Volker Lauschke

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: ADVANCED SCIENCE. 2024;:e2407572
Chemogenomic Screening in a Patient-Derived 3D Fatty Liver Disease Model Reveals the CHRM1-TRPM8 Axis as a Novel Module for Targeted Intervention
Youhanna S; Kemas AM; Wright SC; Zhong Y; Klumpp B; Klein K; Motso A; Michel M; Ziegler N; Shang M; Sabatier P; Kannt A; Sheng H; Oliva-Vilarnau N; Buettner FA; Seashore-Ludlow B; Schreiner J; Windbergs M; Cornillet M; Bjorkstrom NK; Hulsmeier AJ; Hornemann T; Olsen JV; Wang Y; Gramignoli R; Sundstrom M; Lauschke VM
Article: NUCLEIC ACIDS RESEARCH (NAR). 2024;:gkae1016
PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes
Tremmel R; Zhou Y; Camara MD; Laarif S; Eliasson E; Lauschke VM
Article: JOURNAL OF GENETICS AND GENOMICS. 2024;51(11):1228-1236
Population-scale variability of the human UDP-glycosyltransferase gene family
Gonzalez-Padilla D; Camara MD; Lauschke VM; Zhou Y
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2024;491:117064
Comparison of drug-induced liver injury risk between propylthiouracil and methimazole: A quantitative systems toxicology approach
He Q; Li M; Ji P; Zheng A; Yao L; Zhu X; Shin J-G; Lauschke VM; Han B; Xiang X
Journal article: OPEN RESEARCH EUROPE. 2024;4:194
Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
Hakomäki H; Pitkänen S; Levonen A-L; Honkakoski P; Greco D; Saarimäki LA; Viegas S; Godinho C; Fyhrquist N; Wincent E; Lauschke VM; Hukkanen J; Hakkola J; Vallier L; Fortino V; Afantitis A; Sawatani T; Guzman TJ; Cnop M; Nawrot T; Harlid S; Vinnars M-T; Tardon A; Grimalt JO; Küblbeck J; Rysä J
Article: MOLECULAR THERAPY. 2024;32(9):3012-3024
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Haggblad M; Ilmain J; Wright SC; Murga M; Schlegel J; Jarvius M; Lapins M; Sezgin E; Bhabha G; Lauschke VM; Carreras-Puigvert J; Lafarga M; Klingstrom J; Huhn D; Fernandez-Capetillo O
Article: CELL DEATH AND DISEASE. 2024;15(8):600
The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis
Guo L; Ma J; Xiao M; Liu J; Hu Z; Xia S; Li N; Yang Y; Gong H; Xi Y; Fu R; Jiang P; Xia C; Lauschke VM; Yan M
Journal article: NOA. 2024;6(Supplement_1):i37-i38
QSPC-06 TIME-SERIES SINGLE-CELL ANALYSES REVEAL INCESSANT REWIRING OF MICROGLIA AFTER OF CRANIAL IRRADIATION
Osman A; Romero AL; Preka E; Pizzirusso G; Arroyo-Garcia LE; Zisiadis GA; Oliva-Vilarnau N; Seitz T; Zhou K; Isla AG; Sun Y; Zhu C; Rodrigues C; Fisahn A; Fragkopoulou A; Lauschke V; Betsholtz C; Blomgren K
Article: NATURE COMPUTATIONAL SCIENCE. 2024;4(8):600-614
Deep learning large-scale drug discovery and repurposing
Yu M; Li W; Yu Y; Zhao Y; Xiao L; Lauschke VM; Cheng Y; Zhang X; Wang Y
Article: SCIENTIFIC REPORTS. 2024;14(1):17334
OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
Mickols E; Meyer A; Handin N; Stuwe M; Eriksson J; Rudfeldt J; Blom K; Fryknas M; Sellin ME; Lauschke VM; Karlgren M; Artursson P
Article: NATURE METABOLISM. 2024;6(7):1268-1281
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
Kizilkaya HS; Sorensen KV; Madsen JS; Lindquist P; Douros JD; Bork-Jensen J; Berghella A; Gerlach PA; Gasbjerg LS; Mokrosinski J; Mowery SA; Knerr PJ; Finan B; Campbell JE; D'Alessio DA; Perez-Tilve D; Faas F; Mathiasen S; Rungby J; Sorensen HT; Vaag A; Nielsen JS; Holm J-C; Lauenborg J; Damm P; Pedersen O; Linneberg A; Hartmann B; Holst JJ; Hansen T; Wright SC; Lauschke VM; Grarup N; Hauser AS; Rosenkilde MM
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2024
Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge
Gasbjerg LS; Rasmussen RS; Dragan A; Lindquist P; Melchiorsen JU; Stepniewski TM; Schiellerup S; Tordrup EK; Gadgaard S; Kizilkaya HS; Willems S; Zhong Y; Wang Y; Wright SC; Lauschke VM; Hartmann B; Holst JJ; Selent J; Rosenkilde MM
Article: MOLECULAR METABOLISM. 2024;85:101931
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis
Talamonti E; Davegardh J; Kalinovich A; van Beek SMM; Dehvari N; Halleskog C; Bokhari HM; Hutchinson DS; Ham S; Humphrys LJ; Dijon NC; Motso A; Sandstrom A; Zacharewicz E; Mutule I; Suna E; Spura J; Ditrychova K; Stoddart LA; Holliday ND; Wright SC; Lauschke VM; Nielsen S; Scheele C; Cheesman E; Hoeks J; Molenaar P; Summers RJ; Pelcman B; Yakala GK; Bengtsson T
Article: SCIENCE SIGNALING. 2024;17(841):eadi4747
Conformation- and activation-based BRET sensors differentially report on GPCR-G protein coupling
Wright SC; Avet C; Gaitonde SA; Muneta-Arrate I; Le Gouill C; Hogue M; Breton B; Koutsilieri S; Alarcia RD; Heroux M; Lauschke VM; Bouvier M
Article: NATURE MICROBIOLOGY. 2024;9(5):1499-1512
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Monteil VM; Wright SC; Dyczynski M; Kellner MJ; Appelberg S; Platzer SW; Ibrahim A; Kwon H; Pittarokoilis I; Mirandola M; Michlits G; Devignot S; Elder E; Abdurahman S; Bereczky S; Bagci B; Youhanna S; Aastrup T; Lauschke VM; Salata C; Elaldi N; Weber F; Monserrat N; Hawman DW; Feldmann H; Horn M; Penninger JM; Mirazimi A
Article: DRUG METABOLISM AND DISPOSITION. 2024;52(6):539-547
Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds
Preiss LC; Georgi K; Lauschke VM; Petersson C
Article: HEPATOLOGY. 2024;79(6):1337-1351
Wnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes
Oliva-Vilarnau N; Beusch CM; Sabatier P; Sakaraki E; Tjaden A; Graetz L; Buettner FA; Dorotea D; Nguyen M; Bergqvist F; Sundstrom Y; Mueller S; Zubarev RA; Schulte G; Tredup C; Gramignoli R; Tietge UJF; Lauschke VM
Article: PHARMACOGENOMICS JOURNAL. 2024;24(3):17
APF2: an improved ensemble method for pharmacogenomic variant effect prediction
Zhou Y; Pirmann S; Lauschke VM
Journal article: DRUG METABOLISM AND DISPOSITION. 2024;52(6):539-547
Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds.
Preiss LC; Georgi K; Lauschke VM; Petersson C
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2024;68(5):e01390-e01323
Population-specific variations in KCNH2 predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Camara MD; Zhou Y; Dara A; Tekete MM; de Sousa TN; Sissoko S; Dembele L; Ouologuem N; Togo AH; Alhousseini ML; Fofana B; Sagara I; Djimde AA; Gil PJ; Lauschke VM
Article: ADVANCED MATERIALS INTERFACES. 2024;11(14)
Robust and Seamless Integration of Thiol-Ene-Epoxy Thermosets with Thermoplastics and Glass as Hybrid Microfluidic Devices Suitable for Drug Studies
Harris P; Kaveh J; Kemas AM; Mikaelsson H; Fielden M; Lauschke VM; Shafagh RZ
Article: ADVANCED SCIENCE. 2024;11(18):e2307734
Consequences of Amyloid-β Deficiency for the Liver
Buniatian GH; Schwinghammer U; Tremmel R; Cynis H; Weiss TS; Weiskirchen R; Lauschke VM; Youhanna S; Ramos I; Valcarcel M; Seferyan T; Rahfeld J-U; Rieckmann V; Klein K; Buadze M; Weber V; Kolak V; Gebhardt R; Friedman SL; Mueller UC; Schwab M; Danielyan L
Article: HUMAN GENOMICS. 2024;18(1):40
Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences
Camara MD; Zhou Y; De Sousa TN; Gil JP; Djimde AA; Lauschke VM
Article: GENOME BIOLOGY. 2024;25(1):104
Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Pan L; Parini P; Tremmel R; Loscalzo J; Lauschke V; Maron B; Paci P; Ernberg I; Tan NS; Liao Z; Yin W; Rengarajan S; Li X
Article: ISCIENCE. 2024;27(4):109346
Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia
Di Martino E; Ambikan A; Ramskold D; Umekawa T; Giatrellis S; Vacondio D; Romero AL; Galan MG; Sandberg R; Aden U; Lauschke VM; Neogi U; Blomgren K; Kele J
Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(11):2303561
Compound Absorption in Polymer Devices Impairs the Translatability of Preclinical Safety Assessments
Kemas AM; Shafagh RZ; Taebnia N; Michel M; Preiss L; Hofmann U; Lauschke VM
Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402
Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis
Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Sondergaard JN; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-Andre M; Petersson C; Hagstrom H; Lauschke VM; Archer A; Williams C; Kutter C
Article: BIOTECHNOLOGY JOURNAL. 2024;19(3):e2300684
Proteomic workflows for deep phenotypic profiling of 3D organotypic liver models
Koutsilieri S; Mickols E; Vegvari A; Lauschke VM
Article: BIOTECHNOLOGY JOURNAL. 2024;19(2):e2300587
The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function
Xing C; Kemas A; Mickols E; Klein K; Artursson P; Lauschke VM
Article: NATURE COMMUNICATIONS. 2024;15(1):767
Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function
Lazzeri-Barcelo F; Oliva-Vilarnau N; Baniol M; Leibiger B; Bergmann O; Lauschke VM; Leibiger IB; Moruzzi N; Berggren P-O
Article: DIABETOLOGIA. 2024;67(1):137-155
Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis
Ren L; Charbord J; Chu L; Kemas AM; Bertuzzi M; Mi J; Xing C; Lauschke VM; Andersson O
Article: EMBO JOURNAL. 2023;42(23):e114086
Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection
Krejcova G; Morgantini C; Zemanova H; Lauschke VM; Kovarova J; Kubasek J; Nedbalova P; Kamps-Hughes N; Moos M; Aouadi M; Dolezal T; Bajgar A
Article: ACTA BIOMATERIALIA. 2023;171:336-349
3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation
Wesseler MF; Taebnia N; Harrison S; Youhanna S; Preiss LC; Kemas AM; Vegvari A; Mokry J; Sullivan GJ; Lauschke VM; Larsen NB
Article: NATURE COMMUNICATIONS. 2023;14(1):6785
Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
Monteil V; Kwon H; John L; Salata C; Jonsson G; Vorrink SU; Appelberg S; Youhanna S; Dyczynski M; Leopoldi A; Leeb N; Volz J; Hagelkruys A; Kellner MJ; Devignot S; Michlits G; Foong-Sobis M; Weber F; Lauschke VM; Horn M; Feldmann H; Elling U; Penninger JM; Mirazimi A
Article: NATURE COMMUNICATIONS. 2023;14(1):6243
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
Wright SC; Motso A; Koutsilieri S; Beusch CM; Sabatier P; Berghella A; Blondel-Tepaz E; Mangenot K; Pittarokoilis I; Sismanoglou D-C; Le Gouill C; Olsen JV; Zubarev RA; Lambert NA; Hauser AS; Bouvier M; Lauschke VM
Article: ACS CHEMICAL BIOLOGY. 2023;18(9):1993-2002
Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation
Novak M; Vajrychova M; Koutsilieri S; Sismanoglou D-C; Kobrlova T; Prchal L; Svobodova B; Korabecny J; Zarybnicky T; Raisova-Stuchlikova L; Skalova L; Lauschke VM; Kucera R; Soukup O
Article: NPJ GENOMIC MEDICINE. 2023;8(1):24
Structural variation of the coding and non-coding human pharmacogenome
Tremmel R; Zhou Y; Schwab M; Lauschke VM
Article: BIOCHEMICAL PHARMACOLOGY. 2023;215:115755
Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction
Oliva-Vilarnau N; Vorrink SU; Buettner FA; Heinrich T; Sensbach J; Koscielski I; Wienke D; Petersson C; Perrin D; Lauschke VM
Article: FASEB BIOADVANCES. 2023;5(8):336-353
Two different isoforms of osteopontin modulate myelination and axonal integrity
Nilsson G; Mottahedin A; Zelco A; Lauschke VM; Ek CJ; Song J; Ardalan M; Hua S; Zhang X; Mallard C; Hagberg H; Leavenworth JW; Wang X
Article: NATURE METABOLISM. 2023;5(7):1188-1203
Human resident liver myeloid cells protect against metabolic stress in obesity
Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Soennerborg I; Ma J; Urgard E; Pallett LJ; Hu Y; Fardellas A; Azzimato V; Vankova A; Levi L; Morgantini C; Maini MK; Stal P; Rosshart SP; Coquet JM; Nowak G; Naeslund E; Lauschke VM; Ellis E; Bjoerkstroem NK; Chen P; Aouadi M
Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s363
FRI-388 Liver spheroids engrafted in the anterior chamber of the eye-a novel platform to study hepatic physiology and pathology
Lazzeri-Barcelo F; Vilarnau N; Leibiger B; Lauschke V; Leibiger I; Berggren P-O; Moruzzi N
Article: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2023;80:102057
Next-generation human adipose tissue culture methods
Lauschke VM; Hagberg CE
Article: PHARMACOGENOMICS JOURNAL. 2023;23(2-3):45-49
Meta-analysis of pharmacogenetic clinical decision support systems for the treatment of major depressive disorder
Skryabin V; Rozochkin I; Zastrozhin M; Lauschke V; Franck J; Bryun E; Sychev D
Article: STAR PROTOCOLS. 2023;4(2):102260
Calcium measurements in enzymatically dissociated or mechanically microdissected mouse primary skeletal muscle fibers
Youhanna S; Bruton J; Jardemark K; Westerblad H; Lauschke VM
Article: ACS CHEMICAL BIOLOGY. 2023;18(4):822-836
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum
Tredup C; Ndreshkjana B; Schneider NS; Tjaden A; Kemas AM; Youhanna S; Lauschke VM; Berger B-T; Kraemer A; Berger LM; Roehm S; Knapp S; Farin HF; Mueller S
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2023;113(3):712-723
Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations
Khor CC; Winter S; Sutiman N; Muerdter TE; Chen S; Lim JSL; Li Z; Li J; Sim KS; Ganchev B; Eccles D; Eccles B; Tapper W; Zgheib NKK; Tfayli A; Ng RCH; Yap YS; Lim E; Wong M; Wong NS; Ang PCS; Dent R; Tremmel R; Klein K; Schaeffeler E; Zhou Y; Lauschke VMM; Eichelbaum M; Schwab M; Brauch HBB; Chowbay B; Schroth W
Article: HUMAN GENOMICS. 2023;17(1):15
Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences
Zhou Y; Nevosadova L; Eliasson E; Lauschke VMM
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2023;224:115154
UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes
Novak M; Svobodova B; Konecny J; Kuratkova A; Nevosadova L; Prchal L; Korabecny J; Lauschke VM; Soukup O; Kucera R
Article: THE LANCET. 2023;401(10374):347-356
A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study
Swen JJ; van der Wouden CH; Manson LEN; Abdullah-Koolmees H; Blagec K; Blagus T; Boehringer S; Cambon-Thomsen A; Cecchin E; Cheung K-C; Deneer VHM; Dupui M; Ingelman-Sundberg M; Jonsson S; Joefield-Roka C; Just KS; Karlsson MO; Konta L; Koopmann R; Kriek M; Lehr T; Mitropoulou C; Rial-Sebbag E; Rollinson V; Roncato R; Samwald M; Schaeffeler E; Skokou M; Schwab M; Steinberger D; Stingl JC; Tremmel R; Turner RM; van Rhenen MH; Fajardo CLD; Dolzan V; Patrinos GP; Pirmohamed M; Sunder-Plassmann G; Toffoli G; Guchelaar H-J
Journal article: CURRENT DRUG METABOLISM. 2023;24(2):79
Meet the Associate Editorial Board Member
Lauschke VM
Article: NORDIC JOURNAL OF PSYCHIATRY. 2023;77(1):73-76
Cyp3a4*22 and cyp3a5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome
Skryabin VY; Franck J; Lauschke VM; Zastrozhin MS; Shipitsyn VV; Bryun EA; Sychev DA
Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2023;280:237-260
Challenges Related to the Use of Next-Generation Sequencing for the Optimization of Drug Therapy.
Zhou Y; Lauschke VM
Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2023;21:4361-4369
Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis
Handin N; Yuan D; Olander M; Wegler C; Karlsson C; Jansson-Lofmark R; Hjelmesaeth J; Asberg A; Lauschke VM; Artursson P
Article: ALTEX. 2023;40(3):519-533
Incorporating New Approach Methodologies into Regulatory Nonclinical Pharmaceutical Safety Assessment
Turner J; Pound P; Owen C; Hutchinson I; Hop M; Chau DYS; Silva LVB; Coleman M; Dubourg A; Harries LW; Hutter V; Kenna JG; Lauschke VM; Neuhaus W; Roper C; Watkins PB; Welch J; Alvarez LR; Taylor K
Article: ISCIENCE. 2022;25(12):105654
Enzymatically dissociated muscle fibers display rapid dedifferentiation and impaired mitochondrial calcium control
Gineste C; Youhanna S; Vorrink SU; Henriksson S; Hernandez A; Cheng AJ; Chaillou T; Buttgereit A; Schneidereit D; Friedrich O; Hultenby K; Bruton JD; Ivarsson N; Sandblad L; Lauschke VM; Westerblad H
Article: ISCIENCE. 2022;25(12):105506
Scellseg: A style-aware deep learning tool for adaptive cell instance segmentation by contrastive fine-tuning
Xun D; Chen D; Zhou Y; Lauschke VM; Wang R; Wang Y
Article: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2022;148(12):3293-3302
CFTR reduces the proliferation of lung adenocarcinoma and is a strong predictor of survival in both smokers and non-smokers
Xiao Q; Koutsilieri S; Sismanoglou D-C; Lauschke VM
Article: PHARMACOGENOMICS JOURNAL. 2022;22(5-6):284-293
The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data
Zhou Y; Lauschke VM
Article: ADVANCED SCIENCE. 2022;9(34):e2203368
Bioengineered Pancreas-Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia
Shafagh RZ; Youhanna S; Keulen J; Shen JX; Taebnia N; Preiss LC; Klein K; Buettner FA; Bergqvist M; van der Wijngaart W; Lauschke VM
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;154:113644
Rare genetic variant burden in DPYD predicts severe fluoropyrimidine-related toxicity risk
De Mattia E; Silvestri M; Polesel J; Ecca F; Mezzalira S; Scarabel L; Zhou Y; Roncato R; Lauschke VM; Calza S; Spina M; Puglisi F; Toffoli G; Cecchin E
Article: JOURNAL OF PERSONALIZED MEDICINE. 2022;12(7):1187
CYP2C19 and CYP2D6 Genotypes and Metabolizer Status Distribution in a Bulgarian Psychiatric Cohort
Ivanov HY; Grigorova D; Lauschke VM; Velinov B; Stoychev K; Kyosovska G; Shopov P
Journal article: JOURNAL OF HEPATOLOGY. 2022;77:S665-S666
Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke V; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; v.B. Hjelmborg J; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kahler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Makitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Ramo J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
Article: PHARMACEUTICS. 2022;14(5):944
Genetic Variant ABCC1 rs45511401 Is Associated with Increased Response to Statins in Patients with Familial Hypercholesterolemia
Dagli-Hernandez C; Borges JB; Rodrigues Marcal EDS; Costa de Freitas RC; Mori AA; Goncalves RM; Faludi AA; de Oliveira VF; Ferreira GM; Bastos GM; Zhou Y; Lauschke VM; Cerda A; Hirata MH; Crespo Hirata RD
Article: AAPS JOURNAL. 2022;24(2):41
Multi-Well Array Culture of Primary Human Hepatocyte Spheroids for Clearance Extrapolation of Slowly Metabolized Compounds
Preiss LC; Lauschke VM; Georgi K; Petersson C
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2022;70(3):650-658
Immunogenicity after 6 months of BNT162b2 vaccination in frail or disabled nursing home residents: The COVID-A Study
Salmeron Rios S; Mas Romero M; Cortes Zamora EB; Tabernero Sahuquillo MT; Romero Rizos L; Manuel Sanchez-Jurado P; Sanchez-Nievas G; Blas Senalada JJ; Garcia Nogueras I; Estrella Cazalla JDD; Andres-Pretel F; Romero AM; Lauschke VM; Stebbing J; Abizanda P; Cespedes AA
Article: PHARMACOLOGICAL RESEARCH. 2022;176:106087
Identification and functional validation of novel pharmacogenomic variants using a next-generation sequencing-based approach for clinical pharmacogenomics
Siamoglou S; Koromina M; Hishinuma E; Yamazaki S; Tsermpini E-E; Kordou Z; Fukunaga K; Chantratita W; Zhou Y; Lauschke VM; Mushiroda T; Hiratsuka M; Patrinos GP
Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
An overlooked subset of Cx3cr1^wt/wt microglia in the Cx3cr1^{CreER-Eyfp/wt} mouse has a repopulation advantage over Cx3cr1^{CreER-Eyfp/wt} microglia following microglial depletion
Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
Journal article: EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT. 2022;7(1):39-49
Non-alcoholic fatty liver disease - opportunities for personalized treatment and drug development
Kemas AM; Youhanna S; Lauschke VM
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:337-349
Measuring Glucose Consumption and Gluconeogenesis in 3D Human Tissue Cultures with Nanoliter Input Volumes.
Kemas AM; Lauschke VM
Article: CURRENT DRUG METABOLISM. 2022;23(13):1067-1071
Genetic Testing is Superior Over Endogenous Pharmacometabolomic Markers to Predict Safety of Haloperidol in Patients with Alcohol-induced Psychotic Disorder
Skryabin V; Zastrozhin M; Parkhomenko A; Lauschke VM; Smirnov V; Petukhov A; Pankratenko E; Pozdnyakov S; Koporov S; Denisenko N; Akmalova K; Bryun E; Sychev D
Article: GASTROENTEROLOGY. 2021;161(6):1982-1997.e11
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity
Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX; Miller A; Ellis E; Ryden M; Naslund E; Thorell A; Lauschke VM; Channon KM; Crabtree MJ; Haschemi A; Craige SM; Mori M; Spallotta F; Aouadi M
Article: PHARMACOLOGICAL RESEARCH. 2021;173:105904
The ethnogeographic variability of genetic factors underlying G6PD deficiency
Koromina M; Pandi MT; van der Spek PJ; Patrinos GP; Lauschke VM
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(10):2752-2758
Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia
Abizanda P; Calbo Mayo JM; Mas Romero M; Cortes Zamora EB; Tabernero Sahuquillo MT; Romero Rizos L; Sanchez-Jurado PM; Sanchez-Nievas G; Campayo Escolano C; Ochoa Serrano A; Sanchez-Flor Alfaro V; Lopez Bru R; Gomez Ballesteros C; Caldevilla Bernardo D; Callejas Gonzalez FJ; Andres-Pretel F; Lauschke VM; Stebbing J
Article: SCIENCE ADVANCES. 2021;7(36):eabi6856
Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine
Zhou Y; Arribas GH; Turku A; Juergenson T; Mkrtchian S; Krebs K; Wang Y; Svobodova B; Milani L; Schulte G; Korabecny J; Gastaldello S; Lauschke VM
Article: GENES & DEVELOPMENT. 2021;35(15-16):1190-1207
Single-cell atlas reveals meningeal leukocyte heterogeneity in the developing mouse brain
Zelco A; Borjesson V; de Kanter JK; Lebrero-Fernandez C; Lauschke VM; Rocha-Ferreira E; Nilsson G; Nair S; Svedin P; Bemark M; Hagberg H; Mallard C; Holstege FCP; Wang X
Article: ADVANCED SCIENCE. 2021;8(16):e2100106
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis
Shen JX; Couchet M; Dufau J; de Castro Barbosa T; Ulbrich MH; Helmstadter M; Kemas AM; Zandi Shafagh R; Marques M-A; Hansen JB; Mejhert N; Langin D; Ryden M; Lauschke VM
Article: DRUG METABOLISM AND DISPOSITION. 2021;49(8):668-678
Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells
Preiss LC; Liu R; Hewitt P; Thompson D; Georgi K; Badolo L; Lauschke VM; Petersson C
Article: CURRENT OPINION IN PHARMACOLOGY. 2021;59:11-18
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development
Youhanna S; Wright SC; Lauschke VM
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021;65(7):e0027521-10.1128/aac.00221
Pharmacogene Sequencing of a Gabonese Population with Severe Plasmodium falciparum Malaria Reveals Multiple Novel Variants with Putative Relevance for Antimalarial Treatment
Pernaute-Lau L; Adegnika AA; Zhou Y; Zinsou JF; Gil JP; Krishna S; Kremsner PG; Lauschke VM; Velavan TP
Article: NPJ GENOMIC MEDICINE. 2021;6(1):41
The prevalence, genetic complexity and population-specific founder effects of human autosomal recessive disorders
Xiao Q; Lauschke VM
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(6):1441-1447
Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study
Salmeron Rios S; Mas Romero M; Cortes Zamora EB; Tabernero Sahuquillo MT; Romero Rizos L; Sanchez-Jurado PM; Sanchez-Nievas G; Senalada JJB; Garcia Nogueras I; Estrella Cazalla JDD; Andres-Pretel F; Murillo Romero A; Lauschke VM; Stebbing J; Abizanda P
Article: MAGNESIUM RESEARCH. 2021;34(2):74-83
Magnesium enhances cardiomyocyte proliferation and suppresses cardiac fibrosis induced by chronic ACTH exposure in rats
Petrovic J; Labudovic-Borovic M; Vorrink SU; Lauschke VM; Pejuskovic B; Pesic V
Article: AMERICAN JOURNAL OF PHYSIOLOGY - CELL PHYSIOLOGY. 2021;320(5):C822-C841
In vitro and ex vivo models of adipocytes
Dufau J; Shen JX; Couchet M; Barbosa TDC; Mejhert N; Massier L; Griseti E; Mouisel E; Amri E-Z; Lauschke VM; Ryden M; Langin D
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2021;108(3):446-457
Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
Wyckelsma VL; Venckunas T; Houweling PJ; Schlittler M; Lauschke VM; Tiong CF; Wood HD; Ivarsson N; Paulauskas H; Eimantas N; Andersson DC; North KN; Brazaitis M; Westerblad H
Article: THE FASEB JOURNAL. 2021;35(3):e21305
Insulin-dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific glucose sensor with nanoliter input volume
Kemas AM; Youhanna S; Shafagh RZ; Lauschke VM
Article: EMBO MOLECULAR MEDICINE. 2021;13(1):e13426
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection
Monteil V; Dyczynski M; Lauschke VM; Kwon H; Wirnsberger G; Youhanna S; Zhang H; Slutsky AS; Hurtado del Pozo C; Horn M; Montserrat N; Penninger JM; Mirazimi A
Journal article: PHARMACOGENOMICS RESEARCH AND PERSONALIZED MEDICINE. 2021;0(0):0
Should we test for SLCO1B1 genotype before prescribing statins? A discussion of clinical trial results
Zhou Y; Lauschke VM
Article: SCIENCE ADVANCES. 2021;7(1):eabe4724
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
Stebbing J; Nievas GS; Falcone M; Youhanna S; Richardson P; Ottaviani S; Shen JX; Sommerauer C; Tiseo G; Ghiadoni L; Virdis A; Monzani F; Rizos LR; Forfori F; Avendano-Cespedes A; De Marco S; Carrozzi L; Lena F; Sanchez-Jurado PM; Lacerenza LG; Cesira N; Caldevilla-Bernardo D; Perrella A; Niccoli L; Mendez LS; Matarrese D; Goletti D; Tan Y-J; Monteil V; Dranitsaris G; Cantini F; Farcomeni A; Dutta S; Burley SK; Zhang H; Pistello M; Li W; Romero MM; Pretel FA; Simon-Talero RS; Garcia-Molina R; Kutter C; Felce JH; Nizami ZF; Miklosi AG; Penninger JM; Menichetti F; Mirazimi A; Abizanda P; Lauschke VM
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2021;109(1):160-174
Global Frequencies of Clinically ImportantHLAAlleles and Their Implications For the Cost-Effectiveness of Preemptive Pharmacogenetic Testing
Zhou Y; Krebs K; Milani L; Lauschke VM
Article: ACS APPLIED BIO MATERIALS. 2020;3(12):8757-8767
Facile Nanoimprinting of Robust High-Aspect-Ratio Nanostructures for Human Cell Biomechanics
Shafagh RZ; Shen JX; Youhanna S; Guo W; Lauschke VM; van der Wijngaart W; Haraldsson T
Article: BRITISH JOURNAL OF CANCER. 2020;123(12):1782-1789
Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier
Zhou Y; Dagli Hernandez C; Lauschke VM
Article: EXPERIMENTAL CELL RESEARCH. 2020;395(2):112234
High glucose-induced oxidative stress accelerates myogenesis by altering SUMO reactions
Liu X; Heras G; Lauschke VM; Mi J; Tian G; Gastaldello S
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2020;108(4):844-855
Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes
Hendriks DFG; Vorrink SU; Smutny T; Sim SC; Nordling A; Ullah S; Kumondai M; Jones BC; Johansson I; Andersson TB; Lauschke VM; Ingelman-Sundberg M
Article: EMBO MOLECULAR MEDICINE. 2020;12(8):e12697
Mechanism of baricitinib supports artificial intelligence-predicted testing inCOVID-19 patients
Stebbing J; Krishnan V; de Bono S; Ottaviani S; Casalini G; Richardson PJ; Monteil V; Lauschke VM; Mirazimi A; Youhanna S; Tan Y-J; Baldanti F; Sarasini A; Terres JAR; Nickoloff BJ; Higgs RE; Rocha G; Byers NL; Schlichting DE; Nirula A; Cardoso A; Corbellino M
Article: ADVANCED SCIENCE. 2020;7(15):2000248
A 3D Cell Culture Model Identifies Wnt/β-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration
Oliva-Vilarnau N; Vorrink SU; Ingelman-Sundberg M; Lauschke VM
Article: CELL REPORTS. 2020;31(9):107699
Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain
Osman AM; Sun Y; Burns TC; He L; Kee N; Oliva-Vilarnau N; Alevyzaki A; Zhou K; Louhivuori L; Uhlen P; Hedlund E; Betsholtz C; Lauschke VM; Kele J; Blomgren K
Article: HUMAN MUTATION. 2020;41(6):1112-1122
Documentation of clinically relevant genomic biomarker allele frequencies in the next-generation FINDbase worldwide database
Kounelis F; Kanterakis A; Kanavos A; Pandi M-T; Kordou Z; Manusama O; Vonitsanos G; Katsila T; Tsermpini E-E; Lauschke VM; Koromina M; van der Spek PJ; Patrinos GP
Article: HUMAN GENETICS. 2020;139(5):623-646
Ethnogeographic and inter-individual variability of human ABC transporters
Xiao Q; Zhou Y; Lauschke VM
Article: INTERNATIONAL JOURNAL OF CANCER. 2020;146(9):2475-2487
Germline variant burden in multidrug resistance transporters is a therapy-specific predictor of survival in breast cancer patients
Xiao Q; Zhou Y; Winter S; Buettner F; Schaeffeler E; Schwab M; Lauschke VM
Article: MOLECULAR PHARMACEUTICS. 2020;17(4):1170-1181
In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na⁺-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1)
Russell LE; Zhou Y; Lauschke VM; Kim RB
Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(532):eaaw9709
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance
Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C; Li X; Shen JX; Akbar N; Haag L; Ellis E; Walhen K; Naslund E; Thorell A; Choudhury RP; Lauschke VM; Ryden M; Craige SM; Aouadi M
Article: THE FASEB JOURNAL. 2020;34(2):2269-2286
Expression of SUMO enzymes is fiber type dependent in skeletal muscles and is dysregulated in muscle disuse
Namuduri AV; Heras G; Lauschke VM; Vitadello M; Traini L; Cacciani N; Gorza L; Gastaldello S
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(1):88-94
Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe
Petrovic J; Pesic V; Lauschke VM
Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:52-58
Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition
Zhou Y; Lauschke VM
Article: HUMAN GENETICS. 2019;138(11-12):1359-1377
The genetic landscape of the human solute carrier (SLC) transporter superfamily
Schaller L; Lauschke VM
Article: PHARMACOGENOMICS. 2019;20(15):1085-1092
CYP3A5 is unlikely to mediate anticancer drug resistance in hepatocellular carcinoma
Lauschke VM; Nordling A; Zhou Y; Fontalva S; Barragan I; Ingelman-Sundberg M
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2019;106(4):866-873
Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing
van der Wouden CH; van Rhenen MH; Jama WOM; Ingelman-Sundberg M; Lauschke VM; Konta L; Schwab M; Swen JJ; Guchelaar H-J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39(7):1432-1447
Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling
Jensen LD; Hot B; Ramskold D; Germano RFV; Yokota C; Giatrellis S; Lauschke VM; Hubmacher D; Li MX; Hupe M; Arnold TD; Sandberg R; Frisen J; Trusohamn M; Martowicz A; Wisniewska-Kruk J; Nyqvist D; Adams RH; Apte SS; Vanhollebeke B; Stenman JM; Kele J
Article: GENETICS IN MEDICINE. 2019;21(6):1345-1354
Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions
Reisberg S; Krebs K; Lepamets M; Kals M; Magi R; Metsalu K; Lauschke VM; Vilo J; Milani L
Article: PHARMACOGENOMICS JOURNAL. 2019;19(2):115-126
An optimized prediction framework to assess the functional impact of pharmacogenetic variants
Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke VM
Article: NATURE METABOLISM. 2019;1(4):445-459
Liver macrophages regulate systemic metabolism through non-inflammatory factors
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2019;130:65-77
Prediction of drug response and adverse drug reactions: From twin studies to Next Generation Sequencing
Lauschke VM; Ingelman-Sundberg M
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27(3):442-454
Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records
Tasa T; Krebs K; Kals M; Magi R; Lauschke VM; Haller T; Puurand T; Remm M; Esko T; Metspalu A; Vilo J; Milani L
Article: PHARMACOLOGICAL RESEARCH. 2019;139:550-559
Genetic variability and population diversity of the human SLCO (OATP) transporter family
Zhang B; Lauschke VM
Article: DATABASE : THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION. 2019;2019:baz085
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Brown P; Tan A-C; El-Esawi MA; Liehr T; Blanck O; Gladue DP; Almeida GMF; Cernava T; Sorzano CO; Yeung AWK; Engel MS; Chandrasekaran AR; Muth T; Staege MS; Daulatabad SV; Widera D; Zhang J; Meule A; Honjo K; Pourret O; Yin C-C; Zhang Z; Cascella M; Flegel WA; Goodyear CS; van Raaij MJ; Bukowy-Bieryllo Z; Campana LG; Kurniawan NA; Lalaouna D; Huttner FJ; Ammerman BA; Ehret F; Cobine PA; Tan E-C; Han H; Xia W; McCrum C; Dings RPM; Marinello F; Nilsson H; Nixon B; Voskarides K; Yang L; Costa VD; Bengtsson-Palme J; Bradshaw W; Grimm DG; Kumar N; Martis E; Prieto D; Sabnis SC; Amer SEDR; Liew AWC; Perco P; Rahimi F; Riva G; Zhang C; Devkota HP; Ogami K; Basharat Z; Fierz W; Siebers R; Tan K-H; Boehme KA; Brenneisen P; Brown JAL; Dalrymple BP; Harvey DJ; Ng G; Werten S; Bleackley M; Dai Z; Dhariwal R; Gelfer Y; Hartmann MD; Miotla P; Tamaian R; Govender P; Gurney-Champion OJ; Kauppila JH; Zhang X; Echeverria N; Subhash S; Sallmon H; Tofani M; Bae T; Bosch O; Cuiv PO; Danchin A; Diouf B; Eerola T; 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Ducommun B; Duijf PHG; Epp T; Eskelinen E-L; Fallah M; Farber DB; Fernandez-Triana J; Feyerabend F; Florio T; Friebe M; Furuta S; Gabrielsen M; Gruber J; Grybos M; Han Q; Heinrich M; Helantera H; Huber M; Jeltsch A; Jiang F; Josse C; Jurman G; Kamiya H; de Keersmaecker K; Kristiansson E; de Leeuw F-E; Li J; Liang S; Lopez-Escamez JA; Lopez-Ruiz FJ; Marchbank KJ; Marschalek R; Martin CS; Miele AE; Montagutelli X; Morcillo E; Nicoletti R; Niehof M; O'Toole R; Ohtomo T; Oster H; Palma J-A; Paterson R; Peifer M; Portilla M; Portillo MC; Pritchard AL; Pusch S; Raghava GPS; Roberts NJ; Ross K; Schuele B; Sergeant K; Shen J; Stella A; Sukocheva O; Uversky VN; Vanneste S; Villet MH; Viveiros M; Vorholt JA; Weinstock C; Yamato M; Zabetakis I; Zhao X; Ziegler A; Aizat WM; Atlas L; Bridges KM; Chakraborty S; Deschodt M; Domingues HS; Esfahlani SS; Falk S; Guisado JL; Kane NC; Kueberuwa G; Lau CL; Liang D; Liu E; Luu AM; Ma C; Ma L; Moyer R; Norris AD; Panthee S; Parsons JR; Peng Y; Pinto IM; Reschke CR; Sillanpaa E; Stewart CJ; Uhle F; Yang H; Zhou K; Zhu S; Ashry M; Bergsland N; Berthold M; Chen C-E; Colella V; Cuypers M; Eskew EA; Fan X; Gajda M; Gonzalezlez-Prendes R; Goodin A; Graham EB; Groen EJN; Gutierrez-Sacristan A; Habes M; Heffler E; Higginbottom DB; Janzen T; Jayaraman J; Jibb LA; Jongen S; Kinyanjui T; Koleva-Kolarova RG; Li Z; Liu Y-P; Lund BA; Lussier AA; Ma L; Mier P; Moore MD; Nagler K; Orme MW; Pearson JA; Prajapati AS; Saito Y; Troder SE; Uchendu F; Verloh N; Voutchkova DD; Abu-Zaid A; Bakkach J; Baumert P; Dono M; Hanson J; Herbelet S; Hobbs E; Kulkarni A; Kumar N; Liu S; Loft ND; Reddan T; Senghore T; Vindin H; Xu H; Bannon R; Chen B; Cheung JTK; Cooper J; Esnakul AK; Feghali KA; Ghelardi E; Gnasso A; Horbar J; Lai HM; Li J; Ma L; Ma R; Pan Z; Peres MA; Pranata R; Seow E; Sydes M; Testoni I; Westermair AL; Yang Y; Afnan M; Albiol J; Albuquerque LG; Amiya E; Amorim RM; An Q; Andersen SU; Aplin JD; Argyropoulos C; Asmann YW; Assaeed AM; Atanasov AG; Atchison DA; Avery SV; 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Karp NA; Kelly R; Kenna R; Kennedy J; Kersten B; Khalaf RA; Khalid JM; Khatlani T; Khider T; Kijanka GS; King SRB; Kluz T; Knox P; Kobayashi T; Koch K-W; Kohonen-Corish MRJ; Kong X; Konkle-Parker D; Korpela KM; Kostrikis LG; Kraiczy P; Kratz H; Krause G; Krebsbach PH; Kristensen SR; Kumari P; Kunimatsu A; Kurdak H; Kwon YD; Lachat C; Lagisz M; Laky B; Lammerding J; Lange M; Larrosa M; Laslett AL; LeClair EE; Lee K-W; Lee M-Y; Lee M-S; Li G; Li J; Lieb K; Lim YY; Lindsey ML; Line P-D; Liu D; Liu F; Liu H; Liu H; Lloyd VK; Lo T-W; Locci E; Loidl J; Lorenzen J; Lorkowski S; Lovell NH; Lu H; Lu W; Lu Z; Luengo GS; Lundh L-G; Lysy PA; Mabb A; Mack HG; Mackey DA; Mahdavi SR; Maher P; Maher T; Maity SN; Malgrange B; Mamoulakis C; Mangoni AA; Manke T; Manstead ASR; Mantalaris A; Marsal J; Marschall H-U; Martin FL; Martinez-Raga J; Martinez-Salas E; Mathieu D; Matsui Y; Maza E; McCutcheon JE; Mckay GJ; McMillan B; McMillan N; Meads C; Medina L; Merrick BA; Metzger DW; Meunier FA; Michaelis M; Micheau O; Mihara H; Mintz EM; Mizukami T; Moalic Y; Mohapatra DP; Monteiro A; Montes M; Moran JV; Morozov SY; Mort M; Murai N; Murphy DJ; Murphy SK; Murray SA; Naganawa S; Nammi S; Nasios G; Natoli RM; Nguyen F; Nicol C; van Nieuwerburgh F; Nilsen EB; Nobile CJ; O'Mahony M; Ohlsson S; Olatunbosun O; Olofsson P; Ortiz A; Ostrikov K; Otto S; Outeiro TF; Ouyang S; Paganoni S; Page A; Palm C; Paradies Y; Parsons MH; Parsons N; Pascal P; Paul E; Peckham M; Pedemonte N; Pellizzon MA; Petrelli M; Pichugin A; Pinto CJC; Plevris JN; Pollesello P; Polz M; Ponti G; Porcelli P; Prince M; Quinn GP; Quinn TJ; Ramula S; Rappsilber J; Rehfeldt F; Reiling JH; Remacle C; Rezaei M; Riddick EW; Ritter U; Roach NW; Roberts DD; Robles G; Rodrigues T; Rodriguez C; Roislien J; Roobol MJ; Rowe JA; Ruepp A; van Ruitenbeek J; Rust P; Saad S; Sack GH; Santos M; Saudemont A; Sava G; Schrading S; Schramm A; Schreiber M; Schuler S; Schymkowitz J; Sczyrba A; Seib KL; Shi H-P; Shimada T; Shin J-S; Shortt C; Silveyra P; Skinner D; Small I; Smeets PAM; So P-W; Solano F; Sonenshine DE; Song J; Southall T; Speakman JR; Srinivasan MV; Stabile LP; Stasiak A; Steadman KJ; Stein N; Stephens AW; Stewart DI; Stine K; Storlazzi C; Stoynova NV; Strzalka W; Suarez OM; Sultana T; Sumant AV; Summers MJ; Sun G; Tacon P; Tanaka K; Tang H; Tanino Y; Targett-Adams P; Tayebi M; Tayyem R; Tebbe CC; Telfer EE; Tempel W; Teodorczyk-Injeyan JA; Thijs G; Thorne S; Thrift AG; Tiffon C; Tinnefeld P; Tjahjono DH; Tolle F; Toth E; del Tredici AL; Tsapas A; Tsirigotis K; Turak A; Tzotzos G; Udo EE; Utsumi T; Vaidyanathan S; Vaillant M; Valsesia A; Vandenbroucke RE; Veiga FH; Vendrell M; Vesk PA; Vickers P; Victor VM; Villemur R; Vohl M-C; Voolstra CR; Vuillemin A; Wakelin S; Waldron L; Walsh LJ; Wang AY; Wang F; Wang Y; Watanabe Y; Weigert A; Wen J-C; Wham C; White EP; Wiener J; Wilharm G; Wilkinson S; Willmann R; Wilson C; Wirth B; Wojan TR; Wolff M; Wong BM; Wu T-W; Wuerbel H; Xiao X; Xu D; Xu JW; Xu J; Xue B; Yalcin S; Yan H; Yang E-C; Yang S; Yang W; Ye Y; Ye Z-Q; Yli-Kauhaluoma J; Yoneyama H; Yu Y; Yuan G-C; Yuh C-H; Zaccolo M; Zeng C; Zevnik B; Zhang C; Zhang L; Zhang L; Zhang Y; Zhang Y; Zhang Z; Zhang Z-Y; Zhao Y; Zhou M; Zuberbier T; Aanei CM; Ahmad R; Al-Lawama M; Alanio A; Allardyce J; Alonso-Caneiro D; Atack JM; Baier D; Bansal A; Benezeth Y; Berbesque C; Berrevoet F; Biedermann PHW; Bijleveld E; Bittner F; Blombach F; Van den Bos W; Boudreau SA; Bramoweth AD; Braubach O; Cai Y; Campbell M; Cao Z; Catry T; Chen X; Cheng S; Chung H-J; Chavez-Fumagalli MA; Conway A; Costa BM; Cyr N; Dean LT; Denzel MS; Dlamini SV; Dudley KJ; Dufies M; Ecke T; Eckweiler D; Eixarch E; El-Adawy H; Emmrich JV; Eustace AJ; Falter-Wagner CM; Fuss J; Gao J; Gill MR; Gloyn L; Goggs R; Govinden U; Greene G; Greiff V; Grundle DS; Gruneberg P; Gumede N; Haore G; Harrison P; Hoenner X; Hojsgaard D; Hori H; Ikonomopoulou MP; Jeurissen P; Johnson DM; Kabra D; Kamagata K; Karmakar C; Kasian O; Kaye LK; Khan MM; Kim Y-M; Kish JK; Kobold S; Kohanbash G; Kohls G; Kugler J-M; Kumar G; Lacy-Colson J; Latif A; Lauschke VM; Li B; Lim CJ; Liu F; Liu X; Lu J-J; Lu Q; Mahavadi P; Marzocchi U; McGarrigle CA; van Meerten T; Min R; Moal I; Molari M; Molleman L; Mondal SR; Van de Mortel T; Moss WN; Moultos OA; Mukherjee M; Nakayama K; Narayan E; Navaratnarajah; Neumann P-A; Nie J; Nie Y; Niemeyer F; Nolan F; Nwaiwu O; Oldenmenger WH; Olumayede E; Ou J; Pallebage-Gamarallage M; Pearce SP; Pelkonen T; Pelleri MC; Pereira JL; Pheko M; Pinto KA; Piovesan A; Pluess M; Podolsky IM; Prescott J; Qi D; Qi X; Raikou VD; Ranft A; Rhodes J; Rotge J-Y; Rowe AD; Saggar M; Schuon RA; Shahid S; Shalchyan V; Shirvalkar P; Shiryayev O; Singh J; Smout MJ; Soares A; Song C; Srivastava K; Srivastava RK; Sun J; Szabo A; Szymanski W; Tai CNP; Takeuchi H; Tanadini-Lang S; Tang F; Tao W; Theron G; Tian CF; Tian Y-S; Tuttle LM; Valenti A; Verlot P; Walker M; Wang J; Welter D; Winslade M; Wu D; Wu Y-R; Xiao H; Xu B; Xu J; Xu Z; Yang D; Yang M; Yankilevich P; You Y; Yu C; Zhan J; Zhang G; Zhang K; Zhang T; Zhang Y; Zhao G; Zhao J; Zhou X; Zhu Z; Ajani PA; Anazodo UC; Bagloee SA; Bail K; Bar I; Bathelt J; Benkeser D; Bernier ML; Blanchard AM; Boakye DW; Bonatsos V; Boon MH; Bouboulis G; Bromfield E; Brown J; Bul KCM; Burton KJ; Butkowski EG; Carroll G; Chao F; Charrier EE; Chen X; Chen Y-C; Chenguang; Choi JR; Christoffersen T; Comel JC; Cosse C; Cui Y; van Dessel P; Dhaval; Diodato D; Duffey M; Dutt A; Egea LG; El-Said M; Faye M; Fernandez-Fernandez B; Foley KG; Founou LL; Fu F; Gadelkareem RA; Galimov E; Garip G; Gemmill A; Gouil Q; Grey J; Gridneva Z; Grothe MJ; Grebert T; Guerrero F; Guignard L; Haenssgen MJ; Hasler D; Holgate JY; Huang A; Hulse-Kemp AM; Jean-Quartier C; Jeon S-M; Jia Y; Jutzeler C; Kalatzis P; Karim M; Karsay K; Keitel A; Kempe A; Keown JR; Khoo CM; Khwaja N; Kievit RA; Kosanic A; Koutoukidis DA; Kramer P; Kumar D; Kirag N; Lanza G; Le TD; Leem JW; Leightley D; Leite A; Lercher L; Li Y; Lim R; Lima LRA; Lin L; Ling T; Liu Y; Liu Z; Lu Y; Lum FM; Luo H; Machhi J; Macleod A; Macwan I; Madala HR; Madani N; de Maio N; Makowiecki K; Mallinson DJ; Margelyte R; Maria C; Markonis Y; Marsili L; Mavoa S; McWilliams L; Megersa M; Mendes CSM; Menichetti J; Mercieca-Bebber R; Miller JJ; Minde D-PM; Minges A; Mishra E; Mishra VR; Moores C; Morrice N; Moskalensky AE; Navarin N; Negera E; Nolet P; Nordberg A; Norden R; Nowicki JP; Olova N; Olszewski P; Onzima R; Pan C-L; Park C; Park DI; Park S; Patil CD; Pedro SA; Perry SR; Peter J; Peterson BM; Pezzuolo A; Pozdnyakov I; Qian S; Qin L; Rafe A; Raote I; Raza A; Rebl H; Refai O; Regan T; Richa T; Richardson MF; Robinson KR; Rossoni L; Rouet R; Safaei S; Schneeberger PHH; Schwotzer D; Sebastian A; Selinski J; Seltmann S; Sha F; Shalev N; Shang J-L; Singer J; Singh M; Smith T; Solomon-Moore E; Song L; Soraggi S; Stanley R; Steckhan N; Strobl F; Subissi L; Supriyanto I; Surve CR; Suzuki T; Syme C; Sorelius K; Tang Y; Tantawy M; Tennakoon S; Teseo S; Toelzer C; Tomov N; Tovar M; Tran L; Tripathi S; Tuladhar AM; Ukubuiwe AC; Ung COL; Valgepea K; Vatanparast H; Vidal A; Wang F; Wang Q; Watari R; Webster R; Webster R; Wei J; Wibowo D; Wingenbach TSH; Xavier RM; Xiao S; Xiong P; Xu S; Xu S; Yao R; Yao W; Yin Q; Yu Y; Zaitsu M; Zeineb Z; Zhan X-Y; Zhang J; Zhang R; Zhang W; Zhang X; Zheng S; Zhou B; Zhou X; Ahmad H; Akinwumi SA; Albery GF; Alhowimel A; Ali J; Alshehri M; Alsuhaibani M; Anikin A; Azubuike SO; Bach-Mortensen A; Baltiansky L; Bartas M; Belachew KY; Bhardwaj V; Binder K; Bland NS; Boah M; Bullen B; Calabro GE; Callahan TJ; Cao B; Chalmers K; Chang W; Che Z; Chen ATY; Chen H; Chen H; Chen Y; Chen Z; Choi Y; Chowdhury MAK; Christensen MR; Cooke RSC; Cottini M; Covington NV; Cunningham C; Delarocque J; Devos L; Dhar AR; Ding K-F; Dong K; Dong Z; Dreyer N; Ekstrand C; Fardet T; Feleke BE; Feurer T; Freitas A; Gao T; Asefa NG; Giganti F; Grabowski P; Guerra-Mora JR; Guo C; Guo X; Gupta H; He S; Heijne M; Heinemann S; Hogrebe A; Huang Z; Iskander-Rizk S; Iyer LM; Jahan Y; James AS; Joel E; Joffroy B; Jegousse C; Kambondo G; Karnati P; Kaya C; Ke A; Kelly D; Kickert R; Kidibule PE; Kieselmann JP; Kim HJ; Kitazawa T; Lamberts A; Li Y; Liang H; Linn SN; Litfin T; Liusuo W; Lygirou V; Mahato AK; Mai Z-M; Major RW; Mali S; Mallis P; Mao W; Mao W; Marvin-Dowle K; Marvin-Dowle K; Mason LD; Merideth B; Merino-Plaza MJ; Merlaen B; Messina R; Mishra AK; Muhammad J; Musinguzi C; Nanou A; Naqash A; Nguyen JT; Nguyen TTH; Ni D; Nida; Notcovich S; Ohst B; Ollivier QR; Osses DF; Peng X; Plantinga A; Pulia M; Rafiq M; Raman A; Raucher-Chene D; Rawski R; Ray A; Razak LA; Rudolf K; Rusch P; Sadoine ML; Schmidt A; Schurr R; Searles S; Sharma S; Sheehan B; Shi C; Shohayeb B; Sommerlad A; Strehlow J; Sun X; Sundar R; Taherzadeh G; Tahir NDM; Tang J; Testa J; Tian Z; Tingting Q; Verheijen GP; Vickstrom C; Wang T; Wang X; Wang Z; Wei P; Wilson A; Wyart; Yassine A-A; Yousefzadeh A; Zare A; Zeng Z; Zhang C; Zhang H; Zhang L; Zhang T; Zhang W; Zhang Z; Zhou J; Zhu D; Adamo V; Adeyemo AA; Aggelidou M; Al-Owaifeer AM; Al-Riyami AZ; Alzghari SK; Andersen V; Angus K; Asaduzzaman M; Asady H; Ato D; Bai X; Baines RL; Ballantyne M; Ban B; Beck J; Ben-Nafa W; Black E; Blancher A; Blankstein R; Bodagh N; Borges PAV; Brooks A; Brox-Ponce J; Brunetti A; Canham CD; Carninci P; Carvajal R; Chang SC; Chao J; Chatterjee P; Chen H; Chen Y-C; Chhatriwalla AK; Chikowe I; Chuang T-J; Collevatti RG; Valera-Cornejo DA; Cuenda A; Dao M; Dauga D; Deng Z; Devkota K; Doan LV; Elewa YHA; Fan D; Faruk M; Feifei S; Ferguson TS; Fleres F; Foster EJ; Foster CS; Furer T; Gao Y; Garcia-Rivera EJ; Gazdar A; George RB; Ghosh S; Gianchecchi E; Gleason JM; Hackshaw A; Hall A; Hall R; Harper P; Hogg WE; Huang G; Hunter KE; IJzerman AP; Jesus C; Jian G; Lewis JSJ; Kanj SS; Kaur H; Kelly S; Kheir F; Kichatova VS; Kiyani M; Klein R; Kovesi T; Kraschnewski JL; Kumar AP; Labutin D; Lazo-Langner A; Leclercq G; Li M; Li Q; Li T; Li Y; Liao W-T; Liao Z-Y; Lin J; Lizer J; Lobreglio G; Lowies C; Lu C; Majeed H; Martin A; Martinez-Sobrido L; Meresh E; Middelveen M; Mohebbi A; Mota J; Mozaheb Z; Muyaya L; Nandhakumar A; Ng SHX; Obeidat M; Oh D-H; Owais M; Pace-Asciak P; Panwar A; Park C; Patterson C; Penagos-Tabaree F; Pianosi PT; Pinzi V; Pridans C; Psaroulaki A; Pujala RK; Pulido-Arjona L; Qi P-F; Rahman P; Rai NK; Rassaf T; Refardt J; Ricciardi W; Riess O; Rovas A; Sacks FM; Saleh S; Sampson C; Schmutz A; Sepanski R; Sharma N; Singh M; Spearman P; Subramaniapillai M; Swali R; Tan CM; Tellechea JI; Thomas L-M; Tong X; Veys R; Vitriol V; Wang H-D; Wang J; Wang J; Waugh J; Webb SA; Williams BA; Workman AD; Xiang T; Xie L-X; Xu J; Xu T; Yang C; Yoon JG; Yuan CM; Zaritsky A; Zhang Y; Zhao H; Zuckerman H; Lyu R; Pullan W; Zhou Y
Article: JOURNAL OF LIPID RESEARCH. 2018;59(10):1987-2000
Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk
Zhou Y; Magi R; Milani L; Lauschke VM
Article: SCIENTIFIC REPORTS. 2018;8(1):14297
Human hepatic 3D spheroids as a model for steatosis and insulin resistance
Kozyra M; Johansson I; Nordling A; Ullah S; Lauschke VM; Ingelman-Sundberg M
Article: PHARMACOGENOMICS. 2018;19(14):1133-1138
Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions
Ingelman-Sundberg M; Lauschke VM
Article: JOURNAL OF MEDICAL GENETICS. 2018;55(9):617-627
Comprehensive overview of the pharmacogenetic diversity in Ashkenazi Jews
Zhou Y; Lauschke VM
Article: PHARMACOGENOMICS. 2018;19(12):931-936
Functional characterization of CYP2D7 gene variants
Jukic MM; Lauschke VM; Saito T; Hiratsuka M; Ingelman-Sundberg M
Article: TOXICOLOGICAL SCIENCES. 2018;163(2):655-665
Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions
Vorrink SU; Zhou Y; Ingelman-Sundberg M; Lauschke VM
Article: GENETICS IN MEDICINE. 2018;20(6):622-629
Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics
Santos M; Niemi M; Hiratsuka M; Kumondai M; Ingelman-Sundberg M; Lauschke VM; Rodriguez-Antona C
Article: HUMAN GENOMICS. 2018;12(1):26
Integrating rare genetic variants into pharmacogenetic drug response predictions
Ingelman-Sundberg M; Mkrtchian S; Zhou Y; Lauschke VM
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2018;103(5):745-748
How to Consider Rare Genetic Variants in Personalized Drug Therapy
Lauschke VM; Ingelman-Sundberg M
Article: TOXICOLOGICAL SCIENCES. 2018;162(2):655-666
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Bell CC; Dankers ACA; Lauschke VM; Sison-Young R; Jenkins R; Rowe C; Goldring CE; Park K; Regan SL; Walker T; Schofield C; Baze A; Foster AJ; Williams DP; van de Ven AWM; Jacobs F; van Houdt J; Lahteenmaki T; Snoeys J; Juhila S; Richert L; Ingelman-Sundberg M
Article: APPLIED IN VITRO TOXICOLOGY. 2018;4(1):1-12
Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues.
Messner S; Fredriksson L; Lauschke VM; Roessger K; Escher C; Bober M; Kelm JM; Ingelman-Sundberg M; Moritz W
Article: CELL. 2018;172(5):1079-1090.e12
Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation
Sonnen KF; Lauschke VM; Uraji J; Falk HJ; Petersen Y; Funk MC; Beaupeux M; Francois P; Merten CA; Aulehla A
Journal article: PROCEEDINGS FOR ANNUAL MEETING OF THE JAPANESE PHARMACOLOGICAL SOCIETY. 2018;WCP2018(0):po4-9-16
Prediction of drug-induced hepatotoxicity using long-term stable primary hepatic 3D spheroid cultures
Vorrink SU; Zhou Y; Ingelman-Sundberg M; Lauschke VM
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2017;102(4):688-700
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects
Zhou Y; Ingelman-Sundberg M; Lauschke VM
Article: THE FASEB JOURNAL. 2017;31(6):2696-2708
Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics
Vorrink SU; Ullah S; Schmidt S; Nandania J; Velagapudi V; Beck O; Ingelman-Sundberg M; Lauschke VM
Article: DRUG METABOLISM AND DISPOSITION. 2017;45(4):419-429
Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
Bell CC; Lauschke VM; Vorrink SU; Palmgren H; Duffin R; Andersson TB; Ingelman-Sundberg M
Article: ARCHIVES OF TOXICOLOGY. 2017;91(3):1385-1400
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young RL; Lauschke VM; Johann E; Alexandre E; Antherieu S; Aerts H; Gerets HHJ; Labbe G; Hoet D; Dorau M; Schofield CA; Lovatt CA; Holder JC; Stahl SH; Richert L; Kitteringham NR; Jones RP; Elmasry M; Weaver RJ; Hewitt PG; Ingelman-Sundberg M; Goldring CE; Park BK
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;482(3):399-407
The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration
Lauschke VM; Mkrtchian S; Ingelman-Sundberg M
Article: GENETICS IN MEDICINE. 2017;19(1):20-29
Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response
Kozyra M; Ingelman-Sundberg M; Lauschke VM
Article: HEPATOLOGY. 2016;64(5):1743-1756
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Lauschke VM; Vorrink SU; Moro SML; Rezayee F; Nordling A; Hendriks DFG; Bell CC; Sison-Young R; Park BK; Goldring CE; Ellis E; Johansson I; Mkrtchian S; Andersson TB; Ingelman-Sundberg M
Article: NUCLEIC ACIDS RESEARCH (NAR). 2016;44(14):6756-6769
Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression
Ivanov M; Kals M; Lauschke V; Barragan I; Ewels P; Kaller M; Axelsson T; Lehtio J; Milani L; Ingelman-Sundberg M
Article: PHARMACOGENOMICS. 2016;17(8):917-924
Requirements for comprehensive pharmacogenetic genotyping platforms
Lauschke VM; Ingelman-Sundberg M
Article: SCIENTIFIC REPORTS. 2016;6:25187
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell CC; Hendriks DFG; Moro SML; Ellis E; Walsh J; Renblom A; Puigvert LF; Dankers ACA; Jacobs F; Snoeys J; Sison-Young RL; Jenkins RE; Nordling A; Mkrtchian S; Park BK; Kitteringham NR; Goldring CEP; Lauschke VM; Ingelman-Sundberg M
Article: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2016;99(2):172-185
Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting
Kalman LV; Agundez JAG; Appell ML; Black JL; Bell GC; Boukouvala S; Bruckner C; Bruford E; Caudle K; Coulthard SA; Daly AK; Del Tredici AL; den Dunnen JT; Drozda K; Everts RE; Flockhart D; Freimuth RR; Gaedigk A; Hachad H; Hartshorne T; Ingelman-Sundberg M; Klein TE; Lauschke VM; Maglott DR; McLeod HL; McMillin GA; Meyer UA; Mueller DJ; Nickerson DA; Oetting WS; Pacanowski M; Pratt VM; Relling MV; Roberts A; Rubinstein WS; Sangkuhl K; Schwab M; Scott SA; Sim SC; Thirumaran RK; Toji LH; Tyndale RF; van Schaik RHN; Whirl-Carrillo M; Yeo KTJ; Zanger UM
Article: PHARMACOGENETICS AND GENOMICS. 2015;25(12):584-594
Genetic variation in the human cytochrome P450 supergene family
Fujikura K; Ingelman-Sundberg M; Lauschke VM
Article: NATURE. 2013;493(7430):101-105
Scaling of embryonic patterning based on phase-gradient encoding
Lauschke VM; Tsiairis CD; Francois P; Aulehla A
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Alla övriga publikationer

Review: PHARMACOLOGICAL REVIEWS. 2024;76(6):1089-1101
The 75-Year Anniversary of the Department of Physiology and Pharmacology at Karolinska Institutet-Examples of Recent Accomplishments and Future Perspectives
Weitzberg E; Ingelman-Sundberg M; Lundberg JO; Engberg G; Schulte G; Lauschke VM
Editorial comment: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2024;9(1):269
The phage anti-restriction induced system: new insights into bacterial immunity and bacteriophage escape strategies
Zhong Y; Lauschke VM
Review: DRUG METABOLISM AND DISPOSITION. 2024;52(6):467-475
Individualized Pharmacotherapy Utilizing Genetic Biomarkers and Novel In Vitro Systems As Predictive Tools for Optimal Drug Development and Treatment
Ingelman-Sundberg M; Lauschke VM
Editorial comment: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2024;44(5):1098-1100
Hepatic Inhibition of ANGPTL3 Mimics the Molecular Hallmarks of Hypothyroidism
Taebnia N; Lauschke VM
Preprint: BIORXIV. 2024
Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle
Smith JAB; Gabriel B; Abdelmoez A; Savikj M; Wright S; Koutsilieri S; Barrès R; Lauschke V; Krook A; Zierath J; Pillon N
Review: EXPERT REVIEW OF CLINICAL PHARMACOLOGY. 2024;17(3):213-223
Next-generation sequencing in pharmacogenomics - fit for clinical decision support?
Zhou Y; Lauschke VM
Preprint: RESEARCH SQUARE. 2024
SAG1.3-derived Frizzled-targeting negative allosteric modulators
Schulte G; Grätz L; Turku A; Kozielewicz P; Bowin C-F; Scharf M; Voss J; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Körber M; Lauschke V; Löber S; Gmeiner P
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2024;64:33-51
Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward
Lauschke VM; Zhou Y; Ingelman-Sundberg M
Review: GUT MICROBES. 2023;15(1):2158034
In vitro and ex vivo modeling of enteric bacterial infections
Taebnia N; Romling U; Lauschke VM
Conference publication: 2023;:a100.2-a1a101
PA-594 CYP2C8*2 impacts desethylamodiaquine concentration upon repeated artesunate-amodiaquine treatment of uncomplicated malaria in Mali
Camara MD; Tekete M; Dama S; Sousa TND; Kone A; Toure Dinkorma OI; Bamadio A; Djimde M; Dara A; Fofana B; Ogobara D; Lauschke VM; Borrmann S; Djimde AA; Gil JP
Editorial comment: HUMAN GENOMICS. 2023;17(1):105
Emerging trends in pharmacogenomics: from common variant associations toward comprehensive genomic profiling
Ingelman-Sundberg M; Nebert DW; Lauschke VM
Editorial comment: PHARMACOGENOMICS. 2023;24(16):841-844
Towards more accurate pharmacogenomic variant effect predictions
Park Y; M Lauschke V
Preprint: BIORXIV. 2023
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Häggblad M; Ilmain J; Wright S; Murga M; Shlegel J; Sezgin E; Bhabha G; Lauschke V; Lafarga M; Klingström J; Huhn D; Fernandez-Capetillo O
Editorial comment: HEPATOBILIARY SURGERY AND NUTRITION. 2023;12(5):78084-78784
Practice guidance documents for the diagnosis and management of non-alcoholic fatty liver disease-recent updates and open questions
Lauschke VM
Review: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2023
Translating pharmacogenomic sequencing data into drug response predictions-How to interpret variants of unknown significance
Tremmel R; Pirmann S; Zhou Y; Lauschke VM
Preprint: BIORXIV. 2023
Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease
Sommerauer C; Gallardo-Dodd C; Savva C; Hases L; Birgersson M; Indukuri R; Shen J; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke V; Archer A; Williams C; Kutter C
Editorial comment: JOURNAL OF PHYSIOLOGY. 2023;601(8):1317-1318
Rewiring of catecholamine-induced calcium signalling is an early event in non-alcoholic fatty liver disease
Wright SC; Lauschke VM
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S363
Liver spheroids engrafted in the anterior chamber of the eye-a novel platform to study hepatic physiology and pathology
Lazzeri-Barcelo F; Vilarnau N; Leibiger B; Lauschke V; Leibiger I; Berggren P-O; Moruzzi N
Conference publication: 2023
Chemogenomic screening in patient-derived tissue models enables target identification and drug repurposing
Lauschke VM
Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S355
The novel adrenoceptor agonist ATR-127 targets skeletal muscle and brown adipose tissue to counter diabesity and hepatic steatosis
Yakala GK; Talamonti E; Kalinovich A; van Beek SMM; Holliday ND; Suna E; Mutule I; Wright SC; Lauschke VM; Nielsen S; Scheele C; Summers RJ; Hoeks J; Pelcman B; Bengtsson T
Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S503
Longitudinal intraocular imaging of liver spheroids to uncover novel aspects of liver physiology and pathology
Moruzzi N; Lazzeri-Barcelo F; Oliva-Vilarnau N; Baniol M; Leibiger B; Bergmann O; Lauschke VM; Leibiger IB; Berggren P-O
Conference publication: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2023;396:S52
PharmFreq: a comprehensive database of worldwide allelic frequencies in clinically important pharmacogenes
Tremmel R; Zhou Y; Nevosadova L; Laarif S; Eliasson E; Lauschke VM
Conference publication: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2023;396:S52
Assessment of circulating metabolites reveals isobutyrate and propionate associated with lean NAFLD: consequences on steatosis prediction and lipid accumulation
Haag M; Winter S; Kemas AM; Tevini J; Feldman A; Eder S; Felder TK; Datz C; Liebisch G; Burk O; Paulweber B; Lauschke VM; Schwab M; Aigner E
Conference publication: NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY. 2023;396:S52
Multi-dimensional omics profiling of a biobank reveals the interindividual variability of ADME gene expression in human liver
Klein K; Nies AT; Haag M; Hofmann U; Artursson P; Handin N; Burk O; Tremmel R; Winter S; Zhou Y; Schaeffeler E; Zanger UM; Lauschke VM; Schwab M
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2022;10(23):1293-0
Should we test for SLCO1B1 genotype before prescribing statins? A discussion of clinical trial results
Zhou Y; Lauschke VM
Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2022;131(6):452-464
A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing
Zhou Y; Koutsilieri S; Eliasson E; Lauschke VM
Review: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2022;112(6):1159-1171
PharmVar GeneFocus: CYP3A5
Rodriguez-Antona C; Savieo JL; Lauschke VM; Sangkuhl K; Drogemoller BI; Wang D; Schaik RNH; Gilep AA; Peter AP; Boone EC; Ramey BE; Klein TE; Whirl-Carrillo M; Pratt VM; Gaedigk A
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2022;43(10):852-865
Challenges and opportunities associated with rare-variant pharmacogenomics br
Zhou Y; Tremmel R; Schaeffeler E; Schwab M; Lauschke VM
Conference publication: JOURNAL OF HEPATOLOGY. 2022;77:S756-S757
Human resident liver macrophages protect against metabolic stress in obesity
Barreby E; Strunz B; Azzimato V; Shen JX; Naudet L; Sonnerborg I; Sulen A; Nock S; Levi L; Morgantini C; Fardellas A; Johansson H; Nowak G; Stal P; Ellis E; Naslund E; Lauschke V; Bjorkstrom N; Chen P; Aouadi M
Review: HUMAN GENETICS. 2022;141(6):1113-1136
Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health
Zhou Y; Lauschke VM
Letter: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(5):973
Response to Morseburg et al.
Wyckelsma VL; Venckunas T; Houweling PJ; Schlittler M; Lauschke VM; Tiong CF; Wood HD; Paulauskas H; Eimantas N; Andersson DC; North KN; Brazaitis M; Westerblad H
Review: PHARMACOLOGICAL REPORTS. 2022;74(1):47-66
Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts
Dagli-Hernandez C; Zhou Y; Lauschke VM; Genvigir FDV; Hirata TDC; Hirata MH; Hirata RDC
Review: PHARMACOLOGICAL REVIEWS. 2022;74(1):141-206
Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives
Youhanna S; Kemas AM; Preiss L; Zhou Y; Shen JX; Cakal SD; Paqualini FS; Goparaju SK; Shafagh RZ; Lind JU; Sellgren CM; Lauschke VM
Review: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2022;130:5-15
3D human liver spheroids for translational pharmacology and toxicology
Ingelman-Sundberg M; Lauschke VM
Review: ENDOCRINE, METABOLIC AND IMMUNE DISORDERS - DRUG TARGETS. 2022;22(13):1263-1275
Pharmacogenomics of Antihypertensive Drugs in Brazil: Recent Progress and Clinical Implications
Genvigir FDV; Dagli-Hernandez C; Hirata TDC; Zhou Y; Lauschke VM; Hirata MH; Hirata RDC
Book chapter: COMPREHENSIVE PHARMACOLOGY. 2022;p. 53-83
2.05 Computational Methods and Approaches in Pharmacogenomic Research
Zhou Y; Lauschke VM
Preprint: BIORXIV. 2021
Scellseg: a style-aware cell instance segmentation tool with pre-training and contrastive fine-tuning
Xun D; Chen D; Zhou Y; Lauschke V; Wang R; Wang Y
Review: MOLECULAR DIAGNOSIS AND THERAPY. 2021;25(6):735-755
Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients
Crespo Hirata TD; Dagli-Hernandez C; Dalla Vecchia Genvigir F; Lauschke VM; Zhou Y; Hirata MH; Crespo Hirata RD
Review: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2021;110(3):626-636
Computational Tools to Assess the Functional Consequences of Rare and Noncoding Pharmacogenetic Variability
Zhou Y; Lauschke VM
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2021;385(5):463-465
JAK Inhibitors - More Than Just Glucocorticoids
Stebbing J; Lauschke VM
Review: CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2021;110(1):82-97
PharmVar GeneFocus: CYP2B6
Desta Z; El-Boraie A; Gong L; Somogyi AA; Lauschke VM; Dandara C; Klein K; Miller NA; Klein TE; Tyndale RF; Whirl-Carrillo M; Gaedigk A
Review: DRUG METABOLISM REVIEWS. 2021;53(2):253-278
Pharmacogenomics in the era of next generation sequencing - from byte to bedside
Russell LE; Zhou Y; Almousa AA; Sodhi JK; Nwabufo CK; Lauschke VM
Review: DRUG METABOLISM REVIEWS. 2021;53(2):207-233
Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data
Yadav J; El Hassani M; Sodhi J; Lauschke VM; Hartman JH; Russell LE
Review: DRUG METABOLISM REVIEWS. 2021;53(2):245-252
Toxicogenomics of drug induced liver injury - from mechanistic understanding to early prediction.
Lauschke VM
Preprint: BIORXIV. 2021
Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca²⁺ control in skeletal muscle fibers
Gineste C; Youhanna S; Vorrink S; Henriksson S; Hernández A; Cheng A; Chaillou T; Buttgereit A; Schneidereit D; Friedrich O; Hultenby K; Bruton J; Ivarsson N; Sandblad L; Lauschke V; Westerblad H
Corrigendum: NATURE METABOLISM. 2021;3(2):287
Liver macrophages regulate systemic metabolism through non-inflammatory factors (vol 1, pg 445, 2019)
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):8
Systemic IGF-1 treatment affects gene expression in the brain in the preterm rabbit
Hellstrom W; Ekstrom C; Bruschettini M; Carey G; Barton N; Lauschke VM; Vallius-Kvist S; Wang X; Ley D
Editorial comment: FRONTIERS IN GENETICS. 2021;12:736626
Editorial: Population Pharmacogenomics (PGx): From Variant Identification to Clinical Implementation
Hiratsuka M; Zhou Y; Lauschke VM
Review: JOURNAL OF PHARMACEUTICAL SCIENCES. 2021;110(1):50-65
The Past, Present and Future of Intestinal In Vitro Cell Systems for Drug Absorption Studies
Youhanna S; Lauschke VM
Review: PHARMACOGENOMICS. 2020;21(18):1299-1310
The impact of variants in ATP-binding cassette transporters on breast cancer treatment
Xiao Q; Zhou Y; Lauschke VM
Preprint: BIORXIV. 2020
Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation
Wyckelsma VL; Venckunas T; Houweling PJ; Schlittler M; Lauschke VM; Tiong CF; Wood H; Ivarsson N; Paulauskas H; Eimantas N; Andersson DC; North KN; Brazaitis M; Westerblad H
Editorial comment: AMERICAN JOURNAL OF MEDICINE. 2020;133(9):e451-e454
The Network Medicine Imperative and the Need for an International Network Medicine Consortium
Parini P; Altucci L; Balligand J-L; Baumbach J; Ferdinandy P; Filetti S; Maron BA; Petrillo E; Silverman EK; Barabasi A-L; Loscalzo J
Editorial comment: NPJ SYSTEMS BIOLOGY AND APPLICATIONS. 2020;6(1):29
A global network for network medicine
Maron BA; Altucci L; Balligand J-L; Baumbach J; Ferdinandy P; Filetti S; Parini P; Petrillo E; Silverman EK; Barabasi A-L; Loscalzo J
Letter: TRENDS IN PHARMACOLOGICAL SCIENCES. 2020;41(8):503-506
Can CYP Inhibition Overcome Chemotherapy Resistance?
Ingelman-Sundberg M; Lauschke VM
Review: DRUG METABOLISM REVIEWS. 2020;52(3):395-407
Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX)
Russell LE; Schleiff MA; Gonzalez E; Bart AG; Broccatelli F; Hartman JH; Humphreys WG; Lauschke VM; Martin I; Nwabufo C; Prasad B; Scott EE; Segall M; Takahashi R; Taub ME; Sodhi JK
Preprint: RESEARCH SQUARE. 2020
Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients
Stebbing J; Krishnan V; de Bono S; Ottaviani S; Casalini G; Richardson P; Monteil V; Lauschke V; Mirazimi A; Terres JR; Nickoloff B; Higgs R; Rocha G; Byers N; Schlichting D; Cardoso A; Corbellino M
Review: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(1):38-60
Organotypic and Microphysiological Models of Liver, Gut, and Kidney for Studies of Drug Metabolism, Pharmacokinetics, and Toxicity
Shen JX; Youhanna S; Shafagh RZ; Kele J; Lauschke VM
Review: JOURNAL OF CLINICAL MEDICINE. 2020;9(1):E286-286
Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response
Xiao Q; Nobre A; Pineiro P; Berciano-Guerrero M-A; Alba E; Cobo M; Lauschke VM; Barragan I
Review: NPJ GENOMIC MEDICINE. 2020;5(1):9
Emerging strategies to bridge the gap between pharmacogenomic research and its clinical implementation
Lauschke VM; Ingelman-Sundberg M
Letter: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2020;126(1):7-8
One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing"
van der Wouden CH; van Rhenen MH; Jama WOM; Ingelman-Sundberg M; Lauschke VM; Konta L; Schwab M; Swen JJ; Guchelaar H-J
Review: BIOTECHNOLOGY JOURNAL. 2019;14(7):e1800347
3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications
Lauschke VM; Shafagh RZ; Hendriks DFG; Ingelman-Sundberg M
Review: PHARMACOLOGY AND THERAPEUTICS. 2019;197:122-152
Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity
Lauschke VM; Zhou Y; Ingelman-Sundberg M
Corrigendum: NATURE METABOLISM. 2019;1(4):497
Liver macrophages regulate systemic metabolism through non-inflammatory factors (vol 1, 497, 2019)
Morgantini C; Jager J; Li X; Levi L; Azzimato V; Sulen A; Barreby E; Xu C; Tencerova M; Naslund E; Kumar C; Verdeguer F; Straniero S; Hultenby K; Bjorkstrom NK; Ellis E; Ryden M; Kutter C; Hurrell T; Lauschke VM; Boucher J; Tomcala A; Krejcova G; Bajgar A; Aouadi M
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:545-546
Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics
Santos M; Niemi M; Hiratsuka M; Kumondai M; Ingelman-Sundberg M; Lauschke VM; Rodriguez-Antona C
Review: FRONTIERS IN PHARMACOLOGY. 2019;10:1093
Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury
Zhou Y; Shen JX; Lauschke VM
Letter: TOXICOLOGICAL SCIENCES. 2018;165(1):4-5
Current Statistical Metrics Are Pragmatic Measures to Compare the Predictive Quality of Preclinical Assays
Ingelman-Sundberg M; Lauschke VM
Preprint: BIORXIV. 2018
Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions
Reisberg S; Krebs K; Kals M; Mägi R; Metsalu K; Lauschke V; Vilo J; Milani L
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2018;58:161-185
Pharmacoepigenetics and Toxicoepigenetics: Novel Mechanistic Insights and Therapeutic Opportunities
Lauschke VM; Barragan I; Ingelman-Sundberg M
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2018;58:65-82
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery
Ewart L; Dehne E-M; Fabre K; Gibbs S; Hickman J; Hornberg E; Ingelman-Sundberg M; Jang K-J; Jones DR; Lauschke VM; Marx U; Mettetal JT; Pointon A; Williams D; Zimmermann W-H; Newham P
Review: FRONTIERS IN MEDICINE. 2018;5:192
Calcium Signaling in Liver Injury and Regeneration
Oliva-Vilarnau N; Hankeova S; Vorrink SU; Mkrtchian S; Andersson ER; Lauschke VM
Review: FRONTIERS IN PHARMACOLOGY. 2018;9:1437
Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data
Zhou Y; Fujikura K; Mkrtchian S; Lauschke VM
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2018;123:5
AN OPTIMIZED PREDICTION FRAMEWORK TO ASSESS THE FUNCTIONAL IMPACT OF PHARMACOGENETIC VARIANTS
Zhou Y; Mkrtchian S; Kumondai M; Hiratsuka M; Lauschke V
Conference publication: BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. 2018;123:89
NOVEL COPY NUMBER VARIANTS IN PHARMACOGENES CONTRIBUTE TO INTERINDIVIDUAL DIFFERENCES IN DRUG PHARMACOKINETICS
Santos M; Niemi M; Hiratsuka M; Kumondai M; Ingelman-Sundberg M; Lauschke VM; Rodriguez-Antona C
Review: AAPS JOURNAL. 2017;20(1):4
Plharmacogenomic Biomarkers for Improved Drug Therapy- Recent Progress and Future Developments
Lauschke VM; Milani L; Ingelman-Sundberg M
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2017;38(9):765-770
Pitfalls and Opportunities for Epigenomic Analyses Focused on Disease Diagnosis, Prognosis, and Therapy
Lauschke VM; Ivanov M; Ingelman-Sundberg M
Editorial comment: CLINICAL SCIENCE. 2017;131(15):2059-2062
Dysregulation of miR-223 constitutes a promising biomarker that informs about clinical outcomes of acute liver failure
Lauschke VM
Review: CHEMICAL RESEARCH IN TOXICOLOGY. 2016;29(12):1936-1955
Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates
Lauschke VM; Hendriks DFG; Bell CC; Andersson TB; Ingelman-Sundberg M
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(10):E1714-1714
The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity
Lauschke VM; Ingelman-Sundberg M
Editorial comment: TRENDS IN PHARMACOLOGICAL SCIENCES. 2016;37(2):85-86
Precision Medicine and Rare Genetic Variants
Lauschke VM; Ingelman-Sundberg M
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Forskningsbidrag

Targeting tissue crosstalk to combat non-alcoholic fatty liver disease
Swedish Research Council
1 January 2024 - 31 December 2028
Chemogenomic profiling of nuclear hormone receptors as targets for NASH
Novo Nordisk Foundation
1 November 2023 - 31 October 2025
Tissue units constructed by extracellular matrix mimics based on bioengineered silk
Swedish Research Council
1 January 2023 - 31 December 2026
A chemogenomic approach to target identification in primary human NASH models
Deutsche Forschungsgemeinschaft
1 January 2023
Targeting adipose tissue-liver cross talk to combat non-alcoholic fatty liver disease
Swedish Research Council
1 January 2022 - 31 December 2025
Human 3D liver spheroids as a microphysiological platform for the development of drugs against liver diseases
Swedish Research Council
1 December 2019 - 31 December 2022
Treatment of liver failure by generation of fully functional human hepatocytes via a proliferative intermediate
Swedish Research Council
1 January 2017 - 31 December 2020
Functional human 3D in vitro models as new experimental paradigm for understanding drug-induced hepatotoxicity and liver disease
Swedish Research Council
1 January 2017 - 31 December 2019
Novel hepatic in vitro models for use in drug development
Swedish Research Council
1 January 2016 - 31 December 2016

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