Division of Immunology- about us
The research at the division of Immunology focuses on understand the basic physiology of immune system development and deciphering pathogenic mechanisms of immune related disorders including infections, immunodeficiency, autoimmunity, atopic disease and cancers. With this knowledge we aim to translate our findings to new diagnostics markers, preventive vaccines and targeted therapeutic modalities.
Under typical physiological circumstances, the immune system is a carefully control network that can keep the balance of immunological homeostasis. The goal of many of our project is to investigate, early and terminal development of immune system specially B cells with antigen/allergen/pathogens challenges, to understand certain appropriate reactions launched with the intention of reestablishing homeostasis. Under some genetic and environmental conditions, the immune equilibrium is broken, and host responses either under- or overreact. Using large-scale unique patients' registries, advanced technologies and comprehensive in-vivo and in-vitro experimental assays we investigate condition where the immune system may be ineffective or unresponsive, which leads to severe unusual, recurrent infections or unchecked proliferation of the cancer cells (mainly lymphoma). On the other hand, we also are interested in evaluation of immune dysregulation and over reactivations, which can cause pathology like autoimmunity/autoinflammation (mainly rheumatoid arthritis) and atopic disorders. There are several diagnostic measurements and pharmacological treatments that have been proposed by both groups with the goal of treating or preventing such immunological diseases and reestablishing immune balance between tolerance and immunogenicity.