KI Psychiatric Genomics Institute

Study on mental illness and quality of life before, during and after the covid-19 pandemic, based on a Swedish cohort of 28.000 participants and longitudinal data from questionnaires and national health and population registers. Omtanke2020 is part of the international collaboration COVIDMENT, with an overall cohort of 250.000 participants across six countries (Sweden, Denmark, Estonia, Iceland, Norway, UK).

Using a ‘big data’ approach, we will investigate how and why mental ill-health interacts with cardiovascular disease. Using novel statistical and machine learning approaches, our researchers will identify the genetic, brain and body markers that are common to both conditions.

The Nordic “Tryggve” (it is a pan-Nordic word for “safe” or “secure”) collaboration was initiated in 2017, and brings together leading psychiatric geneticists in Sweden, Denmark, and Norway. The goal of Tryggve is to conduct secure and federated analyses on genomic and register data across Nordic countries.

In collaboration with principal researcher Jens Hjerling-Leffler and his group, we integrate GWAS findings with single-cell transcriptomics data to achieve more comprehensive biological interpretation of the genetic risk loci of complex brain disorders, with a focus on severe psychiatric illness. 

By uniting the global research community, the Psychiatric Genomics Consortium is radically advancing our understanding of the genetics of psychiatric and substance use disorders.  By bringing together genetic data from hundreds of thousands of individuals around the world, the PGC is working to find the genetic variants that change risk of disease. 

Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders.