Master theses at the Toxicology Programme

Projects performed at Swedish or international universities:

Projects at Karolinska Institutet were performed at several different departments. Some of these projects were also included in a publication or report.

• A new in vitro assay to determine the skin sensitizing potency of chemicals with ATX and IL-1b as potential markers @ Karolinska Institutet
• A systematic in vitro lung health risk and toxicity assessment for electronic cigarettes using ALI-3D models @ Karolinska Institutet
• A toxicokinetic model for Zebrafish (Danio rerio) embryo: understanding the influence of exposure systems for different chemicals @ Karolinska Institutet
• All that glitters is not silver – Toxicity of silver nanoparticles in normal human bronchial cells and macrophages @ Karolinska Institutet
• An evaluation of air liquid interface-3D model of human airway mucosa for diacetyl exposure mediated pulmonary toxicity @ Karolinska Institutet
• Analysis of essential and non-essential trace elements in commercial dog foods and canine blood @ Karolinska Institutet
• Assessment of biomass smoke induced pulmonary toxicity and the protective role of magnolol using bronchial and alveolar mucosa models @ Karolinska Institutet
• Assessment of gases and diesel exhaust particles present in air pollution, induced pulmonary toxicity using multi-cellular lung mucosa models @ Karolinska Institutet
• Assessment of pulmonary toxicity following both single and repeated exposure of Diesel Exhaust Particles and gases (NO2 & SO2) using Air-Liquid Interface model @ Karolinska Institutet
• Assessment of short and frequent skin contact with nickel with regards to allergy risk @ Karolinska Institutet Publication►
• Autotaxin as a valuable player for future in vitro testing of skin sensitizers @ Karolinska Institutet
• Benchmark dose analysis for safety assessment in pharmaceutical development @ Karolinska Institutet
• Bioinformatics analysis to reveal effects of cadmium on DNA methylation in the placenta @ Karolinska Institutet
• Biomarkers in head and neck cancer – a wiki to facilitate personalized and predictive medicine @ Karolinska Institutet Publication►
• Can Cadmium exposure lead to the neurodevelopmental outcome of ADHD? @ Karolinska Institutet
• Central dogma of proteomics: application to bacteria treated with antimicrobial agents @ Karolinska Institutet
• Clinical role of antibodies against malondialdehyde (anti-MDA) in Rheumatoid Arthritis and Systemic Lupus Erythematosus @ Karolinska Institutet
• Connecting epigenetic changes induced by the endocrine disruptor bisphenol A with psychiatric disorders @ Karolinska Institutet
• Correlating epigenetic patterns in human samples to exposure and health outcomes @ Karolinska Institutet
• Development and evaluation of a fluorophore-fused tool on identification of caspase-2 functions @ Karolinska Institutet Publication►
• Development of a novel 3D hepatic culture system for assessment of hepatotoxicity induced by Gold Nanoparticles @ Trinity College, Dublin, Irland
• Development of a sustainable, cost effective sampling device for air quality monitoring @ Karolinska Institutet
• Development of an air-liquid interface co-culture membrane mimicking alveolar tissue for the testing of nanoparticle toxicity @ Karolinska Institutet
• Discovery of novel radiosensitisers to treat colorectal cancer @ University of Oxford, UK
• DNA methylation profiles during childhood in relation to prenatal and early-life exposure to noise @ Karolinska Institutet
• Early-life exposure to cobalt and child development @ Karolinska Institutet
• Effect of selective serotonin reuptake inhibitors on the serotonin system and junctional protein in human placenta @ University of Quebec, Montreal, Canada
• Effects of deoxynivalenol and zearalenone on oxidative stress in mouse liver and kidney - A potential target for probiotic invention @ University of Hong Kong, China
• Effects of diesel exhaust particle aerosols on human bronchial epithelium 3D models co-cultured with and without macrophages @ Karolinska Institutet
• Effects of phthalate metabolite mixtures on signaling pathways controlling ovarian follicle activation and growth @ Karolinska Institutet
• Electromagnetic radar exposure to neurblastoma and glioma cells in vitro @ Karolinska Institutet
• Electronic cigarette induced pulmonary toxicity and potential protective effects by rosemarinic acid assessed with bronchial and alveolar mucosa models @ Karolinska Institutet
• Elucidating the effects of AMP kinase deficiency in the presence of paraquat-induced toxicity in Drosophila models of Parkinson’s disease @ National University of Singapore
• Endocrine disruptors on the brain: A structured literature review of endocrine disruptors as a risk factor for ADHD @ Karolinska Institutet
• Environmental pollutants in innate immunity @ Karolinska Institutet
• Epigenetic effects of endocrine disrupting chemicals during neuronal differentiation in vitro @ Karolinska Institutet Publication►
• Epigenetic effects of prenatal exposure to lead @ Karolinska Institutet Publication►
• Evaluation of human hepatic spheroids as an in vitro model for non-alcoholic steatohepatitis (NASH) @Karolinska Institutet
• Evaluation of subtoxic effects of TiO2 nanoparticles in polarised intestinal fish cells(RTgutGC) @ Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
• Evidence-based evaluation of endocrine-disrupting properties, based on EC’s scientific criteria. Silver nanoparticles have the ability to disrupt male testicular steroidogenesis and spermatogenesis @ Karolinska Institutet
• Exposure to environmental phthalates during preschool age and obesity from children to young adulthood @ Karolinska Institutet
• Fluoride in food and drinking water and its association with bone health @ Karolinska Institutet
• Gene expression and DNA methylation analysis in adipose tissue of rodent toxicology models @ Karolinska Institutet
• Genotoxic assessment of oxygenated PAHs @ Karolinska Institutet Publication►
• Gold nanoparticle and macrophage interaction: dissolution and immune-modulation @ Karolinska Institutet
• Heat shock protein 60 and 90 mediated dendritic cell-T cell interaction in atherosclerosis - Immunomodulatory effect of antibodies against phosphorylcholine @ Karolinska Institutet Publication►
• Human Biomonitoring: Literature review of potential biomarkers for incident (disaster) exposure assessment of hazardous chemicals @ Karolinska Institutet
• Immunogenic effects of lipid peroxidation byproducts in atheroscleortic development and their role in plaque rupture @ Karolinska Institutet
• Immunomodulatory properties of perfluoroalkyl substances during chemically-induced intestinal inflammation in zebrafish @ Karolinska Institutet
• Implementation of mode of action analysis to study endocrine-mediated effects of phthalates on the male reproductive system @ Charité university, Berlin, Germany
• In silico based modelling of inhalation toxicokinetics in humans @ Karolinska Institutet
• In vitro toxicity and drug efficacy testing in a 3D tumor spheroid model @ Karolinska Institutet Publication►
• Insufficient ROS production due to Ncf1 mutation promotes pristane-induced lupus in mice @Karolinska Institutet
• Investigating toxic dose and partitioning of selected cationic surfactants in artificial liposomes and fish gill and liver cells in culture @ University of Utrecht, The Netherlands
• Investigation of potential immunotoxic effects of perfluorinated compounds on innate immunity in humans @Karolinska Institutet
• Investigation of the role of Cajal bodies in DNA repair @ Karolinska Institutet Publication►
• In-vitro and in-vivo investigation of effects of CYP1 inhibitors in AhR signalling pathway @ Karolinska Institutet
• Involvement of PGE2 in cholinergic anti-inflammatory pathway: Potential for treatment of chronic inflammatory diseases @ Karolinska Institutet
• Markers for obesogenic effects of pollutants in developing zebrafish @ Uppsala Universitet, Sweden
• Mechanisms for potentiation of aryl hydrocarbon receptor signaling @ Karolinska Institutet
• Metabolic impact of a low-dose mixture of common pollutants in female mice: intestinal outcome of a one-generation study @ Inserm, France
• Misconceptions of statistical approach towards transformed data: guidelines for toxicologists @ Karolinska Institutet
• Modeling pulmonary microparticle deposition in diseased lungs @ Karolinska Institutet
• Modulation of human steroidogenesis by phthalate mixtures representative of exposure levels in Swedish pregnant women in vitro @ Karolinska Institutet
• Multiplexed and digital protein analysis by next generation sequencing @ Stockholm University, Sweden
• Nanoparticle-induced genotoxicity: Primary and inflammatory-driven mechanisms @ Karolinska Institutet
• Novel ex vivo test strategies for testing reproductive toxicity in the female @ Karolinska Institutet
• Nuclear receptors function in the intestinal barrier @ Karolinska Institutet
• Oxidative stress induced pulmonary nanotoxicity in primary bronchial epithelial cells cultured in air-liquid interface @ Karolinska Institutet
• Physiologically based pharmacokinetic modelling of cerium oxide nanoparticle in rats @ Karolinska Institutet
• Population growth dynamics of Pseudomonas aeruginosa and Staphylococcus aureus in the presence and absence of of HQNO and antibiotics within a chemostat @ Karolinska Institutet
• Prediction of in vivo clearance in mice using in silico modelling approaches @ Karolinska Institutet
• Prolongation of the proliferative capacity of primary human hepatocytes in vitro @ Karolinska Institutet
• Role of mast cell mediators in the early allergic reaction in a novel house dust mite guinea pig model of asthma @ Karolinska Institutet
• Role of the coxsackie- and adenovirus receptor in regulating chemoresistance in breast cancer cells @ Karolinska Institutet
• Serum and urinary hormone disposition in relation to genetic variation of major phase II enzymes and contraceptive use @ Karolinska Institutet
• Skin exposure to endocrine disrupters via consumer products @ Karolinska Institutet
• Strength in complexity: Cytokine and chemokine release screening after exposure to titanium dioxide nanoparticles @ Karolinska Institutet
• Studies of metabolism and toxicity of new psychoactive substances using High-Resolution Mass Spectrometry @ Karolinska Institutet
• Studies of mitochondrial toxicity in small molecule drugs using in silico and in vitro methods @ Karolinska Institutet
• Studies on expression and extracellular export properties for HIV-Peptide epitopes expressed from plasmids and mini-circles @ Karolinska Institutet
• Study on microbial-derived aryl hydrocarbon receptor ligands effects on mouse embryonic neurogenesis @ Nanyang Technological University, Singapore
• Study the effect of Y1830, an herb used in Traditional Chinese Medicine, on estrogen receptor of breast cancer cell lines @ Yale University, USA
• Synergistic cytotoxic effects of MTH1 inhibitor (TH1579) in combination with mitotic inhibitors (vincristine or vinblastine) in prostate cancer cells @ Karolinska Institutet
• The effect of macrophage released cytokines on epithelial lung cells after exposure to nickel and nickel oxide nanoparticles @ Karolinska Institutet Publication►
• The effect of phthalates on human ovarian health & function @ Karolinska Institutet
• The genetic landscape of human SLC transporters @ Karolinska Institutet
• The impact of novel antipsychotic drugs on the prepulse inhibition (PPI) in KMO-knockout mice @ Karolinska Institutet
• The role of CYP1/AHR regulation in steroid hormone signaling in ovary @ Karolinska Institutet
• The role of nuclear receptors in modulating PFOS- exacerbated chemically induced intestinal inflammation in zebrafish @ Karolinska Institutet
• Toxicokinetic profile of perfluorinated compounds in zebrafish (Danio rerio) embryo @ Karolinska Institutet Publication►
• Unravelling the mechanism of TNF-related apoptosis inducing ligand (TRAIL) sensitization by brefeldin A @ Karolinska Institutet
• Using Swedish poisons information centre data to identify chemical accident hazards among children with specific focus on school environment @ Karolinska Institutet
• UV-induced oxidative stress effects on the amylin/IAPP hormone @ Stockholm University

Projects performed at authorities or companies

Projects performed outside academia usually also have a supervisor at Karolinska Institutet.

• A health risk assessment of fluoride @ The Swedish Medical Products Agency
• A toxicological cost-benefit analysis of UV-filters in sunscreen products @ Toxintelligence, Sweden
• Cocktail effects: Influence of selected food additives on the genotoxic potency of acrylamide @ Swedish Food Agency
• Data extraction and Benchmark Dose Modeling of mycotoxin toxicity data in farm animals @ European Food Safety Agency, Italy
• Evaluation of in silico methods for estimating the outcome of the Local Lymph Node assay @ AstraZeneca, Sweden
• Extended one generation reproductive toxicity study design in REACH - triggers for performance of the F2 generation, the developmental neurotoxicity and developmental immunotoxicity cohorts @ Swedish Chemicals Agency
• Implementation of mode of action analysis to study endocrine-mediated effects of phthalates on the male reproductive system @ Swedish Chemicals Agency
• Implications of the proposed criteria for endocrine disrupting chemicals on the safety assessment of cosmetic products @ Trossa, Sweden
• Investigation of mechanisms underpinning Intrahepatic Cholestasis of Pregnancy (ICP) using an AOP approach @ Sahlgrenska hospital, Sweden
• Multifunctional additives with biocidal function - identification and analysis of regulatory status @ Swedish Chemicals Agency
• Perfluorinated alkyl acids and cholesterol uptake modulation in Caco-2 cells @ Swedish Food Agency
• Proposal of a CLH dossier for copper pyrithione @ Swedish Chemicals AgencyPreparation of a CLH dossier for the active substance creosote @ Swedish Chemicals Agency
• Raising awareness: Ochratoxin A in blood of Swedish adolescents – possible associations to food intake and toxicokinetic implications on exposure assessment @ Swedish Food Agency
• Setup of an early screening assay for toxicity using high-content imaging of markers for drug-induced oxidative stress in HepG2 cells @ AstraZeneca, Sweden
• Using biomonitoring data for exposure assessments of mycotoxins and associations with background characteristics and diet in Swedish adults @ Swedish Food Agency