Neuroimmunovascular biology – Harald Lund's team

Publications

Selected publications

• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675

  CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier

  Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
• Preprint: BIORXIV. 2023

  Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

  Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
• Article: GLIA. 2020;68(7):1466-1478

  Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice

  Zhu K; Pieber M; Han J; Blomgren K; Zhang X-M; Harris RA; Lund H
• Article: NATURE COMMUNICATIONS. 2018;9(1):4845

  Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

  Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
• Article: NATURE IMMUNOLOGY. 2018;19(5):1-7

  Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

  Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA

All publications from group members

• Journal article: NATURE NEUROSCIENCE. 2026;:1-15

  TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration

  Zhu K; Liu Y; Min J-H; Joshua V; Lin J; Li Y; Kreutzmann JC; Guo Y; Xia W; Mohammadi E; Pieber M; Suerth V; Xia Y; Andrusivova Z; Hugnot J-P; Kanatani S; Uhlen P; Lundeberg J; Li X; Fancy SPJ; Sarlus H; Harris RA; Lund H
• Journal article: STAR PROTOCOLS. 2025;6(4):104172

  Protocol for dissection and organotypic explant culture of the neonatal and adult stria vascularis.

  Thulasiram MR; Dabdoub A
• Journal article: OPEN BIOLOGY. 2025;15(10):250141

  Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice

  Reina-Campos M; Gallego-Landin I; Medrano M; Garcia-Baos A; Valverde O
• Journal article: ISCIENCE. 2025;28(2):111832

  Molecular differences between young and mature stria vascularis from organotypic explants and transcriptomics

  Thulasiram AMR; Yamamoto R; Olszewski RT; Gu S; Morell RJ; Hoa M; Dabdoub A
• Article: DEVELOPMENTAL CELL. 2025;60(2):320-336.e9

  Regionalized cell and gene signatures govern esophageal epithelial homeostasis

  Grommisch D; Lund H; Eenjes E; Julien A; Goritz C; Harris RA; Sandberg R; Hagemann-Jensen M; Genander M
• Preprint: BIORXIV. 2024;BIORXIV

  Molecular differences between neonatal and adult stria vascularis from organotypic explants and transcriptomics.

  Thulasiram MR; Yamamoto R; Olszewski RT; Gu S; Morell RJ; Hoa M; Dabdoub A
• Preprint: BIORXIV. 2024

  Regionalized cell and gene signatures govern oesophageal epithelial homeostasis

  Grommisch D; Lund H; Eenjes E; Julien A; Göritz C; Harris R; Sandberg R; Hagemann-Jensen M; Genander M
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675

  CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier

  Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
• Preprint: BIORXIV. 2023

  Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

  Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
• Preprint: BIORXIV. 2023

  A network of CD163⁺macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier

  Lund H; Hunt M; Kurtovic Z; Sandor K; Fereydouni N; Julien A; Göritz C; Han J; Zhu K; Harris R; Lampa J; Haglund L; Yaksh T; Svensson C
• Journal article: CELL HOST & MICROBE. 2022;30(12):1662-1670.e4

  Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans

  Grifoni A; Zhang Y; Tarke A; Sidney J; Rubiro P; Reina-Campos M; Filaci G; Dan JM; Scheuermann RH; Sette A
• Article: EMBO REPORTS. 2022;23(7):e54499

  Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation

  Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Min J-H; Benito-Cuesta I; Lund H; Amor S; Wang J; Zhang X-M; Kutter C; Guerreiro-Cacais AO; Hogberg B; Harris RA
• Article: JOURNAL OF NEUROSCIENCE METHODS. 2022;371:109497

  DRGquant: A new modular AI-based pipeline for 3D analysis of the DRG

  Hunt MA; Lund H; Delay L; Dos Santos GG; Pham A; Kurtovic Z; Telang A; Lee A; Parvathaneni A; Kussick E; Corr M; Yaksh TL
• Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20

  An overlooked subset of Cx3cr1^wt/wt microglia in the Cx3cr1^{CreER-Eyfp/wt} mouse has a repopulation advantage over Cx3cr1^{CreER-Eyfp/wt} microglia following microglial depletion

  Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
• Journal article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:841708

  Hearing Function, Degeneration, and Disease: Spotlight on the Stria Vascularis.

  Thulasiram MR; Ogier JM; Dabdoub A
• Preprint: BIORXIV. 2021

  Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation

  Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Lund H; Amor S; Wang J; Zhang X; Kutter C; Guerreiro Cacais AO; Högberg B; Harris R
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603

  Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion

  Han J; Fan Y; Zhou K; Zhu K; Blomgren K; Lund H; Zhang X-M; Harris RA
• Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077

  Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation.

  Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824

  Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis

  Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
• Article: GLIA. 2020;68(7):1466-1478

  Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice

  Zhu K; Pieber M; Han J; Blomgren K; Zhang X-M; Harris RA; Lund H
• Journal article: EXPERIMENTAL BRAIN RESEARCH. 2020;238(6):1433-1440

  Eye-hand coordination in reaching and grasping vertically moving targets

  Thulasiram MR; Langridge RW; Abbas HH; Marotta JJ
• Preprint: RESEARCH SQUARE. 2020

  Sex-Specific Effects of Microglia-Like Cell Engraftment During Experimental Autoimmune Encephalomyelitis

  Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
• Article: NATURE COMMUNICATIONS. 2018;9(1):4845

  Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

  Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
• Doctoral thesis: 2018

  Regulation of microglia and monocyte function by the cytokine TGF-beta

  Lund H
• Article: NATURE IMMUNOLOGY. 2018;19(5):1-7

  Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

  Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
• Article: NEUROBIOLOGY OF AGING. 2017;60:173-182

  Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells

  Sackmann V; Ansell A; Sackmann C; Lund H; Harris RA; Hallbeck M; Nilsberth C
• Article: BMC BIOINFORMATICS. 2017;18(1):486

  Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies

  Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
• Review: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:234

  Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies

  Lund H; Pieber M; Harris RA
• Article: GLIA. 2016;64(11):1925-1937

  TGFβ Regulates Persistent Neuroinflammation by Controlling Th1 Polarization and ROS Production via Monocyte-Derived Dendritic Cells

  Parsa R; Lund H; Tosevski I; Zhang X-M; Malipiero U; Beckervordersandforth J; Merkler D; Prinz M; Gyllenberg A; James T; Warnecke A; Hillert J; Alfredsson L; Kockum I; Olsson T; Fontana A; Suter T; Harris RA
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553

  BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis

  Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
• Article: GLIA. 2014;62(5):804-817

  Adoptive Transfer of Cytokine-Induced Immunomodulatory Adult Microglia Attenuates Experimental Autoimmune Encephalomyelitis in DBA/1 Mice

  Zhang X-M; Lund H; Mia S; Parsa R; Harris RA
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2014;2:22

  MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies

  Lund H; Gustafsson E; Svensson A; Nilsson M; Berg M; Sunnemark D; von Euler G
• Article: NEUROMOLECULAR MEDICINE. 2013;15(3):458-469

  Role of Individual MARK Isoforms in Phosphorylation of Tau at Ser²⁶² in Alzheimer's Disease

  Gu GJ; Lund H; Wu D; Blokzijl A; Classon C; von Euler G; Landegren U; Sunnemark D; Kamali-Moghaddam M
• Article: BRAIN PATHOLOGY. 2013;23(4):378-389

  Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain

  Lund H; Cowburn RF; Gustafsson E; Stromberg K; Svensson A; Dahllund L; Malinowsky D; Sunnemark D
• Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;33(3):699-713

  Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease

  Gu GJ; Wu D; Lund H; Sunnemark D; Kvist AJ; Milner R; Eckersley S; Nilsson LNG; Agerman K; Landegren U; Kamali-Moghaddam M
• Article: PHYTOTHERAPY RESEARCH. 2011;25(6):851-857

  Dietary Quinic Acid Supplied as the Nutritional Supplement AIO + AC-11® leads to Induction of Micromolar Levels of Nicotinamide and Tryptophan in the Urine

  Pero RW; Lund H
• Article: PHYTOTHERAPY RESEARCH. 2009;23(3):335-346

  Antioxidant Metabolism Induced by Quinic Acid. Increased Urinary Excretion of Tryptophan and Nicotinamide

  Pero RW; Lund H; Leanderson T
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Staff and contact

Group leader

• 

  Harald Lund

  Assistant Professor

  E-mail harald.lund@ki.se

All members of the group

• Martí Bonafonte Casas

  Affiliated to Research

  E-mail marti.bonafonte.casas@ki.se
• Yue Chen

  Affiliated to Research

  E-mail yue.chen@ki.se
• 

  Emilie Linderoth

  Laboratory Coordinator

  E-mail emilie.linderoth@ki.se
• 

  María Reina-Campos

  Phd Student

  E-mail maria.reina.campos@ki.se
• 

  Matsya Thulasiram

  Postdoctoral Studies

  E-mail matsya.thulasiram@ki.se

Visiting address

Karolinska Institutet, Solnavägen 9, Solna, 171 64, Sverige