About our research
Our research focuses on developing functional precision medicine approaches that enable direct measurement of drug response in patient-derived samples and other clinically relevant disease models. By combining functional drug testing with molecular and phenotypic profiling, we investigate the mechanisms that determine treatment sensitivity and resistance, with the goal of improving patient stratification and individualised therapy.
A major focus of our team is the use of near-patient models to identify therapeutic vulnerabilities, discover predictive biomarkers, and develop rational treatment combinations. We use and develop chemical biology approaches, including high-throughput drug perturbation, high-content imaging, and phenotypic profiling, to study drug response and functional biology at scale and at single-cell resolution.
By integrating chemical perturbation with patient-derived models and systems-level analyses, we investigate how cellular heterogeneity and plasticity shape therapeutic response and the emergence of drug resistance. Our goal is to translate these mechanistic insights into more precise treatment strategies and ultimately improve therapeutic decision-making for individual patients.
