Top Publications 2018

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds M, van Leeuwen I, Drummond C, Chu S, Healy A, Popova G, et al
Nat Commun 2018 03;9(1):1107

ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex.
Stantic M, Wolfsberger J, Sakil H, Wilhelm M
Oncogene 2018 Apr;():

CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith S, Polavarapu R, Karmali V, et al
J. Clin. Invest. 2018 Mar;128(3):1106-1124

Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface.
Quintana M, Ch'ng J, Moll K, Zandian A, Nilsson P, Idris Z, et al
Sci Rep 2018 Feb;8(1):3262

Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A.
Staaf E, Hedde P, Bagawath Singh S, Piguet J, Gratton E, Johansson S
Sci Signal 2018 Feb;11(517):

STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis.
Gao Y, Basile J, Classon C, Gavier-Widen D, Yoshimura A, Carow B, et al
PLoS Pathog. 2018 Jan;14(1):e1006809

Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria.
Lee C, Franke K, Kamal S, Kim H, Lünsdorf H, Jäger J, et al
Proc. Natl. Acad. Sci. U.S.A. 2018 Jan;115(2):E273-E282

eradication treatment and the risk of gastric adenocarcinoma in a Western population.
Doorakkers E, Lagergren J, Engstrand L, Brusselaers N
Gut 2018 Jan;():

Mechanisms regulating expansion of CD8+ T cells during HIV-1 infection.
Nasi A, Chiodi F
J. Intern. Med. 2018 Mar;283(3):257-267

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase.
Costeira-Paulo J, Gault J, Popova G, Ladds M, van Leeuwen I, Sarr M, et al
Cell Chem Biol 2018 Mar;25(3):309-317.e4

Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning.
Seki T, Hosaka K, Fischer C, Lim S, Andersson P, Abe M, et al
J. Exp. Med. 2018 Feb;215(2):611-626

Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo.
Parigi S, Czarnewski P, Das S, Steeg C, Brockmann L, Fernandez-Gaitero S, et al
Sci Rep 2018 Jan;8(1):154

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.
Mazzon M, Castro C, Thaa B, Liu L, Mutso M, Liu X, et al
PLoS Pathog. 2018 Jan;14(1):e1006835

-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling.
Dzieran J, Rodriguez Garcia A, Westermark U, Henley A, Eyre Sánchez E, Träger C, et al
Proc. Natl. Acad. Sci. U.S.A. 2018 Feb;115(6):E1229-E1238

Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy.
Qiu M, Wang D, Liang W, Liu L, Zhang Y, Chen X, et al
Proc. Natl. Acad. Sci. U.S.A. 2018 Jan;115(3):501-506

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine.
Hwang L, Phang B, Liew O, Iqbal J, Koh X, Koh X, et al
Cell Rep 2018 Jan;22(1):299-312

Publications from 2017