Ulf Eriksson
Professor, Senior
E-postadress: ulf.pe.eriksson@ki.se
Telefon: +46852487109
Besöksadress: Solnavägen 9, 6D, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Vaskulärbiologi Eriksson, 171 77 Stockholm
Del av:
- Institutionen för medicinsk biokemi och biofysik
- Ulf Erikssons grupp
Om mig
- Ulf Eriksson är professor i vaskulär biokemi med särskild inriktning mot
tillväxtfaktorreglerade endotelcellsfunktioner vid institutionen för
medicinsk biokemi och biofysik.
Artiklar
- Article: KIDNEY INTERNATIONAL. 2025;107(3):492-507Folestad E; Mehlem A; Ning FC; Oosterveld T; Palombo I; Singh J; Olauson H; Witasp A; Thorell A; Stenvinkel P; Ebefors K; Nystrom J; Eriksson U; Falkevall A
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;135(5):e171077Protzmann J; Zeitelhofer M; Stefanitsch C; Torrente D; Adzemovic MZ; Matjunins K; Randel SJI; Lewandowski SA; Muhl L; Eriksson U; Nilsson I; Su EJ; Lawrence DA; Fredriksson L
- Journal article: BIORXIV. 2024;:2024.10.11.617532Nilsson I; Su EJ; Fredriksson L; Sahlgren BH; Bagoly Z; Moessinger C; Stefanitsch C; Ning FC; Zeitelhofer M; Muhl L; Lawrence A-LE; Scotney PD; Lu L; Samén E; Ho H; Keep RF; Medcalf RL; Lawrence DA; Eriksson U
- Article: CANCERS. 2024;16(10):1902Janes PW; Parslow AC; Cao D; Rigopoulos A; Lee F-T; Gong SJ; Cartwright GA; Burvenich IJG; Eriksson U; Johns TG; Scott FE; Scott AM
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2024;194(5):641-655Firat EAM; Buhl EM; Bouteldja N; Smeets B; Eriksson U; Boor P; Klinkhammer BM
- Article: JOURNAL OF HEPATOLOGY. 2023;78(5):901-913Falkevall A; Mehlem A; Folestad E; Ning FC; Osorio-Conles O; Radmann R; de Hollanda A; Wright SD; Scotney P; Nash A; Eriksson U
- Article: BLOOD. 2022;140(4):388-400Goncalves A; Su EJ; Muthusamy A; Zeitelhofer M; Torrente D; Nilsson I; Protzmann J; Fredriksson L; Eriksson U; Antonetti DA; Lawrence DA
- Article: SCIENTIFIC REPORTS. 2020;10(1):22383Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
- Article: LUNG CANCER. 2020;150:1-8Chia PL; Russell P; Asadi K; Thapa B; Gebski V; Murone C; Walkiewicz M; Eriksson U; Scott AM; John T
- Article: EMBO REPORTS. 2020;21(7):e49343VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol contentMoessinger C; Nilsson I; Muhl L; Zeitelhofer M; Heller Sahlgren B; Skogsberg J; Eriksson U
- Article: SCIENTIFIC REPORTS. 2020;10(1):923Ning FC; Jensen N; Mi J; Lindstrom W; Balan M; Muhl L; Eriksson U; Nilsson I; Nyqvist D
- Article: SCIENTIFIC REPORTS. 2019;9(1):14636Balan M; Trusohamn M; Ning FC; Jacob S; Pietras K; Eriksson U; Berggren P-O; Nyqvist D
- Article: KIDNEY INTERNATIONAL. 2019;95(5):1103-1119van Roeyen CRC; Martin IV; Drescher A; Schuett KA; Hermert D; Raffetseder U; Otten S; Buhl EM; Braun GS; Kuppe C; Liehn E; Boor P; Weiskirchen R; Eriksson U; Gross O; Eitner F; Floege J; Ostendorf T
- Article: PLOS ONE. 2018;13(7):e0201089Li H; Zeitelhofer M; Nilsson I; Liu X; Allan L; Gloria B; Perani A; Murone C; Catimel B; Neville AM; Scott FE; Scott AM; Eriksson U
- Article: PLOS ONE. 2018;13(7):e0200649Zeitelhofer M; Li H; Adzemovic MZ; Nilsson I; Muhl L; Scott AM; Eriksson U
- Article: NEURORADIOLOGY. 2018;60(7):759-768Jaff N; Grankvist R; Muhl L; Chireh A; Sandell M; Jonsson S; Arnberg F; Eriksson U; Holmin S
- Article: NATURE MEDICINE. 2018;24(4):463-473Roswall P; Bocci M; Bartoschek M; Li H; Kristiansen G; Jansson S; Lehn S; Sjolund J; Reid S; Larsson C; Eriksson P; Anderberg C; Cortez E; Saal LH; Orsmark-Pietras C; Cordero E; Haller BK; Hakkinen J; Burvenich IJG; Lim E; Orimo A; Hoglund M; Ryden L; Moch H; Scott AM; Eriksson U; Pietras K
- Article: ACTA NEUROPATHOLOGICA. 2017;134(4):585-604Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic strokeSu EJ; Cao C; Fredriksson L; Nilsson I; Stefanitsch C; Stevenson TK; Zhao J; Ragsdale M; Sun Y-Y; Yepes M; Kuan C-Y; Eriksson U; Strickland DK; Lawrence DA; Zhang L
- Article: JOURNAL OF CELL SCIENCE. 2017;130(8):1365-1378Muhl L; Folestad EB; Gladh H; Wang Y; Moessinger C; Jakobsson L; Eriksson U
- Article: CELL METABOLISM. 2017;25(3):713-726Falkevall A; Mehlem A; Palombo I; Sahlgren BH; Ebarasi L; He L; Ytterberg AJ; Olauson H; Axelsson J; Sundelin B; Patrakka J; Scotney P; Nash A; Eriksson U
- Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(3):273-283Wahlgren N; Thoren M; Hojeberg B; Kall T-B; Laska A-C; Sjostrand C; Hoijer J; Almqvist H; Holmin S; Lilja A; Fredriksson L; Lawrence D; Eriksson U; Ahmed N
- Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Yla-Herttuala S; Eriksson U
- Article: BIOLOGY OPEN. 2016;5(4):461-474Andrae J; Gouveia L; Gallini R; He L; Fredriksson L; Nilsson I; Johansson BR; Eriksson U; Betsholtz C
- Article: KIDNEY INTERNATIONAL. 2016;89(4):848-861Buhl EM; Djudjaj S; Babickova J; Klinkhammer BM; Folestad E; Borkham-Kamphorst E; Weiskirchen R; Hudkins K; Alpers CE; Eriksson U; Floege J; Boor P
- Article: DIABETES. 2016;65(4):861-873Mehlem A; Palombo I; Wang X; Hagberg CE; Eriksson U; Falkevall A
- Article: PLOS ONE. 2016;11(3):e0152276Gladh H; Folestad EB; Muhl L; Ehnman M; Tannenberg P; Lawrence A-L; Betsholtz C; Eriksson U
- Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464Lewandowski SA; Nilsson I; Fredriksson L; Lonnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(7):E864-E873Cortez E; Gladh H; Braun S; Bocci M; Cordero E; Bjorkstrom NK; Miyazaki H; Michael IP; Eriksson U; Folestad E; Pietras K
- Article: JOURNAL OF NEUROTRAUMA. 2015;32(21):1645-1657Kjell J; Finn A; Hao J; Wellfelt K; Josephson A; Svensson CI; Wiesenfeld-Hallin Z; Eriksson U; Abrams M; Olson L
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2015;9:385Su EJ; Fredriksson L; Kanzawa M; Moore S; Folestad E; Stevenson TK; Nilsson I; Sashindranath M; Schielke GP; Warnock M; Ragsdale M; Mann K; Lawrence A-LE; Medcalf RL; Eriksson U; Murphy GG; Lawrence DA
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2015;185(8):2132-2142Boor P; Babickova J; Steegh F; Hautvast P; Martin IV; Djudjaj S; Nakagawa T; Ehling J; Gremse F; Buecher E; Eriksson U; van Roeyen CRC; Eitner F; Lammers T; Floege J; Peutz-Kootstra CJ; Ostendorf T
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2015;308(7):L658-L671Johnson JR; Folestad E; Rowley JE; Noll EM; Walker SA; Lloyd CM; Rankin SM; Pietras K; Eriksson U; Fuxe J
- Article: STROKE. 2014;45(6):1657-1663Mazya MV; Ahmed N; Ford GA; Hobohm C; Mikulik R; Nunes AP; Wahlgren N
- Article: CARDIOVASCULAR RESEARCH. 2013;99(4):716-723Heinonen SE; Kivela AM; Huusko J; Dijkstra MH; Gurzeler E; Makinen PI; Leppanen P; Olkkonen VM; Eriksson U; Jauhiainen M; Yla-Herttuala S
- Journal article: EUROPEAN HEART JOURNAL. 2013;34(suppl_1):p2386Kivela A; Heinonen SE; Leppanen P; Dijkstra MH; Gurzeler E; Huusko J; Olkkonen VM; Eriksson U; Jauhiainen M; Yla-Herttuala S
- Journal article: PLOS ONE. 2013;8(6):10.1371/annotation/dd60f2Z. Adzemovic M; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
- Article: NATURE PROTOCOLS. 2013;8(6):1149-1154Mehlem A; Hagberg CE; Muhl L; Eriksson U; Falkevall A
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2013;28(4):889-900Seikrit C; Henkel C; van Roeyen CRC; Bokemeyer D; Eitner F; Martin IV; Boor P; Knuechel R; Meyer HE; Mueller-Newen G; Eriksson U; Floege J; Ostendorf T
- Article: CANCER RESEARCH. 2013;73(7):2139-2149Ehnman M; Missiaglia E; Folestad E; Selfe J; Strell C; Thway K; Brodin B; Pietras K; Shipley J; Ostman A; Eriksson U
- Article: PLOS ONE. 2013;8(2):e56586Adzemovic MZ; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(1):107-117Martin IV; Borkham-Kamphorst E; Zok S; van Roeyen CRC; Eriksson U; Boor P; Hittatiya K; Fischer H-P; Wasmuth HE; Weiskirchen R; Eitner F; Floege J; Ostendorf T
- Article: NATURE. 2012;490(7420):426-430Hagberg CE; Mehlem A; Falkevall A; Muhl L; Fam BC; Ortsater H; Scotney P; Nyqvist D; Samen E; Lu L; Stone-Elander S; Proietto J; Andrikopoulos S; Sjoholm A; Nash A; Eriksson U
- Journal article: ANNALS OF ONCOLOGY. 2012;23:xi39Li H; Kristiansen G; Holger M; Eriksson U
- Article: PLOS ONE. 2012;7(6):e38760Abrams MB; Nilsson I; Lewandowski SA; Kjell J; Codeluppi S; Olson L; Eriksson U
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(3):1136-1144Fredriksson L; Nilsson I; Su EJ; Andrae J; Ding H; Betsholtz C; Eriksson U; Lawrence DA
- Article: PLOS ONE. 2010;5(11):e14109Albrecht I; Kopfstein L; Strittmatter K; Schomber T; Falkevall A; Hagberg CE; Lorentz P; Jeltsch M; Alitalo K; Eriksson U; Christofori G; Pietras K
- Article: JOURNAL OF NEUROSCIENCE. 2010;30(45):15052-15066Ruiz de Almodovar C; Coulon C; Salin PA; Knevels E; Chounlamountri N; Poesen K; Hermans K; Lambrechts D; Van Geyte K; Dhondt J; Dresselaers T; Renaud J; Aragones J; Zacchigna S; Geudens I; Gall D; Stroobants S; Mutin M; Dassonville K; Storkebaum E; Jordan BF; Eriksson U; Moons L; D'Hooge R; Haigh JJ; Belin M-F; Schiffmann S; Van Hecke P; Gallez B; Vinckier S; Chédotal A; Honnorat J; Thomasset N; Carmeliet P; Meissirel C
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):58-69Boor P; van Roeyen CRC; Kunter U; Villa L; Bücher E; Hohenstein B; Hugo CPM; Eriksson U; Satchell SC; Mathieson PW; Eitner F; Floege J; Ostendorf T
- Article: NATURE. 2010;464(7290):917-921Hagberg CE; Falkevall A; Wang X; Larsson E; Huusko J; Nilsson I; van Meeteren LA; Samen E; Lu L; Vanwildemeersch M; Klar J; Genove G; Pietras K; Stone-Elander S; Claesson-Welsh L; Yla-Herttuala S; Lindahl P; Eriksson U
- Article: CARDIOVASCULAR RESEARCH. 2010;86(1):122-130Huusko J; Merentie M; Dijkstra MH; Ryhanen M-M; Karvinen H; Rissanen TT; Vanwildemeersch M; Hedman M; Lipponen J; Heinonen SE; Eriksson U; Shibuya M; Yla-Herttuala S
- Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2009;39(4):320-327Karvinen H; Rutanen J; LeppAnen O; Lach R; Levonen A-L; Eriksson U; Ylae-Herttuala S
- Article: CIRCULATION. 2009;119(6):845-856Laehteenvuo JE; Laehteenvuo MT; Kivelae A; Rosenlew C; Falkevall A; Klar J; Heikura T; Rissanen TT; Vaehaekangas E; Korpisalo P; Enholm B; Carmeliet P; Alitalo K; Eriksson U; Ylae-Herttuala S
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2009;296(2):H442-H452Thomas JA; Deaton RA; Hastings NE; Shang Y; Moehle CW; Eriksson U; Topouzis S; Wamhoff BR; Blackman BR; Owens GK
- Article: ONCOGENE. 2009;28(4):534-544Ehnman M; Li H; Fredriksson L; Pietras K; Eriksson U
- Article: CANCER RESEARCH. 2009;69(1):369-378Anderberg C; Li H; Fredriksson L; Andrae J; Betsholtz C; Li X; Eriksson U; Pietras K
- Article: CIRCULATION RESEARCH. 2008;103(10):1092-U71Korpisalo P; Karvinen H; Rissanen TT; Kilpijoki J; Marjomaki V; Baluk P; McDonald DM; Cao Y; Eriksson U; Alitalo K; Yla-Herttuala S
- Article: JOURNAL OF NEUROSCIENCE. 2008;28(42):10451-10459Poesen K; Lambrechts D; Van Damme P; Dhondt J; Bender F; Frank N; Bogaert E; Claes B; Heylen L; Verheyen A; Raes K; Tjwa M; Eriksson U; Shibuya M; Nuydens R; Van Den Bosch L; Meert T; D'Hooge R; Sendtner M; Robberecht W; Carmeliet P
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008;28(9):1614-1620Li X; Tjwa M; Van Hove I; Enholm B; Neven E; Paavonen K; Jeltsch M; Juan TD; Sievers RE; Chorianopoulos E; Wada H; Vanwildemeersch M; Noel A; Foidart J-M; Springer ML; von Degenfeld G; Dewerchin M; Blau HM; Alitalo K; Eriksson U; Carmeliet P; Moons L
- Article: NATURE MEDICINE. 2008;14(7):731-737Su EJ; Fredriksson L; Geyer M; Folestad E; Cale J; Andrae J; Gao Y; Pietras K; Mann K; Yepes M; Strickland DK; Betsholtz C; Eriksson U; Lawrence DA
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):281-289Eitner F; Buecher E; van Roeyen C; Kunter U; Rong S; Seikrit C; Villa L; Boor P; Fredriksson L; Bakstrom G; Eriksson U; Ostman A; Floege J; Ostendorf T
- Article: FASEB JOURNAL. 2007;21(13):3696-3704Ost A; Danielsson A; Lidén M; Eriksson U; Nystrom FH; Strålfors P
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(11):3188-3197Tirziu D; Chorianopoulos E; Moodie KL; Palac RT; Zhuang ZW; Tjwa M; Roncal C; Eriksson U; Fu Q; Elfenbein A; Hall AE; Carmeliet P; Moons L; Simons M
- Journal article: CIRCULATION. 2007;116(suppl_16)Markkanen JE; Nurminen MT; Kivelä A; Heikura T; Eriksson U; Ylä-Herttuala S
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2006;63(10):1205-1213Shafqat N; Shafqat J; Eissner G; Marschall HU; Tryggvason K; Eriksson U; Gabrielli F; Lardy H; Jörnvall H; Oppermann U
- Article: EXPERIMENTAL CELL RESEARCH. 2005;311(2):205-217Lidén M; Tryggvason K; Eriksson U
- Article: CIRCULATION RESEARCH. 2005;97(10):1036-1045Pontén A; Folestad EB; Pietras K; Eriksson U
- Article: EXPERIMENTAL CELL RESEARCH. 2005;310(2):401-408Lidén M; Eriksson U
- Article: CIRCULATION. 2005;112(9):1347-1352Leppänen P; Koota S; Kholová I; Koponen J; Fieber C; Eriksson U; Alitalo K; Ylä-Herttuala S
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):26856-26862Fredriksson L; Ehnman M; Fieber C; Eriksson U
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2005;115(1):118-127Li XR; Tjwa M; Moons L; Fons P; Noel A; Ny A; Zhou JM; Lennartsson J; Li H; Luttun A; Pontén A; Devy L; Bouché A; Oh H; Manderveld A; Blacher S; Communi D; Savi P; Bono F; Dewerchin M; Foidart JM; Autiero M; Herbert JM; Collen D; Heldin CH; Eriksson U; Carmeliet P
- Article: BLOOD. 2004;104(10):3198-3204Uutela M; Wirzenius M; Paavonen K; Rajantie I; He YL; Karpanen T; Lohela M; Wiig H; Salven P; Pajusola K; Eriksson U; Alitalo K
- Article: EMBO JOURNAL. 2004;23(19):3793-3802Fredriksson L; Li H; Fieber C; Li X; Eriksson U
- Article: CANCER RESEARCH. 2004;64(8):2725-2733Furuhashi M; Sjöblom T; Abramsson A; Ellingsen J; Micke P; Li H; Bergsten-Folestad E; Eriksson U; Heuchel R; Betsholtz C; Heldin CH; Östman A
- Journal article: FERTILITY AND STERILITY. 2003;80 Suppl 2:803-811Molinas CR; Campo R; Dewerchin M; Eriksson U; Carmeliet P; Koninckx PR
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(2):673-682Pontén A; Li XR; Thorén P; Aase K; Sjöblom T; Östman A; Eriksson U
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(5):1145-1153Eitner F; Ostendorf T; Kretzler M; Cohen CD; Eriksson U; Gröne H-J; Floege J; ERCB-Consortium
- Article: EXPERIMENTAL CELL RESEARCH. 2003;285(2):286-298Tille J-C; Wang X; Lipson KE; McMahon G; Ferrara N; Zhu Z; Hicklin DJ; Sleeman JP; Eriksson U; Alitalo K; Pepper MS
- Article: ONCOGENE. 2003;22(10):1501-1510Li H; Fredriksson L; Li X; Eriksson U
- Article: FASEB JOURNAL. 2002;16(12):1575-1583Cao RH; Bråkenhielm E; Li XR; Pietras K; Widenfalk J; Östman A; Eriksson U; Cao YH
- Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2002;13(4):910-917Eitner F; Ostendorf T; Van Roeyen C; Kitahara M; Li X; Aase K; Gröne H-J; Eriksson U; Floege J
- Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2002;398(2):284-290Heldin CH; Eriksson U; Östman A
- Article: MECHANISMS OF DEVELOPMENT. 2002;110(1-2):187-191Aase K; Abramsson A; Karlsson L; Betsholtz C; Eriksson U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(52):49251-49257Lidén M; Romert A; Tryggvason K; Persson B; Eriksson U
- Article: MECHANISMS OF DEVELOPMENT. 2001;109(1):69-77Heino TI; Kärpänen T; Wahlström G; Pulkkinen M; Eriksson U; Alitalo K; Roos C
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;286(2):336-342Gidlöf AC; Romert A; Olsson A; Törmä H; Eriksson U; Sirsjö A
- Article: CIRCULATION. 2001;104(3):358-364Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(22):19253-19258Tryggvason K; Romert A; Eriksson U
- Article: CIRCULATION. 2001;103(18):2242-2247Uutela M; Laurén J; Bergsten E; Li XR; Horelli-Kuitunen N; Eriksson U; Alitalo K
- Article: FASEB JOURNAL. 2001;15(7):1221-1223Wuttge DM; Romert A; Eriksson U; Törmä H; Hansson GK; Sirsjö A
- Article: NATURE CELL BIOLOGY. 2001;3(5):512-516Bergsten E; Uutela M; Li X; Pietras K; Ostman A; Heldin CH; Alitalo K; Eriksson U
- Article: NATURE MEDICINE. 2001;7(5):575-583Carmeliet P; Moons L; Luttun A; Vincenti V; Compernolle V; De Mol M; Wu Y; Bono F; Devy L; Beck H; Scholz D; Acker T; DiPalma T; Dewerchin M; Noel A; Stalmans I; Barra A; Blacher S; VandenDriessche T; Ponten A; Eriksson U; Plate KH; Foidart JM; Schaper W; Charnock-Jones DS; Hicklin DJ; Herbert JM; Collen D; Persico MG
- Article: JOURNAL OF CELL BIOLOGY. 2001;153(3):543-553Hellström M; Gerhardt H; Kalén M; Li XR; Eriksson U; Wolburg H; Betsholtz C
- Article: GROWTH FACTORS. 2001;19(1):49-59Li X; Aase K; Li H; von Euler G; Eriksson U
- Journal article: ATHEROSCLEROSIS. 2000;151(1):198Wuttge DM; Romert A; Hansson GK; Eriksson U; Sirsjö A
- Article: NATURE CELL BIOLOGY. 2000;2(5):302-309Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin CH; Alitalo K; Ostman A; Eriksson U
- Article: EXPERIMENTAL CELL RESEARCH. 2000;256(1):338-345Romert A; Tuvendal P; Tryggvason K; Dencker L; Eriksson U
- Article: CIRCULATION RESEARCH. 1999;85(11):992-999Lymboussaki A; Olofsson B; Eriksson U; Alitalo K
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(30):21217-21222Makinen T; Olofsson B; Karpanen T; Hellman U; Soker S; Klagsbrun M; Eriksson U; Alitalo K
- Article: PLACENTA. 1999;20(5-6):459-465Johansson S; Gustafson AL; Donovan M; Eriksson U; Dencker L
- Article: NATURE GENETICS. 1999;22(2):188-191Yamamoto H; Simon A; Eriksson U; Harris E; Berson EL; Dryja TP
- Article: DEVELOPMENTAL DYNAMICS. 1999;215(1):12-25Aase K; Lymboussaki A; Kaipainen A; Olofsson B; Alitalo K; Eriksson U
- Article: DEVELOPMENTAL BRAIN RESEARCH. 1999;114(1):121-126Gustafson AL; Eriksson U; Dencker L
- Article: BIOCHEMICAL JOURNAL. 1999;338 ( Pt 1)(Pt 1):23-27Wang J; Chai X; Eriksson U; Napoli JL
- Article: JOURNAL OF CELL SCIENCE. 1999;112(4):549-558Simon A; Romert A; Gustafson AL; McCaffery JM; Eriksson U
- Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(2):407-416Zetterström RH; Lindqvist E; de Urquiza AM; Tomac A; Eriksson U; Perlmann T; Olson L
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(20):11709-11714Olofsson B; Korpelainen E; Pepper MS; Mandriota SJ; Aase K; Kumar V; Gunji Y; Jeltsch MM; Shibuya M; Alitalo K; Eriksson U
- Article: AMERICAN JOURNAL OF PATHOLOGY. 1998;153(1):103-108Salven P; Lymboussaki A; Heikkilä P; Jääskela-Saari H; Enholm B; Aase K; von Euler G; Eriksson U; Alitalo K; Joensuu H
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(8):4404-4409Romert A; Tuvendal P; Simon A; Dencker L; Eriksson U
- Article: PROGRESS IN RETINAL AND EYE RESEARCH. 1997;16(3):375-399Eriksson U
- Article: BRAIN STRUCTURE & FUNCTION. 1997;195(6):483-490Johansson S; Gustafson AL; Donovan M; Romert A; Eriksson U; Dencker L
- Article: ONCOGENE. 1997;14(20):2475-2483Enholm B; Paavonen K; Ristimäki A; Kumar V; Gunji Y; Klefstrom J; Kivinen L; Laiho M; Olofsson B; Joukov V; Eriksson U; Alitalo K
- Article: AUDITORY NEUROSCIENCE. 1997;3(4):415Ylikoski J; Pirvola U; Zhai SQ; Eriksson U; Solin ML; Miettinen A
- Article: GENOMICS. 1996;36(3):424-430Simon A; Lagercrantz J; BajalicaLagercrantz S; Eriksson U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(32):19310-19317Olofsson B; Pajusola K; von Euler G; Chilov D; Alitalo K; Eriksson U
- Article: MECHANISMS OF DEVELOPMENT. 1996;58(1-2):27-38Gustafson AL; Donovan M; Annerwall E; Dencker L; Eriksson U
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(6):2576-2581Olofsson B; Pajusola K; Kaipainen A; von Euler G; Joukov V; Saksela O; Orpana A; Pettersson RF; Alitalo K; Eriksson U
- Article: CIRCULATION. 1996;93(6):1079-1082Paavonen K; Horelli-Kuitunen N; Chilov D; Kukk E; Pennanen S; Kallioniemi OP; Pajusola K; Olofsson B; Eriksson U; Joukov V; Palotie A; Alitalo K
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1995;210(1):105-112Melhus H; Båvik CO; Rask L; Peterson PA; Eriksson U
- Article: DEVELOPMENT. 1995;121(3):825-837Lee YM; Osumi-Yamashita N; Ninomiya Y; Moon CK; Eriksson U; Eto K
- Article: EXPERIMENTAL CELL RESEARCH. 1995;216(2):358-362Båvik CO; Peterson A; Eriksson U
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(3):1107-1112SIMON A; HELLMAN U; WERNSTEDT C; ERIKSSON U
- Journal article: JOURNAL OF COMPARATIVE NEUROLOGY. 1994;349(4):596-602Ylikoski J; Pirvola U; Eriksson U
- Journal article: NEUROSCIENCE. 1994;62(3):899-918ZETTERSTROM RH; SIMON A; GIACOBINI MMJ; ERIKSSON U; OLSON L
- Journal article: ARCHIVES OF ORAL BIOLOGY. 1993;38(10):837-843Berkovitz BK; Maden M; Eriksson U
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1993;268(27):20540-20546Båvik CO; Lévy F; Hellman U; Wernstedt C; Eriksson U
- Journal article: BIOESSAYS. 1993;15(6):434-435Eriksson U
- Journal article: DEVELOPMENT. 1993;117(2):451-460Gustafson AL; Dencker L; Eriksson U
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1992;99(6):795-802Busch C; Siegenthaler G; Vahlquist A; Nordlinder H; Sundelin J; Saksena P; Eriksson U
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1992;267(32):23035-23042Båvik CO; Busch C; Eriksson U
- Journal article: BIOCHEMICAL JOURNAL. 1992;287(Pt 2):383-389SIEGENTHALER G; TOMATIS I; CHATELLARDGRUAZ D; JACONI S; ERIKSSON U; SAURAT JH
- Journal article: MECHANISMS OF DEVELOPMENT. 1992;37(1-2):13-23Maden M; Horton C; Graham A; Leonard L; Pizzey J; Siegenthaler G; Lumsden A; Eriksson U
- Journal article: ORTHODONTICS & CRANIOFACIAL RESEARCH. 1991;11(4):303-314Dencker L; Gustafson AL; Annerwall E; Busch C; Eriksson U
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1991;266(23):14978-14985Båvik CO; Eriksson U; Allen RA; Peterson PA
- Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(9):3666-3670Hunter K; Maden M; Summerbell D; Eriksson U; Holder N
- Journal article: DEVELOPMENT. 1991;111(1):35-43Maden M; Hunt P; Eriksson U; Kuroiwa A; Krumlauf R; Summerbell D
- Journal article: DEVELOPMENT. 1990;110(2):343-352Dencker L; Annerwall E; Busch C; Eriksson U
- Journal article: HEPATOLOGY. 1988;8(1):136-141Nyberg A; Berne B; Nordlinder H; Busch C; Eriksson U; Lööf L; Vahlquist A
- Journal article: JOURNAL OF CELLULAR PHYSIOLOGY. 1987;133(3):482-490Eriksson U; Hansson E; Nordlinder H; Busch C; Sundelin J; Peterson PA
- Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1987;148(3):1425-1431Böhmer FD; Sun Q; Pepperle M; Müller T; Eriksson U; Wang JL; Grosse R
- Journal article: CANCER RESEARCH. 1986;46(2):717-722Eriksson U; Hansson E; Nilsson M; Jönsson KH; Sundelin J; Peterson PA
- Journal article: CHEMISTRY AND PHYSICS OF LIPIDS. 1985;38(1-2):175-185Sundelin J; Eriksson U; Melhus H; Nilsson M; Lundvall J; Båvik CO; Hansson E; Laurent B; Peterson PA
- Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1985;130(1):431-439Colantuoni V; Cortese R; Nilsson M; Lundvall J; Båvik CO; Eriksson U; Peterson PA; Sundelin J
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1985;260(10):6488-6493Sundelin J; Anundi H; Trägårdh L; Eriksson U; Lind P; Ronne H; Peterson PA; Rask L
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1985;260(10):6481-6487Sundelin J; Melhus H; Das S; Eriksson U; Lind P; Trägårdh L; Peterson PA; Rask L
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1985;260(10):6472-6480Sundelin J; Laurent BC; Anundi H; Trägårdh L; Larhammar D; Björck L; Eriksson U; Akerström B; Jones A; Newcomer M
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1985;260(10):6494-6499Sundelin J; Das SR; Eriksson U; Rask L; Peterson PA
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1984;259(21):13464-13470Eriksson U; Das K; Busch C; Nordlinder H; Rask L; Sundelin J; Sällström J; Peterson PA
- Journal article: EMBO JOURNAL. 1984;3(7):1451-1454Newcomer ME; Jones TA; Aqvist J; Sundelin J; Eriksson U; Rask L; Peterson PA
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1983;81(1 Suppl):s59-s63Sundelin J; Busch C; Das K; Das S; Eriksson U; Jönsson KH; Kämpe O; Laurent B; Liljas A; Newcomer M; Nilsson M; Norlinder H; Rask L; Ronne H; Peterson PA
- Journal article: EXPERIMENTAL CELL RESEARCH. 1983;143(1):91-102Rask L; Valtersson C; Anundi H; Kvist S; Eriksson U; Dallner G; Peterson PA
- Journal article: FEBS LETTERS. 1981;135(1):70-72Eriksson U; Sundelin J; Rask L; Peterson PA
- Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1981;256(15):8162-8163Newcomer ME; Liljas A; Eriksson U; Sundelin J; Rask L; Peterson PA
- Journal article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1981;359:79-90Rask L; Anundi H; Böhme J; Eriksson U; Ronne H; Sege K; Peterson PA
- Journal article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION, SUPPLEMENT. 1980;154:45-61Rask L; Anundi H; Böhme J; Eriksson U; Fredriksson A; Nilsson SF; Ronne H; Vahlquist A; Peterson PA
- Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1980;11(1):63-72Kvist S; Eriksson U; Peterson PA
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Alla övriga publikationer
- Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S78Falkevall A; Mehlem A; Folestad E; Zeitelhofer M; Scotney P; Eriksson U
- Preprint: BIORXIV. 2021Zeitelhofer M; Stefanitsch C; Protzmann J; Torrente D; Adzemovic MZ; Lewandowski SA; Muhl L; Eriksson U; Nilsson I; Su EJ; Lawrence DA; Fredriksson L
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:930Zeitelhofer M; Adzemovic MZ; Huang J; Stefanitsch C; Mossinger C; Hochmeister S; Strell C; Muhl L; Lassmann H; Kockum I; Fredriksson L; Olsson T; Nilsson I; Eriksson U
- Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2018;13(10):S399Chia PL; Russell P; Asadi K; Murone C; Walkiewicz M; Eriksson U; Scott A; John T
- Conference publication: CANCER RESEARCH. 2018;78(13):1557Chia PL; Russell P; Murone C; Walkiewicz M; Eriksson U; Scott A; John T
- Editorial comment: CELL METABOLISM. 2018;27(6):1161-1162Eriksson U; Falkevall A
- Conference publication: BRAIN INJURY. 2017;31(6-7):917Su J; Chou C; Eriksson U; Medcalf R; Murphy G; Stern S; Lawrence D
- Review: PHARMACOLOGY & THERAPEUTICS. 2016;167:108-119Lewandowski SA; Fredriksson L; Lawrence DA; Eriksson U
- Review: EUROPEAN JOURNAL OF HEART FAILURE. 2015;17(11):1091-1103Bang C; Antoniades C; Antonopoulos AS; Eriksson U; Franssen C; Hamdani N; Lehmann L; Moessinger C; Mongillo M; Muhl L; Speer T; Thum T
- Corrigendum: PLOS ONE. 2015;10(4):e0123142Adzemovic ZM; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
- Meeting abstract: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):32Adzemovic MZ; Zeitelhofer M; Eriksson U; Olsson T; Nilsson I
- Editorial comment: EXPERIMENTAL NEUROLOGY. 2014;257:182-185Abrams MB; Nilsson I; Kjell J; Lewandowski S; Codeluppi S; Eriksson U; Olson L
- Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2014;29:452Boor P; Babickova J; Martin IV; Buecher EB; Eriksson U; Van Roeyen CRC; Eitner F; Floege J; Peutz-Kootstra CJ; Ostendorf T
- Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2014;29:61Van Roeyen CRC; Drescher A; Hess K; Boor P; Martin IV; Zok S; Braun G; Kuppe C; Liehn E; Weiskirchen R; Eriksson U; Gross O; Floege J; Eitner F; Ostendorf T
- Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2014;29:45Buhl EM; Djudjaj S; Klinkhammer BM; Eriksson U; Floege J; Boor P
- Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2014;189Tannenberg P; Chang Y-T; Gladh H; Tran P-K; Eriksson U; Folestad E; Tran-Lundmark K
- Conference publication: ANNALS OF ONCOLOGY. 2013;24:ix59FUNCTIONAL CHARACTERIZATION OF LATENT PDGFS VERSUS ACTIVATED PDGFS INDUCED BY PROTEOLYTIC PROCESSINGLi H; Eriksson U
- Conference publication: EUROPEAN HEART JOURNAL. 2013;34:440Kivela A; Heinonen SE; Leppanen P; Dijkstra MH; Gurzeler E; Huusko J; Olkkonen VM; Eriksson U; Jauhiainen M; Yla-Herttuala S
- Review: PHYSIOLOGY. 2013;28(2):125-134Hagberg C; Mehlem A; Falkevall A; Muhl L; Eriksson U
- Meeting abstract: CANCER RESEARCH. 2013;73:b28Roswell P; Haller K; Petersson A; Anderberg C; Li H; Norum J-H; Toftgard R; Eriksson U; Pietras K
- Conference publication: LABORATORY INVESTIGATION. 2011;91:141APinto A; Sujoy V; Eriksson U; Neville M; Nose V
- Conference publication: MODERN PATHOLOGY. 2011;24:141APinto A; Sujoy V; Eriksson U; Neville M; Nose V
- Conference publication: 2010;:a3962Johnson J; Folestad E; Eriksson U; Fuxe J
- Conference publication: EUROPEAN HEART JOURNAL. 2009;30:952Huusko JM; Merentie M; Dijkstra MH; Karvinen H; Vanwildemeersch M; Hedman M; Lipponen J; Eriksson U; Shibuya M; Yla-Herttuala S
- Published conference paper: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7(Suppl 1):155-158Su EJ; Fredriksson L; Schielke GP; Eriksson U; Lawrence DA
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2008;9(1):31Leppanen P; Heinonen SE; Olkkonen VM; Muilu M; Metso J; Eriksson U; Jauhianen M; Yla-Herttuala S
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2007;8(1):57Leppanen P; Koota S; Kholova I; Koponen J; Fieber C; Eriksson U; Alitalo K; Yla-Herttuala S
- Review: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(19):13001-13004Lidén M; Eriksson U
- Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2005;20:V8Eitner F; Bücher E; Rong S; Kunter U; Van Roeyen C; Eriksson U; Ostman A; Floege J
- Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2004;15(4):197-204Fredriksson L; Li H; Eriksson U
- Review: MOLECULAR ASPECTS OF MEDICINE. 2003;24(6):403-409Lidén M; Tryggvason K; Eriksson U
- Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2003;14(2):91-98Li X; Eriksson U
- Book chapter: ENCYCLOPEDIA OF HORMONES. 2003;p. 555-559Eriksson U; Li X
- Editorial comment: NATURE MEDICINE. 2002;8(8):775-777Eriksson U; Alitalo K
- Conference publication: FASEB JOURNAL. 2002;16(4):A212Gidlöf AC; Romert A; Törmä H; Eriksson U; Sirsjö A
- Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2001;21(4):714Gidlöf AC; Romert A; Eriksson U; Sirsjö A
- Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2001;33(4):421-426Li X; Eriksson U
- Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2000;316:344-358Simon A; Romert A; Eriksson U
- Review: CURRENT OPINION IN BIOTECHNOLOGY. 1999;10(6):528-535Olofsson B; Jeltsch M; Eriksson U; Alitalo K
- Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1999;237:41-57Eriksson U; Alitalo K
- Review: METHODS IN MOLECULAR BIOLOGY. 1998;89:57-66Eriksson U; Gustafsson AL
- Published conference paper: JOURNAL OF CELLULAR PHYSIOLOGY. 1997;173(2):211-215Joukov V; Kaipainen A; Jeltsch M; Pajusola K; Olofsson B; Kumar V; Eriksson U; Alitalo K
- Addendum: MECHANISMS OF DEVELOPMENT. 1996;60(2):241Gustafson AL; Donovan M; Annerwall E; Dencker L; Eriksson U
- Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1996;7:3461Simon A; Berrez JM; Gustafson AL; Eriksson U
- Published conference paper: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 1995;53(1-6):459-465Donovan M; Olofsson B; Gustafson AL; Dencker L; Eriksson U
- Other: NUTRITION REVIEWS. 1994;52(2):74-86NORUM K; JAMES P; ERIKSSON U; BLOMHOFF; ROSS C; DELUCA L; DREVON C; BUSCH C; MADEN M; MANGELSDORF D; CHYTIL F; DETHE H; WALD N; DOLL R; WILLETT WC; GREENWALD P; BRUCE A; WOLF G; OLSON JA; RUSSELL R; ROSENBERG I; UNDERWOOD B; GOPALAN C; MARTORELL R; ONG D; LIE S
- Book chapter: SUB-CELLULAR BIOCHEMISTRY. 1990;p. 365-399Eriksson U
- Book chapter: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 1990;p. 315-324Busch C; Sakena P; Funa K; Nordlinder H; Eriksson U
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Forskningsbidrag
- Swedish Cancer Society1 January 2023It is well documented that there is a close link between the onset of cancer and obesity/type 2 diabetes. The connection has been shown for cancer in the liver, pancreas, breast and in the gastrointestinal tract. Whether the cause is linked to high blood sugar or high blood fats is not known. We have developed mouse models to experimentally study the connections between obesity/type 2 diabetes and the onset of liver cancer. Many cancer patients suffer from a form of self-starvation called cachexia. It is not due to a lack of food intake, but the body's tissues break down for unknown reasons. We want to study the mechanisms that cause cachexia in cancer patients. We have developed mouse models to experimentally study the connections between obesity/type 2 diabetes and the onset of liver cancer. In mice fed a special fat-enriched diet, we can study fat accumulation in the liver and how this leads to the development of liver cancer. We have access to drugs that regulate fat accumulation in the liver and we want to study how these can affect the onset of liver cancer. Many cancer patients suffer from a form of self-starvation called cachexia. It is not due to a lack of food intake, but the body's tissues break down for unknown reasons. We want to experimentally study the mechanisms that give rise to cachexia in mouse models. With our research, we hope to increase knowledge about how liver cancer arises due to obesity and type 2 diabetes and how this knowledge can give us new drugs. Obesity and type 2 diabetes are increasing sharply in the population, we hope to be able to develop new forms of preventive treatment for the growing patient groups who are at risk of developing liver cancer. Our research regarding cancer cachexia is to understand the reasons why this serious condition develops in many cancer patients and what can be done to prevent the breakdown of fat and muscle in these patients. The goal is to prevent this 'self-starvation' from developing in cancer patients.
- Swedish Cancer Society1 January 2020It is well documented that there is a close link between the onset of cancer and obesity / type 2 diabetes. The association has been shown for cancer of the liver, pancreas, breasts and gastrointestinal tract. Whether the cause is linked to high blood sugar or high blood fats is not known. We have developed mouse models to experimentally study the associations between obesity / type 2 diabetes and the onset of liver cancer. Many cancer patients suffer from a form of self-starvation called cachexia. It is not due to lack of food intake but the body's tissues are broken down for unknown reasons. We want to study the mechanisms that give rise to cachexia in cancer patients. We have developed mouse models to experimentally study the associations between obesity / type 2 diabetes and the onset of liver cancer. In mice that receive a special fat-enriched diet, we can study fat accumulation in the liver and how this leads to the onset of liver cancer. We have access to drugs that regulate fat accumulation in the liver and we want to study how these can affect the onset of liver cancer. Many cancer patients suffer from a form of self-starvation called cachexia. It is not due to lack of food intake but the body's tissues are broken down for unknown reasons. We want to experimentally study the mechanisms that give rise to cachexia in mouse models. With our research, we hope to increase knowledge about how liver cancer arises due to obesity and type 2 diabetes and how this knowledge can give us new drugs. Given that obesity and type 2 diabetes are increasing sharply in the population, we hope to be able to develop new forms of treatment for the growing patient groups who are at risk of developing liver cancer. Our research on cancer cachexia is to understand the reasons why this serious condition develops and how to do to prevent the breakdown of fat and muscle in these patients.
- Metabolic aspects of cancer development and treatment with a focus on liver cancer and cachexiaSwedish Cancer Society1 January 2019It is well documented that there is a close link between the onset of cancer and obesity / type 2 diabetes. The association has been shown for cancer of the liver, pancreas, breasts and gastrointestinal tract. Whether the cause is linked to high blood sugar or high blood fats is not known. We have developed mouse models to experimentally study the associations between obesity / type 2 diabetes and the onset of liver cancer. Many cancer patients suffer from a form of self-starvation called cachexia. It is not due to lack of food intake but the body's tissues are broken down for unknown reasons. We want to study the mechanisms that give rise to cachexia in cancer patients. We have developed mouse models to experimentally study the associations between obesity / type 2 diabetes and the onset of liver cancer. In mice that receive a special fat-enriched diet, we can study fat accumulation in the liver and how this leads to the onset of liver cancer. We have access to drugs that regulate fat accumulation in the liver and we want to study how these can affect the onset of liver cancer. Many cancer patients suffer from a form of self-starvation called cachexia. It is not due to lack of food intake but the body's tissues are broken down for unknown reasons. We want to experimentally study the mechanisms that give rise to cachexia in mouse models. With our research, we hope to increase knowledge about how liver cancer arises due to obesity and type 2 diabetes and how this knowledge can give us new drugs. Given that obesity and type 2 diabetes are increasing sharply in the population, we hope to be able to develop new forms of treatment for the growing patient groups who are at risk of developing liver cancer. Our research on cancer cachexia is to understand the reasons why this serious condition develops and how to do to prevent the breakdown of fat and muscle in these patients.
- Role of VEGF-B i diabetic complicationsNovo Nordisk Foundation1 January 2018 - 1 January 2021
- Metabolic aspects of the onset and treatment of cancer with a focus on liver cancer and cachexiaSwedish Cancer Society1 January 2018It has been established that the development of liver cancer is closely associated with excessive calorie intake, obesity, the metabolic syndrome and the onset of type 2 diabetes. We want to investigate whether reducing the incidence of fat in liver in obese individuals can reduce the appearance of liver cancer. Many cancer patients suffer from a form of starvation symptoms during diseases called cachexia. This leads to muscle wasting, fatigue, severe reduction in quality of life, and impaired ability to be treated with certain cancer drugs. We want to investigate how the nutrient uptake from the blood vessels to the body's various tissues works at cachexia. Cancer research today often focuses on the genetic or other cause of the onset of cancer. There is less focus on the risks that one can influence through a healthy life. Obesity and type 2 diabetes lead to a greatly increased risk of developing cancer. We want to investigate how to reduce the development of liver cancer in obese and diabetic individuals by studying the corresponding mouse models. Furthermore, we want to understand how cancer patients with a form of self-starvation, who break down the muscles, called cachexia, can be offered a treatment that reduces the suffering in this sequelae of the cancer. Our research aims to investigate whether liver cancer can occur in patients with obesity, metabolic syndrome and type 2 diabetes by reducing morbid fat accumulation in the liver. Furthermore, we want to investigate why cancer patients with starvation cachexia do not get enough nutrition for their tissues and we will
- Swedish Research Council1 January 2018 - 31 December 2027Most human disease have a direct or indirect involvement with the vascular system in the body, and in many cases have an inadequate function of the vasculature has a direct role in morbidity and mortality of affected patients. An example is cardiovascular disease where the malfunction of the vasculature is a direct cause of the disease. Therefore, understanding the role of the vasculature in normal human physiology and human disease is of outmost importance.The inner lining of blood vessels, the endothelium, is the specialized interface between the blood stream and the organ parenchyma. The function of the endothelium in different organs is optimized to serve the physiological needs of the organ parenchyme and the specialization can be observed on both the structural level with continous, fenestrated and discontinous endothelium, as well as on the level of specifically expressed genes in endothelial cells in diferent vascular beds.In my research I focus on two different growth factor and how these factor in a paracrine fashion instructs the endothelium to serve tissue specific functions in different vascular beds. The focus is on VEGF-B and its role endothelial transcytosis of fatty acids, steatosis and in type 2 diabetes and its complications. I am also focusing on PDGF-C and its role on controlling the integrity and function of the blood-brain barrier under normal conditions and in CNS trauma, in particular in ischemic stroke.
- Role of VEGF-B signaling in diabetic complicationsNovo Nordisk Foundation1 January 2017 - 1 January 2018
- Metabolic aspects of the onset and treatment of cancer with a focus on liver cancer and cachexiaSwedish Cancer Society1 January 2017It has been established that the development of liver cancer is closely associated with excessive calorie intake, obesity, the metabolic syndrome and the onset of type 2 diabetes. We want to investigate whether reducing the incidence of fat in liver in obese individuals can reduce the appearance of liver cancer. Many cancer patients suffer from a form of starvation symptoms during diseases called cachexia. This leads to muscle wasting, fatigue, severe reduction in quality of life, and impaired ability to be treated with certain cancer drugs. We want to investigate how the nutrient uptake from the blood vessels to the body's various tissues works at cachexia. Cancer research today often focuses on the genetic or other cause of the onset of cancer. There is less focus on the risks that one can influence through a healthy life. Obesity and type 2 diabetes lead to a greatly increased risk of developing cancer. We want to investigate how to reduce the development of liver cancer in obese and diabetic individuals by studying the corresponding mouse models. Furthermore, we want to understand how cancer patients with a form of self-starvation, who break down the muscles, called cachexia, can be offered a treatment that reduces the suffering in this sequelae of the cancer. Our research aims to investigate whether liver cancer can occur in patients with obesity, metabolic syndrome and type 2 diabetes by reducing morbid fat accumulation in the liver. Furthermore, we want to investigate why cancer patients with starvation cachexia do not get enough nutrition for their tissues and we will
- Swedish Research Council1 January 2017 - 31 December 2017
- Swedish Research Council1 January 2017 - 31 December 2020
- Metabolic aspects of the onset and treatment of cancer with a focus on liver cancer and cachexiaSwedish Cancer Society1 January 2016It has been established that the development of liver cancer is closely associated with excessive calorie intake, obesity, the metabolic syndrome and the onset of type 2 diabetes. We want to investigate whether reducing the incidence of fat in liver in obese individuals can reduce the appearance of liver cancer. Many cancer patients suffer from a form of starvation symptoms during diseases called cachexia. This leads to muscle wasting, fatigue, severe reduction in quality of life, and impaired ability to be treated with certain cancer drugs. We want to investigate how the nutrient uptake from the blood vessels to the body's various tissues works at cachexia. Cancer research today often focuses on the genetic or other cause of the onset of cancer. There is less focus on the risks that one can influence through a healthy life. Obesity and type 2 diabetes lead to a greatly increased risk of developing cancer. We want to investigate how to reduce the development of liver cancer in obese and diabetic individuals by studying the corresponding mouse models. Furthermore, we want to understand how cancer patients with a form of self-starvation, who break down the muscles, called cachexia, can be offered a treatment that reduces the suffering in this sequelae of the cancer. Our research aims to investigate whether liver cancer can occur in patients with obesity, metabolic syndrome and type 2 diabetes by reducing morbid fat accumulation in the liver. Furthermore, we want to investigate why cancer patients with starvation cachexia do not get enough nutrition for their tissues and we will
- Importance of some growth factors in tumor biology, with particular focus on members of the VEGF / PDGF familySwedish Cancer Society1 January 2015All solid tumors consist of a mixture of tumor cells and normal cells, the so-called tumor tumor. Tumor metabolism consists of fibroblasts, inflammatory cells, and blood vessel cells. Tumor metabolism plays an important role when the tumor cells grow and spread. For example, the blood vessels must grow in step with the tumor, as the tumor otherwise dies of oxygen and nutrient deficiency. The reason why tumor tumors grow in step with the tumor is that tumor cells emit various types of growth factors, which stimulate the normal cells to migrate into the tumor and thus stimulate the tumor cells. own growth. The emergence of tumors also often results in tissue edema. This research project is about studying basic mechanisms that regulate how tumors grow and spread. Growth factors, a group of body proteins, have a crucial importance here. We also intend to develop and use monoclonal antibodies, which enable us to neutralize the effects of these factors. Increased knowledge of the signals that tumor cells use to direct normal cells into tumors, to form the necessary scans. tumor tomato may result in alternative treatment options. Furthermore, we want to study a mechanism that regulates edema formation in nerve tissue and possibly. also in tumors of the brain. We hope to show that a number of growth factors we isolated have an important role in tumor biology. We have developed monoclonal antibodies to these to be able to neutralize these factors in different tumor models and we now want to take another step by studying these factors in human tumors. We have also discovered a new mechanism for how cells, including tumor cells, obtain some necessary nutrients from the blood. Blocking this mechanism may affect tumor growth. We identified a new mechanism for how edema occurs in nerve tissue and this mechanism may have significance for how tumors in the brain should be treated.
- Importance of some growth factors in tumor biology, with particular focus on members of the VEGF / PDGF familySwedish Cancer Society1 January 2014All solid tumors consist of a mixture of tumor cells and normal cells, the so-called tumor tumor. Tumor metabolism consists of fibroblasts, inflammatory cells, and blood vessel cells. Tumor metabolism plays an important role when the tumor cells grow and spread. For example, the blood vessels must grow in step with the tumor, as the tumor otherwise dies of oxygen and nutrient deficiency. The reason why tumor tumors grow in step with the tumor is that tumor cells emit various types of growth factors, which stimulate the normal cells to migrate into the tumor and thus stimulate the tumor cells. own growth. The emergence of tumors also often results in tissue edema. This research project is about studying basic mechanisms that regulate how tumors grow and spread. Growth factors, a group of body proteins, have a crucial importance here. We also intend to develop and use monoclonal antibodies, which enable us to neutralize the effects of these factors. Increased knowledge of the signals that tumor cells use to direct normal cells into tumors, to form the necessary scans. tumor tomato may result in alternative treatment options. Furthermore, we want to study a mechanism that regulates edema formation in nerve tissue and possibly. also in tumors of the brain. We hope to show that a number of growth factors we isolated have an important role in tumor biology. We have developed monoclonal antibodies to these to be able to neutralize these factors in different tumor models and we now want to take another step by studying these factors in human tumors. We have also discovered a new mechanism for how cells, including tumor cells, obtain some necessary nutrients from the blood. Blocking this mechanism may affect tumor growth. We identified a new mechanism for how edema occurs in nerve tissue and this mechanism may have significance for how tumors in the brain should be treated.
- Swedish Research Council1 January 2012 - 31 December 2016
- VINNOVA1 July 2009 - 30 November 2014
- Swedish Research Council1 January 2009 - 31 December 2011
- Fondation Leducq1 January 2007Intracerebral hemorrhage (ICH), bleeding into the brain matter, is a particularly severe form of stroke that often leads to disability or death. It remains difficult to prevent and to treat. Although hypertension and other factors may play a role in the onset of ICH, in many cases no specific cause can be identified. Members of this network have independently shown that genetic susceptibility plays a role in some forms of ICH. Now, working together, the members of this network continue the systematic search for the genetic basis of ICH. The collaborative effort, among leaders in the field who have complementary areas of expertise, uses animal models, as well as samples from ICH patients, to investigate genes that control blood vessel function and maintenance in the brain. The ultimate objectives of network are to develop a diagnostic test for predisposition to ICH which might allow for preventive measures and effective treatment.
Anställningar
- Professor, Senior, Medicinsk biokemi och biofysik, Karolinska Institutet, 2024-2026
- Professor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2010-2024