Xiaoqun Zhang

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

* 2008, Chinese Government Award for Outstanding Self-financed Student
Abroad
* FENS award to young scientists, Barcelona, Spain, 2012.
2003: Medical Degree, China Medical University, Shenyang, China.
2008: Ph.D in Medical Science and in the field of Neuropharmacology,
Karolinska Institutet

Forskningsbeskrivning

The main focus of my research is to study the function of some GPCRs that
are mainly affected in PD and the progressive loss of nigrostriatal
dopaminergic neurons in PD can be influenced by therapeutic approaches that
target those GPCRs. A battery of complementary techniques which include
brain slice electrophysiology and electrochemistry, pharmacology,
biochemistry, histochemistry and behavioral testing in different genetic and
toxic animal models for PD have been used to address all the issues raised
in the projects.

Artiklar

Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2023;34(5):836-846
On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI-MS Imaging
Kaya I; Schembri LS; Nilsson A; Shariatgorji R; Baijnath S; Zhang X; Bezard E; Svenningsson P; Odell LR; Andren PE
Article: NPJ PARKINSON'S DISEASE. 2023;9(1):56
Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice
Skiteva O; Yao N; Mantas I; Zhang X; Perlmann T; Svenningsson P; Chergui K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(22):14290
Impaired Aversive Memory Formation in GPR37L1KO Mice
Veenit V; Zhang X; Paslawski W; Mantas I; Svenningsson P
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2022;72(11):2313-2325
Prosaposin Reduces α-Synuclein in Cells and Saposin C Dislodges it from Glucosylceramide-enriched Lipid Membranes
Kojima R; Zurbruegg M; Li T; Paslawski W; Zhang X; Svenningsson P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(19):12056
Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology
He Y; Zhang X; Flais I; Svenningsson P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;23(1):410
The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
Veenit V; Zhang X; Ambrosini A; Sousa V; Svenningsson P
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(16):8907
Trace Amine-Associated Receptor 1 Contributes to Diverse Functional Actions of O-Phenyl-Iodotyramine in Mice but Not to the Effects of Monoamine-Based Antidepressants
Mantas I; Millan MJ; Di Cara B; Groenink L; Veiga S; Cistarelli L; Brocco M; Bertrand M; Svenningsson P; Zhang X
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2021;60(33):18022-18030
Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology
Kampen S; Duy Vo D; Zhang X; Panel N; Yang Y; Jaiteh M; Matricon P; Svenningsson P; Brea J; Loza MI; Kihlberg J; Carlsson J
Article: BIOLOGICAL PSYCHIATRY. 2021;90(1):16-27
TAAR1-Dependent and-Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition
Mantas I; Vallianatou T; Yang Y; Shariatgorji M; Kalomoiri M; Fridjonsdottir E; Millan MJ; Zhang X; Andren PE; Svenningsson P
Article: NEUROPHARMACOLOGY. 2020;174:108136
NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism
Sitzia G; Mantas I; Zhang X; Svenningsson P; Chergui K
Article: NEUROBIOLOGY OF DISEASE. 2020;137:104738
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy
Hulme H; Fridjonsdottir E; Gunnarsdottir H; Vallianatou T; Zhang X; Wadensten H; Shariatgorji R; Nilsson A; Bezard E; Svenningsson P; Andren PE
Article: NEUROPHARMACOLOGY. 2020;162:107829
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia
Mantas I; Yang Y; Mannoury-la-Cour C; Millan MJ; Zhang X; Svenningsson P
Article: FRONTIERS IN AGING NEUROSCIENCE. 2020;12:84
Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37
Zhang X; Mantas I; Fridjonsdottir E; Andren PE; Chergui K; Svenningsson P
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:304
Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses
Schintu N; Zhang X; Stroth N; Mathe AA; Andren PE; Svenningsson P
Article: NATURE METHODS. 2019;16(10):1021-1028
Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging
Shariatgorji M; Nilsson A; Fridjonsdottir E; Vallianatou T; Kallback P; Katan L; Savmarker J; Mantas I; Zhang X; Bezard E; Svenningsson P; Odell LR; Andren PE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(30):15226-15235
α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients
Paslawski W; Zareba-Paslawska J; Zhang X; Holzl K; Wadensten H; Shariatgorji M; Janelidze S; Hansson O; Forsgren L; Andren PE; Svenningsson P
Article: MOLECULAR PSYCHIATRY. 2018;23(10):2066-2077
Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit
Yao N; Skiteva O; Zhang X; Svenningsson P; Chergui K
Article: CNS NEUROSCIENCE & THERAPEUTICS. 2018;24(2):144-153
CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-D-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease
Nouhi M; Zhang X; Yao N; Chergui K
Article: FRONTIERS IN PHARMACOLOGY. 2018;9:166
Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine
Zhang X; Mantas I; Alvarsson A; Yoshitake T; Shariatgorji M; Pereira M; Nilsson A; Kehr J; Andren PE; Millan MJ; Chergui K; Svenningsson P
Article: EXPERIMENTAL NEUROLOGY. 2017;292:11-20
Asymmetric dopaminergic degeneration and levodopa alter functional corticostriatal connectivity bilaterally in experimental parkinsonism
Monnot C; Zhang X; Nikkhou-Aski S; Damberg P; Svenningsson P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(10):2735-2740
Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease
Green H; Zhang X; Tiklova K; Volakakis N; Brodin L; Berg L; Greengard P; Perlmann T; Svenningsson P
Article: LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.). 2016;23(9):479-485
The GABA_A receptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatum
Zhang X; Yao N; Chergui K
Article: NEUROIMAGE. 2016;136:129-138
Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry
Shariatgorji M; Strittmatter N; Nilsson A; Kallback P; Alvarsson A; Zhang X; Vallianatou T; Svenningsson P; Goodwin RJA; Andren PE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(5):1423-1428
Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice
Marongiu R; Arango-Lievano M; Francardo V; Morgenstern P; Zhang X; Cenci MA; Svenningsson P; Greengard P; Kaplitt MG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(5):1429-1434
p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism
Schintu N; Zhang X; Alvarsson A; Marongiu R; Kaplitt MG; Greengard P; Svenningsson P
Article: NEUROSCIENCE LETTERS. 2016;611:51-58
Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity
Yang J; Hertz E; Zhang X; Leinartaite L; Lundius EG; Li J; Svenningsson P
Article: JOURNAL OF NEUROSCIENCE. 2015;35(41):14057-14069
Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission
Alvarsson A; Zhang X; Stan TL; Schintu N; Kadkhodaei B; Millan MJ; Perlmann T; Svenningsson P
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(10):1714-1722
Lurasidone and fluoxetine reduce novelty-induced hypophagia and NMDA receptor subunit and PSD-95 expression in mouse brain
Stan TL; Sousa VC; Zhang X; Ono M; Svenningsson P
Article: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2015;26(6):934-939
Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines
Shariatgorji M; Nilsson A; Kallback P; Karlsson O; Zhang X; Svenningsson P; Andren PE
Article: NEUROPHARMACOLOGY. 2015;92:108-115
Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B-and GluN2D-containing NMDA receptors
Zhang X; Chergui K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(4):pyu052
Induction of Cannabinoid- and N-Methyl-D-Aspartate Receptor-Mediated Long-Term Depression in the Nucleus Accumbens and Dorsolateral Striatum Is Region and Age Dependent
Zhang X; Feng Z-J; Chergui K
Article: NEURON. 2014;84(4):697-707
Direct Targeted Quantitative Molecular Imaging of Neurotransmitters in Brain Tissue Sections
Shariatgorji M; Nilsson A; Goodwin RJA; Kallback P; Schintu N; Zhang X; Crossman AR; Bezard E; Svenningsson P; Andren PE
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2014;171(16):3938-3945
Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease
Zhang X; Feng Z-J; Chergui K
Article: EXPERIMENTAL NEUROLOGY. 2014;255:154-160
Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease
Feng Z-J; Zhang X; Chergui K
Article: JOURNAL OF NEUROCHEMISTRY. 2014;129(4):581-590
GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease
Zhang X; Feng Z-J; Chergui K
Article: MOLECULAR PSYCHIATRY. 2013;18(10):1096-1105
Bidirectional regulation of emotional memory by 5-HT_1B receptors involves hippocampal p11
Eriksson TM; Alvarsson A; Stan TL; Zhang X; Hascup KN; Hascup ER; Kehr J; Gerhardt GA; Warner-Schmidt J; Arango-Lievano M; Kaplitt MG; Ogren SO; Greengard P; Svenningsson P
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2013;16(4):919-924
Reduced phosphorylation of GluA1 subunits relates to anxiety-like behaviours in mice
Kiselycznyk C; Zhang X; Huganir RL; Holmes A; Svenningsson P
Article: JOURNAL OF NEUROCHEMISTRY. 2012;123(5):811-823
Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice
Egeland M; Zhang X; Millan MJ; Mocaer E; Svenningsson P
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36(12):2117-2125
Ethanol Disrupts the Mechanisms of Induction of Long-Term Potentiation in the Mouse Nucleus Accumbens
Mishra D; Zhang X; Chergui K
Article: NEUROPHARMACOLOGY. 2012;62(1):347-357
Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects
Nilsson A; Stroth N; Zhang X; Qi H; Falth M; Skold K; Hoyer D; Andren PE; Svenningsson P
Article: PSYCHOPHARMACOLOGY. 2011;218(4):621-634
Antidepressant-like properties of sarizotan in experimental Parkinsonism
Zhang X; Egeland M; Svenningsson P
Article: NEUROCHEMISTRY INTERNATIONAL. 2011;59(8):1109-1122
Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways
Szegedi V; Juhasz G; Zhang X; Barkoczi B; Qi H; Madeira A; Kapus G; Svenningsson P; Spedding M; Penke B
Article: NEUROCHEMISTRY INTERNATIONAL. 2011;59(2):280-289
Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression
Madeira A; Yang J; Zhang X; Vikeved E; Nilsson A; Andren PE; Svenningsson P
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2011;519(9):1815-1827
Distribution, Level, Pharmacology, Regulation, and Signaling of 5-HT₆ Receptors in Rats and Marmosets With Special Reference to an Experimental Model of Parkinsonism
Zhang X; Andren PE; Glennon RA; Svenningsson P
Article: BIOLOGICAL PSYCHIATRY. 2010;68(6):528-535
A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor
Warner-Schmidt JL; Chen EY; Zhang X; Marshall JJ; Morozov A; Svenningsson P; Greengard P
Article: MOLECULAR & CELLULAR PROTEOMICS. 2009;8(5):1094-1104
Striatal Alterations of Secretogranin-1, Somatostatin, Prodynorphin, and Cholecystokinin Peptides in an Experimental Mouse Model of Parkinson Disease
Nilsson A; Falth M; Zhang X; Kultima K; Skold K; Svenningsson P; Andren PE
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(2):201-215
S100B overexpressing mutant mice exhibit prolonged behavioural and biochemical responses towards repeated intermittent binge treatments with MDMA
Kindlundh-Hogberg AMS; Zhang X; Svenningsson P
Article: NEUROPHARMACOLOGY. 2009;56(1):37-46
Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation
Qi H; Mailliet F; Spedding M; Rocher C; Zhang X; Delagrange P; McEwen B; Jay TM; Svenningsson P
Article: NEUROPHARMACOLOGY. 2008;54(7):1143-1152
Neurokinin B/NK₃ receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease
Zhang X; Andren PE; Chergui K; Svenningsson P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(6):2163-2168
Evidence for a role of the 5-HT_1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism
Zhang X; Andren PE; Greengard P; Svenningsson P
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(10):3952-3961
Increased striatal mRNA and protein levells of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins
Nilsson A; Skold K; Sjogren B; Svensson M; Piersont J; Zhang X; Caprioli RM; Buijs J; Persson B; Svenningsson P; Andren PE
Article: PHYSIOLOGY AND BEHAVIOR. 2007;92(1-2):29-33
Changes on 5-HT₂ receptor mRNAs in striatum and subthalamic nucleus in Parkinson's disease model
Zhang X; Andren PE; Svenningsson P
Article: BRAIN RESEARCH. 2006;1095(1):207-210
Repeated L-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease
Zhang X; Andren PE; Svenningsson P
Article: JOURNAL OF PROTEOME RESEARCH. 2006;5(2):262-269
Decreased striatal levels of PEP-19 following MPTP lesion in the mouse
Sköld K; Svensson M; Nilsson A; Zhang XQ; Nydahl K; Caprioli RM; Svenningsson P; Andrén PE
Article: SCIENCE. 2006;311(5757):77-80
Alterations in 5-HT_1B receptor function by p11 in depression-like states
Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang XQ; El Yacoubi M; Vaugeois JM; Nomikos GG; Greengard P
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Alla övriga publikationer

Letter: MOVEMENT DISORDERS. 2021;36(5):1278-1280
Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration
Paslawski W; Bergstrom S; Zhang X; Remnestal J; He Y; Boxer A; Manberg A; Nilsson P; Svenningsson P
Published conference paper: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2020;31(12):2553-2557
Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds
Shariatgorji R; Nilsson A; Strittmatter N; Vallianatou T; Zhang X; Svenningsson P; Goodwin RJA; Andren PE
Review: JOURNAL OF PARKINSON’S DISEASE. 2012;2(2):87-106
Studies of Depression-Related States in Animal Models of Parkinsonism
Schintu N; Zhang X; Svenningsson P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S14-S15
GluN2D-containing NMDA receptors in cholinergic interneurons control dopamine release in the mouse striatum
Zhang X; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S181
Sarizotan stimulates cell proliferation in neurogenic regions in experimental Parkinsonism
Egeland M; Zhang X; Svenningsson P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S9-S10
Sarizotan stimulates cell proliferation in neurogenic regions in experimental Parkinsonism
Egeland M; Zhang X; Svenningsson P
Thesis / dissertation: 2008
Neuropharmacological studies of Parkinson's disease with some emphasis on serotonin transmission
Zhang, Xiaoqun

Anställningar

Forskare, Klinisk neurovetenskap, Karolinska Institutet, 2020-

Examina och utbildning

Medicine Doktorsexamen, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2008

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

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