Nanomedicine and Spatial Biology – Teixeira Lab

We are interested in understanding the roles of spatial organization in biological processes. To this end, we develop new tools that enable characterization of the spatial organization of biomolecules from nanoscale to single cell to tissue levels. Building on the principles of DNA and protein self-assembly, we develop methods to modulate the nanoscale spatial organization and valency of biomolecules to control membrane receptor functions.

Part of the:

Department of Physiology and Pharmacology

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Publications
Staff and contact

Publications

Selected publications

Article: ACS NANO. 2021;15(2):3441-3452
Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets
Fang T; Alvelid J; Spratt J; Ambrosetti E; Testa I; Teixeira AI
Article: NATURE NANOTECHNOLOGY. 2021;16(1):85-95
A DNA-nanoassembly-based approach to map membrane protein nanoenvironments.
Ambrosetti E; Bernardinelli G; Hoffecker I; Hartmanis L; Kiriako G; de Marco A; Sandberg R; Högberg B; Teixeira AI
Article: NUCLEIC ACIDS RESEARCH. 2020;48(10):5777-5787
Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers
Verheyen T; Fang T; Lindenhofer D; Wang Y; Akopyan K; Lindqvist A; Hogberg B; Teixeira AI
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986
Modeling the transport of nuclear proteins along single skeletal muscle cells
Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
Article: SMALL. 2019;15(1):e1803628
Solution-Controlled Conformational Switching of an Anchored Wireframe DNA Nanostructure
Hoffecker IT; Chen S; Gadin A; Bosco A; Teixeira AI; Hogberg B
Article: MOLECULAR METABOLISM. 2018;7:12-22
Neurturin is a PGC-1 α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation
Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
Article: CELL REPORTS. 2014;8(3):665-670
CtBPs Sense Microenvironmental Oxygen Levels to Regulate Neural Stem Cell State
Dias JM; Ilkhanizadeh S; Karaca E; Duckworth JK; Lundin V; Rosenfeld MG; Ericson J; Hermanson O; Teixeira AI
Article: NATURE METHODS. 2014;11(8):841-846
Spatial control of membrane receptor function using ligand nanocalipers
Shaw A; Lundin V; Petrova E; Fordos F; Benson E; Al-Amin A; Herland A; Blokzijl A; Hogberg B; Teixeira AI
Article: BIOMATERIALS. 2014;35(5):1420-1428
A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons
Zhang D; Pekkanen-Mattila M; Shahsavani MO; Falk A; Teixeira AI; Herland A
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2011;50(52):12529-12533
Electrochemical Control of Growth Factor Presentation To Steer Neural Stem Cell Differentiation
Herland A; Persson KM; Lundin V; Fahlman M; Berggren M; Jager EWH; Teixeira AI

Staff and contact

Group leader

Ana Teixeira
Principal Researcher | Docent
Telephone +46852487979
E-mail ana.teixeira@ki.se

All members of the group

Elena Ambrosetti
Affiliated to Research
E-mail elena.ambrosetti@ki.se
Igor Baars
Postdoctoral Researcher
E-mail igor.baars@ki.se
José Dias
Research Specialist
E-mail jose.dias@ki.se
Enya Engström
Research Specialist
E-mail enya.engstrom@ki.se
Tade Idowu
Phd Student
E-mail tade.idowu@ki.se
Vitaliy Kaminsky
Senior Research Specialist
E-mail vitaly.kaminsky@ki.se
Georges Kiriako
Postdoctoral Researcher
E-mail georges.kiriako@ki.se
Lokesh Patil
Postdoctoral Researcher
E-mail lokesh.patil@ki.se
Ekaterina Petrova
Affiliated to Research
E-mail ekaterina.petrova@ki.se
Margareta Porsmyr-Palmertz
Laboratory Manager
E-mail margareta.porsmyr.palmertz@ki.se
Chayenne Tillack
Affiliated to Research
E-mail chayenne.tillack@ki.se
Tingting Zheng
Postdoctoral Researcher
E-mail tingting.zheng@ki.se