Theo Gulen
Anknuten till Forskning | Docent
Klinisk forskare med internationellt erkänd expertis inom mastcellssjukdomar som SM och MCAS
leder forskning via ett unikt longitudinellt register med över 900 patienter.
E-postadress: theo.gulen@ki.se
Besöksadress: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postadress: H7 Medicin, Huddinge, H7 CIM Mjösberg, 171 77 Stockholm
Forskningsbeskrivning
Mekanismer och biomarkörer för mastcellsaktivering vid anafylaxi, MCAS och mastocytos
Vår forskning utforskar varför mastceller blir dysreglerade och varför mastcellsjukdomar ger så varierande kliniska uttryck. Genom att kombinera kliniska data, proteomik och funktionella mastcellsanalyser identifierar vi biomarkörer och endotyper kopplade till svår anafylaxi och mastcellsaktivering. Målet är att förbättra riskprediktion och möjliggöra mer individanpassad diagnostik och behandling vid MCAS, systemisk mastocytos och andra mastcellsrelaterade tillstånd.
Utvalda publikationer
- Journal article: IMMUNOTARGETS AND THERAPY. 2026;15:609692-20Gulen T; Sabato V
- Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2026;26(1):19Rama TA; Gulen T
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2026;14(1):19-28Akin C; Gulen T; Castells MC; Elberink HO; Valent P
- Editorial: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2025;135(1):33-36Gulen T; Akin C
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(7):1850-1862.e1Beyens M; Sabato V; Ebo DG; Zaghmout T; Gulen T
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(3):753-761Zaghmout T; Maclachlan L; Bedi N; Guelen T
- Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2024;24(2):39-51Gulen T
- Review: DIAGNOSTICS. 2023;13(24):3662Beyens M; Toscano A; Ebo D; Guelen T; Sabato V
- Article: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. 2023;43(4):681-698Gulen T
- Review: DIAGNOSTICS. 2023;13(21):3307Gulen T
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2023;11(10):3010-3020Valent P; Hoermann G; Bonadonna P; Hartmann K; Sperr WR; Broesby-Olsen S; Brockow K; Niedoszytko M; Hermine O; Chantran Y; Butterfield JH; Greiner G; Carter MC; Sabato V; Radia DH; Siebenhaar F; Triggiani M; Guellen T; Alvarez-Twose I; Staudinger T; Traby L; Sotlar K; Reiter A; Horny H-P; Orfao A; Galli SJ; Schwartz LB; Lyons JJ; Gotlib J; Metcalfe DD; Arock M; Akin C
- Article: DIAGNOSTICS. 2023;13(13):2241Jarkvist J; Gulen T
- Article: BLOOD ADVANCES. 2023;7(9):1713-1724Kennedy VE; Perkins C; Reiter A; Jawhar M; Luebke J; Kluin-Nelemans HC; Shomali W; Langford C; Abuel J; Hermine O; Niedoszytko M; Gorska A; Mital A; Bonadonna P; Zanotti R; Tanasi I; Mattsson M; Hagglund H; Triggiani M; Yavuz AS; Panse J; Christen D; Heizmann M; Shoumariyeh K; Mueller S; Elena C; Malcovati L; Fiorelli N; Wortmann F; Vucinic V; Brockow K; Fokoloros C; Papageorgiou SG; Breynaert C; Bullens D; Doubek M; Ilerhaus A; Angelova-Fischer I; Solomianyi O; Varkonyi J; Sabato V; Ruefer A; Schug TD; Hermans MAW; Fortina AB; Caroppo F; Bumbea H; Gulen T; Hartmann K; Elberink HO; Schwaab J; Arock M; Valent P; Sperr WR; Gotlib J
- Article: FRONTIERS IN ALLERGY. 2022;3:1071807Bonadonna P; Olivieri F; Jarkvist J; Nalin F; Zanotti R; Maclachlan L; Gulen T
- Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2022;88(11):4845-4853Kowalik A; de Monestrol I; Sorjonen K; Brockow K; Gulen T
- Article: CANCERS. 2022;14(16):3942Ungerstedt J; Ljung C; Klimkowska M; Gulen T
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(8):1941-1950Valent P; Hartmann K; Bonadonna P; Gulen T; Brockow K; Alvarez-Twose I; Hermine O; Niedoszytko M; Carter MC; Hoermann G; Butterfield JH; Lyons JJ; Sperr WR; Greiner G; Sotlar K; Kluin-Nelemans HC; Schwaab J; Lange M; George TI; Siebenhaar F; Broesby-Olsen S; Jawhar M; Nedoszytko B; Castells M; Orfao A; Gotlib J; Reiter A; Horny H-P; Triggiani M; Arock M; Metcalfe DD; Akin C
- Article: ALLERGY. 2022;77(8):2292-2312Barbaud A; Garvey LH; Arcolaci A; Brockow K; Mori F; Mayorga C; Bonadonna P; Atanaskovic-Markovic M; Moral L; Zanoni G; Pagani M; Soria A; Jost M; Caubet J-C; Carmo A; Mona A-A; Alvarez-Perea A; Bavbek S; Benedetta B; Bilo MB; Blanca-Lopez N; Bogas HG; Buonomo A; Calogiuri G; Carli G; Cernadas J; Cortellini G; Celik G; Demir S; Dona I; Dursun AB; Eberlein B; Faria E; Fernandes B; Garcez T; Garcia-Nunez I; Gawlik R; Gelincik A; Gomes E; Gooi JHC; Grosber M; Gulen T; Hacard F; Hoarau C; Janson C; Johnston SL; Joerg L; Ozdemir SK; Klimek L; Kosnik M; Kowalski ML; Kuyucu S; Kvedariene V; Laguna JJ; Lombardo C; Marinho S; Merk H; Meucci E; Morisset M; Munoz-Cano R; Murzilli F; Nakonechna A; Popescu F-D; Porebski G; Radice A; Regateiro FS; Rockmann H; Romano A; Sargur R; Sastre J; Hofmeier KS; Sedlackova L; Sobotkova M; Terreehorst I; Treudler R; Walusiak-Skorupa J; Wedi B; Wohrl S; Zidarn M; Zuberbier T; Agache I; Torres MJ
- Letter: ALLERGY. 2022;77(6):1909-1911Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarityLyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T; Nilsson G
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(5):1377-1379Lazarinis N; Bossios A; Gulen T
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Artiklar
- Journal article: WORLD ALLERGY ORGANIZATION JOURNAL. 2026;19(10):101470Giavina-Bianchi P; Giavina-Bianchi M; Morais-Almeida M; Alvarez-Twose I; Bernstein JA; Broesby-Olsen S; Castells M; Gulen T; Hartmann K; Orfao A; Pongdee T; Rama TA; Siebenhaar F; Varricchi G; Martin BL; Fiocchi A; Wong GW-K; Ansotegui IJ; Akin C
- Journal article: EXPERIMENTAL HEMATOLOGY & ONCOLOGY. 2026;15(1):79Haug S; Sperr WR; Wehr C; Bonofiglio F; Klein SK; Kluin-Nelemans HC; Mulder AB; Hermine O; Rossignol J; Suarez F; Marcais A; Shomali W; Perkins C; Christen D; Rabitsch W; Hadzijusufovic E; Voglova J; Jentzsch M; Schwaab J; Lubke J; Mattsson M; Hagglund H; Dybedal I; Baffoe D; Bonnadonna P; Bonifacio M; Tanasi I; Sciume M; Niedoszytko M; Gorska A; Mital A; Triggiani M; Parente R; Yavuz AS; Elena C; Malcovati L; Ferrari J; Wortmann F; Brockow K; Franz TM; Makris M; Papageorgiou SG; Breynaert C; Ieven T; Angelova-Fischer I; Stefan A; Varkonyi J; Sabato V; Schug TD; van Daele PLA; Fortina AB; Caroppo F; Gulen T; Heizmann M; Hartmann K; Rufer A; Doubek M; Panse J; Gotlib J; Arock M; Oude Elberink HNG; Reiter A; Valent P; Shoumariyeh K
- Article: ALLERGY. 2026;81(8):2713-2725Rama TA; Gulen T; Brockow K; Bonadonna P; Sabato V; Grattan CE; Broesby-Olsen S; Altrichter S; Siebenhaar F; Walusiak-Skorupa J; Gonzalez-de-Olano D
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: GLOBAL. 2026;5(4):100699Johnsson A-K; Atanasoai I; Nilsson G; Gulen T
- Journal article: JOURNAL OF HEMATOLOGY & ONCOLOGY. 2026;19(1):66Hermine O; Debeaupuis O; Damaj G; Lubke J; Schwaab J; Heizmann M; Siebenhaar F; Pyatilova P; Nojarov N; Niedoszytko M; Gorska A; Mattsson M; Shoumariyeh K; de Bra S; Wortmann F; von Bubnoff N; Bumbea H; Soare D; Elena C; Varkonyi J; Fortina AB; Erdem S; Brockow K; Franz TM; Panse J; Christen D; Breynaert C; Yavuz AS; Malcovati L; Doubek M; Sabato V; Tanasi I; Bonifacio M; Hartmann K; Rufer A; Sciume M; Bellani V; Angelova-Fischer I; Stefan A; Triggiani M; Parente R; Klein SK; Makris M; Papageorgiou S; van Daele P; Dybedal I; Baffoe D; Gulen T; Jentzsch M; Lortholary O; Heiblig M; Livideanu CB; Barete S; Gourguechon C; Dimicoli-Salazar S; Tournilhac O; Frenzel L; Arock M; Mital A; Woltsche JN; Kluin-Nelemans HC; Elberink JNGO; Gotlib J; Sperr M; Reiter A; Valent P; Sperr WR; Rossignol J
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2026;14(6):1466Akin C; Gulen T; Castells MC; Valent P
- Article: LAKARTIDNINGEN. 2025;122:25132[Updated guidelines for anaphylaxis management - simplified structures for enhanced patient safety].Gülen T
- Article: LEUKEMIA. 2025;39(3):675-683Ruefer A; Nilius H; Hermine O; Niedoszytko M; Oude Elberink JNG; Bonadonna P; Shoumariyeh K; Gulen T; Hartmann K; Sabato V; Angelova-Fischer I; Baffoe D; Christen D; Belloni Fortina A; Breynaert C; Brockow K; von Bubnoff N; Bumbea H; van Daele P; Doubek M; Dybedal I; Elena C; Fokoloros C; Gorska A; Heizmann M; Jentzsch M; Klein S; Luebke J; Mattsson M; Mulder A; Panse J; Schug TD; Sciume M; Stefan A; Sztormowska M; Varkonyi J; Wortmann F; Yavuz AS; Sperr M; Gotlib J; Reiter A; Triggiani M; Sperr WR; Valent P
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(12):3250-3260.e5Valent P; Hartmann K; Hoermann G; Reiter A; Alvarez-twose I; Brockow K; Bonadonna P; Hermine O; Niedoszytko M; Carter MC; Butterfield JH; Siebenhaar F; Zanotti R; Radia DH; Castells M; Sperr WR; Broesby-Olsen S; Triggiani M; Schwartz LB; George TI; Gulen T; Sotlar K; Gotlib J; Galli SJ; Horny H-P; Metcalfe DD; Orfao A; Arock M; Akin C
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2023;11(6):1706-1717Valent P; Hartmann K; Bonadonna P; Sperr W; Niedoszytko M; Kluin-Nelemans HC; Hermine O; Sotlar K; Hoermann G; Nedoszytko B; Broesby-Olsen S; Zanotti R; Lange M; Doubek M; Brockow K; Alvarez-Twose I; Varkonyi J; Yavuz S; Nilsson G; Radia D; Grattan C; Schwaab J; Gillen T; Elberink HNGO; Haegglund H; Siebenhaar F; Hadzijusufovic E; Sabato V; Mayer J; Reiter A; Orfao A; Horny H-P; Triggiani M; Arock M
- Journal article: JOURNAL OF CYSTIC FIBROSIS. 2022;21:s108Kowalik A; de Monestrol I; Sorjonen K; Gülen T
- Article: ACTA DERMATO-VENEREOLOGICA. 2016;96(5):602-612Broesby-Olsen S; Dybedal I; Gulen T; Kristensen TK; Moller MB; Ackermann L; Saaf M; Karlsson M; Agertoft L; Brixen K; Hermann P; Stylianou E; Mortz CG; Torfing T; Havelund T; Sander B; Bergstrom A; Bendix M; Garvey LH; Weis Bjerrum O; Valent P; Bindslev-Jensen C; Nilsson G; Vestergaard H; Hagglund H
- Article: ACTA DERMATO-VENEREOLOGICA. 2014;94(5):583-584Hagglund H; Sander B; Gulen T; Lindelof B; Nilsson G
- Article: MEDICAL ONCOLOGY. 2014;31(8):123Hagglund H; Sander B; Ahmadi A; Gulen T; Nilsson G
- Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2013;3(1):22Gülen T; Dahlén B; Sander B; Hägglund H; Nilsson G
- Article: MEDICAL ONCOLOGY. 2012;29(5):3540-3546Gulen T; Sander B; Nilsson G; Palmblad J; Sotlar K; Horny H-P; Hagglund H
- Journal article: EUROPEAN RESPIRATORY JOURNAL. 2011;38(Suppl 55):p3348Larsson J; Balgoma D; Delin I; Gülen T; Nilsson G; Hägglund H; Daham K; Lawson J; FitzGerald G; Dahlén B; Wheelock C; Dahlén S-E
- Article: LAKARTIDNINGEN. 2007;104(24-25):1881-1882Shemais H; Hot-Bjelak A; Pavlakovic ST; Gülen T
Alla övriga publikationer
- Preprint: RESEARCH SQUARE. 2024Rüfer A; Nilius H; Hermine O; Niedoszytko M; Elberink HO; Bonadonna P; Shoumariyeh K; Gulen T; Hartmann K; Sabato V; Angelova-Fischer I; Baffoe D; Fortina AB; Breynaert C; Brockow K; von Bubnoff N; Bumbea H; Daele PV; Doubek M; Dybedal I; ELENA C; Fokoloros C; Górska A; Heizmann M; Jentzsch M; Luebcke J; Mattsson M; Panse J; Shug T; Sciumè M; Stefan A; Sztormowska M; Várkonyi J; Wortmanns F; Yavuz A; Sperr M; Gotlib J; Reiter A; Triggiani M; Sperr W; Valent P
- Conference publication: ALLERGY. 2023;78:34Jarkvist J; Gulen T
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(8):2015-2024Pyatilova P; Akin C; Alvarez-Twose I; Arock M; Bonadonna P; Brockow K; Butterfield JH; Broesby-Olsen S; Carter MC; Castells M; George TI; Gotlib J; Greiner G; Gulen T; Hartmann K; Hermine O; Horny H-P; Jawhar M; Lange M; Lyons JJ; Maurer M; Metcalfe DD; Nedoszytko B; Niedoszytko M; Orfao A; Reiter A; Schwaab J; Sotlar K; Sperr WR; Triggiani M; Valent P; Siebenhaar F
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(4):1128Gulen T; Akin C; Metcalfe DD; Valent P
- Preprint: AUTHOREA PREPRINTS. 2021Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarityNilsson G; Lyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T
- Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2021;21(2):11Gulen T; Akin C
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1454Romantowski J; Gorska A; Niedoszytko M; Gulen T; Gruchala-Niedoszytko M; Nedoszytko B; Lange M; Brockow K; Arock M; Akin C; Valent P
- Conference publication: PEDIATRIC PULMONOLOGY. 2020;55:S251Kowalik A; Gulen T; de Monestrol I
- Conference publication: ALLERGY. 2020;75:195-196Jarkvist J; Brockow K; Gulen T
- Book chapter: MASTOCYTOSIS. 2020;p. 141-155Gülen T; Oude Elberink JNG; Brockow K
- Conference publication: ALLERGY. 2019;74:670Jarkvist J; Bonadonna P; Gulen T
- Conference publication: ALLERGY. 2018;73:69Salehi C; Jarkvist J; Nilsson G; Akin C; Gulen T
- Editorial: ACTA DERMATO-VENEREOLOGICA. 2018;98(1):149-150Guelen T; Akin C
- Conference publication: ALLERGY. 2017;72:445Gulen T; Lyberg K; Westerberg MC; Ekoff M; Alexeyenko A; Dahlen B; Nilsson G
- Review: LAKARTIDNINGEN. 2016;113:D7CIGülen T; Björkander J
- Conference publication: ALLERGY. 2016;71:77Ljung C; Nilsson G; Akin C; Gulen T
- Review: LAKARTIDNINGEN. 2016;113:DTEDGülen T; Wickman M
- Conference publication: ALLERGY. 2015;70:72Gulen T; Moller-Westerberg C; Lyberg K; Kolmert J; Bood J; Dahlen S-E; Dahlen B; Nilsson G
- Editorial: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(9):1099Zhang X-Y; Ziyab A; Guelen T
- Conference publication: ALLERGY. 2014;69:13Gulen T; Westerberg MC; Kolmert J; Larsson J; Dahlen S-E; Dahlen B; Nilsson G
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Forskningsbidrag
- Recurrent Anaphylaxis: Can We Predict Who Is at Risk?Svenska föreningen för Allergologi1 januari 2025
- Swedish Heart-Lung Foundation1 januari 2022 - 31 december 2024
Anställningar
- Anknuten till Forskning, Medicin, Huddinge, Karolinska Institutet, 2024-2027
- Anknuten till Forskning, Medicin Solna, Karolinska Institutet, 2023-2027
Examina och utbildning
- Docent, Allergologi, Karolinska Institutet, 2023
- Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2014