Alan K Fotoohi

Alan K Fotoohi

Anknuten till Forskning
Besöksadress: Avd.För klinisk Farmakologi C1:68, Karolinska Universitetssjukhuset, 14186 Stockholm
Postadress: H5 Laboratoriemedicin, H5 Klin Farmakologi, 141 52 Huddinge


  • *Publications*
    - Introducing a simple and cost-effective RT-PCR protocol for detection of
    DPYD*2A polymorphism: the first study in Kurdish population. Salmani M,
    Ghaderi B, *Fotoohi A*, Omid-Shafa'at R, Vahabzadeh Z, Fotouhi O, Abdi M.
    Cancer Chemother Pharmacol. 2022 Nov
  • 90(5):389-397. doi:
    10.1007/s00280-022-04472-w. Epub 2022 Sep 9. PMID: 36083300 [1]
    /- CYP2D6/ Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites
    in Ethiopian Breast Cancer Patients. Ahmed JH, Makonnen E, *Fotoohi A*,
    Aseffa A, Howe R, Aklillu E.
    Cancers (Basel). 2019 Sep 12
  • 11(9):1353. doi:
    10.3390/cancers11091353.PMID: 31547390 [2]
    - Vitamin D Status and Association of /VDR/ Genetic Polymorphism to Risk
    of Breast Cancer in Ethiopia. [3]
    Ahmed JH, Makonnen E, *Fotoohi A*, Yimer G, Seifu D, Assefa M, Tigeneh W,
    Aseffa A, Howe R, Aklillu E.
    Nutrients. 2019 Jan 29
  • 11(2):289. doi: 10.3390/nu11020289.PMID: 30699973 [4]
    - CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic
    Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer
    Ahmed JH, Makonnen E, Yimer G, Seifu D, Bekele A, Assefa M, Aseffa A, Howe
    R, *Fotoohi A*, Hassan M, Aklillu E.Front Pharmacol. 2019 May 14
  • 10:481.
    doi: 10.3389/fphar.2019.00481. eCollection
    2019.PMID: 31139078 [5]
    - *Fotoohi AK*, Karim H, Lafolie P, Pohanka A, Östervall J, Hatschek T,
    Vitols S. Pronounced Interindividual But Not Intraindividual Variation in
    Tamoxifen and Metabolite Levels in Plasma During Adjuvant Treatment of Women
    With Early Breast Cancer. Ther Drug Monit. 2016 Apr
  • 38(2):239-45. doi:
    10.1097/FTD.0000000000000257. PubMed PMID: 26485084. [6]
    - Karim H, Appell ML, *Fotoohi A*. Comparison of three methods for measuring
    thiopurine methyltransferase activity in red blood cells and human leukemia
    cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 15
  • 939:80-5.
    doi: 10.1016/j.jchromb.2013.08.036. Epub 2013 Sep 14. PubMed PMID: 24113235. [7]
    - Karim H, Ghalali A, Lafolie P, Vitols S, *Fotoohi AK*. Differential role
    of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine
    and 6-thioguanine on human leukemia cells. Biochem Biophys Res Commun. 2013
  • 437(2):280-6. doi: 10.1016/j.bbrc.2013.06.067. Epub 2013 Jun 27. PubMed
    PMID: 23811272. [8]
    - Karim H, Bogason A, Bhuiyan H, *Fotoohi AK*, Lafolie P, Vitols S.
    Comparison of uptake mechanisms for anthracyclines in human leukemic cells.
    Curr Drug Deliv. 2013 Aug
  • 10(4):404-12. PubMed PMID: 23062181. [9]
    - Karim H, Hashemi J, Larsson C, Moshfegh A, *Fotoohi AK*, Albertioni F. The
    pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and
    6-Thioguanine-resistant human leukemia cells. Biochem Biophys Res Commun.
    2011 Jul 22
  • 411(1):156-61. doi: 10.1016/j.bbrc.2011.06.120. Epub 2011 Jun 23.
    PubMed PMID: 21723252. [10]
    -* Fotoohi AK*, Melin AS. Painful pelvic joints induced by a
    levonorgestrel-releasing intrauterine system. J Obstet Gynaecol Res. 2010
  • 36(5):1142-3. PubMed PMID: 21058450. [11]
    -* Fotoohi AK*, Coulthard SA, Albertioni F. Thiopurines: factors influencing
    toxicity and response. Biochem Pharmacol. 2010 May 1
  • 79(9):1211-20.
    doi:10.1016/j.bcp.2010.01.006. Epub 2010 Jan 21. PubMed PMID: 20096268. [12]
    - *Fotoohi AK*, Assaraf YG, Moshfegh A, Hashemi J, Jansen G, Peters GJ,
    Larsson C, Albertioni F. Gene expression profiling of leukemia T-cells
    resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that
    preserve intracellular levels of folate and nucleotide biosynthesis. Biochem
    Pharmacol. 2009 Apr 15
  • 77(8):1410-7. doi: 10.1016/j.bcp.2008.12.026. Epub
    2009 Jan 19. PubMed PMID:
    19426680. [13]
    - *Fotoohi AK*, Albertioni F. Mechanisms of antifolate resistance and
    methotrexate efficacy in leukemia cells. Leuk Lymphoma. 2008
  • 49(3):410-26. doi: 10.1080/10428190701824569. Review. PubMed PMID:
    18297517. [14]
    -* Fotoohi AK*, Lindqvist M, Peterson C, Albertioni F. Impaired transport as
    a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia
    cells. Nucleosides Nucleotides Nucleic Acids. 2006
  • 25(9-11):1039-44. PubMed
    PMID: 17065061. [15]
    -* Fotoohi AK*, Wrabel A, Moshfegh A, Peterson C, Albertioni F. Molecular
    mechanisms underlying the enhanced sensitivity of thiopurine-resistant
    T-lymphoblastic cell lines to methyl mercaptopurineriboside. Biochem
    Pharmacol. 2006 Sep 28
  • 72(7):816-23. Epub 2006 Jul 20. PubMed PMID: 16859645. [16]
    -* Fotoohi AK*, Lindqvist M, Peterson C, Albertioni F. Involvement of the
    concentrative nucleoside transporter 3 and equilibrative nucleoside
    transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines.
    Biochem Biophys Res Commun. 2006 Apr 28
  • 343(1):208-15. Epub 2006 Mar 3.
    PubMed PMID: 16530731. [17]
    -* Fotoohi K*, Skärby T, Söderhäll S, Peterson C, Albertioni F.
    Interference of 7-hydroxymethotrexate with the determination of methotrexate
    in plasma samples from children with acute lymphoblastic leukemia employing
    routine clinical assays. J Chromatogr B Analyt Technol Biomed Life Sci. 2005
    Mar 25
  • 817(2):139-44. PubMed PMID: 15686977. [18]
    - *Fotoohi K*, Jansen G, Assaraf YG, Rothem L, Stark M, Kathmann I,
    Gregorczyk J, Peters GJ, Albertioni F. Disparate mechanisms of antifolate
    resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate
    in leukemia cells: implications for efficacy of methotrexate therapy. Blood.
    2004 Dec 15
  • 104(13):4194-201. Epub 2004 Aug 12. PubMed PMID: 15308564. [19]
    *- Alan K Fotoohi*. Pharmacological and molecular investigations on the
    mechanisms underlying resistance of human cells to the antimetabolites
    methotrexate, 6-mercaptopurine and 6-thioguanine. *Doctoral thesis.* From
    the Departmnet of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska
    Indtitutet at Karolinska University Hospital, Solna, Stockholm, Sweden.
  • isAllowed=y
    - RNA interference targeting thiopurine methyl transferase gene alter the
    effect of the 6-mercaptopurine in human leukaemia cells. Freidoun
    Albertioni, *Alan K. Fotoohi*, Jamileh Hashemi, Elham Hedayati and Catharina
    Larsson. American Society of Haematology 52nd annual meeting, 2011, USA.
  • amp
  • isAllowed=y


Alla övriga publikationer


  • Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2023-2026

Examina och utbildning

  • MEDICINE DOKTORSEXAMEN, Institutionen för onkologi-patologi, Karolinska Institutet, 2007

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