Harald Lund

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About me

I did my PhD at Karolinska Institutet with Bob Harris on microglial biology (2018). After a postdoc with Tony Yaksh at UC San Diego (2018-2019), I returned to Karolinska Institutet and joined Camilla Svensson's research group as postdoc (2020). Since 2024 I am Assistant Professor and team leader at the Department of Physiology and Pharmacology. We study the blood-nerve barrier during health and disease.

Articles

Article: DEVELOPMENTAL CELL. 2025;60(2):320-336.e9
Regionalized cell and gene signatures govern esophageal epithelial homeostasis
Grommisch D; Lund H; Eenjes E; Julien A; Goritz C; Harris RA; Sandberg R; Hagemann-Jensen M; Genander M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675
CD163⁺ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier
Lund H; Hunt MA; Kurtovic Z; Sandor K; Kagy PB; Fereydouni N; Julien A; Goritz C; Vazquez-Liebanas E; Andaloussi Mae M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
Article: EMBO REPORTS. 2022;23(7):e54499
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation
Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Min J-H; Benito-Cuesta I; Lund H; Amor S; Wang J; Zhang X-M; Kutter C; Guerreiro-Cacais AO; Hogberg B; Harris RA
Article: JOURNAL OF NEUROSCIENCE METHODS. 2022;371:109497
DRGquant: A new modular AI-based pipeline for 3D analysis of the DRG
Hunt MA; Lund H; Delay L; Dos Santos GG; Pham A; Kurtovic Z; Telang A; Lee A; Parvathaneni A; Kussick E; Corr M; Yaksh TL
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
An overlooked subset of Cx3cr1^wt/wt microglia in the Cx3cr1^{CreER-Eyfp/wt} mouse has a repopulation advantage over Cx3cr1^{CreER-Eyfp/wt} microglia following microglial depletion
Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8603-8603
Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion
Han J; Fan Y; Zhou K; Zhu K; Blomgren K; Lund H; Zhang X-M; Harris RA
Article: SCIENCE IMMUNOLOGY. 2020;5(52):eabb5077
Microglial autophagy-associated phagocytosis is essential for recovery from neuroinflammation.
Berglund R; Guerreiro-Cacais AO; Adzemovic MZ; Zeitelhofer M; Lund H; Ewing E; Ruhrmann S; Nutma E; Parsa R; Thessen-Hedreul M; Amor S; Harris RA; Olsson T; Jagodic M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(18):E6824-6824
Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis
Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
Article: GLIA. 2020;68(7):1466-1478
Absence of microglia or presence of peripherally-derived macrophages does not affect tau pathology in young or old hTau mice
Zhu K; Pieber M; Han J; Blomgren K; Zhang X-M; Harris RA; Lund H
Article: NATURE COMMUNICATIONS. 2018;9(1):4845
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: NEUROBIOLOGY OF AGING. 2017;60:173-182
Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells
Sackmann V; Ansell A; Sackmann C; Lund H; Harris RA; Hallbeck M; Nilsberth C
Article: BMC BIOINFORMATICS. 2017;18(1):486
Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies
Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
Article: GLIA. 2016;64(11):1925-1937
TGFβ Regulates Persistent Neuroinflammation by Controlling Th1 Polarization and ROS Production via Monocyte-Derived Dendritic Cells
Parsa R; Lund H; Tosevski I; Zhang X-M; Malipiero U; Beckervordersandforth J; Merkler D; Prinz M; Gyllenberg A; James T; Warnecke A; Hillert J; Alfredsson L; Kockum I; Olsson T; Fontana A; Suter T; Harris RA
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
Article: GLIA. 2014;62(5):804-817
Adoptive Transfer of Cytokine-Induced Immunomodulatory Adult Microglia Attenuates Experimental Autoimmune Encephalomyelitis in DBA/1 Mice
Zhang X-M; Lund H; Mia S; Parsa R; Harris RA
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2014;2:22
MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies
Lund H; Gustafsson E; Svensson A; Nilsson M; Berg M; Sunnemark D; von Euler G
Article: NEUROMOLECULAR MEDICINE. 2013;15(3):458-469
Role of Individual MARK Isoforms in Phosphorylation of Tau at Ser²⁶² in Alzheimer's Disease
Gu GJ; Lund H; Wu D; Blokzijl A; Classon C; von Euler G; Landegren U; Sunnemark D; Kamali-Moghaddam M
Article: BRAIN PATHOLOGY. 2013;23(4):378-389
Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain
Lund H; Cowburn RF; Gustafsson E; Stromberg K; Svensson A; Dahllund L; Malinowsky D; Sunnemark D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;33(3):699-713
Elevated MARK2-Dependent Phosphorylation of Tau in Alzheimer's Disease
Gu GJ; Wu D; Lund H; Sunnemark D; Kvist AJ; Milner R; Eckersley S; Nilsson LNG; Agerman K; Landegren U; Kamali-Moghaddam M
Article: PHYTOTHERAPY RESEARCH. 2011;25(6):851-857
Dietary Quinic Acid Supplied as the Nutritional Supplement AIO + AC-11® leads to Induction of Micromolar Levels of Nicotinamide and Tryptophan in the Urine
Pero RW; Lund H
Article: PHYTOTHERAPY RESEARCH. 2009;23(3):335-346
Antioxidant Metabolism Induced by Quinic Acid. Increased Urinary Excretion of Tryptophan and Nicotinamide
Pero RW; Lund H; Leanderson T
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All other publications

Preprint: BIORXIV. 2024
Regionalized cell and gene signatures govern oesophageal epithelial homeostasis
Grommisch D; Lund H; Eenjes E; Julien A; Göritz C; Harris R; Sandberg R; Hagemann-Jensen M; Genander M
Preprint: BIORXIV. 2023
Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord
Zhu K; Min J-H; Joshua V; Liu Y; Pieber M; Suerth V; Sarlus H; Harris R; Lund H
Preprint: BIORXIV. 2023
A network of CD163⁺macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier
Lund H; Hunt M; Kurtovic Z; Sandor K; Fereydouni N; Julien A; Göritz C; Han J; Zhu K; Harris R; Lampa J; Haglund L; Yaksh T; Svensson C
Preprint: BIORXIV. 2021
Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation
Zhu K; Wang Y; Sarlus H; Geng K; Nutma E; Sun J; Kung S-Y; Bay C; Han J; Lund H; Amor S; Wang J; Zhang X; Kutter C; Guerreiro Cacais AO; Högberg B; Harris R
Preprint: RESEARCH SQUARE. 2020
Sex-Specific Effects of Microglia-Like Cell Engraftment During Experimental Autoimmune Encephalomyelitis
Han J; Zhu K; Zhou K; Hakim R; Sankavaram SR; Blomgren K; Lund H; Zhang X-M; Harris RA
Doctoral thesis: 2018
Regulation of microglia and monocyte function by the cytokine TGF-beta
Lund H
Review: FRONTIERS IN AGING NEUROSCIENCE. 2017;9:234
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies
Lund H; Pieber M; Harris RA

Grants

Cellular and Molecular mapping of the blood nerve barrier during health and disease
Swedish Research Council
1 January 2025 - 31 December 2028

Employments

Assistant Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-2030

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2018

About me

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