Alan K Fotoohi
Anknuten till Forskning
E-postadress: alan.fotoohi@ki.se
Besöksadress: Avd.För klinisk Farmakologi C1:68, Karolinska Universitetssjukhuset, 14186 Stockholm
Postadress: H5 Laboratoriemedicin, H5 Klin Farmakologi, 141 52 Huddinge
Forskningsbeskrivning
- *Publications*
- Introducing a simple and cost-effective RT-PCR protocol for detection of
DPYD*2A polymorphism: the first study in Kurdish population. Salmani M,
Ghaderi B, *Fotoohi A*, Omid-Shafa'at R, Vahabzadeh Z, Fotouhi O, Abdi M.
Cancer Chemother Pharmacol. 2022 Nov - 90(5):389-397. doi:
10.1007/s00280-022-04472-w. Epub 2022 Sep 9. PMID: 36083300
https://pubmed.ncbi.nlm.nih.gov/36083300/# [1]
/- CYP2D6/ Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites
in Ethiopian Breast Cancer Patients. Ahmed JH, Makonnen E, *Fotoohi A*,
Aseffa A, Howe R, Aklillu E.
Cancers (Basel). 2019 Sep 12 - 11(9):1353. doi:
10.3390/cancers11091353.PMID: 31547390
https://pubmed.ncbi.nlm.nih.gov/31547390/ [2]
- Vitamin D Status and Association of /VDR/ Genetic Polymorphism to Risk
of Breast Cancer in Ethiopia. [3]
Ahmed JH, Makonnen E, *Fotoohi A*, Yimer G, Seifu D, Assefa M, Tigeneh W,
Aseffa A, Howe R, Aklillu E.
Nutrients. 2019 Jan 29 - 11(2):289. doi: 10.3390/nu11020289.PMID: 30699973
https://pubmed.ncbi.nlm.nih.gov/30699973/ [4]
- CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic
Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer
Patients.
Ahmed JH, Makonnen E, Yimer G, Seifu D, Bekele A, Assefa M, Aseffa A, Howe
R, *Fotoohi A*, Hassan M, Aklillu E.Front Pharmacol. 2019 May 14 - 10:481.
doi: 10.3389/fphar.2019.00481. eCollection
2019.PMID: 31139078https://pubmed.ncbi.nlm.nih.gov/31139078/ [5]
- *Fotoohi AK*, Karim H, Lafolie P, Pohanka A, Östervall J, Hatschek T,
Vitols S. Pronounced Interindividual But Not Intraindividual Variation in
Tamoxifen and Metabolite Levels in Plasma During Adjuvant Treatment of Women
With Early Breast Cancer. Ther Drug Monit. 2016 Apr - 38(2):239-45. doi:
10.1097/FTD.0000000000000257. PubMed PMID: 26485084.
http://www.ncbi.nlm.nih.gov/pubmed/?term=26485084 [6]
- Karim H, Appell ML, *Fotoohi A*. Comparison of three methods for measuring
thiopurine methyltransferase activity in red blood cells and human leukemia
cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 15 - 939:80-5.
doi: 10.1016/j.jchromb.2013.08.036. Epub 2013 Sep 14. PubMed PMID: 24113235.
http://www.ncbi.nlm.nih.gov/pubmed/?term=24113235 [7]
- Karim H, Ghalali A, Lafolie P, Vitols S, *Fotoohi AK*. Differential role
of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine
and 6-thioguanine on human leukemia cells. Biochem Biophys Res Commun. 2013
Jul26 - 437(2):280-6. doi: 10.1016/j.bbrc.2013.06.067. Epub 2013 Jun 27. PubMed
PMID: 23811272.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23811272 [8]
- Karim H, Bogason A, Bhuiyan H, *Fotoohi AK*, Lafolie P, Vitols S.
Comparison of uptake mechanisms for anthracyclines in human leukemic cells.
Curr Drug Deliv. 2013 Aug - 10(4):404-12. PubMed PMID: 23062181.
http://www.ncbi.nlm.nih.gov/pubmed/?term=23062181 [9]
- Karim H, Hashemi J, Larsson C, Moshfegh A, *Fotoohi AK*, Albertioni F. The
pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and
6-Thioguanine-resistant human leukemia cells. Biochem Biophys Res Commun.
2011 Jul 22 - 411(1):156-61. doi: 10.1016/j.bbrc.2011.06.120. Epub 2011 Jun 23.
PubMed PMID: 21723252.
http://www.ncbi.nlm.nih.gov/pubmed/?term=21723252 [10]
-* Fotoohi AK*, Melin AS. Painful pelvic joints induced by a
levonorgestrel-releasing intrauterine system. J Obstet Gynaecol Res. 2010
Oct - 36(5):1142-3. PubMed PMID: 21058450.
http://www.ncbi.nlm.nih.gov/pubmed/?term=21058450 [11]
-* Fotoohi AK*, Coulthard SA, Albertioni F. Thiopurines: factors influencing
toxicity and response. Biochem Pharmacol. 2010 May 1 - 79(9):1211-20.
doi:10.1016/j.bcp.2010.01.006. Epub 2010 Jan 21. PubMed PMID: 20096268.
http://www.ncbi.nlm.nih.gov/pubmed/?term=20096268 [12]
- *Fotoohi AK*, Assaraf YG, Moshfegh A, Hashemi J, Jansen G, Peters GJ,
Larsson C, Albertioni F. Gene expression profiling of leukemia T-cells
resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that
preserve intracellular levels of folate and nucleotide biosynthesis. Biochem
Pharmacol. 2009 Apr 15 - 77(8):1410-7. doi: 10.1016/j.bcp.2008.12.026. Epub
2009 Jan 19. PubMed PMID:
19426680.http://www.ncbi.nlm.nih.gov/pubmed/?term=19426680 [13]
- *Fotoohi AK*, Albertioni F. Mechanisms of antifolate resistance and
methotrexate efficacy in leukemia cells. Leuk Lymphoma. 2008
Mar - 49(3):410-26. doi: 10.1080/10428190701824569. Review. PubMed PMID:
18297517.http://www.ncbi.nlm.nih.gov/pubmed/?term=18297517 [14]
-* Fotoohi AK*, Lindqvist M, Peterson C, Albertioni F. Impaired transport as
a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia
cells. Nucleosides Nucleotides Nucleic Acids. 2006 - 25(9-11):1039-44. PubMed
PMID: 17065061.
http://www.ncbi.nlm.nih.gov/pubmed/?term=17065061 [15]
-* Fotoohi AK*, Wrabel A, Moshfegh A, Peterson C, Albertioni F. Molecular
mechanisms underlying the enhanced sensitivity of thiopurine-resistant
T-lymphoblastic cell lines to methyl mercaptopurineriboside. Biochem
Pharmacol. 2006 Sep 28 - 72(7):816-23. Epub 2006 Jul 20. PubMed PMID: 16859645.
http://www.ncbi.nlm.nih.gov/pubmed/?term=16859645 [16]
-* Fotoohi AK*, Lindqvist M, Peterson C, Albertioni F. Involvement of the
concentrative nucleoside transporter 3 and equilibrative nucleoside
transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.
Biochem Biophys Res Commun. 2006 Apr 28 - 343(1):208-15. Epub 2006 Mar 3.
PubMed PMID: 16530731.
http://www.ncbi.nlm.nih.gov/pubmed/?term=16530731 [17]
-* Fotoohi K*, Skärby T, Söderhäll S, Peterson C, Albertioni F.
Interference of 7-hydroxymethotrexate with the determination of methotrexate
in plasma samples from children with acute lymphoblastic leukemia employing
routine clinical assays. J Chromatogr B Analyt Technol Biomed Life Sci. 2005
Mar 25 - 817(2):139-44. PubMed PMID: 15686977.
http://www.ncbi.nlm.nih.gov/pubmed/?term=15686977 [18]
- *Fotoohi K*, Jansen G, Assaraf YG, Rothem L, Stark M, Kathmann I,
Gregorczyk J, Peters GJ, Albertioni F. Disparate mechanisms of antifolate
resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate
in leukemia cells: implications for efficacy of methotrexate therapy. Blood.
2004 Dec 15 - 104(13):4194-201. Epub 2004 Aug 12. PubMed PMID: 15308564.
http://www.ncbi.nlm.nih.gov/pubmed/?term=15308564 [19]
*- Alan K Fotoohi*. Pharmacological and molecular investigations on the
mechanisms underlying resistance of human cells to the antimetabolites
methotrexate, 6-mercaptopurine and 6-thioguanine. *Doctoral thesis.* From
the Departmnet of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska
Indtitutet at Karolinska University Hospital, Solna, Stockholm, Sweden.
https://openarchive.ki.se/xmlui/bitstream/handle/10616/38962/thesis.pdf?sequence=1& - isAllowed=y
[20]
- RNA interference targeting thiopurine methyl transferase gene alter the
effect of the 6-mercaptopurine in human leukaemia cells. Freidoun
Albertioni, *Alan K. Fotoohi*, Jamileh Hashemi, Elham Hedayati and Catharina
Larsson. American Society of Haematology 52nd annual meeting, 2011, USA.
Abstract
[1] https://pubmed.ncbi.nlm.nih.gov/36083300/
[2] https://pubmed.ncbi.nlm.nih.gov/31547390/
[3] https://pubmed.ncbi.nlm.nih.gov/30699973/
[4] https://pubmed.ncbi.nlm.nih.gov/30699973/
[5] https://pubmed.ncbi.nlm.nih.gov/31139078/
[6] http://www.ncbi.nlm.nih.gov/pubmed/?term=26485084
[7] http://www.ncbi.nlm.nih.gov/pubmed/?term=24113235
[8] http://www.ncbi.nlm.nih.gov/pubmed/?term=23811272
[9] http://www.ncbi.nlm.nih.gov/pubmed/?term=23062181
[10] http://www.ncbi.nlm.nih.gov/pubmed/?term=21723252
[11] http://www.ncbi.nlm.nih.gov/pubmed/?term=21058450
[12] http://www.ncbi.nlm.nih.gov/pubmed/?term=20096268
[13] http://www.ncbi.nlm.nih.gov/pubmed/?term=19426680
[14] http://www.ncbi.nlm.nih.gov/pubmed/?term=18297517
[15] http://www.ncbi.nlm.nih.gov/pubmed/?term=17065061
[16] http://www.ncbi.nlm.nih.gov/pubmed/?term=16859645
[17] http://www.ncbi.nlm.nih.gov/pubmed/?term=16530731
[18] http://www.ncbi.nlm.nih.gov/pubmed/?term=15686977
[19] http://www.ncbi.nlm.nih.gov/pubmed/?term=15308564
[20] https://openarchive.ki.se/xmlui/bitstream/handle/10616/38962/thesis.pdf?sequence=1& - amp
- isAllowed=y
Artiklar
- Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2022;90(5):389-397
- Article: FRONTIERS IN PHARMACOLOGY. 2020;11:406
- Article: CANCERS. 2019;11(9):E1353-1353
- Article: NUTRIENTS. 2019;11(2):E289-289
- Article: FRONTIERS IN PHARMACOLOGY. 2019;10:481
- Article: THERAPEUTIC DRUG MONITORING. 2016;38(2):239-245
- Article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2013;939:80-85
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;437(2):280-286
- Article: CURRENT DRUG DELIVERY. 2013;10(4):404-412
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):156-161
- Article: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH. 2010;36(5):1142-1143
- Article: BIOCHEMICAL PHARMACOLOGY. 2010;79(9):1211-1220
- Article: BIOCHEMICAL PHARMACOLOGY. 2009;77(8):1410-1417
- Article: BIOCHEMICAL PHARMACOLOGY. 2006;72(7):816-823
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;343(1):208-215
- Article: JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2005;817(2):139-144
Alla övriga publikationer
- Review: EUROPEAN JOURNAL OF CANCER. 2021;157:428-440
- Review: LEUKEMIA AND LYMPHOMA. 2008;49(3):410-426
- Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2006;25(9-11):1039-1044
Anställningar
- Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2023-2026
Examina och utbildning
- MEDICINE DOKTORSEXAMEN, Institutionen för onkologi-patologi, Karolinska Institutet, 2007