Funktionell Precisionsmedicin – Brinton Seashore-Ludlows team

Publikationer

Alla gruppmedlemmars publikationer

• Article: NATURE COMMUNICATIONS. 2026;17(1):10790

  High-content morphological profiling by Cell Painting in 3D spheroids

  Ringers C; Holmberg D; Larsson A; Jung B; Jarvius M; Luchniak A; Rosen D; Johansson M; Georgiev P; Seashore-Ludlow B; Visnes T; Flobak A; Carreras-Puigvert J; Spjuth O
• Article: PEDIATRIC BLOOD & CANCER. 2026;:e70696

  Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient-Derived Tumor Organoids

  Wierbilowicz K; Park SWS; Los A; Liu E; Struyf N; Erkers T; Lehmann S; Molenaar JJ; Stenman J; Kallioniemi O; Ostling P; Seashore-Ludlow B; Karlsson K
• Article: ISCIENCE. 2026;29(8):116673

  A host-centric morphological profiling approach to identify repurposed antiviral drugs

  Asp E; Rietdijk J; Tampere M; Axelsson H; Njenda D; Potdar S; Kalman A; Georgieva P; Lapins M; Ballante F; Soler A; de Kort M; Aittokallio T; Zaliani A; Kuzikov M; Gribbon P; Lo D; Carreras-Puigvert J; Seashore-Ludlow B; Spjuth O; Stling P
• Article: NPJ PRECISION ONCOLOGY. 2026;10(1):301

  Functional profiling of ovarian cancer models reveals Bcl-xL/NOTCH targeting to overcome resistance

  Gudoityte G; Berkovska O; Orre LM; Moussaud-Lamodiere E; Bergstrom R; Lindberg J; Haraldsson M; Nafeh SB; Louhaur M; Kallioniemi O; Fernebro J; Joneborg U; Seashore-Ludlow B
• Article: BIOMEDICINE & PHARMACOTHERAPY. 2026;200:119575

  Standardized workflow enables reproducibility of drug synergism detection: Results from a multi-center in vitro ring test on complex drug combinations in pancreatic cancer models.

  Barile V; Kuzikov M; Cui W; Ianevski A; Iannelli F; Roca MS; Reinshagen J; Axelsson H; Leone A; Jenmalm Jensen A; Aittokallio T; Gribbon P; Seashore-Ludlow B; Budillon A
• Article: EBIOMEDICINE. 2026;129:106330

  Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis

  Wen X; Qu H; Benedyk-Machaczka M; Chen D; Sundberg E; Melen E; Altman M; Aulin C; Harris HE
• Article: STAR PROTOCOLS. 2026;7(2):104480

  Protocol for culture, drug treatment, and dissociation of patient-derived 3D ovarian cancer microspheroids for flow cytometry

  Haffa M; Juhani K; Gudoityte G; Otvos RH-G; Wallin E; Kallioniemi O-P; Fernebro J; Joneborg U; Seashore-Ludlow B
• Preprint: BIORXIV. 2026

  Human-supervised Agentic AI for Hypothesis Generation and Experimental Assistance in Drug Repurposing

  Huynh DL; Asp E; Ballante F; Puigvert JC; DeGrave A; Karki R; Nader K; Östling P; Pokharel B; Rietdijk J; Schlotawa L; Schmidt L; Seal S; Seashore-Ludlow B; Aittokallio T; Spjuth O
• Conference publication: 2026

  Establishing the Remedi4All harmonized repurposing set as a community-shared, high-quality drug repurposing resource

  Huchting J; Kuzikov M; Reinshagen J; Pahl A; von Berlin L; Gadiya Y; Zaliani A; Ballante F; Seashore-Ludlow B; Vallin M; Kalman A; Qian K; Axelsson H; Asp E; Tampere M; Östling P; Tanoli Z; Aittokallio T; Spjuth O; Gustavsson A-L; Jenmalm-Jensen A; Gribbon P
• Article: PATTERNS. 2026;7(4):101453

  Experimental and machine learning-based exploration of repurposed drugs reveals chemical features underlying phospholipidosis

  Kuzikov M; Kalman A; Karki R; Reinshagen J; Huchting J; Qian K; Axelsson H; Tampere M; Ostling P; Seashore-Ludlow B; Gadiya Y; Gribbon P; Zaliani A
• Article: NPJ PRECISION ONCOLOGY. 2026;10(1):117

  Midostaurin response in AML is shaped by a progenitor-like cell state selectively targeted by SMAC mimetics

  Struyf N; Gezelius H; Lundmark A; Barizza C; Ploeger H; Rico Pizarro L; Vesterlund M; Mermelekas G; Osterroos A; Bohlin A; Bengtzen S; Hamberg Levedahl K; Jafari R; Orre LM; Lehtio J; Ostling P; Seashore-Ludlow B; Nordlund J; Lehmann S; Kallioniemi O; Erkers T
• Doctoral thesis: 2026

  Integrative analysis of morphological and chemical signatures for understanding drug perturbations in diverse cancer cell models

  Sharma O
• Doctoral thesis: 2025

  Functional precision medicine approaches to identify novel therapeutic strategies in ovarian cancer

  Gudoityte G
• Article: BIOMEDICINE & PHARMACOTHERAPY. 2025;191:118447

  Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing.

  Tampere M; H Le T; Asp E; Kalman A; Kaimal JM; Njenda D; Bäckström A; Axelsson U; Xu H; Ouyang W; Axelsson H; Marabita F; Moussaud-Lamodière E; Sepulveda CO; Seashore-Ludlow B; Vernersson C; Mirazimi A; Lundberg E; Östling P; Stadler C
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2025;102(4):e70055

  Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma

  Qu H; Neog M; Palmblad K; Sundberg E; Lovquist A; Melen E; Aulin C; Harris HE
• Article: CELL. 2025;188(19):5142-5156.e23

  GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity

  Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandström A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Grätz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T
• Corrigendum: CELL. 2025;188(19):5429-5431

  GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity (vol. 188, pg. 5142, 2025)

  Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandstrom A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Gratz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T
• Article: MOLECULAR ONCOLOGY. 2025;19(9):2574-2593

  Systematic profiling of cancer-fibroblast interactions reveals drug combinations in ovarian cancer

  Gudoityte G; Sharma O; Leuenberger L; Wallin E; Fernebro J; Ostling P; Bergstroem R; Lindberg J; Joneborg U; Kallioniemi O; Seashore-Ludlow B
• Preprint: BIORXIV. 2025

  Morphological cell profiling for drug repurposing against SARS-CoV-2 infection

  Asp E; Rietdijk J; Tampere M; Axelsson H; Njenda D; Potdar S; Kalman A; Georgieva P; Lapins M; Ballante F; Soler A; de Kort M; Aittokallio T; Zaliani A; Kuzikov M; Gribbon P; Lo D; Carreras-Puigvert J; Seashore-Ludlow B; Spjuth O; Östling P
• Article: FRONTIERS IN IMMUNOLOGY. 2025;16:1599747

  Inflammation-profiling reveals activated pathways and biomarkers with predictive potential in oligoarticular juvenile idiopathic arthritis

  Wen X; Aulin C; Sundberg E; Qu H; Struglics A; Merritt A-S; Melen E; Altman M; Harris HE
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Medarbetare och kontakt

Gruppledare

• 

  Brinton Seashore-Ludlow

  Senior Forskningsspecialist | Docent

  Telefon +46852487873

  E-postadress brinton.seashore-ludlow@ki.se

Alla medarbetare i gruppen

• 

  Greta Gudoityte

  Anknuten till Forskning

  Telefon +46852482343

  E-postadress greta.gudoityte@ki.se
• 

  Mariam Haffa

  Postdoktorala Studier

  E-postadress mariam.haffa@ki.se
• 

  Karolina Juhani

  Doktorand

  E-postadress karolina.juhani@ki.se
• 

  Praerona Murad

  Doktorand

  E-postadress praerona.murad@ki.se
• 

  Heshuang Qu

  Postdoktor

  E-postadress heshuang.qu@ki.se
• Mads Ringholm Hansen

  Doktorand

  E-postadress mads.ringholm.hansen@ki.se
• 

  Osheen Sharma

  Anknuten till Forskning

  E-postadress osheen.sharma@ki.se

Vår forskargrupp är en del av SciLifeLab

Foto: SciLifeLab

Vår forskargrupp är en del av SciLifeLab

SciLifeLab är ett nationellt samarbete mellan flera svenska lärosäten som samverkar med hälsovård, industri, myndigheter och internationella organisationer. Denna ledande nationella forskningsinfrastruktur och forskningsmiljö inom området molekylär biovetenskap tillhandahåller avancerade teknologier och expertis för grund- och tillämpad livsvetenskap.