Nya riktade cancerbehandlingar för att övervinna läkemedelsresistens – Katja Pokrovskaja Tamms team

Publikationer

Utvalda publikationer

• Article: NATURE COMMUNICATIONS. 2022;13(1):1691

  Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

  Leo IR; Aswad L; Stahl M; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi RN; Gracia-Villacampa E; Östling P; Kallioniemi OP; Tamm KP; Siavelis I; Lehtiö J; Vesterlund M; Jafari R
• Article: SCIENTIFIC REPORTS. 2021;11(1):11023

  PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma.

  Vidarsdottir L; Azimi A; Das I; Sigvaldadottir I; Suryo Rahmanto A; Petri A; Kauppinen S; Ingvar C; Jönsson G; Olsson H; Frostvik Stolt M; Tuominen R; Sangfelt O; Pokrovskaja Tamm K; Hansson J; Grandér D; Egyházi Brage S; Johnsson P
• Article: MELANOMA RESEARCH. 2020;30(5):443-454

  Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib.

  Vidarsdottir L; Fernandes RV; Zachariadis V; Das I; Edsbäcker E; Sigvaldadottir I; Azimi A; Höiom V; Hansson J; Grandér D; Egyházi Brage S; Pokrovskaja Tamm K
• Article: SCIENCE ADVANCES. 2020;6(12):eaax7945

  Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.

  Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grandér D; Arnér ESJ; Tamm KP; Page BDG
• Article: SCIENTIFIC REPORTS. 2019;9(1):536

  STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes.

  Edsbäcker E; Serviss JT; Kolosenko I; Palm-Apergi C; De Milito A; Tamm KP
• Article: CANCER LETTERS. 2018;435:32-43

  Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib.

  Dyczynski M; Yu Y; Otrocka M; Parpal S; Braga T; Henley AB; Zazzi H; Lerner M; Wennerberg K; Viklund J; Martinsson J; Grandér D; De Milito A; Pokrovskaja Tamm K
• Article: CELL DEATH & DISEASE. 2018;9(9):846

  Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment.

  Dyczynski M; Vesterlund M; Björklund A-C; Zachariadis V; Janssen J; Gallart-Ayala H; Daskalaki E; Wheelock CE; Lehtiö J; Grandér D; Tamm KP; Nilsson R
• Article: PLOS ONE. 2017;12(6):e0178844

  Identification of novel small molecules that inhibit STAT3-dependent transcription and function.

  Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Palm Apergi C; Helleday T; Tamm KP; Page BDG; Grander D
• Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(4):e51-e61

  Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs.

  Kolosenko I; Fryknäs M; Forsberg S; Johnsson P; Cheon H; Holvey-Bates EG; Edsbäcker E; Pellegrini P; Rassoolzadeh H; Brnjic S; Larsson R; Stark GR; Grandér D; Linder S; Tamm KP; De Milito A
• Article: EXPERIMENTAL CELL RESEARCH. 2013;319(5):600-611

  An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.

  Lin H; Kolosenko I; Björklund A-C; Protsyuk D; Österborg A; Grandér D; Tamm KP
• Article: BLOOD CANCER JOURNAL. 2011;1(7):e31

  Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells.

  Buentke E; Nordström A; Lin H; Björklund A-C; Laane E; Harada M; Lu L; Tegnebratt T; Stone-Elander S; Heyman M; Söderhäll S; Porwit A; Ostenson C-G; Shoshan M; Tamm KP; Grandér D
• Article: EXPERIMENTAL CELL RESEARCH. 2011;317(1):9-19

  Activation of STAT1 is required for interferon-alpha-mediated cell death.

  Arulampalam V; Kolosenko I; Hjortsberg L; Björklund A-C; Grandér D; Tamm KP
• Article: CELL DEATH AND DIFFERENTIATION. 2009;16(7):1018-1029

  Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.

  Laane E; Tamm KP; Buentke E; Ito K; Kharaziha P; Oscarsson J; Corcoran M; Björklund A-C; Hultenby K; Lundin J; Heyman M; Söderhäll S; Mazur J; Porwit A; Pandolfi PP; Zhivotovsky B; Panaretakis T; Grandér D

Medlemmar och kontakt

Gruppledare

• 

  Katja Pokrovskaja Tamm

  Projektsamordnare | Docent

  E-postadress katja.pokrovskaja@ki.se

Alla medlemmar i gruppen

• 

  Henri Colyn Bwanika

  Anknuten till Forskning

  E-postadress henri.colyn.bwanika@ki.se
• Angelo De Milito

  Anknuten till Forskning | Docent

  E-postadress angelo.de-milito@ki.se
• 

  Katja Pokrovskaja Tamm

  Projektsamordnare | Docent

  E-postadress katja.pokrovskaja@ki.se