KCTT publication list - Strains

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.
Kremer LS, Bozhilova LV, Rubalcava-Gracia D, Filograna R, Upadhyay M, Koolmeister C, Chinnery PF, Larsson NG
PLoS Genet 2023 Jan;19(1):e1010573

Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool.
von Hoesslin M, Kuhlmann M, de Almeida GP, Kanev K, Wurmser C, Gerullis AK, Roelli P, Berner J, Zehn D
Sci Immunol 2022 Nov;7(77):eabp9553

High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo.
Bonekamp NA, Jiang M, Motori E, Garcia Villegas R, Koolmeister C, Atanassov I, Mesaros A, Park CB, Larsson NG
Life Sci Alliance 2021 Nov;4(11):

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Zhang J, Gurusaran M, Fujiwara Y, Zhang K, Echbarthi M, Vorontsov E, Guo R, Pendlebury DF, Alam I, Livera G, Emmanuelle M, Wang PJ, Nandakumar J, Davies OR, Shibuya H
Nat Commun 2020 Apr;11(1):2055

Severe mtDNA depletion and dependency on catabolic lipid metabolism in DGUOK knockout mice.
Zhou X, Curbo S, Zhao Q, Krishnan S, Kuiper R, Karlsson A
Hum Mol Genet 2019 Sep;28(17):2874-2884

Foxc2 is essential for podocyte function.
Nilsson D, Heglind M, Arani Z, Enerbäck S
Physiol Rep 2019 May;7(9):e14083

Failure to Genotype: A Cautionary Note on an Elusive loxP Sequence.
Kreuger J, O'Callaghan P
PLoS One 2016 ;11(10):e0165012

Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice.
Kasztura M, Sniezewski L, Laszkiewicz A, Majkowski M, Kobak K, Peczek K, Janik S, Kapusniak V, Miazek A, Cebrat M, Kisielow P
Arch Immunol Ther Exp (Warsz) 2016 Aug;64(4):311-9

A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5.
Norum JH, Bergström Å, Andersson AB, Kuiper RV, Hoelzl MA, Sørlie T, Toftgård R
Dev Biol 2015 Aug;404(2):35-48

Evaluation of TRAP-sequencing technology with a versatile conditional mouse model.
Hupe M, Li MX, Gertow Gillner K, Adams RH, Stenman JM
Nucleic Acids Res 2014 Jan;42(2):e14

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
Bestas B, Moreno PM, Blomberg KE, Mohammad DK, Saleh AF, Sutlu T, Nordin JZ, Guterstam P, Gustafsson MO, Kharazi S, Piątosa B, Roberts TC, Behlke MA, Wood MJ, Gait MJ, Lundin KE, El Andaloussi S, Månsson R, Berglöf A, Wengel J, Smith CI
J Clin Invest 2014 Sep;124(9):4067-81

MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.
Terzioglu M, Ruzzenente B, Harmel J, Mourier A, Jemt E, López MD, Kukat C, Stewart JB, Wibom R, Meharg C, Habermann B, Falkenberg M, Gustafsson CM, Park CB, Larsson NG
Cell Metab 2013 Apr;17(4):618-26

Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.
Krishnan S, Zhou X, Paredes JA, Kuiper RV, Curbo S, Karlsson A
J Biol Chem 2013 Feb;288(7):5072-9

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs.
Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Cámara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, Stewart JB, Gustafsson CM, Larsson NG
EMBO J 2012 Jan;31(2):443-56

Generation of ERα-floxed and knockout mice using the Cre/LoxP system.
Antonson P, Omoto Y, Humire P, Gustafsson JÅ
Biochem Biophys Res Commun 2012 Aug;424(4):710-6

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo.
Sterky FH, Lee S, Wibom R, Olson L, Larsson NG
Proc Natl Acad Sci U S A 2011 Aug;108(31):12937-42

Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells.
Nazarenko I, Hedrén A, Sjödin H, Orrego A, Andrae J, Afink GB, Nistér M, Lindström MS
PLoS One 2011 Apr;6(4):e18303

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.
Deng Q, Andersson E, Hedlund E, Alekseenko Z, Coppola E, Panman L, Millonig JH, Brunet JF, Ericson J, Perlmann T
Development 2011 Aug;138(16):3399-408

MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.
Cámara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T, Erdjument-Bromage H, Tempst P, Hallberg BM, Gustafsson CM, Larsson NG
Cell Metab 2011 May;13(5):527-39

The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons.
Wallis K, Dudazy S, van Hogerlinden M, Nordström K, Mittag J, Vennström B
Mol Endocrinol 2010 Oct;24(10):1904-16

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I
EMBO J 2010 Jul;29(14):2421-32

Thyroid hormone receptor alpha can control action potential duration in mouse ventricular myocytes through the KCNE1 ion channel subunit.
Mansén A, Tiselius C, Sand P, Fauconnier J, Westerblad H, Rydqvist B, Vennström B
Acta Physiol (Oxf) 2010 Feb;198(2):133-42

Vang-like protein 2 and Rac1 interact to regulate adherens junctions.
Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T
J Cell Sci 2010 Feb;123(Pt 3):472-83

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism.
Horn Z, Ringstedt T, Blaesse P, Kaila K, Herlenius E
Eur J Neurosci 2010 Jun;31(12):2142-55

Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion.
Hägglund M, Borgius L, Dougherty KJ, Kiehn O
Nat Neurosci 2010 Feb;13(2):246-52

A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons.
Borgius L, Restrepo CE, Leao RN, Saleh N, Kiehn O
Mol Cell Neurosci 2010 Nov;45(3):245-57

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.
Nuber S, Franck T, Wolburg H, Schumann U, Casadei N, Fischer K, Calaminus C, Pichler BJ, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R, Riess O
Neurogenetics 2010 Feb;11(1):107-20

Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome.
Metodiev MD, Lesko N, Park CB, Cámara Y, Shi Y, Wibom R, Hultenby K, Gustafsson CM, Larsson NG
Cell Metab 2009 Apr;9(4):386-97

Nogo receptor 1 regulates formation of lasting memories.
Karlén A, Karlsson TE, Mattsson A, Lundströmer K, Codeluppi S, Pham TM, Bäckman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brené S, Olson L
Proc Natl Acad Sci U S A 2009 Dec;106(48):20476-81

GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background.
Hede SM, Hansson I, Afink GB, Eriksson A, Nazarenko I, Andrae J, Genove G, Westermark B, Nistér M
Glia 2009 Aug;57(11):1143-53

Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice.
Zhou X, Solaroli N, Bjerke M, Stewart JB, Rozell B, Johansson M, Karlsson A
Hum Mol Genet 2008 Aug;17(15):2329-35

Noninvasive in vivo imaging of pancreatic islet cell biology.
Speier S, Nyqvist D, Cabrera O, Yu J, Molano RD, Pileggi A, Moede T, Köhler M, Wilbertz J, Leibiger B, Ricordi C, Leibiger IB, Caicedo A, Berggren PO
Nat Med 2008 May;14(5):574-8

Spinal cord injury reveals multilineage differentiation of ependymal cells.
Meletis K, Barnabé-Heider F, Carlén M, Evergren E, Tomilin N, Shupliakov O, Frisén J
PLoS Biol 2008 Jul;6(7):e182

Retrograde signaling onto Ret during motor nerve terminal maturation.
Baudet C, Pozas E, Adameyko I, Andersson E, Ericson J, Ernfors P
 

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
Andäng M, Hjerling-Leffler J, Moliner A, Lundgren TK, Castelo-Branco G, Nanou E, Pozas E, Bryja V, Halliez S, Nishimaru H, Wilbertz J, Arenas E, Koltzenburg M, Charnay P, El Manira A, Ibañez CF, Ernfors P
Nature 2008 Jan;451(7177):460-4

MTERF3 is a negative regulator of mammalian mtDNA transcription.
Park CB, Asin-Cayuela J, Cámara Y, Shi Y, Pellegrini M, Gaspari M, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Falkenberg M, Gustafsson CM, Larsson NG
Cell 2007 Jul;130(2):273-85

Regulation of epsilon germline transcription and switch region mutations by IgH locus 3' enhancers in transgenic mice.
Laurencikiene J, Tamosiunas V, Severinson E
Blood 2007 Jan;109(1):159-67

Overexpression of human wildtype torsinA and human DeltaGAG torsinA in a transgenic mouse model causes phenotypic abnormalities.
Grundmann K, Reischmann B, Vanhoutte G, Hübener J, Teismann P, Hauser TK, Bonin M, Wilbertz J, Horn S, Nguyen HP, Kuhn M, Chanarat S, Wolburg H, Van der Linden A, Riess O
Neurobiol Dis 2007 Aug;27(2):190-206

Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase.
Friebe A, Mergia E, Dangel O, Lange A, Koesling D
Proc Natl Acad Sci U S A 2007 May;104(18):7699-704

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.
Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG
Proc Natl Acad Sci U S A 2007 Jan;104(4):1325-30

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Bichelmeier U, Schmidt T, Hübener J, Boy J, Rüttiger L, Häbig K, Poths S, Bonin M, Knipper M, Schmidt WJ, Wilbertz J, Wolburg H, Laccone F, Riess O
J Neurosci 2007 Jul;27(28):7418-28

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.
Svärd J, Heby-Henricson K, Persson-Lek M, Rozell B, Lauth M, Bergström A, Ericson J, Toftgård R, Teglund S
Dev Cell 2006 Feb;10(2):187-97

Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis.
Sur I, Rozell B, Jaks V, Bergström A, Toftgård R
J Cell Sci 2006 Sep;119(Pt 17):3593-601

Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system.
Mergia E, Friebe A, Dangel O, Russwurm M, Koesling D
J Clin Invest 2006 Jun;116(6):1731-7

The fate of mosaic aneuploid embryos during mouse development.
Lightfoot DA, Kouznetsova A, Mahdy E, Wilbertz J, Höög C
Dev Biol 2006 Jan;289(2):384-94

Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc.
Kobayashi M, Hjerling-Leffler J, Ernfors P
Cell Tissue Res 2006 Jan;323(1):81-90

Genetic visualization of neurogenesis.
Carlén M, Meletis K, Barnabé-Heider F, Frisén J
Exp Cell Res 2006 Sep;312(15):2851-9

Ectopic expression of C/EBPalpha in the lung epithelium disrupts late lung development.
Berg T, Didon L, Nord M
Am J Physiol Lung Cell Mol Physiol 2006 Oct;291(4):L683-93

SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity.
Silva JP, Shabalina IG, Dufour E, Petrovic N, Backlund EC, Hultenby K, Wibom R, Nedergaard J, Cannon B, Larsson NG
EMBO J 2005 Dec;24(23):4061-70

Increased Wnt levels in the neural tube impair the function of adherens junctions during neurulation.
Shariatmadari M, Peyronnet J, Papachristou P, Horn Z, Sousa KM, Arenas E, Ringstedt T
Mol Cell Neurosci 2005 Nov;30(3):437-51

Conditional expression of a glucocorticoid receptor transgene in thymocytes reveals a role for thymic-derived glucocorticoids in thymopoiesis in vivo.
Pazirandeh A, Jondal M, Okret S
Endocrinology 2005 Jun;146(6):2501-7

Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.
Lundkvist J, Zhu S, Hansson EM, Schweinhardt P, Miao Q, Beatus P, Dannaeus K, Karlström H, Johansson CB, Viitanen M, Rozell B, Spenger C, Mohammed A, Kalimo H, Lendahl U
Genesis 2005 Jan;41(1):13-22

Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG
Nature 2004 May;429(6990):417-23

Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine.
Sieber BA, Kuzmin A, Canals JM, Danielsson A, Paratcha G, Arenas E, Alberch J, Ogren SO, Ibáñez CF
Mol Cell Neurosci 2004 Jul;26(3):418-28

Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.
McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D
Mol Biol Cell 2004 Sep;15(9):4278-88

ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse.
Jörnvall H, Reissmann E, Andersson O, Mehrkash M, Ibáñez CF
Mol Cell Biol 2004 Nov;24(21):9383-9

Laminin alpha1 chain reduces muscular dystrophy in laminin alpha2 chain deficient mice.
Gawlik K, Miyagoe-Suzuki Y, Ekblom P, Takeda S, Durbeej M
Hum Mol Genet 2004 Aug;13(16):1775-84

Mitochondrial transcription factor A regulates mtDNA copy number in mammals.
Ekstrand MI, Falkenberg M, Rantanen A, Park CB, Gaspari M, Hultenby K, Rustin P, Gustafsson CM, Larsson NG
Hum Mol Genet 2004 May;13(9):935-44

Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin.
Levchenko T, Aase K, Troyanovsky B, Bratt A, Holmgren L
J Cell Sci 2003 Sep;116(Pt 18):3803-10

Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction.
Antonson P, Schuster GU, Wang L, Rozell B, Holter E, Flodby P, Treuter E, Holmgren L, Gustafsson JA
Mol Cell Biol 2003 Feb;23(4):1260-8

BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development.
Agerman K, Hjerling-Leffler J, Blanchard MP, Scarfone E, Canlon B, Nosrat C, Ernfors P
Development 2003 Apr;130(8):1479-91

Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1.
Tinnikov A, Nordström K, Thorén P, Kindblom JM, Malin S, Rozell B, Adams M, Rajanayagam O, Pettersson S, Ohlsson C, Chatterjee K, Vennström B
EMBO J 2002 Oct;21(19):5079-87

Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis.
Pazirandeh A, Xue Y, Prestegaard T, Jondal M, Okret S
FASEB J 2002 May;16(7):727-9

Nestin enhancer requirements for expression in normal and injured adult CNS.
Johansson CB, Lothian C, Molin M, Okano H, Lendahl U
J Neurosci Res 2002 Sep;69(6):784-94

Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice.
Zhang FP, Poutanen M, Wilbertz J, Huhtaniemi I
Mol Endocrinol 2001 Jan;15(1):172-83

A mouse model for adenovirus gene delivery.
Tallone T, Malin S, Samuelsson A, Wilbertz J, Miyahara M, Okamoto K, Poellinger L, Philipson L, Pettersson S
Proc Natl Acad Sci U S A 2001 Jul;98(14):7910-5

Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice.
Saltó C, Kindblom JM, Johansson C, Wang Z, Gullberg H, Nordström K, Mansén A, Ohlsson C, Thorén P, Forrest D, Vennström B
Mol Endocrinol 2001 Dec;15(12):2115-28

The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.
Yuan L, Liu JG, Zhao J, Brundell E, Daneholt B, Höög C
Mol Cell 2000 Jan;5(1):73-83

Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor.
Chomez P, Neveu I, Mansén A, Kiesler E, Larsson L, Vennström B, Arenas E
Development 2000 Apr;127(7):1489-98