The EIRA study

Exposure to Occupational Inhalants and the Risk of Developing Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
Liu Q, Song X, Mauro E, Jiang Y, Shchetynsky K, Klareskog L, Alfredsson L, Jiang X
Arthritis Rheumatol 2026 Apr;78(4):830-847

In early rheumatoid arthritis, comorbidities do not explain the increased risk of failure to reach remission in patients with obesity.
Tidblad L, Öberg Sysojev A, Delcoigne B, Klareskog L, Alfredsson L, Askling J, Westerlind H, Saevarsdottir S
RMD Open 2025 Apr;11(2):

Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis.
Sysojev AÖ, Delcoigne B, Frisell T, Alfredsson L, Klareskog L, , Saevarsdottir S, Boman M, Padyukov L, Askling J, Westerlind H
J Intern Med 2025 Jun;297(6):693-701

Revisiting the Link Between HLA-DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non-Shared Epitope Alleles *09 and *15 With High Levels of Anti-Citrullinated Peptide/Protein Antibodies.
Lagutkin D, Panaifo L, Nurul-Aain AF, Israelsson L, Hansson M, Lundberg K, Alfredsson L, Askling J, , Klareskog L, Too CL, Padyukov L
ACR Open Rheumatol 2025 Jan;7(1):e11767

Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis.
Lourido L, Joshua V, Hansson M, Sjöberg R, Pin E, Ruiz-Romero C, Nilsson P, Alfredsson L, Klareskog L, Blanco FJ
Rheumatology (Oxford) 2024 Nov;63(11):3106-3114

Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants.
Sysojev AÖ, Alfredsson L, Klareskog L, , Silberberg GN, Saevarsdottir S, Padyukov L, Magnusson PKE, Askling J, Westerlind H
Arthritis Rheumatol 2024 Sep;76(9):1344-1352

Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis.
Sysojev AÖ, Saevarsdottir S, Diaz-Gallo LM, Silberberg GN, Alfredsson L, Klareskog L, Baecklund E, Björkman L, Kastbom A, Rantapää-Dahlqvist S, Turesson C, Jonsdottir I, Stefansson K, Frisell T, Padyukov L, Askling J, Westerlind H
Rheumatology (Oxford) 2024 May;63(5):1221-1229

In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation.
Pertsinidou E, Saevarsdottir S, Manivel VA, Klareskog L, Alfredsson L, Mathsson-Alm L, Hansson M, Cornillet M, Serre G, Holmdahl R, Skriner K, Jakobsson PJ, Westerlind H, Askling J, Rönnelid J
Ann Rheum Dis 2024 Feb;83(3):277-287

Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis: a study of harmonised Swedish, Danish and Norwegian cohorts.
Westerlind H, Glintborg B, Hammer HB, Saevarsdottir S, Krogh NS, Hetland ML, Hauge EM, Martinez Tejada I, Sexton J, Askling J
RMD Open 2023 Sep;9(3):

Prevention vs treatment of rheumatoid arthritis.
Klareskog L, Alfredsson L
Immunother Adv 2023 ;3(1):ltad016

Disease Activity and Health-Related Quality of Life Among Patients With Rheumatoid Arthritis With Different Alcohol Consumption Habits.
Alfredsson L, Klareskog L, Hedström AK
Arthritis Rheumatol 2023 Jun;75(6):872-878

The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis.
Westerlind H, Kastbom A, Rönnelid J, Hansson M, Alfredsson L, Mathsson-Alm L, Serre G, Cornillet M, Holmdahl R, Skriner K, Bang H, Klareskog L, Saevarsdottir S, Lundberg K, Grönwall C, Askling J
Rheumatology (Oxford) 2023 Jun;62(6):2106-2112

Influence of Smoking on Disease Activity and Quality of Life in Patients With Rheumatoid Arthritis: Results From a Swedish Case-Control Study With Longitudinal Follow-Up.
Alfredsson L, Klareskog L, Hedström AK
Arthritis Care Res (Hoboken) 2023 Jun;75(6):1269-1277

Occupational inhalable agents constitute major risk factors for rheumatoid arthritis, particularly in the context of genetic predisposition and smoking.
Tang B, Liu Q, Ilar A, Wiebert P, Hägg S, Padyukov L, Klareskog L, Alfredsson L, Jiang X
Ann Rheum Dis 2023 Mar;82(3):316-323

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.
Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC, , Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S
Nat Genet 2022 Nov;54(11):1640-1651

Risk of lung cancer in rheumatoid arthritis and in relation to autoantibody positivity and smoking.
Chatzidionysiou K, di Giuseppe D, Soderling J, Catrina A, Askling J
RMD Open 2022 Oct;8(2):

Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis: results from the Swedish EIRA study.
Hedenstierna L, Hedström AK, Klareskog L, Di Giuseppe D, Alfredsson L, Askling J, Ernestam S, Saevarsdottir S, Ljung L
Arthritis Res Ther 2022 Aug;24(1):203

Investigation of the association between coffee and risk of RA-results from the Swedish EIRA study.
Westerlind H, Dukuzimana J, Lu X, Alfredsson L, Klareskog L, Di Giuseppe D
Arthritis Res Ther 2022 Jul;24(1):178

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.
Saevarsdottir S, Stefansdottir L, Sulem P, Thorleifsson G, Ferkingstad E, Rutsdottir G, Glintborg B, Westerlind H, Grondal G, Loft IC, Sorensen SB, Lie BA, Brink M, Ärlestig L, Arnthorsson AO, Baecklund E, Banasik K, Bank S, Bjorkman LI, Ellingsen T, Erikstrup C, Frei O, Gjertsson I, Gudbjartsson DF, Gudjonsson SA, Halldorsson GH, Hendricks O, Hillert J, Hogdall E, Jacobsen S, Jensen DV, Jonsson H, Kastbom A, Kockum I, Kristensen S, Kristjansdottir H, Larsen MH, Linauskas A, Hauge EM, Loft AG, Ludviksson BR, Lund SH, Markusson T, Masson G, Melsted P, Moore KHS, Munk H, Nielsen KR, Norddahl GL, Oddsson A, Olafsdottir TA, Olason PI, Olsson T, Ostrowski SR, Hørslev-Petersen K, Rognvaldsson S, Sanner H, Silberberg GN, Stefansson H, Sørensen E, Sørensen IJ, Turesson C, Bergman T, Alfredsson L, Kvien TK, Brunak S, Steinsson K, Andersen V, Andreassen OA, Rantapää-Dahlqvist S, Hetland ML, Klareskog L, Askling J, Padyukov L, Pedersen OB, Thorsteinsdottir U, Jonsdottir I, Stefansson K, , , 
Ann Rheum Dis 2022 Aug;81(8):1085-1095

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Aetiology.
Sherina N, de Vries C, Kharlamova N, Sippl N, Jiang X, Brynedal B, Kindstedt E, Hansson M, Mathsson-Alm L, Israelsson L, Stålesen R, Saevarsdottir S, Holmdahl R, Hensvold A, Johannsen G, Eriksson K, Sallusto F, Catrina AI, Rönnelid J, Grönwall C, Yucel-Lindberg T, Alfredsson L, Klareskog L, Piccoli L, Malmström V, Amara K, Lundberg K
Front Immunol 2022 ;13():804822

Unmet Needs in Rheumatoid Arthritis: A Subgroup of Patients With High Levels of Pain, Fatigue, and Psychosocial Distress 3 Years After Diagnosis.
Lindqvist J, Alfredsson L, Klareskog L, Lampa J, Westerlind H
ACR Open Rheumatol 2022 Jun;4(6):492-502

Allergic conditions and risk of rheumatoid arthritis: a Swedish case-control study.
Kronzer VL, Westerlind H, Alfredsson L, Crowson CS, Klareskog L, Holmqvist M, Askling J
RMD Open 2022 Feb;8(1):

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study.
Lyne L, Åkerstedt T, Alfredsson L, Lehtonen T, Saevarsdottir S, Klareskog L, Westerlind H
RMD Open 2022 Jan;8(1):

Passive smoking in childhood accelerates RA risk for smokers.
Klareskog L
Nat Rev Rheumatol 2022 Jan;18(1):7-8

Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study.
Westerlind H, Palmqvist I, Saevarsdottir S, Alfredsson L, Klareskog L, Di Giuseppe D
Arthritis Res Ther 2021 Aug;23(1):209

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis.
Grönwall C, Liljefors L, Bang H, Hensvold AH, Hansson M, Mathsson-Alm L, Israelsson L, Joshua V, Svärd A, Stålesen R, Titcombe PJ, Steen J, Piccoli L, Sherina N, Clavel C, Svenungsson E, Gunnarsson I, Saevarsdottir S, Kastbom A, Serre G, Alfredsson L, Malmström V, Rönnelid J, Catrina AI, Lundberg K, Klareskog L
Front Immunol 2021 ;12():627986

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study.
Zhu J, Niu Z, Alfredsson L, Klareskog L, Padyukov L, Jiang X
Arthritis Res Ther 2021 Apr;23(1):108

Rheumatoid arthritis autoantibodies and their association with age and sex.
Pertsinidou E, Manivel VA, Westerlind H, Klareskog L, Alfredsson L, Mathsson-Alm L, Hansson M, Saevarsdottir S, Askling J, Rönnelid J
Clin Exp Rheumatol 2021 ;39(4):879-882

Widespread non-joint pain in early rheumatoid arthritis.
Schelin M, Westerlind H, Lindqvist J, Englid E, Israelsson L, Skillgate E, Klareskog L, Alfredsson L, Lampa J
Scand J Rheumatol 2021 Jul;50(4):271-279

The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study.
Tan LK, Too CL, Diaz-Gallo LM, Wahinuddin S, Lau IS, Heselynn H, Nor-Shuhaila S, Gun SC, Eashwary M, Mohd-Shahrir MS, Ainon MM, Azmillah R, Muhaini O, Shahnaz M, Alfredsson L, Klareskog L, Padyukov L
Arthritis Res Ther 2021 Jan;23(1):46

Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factors: results from the Swedish EIRA study.
Hedenstierna L, Opava CH, Askling J, Jiang X, Ernestam S, Alfredsson L, Klareskog L, Saevarsdottir S
Scand J Rheumatol 2021 May;50(3):178-182

Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking.
Kronzer VL, Westerlind H, Alfredsson L, Crowson CS, Nyberg F, Tornling G, Klareskog L, Holmqvist M, Askling J
Arthritis Rheumatol 2021 Jan;73(1):61-68

Anti-Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid Arthritis.
Westerlind H, Rönnelid J, Hansson M, Alfredsson L, Mathsson-Alm L, Serre G, Cornillet M, Holmdahl R, Jakobsson PJ, Skriner K, Klareskog L, Saevarsdottir S, Askling J
Arthritis Rheumatol 2020 Oct;72(10):1658-1667

Presence of autoantibodies in "seronegative" rheumatoid arthritis associates with classical risk factors and high disease activity.
Reed E, Hedström AK, Hansson M, Mathsson-Alm L, Brynedal B, Saevarsdottir S, Cornillet M, Jakobsson PJ, Holmdahl R, Skriner K, Serre G, Alfredsson L, Rönnelid J, Lundberg K
Arthritis Res Ther 2020 Jul;22(1):170

The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis.
Klareskog L, Rönnelid J, Saevarsdottir S, Padyukov L, Alfredsson L
J Intern Med 2020 May;287(5):514-533

Occupational physical workload and development of anti-collagen type II antibodies in rheumatoid arthritis: results from the Swedish EIRA population-based case-control study.
Zeng P, Pertsinidou E, Brynedal B, Manivel VA, Klareskog L, Mullazehi M, Saevarsdottir S, Bengtsson C, Alfredsson L, Rönnelid J
Clin Exp Rheumatol 2020 ;38(5):1029-1030

A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
Rivera NV, Patasova K, Kullberg S, Diaz-Gallo LM, Iseda T, Bengtsson C, Alfredsson L, Eklund A, Kockum I, Grunewald J, Padyukov L
Sci Rep 2019 Dec;9(1):18633

Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance.
Wang Y, Lloyd KA, Melas I, Zhou D, Thyagarajan R, Lindqvist J, Hansson M, Svärd A, Mathsson-Alm L, Kastbom A, Lundberg K, Klareskog L, Catrina AI, Rapecki S, Malmström V, Grönwall C
Sci Rep 2019 Dec;9(1):19995

Occupational exposure to organic dusts and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study.
Ilar A, Gustavsson P, Wiebert P, Alfredsson L
RMD Open 2019 ;5(2):e001049

Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis: a prospective longitudinal inception cohort study.
Boman A, Brink M, Lundquist A, Hansson M, Mathsson-Alm L, Rönnelid J, Berglin E, Holmdahl R, Skriner K, Serre G, Klareskog L, Rantapää-Dahlqvist S
RMD Open 2019 ;5(2):e000946

Complex Relationships of Smoking, HLA-DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population-Based Case-Control Study.
Hedström AK, Rönnelid J, Klareskog L, Alfredsson L
Arthritis Rheumatol 2019 Sep;71(9):1504-1511

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype.
Terao C, Brynedal B, Chen Z, Jiang X, Westerlind H, Hansson M, Jakobsson PJ, Lundberg K, Skriner K, Serre G, Rönnelid J, Mathsson-Alm L, Brink M, Dahlqvist SR, Padyukov L, Gregersen PK, Barton A, Alfredsson L, Klareskog L, Raychaudhuri S
Am J Hum Genet 2019 Sep;105(3):616-624

Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study.
Ilar A, Klareskog L, Saevarsdottir S, Wiebert P, Askling J, Gustavsson P, Alfredsson L
RMD Open 2019 ;5(2):e000978

Complex Relationships of Smoking, HLA-DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population-Based Case-Control Study.
Hedström AK, Rönnelid J, Klareskog L, Alfredsson L
Arthritis Rheumatol 2019 Sep;71(9):1504-1511

Understanding and Prevention of the Evolution Toward Autoimmune Rheumatoid Arthritis: The New Challenge.
Klareskog L
Clin Ther 2019 Jul;41(7):1232-1234

Interplay between obesity and smoking with regard to RA risk.
Hedström AK, Klareskog L, Alfredsson L
RMD Open 2019 ;5(1):e000856

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Lloyd KA, Wigerblad G, Sahlström P, Garimella MG, Chemin K, Steen J, Titcombe PJ, Marklein B, Zhou D, Stålesen R, Ossipova E, Lundqvist C, Ekwall O, Rönnelid J, Mueller DL, Karlsson MCI, Kaplan MJ, Skriner K, Klareskog L, Wermeling F, Malmström V, Grönwall C
Front Immunol 2018 ;9():3033

Mediterranean diet and risk of rheumatoid arthritis: a population-based case-control study.
Johansson K, Askling J, Alfredsson L, Di Giuseppe D, 
Arthritis Res Ther 2018 Aug;20(1):175

Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis.
Diaz-Gallo LM, Ramsköld D, Shchetynsky K, Folkersen L, Chemin K, Brynedal B, Uebe S, Okada Y, Alfredsson L, Klareskog L, Padyukov L
Ann Rheum Dis 2018 Oct;77(10):1454-1462

Exposure to passive smoking and rheumatoid arthritis risk: results from the Swedish EIRA study.
Hedström AK, Klareskog L, Alfredsson L
Ann Rheum Dis 2018 Jul;77(7):970-972

Occupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study.
Ilar A, Alfredsson L, Wiebert P, Klareskog L, Bengtsson C
Arthritis Care Res (Hoboken) 2018 Apr;70(4):499-509

Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients.
Lourdudoss C, Di Giuseppe D, Wolk A, Westerlind H, Klareskog L, Alfredsson L, van Vollenhoven RF, Lampa J
Arthritis Care Res (Hoboken) 2018 Feb;70(2):205-212

Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case-control study.
Hedström AK, Stawiarz L, Klareskog L, Alfredsson L
Eur J Epidemiol 2018 Apr;33(4):415-423

Anti-cyclic citrullinated peptide antibodies, other common autoantibodies, and smoking as risk factors for lymphoma in patients with rheumatoid arthritis.
Baecklund E, Backlin C, Rönnelid J, Toes R, Huizinga T, Åhlin E, Askling J, Hochberg FH, Klareskog L, Kay J, Smedby KE
Scand J Rheumatol 2018 Jul;47(4):270-275

Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants.
Rönnelid J, Hansson M, Mathsson-Alm L, Cornillet M, Reed E, Jakobsson PJ, Alfredsson L, Holmdahl R, Skriner K, Serre G, Lundberg K, Klareskog L
Ann Rheum Dis 2018 Feb;77(2):203-211

Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis.
Eriksson K, Nise L, Alfredsson L, Catrina AI, Askling J, Lundberg K, Klareskog L, Yucel-Lindberg T
Ann Rheum Dis 2018 Aug;77(8):1236-1238

Amount of smoking, duration of smoking cessation and their interaction with silica exposure in the risk of rheumatoid arthritis among males: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study.
Zeng P, Chen Z, Klareskog L, Alfredsson L, Bengtsson C, Jiang X
Ann Rheum Dis 2018 Aug;77(8):1238-1241

Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology.
Sherina N, Hreggvidsdottir HS, Bengtsson C, Hansson M, Israelsson L, Alfredsson L, Lundberg K
Arthritis Res Ther 2017 Sep;19(1):219

Relationship between shift work and the onset of rheumatoid arthritis.
Hedström AK, Åkerstedt T, Klareskog L, Alfredsson L
RMD Open 2017 ;3(2):e000475

Working in cold environment and risk of developing rheumatoid arthritis: results from the Swedish EIRA case-control study.
Zeng P, Bengtsson C, Klareskog L, Alfredsson L
RMD Open 2017 ;3(2):e000488

Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.
Orellana C, Saevarsdottir S, Klareskog L, Karlson EW, Alfredsson L, Bengtsson C
Ann Rheum Dis 2017 Nov;76(11):1845-1852

IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis.
Lundström SL, Hensvold AH, Rutishauser D, Klareskog L, Ytterberg AJ, Zubarev RA, Catrina AI
Arthritis Res Ther 2017 Aug;19(1):182

Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study.
Lourdudoss C, Wolk A, Nise L, Alfredsson L, Vollenhoven RV
BMJ Open 2017 Jun;7(6):e016154

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis.
Meng W, Zhu Z, Jiang X, Too CL, Uebe S, Jagodic M, Kockum I, Murad S, Ferrucci L, Alfredsson L, Zou H, Klareskog L, Feinberg AP, Ekström TJ, Padyukov L, Liu Y
Arthritis Res Ther 2017 Mar;19(1):71

Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up.
Manivel VA, Mullazehi M, Padyukov L, Westerlind H, Klareskog L, Alfredsson L, Saevarsdottir S, Rönnelid J
Ann Rheum Dis 2017 Sep;76(9):1529-1536

Physical workload is associated with increased risk of rheumatoid arthritis: results from a Swedish population-based case-control study.
Zeng P, Klareskog L, Alfredsson L, Bengtsson C
RMD Open 2017 ;3(1):e000324

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.
Guerreiro-Cacais AO, Norin U, Gyllenberg A, Berglund R, Beyeen AD, , Petit-Teixeira E, Cornélis F, Saoudi A, Fournié GJ, Holmdahl R, Alfredsson L, Klareskog L, Jagodic M, Olsson T, Kockum I, Padyukov L
Genes Immun 2017 Jan;18(1):48-56

A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study.
Jiang X, Askling J, Saevarsdottir S, Padyukov L, Alfredsson L, Viatte S, Frisell T
Arthritis Res Ther 2016 Dec;18(1):288

Differences in the Spectrum of Anti-Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis.
Too CL, Murad S, Hansson M, Alm LM, Dhaliwal JS, Holmdahl R, Jakobsson PJ, Alfredsson L, Klareskog L, Rönnelid J, Padyukov L
Arthritis Rheumatol 2017 Jan;69(1):58-69

Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate.
Altawil R, Saevarsdottir S, Wedrén S, Alfredsson L, Klareskog L, Lampa J
Arthritis Care Res (Hoboken) 2016 Aug;68(8):1061-8

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.
Han B, Pouget JG, Slowikowski K, Stahl E, Lee CH, Diogo D, Hu X, Park YR, Kim E, Gregersen PK, Dahlqvist SR, Worthington J, Martin J, Eyre S, Klareskog L, Huizinga T, Chen WM, Onengut-Gumuscu S, Rich SS, , Wray NR, Raychaudhuri S
Nat Genet 2016 Jul;48(7):803-10

Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study.
Eriksson K, Nise L, Kats A, Luttropp E, Catrina AI, Askling J, Jansson L, Alfredsson L, Klareskog L, Lundberg K, Yucel-Lindberg T
PLoS One 2016 ;11(5):e0155956

High sodium chloride consumption enhances the effects of smoking but does not interact with SGK1 polymorphisms in the development of ACPA-positive status in patients with RA.
Jiang X, Sundström B, Alfredsson L, Klareskog L, Rantapää-Dahlqvist S, Bengtsson C
Ann Rheum Dis 2016 May;75(5):943-6

Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case-control study.
Too CL, Muhamad NA, Ilar A, Padyukov L, Alfredsson L, Klareskog L, Murad S, Bengtsson C, 
Ann Rheum Dis 2016 Jun;75(6):997-1002

Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material.
Pikwer M, Orellana C, Källberg H, Pikwer A, Turesson C, Klareskog L, Alfredsson L, Saevarsdottir S, Bengtsson C
Arthritis Res Ther 2015 Dec;17():358

Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA.
van Heemst J, Hensvold AH, Jiang X, van Steenbergen H, Klareskog L, Huizinga TW, van der Helm-van Mil A, Catrina AI, Toes RE, Lundberg K, van der Woude D
Ann Rheum Dis 2016 Oct;75(10):1891-8

Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register.
Jiang X, Sandberg ME, Saevarsdottir S, Klareskog L, Alfredsson L, Bengtsson C
Arthritis Res Ther 2015 Nov;17():317

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.
Lee SH, Byrne EM, Hultman CM, Kähler A, Vinkhuyzen AA, Ripke S, Andreassen OA, Frisell T, Gusev A, Hu X, Karlsson R, Mantzioris VX, McGrath JJ, Mehta D, Stahl EA, Zhao Q, Kendler KS, Sullivan PF, Price AL, O'Donovan M, Okada Y, Mowry BJ, Raychaudhuri S, Wray NR, , , Byerley W, Cahn W, Cantor RM, Cichon S, Cormican P, Curtis D, Djurovic S, Escott-Price V, Gejman PV, Georgieva L, Giegling I, Hansen TF, Ingason A, Kim Y, Konte B, Lee PH, McIntosh A, McQuillin A, Morris DW, Nöthen MM, O'Dushlaine C, Olincy A, Olsen L, Pato CN, Pato MT, Pickard BS, Posthuma D, Rasmussen HB, Rietschel M, Rujescu D, Schulze TG, Silverman JM, Thirumalai S, Werge T, , Agartz I, Amin F, Azevedo MH, Bass N, Black DW, Blackwood DH, Bruggeman R, Buccola NG, Choudhury K, Cloninger RC, Corvin A, Craddock N, Daly MJ, Datta S, Donohoe GJ, Duan J, Dudbridge F, Fanous A, Freedman R, Freimer NB, Friedl M, Gill M, Gurling H, De Haan L, Hamshere ML, Hartmann AM, Holmans PA, Kahn RS, Keller MC, Kenny E, Kirov GK, Krabbendam L, Krasucki R, Lawrence J, Lencz T, Levinson DF, Lieberman JA, Lin DY, Linszen DH, Magnusson PK, Maier W, Malhotra AK, Mattheisen M, Mattingsdal M, McCarroll SA, Medeiros H, Melle I, Milanova V, Myin-Germeys I, Neale BM, Ophoff RA, Owen MJ, Pimm J, Purcell SM, Puri V, Quested DJ, Rossin L, Ruderfer D, Sanders AR, Shi J, Sklar P, St Clair D, Stroup TS, Van Os J, Visscher PM, Wiersma D, Zammit S, , Bridges SL, Choi HK, Coenen MJ, de Vries N, Dieud P, Greenberg JD, Huizinga TW, Padyukov L, Siminovitch KA, Tak PP, Worthington J, , De Jager PL, Denny JC, Gregersen PK, Klareskog L, Mariette X, Plenge RM, van Laar M, van Riel P
Int J Epidemiol 2015 Oct;44(5):1706-21

Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis.
Kim K, Jiang X, Cui J, Lu B, Costenbader KH, Sparks JA, Bang SY, Lee HS, Okada Y, Raychaudhuri S, Alfredsson L, Bae SC, Klareskog L, Karlson EW
Arthritis Rheumatol 2015 Oct;67(10):2611-23

An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Jiang X, Källberg H, Chen Z, Ärlestig L, Rantapää-Dahlqvist S, Davila S, Klareskog L, Padyukov L, Alfredsson L
Rheumatology (Oxford) 2016 Jan;55(1):149-55

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens.
Fernandes-Cerqueira C, Ossipova E, Gunasekera S, Hansson M, Mathsson L, Catrina AI, Sommarin Y, Klareskog L, Lundberg K, Rönnelid J, Göransson U, Jakobsson PJ
Arthritis Res Ther 2015 Jun;17(1):155

Associations with smoking and shared epitope differ between IgA- and IgG-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis.
Svärd A, Skogh T, Alfredsson L, Ilar A, Klareskog L, Bengtsson C, Kastbom A
Arthritis Rheumatol 2015 May;67(8):2032-7

Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study.
Orellana C, Saevarsdottir S, Klareskog L, Karlson EW, Alfredsson L, Bengtsson C
Eur J Epidemiol 2015 May;30(5):449-57

Gene-gene interaction and RNA splicing profiles of MAP2K4 gene in rheumatoid arthritis.
Shchetynsky K, Protsyuk D, Ronninger M, Diaz-Gallo LM, Klareskog L, Padyukov L
Clin Immunol 2015 May;158(1):19-28

Recent infections are associated with decreased risk of rheumatoid arthritis: a population-based case-control study.
Sandberg ME, Bengtsson C, Klareskog L, Alfredsson L, Saevarsdottir S
Ann Rheum Dis 2015 May;74(5):904-7

To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors?
Jiang X, Frisell T, Askling J, Karlson EW, Klareskog L, Alfredsson L, Källberg H
Arthritis Rheumatol 2015 Feb;67(2):352-62

Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.
Frisell T, Hellgren K, Alfredsson L, Raychaudhuri S, Klareskog L, Askling J
Ann Rheum Dis 2016 Jan;75(1):183-9

Smokeless tobacco (moist snuff) use and the risk of developing rheumatoid arthritis: results from a case-control study.
Jiang X, Alfredsson L, Klareskog L, Bengtsson C
Arthritis Care Res (Hoboken) 2014 Oct;66(10):1582-6

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.
Snir O, Gomez-Cabrero D, Montes A, Perez-Pampin E, Gómez-Reino JJ, Seddighzadeh M, Klich KU, Israelsson L, Ding B, Catrina AI, Holmdahl R, Alfredsson L, Klareskog L, Tegnér J, Gonzalez A, Malmström V, Padyukov L
Arthritis Res Ther 2014 Aug;16(4):414

Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis.
Sandberg ME, Bengtsson C, Källberg H, Wesley A, Klareskog L, Alfredsson L, Saevarsdottir S
Ann Rheum Dis 2014 Nov;73(11):2029-33

Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies.
Jiang X, Trouw LA, van Wesemael TJ, Shi J, Bengtsson C, Källberg H, Malmström V, Israelsson L, Hreggvidsdottir H, Verduijn W, Klareskog L, Alfredsson L, Huizinga TW, Toes RE, Lundberg K, van der Woude D
Ann Rheum Dis 2014 Oct;73(10):1761-8

Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history.
Sparks JA, Chen CY, Jiang X, Askling J, Hiraki LT, Malspeis S, Klareskog L, Alfredsson L, Costenbader KH, Karlson EW
Ann Rheum Dis 2015 Aug;74(8):1522-9

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.
Han B, Diogo D, Eyre S, Kallberg H, Zhernakova A, Bowes J, Padyukov L, Okada Y, González-Gay MA, Rantapää-Dahlqvist S, Martin J, Huizinga TW, Plenge RM, Worthington J, Gregersen PK, Klareskog L, de Bakker PI, Raychaudhuri S
Am J Hum Genet 2014 Apr;94(4):522-32

GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease.
Liu Y, Li X, Aryee MJ, Ekström TJ, Padyukov L, Klareskog L, Vandiver A, Moore AZ, Tanaka T, Ferrucci L, Fallin MD, Feinberg AP
Am J Hum Genet 2014 Apr;94(4):485-95

Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease.
Sandberg ME, Wedrén S, Klareskog L, Lundberg IE, Opava CH, Alfredsson L, Saevarsdottir S
Ann Rheum Dis 2014 Aug;73(8):1541-4

Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study.
Yahya A, Bengtsson C, Larsson P, Too CL, Mustafa AN, Abdullah NA, Muhamad NA, Klareskog L, Murad S, Alfredsson L
Mod Rheumatol 2014 Mar;24(2):271-4

The influence of polygenic risk scores on heritability of anti-CCP level in RA.
Cui J, Taylor KE, Lee YC, Källberg H, Weinblatt ME, Coblyn JS, Klareskog L, Criswell LA, Gregersen PK, Shadick NA, Plenge RM, Karlson EW
Genes Immun 2014 Mar;15(2):107-14

Genetics of rheumatoid arthritis contributes to biology and drug discovery.
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, , , Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM
Nature 2014 Feb;506(7488):376-81

Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.
Wagner CA, Sokolove J, Lahey LJ, Bengtsson C, Saevarsdottir S, Alfredsson L, Delanoy M, Lindstrom TM, Walker RP, Bromberg R, Chandra PE, Binder SR, Klareskog L, Robinson WH
Ann Rheum Dis 2015 Mar;74(3):579-86

Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age.
Frisell T, Holmqvist M, Källberg H, Klareskog L, Alfredsson L, Askling J
Arthritis Rheum 2013 Nov;65(11):2773-82

Parity and the risk of developing rheumatoid arthritis: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis study.
Orellana C, Wedrén S, Källberg H, Holmqvist M, Karlson EW, Alfredsson L, Bengtsson C, 
Ann Rheum Dis 2014 Apr;73(4):752-5

Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis.
Karlson EW, Ding B, Keenan BT, Liao K, Costenbader KH, Klareskog L, Alfredsson L, Chibnik LB
Arthritis Care Res (Hoboken) 2013 Jul;65(7):1147-56

Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond.
Klareskog L, Lundberg K, Malmström V
Adv Immunol 2013 ;118():129-58

Silica exposure is associated with an increased risk of developing ACPA-positive rheumatoid arthritis in an Asian population: evidence from the Malaysian MyEIRA case-control study.
Yahya A, Bengtsson C, Larsson P, Too CL, Mustafa AN, Abdullah NA, Muhamad NA, Klareskog L, Murad S, Alfredsson L
Mod Rheumatol 2013 Apr;():

Regional differences regarding risk of developing rheumatoid arthritis in Stockholm County, Sweden: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study.
Källberg H, Vieira V, Holmqvist M, Hart JE, Costenbader KH, Bengtsson C, Klareskog L, Karlson EW, Alfredsson L
Scand J Rheumatol 2013 ;42(5):337-43

Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women.
Di Giuseppe D, Orsini N, Alfredsson L, Askling J, Wolk A
Arthritis Res Ther 2013 Apr;15(2):R56

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.
Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, Reinius L, Acevedo N, Taub M, Ronninger M, Shchetynsky K, Scheynius A, Kere J, Alfredsson L, Klareskog L, Ekström TJ, Feinberg AP
Nat Biotechnol 2013 Feb;31(2):142-7

Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis.
Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, Alfredsson L, , , Sunyaev S, Martin J, Zhernakova A, Bowes J, Eyre S, Siminovitch KA, Gregersen PK, Worthington J, Klareskog L, Padyukov L, Raychaudhuri S, Plenge RM
Am J Hum Genet 2013 Jan;92(1):15-27

Association between body mass index and anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis: results from a population-based case-control study.
Wesley A, Bengtsson C, Elkan AC, Klareskog L, Alfredsson L, Wedrén S, 
Arthritis Care Res (Hoboken) 2013 Jan;65(1):107-12

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.
Too CL, Murad S, Dhaliwal JS, Larsson P, Jiang X, Ding B, Alfredsson L, Klareskog L, Padyukov L
Arthritis Res Ther 2012 Nov;14(6):R250

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes RE, Huizinga TW, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, de Bakker PI, Davila S, Khor CC, Heng KK, Andrews R, Edkins S, Hunt SE, Langford C, Symmons D, , , Concannon P, Onengut-Gumuscu S, Rich SS, Deloukas P, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlsetig L, Martin J, Rantapää-Dahlqvist S, Plenge RM, Raychaudhuri S, Klareskog L, Gregersen PK, Worthington J
Nat Genet 2012 Dec;44(12):1336-40

Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study.
Hart JE, Källberg H, Laden F, Bellander T, Costenbader KH, Holmqvist M, Klareskog L, Alfredsson L, Karlson EW
Ann Rheum Dis 2013 Jun;72(6):888-94

Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.
Seddighzadeh M, Gonzalez A, Ding B, Ferreiro-Iglesias A, Gomez-Reino JJ, , Klareskog L, Alfredsson L, Dunussi-Joannopoulos K, Clark JD, Padyukov L
J Rheumatol 2012 Aug;39(8):1509-16

Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis.
Laki J, Lundström E, Snir O, Rönnelid J, Ganji I, Catrina AI, Bengtsson C, Saevarsdottir S, Wick MC, Alfredsson L, Klareskog L, Padyukov L
Arthritis Rheum 2012 Jul;64(7):2078-84

Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA).
Too CL, Yahya A, Murad S, Dhaliwal JS, Larsson PT, Muhamad NA, Abdullah NA, Mustafa AN, Klareskog L, Alfredsson L, Padyukov L, Bengtsson C, 
Arthritis Res Ther 2012 Apr;14(2):R89

CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations.
Eike MC, Skinningsrud B, Ronninger M, Stormyr A, Kvien TK, Joner G, Njølstad PR, Førre O, Flatø B, Alfredsson L, Padyukov L, Undlien DE, Lie BA
Genes Immun 2012 Jul;13(5):431-6

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile.
Lundberg K, Bengtsson C, Kharlamova N, Reed E, Jiang X, Kallberg H, Pollak-Dorocic I, Israelsson L, Kessel C, Padyukov L, Holmdahl R, Alfredsson L, Klareskog L
Ann Rheum Dis 2013 May;72(5):652-8

Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis.
Ronninger M, Seddighzadeh M, Eike MC, Plant D, Daha NA, Skinningsrud B, Worthington J, Kvien TK, Toes RE, Lie BA, Alfredsson L, Padyukov L
PLoS One 2012 ;7(3):e32861

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA, , , Kathiresan S, Wijmenga C, Gregersen PK, Alfredsson L, Siminovitch KA, Worthington J, de Bakker PI, Raychaudhuri S, Plenge RM
Nat Genet 2012 Mar;44(5):483-9

Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study.
Sverdrup BM, Källberg H, Klareskog L, Alfredsson L, 
Arthritis Res Ther 2012 Feb;14(1):R41

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, Alfredsson L, Padyukov L, Klareskog L, Worthington J, Siminovitch KA, Bae SC, Plenge RM, Gregersen PK, de Bakker PI
Nat Genet 2012 Jan;44(3):291-6

Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.
Dervieux T, Wessels JA, Kremer JM, Padyukov L, Seddighzadeh M, Saevarsdottir S, van Vollenhoven RF, Klareskog L, Huizinga TW, Guchelaar HJ
Pharmacogenet Genomics 2012 Jan;22(1):1-9

Smoking is associated with an increased risk of developing ACPA-positive but not ACPA-negative rheumatoid arthritis in Asian populations: evidence from the Malaysian MyEIRA case-control study.
Yahya A, Bengtsson C, Lai TC, Larsson PT, Mustafa AN, Abdullah NA, Muhamad N, Hussein H, Klareskog L, Alfredsson L, Murad S
Mod Rheumatol 2012 Aug;22(4):524-31

The genetic structure of the Swedish population.
Humphreys K, Grankvist A, Leu M, Hall P, Liu J, Ripatti S, Rehnström K, Groop L, Klareskog L, Ding B, Grönberg H, Xu J, Pedersen NL, Lichtenstein P, Mattingsdal M, Andreassen OA, O'Dushlaine C, Purcell SM, Sklar P, Sullivan PF, Hultman CM, Palmgren J, Magnusson PK
PLoS One 2011 ;6(8):e22547

GEIRA: gene-environment and gene-gene interaction research application.
Ding B, Källberg H, Klareskog L, Padyukov L, Alfredsson L
Eur J Epidemiol 2011 Jul;26(7):557-61

Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers.
Saevarsdottir S, Ding B, Steinsson K, Grondal G, Valdimarsson H, Alfredsson L, Klareskog L, Padyukov L
Arthritis Res Ther 2011 Apr;13(2):R65

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis.
Korotkova M, Daha NA, Seddighzadeh M, Ding B, Catrina AI, Lindblad S, Huizinga TW, Toes RE, Alfredsson L, Klareskog L, Jakobsson PJ, Padyukov L
Eur J Hum Genet 2011 Aug;19(8):908-14

Effects of GSTM1 in rheumatoid arthritis; results from the Swedish EIRA study.
Lundström E, Hartshorne T, Li K, Lindblad S, Wick MC, Bengtsson C, Alfredsson L, Klareskog L, Padyukov L
PLoS One 2011 Mar;6(3):e17880

Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Register cohorts.
Saevarsdottir S, Wedrén S, Seddighzadeh M, Bengtsson C, Wesley A, Lindblad S, Askling J, Alfredsson L, Klareskog L
Arthritis Rheum 2011 Jan;63(1):26-36

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome.
Coenen MJ, Enevold C, Barrera P, Schijvenaars MM, Toonen EJ, Scheffer H, Padyukov L, Kastbom A, Klareskog L, Barton A, Kievit W, Rood MJ, Jansen TL, Swinkels D, van Riel PL, Franke B, Bendtzen K, Radstake TR
PLoS One 2010 Dec;5(12):e14326

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Padyukov L, Seielstad M, Ong RT, Ding B, Rönnelid J, Seddighzadeh M, Alfredsson L, Klareskog L, 
Ann Rheum Dis 2011 Feb;70(2):259-65

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke.
Källberg H, Ding B, Padyukov L, Bengtsson C, Rönnelid J, Klareskog L, Alfredsson L, 
Ann Rheum Dis 2011 Mar;70(3):508-11

Prevention of autoimmune rheumatic disease: state of the art and future perspectives.
Klareskog L, Gregersen PK, Huizinga TW
Ann Rheum Dis 2010 Dec;69(12):2062-6

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
Ferreira RC, Pan-Hammarström Q, Graham RR, Gateva V, Fontán G, Lee AT, Ortmann W, Urcelay E, Fernández-Arquero M, Núñez C, Jorgensen G, Ludviksson BR, Koskinen S, Haimila K, Clark HF, Klareskog L, Gregersen PK, Behrens TW, Hammarström L
Nat Genet 2010 Sep;42(9):777-80

Common vaccinations among adults do not increase the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.
Bengtsson C, Kapetanovic MC, Källberg H, Sverdrup B, Nordmark B, Klareskog L, Alfredsson L, 
Ann Rheum Dis 2010 Oct;69(10):1831-3

Non-participation in EIRA: a population-based case-control study of rheumatoid arthritis.
Bengtsson C, Berglund A, Serra ML, Nise L, Nordmark B, Klareskog L, Alfredsson L, Eira Study Group 
Scand J Rheumatol 2010 Aug;39(4):344-6

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM
Arthritis Rheum 2010 Jul;62(7):1849-61

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, , Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, , Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
Nat Genet 2010 Jun;42(6):508-14

Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations.
van der Woude D, Lie BA, Lundström E, Balsa A, Feitsma AL, Houwing-Duistermaat JJ, Verduijn W, Nordang GB, Alfredsson L, Klareskog L, Pascual-Salcedo D, Gonzalez-Gay MA, Lopez-Nevot MA, Valero F, Roep BO, Huizinga TW, Kvien TK, Martín J, Padyukov L, de Vries RR, Toes RE
Arthritis Rheum 2010 May;62(5):1236-45

Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
Ann Rheum Dis 2010 Jun;69(6):1077-85

Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis.
D'Amato M, Zucchelli M, Seddighzadeh M, Anedda F, Lindblad S, Kere J, Alfredsson L, Klareskog L, Padyukov L
PLoS One 2010 Feb;5(2):e9315

Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.
Seddighzadeh M, Korotkova M, Källberg H, Ding B, Daha N, Kurreeman FA, Toes RE, Huizinga TW, Catrina AI, Alfredsson L, Klareskog L, Padyukov L
Eur J Hum Genet 2010 Jul;18(7):821-6

Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis.
Stolt P, Yahya A, Bengtsson C, Källberg H, Rönnelid J, Lundberg I, Klareskog L, Alfredsson L, 
Ann Rheum Dis 2010 Jun;69(6):1072-6

Patients' conceptions of the cause of their rheumatoid arthritis: a qualitative study.
Bergsten U, Bergman S, Fridlund B, Alfredsson L, Berglund A, Petersson IF, Arvidsson B, 
Musculoskeletal Care 2009 Dec;7(4):243-55

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, , Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, , Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
Nat Genet 2009 Dec;41(12):1313-8

Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
Mahdi H, Fisher BA, Källberg H, Plant D, Malmström V, Rönnelid J, Charles P, Ding B, Alfredsson L, Padyukov L, Symmons DP, Venables PJ, Klareskog L, Lundberg K
Nat Genet 2009 Dec;41(12):1319-24

Dietary fish and fish oil and the risk of rheumatoid arthritis.
Rosell M, Wesley AM, Rydin K, Klareskog L, Alfredsson L, 
Epidemiology 2009 Nov;20(6):896-901

No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts.
Holmqvist ME, Wedrén S, Jacobsson LT, Klareskog L, Nyberg F, Rantapää-Dahlqvist S, Alfredsson L, Askling J
Arthritis Rheum 2009 Oct;60(10):2861-9

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important.
Lundström E, Källberg H, Alfredsson L, Klareskog L, Padyukov L
Arthritis Rheum 2009 Jun;60(6):1597-603

Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis.
Hueber W, Tomooka BH, Batliwalla F, Li W, Monach PA, Tibshirani RJ, Van Vollenhoven RF, Lampa J, Saito K, Tanaka Y, Genovese MC, Klareskog L, Gregersen PK, Robinson WH
Arthritis Res Ther 2009 ;11(3):R76

The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility.
Lee YC, Raychaudhuri S, Cui J, De Vivo I, Ding B, Alfredsson L, Padyukov L, Costenbader KH, Seielstad M, Graham RR, Klareskog L, Gregersen PK, Plenge RM, Karlson EW
Arthritis Rheum 2009 May;60(5):1250-4

Environmental influences on risk for rheumatoid arthritis.
Liao KP, Alfredsson L, Karlson EW
Curr Opin Rheumatol 2009 May;21(3):279-83

Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
Lundström E, Källberg H, Smolnikova M, Ding B, Rönnelid J, Alfredsson L, Klareskog L, Padyukov L
Arthritis Rheum 2009 Apr;60(4):924-30

Psychosocial stress at work and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.
Bengtsson C, Theorell T, Klareskog L, Alfredsson L
Psychother Psychosom 2009 ;78(3):193-4

Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.
Liao KP, Gunnarsson M, Källberg H, Ding B, Plenge RM, Padyukov L, Karlson EW, Klareskog L, Askling J, Alfredsson L
Arthritis Rheum 2009 Mar;60(3):653-60

On the origins of complex immune-mediated disease: the example of rheumatoid arthritis.
Klareskog L, Wedrén S, Alfredsson L
J Mol Med (Berl) 2009 Apr;87(4):357-62

Rheumatoid arthritis.
Klareskog L, Catrina AI, Paget S
Lancet 2009 Feb;373(9664):659-72

Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
Ding B, Padyukov L, Lundström E, Seielstad M, Plenge RM, Oksenberg JR, Gregersen PK, Alfredsson L, Klareskog L
Arthritis Rheum 2009 Jan;60(1):30-8

Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
Nat Genet 2008 Oct;40(10):1216-23

Alcohol consumption is associated with decreased risk of rheumatoid arthritis: results from two Scandinavian case-control studies.
Källberg H, Jacobsen S, Bengtsson C, Pedersen M, Padyukov L, Garred P, Frisch M, Karlson EW, Klareskog L, Alfredsson L
Ann Rheum Dis 2009 Feb;68(2):222-7

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D
Nat Genet 2007 Dec;39(12):1477-82

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, de Bakker PI, Le JM, Lee HS, Batliwalla F, Li W, Masters SL, Booty MG, Carulli JP, Padyukov L, Alfredsson L, Klareskog L, Chen WV, Amos CI, Criswell LA, Seldin MF, Kastner DL, Gregersen PK
N Engl J Med 2007 Sep;357(10):977-86

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK
N Engl J Med 2007 Sep;357(12):1199-209

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.
Olsson LM, Lindqvist AK, Källberg H, Padyukov L, Burkhardt H, Alfredsson L, Klareskog L, Holmdahl R
Arthritis Res Ther 2007 ;9(5):R98

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, Alfredsson L, Toes R, Rönnelid J, Klareskog L, Huizinga TW, Alm G, Syvänen AC, Rönnblom L
Arthritis Rheum 2007 Jul;56(7):2202-10

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH, Toes RE, Huizinga TW, Klareskog L, Alfredsson L, 
Am J Hum Genet 2007 May;80(5):867-75

Genes, environment and immunity in the development of rheumatoid arthritis.
Klareskog L, Padyukov L, Rönnelid J, Alfredsson L
Curr Opin Immunol 2006 Dec;18(6):650-5

A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J, Rönnelid J, Harris HE, Ulfgren AK, Rantapää-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L
Arthritis Rheum 2006 Jan;54(1):38-46

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD
Am J Hum Genet 2005 Dec;77(6):1044-60

Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study.
Sverdrup B, Källberg H, Bengtsson C, Lundberg I, Padyukov L, Alfredsson L, Klareskog L, 
Arthritis Res Ther 2005 ;7(6):R1296-303

Socioeconomic status and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.
Bengtsson C, Nordmark B, Klareskog L, Lundberg I, Alfredsson L, 
Ann Rheum Dis 2005 Nov;64(11):1588-94

What precedes development of rheumatoid arthritis?
Klareskog L, Alfredsson L, Rantapää-Dahlqvist S, Berglin E, Stolt P, Padyukov L
Ann Rheum Dis 2004 Nov;63 Suppl 2(Suppl 2):ii28-ii31

Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study.
Stolt P, Källberg H, Lundberg I, Sjögren B, Klareskog L, Alfredsson L, 
Ann Rheum Dis 2005 Apr;64(4):582-6

Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women.
Padyukov L, Hytönen AM, Smolnikova M, Hahn-Zoric M, Nilsson N, Hanson LA, Tarkowski A, Klareskog L
J Rheumatol 2004 Mar;31(3):422-5

Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases.
Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L, 
Ann Rheum Dis 2003 Sep;62(9):835-41

Genes and environment in arthritis: can RA be prevented?
Klareskog L, Lorentzen J, Padyukov L, Alfredsson L
Arthritis Res 2002 ;4 Suppl 3(Suppl 3):S31-6

• Johan Askling, professor and principal investigator.
• Lars Klareskog, professor.
• Lars Alfredsson, professor.

• Caroline Öfverberg Colliander, project coordinator.
• Edit Ekström, project coordinator.
• Johanna Hellgren, project assistant.
• Marina Dehara, database administrator.