Kristian Dreij
About me
Head of Unit and Research Group Leader at the Institute of Environmental Medicine, Karolinska Institutet.
I earned my Ph.D. in Toxicology in 2005 from the laboratory of Prof. Jernström at KI. My research focused on the protective role of cellular metabolism and DNA repair against carcinogenic environmental contaminants. Following my Ph.D., I worked as a postdoctoral fellow in the laboratory of Prof. Scicchitano at the Department of Biology, New York University, where our project focused on the effects of chemical interactions with DNA and how cells deal with the resulting damage.
My current research aims to shift the focus from studying the genotoxic effects of single chemicals to understanding the effects of complex mixtures found in our environment. We investigate genotoxicity in exposed populations and on human cells using environmental samples. This allows us to identify mechanisms of mixture toxicity and improve health risk assessment of environmental pollution. Current projects focus on urban and rural air pollution, and past projects have investigated genotoxic mixture effects in the context of soil contamination, indoor air quality in pre-schools, and occupational exposure to pesticides. We also study the effects of genotoxic chemicals and mixtures on transcription and replication fidelity by analyzing RNA and DNA mutagenesis.
In 2016, I was appointed Associate Professor/Docent in Toxicology, and I am also Deputy Program Director of the global Master's Programme in Toxicology at Karolinska Institutet.
Articles
- Article: ENVIRONMENTAL POLLUTION. 2024;363(Pt 2):125189
- Article: ATMOSPHERIC RESEARCH. 2024;305:107423
- Article: ENVIRONMENT INTERNATIONAL. 2024;189:108798
- Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2024;108:104453
- Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2024;21(3):305
- Article: TOXICOLOGY IN VITRO. 2023;91:105628
- Article: ENVIRONMENTAL RESEARCH. 2023;227:115787
- Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2022;96:103999
- Article: FOOD CONTROL. 2022;132:108528
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2022;63(1):4-17
- Article: AUTOPHAGY. 2021;17(5):1259-1277
- Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2021;755(Pt 1):142709
- Article: VASCULAR MEDICINE. 2021;26(1):3-10
- Article: SCIENTIFIC REPORTS. 2020;10(1):13513
- Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2020;30(4):730-742
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2020;61(5):560-573
- Article: ENVIRONMENTAL RESEARCH. 2020;182:108989
- Article: ENVIRONMENTAL POLLUTION. 2020;256:113381
- Journal article: ENVIRONMENTAL EPIDEMIOLOGY. 2019;3(Supplement 1):22-23
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2019;60(7):607-616
- Article: CARCINOGENESIS. 2019;40(4):580-591
- Article: ENVIRONMENTAL POLLUTION. 2019;246:678-687
- Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy565.p2625
- Article: REDOX BIOLOGY. 2018;17:171-179
- Journal article: FRONTIERS IN MARINE SCIENCE. 2018;5
- Article: ANTIOXIDANTS & REDOX SIGNALING. 2017;26(6):229-246
- Article: MUTAGENESIS. 2017;32(1):127-137
- Article: MUTAGENESIS. 2016;31(6):643-653
- Article: TOXICOLOGY RESEARCH. 2016;5(3):788-799
- Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2015;49(5):3101-3109
- Article: TOXICOLOGY LETTERS. 2014;229(1):25-32
- Article: JOURNAL OF CHROMATOGRAPHY A. 2014;1355:100-106
- Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2014;55(6):510-517
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;266(3):408-418
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2012;25(4):862-872
- Article: PLOS ONE. 2012;7(8):e43209
- Article: DNA REPAIR. 2011;10(8):877-886
- Article: PLOS ONE. 2011;6(8):e23128
- Article: NUCLEIC ACIDS RESEARCH. 2010;38(22):8178-8187
- Article: CARCINOGENESIS. 2010;31(6):1149-1157
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2003;16(5):590-597
- Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2002;15(2):170-179
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Employments
- Principal Researcher, Institute of Environmental Medicine, Karolinska Institutet, 2022-
- Researcher, Institute of Environmental Medicine, Karolinska Institutet, 2015-2021
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Doctor Of Philosophy, Institute of Environmental Medicine, Karolinska Institutet, 2005
Leadership and responsibility assignments
- Head of unit, Institute of Environmental Medicine, Karolinska Institutet, 2022-
- Deputy Programme Director, Master's Programme in Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 2012-
Supervision
- Jessika Barrón Cuenca, Genotoxic effects among Bolivian farmers exposed to mixtures of pesticides : population and in vitro based studies, https://hdl.handle.net/10616/47170
- Monika Ezerskyte, The impact of transcriptional mutagenesis on cellular homeostasis, https://hdl.handle.net/10616/46502
- Carla Martins, Carcinogenic toxicants and emerging pollutants. A comprehensive case-study on toxicant interactions in vivo and in vitro: from Molecular Toxicology to Environmental Risk Assessment, http://hdl.handle.net/10362/162137
- Sandeep Kadekar, Gender differences in chemical carcinogenesis, https://hdl.handle.net/10616/41811