Volker Lauschke
Professor
E-postadress: volker.lauschke@ki.se
Telefon: +46852487711
Mobiltelefon: +46704926778
Besöksadress: Solnavägen 9, Biomedicum, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa Individanpassad medicin och läkemedelsutveckling, 171 77 Stockholm
Artiklar
- Article: ONCOGENE. 2025;:1-11De Mattia E; Park Y; Peruzzi E; Zhou Y; Roncato R; Polesel J; Scarabel L; Schwab M; Guchelaar H-J; Swen JJ; Spina M; Puglisi F; Toffoli G; Lauschke VM; Cecchin E
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2025;:110751Grätz L; Turku A; Kozielewicz P; Bowin C-F; Scharf MM; Voss JH; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Körber M; Lauschke VM; Löber S; Gmeiner P; Schulte G
- Journal article: CELL. 2025;188(19):5429-5431Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandström A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Grätz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T
- Article: CELL. 2025;188(19):5142-5156.e23Motso A; Pelcman B; Kalinovich A; Kahlous NA; Bokhari MH; Dehvari N; Halleskog C; Waara E; de Jong J; Cheesman E; Kallenberg C; Yakala GK; Murad P; Wetterdal E; Andersson P; van Beek S; Sandström A; Alleluia DN; Talamonti E; Youhanna S; Sabatier P; Koenig C; Willems S; Kemas AM; Hutchinson DS; Ham S; Grätz L; Voss J; Marchan-Alvarez JG; Priede M; Jaunsleine K; Spura J; Kovada V; Supe L; Stoddart LA; Holliday ND; Newton PT; Pillon NJ; Schulte G; Summers RJ; Mutule I; Suna E; Olsen JV; Molenaar P; Carlsson J; Lauschke VM; Wright SC; Bengtsson T
- Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025;26(18):8761Moghazy M; Papathanasiou M; Tzoupis H; Papavasileiou KD; Xing C; Lauschke VM; Afantitis A; Melagraki G
- Article: MOLECULAR METABOLISM. 2025;99:102200Smith JAB; Gabriel BM; Brady AJ; Abdelmoez AM; Savikj M; Wright SC; Koutsilieri S; Barres R; Lauschke VM; Krook A; Zierath JR; Pillon NJ
- Article: BIOTECHNOLOGY AND BIOENGINEERING. 2025;122(9):2522-2534Kaellen A; Taebnia N; Widhe M; Lauschke VM; Hedhammar M
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2025;182(14):3353-3370Gasbjerg LS; Rasmussen RS; Dragan A; Lindquist P; Melchiorsen JU; Stepniewski TM; Schiellerup S; Tordrup EK; Gadgaard S; Kizilkaya HS; Willems S; Zhong Y; Wang Y; Wright SC; Lauschke VM; Hartmann B; Holst JJ; Selent J; Rosenkilde MM
- Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 2025;:1-19Codenotti S; Lauschke VM; Casella EV; Andersson DC; Fanzani A; Gastaldello S
- Article: CHEMISTRY-A EUROPEAN JOURNAL. 2025;31(33):e202500382Kehler M; Zhou K; Kemas AM; del Prado A; Hutchinson ES; Nairn EH; Varga M; Plattner Y; Zhong Y; Purewal-Sidhu O; Haslam J; Wiita E; Gildie H; Singerova K; Szaruga Z; Almloef I; Hormann FM; Liu K-C; Wallner O; Ortis F; Homan EJ; Gileadi O; Rudd SG; Stenmark P; de Vega M; Helleday T; D'Arcy-Evans ND; Lauschke VM; Michel M
- Article: CHEMBIOCHEM. 2025;26(11):e202500220Visnes T; Zhou K; Kemas AM; Campopiano D; Lauschke VM; Michel M
- Article: IMETA. 2025;4(3):e70038Pan L; Tang B; Zhang X; Parini P; Tremmel R; Loscalzo J; Lauschke VM; Maron BA; Paci P; Ernberg I; Tan NS; Vegvari A; Liao Z; Rengarajan S; Zubarev R; Fan Y; Zheng X; Jian X; Sheng R; Wang Z; Li X
- Journal article: ENDOCRINE ABSTRACTS. 2025Dekanski A; Li C; Schobloch L; Lindgren E; Wright S; Ferreira D; Lauschke V; Taebnia N; Stener-Victorin E
- Article: JCI INSIGHT. 2025;10(8):e180943Haag M; Winter S; Kemas AM; Tevini J; Feldman A; Eder SK; Felder TK; Datz C; Paulweber B; Liebisch G; Burk O; Lauschke VM; Aigner E; Schwab M
- Journal article: IMETA. 2025;4(3)Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analystPan L; Tang B; Zhang X; Parini P; Tremmel R; Loscalzo J; Lauschke VM; Maron BA; Paci P; Ernberg I; Tan NS; Végvári Á; Liao Z; Rengarajan S; Zubarev R; Fan Y; Zheng X; Jian X; Sheng R; Wang Z; Li X
- Article: DRUG METABOLISM AND DISPOSITION. 2025;53(4):100062Bruecker L; Jacob D; Preiss LC; Zhong Y; Geist F; Hewitt P; Lauschke VM; Petersson C
- Journal article: ENGINEERING. 2025Sheng H; Liang Y; Lauschke VM; Wang Y
- Article: MICROORGANISMS. 2025;13(3):534Ova AO; Joffre E; Shafagh RZ; Assuncao MFG; Sidorov RY; Santos LMA; Lauschke VM; Romling U
- Article: NUCLEIC ACIDS RESEARCH. 2025;53(D1):D1498-D1509Tremmel R; Zhou Y; Camara MD; Laarif S; Eliasson E; Lauschke VM
- Article: METHODS IN MOLECULAR BIOLOGY. 2025;2924:205-215Keulen J; Kemas A; Youhanna S; Shafagh RZ; Lauschke VM
- Article: ADVANCED SCIENCE. 2025;12(3):e2407572Youhanna S; Kemas AM; Wright SC; Zhong Y; Klumpp B; Klein K; Motso A; Michel M; Ziegler N; Shang M; Sabatier P; Kannt A; Sheng H; Oliva-Vilarnau N; Buettner FA; Seashore-Ludlow B; Schreiner J; Windbergs M; Cornillet M; Bjorkstrom NK; Hulsmeier AJ; Hornemann T; Olsen JV; Wang Y; Gramignoli R; Sundstrom M; Lauschke VM
- Article: JOURNAL OF GENETICS AND GENOMICS. 2024;51(11):1228-1236Gonzalez-Padilla D; Camara MD; Lauschke VM; Zhou Y
- Journal article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2024;9(1):269Zhong Y; Lauschke VM
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2024;491:117064He Q; Li M; Ji P; Zheng A; Yao L; Zhu X; Shin J-G; Lauschke VM; Han B; Xiang X
- Article: MOLECULAR THERAPY. 2024;32(9):3012-3024Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Haggblad M; Ilmain J; Wright SC; Murga M; Schlegel J; Jarvius M; Lapins M; Sezgin E; Bhabha G; Lauschke VM; Carreras-Puigvert J; Lafarga M; Klingstrom J; Huhn D; Fernandez-Capetillo O
- Article: CELL DEATH & DISEASE. 2024;15(8):600Guo L; Ma J; Xiao M; Liu J; Hu Z; Xia S; Li N; Yang Y; Gong H; Xi Y; Fu R; Jiang P; Xia C; Lauschke VM; Yan M
- Journal article: NOA. 2024;6(Supplement_1):i37-i38Osman A; Romero AL; Preka E; Pizzirusso G; Arroyo-Garcia LE; Zisiadis GA; Oliva-Vilarnau N; Seitz T; Zhou K; Isla AG; Sun Y; Zhu C; Rodrigues C; Fisahn A; Fragkopoulou A; Lauschke V; Betsholtz C; Blomgren K
- Journal article: NEURO-ONCOLOGY ADVANCES. 2024;6(Suppl 1):i37-i38QSPC-06 TIME-SERIES SINGLE-CELL ANALYSES REVEAL INCESSANT REWIRING OF MICROGLIA AFTER OF CRANIAL IRRADIATION
- Article: NATURE COMPUTATIONAL SCIENCE. 2024;4(8):600-614Yu M; Li W; Yu Y; Zhao Y; Xiao L; Lauschke VM; Cheng Y; Zhang X; Wang Y
- Article: SCIENTIFIC REPORTS. 2024;14(1):17334Mickols E; Meyer A; Handin N; Stuwe M; Eriksson J; Rudfeldt J; Blom K; Fryknas M; Sellin ME; Lauschke VM; Karlgren M; Artursson P
- Article: MOLECULAR METABOLISM. 2024;85:101931Talamonti E; Davegardh J; Kalinovich A; van Beek SMM; Dehvari N; Halleskog C; Bokhari HM; Hutchinson DS; Ham S; Humphrys LJ; Dijon NC; Motso A; Sandstrom A; Zacharewicz E; Mutule I; Suna E; Spura J; Ditrychova K; Stoddart LA; Holliday ND; Wright SC; Lauschke VM; Nielsen S; Scheele C; Cheesman E; Hoeks J; Molenaar P; Summers RJ; Pelcman B; Yakala GK; Bengtsson T
- Article: NATURE METABOLISM. 2024;6(7):1268-1281Kizilkaya HS; Sorensen KV; Madsen JS; Lindquist P; Douros JD; Bork-Jensen J; Berghella A; Gerlach PA; Gasbjerg LS; Mokrosinski J; Mowery SA; Knerr PJ; Finan B; Campbell JE; D'Alessio DA; Perez-Tilve D; Faas F; Mathiasen S; Rungby J; Sorensen HT; Vaag A; Nielsen JS; Holm J-C; Lauenborg J; Damm P; Pedersen O; Linneberg A; Hartmann B; Holst JJ; Hansen T; Wright SC; Lauschke VM; Grarup N; Hauser AS; Rosenkilde MM
- Article: SCIENCE SIGNALING. 2024;17(841):eadi4747Wright SC; Avet C; Gaitonde SA; Muneta-Arrate I; Le Gouill C; Hogue M; Breton B; Koutsilieri S; Alarcia RD; Heroux M; Lauschke VM; Bouvier M
- Article: HEPATOLOGY. 2024;79(6):1337-1351Oliva-Vilarnau N; Beusch CM; Sabatier P; Sakaraki E; Tjaden A; Graetz L; Buettner FA; Dorotea D; Nguyen M; Bergqvist F; Sundstrom Y; Mueller S; Zubarev RA; Schulte G; Tredup C; Gramignoli R; Tietge UJF; Lauschke VM
- Article: NATURE MICROBIOLOGY. 2024;9(5):1499-1512Monteil VM; Wright SC; Dyczynski M; Kellner MJ; Appelberg S; Platzer SW; Ibrahim A; Kwon H; Pittarokoilis I; Mirandola M; Michlits G; Devignot S; Elder E; Abdurahman S; Bereczky S; Bagci B; Youhanna S; Aastrup T; Lauschke VM; Salata C; Elaldi N; Weber F; Monserrat N; Hawman DW; Feldmann H; Horn M; Penninger JM; Mirazimi A
- Article: DRUG METABOLISM AND DISPOSITION. 2024;52(6):539-547Preiss LC; Georgi K; Lauschke VM; Petersson C
- Article: PHARMACOGENOMICS JOURNAL. 2024;24(3):17Zhou Y; Pirmann S; Lauschke VM
- Journal article: DRUG METABOLISM AND DISPOSITION. 2024;52(6):539-547Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.Preiss LC; Georgi K; Lauschke VM; Petersson C
- Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(5):e01390-e01323Camara MD; Zhou Y; Dara A; Tekete MM; de Sousa TN; Sissoko S; Dembele L; Ouologuem N; Togo AH; Alhousseini ML; Fofana B; Sagara I; Djimde AA; Gil PJ; Lauschke VM
- Article: ADVANCED MATERIALS INTERFACES. 2024;11(14)Harris P; Kaveh J; Kemas AM; Mikaelsson H; Fielden M; Lauschke VM; Shafagh RZ
- Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(5):1098-1100Taebnia N; Lauschke VM
- Article: ADVANCED SCIENCE. 2024;11(18):e2307734Buniatian GH; Schwinghammer U; Tremmel R; Cynis H; Weiss TS; Weiskirchen R; Lauschke VM; Youhanna S; Ramos I; Valcarcel M; Seferyan T; Rahfeld J-U; Rieckmann V; Klein K; Buadze M; Weber V; Kolak V; Gebhardt R; Friedman SL; Mueller UC; Schwab M; Danielyan L
- Article: HUMAN GENOMICS. 2024;18(1):40Camara MD; Zhou Y; De Sousa TN; Gil JP; Djimde AA; Lauschke VM
- Article: ISCIENCE. 2024;27(4):109346Di Martino E; Ambikan A; Ramskold D; Umekawa T; Giatrellis S; Vacondio D; Romero AL; Galan MG; Sandberg R; Aden U; Lauschke VM; Neogi U; Blomgren K; Kele J
- Article: GENOME BIOLOGY. 2024;25(1):104Pan L; Parini P; Tremmel R; Loscalzo J; Lauschke V; Maron B; Paci P; Ernberg I; Tan NS; Liao Z; Yin W; Rengarajan S; Li X
- Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Sondergaard JN; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-Andre M; Petersson C; Hagstrom H; Lauschke VM; Archer A; Williams C; Kutter C
- Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(11):2303561Compound Absorption in Polymer Devices Impairs the Translatability of Preclinical Safety AssessmentsKemas AM; Shafagh RZ; Taebnia N; Michel M; Preiss L; Hofmann U; Lauschke VM
- Article: BIOTECHNOLOGY JOURNAL. 2024;19(3):e2300684Koutsilieri S; Mickols E; Vegvari A; Lauschke VM
- Article: BIOTECHNOLOGY JOURNAL. 2024;19(2):e2300587Xing C; Kemas A; Mickols E; Klein K; Artursson P; Lauschke VM
- Article: NATURE COMMUNICATIONS. 2024;15(1):767Lazzeri-Barcelo F; Oliva-Vilarnau N; Baniol M; Leibiger B; Bergmann O; Lauschke VM; Leibiger IB; Moruzzi N; Berggren P-O
- Journal article: OPEN RESEARCH EUROPE. 2024;:194Hakomäki H; Pitkänen S; Levonen A-L; Honkakoski P; Greco D; Saarimäki LA; Viegas S; Godinho C; Fyhrquist N; Wincent E; Lauschke V; Hukkanen J; Hakkola J; Vallier L; Fortino V; Afantitis A; Sawatani T; Guzman T; Cnop M; Nawrot T; Harlid S; Vinnars M-T; Tardon A; Grimalt J; Küblbeck J; Rysä J
- Article: DIABETOLOGIA. 2024;67(1):137-155Ren L; Charbord J; Chu L; Kemas AM; Bertuzzi M; Mi J; Xing C; Lauschke VM; Andersson O
- Article: EMBO JOURNAL. 2023;42(23):e114086Krejcova G; Morgantini C; Zemanova H; Lauschke VM; Kovarova J; Kubasek J; Nedbalova P; Kamps-Hughes N; Moos M; Aouadi M; Dolezal T; Bajgar A
- Journal article: HUMAN GENOMICS. 2023;17(1):105Ingelman-Sundberg M; Nebert DW; Lauschke VM
- Article: ACTA BIOMATERIALIA. 2023;171:336-349Wesseler MF; Taebnia N; Harrison S; Youhanna S; Preiss LC; Kemas AM; Vegvari A; Mokry J; Sullivan GJ; Lauschke VM; Larsen NB
- Journal article: PHARMACOGENOMICS. 2023;24(16):841-844Park Y; Lauschke VM
- Article: NATURE COMMUNICATIONS. 2023;14(1):6785Monteil V; Kwon H; John L; Salata C; Jonsson G; Vorrink SU; Appelberg S; Youhanna S; Dyczynski M; Leopoldi A; Leeb N; Volz J; Hagelkruys A; Kellner MJ; Devignot S; Michlits G; Foong-Sobis M; Weber F; Lauschke VM; Horn M; Feldmann H; Elling U; Penninger JM; Mirazimi A
- Article: NATURE COMMUNICATIONS. 2023;14(1):6243Wright SC; Motso A; Koutsilieri S; Beusch CM; Sabatier P; Berghella A; Blondel-Tepaz E; Mangenot K; Pittarokoilis I; Sismanoglou D-C; Le Gouill C; Olsen JV; Zubarev RA; Lambert NA; Hauser AS; Bouvier M; Lauschke VM
- Journal article: HEPATOBILIARY SURGERY AND NUTRITION. 2023;12(5):78084-78784Lauschke VM
- Article: ACS CHEMICAL BIOLOGY. 2023;18(9):1993-2002Novak M; Vajrychova M; Koutsilieri S; Sismanoglou D-C; Kobrlova T; Prchal L; Svobodova B; Korabecny J; Zarybnicky T; Raisova-Stuchlikova L; Skalova L; Lauschke VM; Kucera R; Soukup O
- Article: NPJ GENOMIC MEDICINE. 2023;8(1):24Tremmel R; Zhou Y; Schwab M; Lauschke VM
- Article: BIOCHEMICAL PHARMACOLOGY. 2023;215:115755Oliva-Vilarnau N; Vorrink SU; Buettner FA; Heinrich T; Sensbach J; Koscielski I; Wienke D; Petersson C; Perrin D; Lauschke VM
- Article: FASEB BIOADVANCES. 2023;5(8):336-353Nilsson G; Mottahedin A; Zelco A; Lauschke VM; Ek CJ; Song J; Ardalan M; Hua S; Zhang X; Mallard C; Hagberg H; Leavenworth JW; Wang X
- Article: NATURE METABOLISM. 2023;5(7):1188-1203Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
- Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s363Lazzeri-Barcelo F; Vilarnau N; Leibiger B; Lauschke V; Leibiger I; Berggren P-O; Moruzzi N
- Article: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2023;80:102057Lauschke VM; Hagberg CE
- Article: PHARMACOGENOMICS JOURNAL. 2023;23(2-3):45-49Skryabin V; Rozochkin I; Zastrozhin M; Lauschke V; Franck J; Bryun E; Sychev D
- Article: STAR PROTOCOLS. 2023;4(2):102260Youhanna S; Bruton J; Jardemark K; Westerblad H; Lauschke VM
- Article: ACS CHEMICAL BIOLOGY. 2023;18(4):822-836Tredup C; Ndreshkjana B; Schneider NS; Tjaden A; Kemas AM; Youhanna S; Lauschke VM; Berger B-T; Kraemer A; Berger LM; Roehm S; Knapp S; Farin HF; Mueller S
- Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 2023;601(8):1317-1318Wright SC; Lauschke VM
- Article: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2023;113(3):712-723Khor CC; Winter S; Sutiman N; Muerdter TE; Chen S; Lim JSL; Li Z; Li J; Sim KS; Ganchev B; Eccles D; Eccles B; Tapper W; Zgheib NKK; Tfayli A; Ng RCH; Yap YS; Lim E; Wong M; Wong NS; Ang PCS; Dent R; Tremmel R; Klein K; Schaeffeler E; Zhou Y; Lauschke VMM; Eichelbaum M; Schwab M; Brauch HBB; Chowbay B; Schroth W
- Article: HUMAN GENOMICS. 2023;17(1):15Zhou Y; Nevosadova L; Eliasson E; Lauschke VMM
- Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2023;224:115154Novak M; Svobodova B; Konecny J; Kuratkova A; Nevosadova L; Prchal L; Korabecny J; Lauschke VM; Soukup O; Kucera R
- Article: LANCET. 2023;401(10374):347-356Swen JJ; van der Wouden CH; Manson LEN; Abdullah-Koolmees H; Blagec K; Blagus T; Boehringer S; Cambon-Thomsen A; Cecchin E; Cheung K-C; Deneer VHM; Dupui M; Ingelman-Sundberg M; Jonsson S; Joefield-Roka C; Just KS; Karlsson MO; Konta L; Koopmann R; Kriek M; Lehr T; Mitropoulou C; Rial-Sebbag E; Rollinson V; Roncato R; Samwald M; Schaeffeler E; Skokou M; Schwab M; Steinberger D; Stingl JC; Tremmel R; Turner RM; van Rhenen MH; Fajardo CLD; Dolzan V; Patrinos GP; Pirmohamed M; Sunder-Plassmann G; Toffoli G; Guchelaar H-J
- Journal article: CURRENT DRUG METABOLISM. 2023;24(2):79Lauschke VM
- Article: NORDIC JOURNAL OF PSYCHIATRY. 2023;77(1):73-76Skryabin VY; Franck J; Lauschke VM; Zastrozhin MS; Shipitsyn VV; Bryun EA; Sychev DA
- Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2023;21:4361-4369Handin N; Yuan D; Olander M; Wegler C; Karlsson C; Jansson-Lofmark R; Hjelmesaeth J; Asberg A; Lauschke VM; Artursson P
- Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2023;280:237-260Zhou Y; Lauschke VM
- Article: ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION. 2023;40(3):519-533Turner J; Pound P; Owen C; Hutchinson I; Hop M; Chau DYS; Silva LVB; Coleman M; Dubourg A; Harries LW; Hutter V; Kenna JG; Lauschke VM; Neuhaus W; Roper C; Watkins PB; Welch J; Alvarez LR; Taylor K
- Article: ISCIENCE. 2022;25(12):105654Gineste C; Youhanna S; Vorrink SU; Henriksson S; Hernandez A; Cheng AJ; Chaillou T; Buttgereit A; Schneidereit D; Friedrich O; Hultenby K; Bruton JD; Ivarsson N; Sandblad L; Lauschke VM; Westerblad H
- Article: ISCIENCE. 2022;25(12):105506Xun D; Chen D; Zhou Y; Lauschke VM; Wang R; Wang Y
- Article: ADVANCED SCIENCE. 2022;9(34):e2203368Shafagh RZ; Youhanna S; Keulen J; Shen JX; Taebnia N; Preiss LC; Klein K; Buettner FA; Bergqvist M; van der Wijngaart W; Lauschke VM
- Article: PHARMACOGENOMICS JOURNAL. 2022;22(5-6):284-293Zhou Y; Lauschke VM
- Article: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2022;148(12):3293-3302Xiao Q; Koutsilieri S; Sismanoglou D-C; Lauschke VM
- Journal article: ANNALS OF TRANSLATIONAL MEDICINE. 2022;10(23):1293-0Zhou Y; Lauschke VM
- Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;154:113644De Mattia E; Silvestri M; Polesel J; Ecca F; Mezzalira S; Scarabel L; Zhou Y; Roncato R; Lauschke VM; Calza S; Spina M; Puglisi F; Toffoli G; Cecchin E
- Article: JOURNAL OF PERSONALIZED MEDICINE. 2022;12(7):1187Ivanov HY; Grigorova D; Lauschke VM; Velinov B; Stoychev K; Kyosovska G; Shopov P
- Journal article: JOURNAL OF HEPATOLOGY. 2022;77:S665-S666Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke V; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; v.B. Hjelmborg J; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kahler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Makitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Ramo J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
- Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(5):973Wyckelsma VL; Venckunas T; Houweling PJ; Schlittler M; Lauschke VM; Tiong CF; Wood HD; Paulauskas H; Eimantas N; Andersson DC; North KN; Brazaitis M; Westerblad H
- Article: PHARMACEUTICS. 2022;14(5):944Dagli-Hernandez C; Borges JB; Rodrigues Marcal EDS; Costa de Freitas RC; Mori AA; Goncalves RM; Faludi AA; de Oliveira VF; Ferreira GM; Bastos GM; Zhou Y; Lauschke VM; Cerda A; Hirata MH; Crespo Hirata RD
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- Preprint: BIORXIV. 2023Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Häggblad M; Ilmain J; Wright S; Murga M; Shlegel J; Sezgin E; Bhabha G; Lauschke V; Lafarga M; Klingström J; Huhn D; Fernandez-Capetillo O
- Preprint: BIORXIV. 2023Sommerauer C; Gallardo-Dodd C; Savva C; Hases L; Birgersson M; Indukuri R; Shen J; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke V; Archer A; Williams C; Kutter C
- Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S355Yakala GK; Talamonti E; Kalinovich A; van Beek SMM; Holliday ND; Suna E; Mutule I; Wright SC; Lauschke VM; Nielsen S; Scheele C; Summers RJ; Hoeks J; Pelcman B; Bengtsson T
- Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S503Moruzzi N; Lazzeri-Barcelo F; Oliva-Vilarnau N; Baniol M; Leibiger B; Bergmann O; Lauschke VM; Leibiger IB; Berggren P-O
- Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S363Lazzeri-Barcelo F; Vilarnau N; Leibiger B; Lauschke V; Leibiger I; Berggren P-O; Moruzzi N
- Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2023;396:S52Tremmel R; Zhou Y; Nevosadova L; Laarif S; Eliasson E; Lauschke VM
- Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2023;396:S52Haag M; Winter S; Kemas AM; Tevini J; Feldman A; Eder S; Felder TK; Datz C; Liebisch G; Burk O; Paulweber B; Lauschke VM; Schwab M; Aigner E
- Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2023;396:S52Klein K; Nies AT; Haag M; Hofmann U; Artursson P; Handin N; Burk O; Tremmel R; Winter S; Zhou Y; Schaeffeler E; Zanger UM; Lauschke VM; Schwab M
- Conference publication: 2023Lauschke VM
- Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2022;131(6):452-464Zhou Y; Koutsilieri S; Eliasson E; Lauschke VM
- Review: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2022;112(6):1159-1171Rodriguez-Antona C; Savieo JL; Lauschke VM; Sangkuhl K; Drogemoller BI; Wang D; Schaik RNH; Gilep AA; Peter AP; Boone EC; Ramey BE; Klein TE; Whirl-Carrillo M; Pratt VM; Gaedigk A
- Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2022;43(10):852-865Zhou Y; Tremmel R; Schaeffeler E; Schwab M; Lauschke VM
- Conference publication: JOURNAL OF HEPATOLOGY. 2022;77:S756-S757Barreby E; Strunz B; Azzimato V; Shen JX; Naudet L; Sonnerborg I; Sulen A; Nock S; Levi L; Morgantini C; Fardellas A; Johansson H; Nowak G; Stal P; Ellis E; Naslund E; Lauschke V; Bjorkstrom N; Chen P; Aouadi M
- Review: HUMAN GENETICS. 2022;141(6):1113-1136Zhou Y; Lauschke VM
- Review: PHARMACOLOGICAL REPORTS. 2022;74(1):47-66Dagli-Hernandez C; Zhou Y; Lauschke VM; Genvigir FDV; Hirata TDC; Hirata MH; Hirata RDC
- Book chapter: COMPREHENSIVE PHARMACOLOGY. 2022;p. 53-83Zhou Y; Lauschke VM
- Review: PHARMACOLOGICAL REVIEWS. 2022;74(1):141-206Youhanna S; Kemas AM; Preiss L; Zhou Y; Shen JX; Cakal SD; Paqualini FS; Goparaju SK; Shafagh RZ; Lind JU; Sellgren CM; Lauschke VM
- Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2022;130:5-15Ingelman-Sundberg M; Lauschke VM
- Review: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS. 2022;22(13):1263-1275Genvigir FDV; Dagli-Hernandez C; Hirata TDC; Zhou Y; Lauschke VM; Hirata MH; Hirata RDC
- Preprint: BIORXIV. 2021Xun D; Chen D; Zhou Y; Lauschke V; Wang R; Wang Y
- Review: MOLECULAR DIAGNOSIS & THERAPY. 2021;25(6):735-755Crespo Hirata TD; Dagli-Hernandez C; Dalla Vecchia Genvigir F; Lauschke VM; Zhou Y; Hirata MH; Crespo Hirata RD
- Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):8Hellstrom W; Ekstrom C; Bruschettini M; Carey G; Barton N; Lauschke VM; Vallius-Kvist S; Wang X; Ley D
- Review: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2021;110(3):626-636Zhou Y; Lauschke VM
- Review: CLINICAL PHARMACOLOGY & THERAPEUTICS. 2021;110(1):82-97Desta Z; El-Boraie A; Gong L; Somogyi AA; Lauschke VM; Dandara C; Klein K; Miller NA; Klein TE; Tyndale RF; Whirl-Carrillo M; Gaedigk A
- Review: DRUG METABOLISM REVIEWS. 2021;53(2):207-233Yadav J; El Hassani M; Sodhi J; Lauschke VM; Hartman JH; Russell LE
- Review: DRUG METABOLISM REVIEWS. 2021;53(2):253-278Russell LE; Zhou Y; Almousa AA; Sodhi JK; Nwabufo CK; Lauschke VM
- Review: DRUG METABOLISM REVIEWS. 2021;53(2):245-252Lauschke VM
- Preprint: BIORXIV. 2021Gineste C; Youhanna S; Vorrink S; Henriksson S; Hernández A; Cheng A; Chaillou T; Buttgereit A; Schneidereit D; Friedrich O; Hultenby K; Bruton J; Ivarsson N; Sandblad L; Lauschke V; Westerblad H
- Review: JOURNAL OF PHARMACEUTICAL SCIENCES. 2021;110(1):50-65Youhanna S; Lauschke VM
- Review: PHARMACOGENOMICS. 2020;21(18):1299-1310Xiao Q; Zhou Y; Lauschke VM
- Preprint: BIORXIV. 2020Wyckelsma VL; Venckunas T; Houweling PJ; Schlittler M; Lauschke VM; Tiong CF; Wood H; Ivarsson N; Paulauskas H; Eimantas N; Andersson DC; North KN; Brazaitis M; Westerblad H
- Review: DRUG METABOLISM REVIEWS. 2020;52(3):395-407Russell LE; Schleiff MA; Gonzalez E; Bart AG; Broccatelli F; Hartman JH; Humphreys WG; Lauschke VM; Martin I; Nwabufo C; Prasad B; Scott EE; Segall M; Takahashi R; Taub ME; Sodhi JK
- Preprint: RESEARCH SQUARE. 2020Stebbing J; Krishnan V; de Bono S; Ottaviani S; Casalini G; Richardson P; Monteil V; Lauschke V; Mirazimi A; Terres JR; Nickoloff B; Higgs R; Rocha G; Byers N; Schlichting D; Cardoso A; Corbellino M
- Review: NPJ GENOMIC MEDICINE. 2020;5(1):9Lauschke VM; Ingelman-Sundberg M
- Review: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(1):38-60Shen JX; Youhanna S; Shafagh RZ; Kele J; Lauschke VM
- Review: JOURNAL OF CLINICAL MEDICINE. 2020;9(1):E286-286Xiao Q; Nobre A; Pineiro P; Berciano-Guerrero M-A; Alba E; Cobo M; Lauschke VM; Barragan I
- Review: FRONTIERS IN PHARMACOLOGY. 2019;10:1093Zhou Y; Shen JX; Lauschke VM
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:545-546Santos M; Niemi M; Hiratsuka M; Kumondai M; Ingelman-Sundberg M; Lauschke VM; Rodriguez-Antona C
- Review: BIOTECHNOLOGY JOURNAL. 2019;14(7):e1800347Lauschke VM; Shafagh RZ; Hendriks DFG; Ingelman-Sundberg M
- Review: PHARMACOLOGY & THERAPEUTICS. 2019;197:122-152Lauschke VM; Zhou Y; Ingelman-Sundberg M
- Review: FRONTIERS IN PHARMACOLOGY. 2018;9:1437Zhou Y; Fujikura K; Mkrtchian S; Lauschke VM
- Conference publication: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2018;123:89Santos M; Niemi M; Hiratsuka M; Kumondai M; Ingelman-Sundberg M; Lauschke VM; Rodriguez-Antona C
- Preprint: BIORXIV. 2018Reisberg S; Krebs K; Kals M; Mägi R; Metsalu K; Lauschke V; Vilo J; Milani L
- Review: FRONTIERS IN MEDICINE. 2018;5:192Oliva-Vilarnau N; Hankeova S; Vorrink SU; Mkrtchian S; Andersson ER; Lauschke VM
- Conference publication: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2018;123:5Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke V
- Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2018;58:65-82Ewart L; Dehne E-M; Fabre K; Gibbs S; Hickman J; Hornberg E; Ingelman-Sundberg M; Jang K-J; Jones DR; Lauschke VM; Marx U; Mettetal JT; Pointon A; Williams D; Zimmermann W-H; Newham P
- Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2018;58:161-185Lauschke VM; Barragan I; Ingelman-Sundberg M
- Review: AAPS JOURNAL. 2017;20(1):4Lauschke VM; Milani L; Ingelman-Sundberg M
- Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2017;38(9):765-770Lauschke VM; Ivanov M; Ingelman-Sundberg M
- Review: CHEMICAL RESEARCH IN TOXICOLOGY. 2016;29(12):1936-1955Lauschke VM; Hendriks DFG; Bell CC; Andersson TB; Ingelman-Sundberg M
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(10):E1714-1714Lauschke VM; Ingelman-Sundberg M
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Forskningsbidrag
- Swedish Research Council1 December 2024 - 30 November 2027Primary human hepatocytes rapidly lose their functionality in conventional 2D cultures, which significantly limits their usefulness as an in vitro model to study hepatotoxicity, particularly of biological and nanoparticle therapeutics, which commonly accumulate and exert their effects over prolonged periods of time. Thus, in the absence of relevant in vitro systems, animal models constitute a cornerstone to predict the toxicity of newly developed biologics. The liver is however an organ with pronounced species differences with regards to expression and catalytic activities of factors involved in drug absorption, distribution, metabolism and excretion. This is further amplified for nucleotide- and antibody-based therapeutics where sequence and epitope differences between species are common problems during preclinical development.We have previously developed a 3D human liver model that accurately predicts the hepatotoxicity of small molecules, which is by now widely used in industry. Here, we aim to extend this work and develop and benchmark a platform that can predict hepatotoxicity and liver biodistribution of biologics (antisense oligonucleotides, siRNAs, therapeutic antibodies) and different nanoparticles (lipid-based, polymeric and inorganic). This system aspires to improve the predictability and translatability of findings as well as to mitigate the need for animal models, thus reducing the number of animals needed in pre-clinical discovery and development.
- Swedish Research Council1 January 2024 - 31 December 2028Non-alcoholic steatohepatitis (NASH) is a prevalent liver disease that affects up to 2-6% of the general population and 15-40% of obese persons. NASH is characterized by steatosis, chronic inflammation and hepatocyte injury and is prone to progress into liver cirrhosis and liver cancer. However, despite tremendous efforts, there are currently no approved treatments for NASH. NASH is closely linked to obesity, sarcopenia, dyslipidemia and insulin resistance and it has become clear that multiple extrahepatic tissues, including pancreas, skeletal muscle and adipose tissue produce signals that orchestrate hepatic metabolism, inflammation and fibrosis. However, the underlying mechanisms in humans remain poorly understood.Here, we will integrate patient-derived ex vivo tissue models of liver, pancreas, skeletal muscle and fat to comprehensively map human metabolic crosstalk. By analyzing the secretome from healthy and diseased individuals, we will identify novel endocrine signals that contribute to NASH etiology and progression. Moreover, we will use the established platform to screen chemogenomic libraries to identify compounds that activate “healthy” signals or inhibit “disease” cues. This project thus provides a conceptually novel perspective that considers NASH as a complex pathology caused by dysregulated tissue interactions and targets these disease mechanisms, which are neglected by current drug development programs, to finally develop effective treatments.
- Chemogenomic profiling of nuclear hormone receptors as targets for NASHNovo Nordisk Foundation1 November 2023 - 31 October 2025Non-alcoholic steatohepatitis (NASH) is a very common liver disease that affects around 1/3 of all obese persons worldwide. NASH is caused by buildup of fat in the liver, which results in inflammation and liver damage. Despite its prevalence, there are currently no approved treatments for NASH._x000D_ In this project we aim to facilitate the development of novel drugs against NASH by targeting a protein family called nuclear receptors (NRs). Specifically, we will culture liver cells isolated from NASH patients as 3D liver microtissues and treat those micro-livers with hundreds of different substances that specifically target NRs. This approach will allow us to directly identify which substances reduce fat buildup, inflammation or liver injury. Such “hit molecules” will then be validated in animal models of NASH and provide good candidates to finally develop effective treatments for this prevalent disease._x000D_
- Swedish Research Council1 January 2023 - 31 December 2026The availability of relevant in vitro models of tissue units would be highly valuable for our struggles to understand human biology and physiology to obtain better health solutions. In the native tissue, cells are organized by a supporting extracellular matrix (ECM) in various types of microenvironments. ECM proteins build up the frameworks of these different environments, e.g. interstitial fiber networks in connective tissue and basement membranes in biological barriers. It has lately become clear that cells in culture are largely affected by their microenvironment, and especially mechanotransduction and the availability of cell-cell and cell-matrix connections. We will herein use a functionalised recombinant spider silk protein to construct relevant ECM-mimics, both networks for parenchymal and support cells in tissue compartments, and membranes for their biological barriers. These we will use to survey the effect of different parameters of the environment for cells in culture. For investigations of biological processes, it is essential to include a combination of cellular compartments and biological barriers. We will use our obtained knowledge to construct physiologically relevant tissue units of 1) tumours in stroma with blood vessels, for investigations of the interplay between cancer cells and vasculature, as well as 2) tumours behind blood brain barrier (BBB), for investigation of treatment strategies of brain tumours.
- Deutsche Forschungsgemeinschaft1 January 2023Non-alcoholic steatohepatitis (NASH) is a serious liver disease characterized by fat accumulation, inflammation, and fibrosis. It affects ~6% of the global population but lacks effective treatment options and is thus a severe medical and healthcare challenge. Pharmacological treatment options are urgently needed to address this unmet medical need. Therapeutic modulation of nuclear receptors (NRs), many of which crucially regulate hepatic metabolism and inflammation, is increasingly recognized as potential avenue to hepatoprotective NASH treatment. However, only a minor fraction of the 48 human NRs has been evaluated in this context and comprehensive understanding of the entire NR family’s involvement in NASH pathology is lacking. Growing evidence supports remarkable potential of many (orphan) NRs to mediate beneficial therapeutic effects in NASH. For example, relevant sex-specific differences in NASH incidence point to an involvement of steroid hormones which act via NR activation. The role of hormone sensing and other NRs in the disease complex urgently requires systematic and comprehensive evaluation for therapeutic potential. This project aims to close this gap by systematically probing NR modulation for therapeutic effects in a primary patient-derived tissue model following a chemogenomics (CG) strategy. To meet its main objective of achieving comprehensive understanding of the pharmacological role of NRs in NASH, the project will assemble a custom CG compound set to cover ≥40 of the 48 human NRs and systematically assess the phenotypic outcomes of NR modulation in liver spheroids generated from primary human hepatocytes and non-parenchymal liver cells. Using such sophisticated in vitro model to mimic relevant disease characteristics aims to overcome incomplete translation from rodent model to patient in NASH and to capture individual and sex-specific differences. Primary evaluation will focus on anti-steatotic, anti-inflammatory, anti-fibrotic, and anti-oxidative effects in a global, sex-specific, and genotype-dependent manner. Subsequently, beneficial effects resulting from NR modulation will be orthogonally validated and analyzed in-depth for sex- and patient-specific roles, dependence on metabolic parameters, potential synergies of dual modulation, and signaling networks. This unprecedented systematic and comprehensive approach to explore NRs as therapeutic targets for NASH treatment will reveal uncharted potential of this protein family and address an urgent unmet medical need. Additionally, new insights into the roles of steroid hormones as well as sex- and patient-specific differences in NASH will offer significant biological advance and may suggest personalized treatment strategies.
- Swedish Research Council1 January 2022 - 31 December 2025Non-alcoholic steatohepatitis (NASH) is a prevalent liver disease that affects up to 2-6% of the general population and 15-40% of obese persons. NASH is characterized by steatosis, chronic inflammation and hepatocyte injury and is prone to progress into liver cirrhosis and liver cancer. However, despite tremendous efforts, there are currently no approved treatments for NASH. NASH is closely linked to obesity, dyslipidemia and insulin resistance and it has become clear that that the adipose tissue produces many signals that control hepatic metabolism, inflammation and fibrosis. However, the underlying mechanisms in humans are poorly understood.Here, we will integrate patient-derived ex vivo tissue models of liver and fat to comprehensively map human fat-liver metabolic crosstalk. By analyzing the secretome of adipose tissue from lean insulin-sensitive and obese insulin-resistant individuals, we will identify novel endocrine signals of human fat that promote or prevent NASH. Moreover, we will use the established platform to screen libraries of lead-like molecules to identify compounds that activate “healthy” signals or inhibit “disease” cues. This project thus provides a conceptually novel perspective that considers NASH as a complex pathology caused by dysregulated tissue interactions and targets these disease mechanisms, which are neglected by current drug development programs, to finally develop effective treatments.
- Swedish Research Council1 December 2019 - 31 December 2022
- Swedish Research Council1 January 2017 - 31 December 2020
- Swedish Research Council1 January 2017 - 31 December 2019
- Swedish Research Council1 January 2016 - 31 December 2016
Anställningar
- Professor, Fysiologi och farmakologi, Karolinska Institutet, 2023-
Examina och utbildning
- Docent, Farmakologi, Karolinska Institutet, 2018