Past Master thesis projects

Toxicology is a broad subject which allows for you to choose your Master thesis project based on your interest(s)! Thanks to Karolinska Institutet's good reputation and agreements with specific universities, the project can be performed all over the world.

Potential projects with a toxicological profile are usually presented during the spring on semester 2. Projects can also be found at various websites at KI and other universities and the students are encouraged to make their own contacts, e.g. teachers at previous courses. Projects may be performed at KI and other internationally recognized universities, pharmaceutical, chemical or consultancy companies or governmental authorities/agencies.

The project can be either an experimental, epidemiological or a literature-based research project or a risk assessment-related project and are usually 37.5 credits.

Here you can read some thoughts from Jiehyun Choi, our former digital ambassador, on how to find the perfect project ►.

Below is a list of some of the projects performed recently.

  • A new in vitro assay to determine the skin sensitizing potency of chemicals with ATX and IL-1b as potential markers @ Karolinska Institutet
  • A systematic in vitro lung health risk and toxicity assessment for electronic cigarettes using ALI-3D models @ Karolinska Institutet
  • Data extraction and Benchmark Dose Modeling of mycotoxin toxicity data in farm animals @ EFSA & University of Parma, Italy
  • Description of patient characteristics and long-term treatment patterns in stable CAD and PAD patients following index CAD or PAD event @ Bayer, Sweden
  • Development and evaluation of an Adverse Outcome Pathway (AOP) for hyperactivity @ Karolinska Institutet and RIVM, Utrecht, Netherlands. 
  • Development of a novel 3D hepatic culture system for assessment of hepatotoxicity induced by gold nanoparticles @ Trinity College Dublin, Irland
  • Development of an immunocompetent human airway co-culture model to investigate adverse drug interactions in the lung @ AstraZeneca, Sweden
  • Effects of cysteine knot toxins on a voltage-gated potassium channel @ Linköping University
  • Elucidating the effects of AMP kinase deficiency in the presence of paraquat-induced toxicity in Drosophila models of Parkinson’s disease @ National University of Singapore
  • Evaluation of human hepatic spheroids as an in vitro model for non-alcoholic steatohepatitis (NASH) @ Karolinska Institutet
  • Evidence-based evaluation of endocrine-disrupting properties, based on European Commission’s scientific criteria: Silver nanoparticles have the ability to disrupt male testicular steroidogenesis and spermatogenesis @ Karolinska Institutet & Swedish Chemicals Agency
  • Exposure to environmental phthalates during preschool age and obesity from children to young adulthood @ Karolinska Institutet
  • In vitro anti tumoral effects of chemo and target therapy on human papillomavirus positive and negative head and neck cancer cell lines @ Karolinska Institutet
  • Metabolic impact of a low-dose mixture of common pollutants in female mice: intestinal outcome of a one-generationstudy @ INSERM, France
  • Pathophysiological role of endogenous and exogenous factors in adipocytes @ Osaka University, Japan
  • Setup of an early screening assay for toxicity using high-content imaging of markers for drug-induced oxidative stress in HepG2 cells @ AstraZeneca, Sweden
  • Synergistic cytotoxic effects of MTH1 inhibitor (TH1579) in combination with mitotic inhibitors (vincristine or vinblastine) in prostate cancer cells @ Karolinska Institutet

A more complete list of projects can be found here►.