Kristian Dreij
About me
Head of Unit and Research Group Leader at the Institute of Environmental Medicine, Karolinska Institutet.
I received my Ph.D. in Toxicology in 2005 from the laboratory of Prof. Jernström at KI. My research focused on the protective role of cellular metabolism and DNA repair against carcinogenic environmental contaminants. Following my Ph.D., I worked as a postdoctoral fellow in the laboratory of Prof. Scicchitano at the Department of Biology, New York University, where our project focused on the effects of chemical interactions with DNA and how cells deal with the resulting damage.
My current research aims to shift the focus from studying the genotoxic effects of single chemicals to understanding the effects of complex mixtures found in our environment. We investigate genotoxicity in exposed populations and on human cells using environmental samples. This allows us to identify mechanisms of mixture toxicity and improve health risk assessment of environmental pollution. Current projects focus on urban and rural air pollution, and past projects have investigated genotoxic mixture effects in the context of soil contamination, indoor air quality in pre-schools, and occupational exposure to pesticides in Bolivia. We also study the effects of genotoxic chemicals and mixtures on transcription and replication fidelity by analyzing RNA and DNA mutagenesis.
In 2016, I was appointed Associate Professor/Docent in Toxicology, and I am also Deputy Program Director of the global Master's Programme in Toxicology at Karolinska Institutet.
Selected publications
- Article: ENVIRONMENT INTERNATIONAL. 2024;190:108942
- Article: ENVIRONMENT INTERNATIONAL. 2022;166:107345
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2021;129(6):67008
- Article: ENVIRONMENT INTERNATIONAL. 2020;143:105913
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2019;695:133942
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(18):4731-4736
- Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2017;51(15):8805-8814
- Article: NUCLEIC ACIDS RESEARCH (NAR). 2017;45(11):6520-6529
- Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2015;49(6):3869-3877
- Review: TOXICOLOGY. 2014;321:27-39
Articles
- Journal article: ENVIRONMENTAL POLLUTION. 2024;363(Pt 2):125189
- Article: ATMOSPHERIC RESEARCH. 2024;305:107423
- Article: ENVIRONMENT INTERNATIONAL. 2024;189:108798
- Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2024;108:104453
- Article: TOXICOLOGY IN VITRO. 2023;91:105628
- Article: ENVIRONMENTAL RESEARCH. 2023;227:115787
- Article: ENVIRONMENTAL POLLUTION. 2023;316(Pt 1):120510
- Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2022;96:103999
- Article: FOOD CONTROL. 2022;132:108528
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2022;63(1):4-17
- Article: AUTOPHAGY. 2021;17(5):1259-1277
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2021;755(Pt 1):142709
- Article: VASCULAR MEDICINE. 2021;26(1):3-10
- Article: SCIENTIFIC REPORTS. 2020;10(1):13513
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):730-742
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2020;61(5):560-573
- Article: ENVIRONMENTAL RESEARCH. 2020;182:108989
- Article: ENVIRONMENTAL POLLUTION. 2020;256:113381
- Journal article: ENVIRONMENTAL EPIDEMIOLOGY. 2019;3(Supplement 1):22-23
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2019;60(7):607-616
- Article: CARCINOGENESIS. 2019;40(4):580-591
- Article: ENVIRONMENTAL POLLUTION. 2019;246:678-687
- Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy565.p2625
- Article: REDOX BIOLOGY. 2018;17:171-179
- Journal article: FRONTIERS IN MARINE SCIENCE. 2018;5
- Article: ANTIOXIDANTS AND REDOX SIGNALING. 2017;26(6):229-246
- Article: MUTAGENESIS. 2017;32(1):127-137
- Article: MUTAGENESIS. 2016;31(6):643-653
- Article: TOXICOLOGY RESEARCH. 2016;5(3):788-799
- Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2015;49(5):3101-3109
- Article: TOXICOLOGY LETTERS. 2014;229(1):25-32
- Article: JOURNAL OF CHROMATOGRAPHY A. 2014;1355:100-106
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2014;55(6):510-517
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;266(3):408-418
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2012;25(4):862-872
- Article: PLOS ONE. 2012;7(8):e43209
- Article: DNA REPAIR. 2011;10(8):877-886
- Article: PLOS ONE. 2011;6(8):e23128
- Article: NUCLEIC ACIDS RESEARCH (NAR). 2010;38(22):8178-8187
- Article: CARCINOGENESIS. 2010;31(6):1149-1157
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2003;16(5):590-597
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(2):170-179
- Show more
All other publications
- Review: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2024;21(3):305
- Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2022;32(5):782
- Corrigendum: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):768
- Review: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2019;16(23):E4718-4718
- Published conference paper: JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS. 2014;262:244-260
- Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S68-S69
- Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S60-S61
- Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S54-S55
- Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S35
- Book chapter: THE CHEMICAL BIOLOGY OF DNA DAMAGE. 2010;p. 399-437
- Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2005;18(4):655-664
- Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2004;24(4-5):549-566
- Published conference paper: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(6):825-831
- Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):947-953
- Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2002;22(3-4):823-829
- Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):91-94
Grants
- Swedish Research Council1 January 2023 - 31 December 2026
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2023 - 31 December 2026
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2022 - 31 December 2025
- Swedish Research Council1 January 2020 - 31 December 2021
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2020 - 31 December 2022
- Swedish Foundation for International Cooperation in Research and Higher Education1 January 2020 - 1 January 2023
- Swedish Research Council1 January 2018 - 31 December 2021
- Swedish Research Council1 January 2017 - 31 December 2019
- Measurement of PAHs in indoor and outdoor air at preschools in Stockholm.Stockholm Regional Council1 February 2016 - 31 December 2018
- Swedish International Development Cooperation Agency1 January 2013 - 1 January 2021
- Swedish Research Council1 January 2013 - 31 December 2016
- Swedish Research Council1 January 2012 - 31 December 2014
- FP7 Marie Curie International Reintegration Grants1 May 2010 - 1 May 2012
Employments
- Principal Researcher, Institute of Environmental Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2005
Leadership and responsibility assignments
- Deputy Programme Director, Master's Programme in Toxicology, Institute of Environmental Medicine, Karolinska Institute, 2012-
Supervisor
- Jessika Barrón Cuenca, Genotoxic effects among Bolivian farmers exposed to mixtures of pesticides : population and in vitro based studies, https://hdl.handle.net/10616/47170
- Monika Ezerskyte, The impact of transcriptional mutagenesis on cellular homeostasis, https://hdl.handle.net/10616/46502
- Carla Martins, Carcinogenic toxicants and emerging pollutants. A comprehensive case-study on toxicant interactions in vivo and in vitro: from Molecular Toxicology to Environmental Risk Assessment, http://hdl.handle.net/10362/162137
- Sandeep Kadekar, Gender differences in chemical carcinogenesis, https://hdl.handle.net/10616/41811