Research group Birgitta Sander & Birger Christensson

Molecular pathogenesis of malignant lymphoma. The goal with this project is to increase our understanding of the molecular pathogenesis of malignant lymphoma in order to identify markers for aggressive and indolent disease and find new potential therapeutic targets. Specifically we investigate the role of the SOXC transcription factors, the cannabinoid receptors and lipid mediators belonging to the endocannabinoid system.

The project aims to increase the knowledge on pathogenetic mechanisms in lymphoproliferative disorders and lymphoma. Special focus is on 1) the functional role of the cannabinoid receptors and their physiological agonists - arachidonic acid derivatives produced by cells in the lymphoma microenvironment. 2) the functional role of the SOXC transcription factors in lymphoma. 3) genetic alterations associated with tumor progression and relapse in mantle cell lymphoma. Functional studies are done in well-characterized cell lines and in primary lymphoma cells. NGS and other methods are used for characterizing genetic and epigenetic changes, analyze gene and protein expression. This project will lead to increased knowledge on mechanisms underlying lymphoma pathogenesis and may open up for more individualized therapy. It will lead to better understanding of disease progression and to find markers and mutations that can guide the choice of therapy already at the time of diagnosis.

Publications

Selected publications

Members and contact

Group leader

All members of the group

Teaching assignments

We participate in the education of medical doctors, dentists, nurses and biomedical personnel.

Research techniques

  • Molecular biology including gene expression profiling
  • Quantitative PCR, siRNA
  • Cellular techniques including isolation and culture of primary cells and cell lines
  • Various methods for analyzing cell proliferation survival and cell death
  • 8 color flow cytometry and cell sorting
  • Analysis of cell signalling
  • Microscopy methods including robotized immunohistochemistry, confocal microscopy and electron microscopy