Selected publications - Centre for nutrition

Selected publications from Rongrong Fan

Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4.
Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E
Nucleic Acids Res 2023 Feb;51(3):1067-1086

An optimized 4C-seq protocol based on cistrome and epigenome data in the mouse RAW264.7 macrophage cell line.
Huang Z, Wang C, Treuter E, Fan R
STAR Protoc 2022 Jun;3(2):101338

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Huang Z, Liang N, Goñi S, Damdimopoulos A, Wang C, Ballaire R, Jager J, Niskanen H, Han H, Jakobsson T, Bracken AP, Aouadi M, Venteclef N, Kaikkonen MU, Fan R, Treuter E
Mol Cell 2021 Mar;81(5):953-968.e9

PPARα and NCOR/SMRT corepressor network in liver metabolic regulation.
Kang Z, Fan R
FASEB J 2020 Jul;34(7):8796-8809

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R
Nat Commun 2019 Apr;10(1):1684

Selected publications from Andreas Lennartsson

One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies.
Kalushkova A, Nylund P, Párraga AA, Lennartsson A, Jernberg-Wiklund H
Epigenomes 2021 Oct 8;5(4):22

Functional annotation of human long noncoding RNAs via molecular phenotyping.
Ramilowski JA, Yip CW, Agrawal S, Chang JC, Ciani Y, Kulakovskiy IV, et al.
Genome Res 2020 Jul;30(7):1060-1072

AML displays increased CTCF occupancy associated with aberrant gene expression and transcription factor binding.
Mujahed H, Miliara S, Neddermeyer A, Bengtzén S, Nilsson C, Deneberg S, Cordeddu L, Ekwall K, Lennartsson A, Lehmann S
Blood 2020 Jul;136(3):339-352

A regulatory role for CHD2 in myelopoiesis.
Shahin Varnoosfaderani F, Palau A, Dong W, Persson J, Durand-Dubief M, Svensson JP, Lennartsson A
Epigenetics 2020 ;15(6-7):702-714

Selected publications from Marie Löf

Effectiveness of a Smartphone App (MINISTOP 2.0) integrated in primary child health care to promote healthy diet and physical activity behaviors and prevent obesity in preschool-aged children: randomized controlled trial.
Alexandrou C, Henriksson H, Henström M, Henriksson P, Delisle Nyström C, Bendtsen M, Löf M
Int J Behav Nutr Phys Act 2023 Feb;20(1):22

Revisiting the cross-sectional and prospective association of physical activity with body composition and physical fitness in preschoolers: A compositional data approach.
Migueles JH, Delisle Nyström C, Leppänen MH, Henriksson P, Löf M
Pediatr Obes 2022 Feb;():e12909

Effectiveness of a Smartphone App to Promote Healthy Weight Gain, Diet, and Physical Activity During Pregnancy (HealthyMoms): Randomized Controlled Trial.
Sandborg J, Söderström E, Henriksson P, Bendtsen M, Henström M, Leppänen MH, Maddison R, Migueles JH, Blomberg M, Löf M
JMIR Mhealth Uhealth 2021 03;9(3):e26091

Cross-sectional examination of 24-hour movement behaviours among 3- and 4-year-old children in urban and rural settings in low-income, middle-income and high-income countries: the SUNRISE study protocol.
Okely T, Reilly JJ, Tremblay MS, Kariippanon KE, Draper CE, El Hamdouchi A, Florindo AA, Green JP, Guan H, Katzmarzyk PT, Lubree H, Pham BN, Suesse T, Willumsen J, Basheer M, Calleia R, Chong KH, Cross PL, Nacher M, Smeets L, Taylor E, Abdeta C, Aguilar-Farias N, Baig A, Bayasgalan J, Chan CHS, Chathurangana PWP, Chia M, Ghofranipour F, Ha AS, Hossain MS, Janssen X, Jáuregui A, Katewongsa P, Kim DH, Kim TV, Koh D, Kontsevaya A, Leyna GH, Löf M, Munambah N, Mwase-Vuma T, Nusurupia J, Oluwayomi A, Del Pozo-Cruz B, Del Pozo-Cruz J, Roos E, Shirazi A, Singh P, Staiano A, Suherman A, Tanaka C, Tang HK, Teo WP, Tiongco MM, Tladi D, Turab A, Veldman SLC, Webster EK, Wickramasinghe P, Widyastari DA
BMJ Open 2021 10;11(10):e049267

Effectiveness of a 3-Month Mobile Phone-Based Behavior Change Program on Active Transportation and Physical Activity in Adults: Randomized Controlled Trial.
Ek A, Alexandrou C, Söderström E, Bergman P, Delisle Nyström C, Direito A, Eriksson U, Henriksson P, Maddison R, Trolle Lagerros Y, Bendtsen M, Löf M
JMIR Mhealth Uhealth 2020 06;8(6):e18531

Mobile-based intervention intended to stop obesity in preschool-aged children: the MINISTOP randomized controlled trial.
Nyström CD, Sandin S, Henriksson P, Henriksson H, Trolle-Lagerros Y, Larsson C, Maddison R, Ortega FB, Pomeroy J, Ruiz JR, Silfvernagel K, Timpka T, Löf M
Am J Clin Nutr 2017 06;105(6):1327-1335

Selected publications from Federico Pietrocola

Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F
EMBO J 2021 10;40(19):e108863

Chemical activation of SAT1 corrects diet-induced metabolic syndrome.
Castoldi F, Hyvönen MT, Durand S, Aprahamian F, Sauvat A, Malik SA, Baracco EE, Vacchelli E, Opolon P, Signolle N, Lefevre D, Bossut N, Eisenberg T, Dammbrueck C, Pendl T, Kremer M, Lachkar S, Einer C, Michalke B, Zischka H, Madeo F, Keinänen TA, Maiuri MC, Pietrocola F, Kroemer G
Cell Death Differ 2020 10;27(10):2904-2920

Spermidine in health and disease.
Madeo F, Eisenberg T, Pietrocola F, Kroemer G
Science 2018 Jan;359(6374):

Nutrition, inflammation and cancer.
Zitvogel L, Pietrocola F, Kroemer G.
Nat Immunol. 2017 Jul 19;18(8):843-850

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, Chery A, Lachkar S, Sigl V, Bloy N, Buque A, Falzoni S, Ryffel B, Apetoh L, Di Virgilio F, Madeo F, Maiuri MC, Zitvogel L, Levine B, Penninger JM, Kroemer G
Cancer Cell 2016 07;30(1):147-160

Selected publications from Christian Riedel

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.
Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek S
Mol Metab 2021 12;54():101329

DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes.
Sen I, Zhou X, Chernobrovkin A, Puerta-Cavanzo N, Kanno T, Salignon J, Stoehr A, Lin XX, Baskaner B, Brandenburg S, Björkegren C, Zubarev RA, Riedel CG
Nat Commun 2020 01;11(1):138

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.
Lin XX, Sen I, Janssens GE, Zhou X, Fonslow BR, Edgar D, Stroustrup N, Swoboda P, Yates JR, Ruvkun G, Riedel CG
Nat Commun 2018 10;9(1):4400

The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
Heimbucher T, Liu Z, Bossard C, McCloskey R, Carrano AC, Riedel CG, Tanasa B, Klammt C, Fonslow BR, Riera CE, Lillemeier BF, Kemphues K, Yates JR, O'Shea C, Hunter T, Dillin A
Cell Metab 2015 Jul;22(1):151-63

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.
Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G
Nat Cell Biol 2013 May;15(5):491-501

Selected publications from Peter Stenvinkel

Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases.
Stenvinkel P, Painer J, Johnson RJ, Natterson-Horowitz B
J Intern Med 2020 Mar;287(3):238-251

Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage.
Dai L, Schurgers LJ, Shiels PG, Stenvinkel P
Nephrol Dial Transplant 2020 Mar;35(Suppl 2):ii31-ii37

Food as medicine: targeting the uraemic phenotype in chronic kidney disease.
Mafra D, Borges NA, Lindholm B, Shiels PG, Evenepoel P, Stenvinkel P
Nat Rev Nephrol 2021 Mar;17(3):153-171

Manipulating the exposome to enable better ageing.
Shiels PG, Painer J, Natterson-Horowitz B, Johnson RJ, Miranda JJ, Stenvinkel P
Biochem J 2021 Jul;478(14):2889-2898

Fermented food: Should patients with cardiometabolic diseases go back to an early neolithic diet?
Mafra D, Borges NA, Alvarenga L, Ribeiro M, Fonseca L, Leal VO, Shiels PG, Stenvinkel P
Crit Rev Food Sci Nutr 2022 May;():1-24

Selected publications from Eckardt Treuter

Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4.
Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E
Nucleic Acids Res 2023 Jan 5;gkac1230.

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Huang Z, Liang N, Goñi S, Damdimopoulos A, Wang C, Ballaire R, Jager J, Niskanen H, Han H, Jakobsson T, Bracken AP, Aouadi M, Venteclef N, Kaikkonen MU, Fan R, Treuter E
Mol Cell 2021 Mar;81(5):953-968.e9

Loss of G protein pathway suppressor 2 in human adipocytes triggers lipid remodeling by upregulating ATP binding cassette subfamily G member 1.
Barilla S, Liang N, Mileti E, Ballaire R, Lhomme M, Ponnaiah M, Lemoine S, Soprani A, Gautier JF, Amri EZ, Le Goff W, Venteclef N, Treuter E
Mol Metab 2020 Dec;42():101066

G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages.
Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E
FASEB J 2019 Feb;33(2):1631-1643

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.
Fan R, Toubal A, Goñi S, Drareni K, Huang Z, Alzaid F, Ballaire R, Ancel P, Liang N, Damdimopoulos A, Hainault I, Soprani A, Aron-Wisnewsky J, Foufelle F, Lawrence T, Gautier JF, Venteclef N, Treuter E
Nat Med 2016 Jul;22(7):780-91