Tomas Ekström

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2022;61(5):140
Altered expression of the IGF2-H19 locus and mitochondrial respiratory complexes in adrenocortical carcinoma
Scicluna P; Caramuta S; Kjellin H; Xu C; Froebom R; Akhtar M; Gao J; Shi H; Kjellman M; Almgren M; Hoog A; Zedenius J; Ekstroem TJ; Braenstroem R; Lui W-O; Larsson C
Article: BRAIN TUMOR PATHOLOGY. 2022;39(4):200-209
Loss of H3K27me3 in WHO grade 3 meningioma
Maier AD; Brochner CB; Mirian C; Haslund-Vinding J; Bartek JJ; Ekstrom TJ; Poulsen FR; Scheie D; Mathiesen T
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2022;66(6):638-647
Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells
Strom JE; Merid SK; Pourazar J; Blomberg A; Lindberg A; Ringh MV; Hagemann-Jensen M; Ekstrom TJ; Behndig AF; Melen E
Article: SCIENTIFIC REPORTS. 2022;12(1):470
Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy
Witasp A; Luttropp K; Qureshi AR; Barany P; Heimburger O; Wennberg L; Ekstrom TJ; Shiels PG; Stenvinkel P; Nordfors L
Article: MOLECULAR PSYCHIATRY. 2021;26(8):3884-3895
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
Jia T; Chu C; Liu Y; van Dongen J; Papastergios E; Armstrong NJ; Bastin ME; Carrillo-Roa T; den Braber A; Harris M; Jansen R; Liu J; Luciano M; Ori APS; Santianez RR; Ruggeri B; Sarkisyan D; Shin J; Sungeun K; Gutierrez DT; van't Ent D; Ames D; Artiges E; Bakalkin G; Banaschewski T; Bokde ALW; Brodaty H; Bromberg U; Brouwer R; Buchel C; Quinlan EB; Cahn W; de ZGI; Ehrlich S; Ekstrom TJ; Flor H; Frohner JH; Frouin V; Garavan H; Gowland P; Heinz A; Hoare J; Ittermann B; Jahanshad N; Jiang J; Kwok JB; Martin NG; Martinot J-L; Mather KA; McMahon KL; McRae AF; Nees F; Orfanos DP; Paus T; Poustka L; Samann PG; Schofield PR; Smolka MN; Stein DJ; Strike LT; Teeuw J; Thalamuthu A; Trollor J; Walter H; Wardlaw JM; Wen W; Whelan R; Apostolova LG; Binder EB; Boomsma DI; Calhoun V; Crespo-Facorro B; Deary IJ; Pol HH; Ophoff RA; Pausova Z; Sachdev PS; Saykin A; Wright MJ; Thompson PM; Schumann G; Desrivieres S
Article: MOLECULAR PSYCHIATRY. 2021;26(8):4367-4382
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence
Meng W; Sjoholm LK; Kononenko O; Tay N; Zhang D; Sarkisyan D; Geske JR; Ing A; Qiu W; Watanabe H; Almamoun R; Frieling H; Bleich S; Cui D; Biernacka JM; Mayfield RD; Dang Y; Karpyak VM; Schumann G; Bakalkin G; Ekstrom TJ; Ruegg J; Liu Y
Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026
Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking
Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Jagodic M; Ekstrom TJ; Ockinger J; Kular L
Article: BEHAVIOURAL BRAIN RESEARCH. 2020;382:112476
Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour
Checknita D; Bendre M; Ekstrom TJ; Comasco E; Tiihonen J; Hodgins S; Nilsson KW
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872
Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures
Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjoholm LK; Dahlstrom J; Sjoberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekstrom TJ; Bjorkholm M; Straat K
Article: EBIOMEDICINE. 2019;46:290-304
Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells
Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjoholm LK; Slavec L; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Ockinger J; Ekstrom TJ
Article: ONCOLOGY REPORTS. 2019;41(5):2927-2936
5-Azacytidine treatment results in nuclear exclusion of DNA methyltransferase-1, as well as reduced proliferation and invasion in human cytomegalovirus-infected glioblastoma cells
Estekizadeh A; Landazuri N; Pantalone MR; Davoudi B; Hu L-F; Nawaz I; Stragliotto G; Ekstraem TJ; Rahbar A
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2019;176(2):146-155
Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse
Tay N; Macare C; Liu Y; Ruggeri B; Jia T; Chu C; Biondo F; Ing A; Luo Q; Sarkysian D; Banaschewski T; Barker GJ; Bokde ALW; Bromberg U; Buchel C; Quinlan EB; Desrivieres S; Flor H; Frouin V; Garavan H; Gowland P; Heinz A; Ittermann B; Martinot J-L; Artiges E; Nees F; Orfanos DP; Paus T; Poustka L; Hohmann S; Frohner JH; Smolka MN; Walter H; Whelan R; Frieling H; Bleich S; Barker ED; Syvanen A-C; Ruegg J; Ekstrom TJ; Bakalkin G; Schumann G
Article: CANCER LETTERS. 2018;434:33-41
Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma
Yu J; Yuan X; Sjoholm L; Liu T; Kong F; Ekstrom TJ; Bjorkholm M; Xu D
Article: JOURNAL OF NEURAL TRANSMISSION. 2018;125(7):1053-1064
Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women
Checknita D; Ekstrom TJ; Comasco E; Nilsson KW; Tiihonen J; Hodgins S
Article: TRANSLATIONAL PSYCHIATRY. 2018;8(1):121
NR3C1 hypermethylation in depressed and bullied adolescents
Efstathopoulos P; Andersson F; Melas PA; Yang LL; Villaescusa JC; Ruegg J; Ekstrom TJ; Forsell Y; Galanti MR; Lavebratt C
Article: NATURE COMMUNICATIONS. 2018;9(1):2397
DNA methylation as a mediator of HLA-DRB1^☆15:01 and a protective variant in multiple sclerosis
Kular L; Liu Y; Ruhrmann S; Zheleznyakova G; Marabita F; Gomez-Cabrero D; James T; Ewing E; Linden M; Gornikiewicz B; Aeinehband S; Stridh P; Link J; Andlauer TFM; Gasperi C; Wiendl H; Zipp F; Gold R; Tackenberg B; Weber F; Hemmer B; Strauch K; Heilmann-Heimbach S; Rawal R; Schminke U; Schmidt CO; Kacprowski T; Franke A; Laudes M; Dilthey AT; Celius EG; Sondergaard HB; Tegner J; Harbo HF; Oturai AB; Olafsson S; Eggertsson HP; Halldorsson BV; Hjaltason H; Olafsson E; Jonsdottir I; Stefansson K; Olsson T; Piehl F; Ekstroem TJ; Kockum I; Feinberg AP; Jagodic M
Article: CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS. 2018;10:148-153
Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: Design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study
Wiik A; Andersson DP; Brismar TB; Chanpen S; Dhejne C; Ekstrom TJ; Flanagan JN; Holmberg M; Kere J; Lilja M; Lindholm ME; Lundberg TR; Maret E; Melin M; Olsson SM; Rullman E; Wahlen K; Arver S; Gustafsson T
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2018;52(4):1317-1327
Increased cytomegalovirus replication by 5-Azacytidine and viral-induced cytoplasmic expression of DNMT-1 in medulloblastoma and endothelial cells
Estekizadeh A; Landazur N; Bartek JJ; Brochner CB; Davoudi B; Broholm H; Karimi M; Ekstrom TJ; Rahbar A
Article: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2018;122(2):208-213
Evaluation of Post-Mortem Effects on Global Brain DNA Methylation and Hydroxymethylation
Sjoholm LK; Ransome Y; Ekstrom TJ; Karlsson O
Article: ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH. 2018;42(2):338-351
Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats
Feltmann K; Borroto-Escuela DO; Ruegg J; Pinton L; de Oliveira Sergio T; Narvaez M; Jimenez-Beristain A; Ekstrom TJ; Fuxe K; Steensland P
Article: SCIENTIFIC REPORTS. 2017;7(1):14589
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
Article: JOURNAL OF VIROLOGY. 2017;91(11):e02105-e02116
Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration
Engdahl E; Dunn N; Niehusmann P; Wideman S; Wipfler P; Becker AJ; Ekstrom TJ; Almgren M; Fogdell-Hahn A
Article: SCIENTIFIC REPORTS. 2017;7:46366
Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
Sanden E; Dyberg C; Krona C; Gallo-Oller G; Olsen TK; Perez JE; Wickstrom M; Estekizadeh A; Kool M; Visse E; Ekstrom TJ; Siesjo P; Johnsen JI; Darabi A
Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):71
DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis
Meng W; Zhu Z; Jiang X; Too CL; Uebe S; Jagodic M; Kockum I; Murad S; Ferrucci L; Alfredsson L; Zou H; Klareskog L; Feinberg AP; Ekstrom TJ; Padyukov L; Liu Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(9):E1678-E1687
Functional genomics analysis of vitamin D effects on CD4+T cells in vivo in experimental autoimmune encephalomyelitis
Zeitelhofer M; Adzemovic MZ; Gomez-Cabrero D; Bergman P; Hochmeister S; N'diaye M; Paulson A; Ruhrmann S; Almgren M; Tegner JN; Ekstrom TJ; Guerreiro-Cacais AO; Jagodic M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(52):E8472-E8481
Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide
Barde S; Ruegg J; Prud'homme J; Ekstrom TJ; Palkovits M; Turecki G; Bagdy G; Ihnatko R; Theodorsson E; Juhasz G; Diaz-Heijtz R; Mechawar N; Hokfelt TGM
Article: GENOME MEDICINE. 2016;8(1):124
High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis
Gomez-Cabrero D; Almgren M; Sjoholm LK; Hensvold AH; Ringh MV; Tryggvadottir R; Kere J; Scheynius A; Acevedo N; Reinius L; Taub MA; Montano C; Aryee MJ; Feinberg JI; Feinberg AP; Tegner J; Klareskog L; Catrina AI; Ekstrom TJ
Article: MOL NEUROPSYCHIATRY. 2015;1(2):76-81
Mood Stabilizers and the Influence on Global Leukocyte DNA Methylation in Bipolar Disorder.
Backlund L; Wei YB; Martinsson L; Melas PA; Liu JJ; Mu N; Östenson C-G; Ekström TJ; Schalling M; Lavebratt C
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1315:209-219
Global Analysis of DNA 5-Methylcytosine Using the Luminometric Methylation Assay, LUMA.
Luttropp K; Sjöholm LK; Ekström TJ
Article: EPIGENETICS. 2014;9(12):1557-1569
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training
Lindholm ME; Marabita F; Gomez-Cabrero D; Rundqvist H; Ekstrom TJ; Tegner J; Sundberg CJ
Article: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2014;211(5):502.e1-502.e8
Cesarean delivery and hematopoietic stem cell epigenetics in the newborn infant: implications for future health?
Almgren M; Schlinzig T; Gomez-Cabrero D; Gunnar A; Sundin M; Johansson S; Norman M; Ekstrom TJ
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2014;29(5):972-980
How can genetics and epigenetics help the nephrologist improve the diagnosis and treatment of chronic kidney disease patients?
Witasp A; Ekstrom TJ; Schalling M; Lindholm B; Stenvinkel P; Nordfors L
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2014;29(5):964-971
Novel insights from genetic and epigenetic studies in understanding the complex uraemic phenotype
Witasp A; Ekstrom TJ; Lindholm B; Stenvinkel P; Schalling M; Nordfors L
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(4):485-495
GeMes, Clusters of DNA Methylation under Genetic Control, Can Inform Genetic and Epigenetic Analysis of Disease
Liu Y; Li X; Aryee MJ; Ekstrom TJ; Padyukov L; Klareskog L; Vandiver A; Moore AZ; Tanaka T; Ferrucci L; Fallin MD; Feinberg AP
Article: CLINICAL EPIGENETICS. 2013;5(1):21
Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men
Gu T; Gu HF; Hilding A; Sjoholm LK; Ostenson C-G; Ekstrom TJ; Brismar K
Article: EPIGENETICS. 2013;8(3):333-346
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform
Marabita F; Almgren M; Lindholm ME; Ruhrmann S; Fagerstrom-Billai F; Jagodic M; Sundberg CJ; Ekstrom TJ; Teschendorff AE; Tegner J; Gomez-Cabrero D
Article: NATURE BIOTECHNOLOGY. 2013;31(2):142-147
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis
Liu Y; Aryee MJ; Padyukov L; Fallin MD; Hesselberg E; Runarsson A; Reinius L; Acevedo N; Taub M; Ronninger M; Shchetynsky K; Scheynius A; Kere J; Alfredsson L; Klareskog L; Ekstrom TJ; Feinberg AP
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2013;49(2):312-319
Ethanol Induces Epigenetic Modulation of Prodynorphin and Pronociceptin Gene Expression in the Rat Amygdala Complex
D'Addario C; Caputi FF; Ekstrom TJ; Di Benedetto M; Maccarrone M; Romualdi P; Candeletti S
Article: PLOS ONE. 2013;8(6):e66816
Dietary Alleviation of Maternal Obesity and Diabetes: Increased Resistance to Diet-Induced Obesity Transcriptional and Epigenetic Signatures
Attig L; Vige A; Gabory A; Karimi M; Beauger A; Gross M-S; Athias A; Gallou-Kabani C; Gambert P; Ekstrom TJ; Jais J-P; Junien C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2012;41(6):1959-1966
Cell type and context-specific function of PLAG1 for IGF2 P3 promoter activity
Akhtar M; Holmgren C; Gondor A; Vesterlund M; Kanduri C; Larsson C; Ekstrom TJ
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2012;30(6):1505-1511
Gemcitabine reactivates epigenetically silenced genes and functions as a DNA methyltransferase inhibitor
Gray SG; Baird A-M; O'Kelly F; Nikolaidis G; Almgren M; Meunier A; Dockry E; Hollywood D; Ekstrom TJ; Perry AS; O'Byrne KJ
Article: FASEB JOURNAL. 2012;26(6):2712-2718
Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
Melas PA; Rogdaki M; Osby U; Schalling M; Lavebratt C; Ekstrom TJ
Article: EPIGENETICS. 2012;7(6):585-593
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity
Esteki-Zadeh A; Karimi M; Straat K; Ammerpohl O; Zeitelhofer M; Jagodic M; Mehrab-Mohseni M; Sjoholm L; Rahbar A; Soderberg-Naucler C; Ekstrom TJ
Article: NEPHRON EXTRA. 2012;2(1):159-168
DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients.
Kato S; Lindholm B; Stenvinkel P; Ekström TJ; Luttropp K; Yuzawa Y; Yasuda Y; Tsuruta Y; Maruyama S
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2011;28(6):977-983
HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: Implications for the involvement of DNA methyltransferase
Khan Z; Akhtar M; Ekstrom TJ
Article: MOLECULAR ENDOCRINOLOGY. 2011;25(12):2017-2028
Epigenetic Regulation of Glucose Transporter 4 by Estrogen Receptor β
Ruegg J; Cai W; Karimi M; Kiss NB; Swedenborg E; Larsson C; Ekstrom TJ; Pongratz I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(44):18108-18113
Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse
Lindfors C; Nilsson IAK; Garcia-Roves PM; Zuberi AR; Karimi M; Donahue LR; Roopenian DC; Mulder J; Uhlen M; Ekstrom TJ; Davisson MT; Hokfelt TGM; Schalling M; Johansen JE
Article: MOLECULAR AND CELLULAR BIOLOGY. 2011;31(19):4119-4128
Genomic DNA Hypomethylation by Histone Deacetylase Inhibition Implicates DNMT1 Nuclear Dynamics
Arzenani MK; Zade AE; Ming Y; Vijverberg SJH; Zhang Z; Khan Z; Sadique S; Kallenbach L; Hu L; Vukojevic V; Ekstrom TJ
Article: BLOOD. 2011;118(13):3559-3569
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
Shaknovich R; Cerchietti L; Tsikitas L; Kormaksson M; De S; Figueroa ME; Ballon G; Yang SN; Weinhold N; Reimers M; Clozel T; Luttrop K; Ekstrom TJ; Frank J; Vasanthakumar A; Godley LA; Michor F; Elemento O; Melnick A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):208-212
Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models
Marino A-M; Sofiadis A; Baryawno N; Johnsen JI; Larsson C; Vukojevic V; Ekstrom TJ
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(3):843-849
Differential forms of p53 in medulloblastoma primary tumors, cell lines and xenografts
Philipova T; Baryawno N; Hartmann W; Pietsch T; Drud H; Johnsen JI; Ekstrom TJ
Article: FASEB JOURNAL. 2011;25(3):1069-1075
Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line
D'Addario C; Johansson S; Candeletti S; Romualdi P; Ogren SO; Terenius L; Ekstrom TJ
Article: METHODS IN MOLECULAR BIOLOGY. 2011;791:135-144
Global DNA methylation analysis using the Luminometric Methylation Assay.
Karimi M; Luttropp K; Ekström TJ
Article: PLOS ONE. 2010;5(12):e14398
Sex- and Diet-Specific Changes of Imprinted Gene Expression and DNA Methylation in Mouse Placenta under a High-Fat Diet
Gallou-Kabani C; Gabory A; Tost J; Karimi M; Mayeur S; Lesage J; Boudadi E; Gross M-S; Taurelle J; Vige A; Breton C; Reusens B; Remacle C; Vieau D; Ekstrom TJ; Jais J-P; Junien C
Article: NEURO-ONCOLOGY. 2010;12(6):549-558
Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy
Khan Z; Knecht W; Willer M; Rozpedowska E; Kristoffersen P; Clausen AR; Munch-Petersen B; Almqvist PM; Gojkovic Z; Piskur J; Ekstrom TJ
Article: LEUKEMIA. 2010;24(5):932-941
Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia
Deneberg S; Grovdal M; Karimi M; Jansson M; Nahi H; Corbacioglu A; Gaidzik V; Doehner K; Paul C; Ekstrom TJ; Hellstrom-Lindberg E; Lehmann S
Article: NEURO-ONCOLOGY. 2010;12(1):19-27
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma
Yin S; Girnita A; Stromberg T; Khan Z; Andersson S; Zheng H; Ericsson C; Axelson M; Nister M; Larsson O; Ekstrom TJ; Girnita L
Article: JOURNAL OF NEPHROLOGY. 2009;22(4):442-449
The epigenetic conductor: a genomic orchestrator in chronic kidney disease complications?
Ekstrom TJ; Stenvinkel P
Article: ACTA PAEDIATRICA. 2009;98(7):1096-1099
Epigenetic modulation at birth - altered DNA-methylation in white blood cells after Caesarean section
Schlinzig T; Johansson S; Gunnar A; Ekstrom TJ; Norman M
Article: NEUROSCIENCE LETTERS. 2009;457(1):8-11
Traumatic brain injury induces relocalization of DNA-methyltransferase 1
Lundberg J; Karimi M; von Gertten C; Holmin S; Ekstrom TJ; Sandberg-Nordqvist A-C
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2009;12(1):109-115
Dysregulation of cell death machinery in the prefrontal cortex of human alcoholics
Johansson S; Ekstrom TJ; Marinova Z; Okvist A; Sheedy D; Garrick T; Harper C; Kuzmin A; Yakovleva T; Bakalkin G
Article: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY. 2008;114(5):301-330
Characterization of a novel obesity phenotype caused by interspecific hybridization.
Singh U; Rizvi F; Yu Y; Shi W; Orth A; Karimi M; Ekström TJ; Plagge A; Kelsey G; Fundele R
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):389-394
Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma
Geli J; Kogner P; Lanner F; Natalishvili N; Juhlin C; Kiss N; Clark GJ; Ekstrom TJ; Farnebo F; Larsson C
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2008;299(24):2877-2883
Intra-individual change over time in DNA methylation with familial clustering
Bjornsson HT; Sigurdsson MI; Fallin MD; Irizarry RA; Aspelund T; Cui H; Yu W; Rongione MA; Ekstrom TJ; Harris TB; Launer LJ; Eiriksdottir G; Leppert MF; Sapienza C; Gudnason V; Feinberg AP
Article: ENDOCRINE-RELATED CANCER. 2008;15(2):609-621
Methylation of the p16^INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas
Kiss NB; Geli J; Lundberg F; Avci C; Velazquez-Fernandez D; Hashemi J; Weber G; Hoog A; Ekstrom TJ; Backdahl M; Larsson C
Article: CLINICAL CANCER RESEARCH. 2008;14(9):2551-2559
Global and regional CpG methylation in pheochromocytomas and abdominal paragangliomas:: Association to malignant behavior
Geli J; Kiss N; Karimi M; Lee J-J; Backdahl M; Ekstrom TJ; Larsson C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2008;32(4):821-827
HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin
Svechnikova I; Almqvist PM; Ekstrom TJ
Article: EXPERIMENTAL HEMATOLOGY. 2008;36(2):149-157
Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells
Khan R; Schmidt-Mende J; Karim M; Gogvadze V; Hassan M; Ekstrom TJ; Zhivotovsky B; Hellstrom-Lindberg E
Article: CKD-ASSOCIATED COMPLICATIONS: PROGRESS IN THE LAST HALF CENTURY. 2008;161:55-62
Epigenetics and the uremic phenotype:: A matter of balance
Stenvinkel P; Ekstrom TJ
Article: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 2008;22(1):17-23
Element distribution is altered in a zone surrounding human glioblastoma multiforme
Dehnhardt M; Zoriy MV; Khan Z; Reifenberger G; Ekstrom TJ; Becker JS; Zilles K; Bauer A
Article: PLOS ONE. 2007;2(9):e930
Neuroadaptations in Human Chronic Alcoholics: Dysregulation of the NF-κB System
Okvist A; Johansson S; Kuzmin A; Bazov I; Merino-Martinez R; Ponomarev I; Mayfield RD; Harris RA; Sheedy D; Garrick T; Harper C; Hurd YL; Terenius L; Ekstrom TJ; Bakalkin G; Yakovleva T
Article: JOURNAL OF NEUROSCIENCE. 2007;27(31):8226-8237
Control of chronic pain by the ubiquitin-proteasome system in the spinal cord
Ossipov MH; Bazov I; Gardell LR; Kowal J; Yakovleva T; Usynin I; Ekstrom TJ; Porreca F; Bakalkin G
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(13):2958-2967
HDAC inhibition amplifies gap junction communication in neural progenitors:: Potential for cell-mediated enzyme prodrug therapy
Khan Z; Akhtar M; Asklund T; Juliusson B; Almqvist PM; Ekstrom TJ
Article: JOURNAL OF INTERNAL MEDICINE. 2007;261(5):488-499
Impact of inflammation on epigenetic DNA methylation -: a novel risk factor for cardiovascular disease?
Stenvinkel P; Karimi M; Johansson S; Axelsson J; Suliman M; Lindholm B; Heimburger O; Barany P; Alvestrand A; Nordfors L; Qureshi AR; Ekstrom TJ; Schalling M
Article: BIOCHEMICAL PHARMACOLOGY. 2007;73(9):1297-1307
Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines
Ou J-N; Torrisani J; Unterberger A; Provencal N; Shikimi K; Karimi M; Ekstrom TJ; Szyf M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;354(2):466-471
p21^waf1/Cip1 partially mediates apoptosis in hepatocellular carcinoma cells
Svechnikova I; Ammerpohl O; Ekstrom TJ
Article: ENDOCRINE-RELATED CANCER. 2007;14(1):125-134
The Ras effectors NORE1A and RASSF1A are frequently inactivated in pheochromocytoma and abdominal paraganglioma
Geli J; Kiss N; Lanner F; Foukakis T; Natalishvili N; Larsson O; Kogner P; Hoog A; Clark GJ; Ekstrom TJ; Backdahl M; Farnebo F; Larsson C
Article: BRAIN RESEARCH. 2007;1132(1):20-28
Validation of endogenous controls for quantitative gene expression analysis:: Application on brain cortices of human chronic alcoholics
Johansson S; Fuchs A; Okvist A; Karimi M; Harper C; Garrick T; Sheedy D; Hurd Y; Bakalkin G; Ekstrom TJ
Article: FASEB JOURNAL. 2006;20(12):2124-2126
Prodynorphin storage and processing in axon terminals and dendrites
Yakovleva T; Bazov I; Cebers G; Marinova Z; Hara Y; Ahmed A; Vlaskovska M; Johansson BR; Hochgeschwender U; Singh IN; Bruce-Keller AJ; Hurd YL; Kaneko T; Terenius L; Ekstrom TJ; Hauser KF; Pickel VM; Bakalkin G
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(11):1989-1995
LUMA (LUminometric Methylation Assay) -: A high throughput method to the analysis of genomic DNA methylation
Karimi M; Johansson S; Stach D; Corcoran M; Grander D; Schalling M; Bakalkin G; Lyko F; Larsson C; Ekstrom TJ
Article: EPIGENETICS. 2006;1(1):45-48
Using LUMA A Luminometric-Based Assay for Global DNA-Methylation
Karimi M; Johansson S; Ekstrom TJ
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2005;26(5):1385-1391
Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas
Geli J; Nord B; Frisk T; Elder EE; Ekström TJ; Carling T; Bäckdahl M; Larsson C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;324(1):8-14
HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells
Ammerpohl O; Thormeyer D; Khan Z; Appelskog IB; Gojkovic Z; Almqvist PM; Ekström TJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;321(1):202-209
A novel soluble protein factor with non-opioid dynorphin A-binding activity
Marinova Z; Yakovleva T; Melzig MF; Hallberg M; Nylander I; Ray K; Rodgers DW; Hauser KF; Ekström TJ; Bakalkin G
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;24(6):1419-1425
Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells
Appelskog IB; Ammerpohl O; Svechnikova IG; Lui WO; Almqvist PM; Ekström TJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;318(2):615-624
YY1 binding to a subset of p53 DNA-target sites regulates p53-dependent transcription
Yakovleva T; Kolesnikova L; Vukojevic V; Gileva I; Tan-No K; Austen M; Lüscher B; Ekström TJ; Terenius L; Bakalkin G
Article: EUROPEAN JOURNAL OF CANCER. 2004;40(7):1073-1081
Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells
Asklund T; Appelskog IB; Ammerpohl O; Ekström TJ; Almqvist PM
Article: EXPERIMENTAL CELL RESEARCH. 2003;284(2):185-195
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene
Asklund T; Appelskog IB; Ammerpohl O; Langmoen IA; Dilber MS; Aints A; Ekström TJ; Almqvist PM
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2003;22(3):579-588
Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate
Svechnikova I; Gray SG; Kundrotiene J; Ponthan F; Kogner P; Ekström TJ
Article: TRENDS IN BIOCHEMICAL SCIENCES. 2002;27(12):612-618
p53 latency -: out of the blind alley
Yakovleva T; Pramanik A; Terenius L; Ekström TJ; Bakalkin G
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2002;9(6):645-649
Altered expression of low affinity insulin-like growth factor binding protein related proteins in hepatoblastoma
Von Horn H; Hwa V; Rosenfeld RG; Hall K; Teh BT; Tally M; Ekström TJ; Gray SG
Article: JOURNAL OF ENDOCRINOLOGY. 2002;172(3):457-465
GH is a regulator of IGF2 promoter-specific transcription in human liver
von Horn H; Ekström C; Ellis E; Olivecrona H; Einarsson C; Tally M; Ekström TJ
Article: VIRCHOWS ARCHIV. 2001;439(6):803-807
Promoter-specific transcription of the IGF2 gene: a novel rapid, non-radioactive and highly sensitive protocol for mRNA analysis.
Hartmann W; Waha A; Koch A; Albrecht S; Gray SG; Ekström TJ; von Schweinitz D; Pietsch T
Article: EXPERIMENTAL CELL RESEARCH. 2001;270(1):88-95
Methylation changes in the human IGF2 P3 promoter parallel IGF2 expression in the primary tumor, established cell line, and xenograft of a human hepatoblastoma
Eriksson T; Frisk T; Gray SG; von Schweinitz D; Pietsch T; Larsson C; Sandstedt B; Ekström TJ
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2001;19(4):773-777
Differential expression of class IHDACs:: Roles of cell density and cell cycle
Dangond F; Henriksson M; Zardo G; Caiafa P; Ekström TJ; Gray SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(19):15650-15658
p53 latency -: C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences
Yakovleva T; Pramanik A; Kawasaki T; Tan-No K; Gileva I; Lindgren H; Langel Ü; Ekström TJ; Rigler R; Terenius L; Bakalkin G
Article: CANCER LETTERS. 2001;162(2):253-260
Expression levels of insulin-like growth factor binding proteins and insulin receptor isoforms in hepatoblastomas
von Horn H; Tally M; Hall K; Eriksson T; Ekström TJ; Gray SG
Article: BRITISH JOURNAL OF CANCER. 2000;83(8):1020-1025
Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas
Gray SG; Kytölä S; Matsunaga T; Larsson C; Ekström TJ
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;6(2):161-169
Expression of genes involved with cell cycle control, cell growth and chromatin modification are altered in hepatoblastomas
Gray SG; Hartmann W; Eriksson T; Ekström C; Holm S; Kytölä S; von Schweinitz D; Pietsch T; Larsson C; Kogner P; Sandstedt B; Ekström TJ
Article: CYTOKINE. 2000;12(7):1104-1109
IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin A
Gray SG; Svechnikova I; Hartmann W; O'Connor L; Aguilar-Santelises M; Ekström TJ
Article: BRITISH JOURNAL OF CANCER. 2000;82(9):1561-1567
Altered expression of members of the IGF-axis in hepatoblastomas
Gray SG; Eriksson T; Ekström C; Holm S; von Schweinitz D; Kogner P; Sandstedt B; Pietsch T; Ekström TJ
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(1):33-41
Modulating IGFBP-3 expression by trichostatin A:: Potential therapeutic role in the treatment of hepatocellular carcinoma
Gray SG; Kytölä S; Lui WO; Larsson C; Ekström TJ
Article: EXPERIMENTAL CELL RESEARCH. 1999;253(2):618-628
IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells.
Gray SG; Yakovleva T; Hartmann W; Tally M; Bakalkin G; Ekström TJ
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 1999;84(2):553-560
Acute and short-term effects of growth hormone on insulin-like growth factors and their binding proteins:: Serum levels and hepatic messenger ribonucleic acid responses in humans
Olivecrona H; Hilding A; Ekström C; Barle H; Nyberg B; Möller C; Delhanty PJ; Baxter RC; Angelin B; Ekström TJ; Tally M
Article: GENOMICS. 1998;52(2):245-246
Human histone deacetylase 2, HDAC2 (human RPD3), is localized to 6q21 by radiation hybrid mapping
Betz R; Gray SG; Ekström C; Larsson C; Ekström TJ
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1998;42(5):687-693
Developmental-dependent DNA methylation of the IGF2 and H19 promoters is correlated to the promoter activities in human liver development.
Li X; Gray SG; Flam F; Pietsch T; Ekström TJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(11):6145-6150
In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation
Islam MS; Leibiger I; Leibiger B; Rossi D; Sorrentino V; Ekström TJ; Westerblad H; Andrade FH; Berggren PO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998;245(2):423-427
Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells.
Gray SG; Ekström TJ
Article: INTERNATIONAL JOURNAL OF CANCER. 1998;75(2):176-180
Promoter-specific methylation and expression alterations of igf2 and h19 are involved in human hepatoblastoma
Li XR; Kogner P; Sandstedt B; Haas OA; Ekström TJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;239(3):878-883
Novel splicing of an IGF2 polymorphic region in Human adrenocortical carcinomas
Gray SG; Kjellman M; Larsson C; Ekstrom TJ
Article: CANCER RESEARCH. 1997;57(10):2048-2054
Disrupted IGF2 promoter control by silencing of promoter P1 in human hepatocellular carcinoma
Li XR; Nong Z; Ekstrom C; Larsson E; Nordlinder H; Hofmann WJ; Trautwein C; Odenthal M; Dienes HP; Ekstrom TJ; Schirmacher P
Article: JOURNAL OF ENDOCRINOLOGY. 1996;149(1):117-124
Expression levels of the insulin-like growth factor-II gene (IGF2) in the human liver: Developmental relationships of the four promoters
Li X; Cui H; Sandstedt B; Nordlinder H; Larsson E; Ekstrom TJ
Article: ONCOGENE. 1995;11(2):221-229
EXPRESSION, PROMOTER USAGE AND PARENTAL IMPRINTING STATUS OF INSULIN-LIKE GROWTH-FACTOR-II (IGF2) IN HUMAN HEPATOBLASTOMA - UNCOUPLING OF IGF2 AND H19 IMPRINTING
LI XR; ADAM G; CUI HM; SANDSTEDT B; OHLSSON R; EKSTROM TJ
Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 1995;41(2):177-183
MONOALLELIC EXPRESSION OF IGF2 AT THE HUMAN FETAL MATERNAL BOUNDARY
EKSTROM TJ; CUI HM; NYSTROM A; RUTANEN EM; OHLSSON R
Article: DEVELOPMENT. 1995;121(2):309-316
PROMOTER-SPECIFIC IGF2 IMPRINTING STATUS AND ITS PLASTICITY DURING HUMAN LIVER DEVELOPMENT
EKSTROM TJ; CUI HM; OHLSSON R
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Corrigendum: BEHAVIOURAL BRAIN RESEARCH. 2020;393:112721
Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour (vol 382, 112476, 2020)
Checknita D; Bendre M; Ekstrom TJ; Comasco E; Tiihonen J; Hodgins S; Nilsson KW
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):4340
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship (vol 7, 14589, 2017)
Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
Review: CLINICAL SCIENCE. 2017;131(14):1649-1667
Current epigenetic aspects the clinical kidney researcher should embrace
Witasp A; Van Craenenbroeck AH; Shiels PG; Ekstrom TJ; Stenvinkel P; Nordfors L
Letter: SEMINARS IN IMMUNOPATHOLOGY. 2017;39(4):421-422
Comment on "Epigenetics in the pathogenesis of RA"
Gomez-Cabrero D; Tegner J; Ekstrom TJ; Ospelt C
Letter: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 2013;73(2):184-185
Physical activity is associated with decreased global DNA methylation in Swedish older individuals
Luttropp K; Nordfors L; Ekstrom TJ; Lind L
Editorial comment: EPIGENOMICS. 2012;4(4):359-362
The importance of epigenomic studies in schizophrenia
Ekstrom TJ; Lavebratt C; Schalling M
Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(6):757-765
Epigenetic regulation in obesity
Lavebratt C; Almgren M; Ekstrom TJ
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2011;1230:E29-E36
Epigenetic mechanisms as targets and companions of viral assaults
Ernberg I; Karimi M; Ekstrom TJ
Meeting abstract: PHARMACOLOGICAL REPORTS. 2011;63(1):208-209
A role for epigenetic mechanisms in the regulation of prodynorphin expression by alcohol
D'Addario C; Caputi FF; Candeletti S; Ogren SO; Terenius L; Ekstrom T; Maccarrone M; Romualdi P
Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1790(9):845-846
Epigenetic control of gene expression Preface
Ekstrom TJ
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S647
Prodynorphin gene regulation by epigenetic mechanisms following ethanol and acetaldehyde exposure in SH-MY cells
D'Addario C; Ekstrom T; Ogren SO; Romualdi P; Terenius L
Published conference paper: JOURNAL OF RENAL NUTRITION. 2009;19(1):82-85
Does the Uremic Milieu Affect the Epigenotype?
Stenvinkel P; Ekstrom TJ
Review: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2008;23(5):1493-1496
Epigenetics -: a helpful tool to better understand processes in clinical nephrology?
Stenvinkel P; Ekstrom TJ
Meeting abstract: LEUKEMIA RESEARCH. 2007;31:S62-S63
Hypomethylation and apoptosis in 5-azacytidine treated myeloid cells
Khan R; Schmidt-Mende J; Karimi M; Forsblom A-M; Gogvadze V; Hassan M; Ekstrom TJ; Zhivotovsky B; Hellstrom-Lindberg E
Review: EXPERIMENTAL CELL RESEARCH. 2001;262(2):75-83
The human histone deacetylase family.
Gray SG; Ekström TJ
Corrigendum: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(5):557
Methylation, gene expression and the chromatin connection in cancer (review) (vol 4, pg 333, 1999)
Gray SG; Eriksson T; Ekstrom TJ
Review: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 1999;4(4):333-350
Methylation, gene expression and the chromatin connection in cancer (review)
Gray SG; Eriksson T; Ekström TJ

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Professor Emeritus/Emerita, Molekylär medicin och kirurgi, Karolinska Institutet, 2022-2025

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Docent, Inriktning molekylär cellbiologi, Karolinska institutet, 1993

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