Master theses at the Toxicology Programme

Projects performed at Swedish or international universities:

Projects at Karolinska Institutet were performed at several different departments. 

• A new in vitro assay to determine the skin sensitizing potency of chemicals with ATX and IL-1b as potential markers @ Karolinska Institutet
• A systematic in vitro lung health risk and toxicity assessment for electronic cigarettes using ALI-3D models @ Karolinska Institutet
• A toxicokinetic model for Zebrafish (Danio rerio) embryo: understanding the influence of exposure systems for different chemicals @ Karolinska Institutet
• All that glitters is not silver – Toxicity of silver nanoparticles in normal human bronchial cells and macrophages @ Karolinska Institutet
• Analysis of DNA methylation induced by prenatal exposure to an EDC mixture (Mixture N1) @ Uppsala University
• An evaluation of air liquid interface-3D model of human airway mucosa for diacetyl exposure mediated pulmonary toxicity @ Karolinska Institutet
• Analysis of essential and non-essential trace elements in commercial dog foods and canine blood @ Karolinska Institutet
• Assessing the sufficiency of the OEL document in protecting against reproductive and developmental toxicity @ Karolinska Institutet
• Assessment of biomass smoke induced pulmonary toxicity and the protective role of magnolol using bronchial and alveolar mucosa models @ Karolinska Institutet
• Assessment of gases and diesel exhaust particles present in air pollution, induced pulmonary toxicity using multi-cellular lung mucosa models @ Karolinska Institutet
• Assessment of increased susceptibility to COVID-19 following exposure to tobacco smoke extract using lung mucosa models @ Karolinska Institutet
• Assessment of pulmonary toxicity following both single and repeated exposure of Diesel Exhaust Particles and gases (NO2 & SO2) using Air-Liquid Interface model @ Karolinska Institutet
• Assessment of short and frequent skin contact with nickel with regards to allergy risk @ Karolinska Institutet
• Autotaxin as a valuable player for future in vitro testing of skin sensitizers @ Karolinska Institutet
• Benchmark dose analysis for safety assessment in pharmaceutical development @ Karolinska Institutet
• Bioinformatics analysis to reveal effects of cadmium on DNA methylation in the placenta @ Karolinska Institutet
• Biomarkers in head and neck cancer – a wiki to facilitate personalized and predictive medicine @ Karolinska Institutet
• Can Cadmium exposure lead to the neurodevelopmental outcome of ADHD? @ Karolinska Institutet
• Central dogma of proteomics: application to bacteria treated with antimicrobial agents @ Karolinska Institutet
• Clinical role of antibodies against malondialdehyde (anti-MDA) in Rheumatoid Arthritis and Systemic Lupus Erythematosus @ Karolinska Institutet
• Cobalt in vitro skin absorption in different skin models @ Karolinska Institutet
• Comprehensive chemical proteomics for identification of protein targets and action mechanisms of approved and prospective COVID-19 drugs in human lung and immune cancer cells @ Karolinska Institutet
• Connecting epigenetic changes induced by the endocrine disruptor bisphenol A with psychiatric disorders @ Karolinska Institutet
• Correlating epigenetic patterns in human samples to exposure and health outcomes @ Karolinska Institutet
• Cytostatics Conditioning Prior to MSLN CAR T Cell Therapy for The Treatment of Advanced Ovarian Cancer @ Karolinska Institutet
• Determining differential sex responses in pro-oncogenic signalling pathways after cigarette smoke extract exposure @ Trinity College, Dublin, Ireland
• Development and evaluation of a fluorophore-fused tool on identification of caspase-2 functions @ Karolinska Institutet 
• Development and validation of novel in vitro models for adverse effects on the human neurovascular unit including compromised barrier properties, and changed cellular transcriptional profiles @ Karolinska Institutet
• Development of a novel 3D hepatic culture system for assessment of hepatotoxicity induced by Gold Nanoparticles @ Trinity College, Dublin, Irland
• Development of a sustainable, cost effective sampling device for air quality monitoring @ Karolinska Institutet
• Development of an air-liquid interface co-culture membrane mimicking alveolar tissue for the testing of nanoparticle toxicity @ Karolinska Institutet
• Developmental toxicity of early-life cadmium exposure: a toxicodynamic – toxicokinetic approach to determine toxic mode of action @ Karolinska Institutet
• Discovery of novel radiosensitisers to treat colorectal cancer @ University of Oxford, UK
• DNA methylation profiles during childhood in relation to prenatal and early-life exposure to noise @ Karolinska Institutet
• Early life arsenic and cadmium exposure and reproductive and growth-related hormones in adolescence @ Karolinska Institutet
• Early-life exposure to cobalt and child development @ Karolinska Institutet
• Effect of selective serotonin reuptake inhibitors on the serotonin system and junctional protein in human placenta @ University of Quebec, Montreal, Canada
• Effects and underlying mechanisms of PFAS and monoalkyl phthalate esters on lipid metabolism in larval zebrafish (Danio rerio) @ Uppsala University
• Effects of deoxynivalenol and zearalenone on oxidative stress in mouse liver and kidney - A potential target for probiotic invention @ University of Hong Kong, China
• Effects of diesel exhaust particle aerosols on human bronchial epithelium 3D models co-cultured with and without macrophages @ Karolinska Institutet
• Effects of EDCs on molecular endpoints in human mesenchymal stem cells @ Uppsala University
• Effects of IL-26 on Human Neutrophils in response to bacterial endotoxin @ Karolinska Institutet
• Effects of phthalate metabolite mixtures on signaling pathways controlling ovarian follicle activation and growth @ Karolinska Institutet
• Electromagnetic radar exposure to neurblastoma and glioma cells in vitro @ Karolinska Institutet
• Electronic cigarette induced pulmonary toxicity and potential protective effects by rosemarinic acid assessed with bronchial and alveolar mucosa models @ Karolinska Institutet
• Elucidating the effects of AMP kinase deficiency in the presence of paraquat-induced toxicity in Drosophila models of Parkinson’s disease @ National University of Singapore
• Endocrine disruptors on the brain: A structured literature review of endocrine disruptors as a risk factor for ADHD @ Karolinska Institutet
• Environmental pollutants in innate immunity @ Karolinska Institutet
• Epigenetic effects of endocrine disrupting chemicals during neuronal differentiation in vitro @ Karolinska Institutet 
• Epigenetic effects of prenatal exposure to lead @ Karolinska Institutet
• Evaluation of human hepatic spheroids as an in vitro model for non-alcoholic steatohepatitis (NASH) @ Karolinska Institutet
• Evaluation of pulmonary toxicity of micro- and nanoplastics using mono- and co-culture models @ Karolinska Institutet
• Evaluation of subtoxic effects of TiO2 nanoparticles in polarised intestinal fish cells(RTgutGC) @ Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
• Evidence-based evaluation of endocrine-disrupting properties, based on EC’s scientific criteria. Silver nanoparticles have the ability to disrupt male testicular steroidogenesis and spermatogenesis @ Karolinska Institutet
• Exploring the role of NRF2 signaling in senescence of primary human fibroblasts @ Stockholm University
• Exposure to environmental phthalates during preschool age and obesity from children to young adulthood @ Karolinska Institutet
• Fluoride in food and drinking water and its association with bone health @ Karolinska Institutet
• Gene expression and DNA methylation analysis in adipose tissue of rodent toxicology models @ Karolinska Institutet
• Genotoxic assessment of oxygenated PAHs @ Karolinska Institutet 
• Gold nanoparticle and macrophage interaction: dissolution and immune-modulation @ Karolinska Institutet
• Health risks of detergents, degreasers and disinfectants available on the Swedish market @ Karolinska Institutet
• Heat shock protein 60 and 90 mediated dendritic cell-T cell interaction in atherosclerosis - Immunomodulatory effect of antibodies against phosphorylcholine @ Karolinska Institutet 
• Human Biomonitoring: Literature review of potential biomarkers for incident (disaster) exposure assessment of hazardous chemicals @ Karolinska Institutet
• Immunogenic effects of lipid peroxidation byproducts in atheroscleortic development and their role in plaque rupture @ Karolinska Institutet
• Immunomodulatory effect of PFOS in intestinal inflammation in genetically-susceptible hosts @ Karolinska Institutet
• Immunomodulatory properties of perfluoroalkyl substances during chemically-induced intestinal inflammation in zebrafish @ Karolinska Institutet
• Implementation of mode of action analysis to study endocrine-mediated effects of phthalates on the male reproductive system @ Charité university, Berlin, Germany
• Inhibiting DNA repair to enhance the activity of anticancer treatments @ The Cancer Research Center of Lyon, France
• In silico based modelling of inhalation toxicokinetics in humans @ Karolinska Institutet
• In vitro toxicity and drug efficacy testing in a 3D tumor spheroid model @ Karolinska Institutet 
• Insufficient ROS production due to Ncf1 mutation promotes pristane-induced lupus in mice @ Karolinska Institutet
• Investigating how overexpression of metallothionein MT1G can sensitize human colorectal cancer cell lines and overcome drug resistance when treated with different doses of Salinomycin @ IMCB, A*STAR, Singapore
• Investigating the activities of microbiota-derived metabolites in inflammatory bowel disease: a zebrafish-based screening analysis @ Karolinska Institutet
• Investigating toxic dose and partitioning of selected cationic surfactants in artificial liposomes and fish gill and liver cells in culture @ University of Utrecht, The Netherlands
• Investigation of potential immunotoxic effects of perfluorinated compounds on innate immunity in humans @Karolinska Institutet
• Investigation of the effects related to long-term polypharmacy exposure in a mouse model of Alzheimer’s disease @ Karolinska Institutet
• Investigation of the effects of polymedication treatment in a mouse model of Alzheimer’s Disease @ Karolinska Institutet
• Investigation of the role of Cajal bodies in DNA repair @ Karolinska Institutet 
• In-vitro and in-vivo investigation of effects of CYP1 inhibitors in AhR signalling pathway @ Karolinska Institutet
• Involvement of PGE2 in cholinergic anti-inflammatory pathway: Potential for treatment of chronic inflammatory diseases @ Karolinska Institutet
• Markers for obesogenic effects of pollutants in developing zebrafish @ Uppsala Universitet, Sweden
• Mechanisms for potentiation of aryl hydrocarbon receptor signaling @ Karolinska Institutet
• Metabolic changes of mature adipocytes exposed to endocrine disrupting chemicals (EDCs) @ Karolinska Institutet
• Metabolic impact of a low-dose mixture of common pollutants in female mice: intestinal outcome of a one-generation study @ Inserm, France
• Metal exposure during pregnancy and telomere length and mtDNA in placenta @ Karolinska Institutet
• Misconceptions of statistical approach towards transformed data: guidelines for toxicologists @ Karolinska Institutet
• Modeling pulmonary microparticle deposition in diseased lungs @ Karolinska Institutet
• Modulation of human steroidogenesis by phthalate mixtures representative of exposure levels in Swedish pregnant women in vitro @ Karolinska Institutet
• Multiplexed and digital protein analysis by next generation sequencing @ Stockholm University, Sweden
• Nano formulations of current therapeutic drug candidates against SARS-Cov-2 for pulmonary delivery: immune modulatory and toxic effects @ Institut de Biologie et Chimie des Protéines, Lyon, France
• Nanoparticle-induced genotoxicity: Primary and inflammatory-driven mechanisms @ Karolinska Institutet
• Novel ex vivo test strategies for testing reproductive toxicity in the female @ Karolinska Institutet
• Nuclear receptors function in the intestinal barrier @ Karolinska Institutet
• Occupational exposure limits for substances classified as reproductive toxicants: Are all workers protected? @ Karolinska Institutet
• Optimization and Pre-validation of the Adipogenesis Assay Using Human Mesenchymal Stem Cells in the Assessment of Metabolism Disrupting Chemicals @ Karolinska Institutet
• Oxidative stress induced pulmonary nanotoxicity in primary bronchial epithelial cells cultured in air-liquid interface @ Karolinska Institutet
• Per- and polyfluoroalkyl substances concentrations in pregnant women and their fetuses explored by maternal-fetal physiologically-based toxicokinetic modelling @ Swedish University of Agricultural Sciences 
• Physiologically based pharmacokinetic modelling of cerium oxide nanoparticle in rats @ Karolinska Institutet
• Population growth dynamics of Pseudomonas aeruginosa and Staphylococcus aureus in the presence and absence of of HQNO and antibiotics within a chemostat @ Karolinska Institutet
• Prediction of in vivo clearance in mice using in silico modelling approaches @ Karolinska Institutet
• Profiling the signaling modalities of anti-diabetic drugs using ebBRET-based biosensors @ Karolinska Institutet
• Prolongation of the proliferative capacity of primary human hepatocytes in vitro @ Karolinska Institutet
• Protective effects of L-serine against the natural BMAA toxin and genetic disposition associated with amyotrophic lateral sclerosis @ University of Bergen, Norway
• Redox-active selenocompound for leukemia treatment: efficacy and toxicity evaluation @ Karolinska Institutet
• Redox homeostasis and inflammatory response against biodiesel and diesel in bronchial epithelial cells and macrophages at air-liquid interface model @ Karolinska Institutet
• Role of mast cell mediators in the early allergic reaction in a novel house dust mite guinea pig model of asthma @ Karolinska Institutet
• Role of the coxsackie- and adenovirus receptor in regulating chemoresistance in breast cancer cells @ Karolinska Institutet
• SciRAPnano: a pragmatic approach for quality evaluation of in vitro toxicity data for risk assessment of nanomaterials @ Karolinska Institutet
• Selective serotonin reuptake inhibitors and autism risk mediated cellular responses during early human neurodevelopment @ Karolinska Institutet
• Serum and urinary hormone disposition in relation to genetic variation of major phase II enzymes and contraceptive use @ Karolinska Institutet
• Skin exposure to endocrine disrupters via consumer products @ Karolinska Institutet
• Strength in complexity: Cytokine and chemokine release screening after exposure to titanium dioxide nanoparticles @ Karolinska Institutet
• Studies of metabolism and toxicity of new psychoactive substances using High-Resolution Mass Spectrometry @ Karolinska Institutet
• Studies of mitochondrial toxicity in small molecule drugs using in silico and in vitro methods @ Karolinska Institutet
• Studies on expression and extracellular export properties for HIV-Peptide epitopes expressed from plasmids and mini-circles @ Karolinska Institutet
• Study on microbial-derived aryl hydrocarbon receptor ligands effects on mouse embryonic neurogenesis @ Nanyang Technological University, Singapore
• Study the effect of Y1830, an herb used in Traditional Chinese Medicine, on estrogen receptor of breast cancer cell lines @ Yale University, USA
• Synergistic cytotoxic effects of MTH1 inhibitor (TH1579) in combination with mitotic inhibitors (vincristine or vinblastine) in prostate cancer cells @ Karolinska Institutet
• The combined effects of PAH mixtures and nutrients on Rhodomonas salina @ Stockholm University
• The effect of macrophage released cytokines on epithelial lung cells after exposure to nickel and nickel oxide nanoparticles @ Karolinska Institutet 
• The effect of phthalates on human ovarian health & function @ Karolinska Institutet
• The genetic landscape of human SLC transporters @ Karolinska Institutet
• The impact of endocrine disrupting chemicals on myocyte differentiation and function @ Karolinska Institutet
• The impact of novel antipsychotic drugs on the prepulse inhibition (PPI) in KMO-knockout mice @ Karolinska Institutet
• ThermoTargetMiner : a thermal proteome solubility/stability database for identification of protein targets and action mechanisms of novel anticancer agents in lung cancer @ Karolinska Institutet
• The role of CYP1/AHR regulation in steroid hormone signaling in ovary @ Karolinska Institutet
• The role of nuclear receptors in modulating PFOS- exacerbated chemically induced intestinal inflammation in zebrafish @ Karolinska Institutet
• Toxicity of copper and silver nanowires in a human in vitro lung model @ Karolinska Institutet
• Toxicokinetic profile of perfluorinated compounds in zebrafish (Danio rerio) embryo @ Karolinska Institutet 
• Unravelling the mechanism of TNF-related apoptosis inducing ligand (TRAIL) sensitization by brefeldin A @ Karolinska Institutet
• Usage of effect-based methods to evaluate the presence of bioactive compounds in food contact materials – focus on paper and cardboard @ Swedish University of Agricultural Sciences 
• Using in-cell western to investigate the DNA damage response to PAHs and PAH mixtures @ Karolinska Institutet
• Using Swedish poisons information centre data to identify chemical accident hazards among children with specific focus on school environment @ Karolinska Institutet
• Utilization of anti-TNF agents in pregnancy and adverse outcomes in pregnant women and their infants - a Swedish population-based cohort @ Karolinska Institutet
• UV-induced oxidative stress effects on the amylin/IAPP hormone @ Stockholm University

Projects performed at authorities or companies

Projects performed outside academia usually also have a supervisor at Karolinska Institutet.

• A health risk assessment of fluoride @ The Swedish Medical Products Agency
• An assessment of the endocrine disruption potential of two commonly used industrial chemicals, a case study @ Perstorp, Sweden
• Assessing the endocrine disruption potential of REACH chemicals: A case study of two plasticizers @ Perstorp, Sweden
• A toxicological cost-benefit analysis of UV-filters in sunscreen products @ Toxintelligence, Sweden
• Benzophenone-3 as a UV-filter: friend or foe? Weight of evidence-based risk assessment of benzophenone-3 as a potential endocrine disruptor according to the European Commission's scientific criteria @ Swedish Medical Products Agency
• Cocktail effects: Influence of selected food additives on the genotoxic potency of acrylamide @ Swedish Food Agency
• Data extraction and Benchmark Dose Modeling of mycotoxin toxicity data in farm animals @ European Food Safety Agency, Italy
• Development of Flow Cytometry-based Assay/s to Monitor Cell Type-Specific Treatment Responses in a Co-culture Model @ AstraZeneca, Sweden
• Evaluation of in silico methods for estimating the outcome of the Local Lymph Node assay @ AstraZeneca, Sweden
• Extended one generation reproductive toxicity study design in REACH - triggers for performance of the F2 generation, the developmental neurotoxicity and developmental immunotoxicity cohorts @ Swedish Chemicals Agency
• High content imaging of drug-induced effects on cell health and morphological features in lung cell lines @ AstraZeneca, Sweden
• Implementation of mode of action analysis to study endocrine-mediated effects of phthalates on the male reproductive system @ Swedish Chemicals Agency
• Implications of the proposed criteria for endocrine disrupting chemicals on the safety assessment of cosmetic products @ Trossa, Sweden
• In silico prediction of nephrotoxicity using synthetic data: A K-NN approach @ RISE, Sweden
• Investigation of mechanisms underpinning Intrahepatic Cholestasis of Pregnancy (ICP) using an AOP approach @ Sahlgrenska hospital, Sweden
• Mitigation of drug-induced pancreatic injury @ AstraZeneca, Sweden
• Multifunctional additives with biocidal function - identification and analysis of regulatory status @ Swedish Chemicals Agency
• Perfluorinated alkyl acids and cholesterol uptake modulation in Caco-2 cells @ Swedish Food Agency
• Preparation of a CLH dossier for the active substance creosote @ Swedish Chemicals Agency
• Proposal of a CLH dossier for copper pyrithione @ Swedish Chemicals Agency
• Qualification of microsampling in the metabolites in safety testing (MIST) analysis @ Admescope Sweden AB
• Raising awareness: Ochratoxin A in blood of Swedish adolescents – possible associations to food intake and toxicokinetic implications on exposure assessment @ Swedish Food Agency
• Setup of an early screening assay for toxicity using high-content imaging of markers for drug-induced oxidative stress in HepG2 cells @ AstraZeneca, Sweden
• Using biomonitoring data for exposure assessments of mycotoxins and associations with background characteristics and diet in Swedish adults @ Swedish Food Agency
• Visualizing drug-induced toxicity in 3D microtissues @ AstraZeneca, Sweden