Ali Mahdi

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Articles

Journal article: CARDIOVASCULAR RESEARCH. 2026;122:cvag092.149
Myeloperoxidase delivered by erythrocyte-derived extracellular vesicles promotes oxidative stress and endothelial dysfunction in type 2 diabetes
Collado A; Kontidou E; Santana-Garrido A; Yang J; Mahdi A; Humoud R; Manickam K; Jiao T; Alvarsson M; Pernow J; Zhou Z
Journal article: CARDIOVASCULAR RESEARCH. 2026;122:cvag092.135
Red blood cells and their extracellular vesicles drive vascular endothelial dysfunction in type 2 diabetes through vascular VEGFR2
Jiao T; Collado A; Humoud R; Kontidou E; Santana-Garrido A; Yang J; Mahdi A; Zhou Z
Article: JACC: ADVANCES. 2026;5(5):102702
Post-COVID Postural Orthostatic Tachycardia Syndrome and Inappropriate Sinus Tachycardia: Prevalence, Overlap, and Clinical Characteristics
Juszczyk M; Nawaz S; Mahdi A; Lewinter C; Ricci F; Stahlberg M; Fedorowski A
Journal article: GASTROENTEROLOGY. 2026;170(6):s-1015-s-1016
Sa1624 INCREASED RISK OF ADVERSE ARRHYTHMIA OUTCOMES AFTER ABLATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A NATIONWIDE MATCHED COHORT STUDY
Ebrahimi R; Chen S; Di Vece D; Maremmani M; Mahdi A; Shahim B; Niess JH; Kutz A; Ebrahimi F; Forss A
Journal article: GASTROINTESTINAL ENDOSCOPY. 2026;103(5):s-1015-s-1016
Sa1624 INCREASED RISK OF ADVERSE ARRHYTHMIA OUTCOMES AFTER ABLATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: A NATIONWIDE MATCHED COHORT STUDY
Ebrahimi R; Chen S; Di Vece D; Maremmani M; Mahdi A; Shahim B; Niess JH; Kutz A; Ebrahimi F; Forss A
Article: DIABETES. 2026;75(3):563-570
Long Duration of Type 2 Diabetes Drives Erythrocyte-Induced Vascular Endothelial Dysfunction: A Link to miRNA-210-3p
Kontidou E; Collado A; Humoud R; Manickam K; Tengbom J; Jiao T; Alvarsson M; Yang J; Mellbin L; Mahdi A; Pernow J; Zhou Z
Article: PHYSIOLOGICAL REPORTS. 2026;14(4):e70789
microRNA-210 in red blood cells differentially regulates vascular endothelial function between type 1 and type 2 diabetes
Jiao T; Tengbom J; Kontidou E; Santana-Garrido A; Humoud R; Alvarsson M; Manickam K; Yang J; Mahdi A; Collado A; Pernow J; Zhou Z
Article: ANTIOXIDANTS. 2026;15(1):58
Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia-Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes
Yang J; Tratsiakovich Y; Cao R; Mahdi A; Pironti G; Jiao T; Humoud R; Kontidou E; Tengbom J; Collado A; Zhou Z; Cao Y; Kohler E; Mullick AE; Pernow J
Article: CELL REPORTS MEDICINE. 2025;6(11):102454
Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring
Zhao A; Wei Y; Kontidou E; Mahdi A; Jannig PR; Torstensson S; Jiang H; Larsson A; Collado A; Humoud R; Grunler J; Ersga D; Esen BO; Zheng X; Lu H; Lindgren E; Risal S; Zhao J; Stener-Victorin E; Sorensen HT; Pedersen L; Pernow J; Zhou Z; Carlsson S; Catrina S-B; Deng Q
Journal article: EUROPEAN HEART JOURNAL. 2025;46
Cardiac reverse remodeling induced by cardiac resynchronization therapy results in distinct changes in myocardial work when compared to guideline directed medical therapy
Ljung K; Reistam U; Soderstrom L; Gaylard B; Fischer K; Mahdi A; Stahlberg M
Article: ALIMENTARY PHARMACOLOGY & THERAPEUTICS. 2025;61(12):1904-1912
Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study
Ebrahimi R; Ebrahimi F; Niess JH; Mahdi A; Chen S; Di Vece D; Bian W; Kutz A; Forss A
Article: AMERICAN JOURNAL OF MEDICINE. 2025;138(6):1019-1028
Post-Acute COVID-19 Syndrome: Prevalence of Peripheral Microvascular Endothelial Dysfunction and Associations With NT-ProBNP Dynamics
Stahlberg M; Fischer K; Tahhan M; Zhao A; Fedorowski A; Runold M; Nygren-Bonnier M; Bjornson M; Lund LH; Bruchfeld J; Desta L; Braunschweig F; Mahdi A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;135(10):e180900
Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes
Collado A; Humoud R; Kontidou E; Eldh M; Swaich J; Zhao A; Yang J; Jiao T; Domingo E; Carlestal E; Mahdi A; Tengbom J; Vegvari A; Deng Q; Alvarsson M; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2025;45(Suppl_1):atu0045
Abstract Tu0045: Long Duration of Type 2 Diabetes Promotes Erythrocyte-Induced Endothelial Dysfunction: Role of microRNA-210
Kontidou E; Collado A; Humoud R; Manickam K; Jiao T; Alvarsson M; Yang J; Mahdi A; Pernow J; Zhichao Z
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2025;45(Suppl_1):atu0046a
Abstract Tu0046a: Red Blood Cell-Derived Extracellular Vesicles in Type 2 Diabetes Induce Endothelial Dysfunction Through Transfer of Arginase-1 to the Endothelium
Collado A; Humoud R; Kontidou E; Yang J; Mahdi A; Tengbom J; Zhichao Z; Pernow J
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(2):417-431
miR-210 as a therapeutic target in diabetes-associated endothelial dysfunction
Collado A; Jiao T; Kontidou E; Carvalho LRRA; Chernogubova E; Yang J; Zaccagnini G; Zhao A; Tengbom J; Zheng X; Rethi B; Alvarsson M; Catrina S-B; Mahdi A; Carlstroem M; Martelli F; Pernow J; Zhou Z
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(6):H1431-H1441
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction
Tengbom J; Humoud R; Kontidou E; Jiao T; Yang J; Hedin U; Zhou Z; Jurga J; Collado A; Mahdi A; Pernow J
Journal article: EUROPEAN HEART JOURNAL. 2024;45:ehae666.3685
Increased endothelial cell uptake of erythrocyte-derived extracellular vesicles carrying arginase-1 induces endothelial dysfunction in type 2 diabetes
Collado A; Humoud R; Kontidou E; Swaich J; Yang J; Mahdi A; Tengbom J; Zhou Z; Pernow J
Article: CLINICAL SCIENCE. 2024;138(15):975-985
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase
Tengbom J; Kontidou E; Collado A; Yang J; Alvarsson M; Brinck J; Rossner S; Zhou Z; Pernow J; Mahdi A
Journal article: CARDIOVASCULAR RESEARCH. 2024;120:cvae088.035
Red blood cell-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through a mechanism involving arginase 1
Collado A; Humoud R; Kontidou E; Eldh M; Yang J; Jiao T; Domingo E; Mahdi A; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
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All other publications

Meeting abstract: EUROPEAN HEART JOURNAL. 2025;46
Post-COVID postural orthostatic tachycardia syndrome and inappropriate sinus tachycardia: prevalence, overlap and clinical characteristics
Juszczyk M; Nawaz S; Mahdi A; Lewinter C; Ricci F; Stahlberg M; Fedorowski A
Conference publication: EUROPEAN HEART JOURNAL. 2025;46
Differentiation between arginase 1 and 2 in regulating tolerance to cardiac ischemia-reperfusion via nitric oxide signaling by red blood cells
Yang JN; Tratsiakovich Y; Cao RH; Jiao T; Humoud R; Kontidou E; Tengbom J; Collado A; Mahdi A; Zhou Z; Cao YH; Kohler E; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2025;46
Resynchronization reduces arginase activity in red blood cells of heart failure patients with dyssynchrony
Ljung K; Mahdi A; Reistam U; Fischer K; Olsson A; Stahlberg M
Conference publication: EUROPEAN HEART JOURNAL. 2025;46
Endothelial dysfunction in HFrEF: investigating the role of red blood cells and guideline directed medical therapy
Reistam U; Mahdi A; Ljung K; Fischer K; Olsson A; Stahlberg M
Review: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. 2024;35(3):608-617
Cardiovascular dysautonomia in postacute sequelae of SARS-CoV-2 infection
Stahlberg M; Mahdi A; Johansson M; Fedorowski A; Olshansky B
Meeting abstract: CIRCULATION. 2023;148:a16646
Evidence of Protein Dysregulation in Patients With Post-Acute COVID-19 Syndrome With- and Without Postural Orthostatic Tachycardia Syndrome
Zhao A; Mahdi A; Fredengren E; Fedorowski A; Braunschweig F; Brodin P; Nygren-Bonnier M; Runold M; Bruchfeld J
Letter: CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY. 2023;16(7):413-414
Microvasular Dysfunction and Reduced Cardiac Stress Reactivity in Postural Orthostatic Tachycardia Associated With Postacute COVID-19
Mahdi A; Lodin K; Reistam U; Fedorowski A; Nygren-Bonnier M; Runold M; Bruchfeld J; Desta L; Pernow J; Nickander J; Stahlberg M
Conference publication: GASTROENTEROLOGY. 2023;164(6):S427
PATIENTS WITH MICROSCOPIC COLITIS ARE AT INCREASED RISK OF INCIDENT MAJOR ADVERSE CARDIOVASCULAR EVENTS: A NATIONWIDE HISTOPATHOLOGY MATCHED COHORT STUDY
Forss A; Bergman D; Roelstraete B; Sundstrom J; Mahdi A; Khalili H; Ludvigsson JF
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2917
Red blood cells induce endothelial dysfunction in patients with ST-elevation myocardial infarction and elevated C-reactive protein
Tengbom J; Collado A; Jiao T; Yang J; Zhou Z; Mahdi A; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2022;43:2910
Erythrocytes from patients with ST-elevation myocardial infarction induce cardioprotection via the purinergic P2Y13 receptor and nitric oxide signalling
Jiao T; Mahdi A; Tengbom J; Collado A; Jurga J; Saleh N; Verouhis D; Bohm F; Zhou Z; Yang J; Pernow J
Doctoral thesis: 2021
The red blood cell as a mediator of vascular dysfunction in type 2 diabetes and COVID-19
Mahdi AJ
Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3259
Attenuated cardiac post-ischemic injury and endothelial dysfunction by stimulation of soluble guanylyl cyclase in red blood cells from patients with type 2 diabetes
Jiao T; Zhou Z; Mahdi A; Tengbom J; Tratsiakovich Y; Yang J; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2021;42:3364
Erythrocytes induce vascular dysfunction in COVID-19
Mahdi A; Collado A; Tengbom J; Jiao T; Wodaje T; Yang J; Lundberg JO; Zhou Z; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2021;42:1205
Remote ischemic conditioning fails to protect against ischemia-reperfusion injury in patients with untreated familial hypercholesterolemia
Kovamees O; Mahdi A; Wodaje T; Verouhis D; Brinck J; Pernow J
Editorial: DRUG DISCOVERY TODAY. 2021;26(8):1773-1775
Sunitinib and its effect in the cardiovascular system
Mahdi A; Wernly B; Pernow J; Zhou Z
Review: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2020;301:207-214
Improvement in endothelial function in cardiovascular disease - Is arginase the target?
Mahdi A; Kovamees O; Pernow J
Conference publication: EUROPEAN HEART JOURNAL. 2019;40:3903
Dietary nitrate restores cardiac ischemic tolerance in type 2 diabetic mice and protects against ischemia-reperfusion injury via soluble guanylate cyclase in red blood cells
Yang JN; Jiao T; Tratsiakovich Y; Mahdi A; Zhou Z; Lundberg JO; Pernow J
Review: CARDIOVASCULAR RESEARCH. 2019;115(11):1596-1605
Red blood cell dysfunction: a new player in cardiovascular disease
Pernow J; Mahdi A; Yang J; Zhou Z
Conference publication: EUROPEAN HEART JOURNAL. 2018;39:522-523
Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose lowering therapy
Mahdi A; Kovamees O; Von Heijne M; Alvarsson M; Pernow J
Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S42
Vascular endothelial growth factor receptor 2 inhibition improves endothelial function in type 2 diabetic rats: a link to purinergic signalling?
Mahdi A; Tratsiakovich Y; Yang J; Ostenson C-G; Danser JAH; Pernow J; Zhou Z
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Grants

Coronary microvascular dysfunction: Identification of disease mechanisms and novel therapeutic targets
Svenska Läkaresällskapet (SLS Projektanslag)
18 April 2025
Microvascular Dysfunction: Clinical Outcomes, Identification of Disease Mechanisms and Novel Therapeutic Targets
Heart and Lung Foundation
1 January 2025 - 1 January 2026
Is post-COVID an autoimmune disease? A comprehensive translational study aimed at rapid implementation of treatment [Translated from Swedish by AI.]
Region Stockholm (ALF Medicine) [Translated from Swedish by AI.]
20 December 2023
Coronary Microvascular Dysfunction: Identification of Disease Mechanisms and Novel Therapeutic Targets
Region Stockholm (Clinical postdocs)
21 June 2023
The importance of erythrocyte dysfunction for the development of cardiovascular disease in type 2 diabetes and as a target for new treatments. [Translated from Swedish by AI.]
Region Stockholm (ALF Medicine) [Translated from Swedish by AI.]
25 January 2023
The importance of microvascular endothelial dysfunction for acute and long-term complications of COVID-19: clinical and mechanistic insights
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2021
The importance of vascular and red blood cell arginase for cardiovascular perturbations in diabetes, obesity and hyperlipidemia.
Swedish Heart-Lung Foundation
1 January 2020 - 31 December 2021
Strategic Research Program (SRP) in Diabetes

Employments

Affiliated to Research, Department of Medicine, Karolinska Institutet, 2025-2028

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2021
Degree Of Master Of Science In Medicine, Karolinska Institutet, 2019

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