Ali Mahdi

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: ANTIOXIDANTS. 2026;15(1):58
Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia-Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes
Yang J; Tratsiakovich Y; Cao R; Mahdi A; Pironti G; Jiao T; Humoud R; Kontidou E; Tengbom J; Collado A; Zhou Z; Cao Y; Kohler E; Mullick AE; Pernow J
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2025;61(12):1904-1912
Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study
Ebrahimi R; Ebrahimi F; Niess JH; Mahdi A; Chen S; Di Vece D; Bian W; Kutz A; Forss A
Article: AMERICAN JOURNAL OF MEDICINE. 2025;138(6):1019-1028
Post-Acute COVID-19 Syndrome: Prevalence of Peripheral Microvascular Endothelial Dysfunction and Associations With NT-ProBNP Dynamics
Stahlberg M; Fischer K; Tahhan M; Zhao A; Fedorowski A; Runold M; Nygren-Bonnier M; Bjornson M; Lund LH; Bruchfeld J; Desta L; Braunschweig F; Mahdi A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;135(10):e180900
Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes
Collado A; Humoud R; Kontidou E; Eldh M; Swaich J; Zhao A; Yang J; Jiao T; Domingo E; Carlestal E; Mahdi A; Tengbom J; Vegvari A; Deng Q; Alvarsson M; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(2):417-431
miR-210 as a therapeutic target in diabetes-associated endothelial dysfunction
Collado A; Jiao T; Kontidou E; Carvalho LRRA; Chernogubova E; Yang J; Zaccagnini G; Zhao A; Tengbom J; Zheng X; Rethi B; Alvarsson M; Catrina S-B; Mahdi A; Carlstroem M; Martelli F; Pernow J; Zhou Z
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(6):H1431-H1441
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction
Tengbom J; Humoud R; Kontidou E; Jiao T; Yang J; Hedin U; Zhou Z; Jurga J; Collado A; Mahdi A; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.3685
Increased endothelial cell uptake of erythrocyte-derived extracellular vesicles carrying arginase-1 induces endothelial dysfunction in type 2 diabetes
Collado A; Humoud R; Kontidou E; Swaich J; Yang J; Mahdi A; Tengbom J; Zhou Z; Pernow J
Article: CLINICAL SCIENCE. 2024;138(15):975-985
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase
Tengbom J; Kontidou E; Collado A; Yang J; Alvarsson M; Brinck J; Rossner S; Zhou Z; Pernow J; Mahdi A
Journal article: CARDIOVASCULAR RESEARCH. 2024;120:cvae088.035
Red blood cell-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through a mechanism involving arginase 1
Collado A; Humoud R; Kontidou E; Eldh M; Yang J; Jiao T; Domingo E; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(Suppl_1):a1127
Abstract 1127: Erythrocyte Derived Extracellular Vesicles From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Through Increased Vascular Oxidative Stress
Collado A; Humoud R; Kontidou E; Yang J; Jiao T; Mahdi A; Zhou Z; Pernow J
Article: ATHEROSCLEROSIS. 2024;389:117439
Higher prevalence of coronary microvascular dysfunction in asymptomatic individuals with high levels of lipoprotein(a) with and without heterozygous familial hypercholesterolaemia
Wodaje T; Mahdi A; Venkateshvaran A; Habel H; Zenlander R; Gaylard B; Angelin B; Pernow J; Brinck J
Article: CARDIOLOGY RESEARCH AND PRACTICE. 2023;2023:6687803-9
Enhanced External Counterpulsation for Management of Postacute Sequelae of SARS-CoV-2 Associated Microvascular Angina and Fatigue: An Interventional Pilot Study
Wu E; Mahdi A; Nickander J; Bruchfeld J; Mellbin L; Haugaa K; Stahlberg M; Desta L
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2023;21(13):3356-3364.e9
Patients With Microscopic Colitis Are at Higher Risk of Major Adverse Cardiovascular Events: A Matched Cohort Study
Forss A; Bergman D; Roelstraete B; Sundstroem J; Mahdi A; Khalili H; Ludvigsson JF
Article: SCIENTIFIC REPORTS. 2023;13(1):20230
Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study
Mahdi A; Zhao A; Fredengren E; Fedorowski A; Braunschweig F; Nygren-Bonnier M; Runold M; Bruchfeld J; Nickander J; Deng Q; Checa A; Desta L; Pernow J; Stahlberg M
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3099
Paracrine cardioprotective signaling by red blood cells through hypoxia-mediated activation of soluble guanylate cyclase and release of cyclic guanosine monophosphate
Yang JN; Sundqvist M; Zheng X; Jiao T; Collado A; Mahdi A; Tengbom J; Mergia E; Zhou Z; Carlstrom M; Akaike T; Cortese-Krott M; Weitzberg E; Lundberg JO; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3096
Stimulation of soluble guanylyl cyclase in erythrocytes induces export of cGMP and cardioprotection in type 2 diabetes
Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne G; Alvarsson M; Lundberg J; Zhou Z; Yang J; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3066
Erythrocyte-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through arginase 1
Collado A; Humoud R; Eldh M; Jiao T; Domingo E; Kontidou E; Yang J; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693
Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP
Yang J; Sundqvist ML; Zheng X; Jiao T; Collado A; Tratsiakovich Y; Mahdi A; Tengbom J; Mergia E; Catrina S-B; Zhou Z; Carlstroem M; Akaike T; Cortese-Krott MM; Weitzberg E; Lundberg JO; Pernow J
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2023;8(8):907-918
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes
Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne GT; Alvarsson M; Lundberg JO; Zhou Z; Yang J; Pernow J
Journal article: EUROPACE. 2023;25(Supplement_1):euad122.226
Postural orthostatic tachycardia syndrome associated with post-acute covid-19 syndrome is not mediated through smaller hearts or contractile dysfunction
Ahmad A; Mahdi A; Fedorowski A; Nygren-Bonnier M; Bruchfeldt J; Runold M; Desta L; Pernow J; Stahlberg M; Nickander J
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Alla övriga publikationer

Review: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. 2024;35(3):608-617
Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection
Stahlberg M; Mahdi A; Johansson M; Fedorowski A; Olshansky B
Meeting abstract: CIRCULATION. 2023;148:a16646
Evidence of Protein Dysregulation in Patients With Post-Acute COVID-19 Syndrome With- and Without Postural Orthostatic Tachycardia Syndrome
Zhao A; Mahdi A; Fredengren E; Fedorowski A; Braunschweig F; Brodin P; Nygren-Bonnier M; Runold M; Bruchfeld J
Letter: CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY. 2023;16(7):413-414
Microvasular Dysfunction and Reduced Cardiac Stress Reactivity in Postural Orthostatic Tachycardia Associated With Postacute COVID-19
Mahdi A; Lodin K; Reistam U; Fedorowski A; Nygren-Bonnier M; Runold M; Bruchfeld J; Desta L; Pernow J; Nickander J; Stahlberg M
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2917
Red blood cells induce endothelial dysfunction in patients with ST-elevation myocardial infarction and elevated C-reactive protein
Tengbom J; Collado A; Jiao T; Yang J; Zhou Z; Mahdi A; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2910
Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection via the purinergic P2Y13 receptor and nitric oxide signalling
Jiao T; Mahdi A; Tengbom J; Collado A; Jurga J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
Doctoral thesis: 2021
The red blood cell as a mediator of vascular dysfunction in type 2 diabetes and COVID-19
Mahdi AJ
Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3259
Attenuated cardiac post-ischemic injury and endothelial dysfunction by stimulation of soluble guanylyl cyclase in red blood cells from patients with type 2 diabetes
Jiao T; Zhou Z; Mahdi A; Tengbom J; Tratsiakovich Y; Yang J; Pernow J
Editorial: DRUG DISCOVERY TODAY. 2021;26(8):1773-1775
Sunitinib and its effect in the cardiovascular system
Mahdi A; Wernly B; Pernow J; Zhou Z
Review: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2020;301:207-214
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Mahdi A; Kovamees O; Pernow J
Review: CARDIOVASCULAR RESEARCH. 2019;115(11):1596-1605
Red blood cell dysfunction: a new player in cardiovascular disease
Pernow J; Mahdi A; Yang J; Zhou Z
Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42
Vascular endothelial growth factor receptor 2 inhibition improves endothelial function in type 2 diabetic rats: a link to purinergic signalling?
Mahdi A; Tratsiakovich Y; Yang J; Ostenson C-G; Danser JAH; Pernow J; Zhou Z
Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S26-S27
Inorganic nitrate restores cardiac ischemic tolerance in type 2 diabetic db/db mice and protects against ischemia-reperfusion injury via an effect mediated through red blood cells
Yang JN; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42
Red blood cells from patients with type 2 diabetes mellitus induce endothelial dysfunction through NADPH oxidase-derived reactive oxygen species
Zhou Z; Mahdi A; Tratsiakovich Y; Yang J; Pernow J

Forskningsbidrag

The importance of microvascular endothelial dysfunction for acute and long-term complications of COVID-19: clinical and mechanistic insights
Swedish Heart-Lung Foundation
1 januari 2021 - 31 december 2021
The importance of vascular and red blood cell arginase for cardiovascular perturbations in diabetes, obesity and hyperlipidemia.
Swedish Heart-Lung Foundation
1 januari 2020 - 31 december 2021

Anställningar

Anknuten till Forskning, Medicin, Solna, Karolinska Institutet, 2025-2028

Examina och utbildning

Medicine Doktorsexamen, Institutionen för medicin, Solna, Karolinska Institutet, 2021
Läkarexamen, Karolinska Institutet, 2019

Artiklar

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Anställningar

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Nyheter från KI

Kalenderhändelser från KI