Theo Gulen
Anknuten till Forskning | Docent
E-postadress: theo.gulen@ki.se
Besöksadress: Center for Molecular Medicine (CMM) L8, Visionsgatan 18, 17164 Stockholm
Postadress: K2 Medicin, Solna, K2 Imm o lung Nilsson G, 171 77 Stockholm
Forskningsbeskrivning
Mekanismer och biomarkörer för mastcellsaktivering vid anafylaxi, MCAS och mastocytos
Vår forskning utforskar varför mastceller blir dysreglerade och varför mastcellsjukdomar ger så varierande kliniska uttryck. Genom att kombinera kliniska data, proteomik och funktionella mastcellsanalyser identifierar vi biomarkörer och endotyper kopplade till svår anafylaxi och mastcellsaktivering. Målet är att förbättra riskprediktion och möjliggöra mer individanpassad diagnostik och behandling vid MCAS, systemisk mastocytos och andra mastcellsrelaterade tillstånd.
Utvalda publikationer
- Journal article: CURRENT ALLERGY AND ASTHMA REPORTS. 2026;26(1):19Rama TA; Gulen T
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2026;14(1):19-28Akin C; Gulen T; Castells MC; Elberink HO; Valent P
- Journal article: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2025;135(1):33-36Gulen T; Akin C
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(7):1850-1862.e1Beyens M; Sabato V; Ebo DG; Zaghmout T; Gulen T
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(3):753-761Zaghmout T; Maclachlan L; Bedi N; Guelen T
- Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2024;24(2):39-51Gulen T
- Review: DIAGNOSTICS. 2023;13(24):3662Beyens M; Toscano A; Ebo D; Guelen T; Sabato V
- Article: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. 2023;43(4):681-698Gulen T
- Review: DIAGNOSTICS. 2023;13(21):3307Gulen T
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2023;11(10):3010-3020Valent P; Hoermann G; Bonadonna P; Hartmann K; Sperr WR; Broesby-Olsen S; Brockow K; Niedoszytko M; Hermine O; Chantran Y; Butterfield JH; Greiner G; Carter MC; Sabato V; Radia DH; Siebenhaar F; Triggiani M; Guellen T; Alvarez-Twose I; Staudinger T; Traby L; Sotlar K; Reiter A; Horny H-P; Orfao A; Galli SJ; Schwartz LB; Lyons JJ; Gotlib J; Metcalfe DD; Arock M; Akin C
- Article: DIAGNOSTICS. 2023;13(13):2241Jarkvist J; Gulen T
- Article: BLOOD ADVANCES. 2023;7(9):1713-1724Kennedy VE; Perkins C; Reiter A; Jawhar M; Luebke J; Kluin-Nelemans HC; Shomali W; Langford C; Abuel J; Hermine O; Niedoszytko M; Gorska A; Mital A; Bonadonna P; Zanotti R; Tanasi I; Mattsson M; Hagglund H; Triggiani M; Yavuz AS; Panse J; Christen D; Heizmann M; Shoumariyeh K; Mueller S; Elena C; Malcovati L; Fiorelli N; Wortmann F; Vucinic V; Brockow K; Fokoloros C; Papageorgiou SG; Breynaert C; Bullens D; Doubek M; Ilerhaus A; Angelova-Fischer I; Solomianyi O; Varkonyi J; Sabato V; Ruefer A; Schug TD; Hermans MAW; Fortina AB; Caroppo F; Bumbea H; Gulen T; Hartmann K; Elberink HO; Schwaab J; Arock M; Valent P; Sperr WR; Gotlib J
- Article: FRONTIERS IN ALLERGY. 2022;3:1071807Bonadonna P; Olivieri F; Jarkvist J; Nalin F; Zanotti R; Maclachlan L; Gulen T
- Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2022;88(11):4845-4853Kowalik A; de Monestrol I; Sorjonen K; Brockow K; Gulen T
- Article: CANCERS. 2022;14(16):3942Ungerstedt J; Ljung C; Klimkowska M; Gulen T
- Article: ALLERGY. 2022;77(8):2292-2312Barbaud A; Garvey LH; Arcolaci A; Brockow K; Mori F; Mayorga C; Bonadonna P; Atanaskovic-Markovic M; Moral L; Zanoni G; Pagani M; Soria A; Jost M; Caubet J-C; Carmo A; Mona A-A; Alvarez-Perea A; Bavbek S; Benedetta B; Bilo MB; Blanca-Lopez N; Bogas HG; Buonomo A; Calogiuri G; Carli G; Cernadas J; Cortellini G; Celik G; Demir S; Dona I; Dursun AB; Eberlein B; Faria E; Fernandes B; Garcez T; Garcia-Nunez I; Gawlik R; Gelincik A; Gomes E; Gooi JHC; Grosber M; Gulen T; Hacard F; Hoarau C; Janson C; Johnston SL; Joerg L; Ozdemir SK; Klimek L; Kosnik M; Kowalski ML; Kuyucu S; Kvedariene V; Laguna JJ; Lombardo C; Marinho S; Merk H; Meucci E; Morisset M; Munoz-Cano R; Murzilli F; Nakonechna A; Popescu F-D; Porebski G; Radice A; Regateiro FS; Rockmann H; Romano A; Sargur R; Sastre J; Hofmeier KS; Sedlackova L; Sobotkova M; Terreehorst I; Treudler R; Walusiak-Skorupa J; Wedi B; Wohrl S; Zidarn M; Zuberbier T; Agache I; Torres MJ
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(8):1941-1950Valent P; Hartmann K; Bonadonna P; Gulen T; Brockow K; Alvarez-Twose I; Hermine O; Niedoszytko M; Carter MC; Hoermann G; Butterfield JH; Lyons JJ; Sperr WR; Greiner G; Sotlar K; Kluin-Nelemans HC; Schwaab J; Lange M; George TI; Siebenhaar F; Broesby-Olsen S; Jawhar M; Nedoszytko B; Castells M; Orfao A; Gotlib J; Reiter A; Horny H-P; Triggiani M; Arock M; Metcalfe DD; Akin C
- Letter: ALLERGY. 2022;77(6):1909-1911Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarityLyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T; Nilsson G
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(5):1377-1379Lazarinis N; Bossios A; Gulen T
- Article: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. 2022;42(1):45-63Gulen T; Akin C
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2021;9(11):3918-3928Gulen T; Akin C; Bonadonna P; Siebenhaar F; Broesby-Olsen S; Brockow K; Niedoszytko M; Nedoszytko B; Elberink HNGO; Butterfield JH; Sperr WR; Alvarez-Twose I; Horny H-P; Sotlar K; Schwaab J; Jawhar M; Zanotti R; Nilsson G; Lyons JJ; Carter MC; George TI; Hermine O; Gotlib J; Orfao A; Triggiani M; Reiter A; Hartmann K; Castells M; Arock M; Schwartz LB; Metcalfe DD; Valent P
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(3):889-894Gulen T; Teufelberger A; Ekoff M; Westerberg CM; Lyberg K; Dahlen S-E; Dahlen B; Nilsson G
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2021;9(6):2139-2144Bonadonna P; Brockow K; Niedoszytko M; Elberink HO; Akin C; Nedoszytko B; Butterfield JH; Alvarez-Twose I; Sotlar K; Schwaab J; Jawhar M; Castells M; Sperr WR; Hermine O; Gotlib J; Zanotti R; Reiter A; Broesby-Olsen S; Bindslev-Jensen C; Schwartz LB; Horny H-P; Radia D; Triggiani M; Sabato V; Carter MC; Siebenhaar F; Orfao A; Grattan C; Metcalfe DD; Arock M; Gulen T; Hartmann K; Valent P
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2020;8(9):3093-3101Jarkvist J; Brockow K; Gulen T
- Article: ALLERGY. 2020;75(1):169-177Jarkvist J; Salehi C; Akin C; Gulen T
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2017;5(5):1248-1255Gulen T; Ljung C; Nilsson G; Akin C
- Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2017;17(4):295-303Guelen T; Akin C
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(7):909-917Gulen T; Westerberg CM; Lyberg K; Ekoff M; Kolmert J; Bood J; Ohd J; James A; Dahlen S-E; Nilsson G; Dahlen B
- Letter: LEUKEMIA. 2016;30(9):1953-1956Dahlin JS; Ungerstedt JS; Grootens J; Sander B; Guelen T; Haegglund H; Nilsson G
- Review: JOURNAL OF INTERNAL MEDICINE. 2016;279(3):211-228Gulen T; Hagglund H; Dahlen B; Nilsson G
- Doctoral thesis: 2014Gulen T
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(9):1179-1187Gulen T; Hagglund H; Sander B; Dahlen B; Nilsson G
- Editorial: LANCET. 2014;383(9928):1608Gulen T; Hagglund H; Dahlen S-E; Sander B; Dahlen B; Nilsson G
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(1):121-129Gulen T; Hagglund H; Dahlen B; Nilsson G
- Article: TRANSFUSION. 1999;39(6):593-598Steffensen R; Gülen T; Varming K; Jersild C
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Artiklar
- Journal article: LAKARTIDNINGEN. 2025;122:25132[Updated guidelines for anaphylaxis management - simplified structures for enhanced patient safety].Gülen T
- Journal article: LEUKEMIA. 2025;39(3):675-683Ruefer A; Nilius H; Hermine O; Niedoszytko M; Oude Elberink JNG; Bonadonna P; Shoumariyeh K; Gulen T; Hartmann K; Sabato V; Angelova-Fischer I; Baffoe D; Christen D; Belloni Fortina A; Breynaert C; Brockow K; von Bubnoff N; Bumbea H; van Daele P; Doubek M; Dybedal I; Elena C; Fokoloros C; Gorska A; Heizmann M; Jentzsch M; Klein S; Luebke J; Mattsson M; Mulder A; Panse J; Schug TD; Sciume M; Stefan A; Sztormowska M; Varkonyi J; Wortmann F; Yavuz AS; Sperr M; Gotlib J; Reiter A; Triggiani M; Sperr WR; Valent P
- Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2024;12(12):3250-3260.e5Valent P; Hartmann K; Hoermann G; Reiter A; Alvarez-twose I; Brockow K; Bonadonna P; Hermine O; Niedoszytko M; Carter MC; Butterfield JH; Siebenhaar F; Zanotti R; Radia DH; Castells M; Sperr WR; Broesby-Olsen S; Triggiani M; Schwartz LB; George TI; Gulen T; Sotlar K; Gotlib J; Galli SJ; Horny H-P; Metcalfe DD; Orfao A; Arock M; Akin C
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2023;11(6):1706-1717Valent P; Hartmann K; Bonadonna P; Sperr W; Niedoszytko M; Kluin-Nelemans HC; Hermine O; Sotlar K; Hoermann G; Nedoszytko B; Broesby-Olsen S; Zanotti R; Lange M; Doubek M; Brockow K; Alvarez-Twose I; Varkonyi J; Yavuz S; Nilsson G; Radia D; Grattan C; Schwaab J; Gillen T; Elberink HNGO; Haegglund H; Siebenhaar F; Hadzijusufovic E; Sabato V; Mayer J; Reiter A; Orfao A; Horny H-P; Triggiani M; Arock M
- Journal article: JOURNAL OF CYSTIC FIBROSIS. 2022;21:s108Kowalik A; de Monestrol I; Sorjonen K; Gülen T
- Article: ACTA DERMATO-VENEREOLOGICA. 2016;96(5):602-612Broesby-Olsen S; Dybedal I; Gulen T; Kristensen TK; Moller MB; Ackermann L; Saaf M; Karlsson M; Agertoft L; Brixen K; Hermann P; Stylianou E; Mortz CG; Torfing T; Havelund T; Sander B; Bergstrom A; Bendix M; Garvey LH; Weis Bjerrum O; Valent P; Bindslev-Jensen C; Nilsson G; Vestergaard H; Hagglund H
- Article: ACTA DERMATO-VENEREOLOGICA. 2014;94(5):583-584Hagglund H; Sander B; Gulen T; Lindelof B; Nilsson G
- Article: MEDICAL ONCOLOGY. 2014;31(8):123Hagglund H; Sander B; Ahmadi A; Gulen T; Nilsson G
- Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2013;3(1):22Gülen T; Dahlén B; Sander B; Hägglund H; Nilsson G
- Article: MEDICAL ONCOLOGY. 2012;29(5):3540-3546Gulen T; Sander B; Nilsson G; Palmblad J; Sotlar K; Horny H-P; Hagglund H
- Article: LAKARTIDNINGEN. 2007;104(24-25):1881-1882Shemais H; Hot-Bjelak A; Pavlakovic ST; Gülen T
Alla övriga publikationer
- Preprint: RESEARCH SQUARE. 2024Rüfer A; Nilius H; Hermine O; Niedoszytko M; Elberink HO; Bonadonna P; Shoumariyeh K; Gulen T; Hartmann K; Sabato V; Angelova-Fischer I; Baffoe D; Fortina AB; Breynaert C; Brockow K; von Bubnoff N; Bumbea H; Daele PV; Doubek M; Dybedal I; ELENA C; Fokoloros C; Górska A; Heizmann M; Jentzsch M; Luebcke J; Mattsson M; Panse J; Shug T; Sciumè M; Stefan A; Sztormowska M; Várkonyi J; Wortmanns F; Yavuz A; Sperr M; Gotlib J; Reiter A; Triggiani M; Sperr W; Valent P
- Conference publication: ALLERGY. 2023;78:34Jarkvist J; Gulen T
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(8):2015-2024Pyatilova P; Akin C; Alvarez-Twose I; Arock M; Bonadonna P; Brockow K; Butterfield JH; Broesby-Olsen S; Carter MC; Castells M; George TI; Gotlib J; Greiner G; Gulen T; Hartmann K; Hermine O; Horny H-P; Jawhar M; Lange M; Lyons JJ; Maurer M; Metcalfe DD; Nedoszytko B; Niedoszytko M; Orfao A; Reiter A; Schwaab J; Sotlar K; Sperr WR; Triggiani M; Valent P; Siebenhaar F
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2022;10(4):1128Gulen T; Akin C; Metcalfe DD; Valent P
- Preprint: AUTHOREA PREPRINTS. 2021Mast cells derived from systemic mastocytosis exhibit an increased responsiveness to hyperosmolarityNilsson G; Lyberg K; Ekoff M; Westerberg CM; Engblom C; Dahlen B; Gulen T
- Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2021;21(2):11Gulen T; Akin C
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1454Romantowski J; Gorska A; Niedoszytko M; Gulen T; Gruchala-Niedoszytko M; Nedoszytko B; Lange M; Brockow K; Arock M; Akin C; Valent P
- Conference publication: PEDIATRIC PULMONOLOGY. 2020;55:S251Kowalik A; Gulen T; de Monestrol I
- Conference publication: ALLERGY. 2020;75:195-196Jarkvist J; Brockow K; Gulen T
- Book chapter: MASTOCYTOSIS. 2020;p. 141-155Gülen T; Oude Elberink JNG; Brockow K
- Conference publication: ALLERGY. 2019;74:670Jarkvist J; Bonadonna P; Gulen T
- Conference publication: ALLERGY. 2018;73:69Salehi C; Jarkvist J; Nilsson G; Akin C; Gulen T
- Editorial: ACTA DERMATO-VENEREOLOGICA. 2018;98(1):149-150Guelen T; Akin C
- Conference publication: ALLERGY. 2017;72:445Gulen T; Lyberg K; Westerberg MC; Ekoff M; Alexeyenko A; Dahlen B; Nilsson G
- Review: LAKARTIDNINGEN. 2016;113:D7CIGülen T; Björkander J
- Conference publication: ALLERGY. 2016;71:77Ljung C; Nilsson G; Akin C; Gulen T
- Review: LAKARTIDNINGEN. 2016;113:DTEDGülen T; Wickman M
- Conference publication: ALLERGY. 2015;70:72Gulen T; Moller-Westerberg C; Lyberg K; Kolmert J; Bood J; Dahlen S-E; Dahlen B; Nilsson G
- Editorial: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(9):1099Zhang X-Y; Ziyab A; Guelen T
- Conference publication: ALLERGY. 2014;69:13Gulen T; Westerberg MC; Kolmert J; Larsson J; Dahlen S-E; Dahlen B; Nilsson G
- Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2014;44Bood J; Kolmert J; Gulen T; Delin I; Wheelock C; Dahlen B; Nilsson G; Dahlen S-E
- Conference publication: ALLERGY. 2013;68:499-500Gulen T; Hagglund H; Dahlen B; Nilsson G
- Conference publication: ALLERGY. 2012;67:564Gulen T; Dahlen B; Sander B; Hagglund H; Nilsson G
- Review: LAKARTIDNINGEN. 2012;109(9-10):474-477Gülen T; Gottberg L; Dahlén B; Nilsson G; Hägglund H
- Conference publication: ALLERGY. 2011;66:114Gulen T; Larsson J; Balgoma D; Delin I; Wheelock C; Dahlen B; Hagglund H; Nilsson G; Dahlen S
- Conference publication: ALLERGY. 2011;66:152Gulen T; Nilsson G; Dahlen S; Dahlen B; Saaf M; Emtestam L; Bendix M; Billgert L; Sander B; Hagglund H
- Review: LAKARTIDNINGEN. 2008;105(46):3341-3347Hägglund H; Gülen T; Sääf M; Sander B; Nilsson G
- Review: LAKARTIDNINGEN. 2007;104(26-27):1982-1986Gülen T; Gottberg L
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Forskningsbidrag
- Recurrent Anaphylaxis: Can We Predict Who Is at Risk?Svenska föreningen för Allergologi1 January 2025
- Swedish Heart-Lung Foundation1 January 2022 - 31 December 2024
Anställningar
- Anknuten till Forskning, Medicin, Huddinge, Karolinska Institutet, 2024-2027
- Anknuten till Forskning, Medicin, Solna, Karolinska Institutet, 2023-2026
Examina och utbildning
- Docent, Allergologi, Karolinska Institutet, 2023
- Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2014