Alexander Espinosa

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: EMBO REPORTS. 2023;24(1):e54944
The bromodomain protein TRIM28 controls the balance between growth and invasiveness in melanoma
Nyberg WA; Velasquez-Pulgarin DA; He T; Sjostrand M; Pelle L; Covacu R; Espinosa A
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161
Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function
Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: BIOMOLECULES. 2022;12(6):779
Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1
Qu H; Heinback R; Salo H; Ewing E; Espinosa A; Aulin C; Erlandsson Harris H
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173
SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development
Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
Article: IMMUNOLOGY. 2020;159(3):335-343
TRIM21 controls Toll-like receptor 2 responses in bone-marrow-derived macrophages
Sjoestrand M; Carow B; Nyberg WA; Covacu R; Rottenberg ME; Espinosa A
Article: RMD OPEN. 2020;6(1):e000989
Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
Hedlund M; Thorlacius GE; Ivanchenko M; Ottosson V; Kyriakidis N; Lagnefeldt L; Tingstrom J; Sirsjo A; Bengtsson AA; Aronsson E; Gemzell-Danielsson K; Ronnblom L; Bergman G; Espinosa A; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(30):11404-11419
E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2
Anandapadamanaban M; Kyriakidis NC; Csizmok V; Wallenhammar A; Espinosa AC; Ahlner A; Round AR; Trewhella J; Moche M; Wahren-Herlenius M; Sunnerhagen M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(2):313-322
miR-31 regulates energy metabolism and is suppressed in Tcells from patients with Sjogren's syndrome
Johansson A; Nyberg WA; Sjostrand M; Moruzzi N; Bergman P; Khademi M; Andersson M; Piehl F; Berggren P-O; Covacu R; Jagodic M; Espinosa A
Article: NATURE COMMUNICATIONS. 2018;9(1):4845
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;193(2):167-177
The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages
Mentlein L; Thorlacius GE; Meneghel L; Aqrawi LA; Sepulveda JIR; Grunewald J; Espinosa A; Wahren-Herlenius M
Article: EXPERIMENTAL DERMATOLOGY. 2017;26(8):713-720
TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model
Vinter H; Langkilde A; Ottosson V; Espinosa A; Wahren-Herlenius M; Raaby L; Johansen C; Iversen L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2016;473(4):789-794
Imiquimod induces ER stress and Ca²⁺ influx independently of TLR7 and TLR8
Nyberg WA; Espinosa A
Article: JOURNAL OF IMMUNOLOGY. 2016;196(1):91-96
The Expression of BAFF Is Controlled by IRF Transcription Factors
Sjostrand M; Johansson A; Aqrawi L; Olsson T; Wahren-Herlenius M; Espinosa A
Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3753-3763
Expression of the Immune Regulator Tripartite-Motif 21 Is Controlled by IFN Regulatory Factors
Sjostrand M; Ambrosi A; Brauner S; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(5):1601-1609
Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus
Smith S; Gabhann JN; Higgs R; Stacey K; Wahren-Herlenius M; Espinosa A; Totaro MG; Sica A; Ball E; Bell A; Johnston J; Browne P; O'Neill L; Kearns G; Jefferies CA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(42):36478-36491
Anti-Ro52 Autoantibodies from Patients with Sjogren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface
Espinosa A; Hennig J; Ambrosi A; Anandapadmanaban M; Abelius MS; Sheng Y; Nyberg F; Arrowsmith CH; Sunnerhagen M; Wahren-Herlenius M
Article: MULTIPLE SCLEROSIS JOURNAL. 2010;16(9):1056-1065
Interleukin 18 Receptor 1 expression distinguishes patients with multiple sclerosis
Gillett A; Hedreul MT; Khademi M; Espinosa A; Beyeen AD; Jagodic M; Kockum I; Harris RA; Olsson T
Article: PLOS ONE. 2010;5(7):e11776
Self Protection from Anti-Viral Responses-Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors
Higgs R; Lazzari E; Wynne C; Gabhann JN; Espinosa A; Wahren-Herlenius M; Jefferies CA
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2009;206(8):1661-1671
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway
Espinosa A; Dardalhon V; Brauner S; Ambrosi A; Higgs R; Quintana FJ; Sjostrand M; Eloranta M-L; Gabhann JN; Winqvist O; Sundelin B; Jefferies CA; Rozell B; Kuchroo VK; Wahren-Herlenius M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(8):2000-2010
High Ro52 Expression in Spontaneous and UV-Induced Cutaneous Inflammation
Oke V; Vassilaki I; Espinosa A; Strandberg L; Kuchroo VK; Nyberg F; Wahren-Herlenius M
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(20):3605-3613
The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide
Espinosa A; Oke V; Elfving A; Nyberg F; Covacu R; Wahren-Herlenius M
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2008;28(3):220-231
Interferon-α induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies
Strandberg L; Arnbrosi A; Espinosa A; Ottosson L; Eloranta M-L; Zhou W; Elfving A; Greenfield E; Kuchroo VK; Wahren-Herlenius M
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):6277-6285
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death
Espinosa A; Zhou W; Ek M; Hedlund M; Brauner S; Popovic K; Horvath L; Wallerskog T; Oukka M; Nyberg F; Kuchroo VK; Wahren-Herlenius M
Article: MOLECULAR IMMUNOLOGY. 2006;43(6):588-598
Structural, functional and immunologic characterization of folded subdomains in the Ro52, protein targeted in Sjogren's syndrome
Ottosson L; Hennig J; Espinosa A; Brauner S; Wahren-Herlenius M; Sunnerhagen M
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3639-3645
Increased-expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
Popovic K; Ek M; Espinosa A; Padyukov L; Harris HE; Wahren-Herlenius M; Nyberg F
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Alla övriga publikationer

Preprint: BIORXIV. 2023;BIORXIV
Light induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo.
Pulgarin DV; Pelo N; Ferrandiz L; Trselic T; Nyberg WA; Bowlin G; Espinosa A
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(12):1840-1842
Clinical associations and expression pattern of the autoimmunity susceptibility factor DIORA-1 in patients with primary Sjogren's syndrome
Aqrawi LA; Mentlein L; Meneghel L; Bjork A; Thorlacius GE; Ivanchenko M; Sepulveda JIR; Skarstein K; Kvarnstrom M; Brauner S; Espinosa A; Wahren-Herlenius M
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(9):2274-2284
IL-17: A new actor in IFN-driven systemic autoimmune diseases
Ambrosi A; Espinosa A; Wahren-Herlenius M
Review: IMMUNOLOGY LETTERS. 2011;141(1):1-9
The complexity of Sjogren's syndrome: Novel aspects on pathogenesis
Jonsson R; Vogelsang P; Volchenkov R; Espinosa A; Wahren-Herlenius M; Appel S
Letter: JOURNAL OF IMMUNOLOGY. 2009;183(12):7620-7621
Comment on "Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-κB-Dependent Cytokine Expression in Fibroblasts Response
Espinosa A; Brauner S; Ambrosi A; Kuchroo V; Wahren-Herlenius M
Thesis / dissertation: 2008
A study on the E3 ligase TRIM21/Ro52
Espinosa, Alexander
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S24
Anti-Ro/SSA autoantibodies specific for the RING-domain of ro52 inhibit E3 ligase activity and polyubiquitination
Espinosa A; Hennig J; Ambrosi A; Nyberg F; Sunnerhaqen M; Wahren-Herlenius M
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S25
The Sjogren's syndrome associated autoantigen Ro52 is a ring-dependent E3 ligase that regulates cell death.
Espinosa A; Zhou W; Oukka M; Kuchroo V; Wahren-Herlenius M

Anställningar

Senior Forskningsspecialist, Medicin, Solna, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Immunologi, Karolinska Institutet, 2020
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2008

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Anställningar

Examina och utbildning

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