; Walker Z; Van Laere K
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S205

A Fluorine-18 Labeled Deprenyl PET Radioligand For in vivo Evaluation of MAO-B

Nag S; Lehmann L; Kettschau G; Heinrich T; Brumby T; Thiele A; Varrone A; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S274

Quantification, Biodistribution and Radiation Dosimetry of the Dopamine Transporter Radioligand [18F]FE-PE2I in Non-Human Primates

Varrone A; Toth M; Takano A; Steiger C; Guilloteau D; Jonsson C; Stabin MG; Ichise M; Gulyas B; Halldin C
Conference publication: BIOLOGICAL PSYCHIATRY. 2010;67(9):235S

Brain Distribution and Binding of 11C-Cariprazine: In Vivo PET Studies in Non-Human Primates and Whole Hemisphere Postmortem Autoradiographic Studies in Human Brain Slices

Gulyas B; Toth M; Varrone A; Horvath A; Laszlovszky I; Kiss B; Adham N; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S249

Improved methodology for measurement of serotonin release using [¹¹C]AZ10419369 and PET

Finnema SJ; Varrone A; Hwang T; Farde L; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2010;51

Dopamine transporter binding in patients with juvenile myoclonic epilepsy using [11C]PE2I and PET

Odano I; Varrone A; Ciumas C; Jucaite A; Halldin C; Farde L; Savic I
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2010;51

Confirmation of fenfluramine effect on 5-HT_1B binding of [¹¹C]AZ10419369 using an equilibrium approach

Finnema S; Varrone A; Hwang T-J; Farde L; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S275-S276

ENCDAT-European Database of I-123-FP-CIT SPECT Scans of Healthy Subjects: Final Results

Tatsch K; Varrone A; Tossici-Bolt L; Dickson JC; Sera T; Darcourt J; van Laere K
Conference publication: MOVEMENT DISORDERS. 2010;25:S676-S677

An Open-Label Safety, Efficacy, and Pharmacodynamic Investigation of SYN118 in Patients with Parkinson's Disease

Al-Tawil N; Tedroff J; Carlstrom C; Hallstrom Y; Varrone A; Meya U
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S274

Quantification, Biodistribution and Radiation Dosimetry of the Dopamine Transporter Radioligand [18F]LBT-999 in Non-Human Primates

Varrone A; Toth M; Stepanov V; Nakao R; Gulyas B; Emond P; Deloye JB; Vercouillie J; Jonsson C; Stabin MG; Guilloteau D; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S293-S294

A Comparison Between the ECAT HRRT and HR Systems in the Quantification of Serotonin Transporter Availability with [11C]MADAM

Schain M; Toth M; Cselenyi Z; Karlsson P; Halldin C; Farde L; Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2010;37:S250

Biodistribution and radiation dosimetry of the peripheral benzodiazepine receptor (PBR) radioligand [¹⁸F]FEDAA1106: a human whole-body PET study

Takano A; Gulyas B; Varrone A; Karlsson P; Sjoholm N; Larsson S; Odh R; Sparks R; Hoffmann A; Zimmermann T; Thiele A; Halldin C
Published conference paper: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(10):1639-1650

Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT

Varrone A; Sjoholm N; Eriksson L; Gulyas B; Halldin C; Farde L
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2009;29:S66

Fenfluramine decreases 5-HT_1B binding OF [¹¹C]AZ10419369 in the primate

Finnema SJ; Varrone A; Hwang TJ; Gulyas B; Pierson E; Farde L; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(SUPPL 2):257

A Comparative PET Study of the Two Norepinephrine Transporter Radioligands (S,S)-[¹⁸F]FMeNER-D₂ and (S,S)-^[11C]MeNER Using the Reference Tissue Model in the Rhesus Monkey

Takano A; Gulyas B; Varrone A; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36:S257

A Comparative PET Study of the Two Norepinephrine Transporter Radioligands (S,S)-[¹⁸F]FMeNER-D₂ and (S, S)[ ¹¹C]MeNER Using the Reference Tissue Model in the Rhesus Monkey

Takano A; Gulyas B; Varrone A; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36:S223

Kinetic Analysis and Quantification of the Dopamine Transporter in the Non-Human Primate Brain with [11C]PE2I and [18F]FE-PE2I

Varrone A; Steiger C; Toth M; Takano A; Guilloteau D; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36:S222

The 5-HT_1B radioligand [¹¹C]AZ10419369 is sensitive to endogenous serotonin levels in vivo

Finnema SJ; Varrone A; Hwang T; Gulyas B; Pierson E; Farde L; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2009;50

Effect of fenfluramine on 5-HT1B binding of [11C]AZ10419369 in the primate brain

Finnema S; Varrone A; Hwang T-J; Gulyas B; Pierson E; Farde L; Halldin C
Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2009;52:S76

EFFECT OF FENFLURAMINE ON 5-HT1B BINDING OF [11C]AZ10419369 IN THE PRIMATE BRAIN

Finnema SJ; Varrone A; Hwang TJ; Gulyas B; Pierson E; Farde L; Halldin C
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2009;50

Automated receptor imaging system (ARIS) in neuroreceptor binding studies with PET

Odano I; Sakaguchi K; Hosoya T; Varrone A; Savic I; Halldin C; Farde L
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36:S216

ENCDAT-European Database of I-123-FP-CIT SPECT Scans of Healthy Controls: First Results

Tatsch K; Varrone A; Tossici-Bolt L; Dickson JC; Sera T; Darcourt J; VanLaere K
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36:S182

¹²³I imaging of an anthropomorphic striatal phantom across different SPECT cameras: a European multicentre study

Tossici-Bolt L; Dickson JC; Sera T; Varrone A; Tatsch K
Meeting abstract: NEUROIMAGE. 2008;41:T144

Autoradiography and in vivo evaluation in cynomolgus monkey of [¹⁸F]FE-PE2I, a new dopamine transporter PET radioligand

Varrone A; Schou M; Steiger C; Takano A; Finnema S; Guilloteau D; Gulyas B; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T85

Advancement in PET quantification using 3D-OP-OSEM PSF reconstruction with the HRRT

Varrone A; Sjoholm N; Gulyas B; Halldin C; Farde L
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35:S304

99mTc-HMPAO distribution differences at SPECT between depressed females with and without adult ADHD

Pagani MME; Gardner A; Varrone A; Bejerot S; Sanchez-Crespo A; Danielsson A; Brolin F; Jacobsson H; Larsson S; Salmaso D
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35:S157

Direct Comparison of [11C]PE2I and [18F]FE-PE2I Dopamine Transporter PET Imaging in the Rhesus Monkey with the High-Resolution Research Tomograph, HRRT

Varrone A; Schou M; Steiger C; Takano A; Finnema S; Guilloteau D; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35:S145

Point Spread Function Reconstruction of High-Resolution Research Tomograph - HRRT - PET-Images Improves In Vivo Neuroreceptor Quantification

Varrone A; Sjoholm N; Gulyas B; Halldin C; Farde L
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35:S216

SPECT imaging of a ¹²³I striatal phantom on different cameras: relevance of scatter and septal penetration correction to quantification accuracy

Tossici-Bolt L; Dickson JC; Sera T; Varrone A; Tatsch K
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2008;15:394

Nuclear medicine beyond routine procedures. Differentiation of idiopathic and atypical parkinsonian syndromes

Varrone A
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2008;35:S157-S158

Measurement of norepinephrine transporter occupancy in nonhuman primate with (S,S)-[¹⁸F] FMeNER-D₂

Takano A; Gulyas B; Varrone A; Karlsson P; Maguire P; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T104

Quantitative analyses of [¹¹C]AZ10419369 binding to 5-HT_1B receptors in the human brain

Varnaes K; Nyberg S; Halldin C; Varrone A; Takano A; Karlsson P; McCarthy D; Smith M; Pierson ME; Soederstroem J; Farde L
Meeting abstract: NEUROIMAGE. 2008;41:T103

Mapping of the norepinephrine transporter in man using PET with (S,S)-[¹⁸F]FMeNER-D₂

Takano A; Varrone A; Gulyas B; Karlsson P; Tauscher J; Halldin C
Meeting abstract: NEUROIMAGE. 2008;41:T77

Automated system for parametric image analysis in neuroreceptor binding studies with PET

Odano I; Sakaguchi K; Hosoya T; Varrone A; Savic I; Halldin C; Farde L
Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34(7):1133-1134

FDOPA PET has clinical utility in brain tumour imaging:: a proposal for a revision of the recent EANM guidelines -: Reply

Vander Borght T; Asenbaum S; Bartenstein P; Halldin C; Kapucu O; Van Laere K; Varrone A; Tatsch K
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34:S206

Comparative evaluation of quantitative analysis of the norepinephrine transporter radioligand (S,S)-[¹⁸F]FMeNER-D₂ in monkey brains

Takano A; Varrone A; Seneca N; Tauscher J; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34:S205

In vivo measurement of acetylcholinesterase inhibition by Donepezil in cynomolgus monkey with [¹¹C]MP4A PET and reference tissue-based linear least square analysis

Varrone A; Takano A; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34:S205

Preliminary evaluation of a new dopamine transporter radioligand for PET imaging:: [¹⁸F]FE-PE2I

Varrone A; Schou M; Takano A; Steiger C; Finnema S; Chalon S; Emond P; Guilloteau D; Gulyas B; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34:S206

Brain and whole body distribution of the norepinephrine transporter radioligand (S,S)-[¹⁸F]FMeNER-D₂

Takano A; Gulyas B; Varrone A; Karlsson P; Sjoholm N; Schou M; Aieaksinen AJ; Tauscher J; Halldin C
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2007;61(6):490-491

Serotonin in anxiety:: PET study of sex differences

Jovanovic H; Lundberg J; Karlsson P; Cerin A; Saijo T; Varrone A; Halldin C; Nordstroem AL
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2007;34:S163

18F FDG PET-CT scan at staging and follow-up of patients with IE extranodal lymphoma compared with clinical and instrumental evaluation

Mainolfi CG; De Falco T; Varrone A; Caprio MG; Salvatore B; De Renzo A; Perna F; Panico MR; Pace L; Salvatore M
Conference publication: HAEMATOLOGICA. 2007;92:63-64

18F FDG PET-CT based staging of primary extranodal lymphomas compared to conventional modalities

Perna F; Mainolfi C; De Renzo A; De Falco T; Varrone A; Caprio MG; Salvatore B; Panico MR; Pane F; Pace L; Salvatore M; Rotoli B
Conference publication: NEUROLOGY. 2007;68(12):A158

Spinocerebellar ataxia 2: A brain diffusion weighted MRI study

Salvatore E; Mollica C; Ianniciello M; Varrone A; Sansone V; Salvatore M; De Michele G; Filla A; Pappata S
Review: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33(3):360-381

Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: the incremental value of nuclear medicine for patient management and care

Cuocolo A; Acampa W; Varrone A; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33:S305-S306

How much 18FDG is needed to scan a given number of oncologic patients with PET/CT?

Speranza A; Varrone A; Venetucci A; Storto G; Panico M; Russo A; Pace L; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33:S262

18F-FDG PET and PET/CT in the localization and characterization of lesions in patients with ovarian cancer

Caprio MG; Capacchione D; Mainolfi CG; Salvatore B; Varrone A; Cella L; Pace L; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33:S261

Role of FDG-PET/CT in the staging of colorectal cancer

Storto G; Mainenti P; Varrone A; Mainolfi C; Salvatore B; Caprio M; Cella L; Soricelli A; Pace L; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33:S261

18F-fdg pet, pet/ct and ce-mdct in locally advanced colorectal cancer

Caprio MG; Cantalupo T; Mainenti PP; Mainolfi CG; Varrone A; Salvatore B; Persico F; D'Antonio D; Pace L; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2006;33:S111

Longitudinal changes of dopamine transporter density in early-onset parkin disease measured with [¹²³I]FP-CIT SPECT

Varrone A; Sansone V; Pellecchia MT; Amboni M; Vitale C; Salvatore E; De Michele G; Garavaglia B; Annesi G; Brice A; Pappata S; Barone P; Salvatore M
Meeting abstract: NEUROIMAGE. 2006;31:t169

SPECT study of GABAA/BZD receptors and cerebral blood flow in mild cognitive impairment (MCI)

Pappata S; Varrone A; Milan G; Sansone V; Iavarone A; Panico MR; Quarantelli M; Mollica C; De Falco C; Lore E; Postiglione A; Salvatore M
Meeting abstract: NEUROIMAGE. 2006;31:t158

Imaging of the progression of nigrostriatal deficit in early-onset parkin disease with [123I]FP-CIT SPECT

Varrone A; Sansone V; Pellecchia MT; Amboni M; Vitale C; Salvatore E; De Michele G; Pappata S; Barone P; Salvatore M
Meeting abstract: NEUROIMAGE. 2006;31:T28

Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion:: A PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2

Seneca N; Gulyas B; Varrone A; Schou M; Tauscher J; Vandenhende F; Kielbasa W; Farde L; Innis RB; Halldin C
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2005;32:S64

Anterior Cingulate Hypoperfusion Can Differentiate Progressive Supranuclear Palsy From Parkinson's Disease; Voxel-Based Analysis And CBA-Based PCA Analysis Of 99mTc-ECD SPECT Data

Varrone A; Pagani M; Salmaso D; Salvatore E; Sansone V; Nobili F; Rodriguez G; Barone P; Larsson SA; De Michele G; Filla A; Pappata S; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2005;32:S189

Comparison Of A Dual-Headed And A Brain-Dedicated SPECT Camera In The Ability To Measure The Loss Of Dopamine Transporters With [123I]FP-CIT

Sansone V; Varrone A; Pellecchia MT; Amboni M; Salvatore E; De Michele G; Filla A; Barone P; Pappata S; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2005;32:S63

[123I]FP-CIT SPECT Study Of The Striatal Dopamine Transporter Density In Patients With Idiopathic Late Onset Cerebellar Ataxia And MSA-C

Varrone A; Salvatore E; Sansone V; De Michele G; Filla A; Pappata S; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2004;31:S360

Changes of regional cerebral blood flow in mild cognitive impairment studied with [99mTc]HMPAO SPET

Varrone A; Pappata S; Lorè E; Sansone V; Iavarone A; Carlomagno S; Brunetti A; Postiglione A; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2004;31:S218

Partial volume effect correction of rCBF SPET studies in mild cognitive impairment and Alzheimer's disease

Varrone A; Pappata S; Quarantelli M; Sansone V; Mollica C; Lorè E; Carlomagno S; Iavarone A; Postiglione A; Alfano B; Salvatore M
Conference publication: JOURNAL OF NEUROLOGY. 2004;251:186-187

Ataxia with oculomotor apraxia type I (AOA1) in southern Italy

Criscuolo C; Mancini P; De Michele G; Salvatore E; Varrone A; Saccà F; Scarano V; Banfi S; Filla A
Conference publication: NEUROLOGY. 2004;62(7):A46

AOA1:: Phenotypic variability and identification of a new mutation in a southern Italian population

Criscuolo C; De Michele G; Mancini P; Salvatore E; Varrone A; Saccà F; Monticelli A; Banfi S
Conference publication: MOVEMENT DISORDERS. 2004;19:S255

Imaging of dopaminergic dysfunction with [¹²³I]FP-CIT SPECT in early-onset Parkinson's disease

Varrone A; Pappatà S; Amboni M; Pellecchia M; Salvatore E; Salvatore M
Published conference paper: RIVISTA DI NEURORADIOLOGIA. 2003;16:223-224

Disorders in cortical development and epilepsy - 13 years of experience

Elefante A; Ruosi P; Tortora F; Caranci F; Striano P; Varrone A; Briganti F; Striano S; Cirillo S; Elefante R
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2002;43(5):215P-216P

Comparison of FBP and OSEM in quantitative dopamine SPECT with scatter correction.

Kim KM; Watabe H; Varrone A; Fujita M; Innis RB; Iida H
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2001;28(8):1088

Voxel-based comparison of 99mTc-HMPAO SPECT images in Alzheimer and fronto-temporal dementia revealed distinct patterns of CBF alterations

Pappatà S; Varrone A; Caracò C; Soricelli A; Brunetti A; Milan G; Postiglione A; Alfano B; Salvatore M
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2001;28(8):988

Predictive value of clinical evaluation and I-123 beta-CIT SPECT imaging for the diagnosis of Parkinson's disease and multiple system atrophy

Varrone A; Marek KL; Jennings D; Innis RB; Seibyl JP
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2001;28(8):987

Measuring progression of dopamine transporter loss in hemi-Parkinson's disease with I-123 beta-CIT SPECT

Varrone A; Marek KL; Jennings D; Innis RB; Seibyl JP
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2001;42(5):217P

Effect of scatter correction in the measurement of striatal and extrastriatal dopamine D2 receptors using ¹²³Iepidepride SPECT.

Fujita M; Varrone A; Kim KM; Watabe H; Zoghbi SS; Baldwin RM; Seneca N; Seibyl JP; Innis RB; Iida H
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2001;42(5):184P

Effect of scatter correction on quantitative estimation in receptor ligand study with SPECT.

Kim KM; Watabe H; Shidahara M; Varrone A; Fujita M; Innis RB; Iida H
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2000;41(5):210P

Effects of dopamine depletion on in vivo binding of [¹¹C] NCC-112 to D1 receptors.

Varrone A; Garg P; Al-Tikriti MS; Fu X; Anderson G; Halldin C; Malison RT; Seibyl JP; Innis RB
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2000;41(5):138P

Imaging of dopamine transporters with [¹²³I]β-CIT SPECT in Parkinson' s disease and multiple system atrophy:: Comparison with clinical evaluation.

Varrone A; Marek KL; Jennings D; Innis RB; Seibyl JP
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 2000;41(5):38P

Labeling, dopamine transporter affinity, and brain uptake of the first cyclo-pentadienyltricarbonyl-[^99mTechnetium]- tropane conjugate.

Tamagnan GD; Cesati RR; Zoghbi SS; Varrone A; Al-Tikriti MS; Seibyl JP; Kula NS; Baldessarini RJ; Katzellenbogen JA; Innis RB; Baldwin RM
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 1999;26(9):1001

123I-iomazenil SPECT scans in patients with transient ischemic attacks (TIA): Preliminary evaluation

Soricelli A; Varrone A; Brunetti A; Pinto AM; Ciarmiello A; Tedeschi G; Salvatore M
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1999;40(5):67P

Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [I-123]epidepride SPECT in humans.

Varrone A; Fujita M; Verhoeff NP; Zoghbi SS; Baldwin RM; Seibyl JP; Innis RB
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1999;40(5):31P

Imaging of extrastriatal D₂ receptor occupancy by endogenous dopamine in humans.

Fujita M; Verhoeff NP; Varrone A; Zoghbi SS; Baldwin RM; Rajeevan N; Seibyl JP; Charney DS; Innis RB
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1998;39(5):14P

Evaluation of patients with parkinsonism with [I-123] IBF and β-CIT SPECT.

Varrone A; Innis RB; Marek K; Zoghbi S; Baldwin R; Seibyl JP
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1998;39(5):101P

Prognostic value of combined assessment of left ventricular function and regional myocardial thallium-201 activity in patients with chronic ischemic left ventricular dysfunction.

Cuocolo A; Petretta M; Nicolai E; Acampa W; Varrone A; Bonaduce D; Salvatore M
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1998;39(5):17P

Direct comparison of technetium-99m labeled sestamibi and tetrofosmin cardiac tomography in patients with coronary artery disease.

Cuocolo A; Acampa W; Varrone A; Sullo P; Nicolai E; Pace L; Salvatore M
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1997;38(5):715

Prognostic value of coronary angiography in patients with chronic ischemic left ventricular dysfunction and evidence of viable myocardium at thallium-201 reinjection imaging.

Cuocolo A; Petretta M; Nicolai E; Pace L; Acampa W; Varrone A; Bonaduce D; Salvatore M
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1997;38(5):704

Exercise capacity and left ventricular function at rest in patients with heart failure.

Pace L; Nappi A; Cuocolo A; Varrone A; Romano M; Salvatore M
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1997;38(5):226

Effects of revascularization on survival and left ventricular function in patients with previous myocardial infarction and evidence of viable myocardium at thallium-201 imaging.

Cuocolo A; Nicolai E; Petretta M; Pace L; Cardei S; Varrone A; Trimarco B; Salvatore M
Conference publication: RADIOLOGY. 1996;201:1481

Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease

Soricelli A; Varrone A; Acampa W; Postiglione A; Salvatore M; Lassen N
Conference publication: JOURNAL OF NUCLEAR MEDICINE. 1996;37(5):716

Preliminary evaluation of distribution volume for 123I-iomazenil in Alzheimer's disease as a measure of neuronal loss.

Soricelli A; Postiglione A; Mainenti PP; GrivetFojaja MR; Discepolo A; Varrone A; Salvatore M; Lassen NA
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Forskningsbidrag

Development of PET tracer for imaging SV2C in Parkinson´s disease

Michael J. Fox Foundation for Parkinson's Research

1 January 2023 - 31 December 2025
The human brain after surgery and trauma - neuroinflammation, neurocognitive decline and dementia

Swedish Research Council

1 January 2021 - 31 December 2023
Development of an imaging marker for synaptic vesicular glycoprotein SV2C: a specific target for synaptic density in Parkinson´s disease

Swedish Research Council

1 January 2021 - 31 December 2023
Preklinisk utvärdering av [3H]KAC-50.1, en alfa-synuclein PET markör för Parkinsons sjukdom

Parkinsonfonden

13 October 2020 - 31 March 2024
Mechanisms of Cognitive Aging: The Roles of Brain Iron Accumulation and Neuroinflammation

Swedish Research Council

1 January 2020 - 31 December 2023
[18F]FE-PE2I PET: a novel biomarker for Parkinson’s disease

Deutsche Forschungsgemeinschaft

1 January 2019 - 31 December 2021
In vitro characterization of potential PET radioligands for imaging alpha-synuclein

VINNOVA

3 July 2017 - 30 June 2018
PET-study of the time course for dopaminergic degeneration in Parkinson´s disease

Swedish Research Council

1 January 2017 - 31 December 2019
PET studies of the glutamate system in schizophrenia

Swedish Research Council

1 January 2016 - 31 December 2019

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