Taher Darreh-Shori

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: BIOORGANIC CHEMISTRY. 2024;147:107373
Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer's disease
Das B; Baidya ATK; Chakrabarti S; Chouhan D; Thakur B; Darreh-Shori T; Chen G; Tiwari V; Kumar R
Article: BMC NEUROLOGY. 2024;24(1):116
Onset of Alzheimer disease in apolipoprotein ε4 carriers is earlier in butyrylcholinesterase K variant carriers
Lane RM; Darreh-Shori T; Junge C; Li D; Yang Q; Edwards AL; Graham DL; Moore K; Mummery CJ
Article: BIOLOGY OF REPRODUCTION. 2024;110(1):63-77
Presence of key cholinergic enzymes in human spermatozoa and seminal fluid†.
Thakur B; Hasooni LP; Gera R; Mitra S; Björndahl L; Darreh-Shori T
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2023;15(1):137
Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App^NL-G-F knock-in Alzheimer mice
Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg LU; Darreh-Shori T; Behbahani H; Nilsson P; Eriksdotter M
Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S1)
Hippocampal BDNF encapsulated cell bio‐delivery improves spontaneous behavioral alternations in the Y‐maze test in AppNL‐G‐F mice.
Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg L; Behbahani H; Darreh‐Shori T; Nilsson P; Eriksdotter M
Article: JOURNAL OF MOLECULAR STRUCTURE. 2023;1276:134782
Synthesis, single crystal X-ray, DFT, spectroscopic, molecular docking studies and in vitro biological evaluation of compound N-benzyl-4-(4-chlorophenyl)-2-oxobutanamide
Das B; Baidya ATK; Devi B; Rom T; Paul AK; Thakur B; Darreh-Shori T; Kumar R
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(4):749-765
Mechanistic Insight into the Inhibition of Choline Acetyltransferase by Proton Pump Inhibitors
Baidya ATK; Das B; Devi B; Langstroem B; agren H; Darreh-Shori T; Kumar R
Article: KIDNEY INTERNATIONAL. 2023;103(1):166-176
Association between cholinesterase inhibitors and kidney function decline in patients with Alzheimer's dementia
Xu H; Garcia-Ptacek S; Bruchfeld A; Fu EL; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
Journal article: NEUROMODULATION. 2022;25(7):s33-s34
O003 / #714 COGNITIVE RESTORATION IN ALZHEIMER’S PATIENTS BY LOCAL INTRACEREBRAL CELL-MEDIATED NERVE GROWTH FACTOR DELIVERY: CLINICAL EFFICACY AND FURTHER METHOD OPTIMIZATION ORAL POSTER PRESENTATIONS FIVE BEST ABSTRACTS
Linderoth B; Mitra S; Almqvist P; Lind G; Eyjolfsdottir H; Behbahani H; Darreh-Shori T; Ruchi G; Westman E; Seiger Å; Wahlberg L; Eriksdotter M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(11):6073
Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling
Baidya ATK; Kumar A; Kumar R; Darreh-Shori T
Journal article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2022;37(Supplement_3):gfac115.001
FC081: Cholinesterase Inhibitors and Kidney Function Decline in Patients with Alzheimer's Dementia
Xu H; Garcia-Ptacek S; Bruchfeld A; Fu E; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:876019
Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects
Teitsdottir UD; Darreh-Shori T; Lund SH; Jonsdottir MK; Snaedal J; Petersen PH
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:756687
Fast Alpha Activity in EEG of Patients With Alzheimer's Disease Is Paralleled by Changes in Cognition and Cholinergic Markers During Encapsulated Cell Biodelivery of Nerve Growth Factor
Eyjolfsdottir H; Koenig T; Karami A; Almqvist P; Lind G; Linderoth B; Wahlberg L; Seiger A; Darreh-Shori T; Eriksdotter M; Jelic V
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:714186
Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers
Mitra S; Turconi G; Darreh-Shori T; Matlik K; Aquilino M; Eriksdotter M; Andressoo J-O
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:704583
CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment
Karami A; Darreh-Shori T; Schultzberg M; Eriksdotter M
Article: BIOCHEMICAL PHARMACOLOGY. 2020;182:114212
Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index
Kumar A; Kumar R; Flanagan J; Langstrom B; Bjorndahl L; Darreh-Shori T
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2020;12(1):92
Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions
Teitsdottir UD; Jonsdottir MK; Lund SH; Darreh-Shori T; Snaedal J; Petersen PH
Article: ALZHEIMER'S AND DEMENTIA. 2020;16(7):1031-1042
Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia
Kumar R; Kumar A; Nordberg A; Langstrom B; Darreh-Shori T
Article: GENETICS AND MOLECULAR BIOLOGY. 2020;43(4):e20190404
Influence of a genetic variant of CHAT gene over the profile of plasma soluble ChAT in Alzheimer disease
Rocha-Dias PF; Simao-Silva DP; Lopes da Silva SS; Piovezan MR; Souza RKM; Darreh-Shori T; Furtado-Alle L; Rodrigues Souza RL
Article: FRONTIERS IN GENETICS. 2020;11:1022
Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL
Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
Journal article: INDIAN DRUGS. 2019;56(10):22-25
PYRAZOLINE CONTAINING MOLECULES AS MULTIFUNCTIONAL AGENTS IN ALZHEIMER’S DISEASE
Khambete M; Murumkar P; Kumar A; Darreh-Shori T; De S; Yadav MR; Degani MS
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2019;11(1):80
Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas
Sinclair LI; Kumar A; Darreh-Shori T; Love S
Article: GUT. 2019;68(7):1210-1223
Changes in neuromuscular structure and functions of human colon during ageing are region-dependent
Broad J; Kung VWS; Palmer A; Elahi S; Karami A; Darreh-Shori T; Ahmed S; Thaha MA; Carroll R; Chin-Aleong J; Martin JE; Saffrey MJ; Knowles CH; Sanger GJ
Article: MOLECULAR NEUROBIOLOGY. 2019;56(7):4601-4619
Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain
Darreh-Shori T; Rezaeianyazdi S; Lana E; Mitra S; Gellerbring A; Karami A; Bogdanovic N; Lithner CU; Winblad B; Behbahani H
Journal article: ALZHEIMER'S AND DEMENTIA. 2019;15(7S_Part_18):p971
P3‐108: CHAT POTENTIATING LIGANDS (CPLS): A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Kumar A; Murumkar P; Kumar R; Yadav MR; Darreh-Shori T
Journal article: ALZHEIMER'S AND DEMENTIA. 2019;15(7S_Part_5):p269
P1‐090: DISCOVERY OF NOVEL SMALL MOLECULES FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Murumkar PR; Yadav MR; Darreh-Shori T; Kumar A; Kumar R
Journal article: ALZHEIMER'S AND DEMENTIA. 2019;15(7S_Part_31):p1630
O5‐06‐06: LIGANDS OF THE CORE ACETYLCHOLINE BIOSYNTHESIZING ENZYME, CHOLINE ACETYLTRANSFERASE, AS NOVEL AND POTENTIAL THERAPEUTIC AGENTS AND IN VIVO PET TRACERS FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE
Darreh-Shori T; Kumar R; Kumar A; Murumkar P; Nag S; Jia Z; Arakawa R; Leuzy A; Lemoine L; Nordberg A; Yadav MR; Halldin C; Långström B
Journal article: ALZHEIMER'S AND DEMENTIA. 2019;15(7S_Part_12):p614
P2‐109: CSF CHOLINERGIC INDEX, A NEW BIOMEASURE OF TREATMENT EFFECT IN PATIENTS WITH ALZHEIMER'S DISEASE
Karami A; Eriksdotter M; Kadir A; Almkvist O; Nordberg AK; Darreh-Shori T
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:176
Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer's Disease Status and Risk Genotype
Lana E; Gellerbring A; Jung S; Nordberg A; Lithner CU; Darreh-Shori T
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:239
CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer's Disease
Karami A; Eriksdotter M; Kadir A; Almkvist O; Nordberg A; Darreh-Shori T
Journal article: ALZHEIMER'S AND DEMENTIA. 2018;14(7S_Part_7):p371
P1‐241: SOLUBLE AMYLOID‐BETA ACTIVATES CHOLINE ACETYLTRANSFERASE
Kumar A; Lana E; Kumar R; Lithner CU; Darreh-Shori T
Journal article: ALZHEIMER'S AND DEMENTIA. 2018;14(7S_Part_4):p261
P1‐001: CSF CHOLINE ACETYLTRANSFERASE SHOWS DIFFERENTIAL LEVELS AMONG HEALTHY CONTROLS AND PATIENTS WITH AD AND MCI
Karami A; Darreh-Shori T; Zetterberg H; Blennow K; Eriksdotter M
Journal article: ALZHEIMER'S AND DEMENTIA. 2018;14(7S_Part_21):p1147-p1148
P3‐207: ARE VISUAL HALLUCINATIONS IN ALZHEIMER'S DISEASE A RESULT OF HYPOPERFUSION OF VISUAL PROCESSING AREAS IN THE OCCIPITAL CORTEX?
Sinclair LI; Darreh-Shori T; Mandagere V; Love S
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2018;11:327
Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase
Kumar A; Lana E; Kumar R; Lithner CU; Darreh-Shori T
Article: ACS CHEMICAL NEUROSCIENCE. 2017;8(12):2618-2625
DMSO: A Mixed-Competitive Inhibitor of Human Acetylcholinesterase
Kumar A; Darreh-Shori T
Article: SCIENTIFIC REPORTS. 2017;7(1):16287
Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening
Kumar R; Kumar A; Langstrom B; Darreh-Shori T
Journal article: ALZHEIMER'S AND DEMENTIA. 2017;13(7S_Part_14):p696
[P2–224]: NOVEL LIGANDS OF CHOLINE ACETYLTRANSFERASE AND CHOLINESTERASES: DRUG‐REPURPOSING STRATEGIES AND IDENTIFICATION OF POTENTIAL PET TRACERS AS IN VIVO BIOMARKERS
Kumar A; Kumar R; Darreh‐Shori T
Article: SCIENTIFIC REPORTS. 2016;6:31247
Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization
Kumar R; Langstrom B; Darreh-Shori T
Article: ALZHEIMER'S RESEARCH AND THERAPY. 2016;8(1):30
Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device
Eyjolfsdottir H; Eriksdotter M; Linderoth B; Lind G; Juliusson B; Kusk P; Almkvist O; Andreasen N; Blennow K; Ferreira D; Westman E; Nennesmo I; Karami A; Darreh-Shori T; Kadir A; Nordberg A; Sundstrom E; Wahlund L-O; Wall A; Wiberg M; Winblad B; Seiger A; Wahlberg L; Almqvist P
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2016;50(2):567-576
Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ε4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease
Vijayaraghavan S; Darreh-Shori T; Rongve A; Berge G; Sando SB; White LR; Auestad BH; Witoelar A; Andreassen OA; Ulstein ID; Aarsland D
Article: BRAIN. 2016;139(Pt 1):174-192
Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs
Kumar R; Nordberg A; Darreh-Shori T
Article: ALZHEIMER'S AND DEMENTIA. 2015;11(11):1316-1328
Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease
Karami A; Eyjolfsdottir H; Vijayaraghavan S; Lind G; Almqvist P; Kadir A; Linderoth B; Andreasen N; Blennow K; Wall A; Westman E; Ferreira D; Wiberg MK; Wahlund L-O; Seiger A; Nordberg A; Wahlberg L; Darreh-Taher T; Eriksdotter M
Article: PLOS ONE. 2015;10(4):e0122048
Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis
Aeinehband S; Lindblom RPF; Al Nimer F; Vijayaraghavan S; Sandholm K; Khademi M; Olsson T; Nilsson B; Ekdahl KN; Darreh-Shori T; Piehl F
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2014;43(3):1059-1072
Brain Changes in Alzheimer's Disease Patients with Implanted Encapsulated Cells Releasing Nerve Growth Factor
Ferreira D; Westman E; Eyjolfsdottir H; Almqvist P; Lind G; Linderoth B; Seiger A; Blennow K; Karami A; Darreh-Shori T; Wiberg M; Simmons A; Wahlund L-O; Wahlberg L; Eriksdotter M
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2014;18(9):1874-1888
Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation
Malmsten L; Vijayaraghavan S; Hovatta O; Marutle A; Darreh-Shori T
Article: ALZHEIMER'S AND DEMENTIA. 2014;10(5):530-540.e1
High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia
Vijayaraghavan S; Maetzler W; Reimold M; Lithner CU; Liepelt-Scarfone I; Berg D; Darreh-Shori T
Journal article: ALZHEIMER'S AND DEMENTIA. 2014;10(4S_Part_17):p620
P2‐387: NGF CELL THERAPY IN AD PATIENTS: EFFECTS ON CSF CHOLINERGIC BIOMARKERS
Karami A; Eyjolfsdottir H; Vijayaraghavan S; Lind G; Per A; Kadir A; Linderoth B; Andreasen N; Nordberg A; Wall A; Wahlund L; Seiger Å; Wahlberg L; Darreh‐Shori T; Eriksdotter M
Journal article: ALZHEIMER'S AND DEMENTIA. 2014;10(4S_Part_3):p215
O3‐04‐02: EPIGENETIC MODIFICATIONS IN ALZHEIMER'S DISEASE: EFFECTS OF BETA‐AMYLOID EXPOSURE
Lana E; Chen X; Jung S; Wiehager B; Ankarcrona M; Darreh‐Shori T; Lithner CU
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1138-1153
Unbiased Expression Mapping Identifies a Link between the Complement and Cholinergic Systems in the Rat Central Nervous System
Lindblom RPF; Stroem M; Heinig M; Al Nimer F; Aeinehband S; Berg A; Dominguez CA; Vijayaraghavan S; Zhang X-M; Harnesk K; Zelano J; Huebner N; Cullheim S; Darreh-Shori T; Diez M; Piehl F
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2014;39(2):423-440
Pharmacodynamics of Cholinesterase Inhibitors Suggests Add-on Therapy with a Low-Dose Carbamylating Inhibitor in Patients on Long-Term Treatment with Rapidly Reversible Inhibitors
Darreh-Shori T; Hosseini SM; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2013;34(11):2465-2481
Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease
Darreh-Shori T; Vijayaraghavan S; Aeinehband S; Piehl F; Lindblom RPF; Nilsson B; Ekdahl KN; Langstrom B; Almkvist O; Nordberg A
Journal article: ALZHEIMER'S AND DEMENTIA. 2013;9(4S_Part_13):p547-p548
O3–13–01: Low‐grade inflammatory processes stimulate regenerative mechanisms in Alzheimer's disease
Malmsten L; Lilja A; Rojdner J; Voytenko L; Vijayaraghavana S; Hovatta O; Darreh‐Shori T; Nordberg A; Marutle A
Article: INTERNATIONAL JOURNAL OF ALZHEIMER'S DISEASE. 2013;2013:473181-2
Biomarkers in Alzheimer's disease and lewy body disorders with dementia.
Leyhe T; Darreh-Shori T; Laske C; Mielke MM; Maetzler W
Article: THE PRIMARY CARE COMPANION FOR CNS DISORDERS. 2013;15(2):PCC.12r01412
A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease.
Nordberg A; Ballard C; Bullock R; Darreh-Shori T; Somogyi M
Article: PLOS ONE. 2013;8(6):e65936
Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway
Vijayaraghavan S; Karami A; Aeinehband S; Behbahani H; Grandien A; Nilsson B; Ekdahl KN; Lindblom RPF; Piehl F; Darreh-Shori T
Article: JOURNAL OF ALZHEIMER'S DISEASE. 2012;28(2):443-458
Apolipoprotein ε4 Modulates Phenotype of Butyrylcholinesterase in CSF of Patients with Alzheimer's Disease
Darreh-Shori T; Siawesh M; Mousavi M; Andreasen N; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2011;32(12):2320.e15-2320.e32
Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo
Darreh-Shori T; Forsberg A; Modiri N; Andreasen N; Blennow K; Kamil C; Ahmed H; Almkvist O; Langstrom B; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2011;32(7):1236-1248
The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
Darreh-Shori T; Modiri N; Blennow K; Baza S; Kamil C; Ahmed H; Andreasen N; Nordberg A
Journal article: ALZHEIMER'S AND DEMENTIA. 2011;7(4S_Part_12):s407
P2‐303: Impact of Butyrylcholinesterase K genotype on glial and proinflammatory markers in CSF of patients with Alzheimer's disease.
Darreh‐Shori T; Bälter M; Siawesh M; Nordberg A
Journal article: ALZHEIMER'S AND DEMENTIA. 2011;7(4S_Part_12):s416
P2‐332: The influence of beta‐amyloid 1‐42 on inflammatory processes and regenerative mechanisms in Alzheimer's disease
Wicklund L; Marutle A; Hertwig L; Hovatta O; Nordberg A; Darreh‐Shori T
Article: BRAIN. 2011;134(Pt 1):301-317
Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease
Kadir A; Marutle A; Gonzalez D; Scholl M; Almkvist O; Mousavi M; Mustafiz T; Darreh-Shori T; Nennesmo I; Nordberg A
Article: CURRENT ALZHEIMER RESEARCH. 2010;7(1):67-73
Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimer's Disease: A Review of Recent Clinical Studies
Darreh-Shori T; Soininen H
Journal article: CLINICAL MEDICINE INSIGHTS: THERAPEUTICS. 2010;2:cmt.s5410
Donepezil: A Review of Pharmacological Characteristics and Role in the Management of Alzheimer Disease
Jelic V; Darreh-Shori T
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2010;29(3):204-212
Pittsburgh Compound-B and Alzheimer's Disease Biomarkers in CSF, Plasma and Urine: An Exploratory Study
Gunnarsson MD; Lindau M; Wall A; Blennow K; Darreh-Shori T; Basu S; Nordberg A; Larsson A; Lannfelt L; Basun H; Kilander L
Journal article: CURRENT ALZHEIMER RESEARCH. 2009;999(999):1-6
Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimer's disease: A Review of Recent Clinical Studies
Darreh-Shori T
Article: PHARMACOGENETICS AND GENOMICS. 2009;19(8):635-646
Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment
Ferris S; Nordberg A; Soininen H; Darreh-Shori T; Lane R
Journal article: ALZHEIMER'S AND DEMENTIA. 2009;5(4S_Part_11):p332
P2‐246: Effects of rivastigmine on brain white matter volume in Mild Cognitive Impairment (MCI)
Ferris S; Darreh‐Shori T; Lane R
Journal article: ALZHEIMER'S AND DEMENTIA. 2009;5(4S_Part_10):p305
P2‐151: ApoE and amyloid beta deflate the cholinergic neurotransmission by boosting the activity and stability of cholinesterases in the brain
Darreh‐Shori T; Modiri N; Nordberg A
Journal article: ALZHEIMER'S AND DEMENTIA. 2009;5(4S_Part_7):p225
P1‐163: Apolipoprotein E and Butyrylcholinesterase synergistically promote Ab peptides oligomerization
Darreh‐Shori T; Modiri N; Nordberg A
Article: CURRENT ALZHEIMER RESEARCH. 2009;6(3):290-292
Safety of Lumbar Puncture Procedures in Patients with Alzheimer's Disease
Peskind E; Nordberg A; Darreh-Shori T; Soininen H
Article: CURRENT ALZHEIMER RESEARCH. 2009;6(1):4-14
Different Cholinesterase Inhibitor Effects on CSF Cholinesterases in Alzheimer Patients
Nordberg A; Darreh-Shori T; Peskind E; Soininen H; Mousavi M; Eagle G; Lane R
Article: NEUROBIOLOGY OF AGING. 2008;29(8):1204-1217
PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD
Kadir A; Darreh-Shori T; Almkvist O; Wall A; Grut M; Strandberg B; Ringheim A; Eriksson B; Blomquist G; Langstrom B; Nordberg A
Journal article: ALZHEIMER'S AND DEMENTIA. 2008;4(4S_Part_18):t608
P3‐293: Interaction between amyloid‐beta peptides with butyrylcholinesterase and ApoE proteins: Mechanism of amyloid fibrils deposition in the brain of patients with Alzheimer's disease
Darreh-Shori T; Forsberg A; Andreasen N; Blennow K; Wall A; Kamil C; Långström B; Nordberg A
Article: PHARMACOGENETICS AND GENOMICS. 2008;18(4):289-298
Synergistic effect of apolipoprotein E ε4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease
Lane R; Feldman HH; Meyer J; He Y; Ferris SH; Nordberg A; Darreh-Shori T; Soininen H; Pirttila T; Farlow MR; Sfikas N; Ballard C; Greig NH
Article: NEUROBIOLOGY OF AGING. 2008;29(2):168-184
Inhibition of acetylcholinesterase in CSF versus brain assessed by ¹¹C-PMP PET in AD patients treated with galantamine
Darreh-Shori T; Kadir A; Almkvist O; Grut M; Wall A; Blomquist G; Eriksson B; Langstrom B; Nordberg A
Article: PSYCHOPHARMACOLOGY. 2007;191(4):1005-1014
Changes in brain ¹¹C-nicotine binding sites in patients with mild Alzheimer's disease following rivastigmine treatment as assessed by PET
Kadir A; Darreh-Shori T; Almkvist O; Wall A; Langstrom B; Nordberg A
Article: JOURNAL OF NEURAL TRANSMISSION. 2006;113(11):1791-1801
Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment
Darreh-Shori T; Meurling L; Pettersson T; Hugosson K; Hellstrom-Lindahl E; Andreasen N; Minthon L; Nordberg A
Article: NEUROBIOLOGY OF DISEASE. 2006;24(2):326-333
Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE ε4 allele, in relation to cognitive function and cerebral glucose metabolism
Darreh-Shori T; Brimijoin S; Kadir A; Almkvist O; Nordberg A
Journal article: ALZHEIMER'S AND DEMENTIA. 2006;2(3S_Part_9):s273
P2–136: Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE ϵ4 allele, in relation to cognitive function and cerebral glucose metabolism
Darreh-Shori T; Brimijoin S; Kadir A; Almkvist O; Nordberg A
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2004;11(4):253-261
Preserved cognitive function after 12 months of treatment with rivastigmine in mild Alzheimer's disease in comparison with untreated AD and MCI patients
Almkvist O; Darreh-Shori T; Stefanova E; Spiegel R; Nordberg A
Article: JOURNAL OF NEUROCHEMISTRY. 2004;88(5):1102-1113
Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients
Darreh-Shori T; Hellström-Lindahl E; Flores-Flores C; Guan ZZ; Soreq H; Nordberg A
Article: NEUROLOGY. 2002;59(4):563-572
Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
Darreh-Shori T; Almkvist O; Guan ZZ; Garlind A; Strandberg B; Svensson AL; Soreq H; Hellström-Lindahl E; Nordberg A
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;54(1-2):180-189
Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different FLIP isoforms
Djerbi M; Darreh-Shori T; Zhivotovsky B; Grandien A
Journal article: NEUROBIOLOGY OF AGING. 2000;21:243
Long term rivastigmine treatment produces persistent inhibition of acetyl- and butyrylcholinesterase activity in CSF of Alzheimer's patients
Darreh-Shori T; Svensson A-L; Nordberg A
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Preprint: RESEARCH SQUARE. 2020
Association of glial and neuronal degeneration markers with Alzheimer‘s disease cerebrospinal fluid profile and cognitive functions
Teitsdottir UD; Jonsdottir MK; Lund SH; Darreh-Shori T; Snaedal J; Petersen PH
Preprint: RESEARCH SQUARE. 2020
Association of glial and neuronal degeneration markers with Alzheimer‘s disease cerebrospinal fluid profile and cognitive functions
Teitsdottir UD; Jonsdottir MK; Lund SH; Darreh-Shori T; Snaedal J; Petersen PH
Conference publication: JOURNAL OF NEUROCHEMISTRY. 2017;142:214
Amyloid beta peptides act as allosteric modulators of cholinesterases
Kumar R; Darreh-Shori T
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2017;253
Hologram QSAR and structure-based design of novel small-molecule inhibitors of choline acetyltransferase
Kumar R; Darreh-Shori T
Conference publication: NEUROBIOLOGY OF AGING. 2016;39:S29
NEW LIGANDS OF CHOLINE ACETYLTRANSFERASE AS THERAPEUTICS AND IN VIVO FUNCTIONAL BIOMARKERS IN ALZHEIMER'S DISEASE
Darreh-Shori T
Review: JOURNAL OF ALZHEIMER'S DISEASE. 2015;44(4):1039-1062
Understanding the Beneficial and Detrimental Effects of Donepezil and Rivastigmine to Improve their Therapeutic Value
Lane RM; Darreh-Shori T
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2015;249
Molecular modeling studies of choline acetyltransferase inhibitors as potential PET probes
Kumar R; Darreh-Shori T
Meeting abstract: NEUROBIOLOGY OF AGING. 2012;33:S6
THE RELATIONSHIP BETWEEN CHOLINESTERASES AND AD PATHOLOGY
Darreh-Shori T
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19:91
Cell therapy with NGF in patients with Alzheimer's disease: changes in CSF cholinergic markers
Karami A; Eyjolfsdottir H; Vijayaraghavan S; Kadir A; Linderoth B; Lind G; Andreasen N; Wall A; Seiger A; Almqvist P; Wahlberg L; Nordberg A; Darreh-Shori T; Eriksdotter M
Review: EXPERT OPINION ON DRUG SAFETY. 2010;9(1):167-176
Safety and tolerability of transdermal and oral rivastigmine in Alzheimer's disease and Parkinson's disease dementia
Darreh-Shori T; Jelic V
Thesis / dissertation: 2006
Molecular changes of acetylcholinesterase and butyrylcholinesterase in Alzheimer patients during the natural couse of the disease and treatment with cholinesterase inhibitors : insight into neurochemical mechanisms affecting the progression of the disease
Darreh-Shori, Taher
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S375
Long-term changes in the protein levels of different acetylcholinesterase (ACHE) isoforms in cerebrospinal fluid (CSF) of rivastigmine and tacrine treated AD patients
Darreh-Shori T; Nordberg A; Hellström-Lindahl E; Flores-Flores C; Soreq H

Forskningsbidrag

Investigating the potential of combination therapies targeting the cholinergic system in Alzheimer´s disease
Swedish Research Council
1 January 2021 - 31 December 2023
Gene Knock Up via 3’UTR targeting to treat Alzheimer’s disease
Swedish Research Council
1 January 2020 - 31 December 2022
Targeting the core cholinergic cells for development of biomarkers and therapeutic strategies in Alzheimer´s disease
Swedish Research Council
1 January 2017 - 31 December 2020
The revival of the cholinergic system in Alzheimer´s disease - Cognitive impairment, cognitive restoration and early diagnosis in Alzheimer´s disease
Swedish Research Council
1 January 2017 - 31 December 2020
Novel Lead ChAT-PET tracer as early diagnostic and theragonistic biomarker
Alzheimer's Association
1 January 2016

Anställningar

Senior Forskare, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Molekylär farmakologi, Karolinska Institutet, 2014
MEDICINE DOKTORSEXAMEN, Institutionen för neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2006

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