Alan K Fotoohi

Publications
CV
Public outreach and news

Articles

Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2022;90(5):389-397
Introducing a simple and cost-effective RT-PCR protocol for detection of DPYD*2A polymorphism: the first study in Kurdish population
Salmani M; Ghaderi B; Fotoohi A; Omid-Shafa'at R; Vahabzadeh Z; Fotouhi O; Abdi M
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:406
Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients
Ahmed JH; Makonnen E; Bisaso RK; Mukonzo JK; Fotoohi A; Aseffa A; Howe R; Hassan M; Aklillu E
Article: CANCERS. 2019;11(9):E1353-1353
CYP2D6 Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients
Ahmed JH; Makonnen E; Fotoohi A; Aseffa A; Howe R; Aklillu E
Article: NUTRIENTS. 2019;11(2):E289-289
Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia
Ahmed JH; Makonnen E; Fotoohi A; Yimer G; Seifu D; Assefa M; Tigeneh W; Aseffa A; Howe R; Aklillu E
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:481
CYP2J2*7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients
Ahmed JH; Makonnen E; Yimer G; Seifu D; Bekele A; Assefa M; Aseffa A; Howes R; Fotoohi A; Hassan M; Aklillu E
Article: THERAPEUTIC DRUG MONITORING. 2016;38(2):239-245
Pronounced Interindividual But Not Intraindividual Variation in Tamoxifen and Metabolite Levels in Plasma During Adjuvant Treatment of Women With Early Breast Cancer
Fotoohi AK; Karim H; Lafolie P; Pohanka A; Ostervall J; Hatschek T; Vitols S
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2013;939:80-85
Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells
Karim H; Appell ML; Fotoohi A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;437(2):280-286
Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells
Karim H; Ghalali A; Lafolie P; Vitols S; Fotoohi AK
Article: CURRENT DRUG DELIVERY. 2013;10(4):404-412
Comparison of Uptake Mechanisms for Anthracyclines in Human Leukemic Cells
Karim H; Bogason A; Bhuiyan H; Fotoohi AK; Lafolie P; Vitols S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):156-161
The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells
Karim H; Hashemi J; Larsson C; Moshfegh A; Fotoohi AK; Albertioni F
Article: JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH. 2010;36(5):1142-1143
Painful pelvic joints induced by a levonorgestrel-releasing intrauterine system
Fotoohi AK; Melin A-S
Article: BIOCHEMICAL PHARMACOLOGY. 2010;79(9):1211-1220
Thiopurines: Factors influencing toxicity and response
Fotoohi AK; Coulthard SA; Albertioni F
Article: BIOCHEMICAL PHARMACOLOGY. 2009;77(8):1410-1417
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis
Fotoohi AK; Assaraf YG; Moshfegh A; Hashemi J; Jansen G; Peters GJ; Larsson C; Albertioni F
Article: BIOCHEMICAL PHARMACOLOGY. 2006;72(7):816-823
Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside
Fotoohi AK; Wrabel A; Moshfegh A; Peterson C; Albertioni F
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;343(1):208-215
Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines
Fotoohi AK; Lindqvist M; Peterson C; Albertioni F
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2005;817(2):139-144
Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays
Fotoohi K; Skärby T; Söderhäll S; Peterson C; Albertioni F
Article: BLOOD. 2004;104(13):4194-4201
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy
Fotoohi K; Jansen G; Assaraf YG; Rothem L; Stark M; Kathmann I; Gregorczyk J; Peters GJ; Albertioni F

All other publications

Review: EUROPEAN JOURNAL OF CANCER. 2021;157:428-440
Therapeutic drug monitoring in oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology consensus guidelines for imatinib therapy
Clarke WA; Chatelut E; Fotoohi AK; Larson RA; Martin JH; Mathijssen RHJ; Salamone SJ
Review: LEUKEMIA & LYMPHOMA. 2008;49(3):410-426
Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells
Fotoohi AK; Albertioni F
Doctoral thesis: 2007
Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine
Fotoohi AK
Published conference paper: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2006;25(9-11):1039-1044
Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells
Fotoohi AK; Lindqvist M; Peterson C; Albertioni F
Meeting abstract: BLOOD. 2004;104(11):176B
Disparate mechanisms of Antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: Implications for efficacy of methotrexate therapy.
Albertioni F; Jansen G; Fotoohi K; Assaraf YG; Rothem L; Stark M; Kathmann L; Gregorczyk J; Peters GJ

Employments

Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2023-2026

Degrees and Education

Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2007

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