Ali Mahdi

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Articles

Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(6):H1431-H1441
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction.
Tengbom J; Humoud R; Kontidou E; Jiao T; Yang J; Hedin U; Zhou Z; Jurga J; Collado A; Mahdi A; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.3685
Increased endothelial cell uptake of erythrocyte-derived extracellular vesicles carrying arginase-1 induces endothelial dysfunction in type 2 diabetes
Collado A; Humoud R; Kontidou E; Swaich J; Yang J; Mahdi A; Tengbom J; Zhou Z; Pernow J
Article: AMERICAN JOURNAL OF MEDICINE. 2024;:S0002-9343(24)00642-9
Post-Acute COVID-19 Syndrome: Prevalence of Peripheral Microvascular Endothelial Dysfunction and Associations with NT-ProBNP Dynamics.
Ståhlberg M; Fischer K; Tahhan M; Zhao A; Fedorowski A; Runold M; Nygren-Bonnier M; Björnson M; Lund LH; Bruchfeld J; Desta L; Braunschweig F; Mahdi A
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024;182(2):417-431
miR-210 as a therapeutic target in diabetes-associated endothelial dysfunction
Collado A; Jiao T; Kontidou E; Carvalho LRRA; Chernogubova E; Yang J; Zaccagnini G; Zhao A; Tengbom J; Zheng X; Rethi B; Alvarsson M; Catrina S-B; Mahdi A; Carlstroem M; Martelli F; Pernow J; Zhou Z
Article: CLINICAL SCIENCE. 2024;138(15):975-985
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase
Tengbom J; Kontidou E; Collado A; Yang J; Alvarsson M; Brinck J; Rossner S; Zhou Z; Pernow J; Mahdi A
Journal article: CARDIOVASCULAR RESEARCH (CVR). 2024;120:cvae088.035
Red blood cell-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through a mechanism involving arginase 1
Collado A; Humoud R; Kontidou E; Eldh M; Yang J; Jiao T; Domingo E; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2024;44(Suppl_1):a1127
Abstract 1127: Erythrocyte Derived Extracellular Vesicles From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Through Increased Vascular Oxidative Stress
Collado A; Humoud R; Kontidou E; Yang J; Jiao T; Mahdi A; Zhou Z; Pernow J
Article: ATHEROSCLEROSIS. 2024;389:117439
Higher prevalence of coronary microvascular dysfunction in asymptomatic individuals with high levels of lipoprotein(a) with and without heterozygous familial hypercholesterolaemia
Wodaje T; Mahdi A; Venkateshvaran A; Habel H; Zenlander R; Gaylard B; Angelin B; Pernow J; Brinck J
Article: CARDIOLOGY RESEARCH AND PRACTICE. 2023;2023:6687803-9
Enhanced External Counterpulsation for Management of Postacute Sequelae of SARS-CoV-2 Associated Microvascular Angina and Fatigue: An Interventional Pilot Study
Wu E; Mahdi A; Nickander J; Bruchfeld J; Mellbin L; Haugaa K; Stahlberg M; Desta L
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2023;21(13):3356-3364.e9
Patients With Microscopic Colitis Are at Higher Risk of Major Adverse Cardiovascular Events: A Matched Cohort Study
Forss A; Bergman D; Roelstraete B; Sundstroem J; Mahdi A; Khalili H; Ludvigsson JF
Article: SCIENTIFIC REPORTS. 2023;13(1):20230
Dysregulations in hemostasis, metabolism, immune response, and angiogenesis in post-acute COVID-19 syndrome with and without postural orthostatic tachycardia syndrome: a multi-omic profiling study
Mahdi A; Zhao A; Fredengren E; Fedorowski A; Braunschweig F; Nygren-Bonnier M; Runold M; Bruchfeld J; Nickander J; Deng Q; Checa A; Desta L; Pernow J; Stahlberg M
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3099
Paracrine cardioprotective signaling by red blood cells through hypoxia-mediated activation of soluble guanylate cyclase and release of cyclic guanosine monophosphate
Yang JN; Sundqvist M; Zheng X; Jiao T; Collado A; Mahdi A; Tengbom J; Mergia E; Zhou Z; Carlstrom M; Akaike T; Cortese-Krott M; Weitzberg E; Lundberg JO; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3096
Stimulation of soluble guanylyl cyclase in erythrocytes induces export of cGMP and cardioprotection in type 2 diabetes
Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne G; Alvarsson M; Lundberg J; Zhou Z; Yang J; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.3066
Erythrocyte-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through arginase 1
Collado A; Humoud R; Eldh M; Jiao T; Domingo E; Kontidou E; Yang J; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Journal article: CIRCULATION. 2023;148:a16646
Evidence of Protein Dysregulation in Patients With Post-Acute COVID-19 Syndrome With- and Without Postural Orthostatic Tachycardia Syndrome
Zhao A; Mahdi A; Fredengren E; Fedorowski A; Braunschweig F; Brodin P; Nygren-Bonnier M; Runold M; Bruchfeld J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(17):e167693
Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP
Yang J; Sundqvist ML; Zheng X; Jiao T; Collado A; Tratsiakovich Y; Mahdi A; Tengbom J; Mergia E; Catrina S-B; Zhou Z; Carlstroem M; Akaike T; Cortese-Krott MM; Weitzberg E; Lundberg JO; Pernow J
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2023;8(8):907-918
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes
Jiao T; Collado A; Mahdi A; Tengbom J; Tratsiakovich Y; Milne GT; Alvarsson M; Lundberg JO; Zhou Z; Yang J; Pernow J
Journal article: EUROPACE. 2023;25(Supplement_1):euad122.226
Postural orthostatic tachycardia syndrome associated with post-acute covid-19 syndrome is not mediated through smaller hearts or contractile dysfunction
Ahmad A; Mahdi A; Fedorowski A; Nygren-Bonnier M; Bruchfeldt J; Runold M; Desta L; Pernow J; Stahlberg M; Nickander J
Journal article: EUROPACE. 2023;25(Supplement_1):euad122.597
Evidence of cytokine activation in patients with post-acute COVID-19 syndrome with- and without postural orthostatic tachycardia syndrome
Fredengren E; Mahdi A; Fedorowski A; Brodin P; Nygren-Bonnier M; Runold M; Bruchfeld J; Nickander J; Desta L; Pernow J; Stahlberg M
Journal article: GASTROENTEROLOGY. 2023;164(6):s-427
Sa1778 PATIENTS WITH MICROSCOPIC COLITIS ARE AT INCREASED RISK OF INCIDENT MAJOR ADVERSE CARDIOVASCULAR EVENTS: A NATIONWIDE HISTOPATHOLOGY MATCHED COHORT STUDY
Forss A; Bergman D; Roelstraete B; Sundstrom J; Mahdi A; Khalili H; Ludvigsson JF
Article: JOURNAL OF INTERNAL MEDICINE. 2023;293(2):228-245
The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia
Mahdi A; Wodaje T; Kovamees O; Tengbom J; Zhao A; Jiao T; Henricsson M; Yang J; Zhou Z; Nieminen AI; Levin M; Collado A; Brinck J; Pernow J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;194:308-315
Decreased oxidative stress and altered urinary oxylipidome by intravenous omega-3 fatty acid emulsion in a randomized controlled trial of older subjects hospitalized for COVID-19
Pawelzik S-C; Arnardottir H; Sarajlic P; Mahdi A; Vigor C; Zurita J; Zhou B; Kolmert J; Galano J-M; Religa D; Durand T; Wheelock CE; Back M
Journal article: CIRCULATION. 2022;146(Suppl_1):a12760
Abstract 12760: Microvascular Endothelial Dysfunction in Postural Orthostatic Tachycardia Syndrome Associated With Post-Acute Sequelae of COVID-19
Mahdi A; Reistam U; Nickander J; Fedorowski A; Desta L; Nygren-Bonnier M; Runold M; Bruchfeld J; Pernow J; Stahlberg M
Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2022;323(5):H1004-H1009
The protective effect of remote ischemic conditioning is lost in patients with hypercholesterolemia
Kovamees O; Mahdi A; Wodaje T; Verouhis D; Brinck J; Pernow J
Article: BASIC RESEARCH IN CARDIOLOGY. 2022;117(1):46
Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection through the purinergic P2Y₁₃ receptor and nitric oxide signaling
Jiao T; Collado A; Mahdi A; Jurga J; Tengbom J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
Article: BIOCHEMICAL PHARMACOLOGY. 2022;201:115075
The resolvin D2-GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice
Bardin M; Pawelzik S-C; Lagrange J; Mahdi A; Arnardottir H; Feve B; Regnault V; Lacolley P; Michel J-B; Mercier N; Back M
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2022;7(3):193-204
Erythrocytes Induce Vascular Dysfunction in COVID-19
Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Johansson N; Farnebo F; Farnert A; Yang J; Lundberg JO; Zhou Z; Pernow J
Article: DIABETES. 2022;71(2):285-297
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: PHARMACOLOGY. 2022;107(3-4):160-166
Therapeutic Potential of Sunitinib in Ameliorating Endothelial Dysfunction in Type 2 Diabetic Rats
Mahdi A; Jiao T; Tratsiakovich Y; Wernly B; Yang J; Ostenson C-G; Danser AHJ; Pernow J; Zhou Z
Journal article: EUROPEAN HEART JOURNAL. 2021;42(Supplement_1):ehab724.1205
Remote ischemic conditioning fails to protect against ischemia-reperfusion injury in patients with untreated familial hypercholesterolemia
Kovamees O; Mahdi A; Wodaje T; Verouhis D; Brinck J; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2021;42(Supplement_1):ehab724.3364
Erythrocytes induce vascular dysfunction in COVID-19
Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Yang J; Lundberg JO; Zhou Z; Pernow J
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2021;168:95-109
Novel perspectives on redox signaling in red blood cells and platelets in cardiovascular disease
Mahdi A; Cortese-Krott MM; Kelm M; Li N; Pernow J
Article: CELLS. 2020;9(7):E1712-1712
Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase
Mahdi A; Tengbom J; Alvarsson M; Wernly B; Zhou Z; Pernow J
Article: ATHEROSCLEROSIS. 2020;292:215-223
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques
Rafnsson A; Matic LP; Lengquist M; Mahdi A; Shemyakin A; Paulsson-Berne G; Hansson GK; Gabrielsen A; Hedin U; Yang J; Pernow J
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:603226
Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling
Mahdi A; Tratsiakovich Y; Tengbom J; Jiao T; Garib L; Alvarsson M; Yang J; Pernow J; Zhou Z
Article: REJUVENATION RESEARCH. 2019;22(5):385-389
Arginase Inhibition Improves Endothelial Function in an Age-Dependent Manner in Healthy Elderly Humans
Mahdi A; Pernow J; Kovamees O
Journal article: EUROPEAN HEART JOURNAL. 2019;40(Supplement_1):ehz746.0897
P6299Dietary nitrate restores cardiac ischemic tolerance in type 2 diabetic mice and protects against ischemia-reperfusion injury via soluble guanylate cyclase in red blood cells
Yang JN; Jiao T; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
Journal article: THE FASEB JOURNAL. 2019;33:512.4
Sunitinib Improves Endothelial Function in Type 2 Diabetic Rats
Zhou Z; Mahdi A; Tratsiakovich Y; Jiao T; Yang J; Ostenson C-G; Danser AHJ; Pernow J
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:861
The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes
Mahdi A; Jiao T; Yang J; Kovamees O; Alvarsson M; von Heijne M; Zhou Z; Pernow J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(12):E3942-3942
Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up₄A-Mediated Vascular Contraction
Mahdi A; Jiao T; Tratsiakovich Y; Yang J; Ostenson C-G; Pernow J; Zhou Z
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):388-398
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy
Mahdi A; Kovamees O; Checa A; Wheelock CE; von Heijne M; Alvarsson M; Pernow J
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(7):769-780
Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I
Zhou Z; Mahdi A; Tratsiakovich Y; Zahoran S; Kovamees O; Nordin F; Gonzalez AEU; Alvarsson M; Ostenson C-G; Andersson DC; Hedin U; Hermesz E; Lundberg JO; Yang J; Pernow J
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463
Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species
Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kovamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy565.p2619
P2619Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose lowering therapy
Mahdi A; Kovamees O; Von Heijne M; Alvarsson M; Pernow J
Article: ACTA PHYSIOLOGICA. 2017;221(3):174-181
Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha-7 nicotinic acetylcholine receptor and downregulation of cardiac and vascular arginase
Kiss A; Tratsiakovich Y; Mahdi A; Yang J; Gonon AT; Podesser BK; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx493.p5386
P5386Red blood cells from patients with type 2 diabetes impair post-ischemic cardiac recovery via a mechanism depending on arginase and nitric oxide synthase
Yang JN; Mahdi A; Zhou Z; Tratsiakovich Y; Kovamees O; Alvarsson M; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2017;38(suppl_1):ehx501.280
280Red blood cells from patients with type 2 diabetes mellitus induce vascular endothelial dysfunction via a mechanism involving vascular arginase I and reactive oxygen species
Zhou Z; Mahdi A; Tratsiakovich Y; Kovamees O; Alvarsson M; Yang J; Pernow J
Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2017;37(suppl_1)
Abstract 378: Red Blood Cells From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Through Up-Regulation of Arginase I
Zhou Z; Mahdi A; Tratsiakovich Y; Kövamees O; Yang J; Pernow J
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All other publications

Review: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. 2024;35(3):608-617
Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection
Stahlberg M; Mahdi A; Johansson M; Fedorowski A; Olshansky B
Letter: CIRCULATION: ARRHYTHMIA AND ELECTROPHYSIOLOGY. 2023;16(7):413-414
Microvasular Dysfunction and Reduced Cardiac Stress Reactivity in Postural Orthostatic Tachycardia Associated With Postacute COVID-19
Mahdi A; Lodin K; Reistam U; Fedorowski A; Nygren-Bonnier M; Runold M; Bruchfeld J; Desta L; Pernow J; Nickander J; Stahlberg M
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2917
Red blood cells induce endothelial dysfunction in patients with ST-elevation myocardial infarction and elevated C-reactive protein
Tengbom J; Collado A; Jiao T; Yang J; Zhou Z; Mahdi A; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2910
Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection via the purinergic P2Y13 receptor and nitric oxide signalling
Jiao T; Mahdi A; Tengbom J; Collado A; Jurga J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
Thesis / dissertation: 2021
The red blood cell as a mediator of vascular dysfunction in type 2 diabetes and COVID-19
Mahdi, Ali
Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3259
Attenuated cardiac post-ischemic injury and endothelial dysfunction by stimulation of soluble guanylyl cyclase in red blood cells from patients with type 2 diabetes
Jiao T; Zhou Z; Mahdi A; Tengbom J; Tratsiakovich Y; Yang J; Pernow J
Editorial comment: DRUG DISCOVERY TODAY. 2021;26(8):1773-1775
Sunitinib and its effect in the cardiovascular system
Mahdi A; Wernly B; Pernow J; Zhou Z
Review: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2020;301:207-214
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Mahdi A; Kovamees O; Pernow J
Review: CARDIOVASCULAR RESEARCH (CVR). 2019;115(11):1596-1605
Red blood cell dysfunction: a new player in cardiovascular disease
Pernow J; Mahdi A; Yang J; Zhou Z
Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S42
Vascular endothelial growth factor receptor 2 inhibition improves endothelial function in type 2 diabetic rats: a link to purinergic signalling?
Mahdi A; Tratsiakovich Y; Yang J; Ostenson C-G; Danser JAH; Pernow J; Zhou Z
Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S42
Red blood cells from patients with type 2 diabetes mellitus induce endothelial dysfunction through NADPH oxidase-derived reactive oxygen species
Zhou Z; Mahdi A; Tratsiakovich Y; Yang J; Pernow J
Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S26-S27
Inorganic nitrate restores cardiac ischemic tolerance in type 2 diabetic db/db mice and protects against ischemia-reperfusion injury via an effect mediated through red blood cells
Yang JN; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J

Grants

The importance of microvascular endothelial dysfunction for acute and long-term complications of COVID-19: clinical and mechanistic insights
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2021
The importance of vascular and red blood cell arginase for cardiovascular perturbations in diabetes, obesity and hyperlipidemia.
Swedish Heart-Lung Foundation
1 January 2020 - 31 December 2021

Employments

Affiliated to Research, Department of Medicine, Karolinska Institutet, 2022-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2021
Degree Of Master Of Science In Medicine, Karolinska Institutet, 2019

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