Top Publications MTC

Top Publications by MTC Researchers.

Top publications 2023

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.
Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, Hanke L, Chernyshev M, Narang S, Kim S, Fischbach J, Ekström S, McInerney G, Hällberg BM, Murrell B, Corcoran M, Karlsson Hedestam GB
Immunity 2023 Jan;56(1):193-206.e7

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes.
Corcoran M, Chernyshev M, Mandolesi M, Narang S, Kaduk M, Ye K, Sundling C, Färnert A, Kreslavsky T, Bernhardsson C, Larena M, Jakobsson M, Karlsson Hedestam GB
Immunity 2023 Mar;56(3):635-652.e6

Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages.
Chernyshev M, Sakharkar M, Connor RI, Dugan HL, Sheward DJ, Rappazzo CG, Stålmarck A, Forsell MNE, Wright PF, Corcoran M, Murrell B, Walker LM, Karlsson Hedestam GB
Nat Commun 2023 Apr;14(1):2249

The extracellular matrix - immune microenvironment crosstalk in cancer therapy: challenges and opportunities.
Closset L, Gultekin O, Salehi S, Sarhan D, Lehti K, Gonzalez-Molina J
Matrix Biol 2023 Jul;():

MMP14 expression and collagen remodelling support uterine leiomyosarcoma aggressiveness.
Gonzalez-Molina J, Hahn P, Falcão RM, Gultekin O, Kokaraki G, Zanfagnin V, Braz Petta T, Lehti K, Carlson JW
Mol Oncol 2023 Apr;():

Top Publications 2022

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Moin SM, Boyington JC, Boyoglu-Barnum S, Gillespie RA, Cerutti G, Cheung CS, Cagigi A, Gallagher JR, Brand J, Prabhakaran M, Tsybovsky Y, Stephens T, Fisher BE, Creanga A, Ataca S, Rawi R, Corbett KS, Crank MC, Karlsson Hedestam GB, Gorman J, McDermott AB, Harris AK, Zhou T, Kwong PD, Shapiro L, Mascola JR, Graham BS, Kanekiyo M
Immunity 2022 Dec;55(12):2405-2418.e7

Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Leggat DJ, Cohen KW, Willis JR, Fulp WJ, deCamp AC, Kalyuzhniy O, Cottrell CA, Menis S, Finak G, Ballweber-Fleming L, Srikanth A, Plyler JR, Schiffner T, Liguori A, Rahaman F, Lombardo A, Philiponis V, Whaley RE, Seese A, Brand J, Ruppel AM, Hoyland W, Yates NL, Williams LD, Greene K, Gao H, Mahoney CR, Corcoran MM, Cagigi A, Taylor A, Brown DM, Ambrozak DR, Sincomb T, Hu X, Tingle R, Georgeson E, Eskandarzadeh S, Alavi N, Lu D, Mullen TM, Kubitz M, Groschel B, Maenza J, Kolokythas O, Khati N, Bethony J, Crotty S, Roederer M, Karlsson Hedestam GB, Tomaras GD, Montefiori D, Diemert D, Koup RA, Laufer DS, McElrath MJ, McDermott AB, Schief WR
Science 2022 Dec;378(6623):eadd6502

Chemotherapy as a regulator of extracellular matrix-cell communication: Implications in therapy resistance.
Gonzalez-Molina J, Moyano-Galceran L, Single A, Gultekin O, Alsalhi S, Lehti K
Semin Cancer Biol 2022 Nov;86(Pt 3):224-236

Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment.
Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand H, Magalhaes I
Semin Cancer Biol 2022 Nov;86(Pt 3):207-223

Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells.
Gonzalez-Molina J, Kirchhof KM, Rathod B, Moyano-Galceran L, Calvo-Noriega M, Kokaraki G, Bjørkøy A, Ehnman M, Carlson JW, Lehti K
Adv Sci (Weinh) 2022 Oct;9(28):e2202552

The landscape of mRNA nanomedicine
Xiangang Huang, Na Kong, Xingcai Zhang, Yihai Cao, Robert Langer, Wei Tao
Nature, 2022

Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo.
Du Q, Wu J, Fischer C, Seki T, Jing X, Gao J, He X, Hosaka K, Tong L, Yasue A, Miyake M, Sobajima M, Oyadomari S, Sun X, Yang Y, Zhou Q, Ge M, Tao W, Yao S, Cao Y
Proc Natl Acad Sci U S A 2022

Novel TCF21high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix
Li X, Pan J, Liu T, Yin W, MiaoQ, Zhao Z, Gao Y, Zheng W, Li H, Deng R, Huang D, Qiu S, Zhang Y, Qi Q, Deng L, Huang M, Ming-Kuen Tang P, Cao Y, Chen M, Ye W, Zhang D
GI Cancer, 2022

Evasion of neutralising antibodies by omicron sublineage
Sheward Daniel J , Kim Changil, Fischbach J, Muschiol S, Ehling R A, Björkström N K, Karlsson Hedestam G B, Reddy S T, Albert J, Peacock T P, Murrell B
The Lancet, 2022

Brown-fat-mediated tumour suppression by cold-altered global metabolism.
Seki T, Yang Y, Sun X, Lim S, Xie S, Guo Z, Xiong W, Kuroda M, Sakaue H, Hosaka K, Jing X, Yoshihara M, Qu L, Li X, Chen Y, Cao Y
Nature, 2022

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.
Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sörensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheimand Yihai Cao, Susanne Schlisio.
Nature Metabolism, 2022

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies
Hanke L, Sheward D J, Pankow A, Perez Vidakovics L, Karl V, Kim C, Urgard E, Smith N L, Astorga-Wells J, Ekström S, Coquet J M, McInerney G M, Murell B.
Science Advances, 2022

Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study
ShewardD J, Kim C, Ehling R A, Pankow A, Castro Dopico X, Dyrdak R, Martin D P, Reddy S T, DillnerJ, Karlsson Hedestam G B, Albert J, Murrell B.
The Lancet, 2022

Detection and isolation of airborne SARS-CoV-2 in a hospital setting
Rufino de Sousa N, Steponaviciute L, Margerie L, Nissen K, Kjellin M, Reinius B, Salaneck E, Udekwu K I, Gigliotti Rothfuchs A
Indoor Air 2022

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis.
Chen W, Schilperoort M, Cao Y, Shi J, Tabas I, Tao W
Nat Rev Cardiol, 2022

Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism.
Sun X, He X, Zhang Y, Hosaka K, Andersson P, Wu J, Wu J, Jing X, Du Q, Hui X, Ding B, Guo Z, Hong A, Liu X, Wang Y, Ji Q, Beyaert R, Yang Y, Li Q, Cao Y
Gut, 2022

Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging.
Xu X, Mu L, Li L, Liang J, Zhang S, Jia L, Yang X, Dai Y, Zhang J, Wang Y, Niu S, Xia G, Yang Y, Zhang Y, Cao Y, Zhang H
Sci Adv, 2022

Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer.
Kong N, Zhang R, Wu G, Sui X, Wang J, Kim NY, Blake S, De D, Xie T, Cao Y, Tao W
Proc Natl Acad Sci U S A, 2022

The impact of VEGF on cancer metastasis and systemic disease.
Yang Y, Cao Y
Semin Cancer Biol, 2022

PDGFD switches on stem cell endothelial commitment.
Lu W, Xu P, Deng B, Zhang J, Zhan Y, Lin X, Xu X, Xia Z, Yang X, Zeng X, Huang L, Xie B, Wang C, Wang S, Kuang H, Han X, Mora A, Cao Y, Jiang Q, Li X
Angiogenesis, 2022

Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome.
Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, Liu Y, Plescher M, Rodriguez J, Bedoya-Reina OC, Jannig PR, Valente-Silva P, Yu M, Henriksson MA, Zubarev RA, Smed-Sörensen A, Suzuki CK, Ruas JL, Holmberg J, Larsson C, Christofer Juhlin C, von Kriegsheim A, Cao Y, Schlisio S
Nat Metab 2022 06;4(6):739-758

Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
Li Z, Duan H, Jia Y, Zhao C, Li W, Wang X, Gong Y, Dong C, Ma B, Dou S, Zhang B, Li D, Cao Y, Xie L, Zhou Q, Shi W
J Clin Invest, 2022

CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity.
Liang YY, Bacanu S, Sreekumar L, Ramos AD, Dai L, Michaelis M, Cinatl J, Seki T, Cao Y, Coffill CR, Lane DP, Prabhu N, Nordlund P
Cell Chem Biol, 2022

Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy.
Wang Q, Dou S, Zhang B, Jiang H, Qi X, Duan H, Wang X, Dong C, Zhang BN, Xie L, Cao Y, Zhou Q, Shi W
Mol Ther Nucleic Acids, 2022

Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma.
Yang M, Johnsson P, Bräutigam L, Yang XR, Thrane K, Gao J, Tobin NP, Zhou Y, Yu R, Nagy N, Engström PG, Tuominen R, Eriksson H, Lundeberg J, Tucker MA, Goldstein AM, Egyhazi-Brage S, Zhao J, Cao Y, Höiom V
Genet Med, 2022

A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms.
Ouyang J, Bu Q, Tao N, Chen M, Liu H, Zhou J, Liu J, Deng B, Kong N, Zhang X, Chen T, Cao Y, Tao W
Bioact Mater, 2022

A “spindle and thread” mechanism unblocks p53 translation by modulating N-terminal disorder
Kaldmäe M, Vosselman T, Zhong X, Lama D, Chen G, Saluri M, Kronqvist N, Wei Siau J, Seng Ng A, Ghadessy F J, Sabatier P, Vojtesek B, Sarr M, Sahin C, Österlund N, Ilag L L, Väänänen V A, Sedimbi S, Arsenian-Henriksson M, Zubarev R A, Nilsson L, Koeck P J B, Rising A, Abelein A, Fritz N, Johansson J, Lane D P, Landreh M.
Structure, 2022

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke L, Das H, Sheward D J, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith N L, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen G K, Coquet J M, Hällberg M, Murrell B, McInerney G
Nat Commun, 2022

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates
Castro Dopico X Muschiol S, Grinberg N F, Aleman S, Sheward D J, Hanke L, Ahl M, Vikström L, Forsell M, Coquet J M, McInerney G, Dillner J, Bogdanovic G, Murrell B, Albert J, Wallace C, Karlsson Hedestam G
Clin Transl Immunology, 2022

Top Publications 2021

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles.
Vázquez Bernat N, Corcoran M, Nowak I, Kaduk M, Castro Dopico X, Narang S, Maisonasse P, Dereuddre-Bosquet N, Murrell B, Karlsson Hedestam GB
Immunity 2021 Feb;54(2):355-366.e4

Diversity in immunogenomics: the value and the challenge.
Peng K, Safonova Y, Shugay M, Popejoy AB, Rodriguez OL, Breden F, Brodin P, Burkhardt AM, Bustamante C, Cao-Lormeau VM, Corcoran MM, Duffy D, Fuentes-Guajardo M, Fujita R, Greiff V, Jönsson VD, Liu X, Quintana-Murci L, Rossetti M, Xie J, Yaari G, Zhang W, Abedalthagafi MS, Adekoya KO, Ahmed RA, Chang WC, Gray C, Nakamura Y, Lees WD, Khatri P, Alachkar H, Scheepers C, Watson CT, Karlsson Hedestam GB, Mangul S
Nat Methods 2021 Jun;18(6):588-591

Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.
Aljedani SS, Liban TJ, Tran K, Phad G, Singh S, Dubrovskaya V, Pushparaj P, Martinez-Murillo P, Rodarte J, Mileant A, Mangala Prasad V, Kinzelman R, O'Dell S, Mascola JR, Lee KK, Karlsson Hedestam GB, Wyatt RT, Pancera M
PLoS Pathog 2021 Sep;17(9):e1009543

Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance.
Pietilä EA, Gonzalez-Molina J, Moyano-Galceran L, Jamalzadeh S, Zhang K, Lehtinen L, Turunen SP, Martins TA, Gultekin O, Lamminen T, Kaipio K, Joneborg U, Hynninen J, Hietanen S, Grénman S, Lehtonen R, Hautaniemi S, Carpén O, Carlson JW, Lehti K
Nat Commun 2021 Jun;12(1):3904

Intestinal helminth infection transforms the CD4+ T cell composition of the skin
Classon C H, Li M , Clavero A L, Ma J , Feng X , Tibbitt C A, Stark J M, Cardoso R, Ringqvist E, Boon L, Villablanca E J, Rothfuchs A G, Eidsmo L, Coquet J M, Nylén S
Mucosal Immunology 2021

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.
Gultekin O, Gonzalez-Molina J, Hardell E, Moyano-Galceran L, Mitsios N, Mulder J, Kokaraki G, Isaksson A, Sarhan D, Lehti K, Carlson JW
NPJ Precis Oncol 2021 Nov;5(1):97

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.
Bedoya-Reina OC, Li W, Arceo M, Plescher M, Bullova P, Pui H, Kaucka M, Kharchenko P, Martinsson T, Holmberg J, Adameyko I, Deng Q, Larsson C, Juhlin CC, Kogner P, Schlisio S
Nat Commun, 2021

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles
Vázquez Bernat N, Corcoran M, Nowak I, Kaduk M, Castro Dopico X, Narang S, Maisonasse P, Dereuddre-Bosquet N, Murrell B, Karlsson Hedestam G
Immunity,2021

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice
Szurgot I, Hanke L, Sheward D J, Perez Vidakovics L,Murrell B, McInerney G, Liljeström P
Sci Rep., 2021

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Sheward D J, Mandolesi M, Urgard E, Kim C, Hanke L, Vidakovics L P, Pankow A, Smith N L, Castro Dopico X, McInerney G, Coquet J M, Karlsson Hedestam G, Murrell B
Cell Rep Med., 2021

SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M, Sheward D J, Hanke L, Ma J, Pushparaj P, Perez Vidakovics L, Kim C, Àdori M, Lenart K, Loré K, Castro Dopico X, Coquet J M, McInerney G, Karlsson Hedestam G, Murrell B
Cell Rep Med., 2021

Intestinal helminth infection transforms the CD4+ T cell composition of the skin
Classon C H, Li M, Lerma Clavero A, Ma J, Feng X, Tibbitt C A, Stark J M, Cardoso R, Ringqvist E, Boon L, Villablanca E J, Gigliotti Rothfuchs A, Eidsmo L, Coquet J M, Nylén S.
Mucosal Immunol., 2021

Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation.
He M, Saeed MB, Record J, Keszei M, Gonçalves Pinho L, Vasconcelos-Fontes L, D'Aulerio R, Vieira R, Oliveira MMS, Geyer C, Bohaumilitzky L, Thiemann M, Deordieva E, Buedts L, Matias Lopes JP, Pershin D, Hammarström L, Xia Y, Zhao X, Cunningham-Rundles C, Thrasher AJ, Burns SO, Cotta-de-Almeida V, Liu C, Shcherbina A, Vandenberghe P, Westerberg LS.
J Allergy Clin Immunol., 2021

Single-cell analysis pinpoints distinct populations of cytotoxic CD4⁺ T cells and an IL-10⁺CD109⁺ T_H2 cell population in nasal polyps.
Ma J, Tibbitt CA, Georén SK, Christian M, Murrell B, Cardell LO, Bachert C, Coquet JM.
Sci Immunol., 2021

Dysbiosis of the Human Oral Microbiome During the Menstrual Cycle and Vulnerability to the External Exposures of Smoking and Dietary Sugar.
Bostanci N, Krog MC, Hugerth LW, Bashir Z, Fransson E, Boulund F, Belibasakis GN, Wannerberger K, Engstrand L, Nielsen HS, Schuppe-Koistinen I
Front Cell Infect Microbiol., 2021

Top Publications 2020

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses.
Phad GE, Pushparaj P, Tran K, Dubrovskaya V, Àdori M, Martinez-Murillo P, Vázquez Bernat N, Singh S, Dionne G, O'Dell S, Bhullar K, Narang S, Sorini C, Villablanca EJ, Sundling C, Murrell B, Mascola JR, Shapiro L, Pancera M, Martin M, Corcoran M, Wyatt RT, Karlsson Hedestam GB
J Exp Med 2020 Feb;217(2):

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Shen CH, DeKosky BJ, Guo Y, Xu K, Gu Y, Kilam D, Ko SH, Kong R, Liu K, Louder MK, Ou L, Zhang B, Chao CW, Corcoran MM, Feng E, Huang J, Normandin E, O'Dell S, Ransier A, Rawi R, Sastry M, Schmidt SD, Wang S, Wang Y, Chuang GY, Doria-Rose NA, Lin B, Zhou T, Boritz EA, Connors M, Douek DC, Karlsson Hedestam GB, Sheng Z, Shapiro L, Mascola JR, Kwong PD
Cell Host Microbe 2020 Apr;27(4):531-543.e6

Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity.
Ols S, Yang L, Thompson EA, Pushparaj P, Tran K, Liang F, Lin A, Eriksson B, Karlsson Hedestam GB, Wyatt RT, Loré K
Cell Rep 2020 Mar;30(12):3964-3971.e7

Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
Moyano-Galceran L, Pietilä EA, Turunen SP, Corvigno S, Hjerpe E, Bulanova D, Joneborg U, Alkasalias T, Miki Y, Yashiro M, Chernenko A, Jukonen J, Singh M, Dahlstrand H, Carlson JW, Lehti K
EMBO Mol Med 2020 Apr;12(4):e11177

Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?
Bedoya-Reina OC, Schlisio S
Cancer Cell 2020

Why? - Successful Pseudomonas aeruginosa clones with a focus on clone C.
Lee C, Klockgether J, Fischer S, Trcek J, Tümmler B, Römling U
FEMS Microbiol Rev 2020

An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma.
Record J, Sendel A, Kritikou JS, Kuznetsov NV, Brauner H, He M, Nagy N, Oliveira MMS, Griseti E, Haase CB, Dahlström J, Boddul S, Wermeling F, Thrasher AJ, Liu C, Andersson J, Claesson HE, Winqvist O, Burns SO, Björkholm M, Westerberg LS.
Haematologica 2020

Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways.
Sender V, Hentrich K, Pathak A, Tan Qian Ler A, Embaie BT, Lundström SL, Gaetani M, Bergstrand J, Nakamoto R, Sham LT, Widengren J, Normark S, Henriques-Normark B
Proc Natl Acad Sci U S A 2020

The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism.
Reithuber E, Nannapaneni P, Rzhepishevska O, Lindgren AEG, Ilchenko O, Normark S, Almqvist F, Henriques-Normark B, Mellroth P
mBio 2020

Flame-Made Calcium Phosphate Nanoparticles with High Drug Loading for Delivery of Biologics.
Tsikourkitoudi V, Karlsson J, Merkl P, Loh E, Henriques-Normark B, Sotiriou GA
Molecules 2020

Gradient acoustic focusing of sub-micron particles for separation of bacteria from blood lysate.
Van Assche D, Reithuber E, Qiu W, Laurell T, Henriques-Normark B, Mellroth P, Ohlsson P, Augustsson P
Sci Rep 2020

Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells.
Susanto E, Marin Navarro A, Zhou L, Sundström A, van Bree N, Stantic M, Moslem M, Tailor J, Rietdijk J, Zubillaga V, Hübner JM, Weishaupt H, Wolfsberger J, Alafuzoff I, Nordgren A, Magnaldo T, Siesjö P, Johnsen JI, Kool M, Tammimies K, Darabi A, Swartling FJ, Falk A, Wilhelm M.
Proc Natl Acad Sci U S A 2020

Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo.
He X, Yin X, Wu J, Wickström SL, Duo Y, Du Q, Qin S, Yao S, Jing X, Hosaka K, Wu J, Jensen LD, Lundqvist A, Salter AI, Bräutigam L, Tao W, Chen Y, Kiessling R, Cao Y
Proc Natl Acad Sci U S A 2020

Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors.
Hosaka K, Yang Y, Seki T, Du Q, Jing X, He X, Wu J, Zhang Y, Morikawa H, Nakamura M, Scherzer M, Sun X, Xu Y, Cheng T, Li X, Liu X, Li Q, Liu Y, Hong A, Chen Y, Cao Y
Nat Commun 2020

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM
Nat Commun 2020

GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens.
Rohrbeck L, Adori M, Wang S, He C, Tibbitt CA, Chernyshev M, Sirel M, Ribacke U, Murrell B, Bohlooly-Y M, Karlsson MC, Karlsson Hedestam GB, Coquet JM
Immunol Cell Biol 2020

Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing.
Götte B, Utt A, Fragkoudis R, Merits A, McInerney GM
J Virol 2020

Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.
Mushtaq M, Kovalevska L, Darekar S, Abramsson A, Zetterberg H, Kashuba V, Klein G, Arsenian-Henriksson M, Kashuba E
Proc Natl Acad Sci U S A 2020

p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids.
Marin Navarro A, Pronk RJ, van der Geest AT, Oliynyk G, Nordgren A, Arsenian-Henriksson M, Falk A, Wilhelm M
Cell Death Dis 2020

Successful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids.
Søndergaard JN, Geng K, Sommerauer C, Atanasoai I, Yin X, Kutter C
Commun Biol 2020

TIF-Seq2 disentangles overlapping isoforms in complex human transcriptomes.
Wang J, Li B, Marques S, Steinmetz LM, Wei W, Pelechano V
Nucleic Acids Res 2020

Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease.
Subramanian K, Iovino F, Tsikourkitoudi V, Merkl P, Ahmed S, Berry SB, Aschtgen MS, Svensson M, Bergman P, Sotiriou GA, Henriques-Normark B
EMBO Mol Med 2020

Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions.
Iovino F, Merkl P, Spyrogianni A, Henriques-Normark B, Sotiriou GA
Chem Commun (Camb) 2020

Grad-seq in a Gram-positive bacterium reveals exonucleolytic sRNA activation in competence control.
Hör J, Garriss G, Di Giorgio S, Hack LM, Vanselow JT, Förstner KU, Schlosser A, Henriques-Normark B, Vogel J
EMBO J 2020

The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease.
Iovino F, Nannapaneni P, Henriques-Normark B, Normark S
Mol Microbiol 2020

Integrative discovery of treatments for high-risk neuroblastoma.
Almstedt E, Elgendy R, Hekmati N, Rosén E, Wärn C, Olsen TK, Dyberg C, Doroszko M, Larsson I, Sundström A, Arsenian Henriksson M, Påhlman S, Bexell D, Vanlandewijck M, Kogner P, Jörnsten R, Krona C, Nelander S
Nat Commun 2020

Top Publications 2019

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schön A, Todd JP, Wang S, Wei H, Wu W, , Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell 2019 Jul;178(3):567-584.e19

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Dubrovskaya V, Tran K, Ozorowski G, Guenaga J, Wilson R, Bale S, Cottrell CA, Turner HL, Seabright G, O'Dell S, Torres JL, Yang L, Feng Y, Leaman DP, Vázquez Bernat N, Liban T, Louder M, McKee K, Bailer RT, Movsesyan A, Doria-Rose NA, Pancera M, Karlsson Hedestam GB, Zwick MB, Crispin M, Mascola JR, Ward AB, Wyatt RT
Immunity 2019 Nov;51(5):915-929.e7

A mass spectrometry-based approach to distinguish annular and specific lipid binding to membrane proteins.
Bolla JR, Corey RA, Sahin C, Gault J, Hummer A, Hopper JTS, Lane DP, Drew D, Allison TM, Stansfeld PJ, Robinson CV, Landreh M. A
Angew. Chem. Int. Ed. Engl. 2019

Safety of proton pump inhibitors questioned based on a large randomized trial of patients receiving rivaroxaban or aspirin.
Simin J, Liu Q, Fornes R, Brusselaers N
Gastroenterology 2019

An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Zhang L, Irimia A, He L, Landais E, Rantalainen K, Leaman DP, Vollbrecht T, Stano A, Sands DI, Kim AS; IAVI Protocol G Investigators, Poignard P, Burton DR, Murrell B, Ward AB, Zhu J, Wilson IA, Zwick MB
Nat Commun 2019

Pair Correlation Analysis Maps the Dynamic Two-Dimensional Organization of Natural Killer Cell Receptors at the Synapse.
Hedde PN, Staaf E, Singh SB, Johansson S, Gratton E
ACS Nano 2019

Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast.
Wei W, Hennig BP, Wang J, Zhang Y, Piazza I, Pareja Sanchez Y, Chabbert CD, Adjalley SH, Steinmetz LM, Pelechano V
Genome Res. 2019

Evolutionary analyses of base-pairing interactions in DNA and RNA secondary structures.
Golden M, Murrell B, Martin D, Pybus OG, Hein J
Mol. Biol. Evol. 2019

Microbe-host interplay in atopic dermatitis and psoriasis.
Fyhrquist N, Muirhead G, Prast-Nielsen S, Jeanmougin M, Olah P, Skoog T, Jules-Clement G, Feld M, Barrientos-Somarribas M, Sinkko H, van den Bogaard EH, Zeeuwen PLJM, Rikken G, Schalkwijk J, Niehues H, Däubener W, Eller SK, Alexander H, Pennino D, Suomela S, Tessas I, Lybeck E, Baran AM, Darban H, Gangwar RS, Gerstel U, Jahn K, Karisola P, Yan L, Hansmann B, Katayama S, Meller S, Bylesjö M, Hupé P, Levi-Schaffer F, Greco D, Ranki A, Schröder JM, Barker J, Kere J, Tsoka S, Lauerma A, Soumelis V, Nestle FO, Homey B, Andersson B, Alenius H
Nat Commun 2019

The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations.
Tett A, Huang KD, Asnicar F, Fehlner-Peach H, Pasolli E, Karcher N, Armanini F, Manghi P, Bonham K, Zolfo M, De Filippis F, Magnabosco C, Bonneau R, Lusingu J, Amuasi J, Reinhard K, Rattei T, Boulund F, Engstrand L, Zink A, Collado MC, Littman DR, Eibach D, Ercolini D, Rota-Stabelli O, Huttenhower C, Maixner F, Segata N
Cell Host Microbe 2019

No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population.
Hugerth LW, Andreasson A, Talley NJ, Forsberg AM, Kjellström L, Schmidt PT, Agreus L, Engstrand L.
Gut 2019

HyPhy 2.5 - a customizable platform for evolutionary hypothesis testing using phylogenies.
Kosakovsky Pond SL, Poon AFY, Velazquez R, Weaver S, Hepler NL, Murrell B, Shank SD, Magalis BR, Bouvier D, Nekrutenko A, Wisotsky S, Spielman SJ, Frost SDW, Muse SV
Mol. Biol. Evol. 2019

Long-read amplicon denoising.
Kumar V, Vollbrecht T, Chernyshev M, Mohan S, Hanst B, Bavafa N, Lorenzo A, Kumar N, Ketteringham R, Eren K, Golden M, Oliveira MF, Murrell B
Nucleic Acids Res. 2019

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.
Tengvall K, Huang J, Hellström C, Kammer P, Biström M, Ayoglu B, Lima Bomfim I, Stridh P, Butt J, Brenner N, Michel A, Lundberg K, Padyukov L, Lundberg IE, Svenungsson E, Ernberg I, Olafsson S, Dilthey AT, Hillert J, Alfredsson L, Sundström P, Nilsson P, Waterboer T, Olsson T, Kockum I
Proc. Natl. Acad. Sci. U.S.A. 2019

EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance.
Li S, Rodriguez J, Li W, Bullova P, Fell SM, Surova O, Westerlund I, Topcic D, Bergsland M, Stenman A, Muhr J, Nistér M, Holmberg J, Juhlin CC, Larsson C, von Kriegsheim A, Kaelin WG Jr, Schlisio S
Proc. Natl. Acad. Sci. U.S.A. 2019

Ultrabright and Stable Luminescent Labels for Correlative Cathodoluminescence Electron Microscopy Bioimaging.
Keevend K, Puust L, Kurvits K, Gerken LRH, Starsich FHL, Li JH, Matter MT, Spyrogianni A, Sotiriou GA, Stiefel M, Herrmann IK
Nano Lett. 2019

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schön A, Todd JP, Wang S, Wei H, Wu W; NISC Comparative Sequencing Program, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell 2019

How to lose tumor suppression
David Philip Lane
Science 365 (6453), 539-540 2019

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy.
Uribesalgo I, Hoffmann D, Zhang Y, Kavirayani A, Lazovic J, Berta J, Novatchkova M, Pai TP, Wimmer RA, László V, Schramek D, Karim R, Tortola L, Deswal S, Haas L, Zuber J, Szűcs M, Kuba K, Dome B, Cao Y, Haubner BJ, Penninger JM
EMBO Mol Med 2019

The gut microbiota influences skeletal muscle mass and function in mice.
Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, Cox LM, Selkrig J, Posma JM, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser MJ, Auwerx J, Holmes E, Nicholson J, Wahli W, Pettersson S
Sci Transl Med 2019

Adipocyte and lipid metabolism in cancer drug resistance.
Cao Y
J. Clin. Invest. 2019

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.
Tibbitt CA, Stark JM, Martens L, Ma J, Mold JE, Deswarte K, Oliynyk G, Feng X, Lambrecht BN, De Bleser P, Nylén S, Hammad H, Arsenian Henriksson M, Saeys Y, Coquet JM
Immunity 2019

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.
Götte B, Panas MD, Hellström K, Liu L, Samreen B, Larsson O, Ahola T, McInerney GM
PLoS Pathog. 2019

Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma. Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson & Martin E. Rottenberg. Nature Communications volume 10, Article number: 1823 (2019)

Accumulation of Circulating CCR7+ Natural Killer Cells Marks Melanoma Evolution and Reveals a CCL19-Dependent Metastatic Pathway.
Cristiani CM, Turdo A, Ventura V, Apuzzo T, Capone M, Madonna G, Mallardo D, Garofalo C, Giovannone ED, Grimaldi AM, Tallerico R, Marcenaro E, Pesce S, Del Zotto G, Agosti V, Costanzo FS, Gulletta E, Rizzo A, Moretta A, Karre K, Ascierto PA, Todaro M, Carbone E
Cancer Immunol Res 2019

Luminescent CeO2:Eu3+ nanocrystals for robust in situ H2O2 real-time detection in bacterial cell cultures.
Henning DF, Merkl P, Yun C, Iovino F, Xie L, Mouzourakis E, Moularas C, Deligiannakis Y, Henriques-Normark B, Leifer K, Sotiriou GA
Biosens Bioelectron 2019

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.
Turunen SP, von Nandelstadh P, Öhman T, Gucciardo E, Seashore-Ludlow B, Martins B, Rantanen V, Li H, Höpfner K, Östling P, Varjosalo M, Lehti K
Cell Death Differ. 2019

System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection.
Garcia-Moreno M, Noerenberg M, Ni S, Järvelin AI, González-Almela E, Lenz CE, Bach-Pages M, Cox V, Avolio R, Davis T, Hester S, Sohier TJM, Li B, Heikel G, Michlewski G, Sanz MA, Carrasco L, Ricci EP, Pelechano V, Davis I, Fischer B, Mohammed S, Castello A
Mol. Cell 2019

Multi-faceted inhibition of dendritic cell function by CD4+Foxp3+ regulatory T cells.
Seitz C, Liu S, Klocke K, Joly AL, Czarnewski PV, Tibbitt CA, Parigi SM, Westerberg LS, Coquet JM, Villablanca EJ, Wing K, Andersson J
J. Autoimmun. 2019

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes.
Binzer-Panchal A, Hardell E, Viklund B, Ghaderi M, Bosse T, Nucci MR, Lee CH, Hollfelder N, Corcoran P, Gonzalez-Molina J, Moyano-Galceran L, Bell DA, Schoolmeester JK, Måsbäck A, Kristensen GB, Davidson B, Lehti K, Isaksson A, Carlson JW
Clin. Cancer Res. 2019

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.
Subramanian K, Neill DR, Malak HA, Spelmink L, Khandaker S, Dalla Libera Marchiori G, Dearing E, Kirby A, Yang M, Achour A, Nilvebrant J, Nygren PÅ, Plant L, Kadioglu A, Henriques-Normark B
Nat Microbiol 2019

CXADR-Mediated Formation of an AKT Inhibitory Signalosome at Tight Junctions Controls Epithelial-Mesenchymal Plasticity in Breast Cancer.
Nilchian A, Johansson J, Ghalali A, Asanin ST, Santiago A, Rosencrantz O, Sollerbrant K, Vincent CT, Sund M, Stenius U, Fuxe J
Cancer Res. 2019